Predicting response to interventions designed to sustain ...
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Predicting response to interventions designed to sustain tobacco abstinence postpartum
Michele D. Levine, PhD
Western Psychiatric Institute and Clinic
University of Pittsburg School of Medicine
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Smoking during Pregnancy• Pregnancy is common time for women to quit
• The majority of women who quit during pregnancy resume smoking within the first year postpartum
• Interventions designed to address postpartum smoking relapse can increase the rates of sustained abstinence postpartum
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Postpartum Relapse Prevention• The longer-term efficacy of postpartum relapse
prevention interventions is equivocal
• Rates of sustained abstinence vary from 23-72%
• Efforts to develop efficacious intervention might benefit from an understanding factors linked to outcome
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Predicting response to interventions• To date, several demographic factors have been
linked to smoking relapse
• Prenatal psychosocial characteristics may be linked to relapse
• Accordingly, in a trial designed to evaluate the relative efficacy of two interventions to prevent postpartum relapse, we examined the relevance of prenatal depressive symptoms and perceived stress to intervention response
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• Women (N = 300) who had quit smoking during pregnancy were randomized, prior to delivery, to postpartum-adapted interventions
• 6 month intervention
• Began at end of pregnancy
• Biweekly telephone and in person visits
• Women completed assessments at baseline 12-, 24-and 52-weeks postpartum
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STARTS vs. SUPPORT
Components STARTS SUPPORT
Face to face meetings (postpartum) 6 6
Telephone sessions 7 7
Support group offered Y Y
Begin at end of pregnancy and during high-
risk early postpartum period
Y Y
Gift vouchers for attendance at face to face
meetings
Y Y
Education about dangers of smoking Y Y
Discussion of urges to smoke Y Y
Education on mood, stress and weight
concerns
Y N
Cognitive behavioral skills to address
psychosocial mediators of relapse
Y N
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Participants (N = 300)Total
(N = 300)
Characteristic Mean (SD)
Age (years) 24.99 (5.65)
# Cigarettes/day 10.95 (9.35)
Years smoking 8.49 (5.65)
# previous quit attempts 3.50 (3.50)
FTND 3.20 (2.04)
Weeks quit at baseline 17.33 (11.73)
Prepregnancy BMI 27.28 (7.51)
% (n)
Race (% black) 54.3 (163)
Education level (% ≤ high school) 45.7 (137)
Household income (% < $30,000) 78 (234)
Parity (% nulliparous) 52 (156)
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Methods: Outcomes
• Biochemically-confirmed sustained tobacco abstinence weeks postpartum
• Timeline follow-back
• Expired-air CO
• Salivary cotinine
• Drop outs coded as smoking
• Depressive symptoms and stress at baseline (end of pregnancy), 12, 24 and 52 weeks postpartum
• EPDS
• CES-D
• Perceived stress
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Abstinence Rates
24-weeks postpartum
Total 53% (158)
Support 56.7%
STARTS 48.7%
52-weeks postpartum
Total 39% (117)
Support 40.7%
STARTS 37.3%
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Which intervention for whom
• Given that both interventions were equally successful, we wondered if demographic or psychosocial variables might help us understand who would benefit most from which postpartum adapted treatment
• Our work and that of others has documented the role of changes in mood and stress on postpartum abstinence
• We examined we examined baseline variables as moderators of treatment response
1. Demographic variables
2. Prenatal depressive symptoms and stress
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STARTS Moderation
• Demographic variables
• Age, race, educational attainment and length of quit during pregnancy related to abstinence
• Demographic variables did not moderate response to interventions
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Depressive symptoms and stress• Baseline depressive symptoms and perceived
stress interacted with treatment group to predict smoking status
• This interaction between baseline depressive symptoms and treatment group remained significant after adjusting for relevant covariates
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Depressive symptoms moderate intervention response
0
5
10
15
20
25
30
35
40
45
50
Time 12 Time 24 Time 52
% a
bsti
nen
t
STARTS-High
SUPPORT-High
STARTS-Low
SUPPPORT-Low
Moderation: Χ2 10.0, p = .001
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Abstinence by EPDS and intervention group
0
5
10
15
20
25
30
35
Time 12 Time 24 Time 52
% a
bsti
nen
t
STARTS-High
SUPPORT-High
OR=.19 (CI=0.04-0.83),p=.03
OR = .15 (CI=.03-.77), p=.02
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Abstinence by EPDS and intervention group
0
5
10
15
20
25
30
35
40
45
50
Time 12 Time 24 Time 52
% a
bsti
nen
t
STARTS-Low
SUPPPORT-Low
OR = 1.99 (CI =1.01-3.91), p =.05
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Abstinence by CES-D and intervention group
0
10
20
30
40
50
60
Time 12 Time 24 Time 52
% a
bsti
nen
t
STARTS-High
SUPPORT-High
STARTS-Low
SUPPPORT-Low
Moderation: Χ2 6.57, p = .01
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Abstinence by CES-D and intervention group
0
10
20
30
40
50
60
Time 12 Time 24 Time 52
OR=2.6(CI=1.2-5.7), p=.02
OR=2.5(CI = 1.1-5.7), p=.02
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Abstinence by PSS and intervention group
0
10
20
30
40
50
60
Time 12 Time 24 Time 52
% a
bsti
nen
t
STARTS-High
SUPPORT-High
STARTS-Low
SUPPPORT-Low
Moderation: Χ2 3.5, p = .06
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Abstinence by PSS and intervention group
0
10
20
30
40
50
60
Time 12 Time 24 Time 52
OR=2.5(CI=1.1-5.9), p=.03
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Summary
• Psychosocial factors at the end of pregnancy were associated with differential treatment response
• Women with low levels of prenatal depressive symptoms were more likely to sustain abstinence through one year postpartum when receiving a supportive, postpartum-specific relapse prevention intervention
• Women with higher levels of depressive symptoms at the end of pregnancy appear to benefit from CBT techniques that address mood and stress to sustain tobacco abstinence
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Conclusions
• Prenatal mood may be a useful in helping to select an approach to postpartum relapse prevention for women with minimal symptoms
• Given the relevance of postpartum smoking to the health of women, infants and children, additional efforts are needed to effectively intervene to sustain tobacco abstinence among all women
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Acknowledgments
Marsha D. Marcus, Ph.D. Melissa A. Kalarchian, Ph.D.Yu Cheng, Ph.D. Rebecca L. Emery, B.A., B.S.
Mallory P. Beatty, M.S. W. Jennifer Grace, M.A.Jackie Rosenstern, M.S.I.S. Betsy Butler, Ph.D. Meredith Strassburger, M.S.W. Gina Sweeny, M.S.Meghan S.C. Wisinski, B.A.
Research supported by:
R01 HD068802 (PI: Levine)
R01 DA021608 (PI: Levine)
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Participants Characteristics
Total
(N = 300)
STARTS
(n = 150)
SUPPORT
(n = 150)
STARTS
vs.
SUPPORT
CharacteristicMean
(SD)
Mean
(SD)
Mean
(SD)p
Age (years)24.99
(5.65)
24.97
(5.74)
25.01
(5.57)0.96
# Cigarettes/day10.95
(9.35)
10.35
(6.82)
11.55
(11.32)0.27
Years smoking 8.49 (5.65)8.49
(5.75)
8.49
(5.56)0.99
# previous quit attempts 3.50 (3.50)3.54
(3.88)
3.45
(3.08)0.84
FTND 3.20 (2.04)3.22
(2.01)
3.19
(2.07)0.89
Weeks quit at baseline17.33
(11.73)
16.42
(11.76)
18.21
(11.69)0.22
Prepregnancy BMI27.28
(7.51)
26.79
(7.15)
27.78
(7.85)0.26
% (n) % (n) % (n) p
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1,385 total calls
300 randomized
37 ineligible
25 smoked < 5 cigs/day
2 did not smoke daily
3 not motivated to stay quit
4 psychiatric diagnosis
2 moved out of area
1 death
150 CBT intervention 150 SBT intervention
1,126 screened
259 not screened
361 eligible
8 enrolled as pilots
859 interested
267 not interested
118 not pregnant
741 pregnant
105 never smoked
636 pregnant smokers
398 pregnant quitters
135 still smoking
72 quit for < one month
31 quit > 3 months prior to pregnancy
36 delivered before enrolled
17 miscarried before enrolled
Baseline assessment
150 Completed
12-week assessment
129 Completed
10 Not completed
24-week assessment
130 Completed
6 Not completed
52-week assessment
127 Completed
Baseline assessment
150 Completed
12-week assessment
139 Completed
3 Not completed
24-week assessment
137 Completed
5 Not completed
52-week assessment
139 Completed
5 lost to follow-up
2 withdrew
1 death of child
2 lost to follow-up
1 death of child
7 lost to follow-up
3 withdrew
1 death of child
2 lost to follow-up
1 incarcerated
8 lost to follow-up
1 withdrew
150 included in primary analysis 150 included in primary analysis
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Depressive symptoms and stress
STARTS
(n = 150)
SUPPORT
(n = 150)
STARTS vs.
SUPPORT
Mean (SD) Mean (SD) t p
CES-D 15.37 (9.87) 15.54 (9.89)
-
0.15 0.88
PSS 22.25 (8.63) 22.75 (7.91)
-
0.52 0.61
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Depressive symptoms and stress
Total
(N = 300)
STARTS
(n = 150)
SUPPO
RT
(n =
150)
STARTS
vs.
SUPPORT
Mean (SD) Mean (SD)
Mean
(SD) t p
CES-D 15.46 (9.88) 15.37 (9.87)
15.54
(9.89)
-
0.15 0.88
PSS 22.50 (8.27) 22.25 (8.63)
22.75
(7.91)
-
0.52 0.61