Systemic mycosis (1) Aspergillosis Mrs. Dalia Kamal Eldien Msc in Microbiology Lecture No-10-
Primary systemic mycosis
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Transcript of Primary systemic mycosis
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PRIMARY SYSTEMIC MYCOSIS
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PRIMARY SYSTEMIC MYCOSIS Blastomycosis
Blastomyces dermatitidis
Coccidioidomycosis Coccidioides immitis
Paracoccidioidomycosis Paracoccidioidoes brasiliensis
Histoplasmosis Histoplasma capsulatum
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SYSTEMIC MYCOSIS CAUSED BY DIMORPHIC ONYGENALESRelated dimorphic fungiMost of them restricted to
particular endemic areasPrimary pathogens Inhalation from dustIn most cases exposure:
No clinical diseasePositive skin test (14 days)
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SYSTEMIC MYCOSIS CAUSED BY DIMORPHIC ONYGENALES Acute reactions:
Asymptomatic or Symptomatic, which may heal or develop into
chronic lung disease Endogenous reactivation Occasionally disseminate to:
Skin CNS Visceral organs
Drug of choice Amphotericin B
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SUMMARYAgent infection Dissemination Drug of
choiceBlastomyces dermatitidis
Blastomycosis Skin and bone Later nervous system and visceral organs
Amphotericin B itraconazole
Coccidioides immitis
Coccidioidomycosis Skin, bones, joints, subcutaneous tissues, and visceral organs
Amphotericin B
Paracoccidioidoes brasiliensis
Paracoccidioidomycosis
Oro-nasal mucosa latter spleen, liver, intestine and skin
Amphotericin B + sulfas or azoles
Histoplasma capsulatum
Histoplasmosis Acute pneumonia (cave disease)
Chronic pneumonia (smoker)
Disseminated (immunocompromised)
Primary cutaneous (lab accidents)
Amphotericin B
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Blastomycosis
Skin lesions resulting from the dissemination of the fungus from the lungs
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Coccidioidomycosis
Extension of pulmonary coccidioidomycosis
showing a large superficial ulcerated lesion
Chronic cutaneous granulomatous lesions of the
face, neck and chin
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Paracoccidioidomycosis
Ulcerated lesion on the pharyngeal
mucosa
Extensive destruction of facial features
Ulcerated lesion on the nasal mucosa
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LABORATORY DIAGNOSIS1. Clinical material:
Skin scrapings Respiratory specimens CSF Pleural fluid and blood Bone marrow Urine Tissue biopsies from various visceral organs
2. Direct Microscopy: 10% KOH, PAS, Silver or Gram stain
3. Culture: SDA + BHIA at 37°C
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Tissue sections showing large,
broad-base, unipolar budding
yeast-like cells
Blastomycosis
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Broad based budding and
thickened cell walls and globose
shape are characteristic of the
yeast form of Blastomyces
dermatitidis
One-celled conidia formed
on short conidiophores.
Blastomyces dermatitidis
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Tissue section showing typical endosporulating spherules of
C. immitis
Coccidioidomycosis
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Coccidioides immitis showing typical single-celled, hyaline, rectangular to barrel-shaped, alternate arthroconidia
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Paracoccidioidoes brasiliensis
Multiple, narrow base, budding yeast cells "steering wheels" of P. brasiliensis
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Paracoccidioidoes brasiliensis
Multiple, narrow base, budding yeast cells "steering wheels" of P. brasiliensis
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PAS stain showing Histoplasma capsulatum yeast cells in liver specimen
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Rough-walled macroconidia
Macroconidia and microconidia
Histoplasma capsulatum
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