PREFACE
1
PREFACE The major part of the present work was carried out in the Department of Oncology ONA at the Finsen Institute, Copenhagen, where I first worked as a House Officer, and afterwards as a Research Fellow from 1986-88 supported by the Danish Cancer Society.The investigation is based on patients with Medullary Carcinoma of the Breast registered in the Danish Breast Cancer Co- operative Group (DBCG), wherefrom the clinical data were kindly delivered.The pathological spe- cimens were kindly retrieved and delivered from pathological departments all over Denmark. My interest in this particular kind of breast cancer was primarily encouraged by my former Chief Consultant Henning T. Mouridsen, Dr.Sci., M.D., to whom I am greatly indebted for his never failing support throughout the investigation and the following years of paper work. I wish especially to thank my colleagues in pathology, Consultant Susanne Holck, DrSci., M.D. and Professor Torben Schiardt, DrSci., M.D., for their reviewing and reclassification of the histopathologicalspecimens, for our inspiring and fruithl discussions, and for their support in general. Abbrevations: MC TMC = Typical Medullary Carcinoma AMC = Atypical Medullary Carcinoma NMC = Non-Medullary Carcinoma IDC = Infiltrating Ductal Carcinoma IDC-NOS = Infiltrating Ductal Carcinoma FCM = Flow Cytometry DI = DNAIndex SF CD = Cathepsin-D K19 = Keratin19 ICAM-1 = Intercellular adhesion molecule-1 LFA-1 = Integrin Lymphocyte-function- associated Antigen DBCG Group = Medullary Carcinoma of the breast Not Otherwise Specified = Synthetic phase of cell cycle = Danish Breast Cancer Cooperative I am gratehl to Karin Zedeler from the DBCG for her expert help concerning the statistics and for good fellowship. I hrther should like to ex- press my thanks to the DBCG Secretariat for their always kind and willing cooperation. I thank Jnrrgen Larsen, MSc, and Ib J. Christen- sen, MSc, of the Finsen Laboratory for their great work concerning the DNA profile. In addition, I want to thank those of my collea- gues, whose discussions and support have been va- luable to me at different times during my work, especially Dr Carsten Rose and Dr Claw Kamby, my “room-mate” from the office of Research Fel- lows at the Finsen Institute. Last, but not least, I want to thank my scientific secretary during sev- eral years, Disa la Cour, for her skilled and always competent work, and for her friendship. I also thank Pia Hirsch, secretary to H.T. Mouridsen, for her kind and ready help whenever needed. The study was supported financially by grants from the “Danish Cancer Society”, “Tnrmrerme- ster Otto V. Madsen og hustru Irma Madsen’s Fond”, and “Mogens Ambt Balslevs Mindefond”. The publication of the present review was sup- ported by the Danish Medical Research Council. Copenhagen, November 1997 Lise Pedersen 4
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Transcript of PREFACE
PREFACE
The major part of the present work was carried out in the Department of Oncology ONA at the Finsen Institute, Copenhagen, where I first worked as a House Officer, and afterwards as a Research Fellow from 1986-88 supported by the Danish Cancer Society. The investigation is based on patients with Medullary Carcinoma of the Breast registered in the Danish Breast Cancer Co- operative Group (DBCG), wherefrom the clinical data were kindly delivered. The pathological spe- cimens were kindly retrieved and delivered from pathological departments all over Denmark.
My interest in this particular kind of breast cancer was primarily encouraged by my former Chief Consultant Henning T. Mouridsen, Dr.Sci., M.D., to whom I am greatly indebted for his never failing support throughout the investigation and the following years of paper work.
I wish especially to thank my colleagues in pathology, Consultant Susanne Holck, DrSci., M.D. and Professor Torben Schiardt, DrSci., M.D., for their reviewing and reclassification of the histopathological specimens, for our inspiring and fruithl discussions, and for their support in general.
Abbrevations: MC TMC = Typical Medullary Carcinoma AMC = Atypical Medullary Carcinoma NMC = Non-Medullary Carcinoma IDC = Infiltrating Ductal Carcinoma IDC-NOS = Infiltrating Ductal Carcinoma
FCM = Flow Cytometry DI = DNAIndex SF CD = Cathepsin-D K19 = Keratin19 ICAM-1 = Intercellular adhesion molecule-1 LFA-1 = Integrin Lymphocyte-function-
associated Antigen DBCG
Group
= Medullary Carcinoma of the breast
Not Otherwise Specified
= Synthetic phase of cell cycle
= Danish Breast Cancer Cooperative
I am gratehl to Karin Zedeler from the DBCG for her expert help concerning the statistics and for good fellowship. I hrther should like to ex- press my thanks to the DBCG Secretariat for their always kind and willing cooperation.
I thank Jnrrgen Larsen, MSc, and Ib J. Christen- sen, MSc, of the Finsen Laboratory for their great work concerning the DNA profile.
In addition, I want to thank those of my collea- gues, whose discussions and support have been va- luable to me at different times during my work, especially Dr Carsten Rose and Dr Claw Kamby, my “room-mate” from the office of Research Fel- lows at the Finsen Institute. Last, but not least, I want to thank my scientific secretary during sev- eral years, Disa la Cour, for her skilled and always competent work, and for her friendship. I also thank Pia Hirsch, secretary to H.T. Mouridsen, for her kind and ready help whenever needed.
The study was supported financially by grants from the “Danish Cancer Society”, “Tnrmrerme- ster Otto V. Madsen og hustru Irma Madsen’s Fond”, and “Mogens Ambt Balslevs Mindefond”. The publication of the present review was sup- ported by the Danish Medical Research Council.
Copenhagen, November 1997 Lise Pedersen
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