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Pre-Feasibility Report M/s. Ajanta Pharma Pvt. Ltd. 11KM Stone Gut No. 378, Plot No 8, Aurangabad –Pune Highway, Village-Waluj, Taluka. Gangapur, District. Aurangabad- 431133.

December 2017

Pre-Feasibility Report for M/s. Ajanta Pharma Ltd. at Village- Waluj, Taluka-Gangapur, District- Aurangabad

Page 1 of 38

Table of Contents

1. Executive Summary .......................................................................................................... 3

2. Introduction of the Project ............................................................................................... 5

I. Identification of project and project proponent: ............................................................... 5

II. Nature of the project. .................................................................................................... 5

III. Need of the Project and its importance to the country and or region .................................. 6

IV. Demand-Supply Gap ...................................................................................................... 7

V. Imports vs. Indigenous Production .................................................................................. 7

VI. Export Possibility ........................................................................................................... 8

VII. Employment Generation (Direct & Indirect) due to the project ........................................... 8

3. Project Description .......................................................................................................... 9

I. Type of Project including interlinked and interdependent projects ...................................... 9

II. Location of Project ........................................................................................................ 9

III. Details of Alternate Site ............................................................................................... 13

IV. Size or Magnitude of operation ..................................................................................... 13

V. Project Description with process details ......................................................................... 26

VI. Raw Material Required ................................................................................................ 27

VII. List of Plant Machineries .............................................................................................. 27

VIII. Resource optimization/recycling and reuse .................................................................... 27

IX. Availability of water its source, Energy/ power requirement ............................................ 27

X. Waste Generation & Management ................................................................................ 29

XI. Schematic representations of the feasibility drawing which give information of EIA purpose.

30

4. Site Analysis .................................................................................................................. 31

I. Connectivity ............................................................................................................... 31

II. Land Form, Land Use & Land ownership ......................................................................... 31

III. Topography ................................................................................................................ 31

IV. Existing Land use pattern ............................................................................................. 31

V. Existing Infrastructure .................................................................................................. 31

VI. Soil Classification ......................................................................................................... 32

VII. Climate data from secondary sources ............................................................................ 32

5. PLANNING BRIEF ............................................................................................................ 33

I. Planning Concept ........................................................................................................ 33

II. Population Projection .................................................................................................. 33


Page 2 of 38

III. Land use Planning........................................................................................................ 33

IV. Assessment of Infrastructure Demand ........................................................................... 34

V. Amenities/Facilities ..................................................................................................... 34

6. Proposed Infrastructure ................................................................................................. 35

I. Industrial Area ............................................................................................................ 35

II. Residential Area .......................................................................................................... 35

III. Green Belt .................................................................................................................. 35

IV. Social Infrastructure .................................................................................................... 35

V. Connectivity ............................................................................................................... 35

VI. Drinking Water ............................................................................................................ 35

VII. Sewerage System ........................................................................................................ 35

VIII. Industrial Waste Management ...................................................................................... 35

IX. Solid Waste Management ............................................................................................ 36

X. Power Requirement ..................................................................................................... 36

7. Rehabilitation and Resettlement (R & R) Plan ................................................................... 36

8. Project Schedule & Cost Estimates .................................................................................. 37

I. Likely date to start of Construction & likely date of completion ........................................ 37

II. Estimated Project Cost ................................................................................................. 37

9. Analysis of Proposal ....................................................................................................... 37

I. Financial & Social Benefits ............................................................................................ 37


Page 3 of 38

1. Executive Summary

Ajanta Pharma is a specialty pharmaceutical company engaged in development,

manufacturing and marketing of quality finished dosages. Ajanta operates 7 state-of-

the-art manufacturing facilities in India and Mauritius. One of the active

pharmaceutical ingredients (API) manufacturing unit is in operational namely M/s.

Ajanta Pharma Ltd. at 11KM Stone Gut No. 378, Plot No 8, Aurangabad –Pune

Highway, Village-Waluj, Taluka. Gangapur, District. Aurangabad- 431133.

Presently industry is involved in API manufacturing, which are used in drug

formulation mainly Anti-malerrial, Anti-inflammatory, Anlegesic, Treatment of

dyspepsia, Peptic ulcer diseases(PUD) & gastroesophageal reflux disease, Anti-

allergic, Antihistaminic, Antiglaucoma, Antithroboitic, Fibrinolytic, Anticoagulant,

Antilipemic, Antihypertensive, Antianginal, Antiarrhytmic, Anti-bacterial, Treatment

of Acute Coronary Syndrome, Anti-diabetic, In treatment of premature ejaculation,

Treatment of attention deficit hyperactivity disorder, chronic fatigue syndrome &

major depressive disorder, Dermatitis, Allergies, Antianginal, Glucocorticoid etc. The

existing consented manufacturing capacity is 21.042 MT/Month. Existing unit had

already obtained environmental clearance from Ministry of Environment, Forest &

Climate change vide letter no F. No. J-11011/ 359/ 2008-IA-II(I) dated 10th June 2009

(Annexure 1: EC Letter of existing unit)

Now, said industry has proposed for expansion with respect to manufacturing of

new products/molecules. In the proposed expansion total production quantity will

remain same as existing consented production quantity of 21.042 MT/Month. The

proposed products will be useful as active pharmaceutical ingredients for own drug

formulation unit as well as other units. Products has vide application in therapeutic

segments for treatment of patients hence it has demand in domestic as well as

international market.

As per the EIA Notification 2006 & its amendments thereof, for manufacturing of

Bulk Drugs & Intermediates chemicals requires environmental clearance from

MOEFCC under the 5(f) project activity.


Page 4 of 38

M/s. Ajanta Pharma Ltd. having total plot area 3200.50 Sqm. & total built up Area

2833.50 Sqm. vide MIDC sanction letter no. 1 20000001 51 0572 dated 03/09/2016.

For expansion purpose no any additional land acquisition & construction activity will

be involved.

Proposed expansion may require additional manpower but it will marginal i.e. 10-15

nos. In addition to that, additional fresh water of 20CMD will be required which will

be provided by MIDC, Waluj. Management has proposed to add auxiliary system viz.

2nos. of cooling tower of capacity 300TR & 120TR. Ajanta Pharma is very keen about

environmental protection hence they have proposed RO followed by Evaporator and

dryer system to adopt Zero Liquid Discharge (ZLD) scheme. The industry has

provided online monitoring system to ETP and connected to CPCB/MPCB servers in

compliance of MPCB circular no MPCB/ROA/1876/2015 dated 28/09/2015. At

present generated waste from industrial activity is being categorised as Hazardous &

non-hazardous and disposed-off through CHWTSDF, MEPL Ranjangaon &

authorised/approved vendor respectively. Ajanta Pharma has already developed

790.00 Sq.M. of area as green area out of 3200.50 Sq.M. of plot area. In addition to

that Ajanta Pharma acquired 1acre of land from Waluj grampanchayat adjacent to

existing unit and developed green belt.

The estimated total cost of the project after expansion would be ₹. 14.90 Cr which is

included existing project cost ₹. 13.40 Cr & proposed expansion cost ₹. 1.50 Cr.

Keeping in consideration the Environmental & Social safety, proposed expansion

activity involves manufacturing of active pharmaceutical ingredients thus following

studies are recommended such as Environment Impact Assessment (EIA),

Environment Management Plan (EMP), Disaster Management Plan (DMP), Risk &

Hazards study, Solid waste management, Public Consultation.


Page 5 of 38

2. Introduction of the Project

I. Identification of project and project proponent:

M/s. Ajanta Pharma Ltd. is an existing API manufacturing industry located at 11KM

Stone Gut No. 378, Plot No 8, Aurangabad –Pune Highway, Village-Waluj, Taluka.

Gangapur, District. Aurangabad- 431133. Industry is manufacturing products which

are mainly used for drug formulation such as cardiology, dermatology, and

ophthalmology and pain management. Now, industry has proposed to expansion of

existing manufacturing activities by adding new molecules in the process. Existing

consented manufacturing capacity is 21.042 MT/Month which will remain same i.e.

after proposed expansion total production capacity of unit would be 21.042

MT/Month. Proposed expansion will be in respect to addition of new

products/molecules and reduction in the existing product production quantity. There

is no acquisition of new land & other construction activity.

Ajanta Pharma Limited is an Indian pharmaceutical company that is headquartered

in Mumbai, Maharashtra, India. Established in 1973 by the Agrawal family, Ajanta

Pharma develops, manufactures and markets branded generics to emerging markets

in 30+ countries (across Asia, Africa, CIS, Middle East and SE Asia), and generics to

developed markets like USA. Ajanta pharma having 10 nos. of director group.

II. Nature of the project.

Presently industry is involved in API manufacturing, which are used in drug

formulation mainly Anti-malerrial, Anti-inflammatory, Anlegesic, Treatment of

dyspepsia, Peptic ulcer diseases(PUD) & gastroesophageal reflux disease, Anti-

allergic, Antihistaminic, Antiglaucoma, Antithroboitic, Fibrinolytic, Anticoagulant,

Antilipemic, Antihypertensive, Antianginal, Antiarrhytmic, Anti-bacterial, Treatment

of Acute Coronary Syndrome, Anti-diabetic, In treatment of premature ejaculation,

Treatment of attention deficit hyperactivity disorder, chronic fatigue syndrome &

major depressive disorder, Dermatitis, Allergies, Antianginal, Glucocorticoid etc. The

existing consented manufacturing capacity is 21.042 MT/Month. In the proposed

expansion production quantity will remain unchanged i.e. 21.042 MT/Month.


Page 6 of 38

III. Need of the Project and its importance to the country and or region

Now a day’s, rate of human health diseases is increasing rapidly. Medical treatment

with the help of drugs/medicines is a common practice in which medicines/drugs

play an important role in recovering the health & control the diseases.

Pharmaceutical industries require raw materials in the form of synthetic chemicals,

bulk drugs, intermediates to prepare final products as medicines. Bulk drug

intermediates are the active raw materials used in drugs that are useful as

therapeutic agents. Ajanta operates 7 state-of-the-art manufacturing facilities in

India and Mauritius. Out of 7 units 4 units are located in Aurangabad region viz.

Waluj, Chikalthana, Chittegaon & Paithan. Except Waluj remaining three units are

drug formulation units. Waluj unit is the only API unit and it is the source of raw

material to the other units. Demand of new medicine/ formulations increasing

rapidly in domestic as well international market in that case Waluj unit is inefficient

to supply all required API, hence Ajanta Pharma is purchasing required API from

other vendor which results in increase in cost of finished/final drug products.

Therefore, proposed expansion of Waluj unit is necessary.

The Indian pharmaceuticals market is the third largest in terms of volume and

thirteenth largest in terms of value, and it accounts for 20 per cent in the volume

terms and 1.4 per cent in value terms of the Global Pharmaceutical Industry as per a

report by Equity Master. India is the largest provider of generic drugs globally with

the Indian generics accounting for 20 per cent of global exports in terms of volume.

Many pharma companies succeed largely because their major operations are based

in Maharashtra. The government support received by the industry has been

substantial and the presence of a pragmatic and stable state government has been

one of the main reasons the state has managed to remain a principal destination for

all pharma companies whether Indian or MNC. Maharashtra has been a hub for the

pharma industry, both in terms of manufacturing as well as supply of materials.


Page 7 of 38

Aurangabad industrial belt occupies 40% of chemical producing industries for

pharma and other industries. In view of future market demand, it is best opportunity

to set up a business in Aurangabad which may lead to employment generation to

local youth and economical upliftment of local region.

IV. Demand-Supply Gap

The Indian pharmaceutical industry is the world's third-largest by volume and is likely

to lead the manufacturing sector of India. Several Government and private sector

projects with huge amount of investments have been initiated but could not attend

the speed of development for the need of good quality material. Over the last

decade, there has been a sizeable growth in Pharmaceutical sector both in small,

medium and large-scale units. This has given rise to many small and medium scale

units to manufacture pharmaceutical intermediates. The ever-growing requirements

of India, due to higher population and various diseases indicate the need for the

growth of this industry. Thus, there is a gap in demand and supply. Our efforts of

generating products, by-products, downstream products and recycling - reprocessing

are indeed needed. With multinational pharmaceutical companies enhancing their

presence in India, the long-term prospects of the pharmaceutical industry seem fairly

bright.

The fate of industrialization depends on the proper and effective conjugation of large

and medium/small scale industries each supporting each other in their requirement

to bridge the gap between demand and supply. In order to be competitive in the

global market this synergy between large & medium/small scale industries is a

prerogative. Therefore, considering the above, large companies do require the help

of small units to support them by giving them quality products at lesser price.

V. Imports vs. Indigenous Production

Nowadays Aurangabad known as pharma-hub. Most of the required raw materials

are sourced outside the Aurangabad for own formulation units. The proposed

expansion of Waluj unit will helpful to reduce raw materials requirement of bulk

drugs for Ajanta pharma units.


Page 8 of 38

VI. Export Possibility

Ajanta operates 7 state-of-the-art manufacturing facilities in India and Mauritius. 2

of the facilities in India have been successfully approved by US FDA. The company is

expanding its manufacturing capabilities to meet the growth requirement of the

future. The branded generics business is spread across India and more than 30

emerging countries in Africa, CIS, the Middle East and South-East Asia. The company

expects US market to be a key growth driver in the coming years. The Company's

Institutional business comprises of supplies to various government bodies in India

and supply of Anti-Malarial products under WHO approved programs in Africa.

Ajanta operates with 7 state-of-the art manufacturing facilities that produce high

quality pharmaceutical products. Currently one of the facility is already approved by

US FDA and another facility is in the process for the same. The company also

announced the Launch of Montelukast lR Tablets and Montelukast Chewable Tablets

in US market. Till date, the company has launched 12 products in the US Market. In

the FY 2015-16 the company has accomplished an international business accounting

to 69% of the total sale.

VII. Employment Generation (Direct & Indirect) due to the project

Proposed expansion is related to the addition of new molecules/products by utilising

existing infrastructure. There is no acquisition additional land or new construction

activity is involved hence manpower/ employment generation would be marginal i.e

10-15 nos.


Page 9 of 38

3. Project Description

I. Type of Project including interlinked and interdependent projects

Ajanta operates 7 state-of-the-art manufacturing facilities in India and Mauritius. Out

of 7 units 4 units are located in Aurangabad region viz. Waluj, Chikalthana,

Chittegaon & Paithan. Except Waluj remaining three units are drug formulation

units. Hence proposed expansion of Waluj API unit is indirectly interlinked with other

formulation units of Ajanta.

II. Location of Project

M/s. Ajanta Pharma Ltd. is an existing API manufacturing industry located at 11KM

Stone Gut No. 378, Plot No 8, Aurangabad –Pune Highway, Village-Waluj, Taluka.

Gangapur, District- Aurangabad- 431133. Location Map of the Project site is shown

in Exhibit No. 1. & site photographs are shown in Exhibit No.3. Site proximities are

presented in below Table No.1

Table No.1 : Site Proximities

Sr.No. Particulars Details

1. Project Location Waluj village adjacent to well-developed

Waluj MIDC area.

2. Geographical Coordinates Latitude : 19°48'19.28"N

Longitude : 75°13'42.68"E

Elevation : 516 meter above MSL

3. Nearest Highway Aurangabad-Ahmednagar : 300 meter

4. Nearest City/ Market Aurangabad-15 km

5. Nearest Fire Station Waluj Fire Station – 1.5 km

6. Nearest Airport Chikhalthana – 16.5 km

7. Nearest Railway Station Aurangabad- 10 km

8. Water Supply MIDC

9. Water Body Kham River- 1.4 km (East Direction)

Nagjhari River-6.6 km (West Direction)

Kohll River- 8.9 km (South Direction)


Page 10 of 38

Jogeshwari Talav – 1.8 km (NW Direction)

10. Common Effluent Treatment Plant Waluj – 3.5 km

Exhibit No. 1 : Index Map of Project Site

M/s. Ajanta Pharma Ltd.

Gut No. 378, Plot No 8, Aurangabad –Pune Highway, Village-

Waluj, Taluka. Gangapur, District- Aurangabad- 431133


Page 11 of 38

Exhibit No. 2 : Google Imagery of Project Site

Latitude: 19°48'17.91"N

Longitude: 75°13'43.77"E

Latitude: 19°48'19.31"N


Latitude: 19°48'21.18"N

Longitude: 75°13'43.28"E Latitude: 19°48'20.94"N


Latitude: 19°48'18.41"N



Page 12 of 38

Exhibit No.3: Plant Photographs


Page 13 of 38

III. Details of Alternative Sites

It is an expansion of the existing industry within the same premises hence alternative

sites are not examined or considered.

IV. Size or Magnitude of operation

At present industry is having consent from Maharashtra Pollution Control Board to

manufacture 85 nos. of product with total production capacity 21.042 MT/month

(Annexure 2- Copy of consent). In the proposed expansion industry will manufacture

256 nos. of products but the production quantity will remain same as existing i.e.

21.042 MT/month due to reduction in existing product quantity. Details of existing

and proposed production are presented below table

Table No. 2: Production Details

Sr. No

Name of Product

CAS No Existing/ New

Category of Product/ Therapeutic Use

Production Quantity ( MT/M) EC Required Quantity (MT/M)

Existing Proposed Total

1 i. Lumefantrine 82186-77-4 Existing Product

Antimalerial 2.5 -2.5 0 0

2 ii. Artemether 71963-77-4 Existing Product

3 i. Nepafenac 78281-72-8 Existing Product

Anti -inflammatory

2.8 -1.2 1.6 2.4 Either Individual Or Total

4 ii. Loteprednol Etabonate

82034-46-6 Existing Product

5 iii. Bromfenac Sodium


6 iv. Prednisolone Acetate


7 v. Tafluprost 209860-87-7 Existing Product

8 vi. Iguratimod 123663-49-0 Existing Product

9 vii. Desonide 21 - Phosphate


10 viii. Levobetaxolol HCl


11 ix. Apremilast 608141-41-9 Existing Product

12 x. Difluprednate 23674-86-4 Existing


Page 14 of 38

Product

13 xi. Mesalamine 89-57-6 Existing Product

14 xii. Nimesulide 51803-78-2 Existing Product

15 xiii. Indomethacin 53-86-1 Existing Product

16 xiv. Meclofenamate Sodium


17 xv. Fenspiride Chlorhydrate


18 xvi. Fluorometholone acetate


19 xvii. Roflumilast 162401-32-3 Existing Product

20 xviii. Mometasone Furoate Monohydrate


21 xix. Crisaborole 906673-24-3 New Product

0 0.8 0.8

22 xx. Polmacoxib 301692-76-2 New Product

23 xxi. Piclidenoson 152918-18-8 New Product

24 xxii. Lifitegrast 1025967-78-5

New Product

25 xxiii. Betaxolol HCL 63659-19-8 New Product

26 xxiv. Cyclosporine 59865-13-3 New Product

27 xxv. Dexamethasone 50-02-2 New Product

28 xxvi. Propyphenazone

479-92-5 New Product

29 xxvii. Dimethyl Fumarate


30 xxviii. Triamcinolone Hexacetonide


31 xxix. Apabetalone 1044870-39-4

New Product

32 i. Amtolmetin Guacil


Analgesic 1.1 -0.4 0.7 0.9 Either Individual Or Total

33 ii. Naproxcinod 163133-43-5 Existing Product

34 iii. Neramaxane Mesylate


35 iv. Tofacitinib Citrate


36 v. Nadifloxacin 124858-35-1 Existing Product

37 vi. Zucapsaicin 25775-90-0 Existing Product

38 vii. Nalbuphine 311768-81-7 New 0 0.2 0.2


Page 15 of 38

Sebacate Product

39 viii. Sufentanil Citrate


40 i. Penicillamine 52-67-5 New Product

Rheumatoid Arthritis

0 0.4 0.4 0.4 Either Individual Or Total

41 ii. Hydroxychloroquine Sulphate


42 iii. Baricitinib 1187594-09-7

New Product

43 iv. Benvitimod 79338-84-4 New Product

44 i. Ilaprazole 172152-36-2 Existing Product

Proton pump inhibitor


45 ii. Lansoprazole Sodium


46 iii. Lafutidine 118288-08-7 Existing Product

47 iv. Dexlansoprazole 138530-94-6 New Product

0 0.2 0.2

48 v. Omeprazole Sodium


49 vi. Tegoprazan 942195-55-3 New Product

50 i. Diquafosol Tetrasodium


Ophthalmic 0 0.1 0.1 0.1 Either Individual Or Total

51 ii. Omidenepag Isopropyl

1187451-19-9

New Product

52 i. Metaxalone 1665-48-1 New Product

Muscle relaxant

0 0.05 0.05 0.05

53 i. Rebamipide 90098-04-7 Existing Product

Gastritis 0.2 -0.1 0.1 0.1

54 i. Linaclotide 851199-59-2 New Product

Irritable bowel syndrome (IBS)


55 ii. Elobixibat 439087-18-0 New Product

56 i. Nitroglycerin 55-63-0 New Product

Acute prophylaxis of angina pectoris

0 0.05 0.05 0.05

57 i. Olopatadine HCL 140462-76-6 Existing Product

Antihistamine, Antiallergic


58 ii. Bilastine 202189-78-4 Existing Product


Page 16 of 38

59 iii. Bepotastine Besilate


60 iv. Tacalcitol MH 93129-94-3 Existing Product

61 v. Palonosetron HCL


62 vi. Flupirtine Maleate


63 i. Cetilistat 282526-98-1 New Product

Obesity 0 0.1 0.1 0.1

64 i. Silodosin 160970-54-7 Existing Product

Benign prostatic hyperplasia

0.1 0 0.1 0.2 Either Individual Or Total

65 ii. Fexapotide 492447-54-8 New Product

0 0.1 0.1

66 iii. Mirabegron 223673-61-8 New Product

67 i. Colestipol HCL 37296-80-3 New Product

Chronic diarrhea

0 0.1 0.1 0.1

68 i. Aripiprazole 129722-12-9 Existing Product

Antipsychotic 0.2 0 0.2 0.25 Either Individual Or Total

69 ii. Olanzapine 132539-06-1 New Product

0 0.05 0.05

70 i. Ropinirol HCl 91374-20-8 New Product

Parkinson's Disease

0 0.1 0.1 0.1

71 i. Latanoprost 130209-82-4 Existing Product

Antiglaucoma 0.12 0 0.12 0.5 Either Individual Or Total

72 ii. Brinzolamide 138890-62-7 Existing Product

73 iii. Bimatoprost 155206-00-1 Existing Product

74 iv. Ripasudil Hydrochloride Hydrate


0 0.38 0.38

75 v. Limaprost 74397-12-9 New Product

76 vi. Netarsudil 1254032-66-0

New Product

77 vii. Latanoprostene Bunod


78 viii. Travoprost 157283-68-6 New Product

79 ix. Brimonidine Tartrate


80 x. Tavilermide 263251-78-1 New Product


Page 17 of 38

81 i. Glycerol 56-81-5 New Product

Humectant 0 0.05 0.05 0.05

82 i. Cortexolone 17a-Propionate


Androgen receptor

0 0.05 0.05 0.05

83 i. Vilanterol trifenatate


beta2-adrenergic agonist

0 0.05 0.05 0.05

84 i. Rolapitant 552292-08-7 New Product

NK1 receptor antagonist

0 0.05 0.05 0.05

85 i. Varenicline Tartrate


Receptor antagonist

0 0.05 0.05 0.05

86 i. Ulipristal Acetate


Selective progesterone receptor modulator

0.05 0 0.05 0.05

87 i. Dabigatran Etexilate Mesylate


Anticoagulant 0.1 0 0.1 0.7 Either Individual Or Total

88 ii. Rivaroxaban 366789-02-8 New Product

0 0.6 0.6

89 iii. Edoxaban 480449-70-5 New Product

90 iv. Betrixaban 330942-05-7 New Product

91 v. Pentosan Polysulfate Sodium


92 vi. Elinogrel 936500-94-6 New Product

93 i. Divalproex Sodium


Anticonvulsant

0 0.05 0.05 0.05

94 i. Ursodiol 128-13-2 Existing Product

Antiviral 0.01 0 0.01 0.36 Either Individual Or Total

95 ii. Raltegravir Potassium


0 0.35 0.35

96 iii. Maraviroc 376348-65-1 New Product

97 iv. Daclatasvir Dihydrochloride

1009119-65-6

New Product

98 v. Valganciclovir 175865-59-5 New Product

99 vi. Simeprevir 923604-59-5 New Product


Page 18 of 38

100 i. Gemifloxacin Mesylate


Antibiotic 0.9 -0.25 0.65 1.65 Either Individual Or Total

101 ii. Minocycline HCL 13614-98-7 Existing Product

102 iii. Besifloxacin HCL 405165-61-9 Existing Product

103 iv. Retapamulin 224452-66-8 Existing Product

104 v. Sodium hyaluronate


105 vi. N-acetyl-L-carnosine


106 vii. Ospemifene 128607-22-7 New Product

0 1 1

107 viii. Ozenoxacin 245765-41-7 New Product

108 ix. Solithromycin 760981-83-7 New Product

109 x. Erythromycin Ethyl Succinate


110 xi. Moxifloxacin HCL


111 xii. Tobramycin 32986-56-4 New Product

112 xiii. Rifaximin 80621-81-4 New Product

113 xiv. Doxycycline Hyclate


114 xv. Doxycycline Monohydrate


115 xvi. Levofloxacin Hemihydrate


116 xvii. Sarecycline 1035654-66-0

New Product

117 xviii. Nemonoxacin 378746-64-6 New Product

118 xix. Flucloxacillin Sodium


119 xx. Amadacycline 389139-89-3 New Product

120 xxi. Omadacycline 389139-89-3 New Product

121 xxii. Finafloxacin hydrochloride


122 xxiii. Cethromycin 205110-48-1 New Product

123 i. Almotriptan 181183-52-8 New Product

Migraine 0 1 1 1 Either Individual Or Total

124 ii. Sumatriptan 103628-46-2 New Product

125 iii. Frovatriptan Succinate


126 iv. Lasmiditan 439239-90-4 New


Page 19 of 38

Product

127 v. Eletriptan HBr 177834-92-3 New Product

128 vi. Zolmitriptan 139264-17-8 New Product

129 vii. Rimegepant 1289023-67-1

New Product

130 viii. Sevelamer Carbonate


131 i. Aclidinium Bromide


Hypertension 2.51 -1.1 1.41 2.21 Either Individual Or Total

132 ii. Solifenacin Succinate


133 iii. Azelnidipine 123524-52-7 Existing Product

134 iv. Cilnidipine 132203-70-4 Existing Product

135 v. Azilsartan Medoxomil Potassium


136 vi. Metoprolol succinate


137 vii. Fimasartan Potassium Trihydrate

1020110-23-9

Existing Product

138 viii. Rosuvastatin calcium


139 ix. Efonidipine Hydrochloride Ethanolate


140 x. Olmesartan 144689-63-4 Existing Product

141 xi. Perindopril Arginine


142 xii. Phentermine Hydrochloride


143 xiii. Sacubitril 149709-62-6 New Product

0 0.8 0.8

144 xiv. Nifedipine 21829-25-4 New Product

145 xv. Chlorthalidone 77-36-1 New Product

146 xvi. Diltiazem Hydrochloride


147 xvii. Telmisartan 144701-48-4 New Product

148 xviii. Timolol maleate 26921-17-5 New Product

149 xix. Dalcetrapib 211513-37-0 New Product

150 xx. Valsartan 137862-53-4 New Product


Page 20 of 38

151 xxi. Ambrisentan 177036-94-1 New Product

152 xxii. Sacubitril-Valsartan


153 xxiii. Sacubitril-Telmisartan

NA New Product

154 i. Polaprezinc 107667-60-7 New Product

Treatment of peptic ulcer

0 0.05 0.05 0.05

155 i. Bempedoic Acid 738606-46-7 New Product

Hypercholesterolemia


156 ii. Cholestyramine 11041-12-6 New Product

157 i. Ivabradine HCL 148849-67-6 Existing Product

Antiseptic 0.2 -0.1 0.1 0.2 Either Individual Or Total

158 ii. Delmopinol Hydrochloride


0 0.1 0.1

159 iii. Octinidine HCL 70775-75-6 New Product

160 iv. Bibrocathol 6915-57-7 New Product

161 i. Lanthanum Carbonate


Hyperphosphatemia

0 0.05 0.05 0.05

162 i. Asenapine Maleate


Antipsychotic 0 0.1 0.1 0.1 Either Individual Or Total

163 ii. Clozapine 5786-21-0 New Product

164 i. Propafenone HCL


Antiarrhythmic agent

0 0.05 0.05 0.05

165 i. Deferasirox 201530-41-8 Existing Product

Chelating Agent


166 ii. Trientine Hydrochloride


0 0.05 0.05

167 i. Cinacalcet HCl 364782-34-3 New Product

Hyperparathyroidism

0 0.03 0.03 0.03

168 i. Tavaborole 174671-46-6 Existing Product

Antifungal 0.5 -0.1 0.4 0.6 Either Individual Or Total

169 ii. Efinaconazole 164650-44-6 Existing Product

170 iii. Luliconazole 187164-19-8 Existing Product

171 iv. Fenticonazole Nitrate


0 0.2 0.2


Page 21 of 38

172 v. Flucytosine 2022-85-7 New Product

173 vi. Voriconazole 137234-62-9 New Product

174 vii. Bremelanotide 189691-06-3 New Product

175 viii. Topiroxostat 577778-58-6 New Product

176 i. L- Methyl folate Glucosamine

1181972-37-1

Existing Product

Vitamin Supplement

0.2 -0.1 0.1 0.1

177 i. Odanacatib 603139-19-1 New Product

postmenopausal osteoporosis

0 0.02 0.02 0.02

178 i. Sapropterin Dihydrochloride


Coenzyme 0 0.04 0.04 0.04

179 i. Dendrimer 93376-66-0 New Product

Drug Delivery System

0 0.05 0.05 0.05

180 i. Colesevelam HCL


Anti-diabetic 1.2 -0.3 0.9 2.1 Either Individual Or Total

181 ii. Teneligliptin Hydrobromide Hydrate


182 iii. Sitagliptin Phosphate


183 iv. Alogliptin 850649-61-5 Existing Product

184 v. Vildagliptin 274901-16-5 Existing Product

185 vi. Linagliptin 668270-12-0 Existing Product

186 vii. Chiglitazar 743438-45-1 New Product

0 1.2 1.2

187 viii. Canagliflozin Hemihydrate


188 ix. Dapagliflozin Propanediol Monohydrate


189 x. Anagliptin 739366-20-2 New Product

190 xi. Trelagliptin Succinate

1029877-94-8

New Product

191 xii. Empagliflozin 864070-44-0 New Product

192 xiii. Ipragliflozin 761423-87-4 New Product

193 xiv. Saxagliptin 361442-04-8 New Product

194 xv. Mirogabalin 1138245-13- New


Page 22 of 38

2 Product

195 xvi. Sotagliflozin 1018899-04-1

New Product

196 xvii. Canagliflozin 842133-18-0 New Product

197 xviii. Dapagliflozin Propanediol


198 xix. Dapagliflozin 461432-26-8 New Product

199 xx. Lobeglitazone 607723-33-1 New Product

200 xxi. Luseogliflozin 898537-18-3 New Product

201 xxii. Tofogliflozin 1201913-82-7

New Product

202 xxiii. Gemigliptin 911637-19-9 New Product

203 xxiv. Evogliptin 1222102-29-5

New Product

204 xxv. Emixustat Hcl 1141934-97-5

New Product

205 xxvi. Retagliptin Phosphate

1256756-88-3

New Product

206 xxvii. Ertugliflozin 1210344-57-2

New Product

207 xxviii. Omarigliptin 1226781-44-7

New Product

208 xxix. Semaglutide 910463-68-2 New Product

209 i. Vardenafil HCL Trihydrate


Erectile dysfunction

2.7 -2 0.7 1 Either Individual Or Total

210 ii. Sildenafil citrate Mask complex

NA Existing Product

211 iii. Mirodenafil 862189-95-5 New Product

0 0.3 0.3

212 iv. Sildenafil citrate 171599-83-0 New Product

213 v. Tadalafil 171596-29-5 New Product

214 i. Dapoxetine HCL 129938-20-1 Existing Product

Platelet aggregation inhibitor


215 ii. Ticagrelor 274693-27-5 New Product

0 0.05 0.05

216 i. Voclosporin 515814-01-4 New Product

Immunosuppressant

217 i. Alcaftadine 147084-10-4 Existing Product

Antihistamine 0.1 0 0.1 0.2 Either Individual Or Total

218 ii. Azelastine HCL 79307-93-0 New Product

0 0.1 0.1


Page 23 of 38

219 iii. Cloperastine Fendizoate


220 i. Acotiamide Hydrochloride Hydrate


Postprandial 0.2 0 0.3 0.3

221 i. Obeticholic Acid 459789-99-2 New Product

Primary biliary cholangitis

0 0.05 0.05 0.05

222 i. Ibrutinib 936563-96-1 New Product

chronic lymphocytic leukemia

0 0.05 0.05 0.05

223 i. Pirfenidone 53179-13-8 New Product

Idiopathic pulmonary fibrosis

0 0.05 0.05 0.05

224 i. Vortioxetine HBr


Antidepressant 0 0.05 0.05 0.05

225 i. Hypochlorous Acid


Antimicrobial agents

226 ii. Apixaban 503612-47-3 New Product

227 i. Dienogest 65928-58-7 New Product

Endometriosis 0 0.05 0.05 0.05

228 i. Carboxymethyl cellulose sodium


Emulsifier 0 0.05 0.05 0.05

229 i. Hydroquinone 123-31-9 New Product

Hyperpigmentation

0 0.05 0.05 0.05

230 i. Pyridoxine HCL 58-56-0 New Product

Dietary supplement

0 0.05 0.05 0.05

231 i. Ivacaftor 873054-44-5 New Product

cystic fibrosis 0 0.05 0.05 0.05

232 i. Febuxostat 144060-53-7 Existing Product

Hyperuricemia 1.5 -1.3 0.2 0.3 Either Individual Or Total

233 ii. Lesinurad 878672-00-5 New Product

0 0.1 0.1

234 i. Netupitant 290297-26-6 New Product

Antiemetic 0 0.05 0.05 0.05

235 i. Indacaterol 753498-25-8 New beta- 0 0.05 0.05 0.05


Page 24 of 38

Maleate Product adrenoceptor agonist

236 i. Vilazodone Hydrobromide


Antidepressant 0 0.1 0.1 0.1 Either Individual Or Total

237 ii. Duloxetine Hydrochloride


238 i. Potassium Citrate


renal tubular acidosis

0 0.05 0.05 0.05

239 i. Alosetron HCL 122852-69-1 New Product

5-HT3 antagonist

0 0.05 0.05 0.05

240 i. Tizanidine HCL 64461-82-1 New Product

antispasmodic drugs

0 0.05 0.05 0.05

241 i. Isosorbide Mononitrate


angina pectoris

0 0.07 0.07 0.07

242 i. Entacapone 130929-57-6 New Product

Parkinson's disease

0.2 -0.15 0.05 0.05

243 i. Cytidine-5'-disodium monophosphate


Monomer in RNA

0 0.1 0.1 0.1 Either Individual Or Total 244 ii. Uridine

Diphosphate Disodium


245 i. Phloroglucinol Dihydrate


Antispasmodic 0 0.1 0.1 0.1 Either Individual Or Total

246 ii. Trimethyl Phloroglucinol


247 i. Spironolactone 52-01-7 New Product

Refractory edema

0 0.07 0.07 0.07

248 i. Triamcinolone Acetonide

76-25-5 New Product

Immunosuppressive

0 0.07 0.07 0.07

249 i. Vadadustat 1000025-07-9

New Product

Anemia and Non-dialysis

0 0.05 0.05 0.05

250 i. Suvorexant 1030377-33-3

New Product

Insomnia 0 0.08 0.08 0.08

251 i. Finerenone 1050477-31-0

New Product

Antimineralocorticoid

0 0.05 0.05 0.05


Page 25 of 38

252 i. Vilaprisan 1262108-14-4

New Product

Endometriosis 0 0.05 0.05 0.05

253 i. Olumacostat Glasaretil

1261491-89-7

New Product

Acne Vulgaris 0 0.06 0.06 0.06

254 i. Nolasiban 1477482-19-1

New Product

Pyrrolidinones 0 0.05 0.05 0.05

255 i. Picotamide 32828-81-2 Existing Product

Antiplatelet drug

1 -0.6 0.4 0.7 Either Individual Or Total

256 ii. Clopidogrel Bisulfate


Antiplatelet drug

0.5 -0.2 0.3

257 i. Montelukast Sodium


leukotriene receptor antagonist

0.2 0 0.2 0.2

258 i. R&D Project for study purpose

NA New Product

Not specific 0 0.3 0.3 0.3

21.042 21.042

Total EC Production 21.042


Page 26 of 38

V. Project Description with process details

In API chemical industry all production process take place in batches. Usually a reactor is

charged with raw materials and catalyst (if required) and then it is heated up to a certain

temperature to complete the reaction. On completion of the reaction, product gets

filtered/distilled and packed. Then the reactor is again ready for the next batch. Common

process flow diagram is presented in Figure No. 1

Figure No. 1 : Process Flow Diagram

Process Description:

Step 1: Wash the glass reactor before charging the batch

Step 2: Charge the reactor with raw materials as per defined size of batch

Step 3: Addition of catalyst as per process requirement

Step 3: Provide heating /chilling as per process requirement

Step 4: Allow the reaction for specified period

Step 5: Check by TLC for completion of reaction

Step 6: Recovery of solvent on completion of reaction

Step 7: Bring reactor temperature to room temperature

Step 8: Flirtation of the product

Step 9: Dry the final product ass per physical properties & packed it

Annexure 3:- Product wise process flow diagram & description.


Page 27 of 38

VI. Raw Material Required

In the proposed expansion 256 nos. of products will be manufactured hence

numerous raw materials will be required. Detailed product-wise raw materials

requirement is presented in Annexure 4.

VII. List of Plant Machineries

In API manufacturing industries various equipment are required on process to

process. It includes Reactor (glass & steel), Centrifuge, Dryer, Filter, Multimill,

Blender, Distillation Column, Heat Exchanger and auxiliary such as Boiler, Chiller,

Cooling Tower, Wet Scrubber, DG , Pumps, Air Handling unit etc. Detailed equipment

list with capacity & make is presented in Annexure 5.

VIII. Resource optimization/recycling and reuse

Proposed expansion is related to addition of new products only. Existing resources

such as infrastructure, equipment’s and manpower will be utilised in proposed

expansion. In proposed expansion industry will recycle waste water from cooling

tower, make up through ETP and propose RO & multiple effect evaporator system.

IX. Availability of water its source, Energy/ power requirement

Water

At present industry is consuming 40 KLD of water for industrial & domestic purpose.

After proposed expansion total water requirement would be 60 KLD and it will be

supplied by MIDC, Waluj. Detailed water budget is presented in below table

Table No. 3: Water Budget

Details of water Budget

Particulars Consumption (CMD) Loss (CMD) Waste Water (CMD)

Water Requirement

Existing Proposed Total Remark Existing Proposed Total Existing Proposed Total Remark

Domestic 5 0 5 Fresh 1 0 1 4 0 4 Sewage

Industrial Process

20 0 20 Fresh 4 0 4 16 0 16 Trade effluent

Cooling tower makeup

10 24.7 34.7 Fresh 20

Recycle 14.7 9.5 23.7 33.2 0.5 1 1.5

Trade effluent


Page 28 of 38

Boiler makup 5 7.5 12.5 Fresh -5

Recycle 7.5 4.5 6.8 11.3 0.5 0.7 1.2

Trade effluent

Gardening 0 8.5 8.5 Fresh 0 8.5 8.5 0 0 0

Washing 1.0 0 1.0 Fresh 0 0 0 1 0 1 Trade effluent

Scrubber 0.5 0 0.5 Fresh 0 0 0 0.5 0 0.5 Trade effluent

Total Water requirement

41.5 40.7 82.2 Fresh-60

Recycle-22.2 19 39 58 22.5 1.7 24.2

Effluent-20.2 Sewage-4

Figure No. 2: Water Balance Chart

Power

The total power requirement for industry is 450 kW. It is supplied by MSEDCL. In

case of Emergency, 400 kVA DG set is installed on the site which will be used to run

ETP, STP and common lights. Also, a seperate 100KVA DG will be installed for Zero

Liquid Discharge scheme.


Page 29 of 38

X. Waste Generation & Management

Construction Phase: There is no construction in proposed expansion hence no solid

waste generation.

Operation Phase: In operation phase generated solid waste is categorised as

hazardous & non-hazardous. Details of hazardous & non-hazardous are presented in

Table No. 3 & Table No.4, respectively.

Table No. 3: Details of Hazardous Waste

Hazardous Waste Generation Details

Sr. No.

Description Cat UOM Existing Proposed Total Method Of Disposal

1 Spent Oil/ used

waste 5.1 kg/month 25 5 30

Through authorised recycler/ reprocessor

2 Spent Solvents 20.2 kg/Month 7500 8000 15500 Sale to authorised

recycler/reprocessor

3 Distillation residue 20.3 kg/month 500 1300 1800 CHWTSDF

4 Spent Catalyst/ Spent Carbon

28.2 kg/month 500 250 750 CHWTSDF

5 Discarded containers

33.3 no. / Month 125 140 265 Sale to authorised

dealer

6 Sludge from waste water treatment

34.3 kg/month 150 50 200 CHWTSDF

7 Off specification

product 28.3 kg/month NA 1200 1200 CHWTSDF

8 Spent organic

solvent 28.5 kg/month NA 10000 10000

Sale to authorised recycler/reprocessor

Table No. 4: Details of Non-Hazardous Waste

Sr. No. Description UOM Existing Proposed Total Treatment

1 Wooden Material

Kg/M 200 200 400 Sale to Authorized recycler

2 Glass scrap Kg/M 200 200 400 Sale to Authorized recycler

3 HDPE Drums Nos/M 75 50 125 Sale to Authorized recycler

4 Plastic scrap

& Kachra Kg/M 100 100 200 Sale to Authorized recycler

5 Paper waste Kg/M 100 50 150 Sale to Authorized recycler

6 e-Waste Kg/A 0 100 100 Sale to Authorized recycler


Page 30 of 38

XI. Schematic representations of the feasibility drawing which give information of EIA

purpose.


Page 31 of 38

4. Site Analysis

I. Connectivity

The project site is adjacent to Waluj MIDC. It is well connected through road,

railway, and airport. Nearest highway is Aurangabad-Ahmednagar highway (MSH 60)

which is about 0.3 km from the project site. Nearest Railway station & Airport is in

Aurangabad which is at 10 km & 16.5 km respectively from project site.

II. Land Form, Land Use & Land ownership

M/s. Ajanta Pharama Ltd. was established in 2009 at Waluj village. Industry has

already operating API unit. Project site is spread in to 3200.50 Sqm. area. Land use is

for industrial activity only and land ownership is of Ajanta Pharma Ltd. Annexure 6-

7/12 extract of land.

III. Topography

M/s. Ajanta Pharma Ltd. is an already established unit. Topography of developed site

is flat. For expansion purpose, no any additional land or construction activity

required.

IV. Existing Land use pattern

Land is already developed for industrial purpose. Total plot area of M/s. Ajanta

Pharma Ltd. is 3200.50 Sqm. Site is located adjacent to well-developed Waluj MIDC

area. Surrounding area is already developed for industrial purpose.

V. Existing Infrastructure

Project site is having an existing infrastructure such as road, water supply, electricity

etc., other societal infrastructure around proximity of project site is presented in

Table No. 1.


Page 32 of 38

VI. Soil Classification

The most dominant type of soil found in the district is the black clay soil interspersed

with occasional stretches of shallow soils on ridges. In the north, the depth and

quality of soil is shallow and poor whereas in the south it is deep and fertile. A good

depth and fertile soil is particularly found in the Godavari valley. They are all derived

from Deccan trap. The soil can be classified as light, medium and heavy according to

the depth, texture and location.

VII. Climate data from secondary sources

Aurangabad has a semiarid climate. Annual mean temperatures in Aurangabad range

from 17 to 33 °C, with the most comfortable time to visit in the winter – October to

February. The maximum temperature ever recorded was 46 °C (114 °F) on 25 May

1905. The lowest recorded temperature was 2 °C (36 °F) on 2 February 1911. In the

cold season, the district is sometimes affected by cold waves in association with the

eastward passage of western disturbances across north India, when the minimum

temperature may drop down to about 2 °C to 4 °C (35.6 °F to 39.2 °F).

Most of the rainfall occurs in the monsoon season from June to September.

Thunderstorms occur between November to April. Average annual rainfall is 710

mm. The city is often cloudy during the monsoon season and the cloud cover may

remain together for days. The daily maximum temperature in the city often drops to

around 22 °C due to the cloud cover and heavy rains.


Page 33 of 38

5. PLANNING BRIEF

I. Planning Concept

In proposed expansion there will be no additional construction works involved.

Industry is in operation with 85 nos. of API. Existing industrial infrastructures are

adequate for proposed expansion. Hence no planning in detail will be required.

II. Population Projection

At present 70 nos. of manpower is working in the unit. During proposed expansion

10-15 nos. of additional manpower will be required which will be hired from nearby

villages on the basis of their educational qualification.

III. Land use Planning

Land is already developed for industrial purpose. Detailed land use is presented in

below table

Table No. 5 : Site Land Use

Sr.No. Description Area in Sq.M.

1. Plant Area 691.775

2. Utility 263.55

3. Store 103.70

4. 30.579

5. ETP Lab 24.912

6. ETP Area 242.512

7. Solvent Shed 101.81

8. Pump Room 39.872

9. 11KV Power Temple 44.917

10. Security Cabin 25.807

11. STP Plant 62.00

12. Solid Waste Storage Area 32.00

13. Garden 790.00

14. Parking 80.00

15. Road 300.00

16. Open Space 367.00

Total 3200.50


Page 34 of 38

IV. Assessment of Infrastructure Demand

Project site is already developed and adjacent to Waluj MIDC. Hence all

infrastructure is provided by the MIDC. Hence, no additional infrastructure will be

required.

V. Amenities/Facilities

In proposed expansion, additional 120 TR capacity cooling tower will be installed. To

achieve Zero Liquid Discharge (ZLD) Scheme, RO followed by Evaporator will be

instated at ETP.


Page 35 of 38

6. Proposed Infrastructure

I. Industrial Area

Project site is already developed for industrial purpose. In the proposed expansion

production quantity of unit will remain same as exiting i.e. 21.042 MT/month hence

no additional land or plot will be required for the expansion purpose.

II. Residential Area

No residential area is involved.

III. Green Belt

Industry has already developed 790.00 Sq.M. of area as a green area within

premises. In addition to that Industry has developed 4046.86 Sq.M. of private land

as a green belt adjacent to the unit.

IV. Social Infrastructure

No any additional infrastructure proposed as project is adjacent to Waluj MIDC.

V. Connectivity

As the existing industry is situated adjacent to Waluj MIDC it is well connected

through highway & internal roads. No new road is proposed.

VI. Drinking Water

Domestic water demand is 5 KLD and there is no additional requirement in proposed

requirement. Source of water is MIDC.

VII. Sewerage System

Existing industry has sewerage system for collection of domestic sewage. That

sewage is treated in sewage treatment plant having capacity 10CMD.

VIII. Industrial Waste Management

Industrial liquid waste i.e. trade effluent is being treated in ETP having capacity 25

KLD and treated effluent send to CETP for final disposal. In the proposed expansion

RO & Evaporator will be installed at ETP to adopt Zero Liquid Discharge Scheme.

Industrial solid waste segregated as hazardous & non-hazardous. Hazardous waste is

sent to CHWTSDF, MEPL Ranjangaon and non-hazardous waste is disposed-off

through authorized vendor/ recycler/reprocessor.


Page 36 of 38

IX. Solid Waste Management

Domestic waste categorized as dry & wet waste. Quantified dry waste 1.5 kg/day &

2.5 kg/day of wet waste are being collected at designated place and disposed-off

through authorized vendor.

X. Power Requirement

Existing power requirement is 450 kW and connected load is 720 kW. Source of

power is MSEDCL. Client has installed 400 kVA DG set for emergency power backup.

7. Rehabilitation and Resettlement (R & R) Plan

It is an existing project and for proposed expansion no additional land is required,

hence no R & R issue.


Page 37 of 38

8. Project Schedule & Cost Estimates

I. Likely date to start of Construction & likely date of completion

M/s. Ajanta Pharma Ltd. is already existing industry and existing infrastructure is

adequate for proposed expansion. For proposed expansion industry does not require

any construction activity. Manufacturing of proposed API will start after obtaining

Environment Clearance from MOEFCC & Consent to Operate from MPCB.

II. Estimated Project Cost

Estimated cost of the project for expansion purpose is ₹ 1.5 Cr for internal

modification, RO, Evaporator etc. Total cost of the project after expansion would be

₹ 14.90 Cr (Existing & Proposed).

9. Analysis of Proposal

I. Financial & Social Benefits

M/s. Ajanta Pharma Ltd., has proposed an expansion with respect to manufacturing

of new API, which will be used as a raw material for preparation of various medicines

for curing different diseases in social community & help maintain healthy life. Ajanta

has own drug formulation units in Aurangabad region hence proposed expansion will

reduce cost of outsourced API which ultimately results reduce in cost medicine

production. Thus, the project is having social benefit in terms of production of API

for medicines.

Considering financial point of view, proposed API can be exported to various

countries which will be beneficial to the company and the government.

Annexures

ANNEXURE-1

ANNEXURE-2

Mole Balance:

INPUTNo. of

molesMol.Wt. OUTPUT

No. of

molesMol. Wt.

(S)-4-(4-chlorophenyl)-2-pyridyl

methoxy piperidine 1 302.80 Bepotastine Besilate crude 1 547.07

Ethyl-4-bromobutyrate 1 195.05 Potassium Bromide 1 119.00

Potassium carbonate (powder) 1 138.20 potassium carbonate 1 138.20

Potassium iodide 1 166.00 Potassium iodide 1 166.00

Conc. Hydrochloric acid 1 36.46 Ethanol 1 46.07

Sodium hydroxide flakes 1 40.00 Sodium chloride 1 58.42

Acetic acid 2 120.10 Sodium acetate 1 82.03

Benzene sulfonic acid 1 158.18

Total Input = 1156.79 Total Output = 1156.79

CAS NO.:190786-44-8

Product Name : Bepotastine Besilate

Stage-1: Preparation of Bepotastine Besilate crude


N

O

NH

H

Cl

BrOC2H5

O

SO3H

N

O

NOH

O

Cl

HSO3H

.

Stage-1

(S)-4-(4-chlorophenyl)-2-pyridyl methoxy piperidine

K2CO3

Potassium CarbonateEthyl-4-bromobutyrate

(195) (138)

NaOH

Sodium Hydroxide

(40)

BenzeneSulfonic acid

(158)

KI

PotassiumIodide

(166)

HCl

Hydrochloric acid

(36.46)

2 CH3COOH

Acetic acid

(120.10)

(M.Wt: 302.80)

Bepotastine Besilate crude

(M.Wt: 547.07)

KBr

Potassiumbromide

(119)

K2CO3

Potassium Carbonate

(138)

KI

PotassiumIodide

(166)

C2H5OH

Ethanol

(46.07)

NaCl

Sodiumchloride

(58.42)

CH3COONa

Sodium acetate

(82.03)

ANNEXURE-3

Material Balance:

Kg OUTPUT Kg

Product

Stage-1 = 0.900

Recovery

Ethyl-4-bromobutyrate = 0.837 Acetone = 9.305

Acetone = 10.505 Acetone loss = 1.200

Potassium carbonate (powder) = 0.684 Dichloromethane = 7.985

Potassium iodide = 0.005 Dichloromethane loss = 1.990

Conc. Hydrochloric acid = 0.357

Isopropyl ether = 7.250 Aqueous

Sodium hydroxide flakes = 0.397 Effluent = 7.166

Ethyl acetate = 6.279

( Water+ HCl + Sodium

hydroxide + Acetic acid+

sodium chloride + Sodium

acetate )

Acetic acid = 0.735

Dichloromethane = 9.975 Waste solvent

Sodium sulphate = 1.000(Isopropyl ether + Ethyl

acetate + Acetonitrile)= 22.961

Acetonitrile = 9.432

Benzene Sulfonic acid = 0.460

Purified Water = 4.280 Inorganic Solid Waste

Inorganic Solid Waste = 1.689


INPUT

(S)-4-(4-chlorophenyl)-2-pyridyl

methoxy piperidine = 1.000

Stage -: 2

Mole Balance:

INPUTNo. of

molesMol.Wt. OUTPUT

No. of

molesMol. Wt.

Bepotastine Besilate crude 1 547.07 Bepotastine Besilate 1 547.07

Total Input = 547.07 Total Input = 547.07

Material Balance:

Kg OUTPUT Kg

Product

Bepotastine Besilate crude 0.900 Bepotastine Besilate = 0.800

Methanol 3.564 Recovery

Activated charcoal = 0.045 Methanol = 2.800

Hyflo supercel = 0.300 Methanol loss = 0.713

Acetone = 10.584

Mix Solvent

Effluent = 10.725

( Methanol + Acetone)

Solid Waste

(Activated charcoal + Hyflo

supercel)= 0.355


Stage-2: Preparation of Bepotastine Besilate

INPUT

=

PRODUCT NAME : BEPOTASTINE BESILATE

Description :

Condensation of (S)-4-(4-chlorophenyl)-2-pyridyl methoxy piperidine with Ethyl-4-bromobutyrate in Acetone

solvent by using Potassium carbonate base and Potassium Iodide catalyst at 55°C to 60°C and maintained

for 7 hour. After reaction completion distilled off Acetone under reduced pressure and charged dilute

Hydrochloric acid to make pH below 4.0. Reaction mass washed with Isopropyl ether and make pH basic of

reaction mass with dilute sodium hydroxide solution. Maintain for 2 hour at 25°C to 30°C, after reaction

completion treated with Ethyl acetate. pH was adjusted to 5.0 to 5.5 with acetic acid and product extracted in

Dichloromethane. Distilled off Dichloromethane completely under reduced pressure and in residue charged

Acetonitrile at 25°C to 30°C. Charged Benzene sulfonic acid in above acetonitrile clear solution. Stir for 12

hour and isolated the product by filtration at 5°C to 10°C, dried to get Bepotastine Besilate crude.

Dissolved Bepotastine Besilate crude in Methanol at 25°C to 30°C, after charcoal treatment filtrate distilled

off completely under reduced pressure at 45°C to 50°C. In residue charged Acetone slowly in 1-2 hour at

45°C to 50°C, cooled to 25°C to 30°C. Stir for 1 hour at 25°C to 30°C and isolated the product by filtration,

dried to get Bepotastine Besilate.

Stage-2: Preparation of Bepotastine Besilate Crude


N

O

NOH

O

Cl

HSO3H

.


(M.Wt: 547.07)

N

O

NOH

O

Cl

HSO3H

.

Bepotastine Besilate

(M.Wt: 547.07)

Stage-2

Product Name: Bepotastine Besilate

CAS No.: 190786-44-8


(S)-4-(4-chlorophenyl)-

2-pyridyl methoxy

Piperidine 1.0 kg

Acetone 9.408 kg

Potassium carbonate

Powder 0.684 kg

Potassium iodide 0.005 kg

Ethyl-4-bromobutyrate

0.837 kg

Acetone 1.097 kg Inorganic solid waste

0.689 kg

Acetone recovery

9.305 kg

Acetone loss 1.200 kg

Conc. Hydrochloric acid

0.357 kg

Purified Water 2.700 kg

Isopropyl ether 7.25 kg Isopropyl ether solvent

Waste 7.25 kg

Reactor

(Charging at 25°C to

30°C)

Nutche Filter

(Filtration at 25°C to

30°C)

Reactor


30°C)

Reactor

(Layer Separation)

Reactor


60°C)

Reactor

(Distillation at 55°C

to 60°C)

Reactor

(Stirring for 7 hour

at 55°C to 60°C)


Sodium hydroxide 0.397 kg

Ethyl acetate 6.279 kg Ethyl acetate 6.279 kg

Acetic acid 0.735 kg

Dichloromethane 9.975 kg Aqueous layer for ETP

5.769 kg

Sodium sulphate 1.000 kg Solid waste 1.000 kg

Dichloromethane recovery

7.985 kg

Dichloromethane loss

1.990 kg

Acetonitrile 7.86 kg

Benzene sulfonic acid

0.460 kg

Reactor


30°C)

Reactor

(Stirring for 2 hour

at 25°C to 30°C)

Reactor

(Layer Separation)

Reactor

(Charging for 2 hour

at 25°C to 30°C)

Reactor

(Layer Separation)

Reactor


to 50°C)

Reactor


30°C)

Reactor

(Stir for 12 hour at

25°C to 30°C)

Reactor

(Organic layer dry)

Acetonitrile 1.572 kg Acetonitrile ML for waste

Solvent 9.432 kg


0.900 kg



Crude 0.900 kg

Methanol 2.851 kg

Activated charcoal 0.045 kg

Hyflo super cel 0.300 kg

(For Hyflobed preparation)

Centrifuge / Nutche

Filter


10°C)

TD / VTD

(Drying at 60°C to

65°C)

Reactor


30°C)

Reactor

(Stirring at 25°C to

30°C)

Reactor


30°C)

Reactor

(Stir for 60 minute at

25°C to 30°C)

Methanol 0.713 kg Hyflo for solid waste 0.300 kg

Methanol recovery 2.800 kg

Methanol loss 0.713 kg

Acetone 7.056 kg

Acetone 3.528 kg Acetone ML for waste

Solvent 10.725 kg


0.800 kg

Nutche Filter

(Hyflo filtration at

25°C to 30°C)

Reactor


to 50°C)

Reactor


50°C)

Reactor

(Stir 60 minute at

45°C to 50°C)

Reactor

(Stir 60 minute at

25°C to 30°C)

Centrifuge / Nutche

Filter


30°C)

TD/VTD

(Drying at 60°C to

65°C)

Product Name: Besifloxacin HCl

CAS No. 1398566-43-2

Stage: Preparation of Besifloxacin HCl

Acetic acid 10.5 kg

BES-Amine 1.0 kg

Sulfuryl chloride 0.567 kg

Purified water 8.0 kg . Sulfur dioxide 0.267 kg

Waste water

Purified water 2.0 kg 21.225 kg

Purified water 2.0 kg

Hydrochloric acid solution

0.4 kg

Purified water 2.0 kg Wastewater 4.22 kg

Besifloxacin HCl 0.75 kg

Reactor

(Charged Water at

25°C to 30°C)

Reactor

(Charged at 25°C to

30°C)

Reactor

(Stirred at 25-30°C

for 2 h)

Nutsche

(filtration)

Reactor

(Besifloxacin Crude)

Reactor

(Stirred at 25°C to

30°C for 2 h)

Centrifuge/ Nutsche

(filtration)

TD/VTD

Drying

Stage : Preparation Besifloxacin HCl

Stage : Preparation Besifloxacin HCl

Mole Balance:

INPUTNo. of

molesMol. Wt. OUTPUT

No. of

molesMol. Wt.

1-Cyclopropyl-6-fluoro-7-(3-(R)-

Amino-hexahydro-1H-azepin-1-

yl)-4-oxoquinoline-3 -carboxylic

acid (BES-Amine)

1 359.16 1 429.465

Sulfuryl Chloride 1 134.97 Acetic acid 1 60.05

Acetic acid 1 60.05 Hydrochloric acid 1 36.50

Hydrochloric acid 1 36.50 Sulfur dioxide 1 64.660


Material Balance:

Kg OUTPUT Kg

Product

Stage-1 = 0.75

Recovery = —

Sulfuryl Chloride = 0.567 Aqueous

Acetic acid = 10.5 Effluent = 25.450

Hydrochloric acid (35%) = 0.4

Purified Water = 14.0

Organic Residue

Inorganic Solid Waste

Process Emissions

( Sulfur dioxide ) = 0.267


INPUT

1-Cyclopropyl-6-fluoro-7-(3-(R)-

Amino-hexahydro-1H-azepin-1-

yl)-4-oxoquinoline-3 -carboxylic

acid (BES-Amine)

= 1.0

Product Name: Besifloxacin HCl

CAS No. 1398566-43-2

( Acetic acid + Water from HCl + Water )

Acetic acid was taken in the reactor to which BES-amine was added at 25-30°C, fallowed by Sulfuryl chloride

addn.Stirred the reaction mass 2 hrs at 25-30°C. Then purified water added at 25-30°C. filtered solid washed

with water( Besifloxacin crude).

Besifloxacin crude was treated with Aq Hydrochloric acid at 25-30°C for 2 hrs at 25-30°C and centrifuge the

solid washed with water . Solid dried and to give Besifloxacin Hydrochloride.

Product Name : Besifloxacin HCl

Description :

Stage : Preparation of Besifloxacin HCl

SO2Cl2

HCl

CH3COOH

N

F

N

COOH

O

H2N

1-Cyclopropyl-6-fluoro-7-(3-(R)-Amino- Acetic acid Hydrochloric acid Sulfuryl chlorideHexahydro-1H-azepin-1- yl )-4-oxoquinoline-3-carboxylic acid (BES-Amine)

(M.Wt: 359.16) (60.05) (36.50) (134.97)

HCl

Besifloxacin Hydrochloride

(M.Wt:429.465) (60.05) (36.50) (64.66)

CH3COOH SO2

Acetic acid Hydrochloric acid Sulfur dioxide

Stage-I

N

F

N

COOH

O

H2N

Cl

.HCl

Mole Balance:

INPUTNo. of


No. of

molesMol. Wt.

BRI-Tosyl 1 566.7 Brinzolamide 1 383.5

Ethylamine 1 45.1 p-Toluenesulphonic acid 1 172.2

Water 1 18.0 Methyl acetate 1 74.1


Material Balance:

Kg OUTPUT Kg

Product

Brinzolamide = 0.50

Recovery

Ethyl amine (70%) = 1.00 Mixed solvent recovery = 2.10

Conc. Hydrochloric acid = 1.25 Mixed solvent loss = 0.15

Dichloromethane = 1.25 Methanol recovery = 0.60

Ethyl acetate = 1.00 Methanol loss = 0.15

Liquid Ammonia = 0.35 Aqueous

Methanol = 0.75 Water Effluent = 2.10

Organic Residue

Residue after solvent distillation = 1.00


BRI-Tosyl was stirred with ethylamine (70%) solution at 25°C to 30°C for 9-10h. The product was acidified

using Conc. Hydrochloric acid at 0°C to 5°C. Aqueous layer is extracted using Dichloromethane and Ethyl

acetate simultaneously. Aq. Layer was neutralized using Liq. Ammonia at 0°C to 5°C and stir for 8-9h at 25°C

to 30°C. Filtered the material at 0°C to 5°C to get crude product. Crude is recrystallized using methanol at

55°C to 60°C and filtered at 0°C to 5°C Wet material was dried to get desired quality of Brinzolamide

Proposed Name : Brinzolamide

CAS No.: 138890-62-7

Description :

Stage: Preparation of Brinzolamide

INPUT

BRI-Tosyl = 1.00

Product Name : Brinzolamide


(Water from HCl + Ethylamine + Liquid ammonia +

water)


NS S

HN

S

O O

O

NH2

O

O

NS S

O

S

O O

O

N

O

O

COCH3

S

O

O

CH3

BRI-Tosyl

HO

O COCH3S

O

O

CH3

( M.Wt : 566.69 )

C2H7N

Ethylamine

( 45 )

+ + H2O

Water

( 18 )

Brinzolamide

( M.Wt : 383.5 )

+

p-Toluenesulphonic acid

( 172 )

+

Methyl acetate

( 74 )

Stage

Product Name: Brinzolamide

CAS No.: 138890-62-7


BRI-Tosyl 1 kg

Ethylamine(70%) 1 kg

Conc. Hydrochloric acid 1.25kg

Dichloromethane 1.25 kg

Ethyl acetate 1 kg

Mixed solvent

2.1 kg

Distillation residue

0.1 kg

Liq. Ammonia 0.35 kg

Water Effluent

2.1 kg

Methanol 0.75 kg

ML Methanol

0.6 kg

(Reused)

Distillation residue

0.9 kg

Brinzolamide 0.5 kg

Reactor

(Reaction at 25°C to

30°C)

Reactor

(Reaction 0°C to 5°C)

Reactor

(Layer separation)

Reactor

(pH adjustment at

0°C to 5°C)

Centrifuge/Nutsche

filter

VTD/TD Reactor

(Distillation)

Reactor

(Distillation)

Reactor

Stage : 1

Mole Balance:

INPUTNo. of


No. of

molesMol. Wt.

7-(4-Bromobenzoyl)-1,3-dihydro-

2H-indole-2-one 1 316 Bromfenac sodium crude 1 383

Sodium Hydroxide 1 40

Water 1.5 27

Total Input = 383 Total Output = 383

Material Balance:

Kg OUTPUT Kg

Product

7-(4-Bromobenzoyl)-1,3-dihydro-

2H-indole-2-one = 1.000 Stage-1 = 0.900

Sodium Hydroxide = 0.230

Toluene = 5.982

Ethanol = 1.814

Isopropyl Ether = 7.250


Mix Solvent

(Toluene + Ethanol + Water +

Sodium hydroxide) = 16.000

Solvent loss during process 0.296


INPUT

Product Name: Bromfenac Sodium

Stage-1: Preparation of Bromfenac Sodium Crude

CAS No.:120638-55-3

O

Br

NH2

COONa

O

Br

HN

O

7-(4-Bromobenzoyl)-1,3-dihydro- 2H-indole-2-one

NaOH 1.5 H2O

(M.Wt : 316)

Stage-1

Sodium Hydroxide

(40)

Water

(27)

Bromfenac Sodium crude

(M.Wt: 383)

1.5 H2O

Stage : 2

Mole Balance:

INPUTNo. of


No. of

molesMol. Wt.

Bromofenac Sodium crude 1 383 Bromofenac Sodium 1 383


Material Balance:

Kg OUTPUT Kg

Product

Bromofenac Sodium crude = 0.900 Bromofenac Sodium = 0.645

1,2-dimethoxy ethane = 3.979 Recovery

Purified Water = 1.150 (1,2-dimethoxy ethane + Water) = 3.580

Toluene = 6.631(1,2-dimethoxy ethane + Water

loss)= 0.399

Ethanol = 2.011

Mix Solvent

(Toluene + Ethanol + Water +

organic residue)= 10.047


Stage-1 : Preparation of Bromfenac Sodium CrudeTo a stirred mixture of Toluene, Ethanol and 7-(4-Bromobenzoyl)-1,3-dihydro-2H-indole-2-one at 25° to 30°C, nitrogen purge

was started and maintained during the reaction. Sodium hydroxide as aqueous solution was added in one portion. The

solution was heated to reflux at 70°C to 75°C and continued for 3-4 hour. After reaction completion, reaction mass cooled to

0°C to 5°C and stirred for 1 hour at same temperature. Filter the product at 0°C to 5°C and wet cake washed with Isopropyl

ether and dried to get Bromofenac Sodium crude.

Bromfenac Sodium crude dissolved in 1,2 dimethoxy ethane and Purified Water mixture at 70°C to 75°C and filtered hot

through paper to remove insoluble material. Distilled off mixture of 1,2 dimethoxy ethane and Water at 45°C to 50°C under

reduced pressure and degassed. In residue charged Toluene and Ethanol and heated to 60°C to 65°C and stirred till clear

solution. Reaction mass was cooled to 0°C to 5°C and stirred for one hour. Filtered the product and dried to get Bromfenac

sodium.

Product Name : Preparation of Bromfenac Sodium

Description :

Stage-2 : Preparation of Bromfenac

INPUT

Stage-2:Preparation of Bromfenac Sodium

O

Br

NH2

COONa


(M.Wt: 383)

1.5 H2O

O

Br

NH2

COONa

Bromfenac Sodium

(M.Wt: 383)

1.5 H2O

Stage-2

Product Name: Bromfenac Sodium

CAS No.: 120638-55-3

Stage-1: Formation of Bromfenac Sodium Crude

Toluene 5.982 kg

Ethanol 1.814 kg

7-(4-Bromobenzoyl)-1, 3

-dihydro-2H-indole-2-

One 1.0 kg

Sodium Hydroxide 0.230 kg


Isopropyl ether 7.25 kg Waste solvent 16.00 kg


0.900 kg

Reactor


30°C)

Reactor


30°C)

Centrifuge/Nutsche


5°C)

Reactor


75°C)

Reactor

(Stir at 25°C to

30°C)

TD/VTD

(Drying)

Stage-2: Formation of Bromfenac Sodium

1, 2 dimethoxy ethane

3.979 kg


Bromfenac sodium crude

0.900 kg

1, 2-dimethoxy ethane

Recovery 3.58 kg

(Loss 0.399 kg)

Toluene 4.421 kg

Ethanol 1.341 kg

Toluene 2.210 kg

Ethanol 0.670 kg Waste solvent 10.047 kg


Bromfenac Sodium

0.645 kg

Reactor


30°C)

Reactor

(Stir at 70°C to

75°C)

Centrifuge/Nutsche

(Filtration)

Reactor

(Distillation)

Reactor


50°C)

Reactor

(Stir for 15-20

minute at 60°C to

65°C)

Centrifuge/Nutsche

(Filtration)

TD/VTD

(Drying)

Stage-1 : Preparation of CIL-Methoxy Benzylidene

Mole Balance:

INPUTNo. of


No. of

molesMol. Wt.

2-Methoxyethylacetoacetate[CIL-MEAA] 1 160 CIL-Methoxy Benzylidene 1 293

m-Nitro Benzaldehyde 1 151 m-Nitro Benzaldehyde 1 18

Piperidine 1 86 Piperidine 2 86

Acetic acid 1 60 Acetic acid 1 60


Material Balance:INPUT Kg OUTPUT Kg

Product

2-Methoxyethylacetoacetate[CIL-MEAA] = 1.000 CIL-Methoxy Benzylidene = 1.260

m-Nitro Benzaldehyde = 0.944 Recovery

Piperidine = 0.032 Toluene = 1.160

Acetic acid = 0.032 Toluene loss = 0.080

Toluene = 1.264 Isopropyl alcohol = 5.500

Isopropyl alcohol = 6.000 Isopropyl alcohol loss = 0.420

Organic Residue

After Distillation = 0.852

( Toluene+Isopropyl alcohol+ organic impurities)


Product Name : Cilnidipine

CAS No.: 132203-70-4

O

OHH3C

O

OH3C

2-Methoxyethylacetoacetate

CIL-MEAA

C7H5NO3NH2

Piperidine

CH3COOH

m-Nitro benzaldehyde Acetic acid

O

OH3C

O

OH3C

NO2

CIL-Methoxy benzylidene

H2ONH2

CH3COOH

Water Piperidine Acetic acid

( M.Wt : 160.2 ) ( 151.1) ( 86.1 ) ( 60.02)

( M.Wt : 293.3) ( 18.01) ( 86.1 ) ( 60.02)

Stage-I

Stage-2: Preparation of Cilnidipine Crude

Mole Balance:

INPUTNo. of


No. of

molesMol. Wt.

Cinnamyl acetoacetate ester [CIL-CAA] 1 218 Cilnidipine Crude 1 492.5

CIL-Methoxy Benzylidene 1 293 Ammonium bicarbonate 1 79

Ammonium carbonate 1 96.1 Water 2 36



Product

Cinnamyl acetoacetate ester [CIL-CAA] = 1.000 Cilnidipine crude = 1.54

CIL-Methoxy Benzylidene = 1.260 Recovery

Ammonium carbonate = 1.800 Dichloromethane = 2.500

p-Toluene Sulphonic acid (PTSA) = 0.180 Dichloromethane Loss = 0.500

Purified water = 6.000 Methanol = 14.400

Methanol loss = 1.100

Isopropyl alcohol = 4.840

Isopropyl alcohol loss = 0.160

Dichloromethane = 3.000 Aqueous

Methanol = 15.500 Effluent = 7.980

Isopropyl alcohol = 5.000

( Water + Ammonium Carbonate

+ Salt of PTSA )

Organic Residue

Unreacted Organic Impurities = 2.260


( Dichloromethane + Methanol + Organic impurities)

O

O

CH3O

Cinnamyl acetoacetate ester CIL-Methoxy benzylidene

O

OH3C

OO

H3CNO2 CH8N2O3

Ammonium carbonate

( M.Wt : 218.25) ( 293.27 ) ( 96.09)

N

O

O

H

O

OO

H3C

CH3H3C

NO2

Cilnidipine Crude Water Ammoniumbicarbonate

2H2O NH4HCO3

( M.Wt : 492.52) ( 36.02 ) ( 79.056)

Stage-II

Stage-3 :Preparation of Cilnidipine

Mole Balance:

INPUTNo. of


No. of

molesMol. Wt.

Cilnidipine Crude 1 492.5 Cilnidipine 1 492.5



Product

Cilnidipine Crude = 1.540 Cilnidipine = 1.320

Methanol = 13.800 Recovery

Methanol = 13.200

Methanol Loss = 0.600

Organic Residue

Organic Residue after distillation = 0.220


Description :

Stage-1 : Preparation of CIL-Methoxy Benzylidene

Stage-2: Preparation of Cilnidipine crude

Stage-3 :Preparation of Cilnidipine

Initially, Methanol was charged into the reactor & added Cinnamyl acetoacetate ester then added Ammonium carbonate and p-

Toluene Sulphonic acid at 25-30 °C. Maintained reaction mass at 25-30 °C for 18 h and filtered. Distilled out filtrate and

Dichloromethane and purified water were added and layer separation was done.Organic layer again distilled out to this distilled

mass CIL-Methoxy Benzylidene and Isopropyl alcohol were added. Then distillation was performed . Product isolated by adding

methanol to the concentrated mass. Centrifuged the mass after maintaining at 5-10 °C for 2 hours. Dried the filtered solid to get

Cilnidipine -Crude.

Initially, required quantity of methanol was taken in the reactor at RT and added Crude Cilnidipine . Heated the reaction mass to 50-

55oC. Maintained 30 min at 50-55

oC. Then the mass was cooled to 15-20

oC and maintained for 2 hr at 15-20

oC. The mass was

centrifuged to get pure Cilnidipine.

Toluene was used as a solvent. Initially, Toluene was taken in the reactor , under cooling added acetic acid and piperidine followed

by 2- Methoxyethyl acetoacetate at 25-30 °C. Then charged Nitro Benzaldehyde. Maintain the reaction mass at 100 °C to 110 °C for

5 hours. Distilled out reaction mass and charged IPA.Separated solid filtered through centrifuge and washed with chilled Isopropyl

alcohol. Use dried product for next stage.

N

O

O

H

O

O

OH3C

CH3H3C

NO2

N

O

O

H

O

O

OH3C

CH3H3C

NO2

Cilnidipine Crude Cilnidipine

( M.Wt : 492.5) ( M.Wt : 492.5 )

Stage-III

Product Name: Cilnidipine

CAS NO.: 132203-70-4

Stage-1: Preparation of CIL-Methoxy Benzylidene

CIL-Methoxyethyl

Acetoacetate 1.0 kg

Toluene 1.264 kg

Acetic acid 0.032 kg

Piperidine 0.032 kg

m-Nitro benzaldehyde 0.944 kg

Toluene 1.16 kg

(Reused)

Chilled Isopropyl alcohol 6 kg ML IPA 5.5

kg

Distillation Residue 0.034 kg

CIL-Methoxy Benzylidene

1.260 kg

Reactor

(Reaction)

Reactor

(Reaction)

Reactor

(Distillation)

Reactor

(Crystallization &

Centrifugation)

Centrifuge/Nutsche

filter

Reactor

(Distillation)

TD/VTD

(Drying)

Stage-2: Preparation of Cilnidipine crude

Cinnamyl acetoacetate ester 1.0 kg

Methanol 8 kg

Ammonium Carbonate 1.8 kg

P-Toluene Sulphonic acid 0.18 kg

Ammonium bicarbonate

Waste 1.48 kg

Methanol 8.4 kg

(Reused)

Dichloromethane 3 kg

Waste water

Purified Water 6 kg 6 kg


(Reused)

CIL-Methoxy Benzylidene 1.26 kg

Isopropanol 5 kg

Isopropanol 3.84 kg

(Reused)

Reactor

(Reaction)

Reactor

(Reaction)

Centrifuge/Nutsche

Filter

Reactor

(Distillation)

Layer separation

Reactor

(Distillation)

Reactor

(Reaction)

Reactor

(Distillation)

Methanol 7.5 kg

ML

` Methanol

. 6 kg

(Reused)

Distillation Residue 1.48 kg

Cilnidipine Crude

1.540 kg

Reactor

(Isolation)

Centrifuge/Nutsche

Filter

Reactor

(Distillation)

TD/VTD

(Drying)

Stage-3: Preparation of Cilnidipine

Cilnidipine crude 1.54 kg

Methanol 13.8 kg

Methanol

12.2 kg

(Reused)

Cilnidipine

1.320 kg

Reactor

(Purification)

Centrifuge/Nutsche

Filter

Reactor

(Distillation)

TD/VTD

(Drying)

Mole Balance:

INPUTNo. of


No. of

molesMol. Wt.

1 467 Difluprednate 1 509

Pyridine 1 79

Pyridine 1 79 Hydrochloric acid 1 36

Acetyl Chloride 1 79


Material Balance:

Kg OUTPUT Kg

Product

Difluprednate = 0.95

Recovery

Pyridine = 0.30 Ethyl acetate = 4.50

Acetyl Chloride = 0.20 Ethyl acetate loss = 0.50

DMF = 0.40 Isopropyl ether = 4.50

Ethyl Acetate = 5.00 Isopropyl ether loss = 0.50

Isopropyl Ether = 5.00

Activated Charcoal = 0.20 Aqueous

Hyflo = 0.20 Water Effluent = 7.30

Water = 7.00

Organic Residue


Inorganic Residue = 0.40

charcoal + Hyflo


(Water from HCl + Water + Pyridine + salt)

To the solution of 6a, 9-Difluoro-11b, 17, 21-trihydroxypregna-1, 4-diene-3, 20-dione 17-butyrate and pyridine

was added slowly Acetyl chloride at 20°C to 30°C in 1 to 1.5h.The reaction was maintained for 1h at 20°C to

30°C for completion of reaction. Crude material was filtered at 20°C to 30°C. Crude material was charcoalized in

DMF at 20°C to 30°C for 1h. Filtrate was precipitated by water at RT and stirred for 1h. Filtered product was

washed by Isopropyl ether to get desired product Difluprednate.

Product Name : Difluprednate

Description :

Stage: Preparation of Difluprednate

INPUT

6a , 9-Difluoro-11b,17,21-

trihydroxypregna-1,4-die 3,20-

dione 17-butyrate (KSM)

= 1.00

Product Name: Difluprednate

6a , 9-Difluoro-11b,17,21-

trihydroxypregna-1,4-die 3,20-

dione 17-butyrate (KSM)

CAS NO.: 23674-86-4



O

CH3

HOCH3

F

F

O

O

CH3

O

OH

O

CH3

HOCH3

F

F

O

O

CH3

O

O

O

6a , 9-Difluoro-11b,17,21-trihydroxypregna-1,4-die 3,20-dione 17-butyrate

Difluprednate

(Mol. Wt.: 466.51)

O

Cl

Acetyl Chloride

(78.5)

N

Pyridine

(79.1)

+ +

N

+ +H Cl

Hydrochloric acidPyridine

(36.46)(79.1)( 508.55)

Product Name: Difluprednate

CAS No.: 23674-86-4


KSM 1.0 kg

Pyridine 0.3 kg

Acetyl chloride 0.2 kg

Ethyl acetate 5.0 kg

Water 1.0 kg

Ethyl Acetate recovery (4.5 kg)

Water Effluent 1.3 kg

Residue 0.25 kg

Isopropyl Ether 3.0 kg IPE recovery

2.25 kg

Residue 0.2 kg

Dimethyl Formamide 0.4 kg

Charcoal 0.2 kg

Hyflo 0.2 kg Recovered charcoal + Hyflo

0.4 kg

Water 3.0 kg

Isopropyl Ether 2.0 kg

Water 3.0 kg Water Effluent 6.0 kg

IPE recovery 2.25 kg

Residue 0.2 kg

Difluprednate

0.95 kg

Reactor

(Acylation at 20°C

to 30°C)

Reactor

(Quenching)

Centrifuge/Nutsche

Filter

Reactor

(Washing)

Reactor


30°C)

Centrifuge/Nutsche

Filter

Reactor

(Filtrate)

Centrifuge/Nutsche

Filter

TD/VTD

Reactor

(Distillation)

Stage-1 : Preparation of Febuxostat crude

Mole Balance:

INPUTNo. of

molesMol. wt. OUTPUT

No. of

molesMol. Wt.

2-(3-Cyano-4-

isobutyloxyphenyl)-4-

methylthiazole-5-carboxylic

1 344.43 Febuxostat Crude 1 316.37

Sodium Hydroxide flakes 1 40.00 Ethanol 1 46.12

Hydrochloric Acid 1 36.50 Sodium chloride 1 58.44


Material Balance:

Kg OUTPUT Kg

Product

Febuxostat Crude = 0.854

Recovery

Tetrahydrofuran = 2.00 = 3.60

Methanol = 2.00

Sodium Hydroxide flakes = 0.120

Acetone = 5.50 Tetrahydrofuran + Methanol Loss = 0.400

Purified water = 9.50

Hydrochloric acid = 0.20

Aqueous

Effluent = 15.466


( Water from HCl + Water + Sodium chloride )

Product Name : Febuxostat

INPUT

2-(3-Cyano-4-



acid ethyl ester (FEB-Ester) = 1.0


CAS No. 144060-53-7

Tetrahydrofuran + Methanol Mixture

distillate

ON

S

CH3

COOC2H5NC

ON

S

CH3

COOHNC

Febuxostat Crude

Feb-Ester

NaOH

THF/Methanol

(Mol.Wt. 344.43)

(316.37)

+

Sodium Hydroxide

(40)

+

( 46.12)

+NaCl

sodium chloride

( 58.44)

HCl+

Hydrochloric acid

(36.5)

C2H5OH

Step-I

Ethanol

Stage : 2

Mole Balance:

INPUTNo. of

molesMol. wt. OUTPUT

No. of

molesMol. Wt.

Febuxostat Crude 1 316.37 Febuxostat 1 316.37


Material Balance:

Kg OUTPUT Kg

Product

Febuxostat Crude = 0.854 Febuxostat = 0.828

Acetone = 5.50

Purified water = 7.50

Aqueous

Effluent = 12.600


Charged Tetrahydrofuran, 2-(3-Cyno-4-isobutyloxyphenyl)-4-Methylthaizole-5-carboxylic acid ethyl ester and Methanol and

added aqueous Sodium Hydroxide solution. stirred for 5-6 hrs at 28°C to 32°C.Distilled out solvent at 35°C to 40°C and cooled

at 25-30°C.Carged Acetone and adjusted the pH 2 to 3 by aqueous Hydrochloric acid solution at 25°C to 30°C. Stirred at 25°C

to 30°C for 35-45 min and filtered the product washed with water, suck dry the wet cake, Dried the solid product.

Crude Febuxostat purified in Acetone and Water mixture at 25-30°C .Filtered product washed with purified water to get pure

Febuxostat and dried the product.

Product Name : Preparation of Febuxostat

Description :

INPUT

( Water + Acetone + Organic residue )

Product Name : Febuxostat

Stage-2 : Preparation of Febuxostat


Stage-2 : Preparation of Febuxostat

Solvent loss during process = 0.426

Febuxostat

Acetone / Water

O

N

S

CH3

COOH

NC

O

N

S

CH3

COOH

NC

Febuxostat Crude

(Mol. Wt. 316.37) (Mol. Wt 316.37)

Step -II

Product Name: Febuxostat

CAS No. 144060-53-7

Stage-1: Preparation of Febuxostat Crude

2-(3-Cyano-4-isobutyloxyphenyl)

-4-methylthiazole-5-carboxylic

Acid ethyl ester (FEB-Ester)

1.0 kg

Tetrahydrofuran 2.0 kg

Aq.Sodium Hydroxide

[0.12 kg in 5.5 kg water]

Methanol 2.0 kg

Distillate

Methanol +THF

3.6 kg

Acetone 5.5 kg

Aqueous Hydrochloric Acid

[0.2 kg HCl in 2.0 kg water]

Water 2.0 kg ML

For Washing Aq.Acetone

15.466 kg

Febuxostat crude

0.854 kg

Reactor

(Charged Batch)

Centrifuge/Nutsche

(Filtration)

TD/VTD Drying

Reactor


32°C for 5 to 6 h).

Reactor

(Cooled at 25°C to

30°C)

Reactor

(Distillation U/V at

35°C to 40°C)

Reactor


30°C for 35-45 min)

Reactor

(pH 2 to 3

Adjustment)

Stage-2: Preparation of Febuxostat

Febuxostat crude 0.854 kg

Acetone 5.0 kg


ML

Aq.Acetone 11.8 kg

Water + Acetone ML

(0.5+0.5 kg) Aq. Acetone 0.8 kg

Febuxostat

0.828 kg

Reactor

(Charged at 25°C to

30°C)

Reactor


30°C for 1 h)

Centrifuge/Nutsche

(Filtration

)

TD/VTD

Drying

Wet Cake

Stage: Preparation of Ilaprazole

Mole Balance:

INPUTNo. of


No. of

molesMol. Wt.

Ilaprazole Sodium 1 388.42 Ilaprazole 1 366.44

Acetic acid 1 60.05 Sodium Acetate 1 82.03


Material Balance:

Kg OUTPUT Kg

Ilaprazole Sodium = 1.00 Product

Acetic acid = 0.15 Ilaprazole = 0.86

Water = 1.50 Aqueous = 12.30

Ethanol = 10.85

Residue = 0.35

(Organic + inorganic residue)


Stage: Preparation of IlaprazoleIlaprazole sodium was treated with Acetic Acid in Ethanol at 25°C to 30°C, initially material was soluble in

Ethanol after that solid start to precipitate out at 0°C to 5°C. Maintained reaction mass for 1 to 2 h at 0°C to

5°C and then filtered solid and washed with Ethanol, 25% Ethanol in water to removed organic salts and again

with Ethanol. Dried the wet material to get Ilaprazole.

Product Name : Ilaprazole

Description :

( Water effluent: Ethanol + Water + Acetic acid)

INPUT

Product Name: Ilaprazole

CAS No.: 172152-36-2


NNa

N

S

N

N

O

O

NH

N

S

N

N

O

O

Acetic AcidIlaprazole Sodium

Ilaprazole

O

OH

O

ONa

Sodium Acetate

(Mol. Wt.: 388.42)

(Mol. Wt.: 366.44)

(60.05)

(82.03)

Product Name: Ilaprazole

CAS No.: 172152-36-2


Ethanol 5 kg

Ilaprazole sodium 1 kg

10 % Acetic acid in Ethanol

1.5 kg

Chilled Ethanol wash 2 kg

25 % Ethanol in water 2 kg Water Effluent

Chilled Ethanol wash 2 kg 12.3 kg

Residue 0.35 kg

Ilaprazole 0.860 kg

Reactor


30°C)

0

Reactor

Reactor

(Stir 1 to 2 hour at 0°C to -5°C)

Centrifuge/Nutsche

Filter

Reactor

(Distillation)

VTD/TD

Stage-1: Preparation of LOT-Ester

Mole Balance:

INPUTNo. of


No. of

molesMol. Wt.

LOT-Ester 1 346.0 LOT-Ester 1 418.0

Pyridine 1 79.0 Pyridinium hydrochloride 1 115.0

4-DMAP 1 122.0 4-DMAP 1 122.0

Ethyl Chloroformate 1 108.0


Material Balance:

Kg OUTPUT Kg

LOT-KSM = 1.0 Product

Dichloromethane = 3.5 Loteprednol Etabonate = 1.027

Pyridine = 0.57 Recovery

4-Dimethyl amino pyridine = 0.02 Mixed solvent recovery = 3.8

Ethyl Chloroformate = 0.34 Mixed solvent loss = 1.7

Aq. HCl solution = 22.30 Mixed solvent recovery = 15.3

Pet-ether = 17.00 Mixed solvent loss = 2.70

Ethyl acetate = 3.0

Aqueous

Water Effluent = 23.10

Organic Residue

Residue after solvent recovery = 0.1


INPUT

Product Name: Loteprednol Etabonate

CAS No.: 82034-46-6


(Aq. HCl and Residue salt)

HOO

O

CH3

CH3 H

H H

OHHO

HOO

O

CH3

CH3 H

H H

OCOOEtHO

LOT-KSM

LOT-Ester

+N

+ 4- DMAP ClCOOEt+

Pyridine 4-Dimethyl amino pyridine

Ethyl chloroformate

4- DMAP+

N HCl

Pyridinium hydrochloride 4-Dimethyl amino pyridine

+

(M.Wt.-346) (79) (122) (108)

(M.Wt.-418) (115) (122)

Stage-I

INPUTNo. of


No. of

molesMol. Wt.

LOT-Ester 1 418 Loteprednol Etabonate 1 466.9

Potassium carbonate 1 138 Potassium bicarbonate 1 100

Chloroiodomethane 1 176.9 Potassium iodide 1 166


Material Balance:

Kg OUTPUT Kg

LOT-Ester = 0.91 Product

Potassium carbonate = 0.55 Loteprednol Etabonate = 0.978

Dimethylformamide = 9.10 Recovery

Chloroiodomethane = 1.53 Pet ether = 5.2

Acetone = 22.00 Pet ether loss = 1.2

Water = 41.0 Acetone = 17.60

Pet ether = 6.4 Acetone loss = 4.4

Aqueous

Water Effluent = 50.7

(Water and inorganic residue)

Organic Residue

Organic residue after solvent

recovery= 1.4


Stage-2: Preparation of Loteprednol Etabonate

Mole Balance:


Description:

To the mixture of Dimethylformamide, LOT-Ester and Potassium carbonate was added slowly Chloroiodomethane

at 25°C to 30°C. The reaction mass was stirred at 25°C to 30°C for 2h. After completion of reaction chilled water

and Pet Ether was added and stirred for 60-90 min at 25°C to 30°C. Material was filtered and washed with water

and was suck dried well. The wet cake was taken in Acetone and heated to 45°C to 50°C for 1h and then cooled

slowly to 0°C to 5°C. Product was filtered to get Loteprednol Etabonate.


Stage-1: Preparation of LOT-EsterReaction mixture of Dichloromethane, 11-Beta, 17-Alpha-Dihydroxy-3-Oxoandrost-1, 4-Diene-17-Carboxylic acid

(LOT-KSM), pyridine and 4-(Dimethyl)-Amino-Pyridine was stirred at 25°C to 30°C for 15 min. Ethyl chloroformate

was added slowly to reaction mass at 0°C to 5°C. After completion of reaction aqueous Hydrochloric acid and Pet

ether was added stir for 2 h. Filter and suck dry. Charged wet cake in ethyl acetate and stirred at 25°C to 30°C,

slowly Pet Ether was added to reaction mass at 45°C to 50°C and stirred at 45°C to 50°C for 1 h then cooled at

25°C to 30°C, filtered and suck dry. Dry the wet cake to get LOT-Ester.

INPUT


CIH2COO

O

CH3

CH3 H

H H

OCOOEtHO

Loteprednol Etabonate

HOO

O

CH3

CH3 H

H H

OCOOEtHO

LOT-Ester

(M.Wt.-418)

K2CO3 CICH2I+ +

Potassium carbonate Chloroiodomethane

(138) (176)

KHCO3 KI

Potassium bicarbonate

Potassium iodide

(M.Wt.-467) (100) (166)

Stage-2


CAS No.: 82034-46-6



LOT-KSM 1 kg

Pyridine 0.57 kg

4- DMAP 0.02 kg

Ethyl chloroformate

0.34 kg

Aq. HCl 22.3 kg

Pet Ether 2 kg


Pet ether 15 kg

Reactor

(Stirring at 25°C to 30°C for 15

mins)

Reactor

(RM Chilled at 0°C to 5°C under

stirring)

Reactor

(Addition at 0°C to 5°C)

Reactor

(Raise Temp. 25°C to 30°C)

Reactor (Stir at 25°C to 30°C)

Centrifuge/Nutsche Filter

Reactor

(Wet cake)

Reactor

(Stir 20 minute at 25°C to 30°C.)

Reactor

(Heat at 45°C to 50°C for 1 hour)

Mixed solvent recovery

3.8 kg + Residue 0.05 kg

Aqueous effluent

23.10 kg

Reactor (Distillation)

Reactor

(RM Cool at 25°C to 30°C under

stirring)


(Filtration)

TD/VTD

(Drying)

Residue

0.05 kg

ML for

distillation

Mixed solvent

recovery 15.3 kg

LOT- Ester 1.027 Kg


Reactor

(RM Stirring at 25°C to 30°C for

15 minutes)

Reactor


Reactor

(RM Stir for 1 h at 25°C to 30°C)

Reactor


Reactor

(RM Stirred for 2 hours at 25°C

to 30°C)

Reactor

(Reaction)


(Filtration)

Reactor

(Stirring at 25°C to 30°C)

Reactor

(Heat at 45°C to 50°C for 1 h)

Dimethylformamide 9.1 kg

Potassium Carbonate 0.55 kg

LOT- Ester 0.91 kg

Chloroiodomethane 1.53 kg

Purified water 29 kg

Pet ether 6.4 kg

Purified water 12 kg

Pet ether recovery

5.2 kg + residue

0.8kg

Aq. Effluent

50.7 kg Acetone 22 kg

Reactor

(Distillation)

Reactor

(Cool at 25°C to 30°C)

Reactor

(Stir at 0°C to 5°C)


(Filtration)

TD/VTD

(Drying)

Acetone recovery

17.6 kg

Residue 0.6 kg

Loteprednol Etabonate 0.978 kg

Reactor

(Distillation)

Mole Balance:

INPUTNo. of

molesMol.Wt. OUTPUT

No. of

molesMol. Wt.

Amfenac sodium 1 277 Nepafenac 1 254

Methyl iodide 1 141 Sodium Iodide 1 149

Ammonia 1 17 Methanol 1 32


Material Balance:

Kg OUTPUT Kg

Amfenac Sodium = 1.000 Product

Dimethylformamide = 8.000 Wt of product = 0.420

Methyl Iodide = 2.000 Recovery

Liq. Ammonia (27%) = 18.000 Dimethyl formamide = 6.00

Pet Ether = 12.500 Pet Ether = 10.625

Isopropyl alcohol = 13.000 Pet ether loss 1.875

Activated charcoal = 0.247 Isopropyl alcohol = 12.00

Hyflo super cel = 0.700 Isopropyl alcohol loss = 1.00

Water = 6.000

Aqueous for effluent = 25.50

Organic Residue

Organic Residue = 1.655


Inorganic Solid Waste = 2.375

Total Input 61.45 Total Output = 61.45

(Hyflo super cel+NaI and Activated Charcoal)

INPUT

Product Name : Nepafenac

CAS No. 78281-72-8

Stage: Preparation of Nepafenac

Aqueous

(Water+Liq. Ammonia and DMF traces)

O NH2

ONa

O

O NH2

NH2

O

Amfenac Sodium

Nepafenac

+ CH3I

Methyl iodide

NH3

Ammonia

+

+

(M.Wt.-277) (141) (17)

M.Wt.-254

NaI +

Sodium Iodide

CH3OH

Methanol

(149) (32)

Stage-I


Product Name : Nepafenac

Description :

Initially, DMF was taken in the reactor and added Amfenac sodium, cooled to 10°C to 15°C and

added Methyl iodide, reaction mass maintained for 60 to 90 min. Cooled reaction mass to 0°C to

5°C and added ammonia again maintained reaction mass for 12 h. Separated solid filtered through

centrifuge. Isolated product purified in water followed by Pet ether leaching and IPA crystallization

yields pure Nepafenac.

Product Name: Nepafenac

CAS No.: 78281-72-8


Reactor

(Charging)

Reactor

(Stirring)

Cooling

Reactor

(Stirring)

Reactor

(Addition)

Reactor

(Stirring)

Reactor

(Addition)

Reactor

(Stirring)

Reactor

(Addition)

Reactor

(Addition)

Cooling

N,N-Dimethyl formamide 8 kg

Amfenac Sodium 1 kg

Methyl Iodide 2 kg

Ammonia solution 6 kg



Reactor

(Stirring)

Raise temp

Nutsche

(Filtration)

Filtrate

Reactor

(Quenching)

Reactor

(Stirring)

Centrifuge

(Filtration)

Wet cake

Reactor

(Charging)

Heating

Reactor

(Stirring for 50-60 min)

Centrifuge

(Filtration)

TD/VTD

(Drying)

Reactor

(Charging)

Heating

MLR for recovery

DMF 7.8 kg recovery

Aq. MLR for ETP 23.5 kg

Water 3 kg

Water 3 kg

Pet Ether 10 kg

Pet Ether 2.5 kg MLR for recovery

Pet ether 10.6 kg recovery

Organic residue 0.86 kg

Isopropyl alcohol 7 kg

Reactor

(Stirring)

Reactor

(Charging)

Reactor


Cooling

Nutsche

(Hyflo Filtration)

Reactor


Centrifuge

(Filtration)

TD/VTD (Drying)

Activated charcoal 0.247

kg

Isopropyl alcohol 3 kg Inorganic waste 2.375

kg

Isopropyl alcohol 3 kg MLR for recovery

IPA 12 kg recovery


Nepafenac 0.420 kg

Mole Balance:

INPUTNo. of


No. of

molesMol. Wt.

PAL-Benzisoquinolinone 1 294.39 PAL-Base 1 296.41

H2 1 2

Purified Water = 296.4 Total Output = 296.4

Material Balance:

Kg OUTPUT Kg

PAL-Benzisoquinolinone = 1.00 Product

Ammonium Formate = 2.00 PAL-Base = 0.90

Pd/C(10%) = 0.10 Recovery

Acetic Acid = 0.20 Recovered Ethyl Acetate = 2.50

Perchloric Acid = 0.68 Ethyl Acetate loss = 0.50

Liq. Ammonia (30% sol) = 0.20 Aqueous

Ethyl Acetate = 3.00 Water Effluent = 12.98


Organic Residue

Recovered Pd/C = 0.10


Product Name: Palonosetron Hydrochloride

INPUT

CAS No.: 135729-62-3

Stage-1: Preparation of PAL-Base


(Water + Acetic acid + Perchloric acid + water from liq.

ammonia)

N

ON

N

ON

H

PAL-BasePAL-Benzisoquinolinone

+ Pd/C

(M. Wt.: 294.39) (296.41)

H2

Hydrogen Gas

(2)

Stage-1

++ Pd/C

Mole Balance:

INPUTNo. of


No. of

molesMol. Wt.

PAL-Base 1 296.5 Palonosetron Hydrochloride 1 332.9

Hydrochloric acid 1 36.4


Material Balance:

Kg OUTPUT Kg

PAL-Base = 0.90 Product

Ethanolic HCl = 8.10 Palonosetron Hydrochloride = 0.95

Isopropyl Alcohol = 4.00 Recovery

Recovery of mixed solvent = 11.00

Mixed solvent loss = 1.00

Organic Residue



Stage-2: Preparation of Palonosetron Hydrochloride

INPUT

To the solution of Ethanolic HCl and Palonosetron base (PAL-Base) was added at 0°C to 5°C and stirred for 15

min. The filtered product was stirred using isopropyl alcohol as solvent at 25°C to 30°C to give the required

hydrochloride salt.

Reaction mixture of PAL-Benzisoquinolinone, Ammonium formate, Acetic acid, Perchloric acid and Pd/C heated to

85°C to 90°C for 24h. Catalyst was filtered at room temperature. Filtrate was concentrated at 80°C to 85°C and then

water was added. pH was adjusted using Ammonium hydroxide at RT and extracted by ethyl acetate. The organic

layer was concentrated under vacuum at 45°C to 50°C. The product was filtered using water to get PAL-Base.


Description:



N

ON

H

N

ON

H.HCl

Palonosetron HClPAL-Base

Ethanolic HCl+

(M.Wt.: 296.5) ( 332.87)

Hydrochloric Acid

Stage-2

(36.4)


CAS No.: 135729-62-3


PAL-Benziisoquinolinone

1.0 kg

Ammonium Formate 2.0 kg

Acetic Acid 0.20 kg

Perchloric Acid 0.68 kg

Pd/C 10% 0.10 kg

Water 2.0 kg Pd/C for Decompose

0.10 kg

Water waste

2.3 kg

Water 5.8 kg

Ammonium Hydroxide

Solution 0.20kg

Ethyl acetate 3.0 kg Water Effluent

8.68 kg


Recovery

Reactor


30°C)

Reactor


90°C for 24 h)

Centrifuge/Nutsche

Filter

Reactor


to 85°C)

Reactor

(Cooling)

Reactor

(pH adjustment)

Reactor

(Extraction and layer

separation)

Reactor

(Distillation)

Water 2.0 kg Water Effluent

2.0 kg

PAL-Base 0.9 kg


PAL-Base 0.9 kg

Ethanolic HCl 8.0 kg

Isopropyl Alcohol 4.0 kg

TD/VTD

(Drying)

Reactor

(Reaction Charging)

Reactor


5°C)

Centrifuge/Nutsche

Filter

(Filtration)

Reactor


55°C)

Reactor

(Cooling)

Reactor

(Cooling)

Centrifuge/Nutsche

Filter

Mixed solvent recovery

11 kg

Residue 0.05 kg

Palonosetron Hydrochloride 0.95 kg

Reactor

(Chilling at 0°C to 5°C)

Centrifuge/Nutsche

Filter

(Filtration)

TD/VTD

(Drying)

Reactor

(Distillation)

CAS No.: 52-21-1

Stage: Preparation of Prednisolone Acetate


Mole Balance:

INPUTNo. of


No. of

molesMol. Wt.

Prednisolone 1 360.44 Prednisolone Acetate 1 402.48

Acetic anhydride 1 102.09 Acetic acid 1 60.05


Material Balance:

Kg OUTPUT Kg

Product

Prednisolone Acetate = 0.80

Recovery

Acetic anhydride = 3.41

DMSO = 4.0 Aqueous = 44.287

Triethyl amine = 5.63 Effluent

DMAP = 0.033

Conc. Hydrochloric acid = 18.11

Acetone = 12.05

5 % NaHCO3 solution = 0.854


(Acetic Anhydride + Triethyl Amine + DMSO +

Aq. HCl + Sodium Chloride + NaHCO3 + Water )

Prednisolone, DMSO, DMAP, Triethyl amine charged in reactor at 25°C to 30°C.Cooled reaction mass to 10°C

to 15°C then added Acetic anhydride dropwise in reaction mass. Maintained reaction mass at 10°C to 15°C for

1 h, after completion of reaction mass was quenched by chilled aq. HCl. Product isolated by filtration and

washed with water.


Description :

INPUT

Prednisolone = 1.0

Product Name :Prednisolone Acetate

HO

OH

O

OH

O

H

HH

HO

OH

O

O

O

H

HH

O

(CH3CO)2O+

Prednisolone Acetic anhydride Prednisolon Acetate

(M.wt.: 402.48)(102.09)(M.wt.: 360.44)

+

O

OH

Acetic acid

(60.05)

Product Name: Prednisolone Acetate

CAS No.: 52-21-1


DMSO 4.0 kg

Prednisolone 1.0 kg

Triethylamine 5.63 kg

DMAP 0.033 kg

Acetic anhydride 3.41kg

Water

Dil. HCl solution 18.11 kg

Aq. waste for ETP

31.287 kg

Aq. 5% NaHCO3 0.854 kg Aq. waste for ETP

Acetone 12.05 kg washing 13 kg

Prednisolone acetate

0.8 kg

Reactor


30°C)

Reactor

(Cool to 10°C to

15°C)

Reactor

(Maintaining at

10°C to 15°C

) Reactor

(Reaction mas at

10°C to 15°C)

Centrifuge/Nutsche

(Filtration)

Wet cake

TD/VTD

Drying

Mole Balance:

INPUTNo. of


No. of

molesMol. Wt.

Pleuromutilin-22-tosylate 1 533 Retapamulin 1 518

Triethyl amine 1 101 Triethyl amine 1 101

Tropine-3-thiol hydrochloride 1 194 Hydrochloric acid 1 36

P-Toluene Sulphonic acid 1 172


Material Balance:

Kg OUTPUT Kg

Product

Pleuromutilin-22-tosylate = 1.0 Retapamulin = 0.91

Triethyl amine = 0.7 Recovery

Tropine-3-thiol hydrochloride = 0.4 MIBK = 1.70

Water = 4.58 MIBK Evaporation Loss = 0.20

Conc.HCl = 0.37 Aqueous

Sodium Hydroxide = 0.02 Effluent = 5.53

MIBK = 2.0

Organic residue = 0.51

Water loss during processing = 0.25


Product Name : Retapamulin

CAS No. 224452-66-8

( Water + NaOH + HCl + Organic and Inorganic

mass)

stage: Preparation of Retapamulin

INPUT

O

O

HO

OS

O

O

O

O

OH

HO

SO

NCH3

Pleuromutilin-22-tosylate Tropine-3-thiol hydrochloride

Retapamulin

(M.Wt : 532.69) (193.74)

C8H16ClNS + C6H15N

Triethyl amine

(101.19)

(M.Wt :517.76)

+ C6H15N

Triethyl amine

(101.19)

+ ClH

Hydrochloric acid

(36.46)

C7H8O3S+

P-Toluene sulphonic acid

(172.2)

Stage-I

Initially, charged Isobutyl methyl ketone, tropin-3-thiol hydrochloride. Stirred and added Triethylamine

followed by pleuromutilin-22-tosylate at 25°C to 30°C. Reaction mass heated to 48°c to 50°C and maintained

for 12 hrs. After completion of reaction added water adjust pH with HCl solution. Stir, settle and separate.

Water was charged to organic layer and adjust pH. Stirred, settled, separated and adjusted pH of aqueous

layer with sodium hydroxide. Separated solid filtered through centrifuge. Purified crude Retapamulin in water

to get pure Retapamulin.

Product Name : Retapamulin

Description :

stage: Preparation of Retapamulin

Product Name: Retapamulin

CAS No.: 224452-66-8

Stage: Preparation of Retapamulin

MIBK 2 kg

Tropin-3-thiol

Hydrochloride 0.4 kg

Triethyl amine 0.701 kg

Pleuromutilin-22-

Tosylate 1 kg

Water 1 kg

HCl 0.12 kg

Aq. Effluent

1.93 kg

Water 1 kg

HCl 0.25 kg

MIBK 1.7 kg recovery

Organic Layer for recovery


4N Sodium Hydroxide

Solution 0.100 kg

(0.016 kg NaOH +

0.084 kg water)

Aq. MLR for ETP

1.30 kg

Water 2 kg

Reactor

(Reaction)

Reactor

(pH adjustment)

Reactor

(Layer separation)

Reactor

(Organic layer)

Reactor

(pH adjustment)

Centrifuge

(Filtration)

Reactor

(Crude Retapamulin)

Reactor

(pH adjustment)

Reactor

(Layer separation)

Water 0.5 kg Aq. MLR for ETP

2.30 kg

Retapamulin 0.91 kg

Reactor

(Heating and Stirring)

Centrifuge/Nutsche

(Filter and wash)

TD/VTD

(Drying)

CAS No.: NA

Stage : Preparation of Sildenafil Citrate Mask complex


Mole Balance: Product is resin based, Mole balance is not estimated

INPUTNo. of


No. of

molesMol. Wt.

Sildenafil Citrate IH/IP 1 Sildenafil Citrate IC-MK 1

Mask IC-MK-9014

(white) III 1 Water 1 18

Purified Water 1 18

Total Input = NA Total Output = NA

Material Balance: Product is resin based, Material balance is not estimated

Kg OUTPUT Kg

Product

Sildenafil Citrate IC-MK = 1.5

Aqueous

Mask IC-MK-9014

(white) III = 1.0 Effluent = 4.5

Purified Water = 4.0 (Water + Organic Residue)

Total Input = 6.0

Description :

Product Name : Sildenafil Citrate Mask complex

Product Name : Sildenafil Citrate Mask complex

Sildenafil Citrate and Mask IC-MK-9014 were stirred in purified water for 2 hours at 30-40 °C and filtered to give

Sildenafil Citrate Mask Complex.


Total Output = 6.0

INPUT

Sildenafil Citrate IH / IP = 1.0

Mask IC-MK-9014 1kg

Sildenafil Citrate Sildenafil Citrate IC-MK-9014 Complex (1:1)

Product Name: Sildenafil Citrate Mask Complex

CAS No.: NA

Stage: Preparation of Sildenafil Citrate Mask Complex

Mask Complex 1.0 kg


Sildenafil Citrate 1.0 kg

Aq. Waste 3.0 kg

Water wash 1.0 kg

Aq. Waste 1.0 kg


Sildenafil citrate Mask Complex

1.5 kg

Reactor

(Reaction)

Reactor

(Reaction)

Reactor

(Stir for 2 h)

Centrifuge/Nutsche

Filter

Reactor

(Wet cake)

Centrifuge/Nutsche

Filter

TD/VTD

(Drying)

CAS No. 57333-96-7

Mole Balance:

INPUTNo. of


No. of

molesMol. Wt.

(TAC-TBDMS ) 1 677 Tacalcitol Monohydrate 1 435

Methane Sulphonic acid 1 96 tert-butyl dimethyl silyloxide 1 279

Water 2 36 Methane Sulphonic acid 1 96


Material Balance:

Kg OUTPUT Kg

Product

Stage-1 = 0.5

Recovery

Methane Sulphonic acid = 1.1 Methanol = 3.6

Water = 4.0 Methanol loss = 0.40

Methanol = 4.0 Acetone = 2.70

Sodium bicarbonate solution = 2.5 Acetone loss = 0.3

Acetone = 3

Aqueous

Effluent = 8.0

Organic Residue

Organic residue after distillation = 0.14


Product Name: Tacalcitol Monohydrate

Stage : Preparation of Tacalcitol Monohydrate

INPUT

Bis(tert-butyldimethylsilyloxy)-

1a-24(R)-

dihydroxycholecalciferol D3

(TAC-TBDMS )

= 1.0

(Water + tert-butyl dimethyl silyloxide + Sodium salt

of Methane Sulphonic acid + Sodium Bicarbonate

solution)


Description :

Stage : Preparation of Tacalcitol Monohydrate

H2C

HO

HO

OH

H

Tacalcitol MH

H2O

Stage-I

OHO

HO

OSi

O

Si

H

bis(tert-butyldimethylsilyloxy)-1a-24(R)-dihydroxycholecalciferol D3 (TAC-TBDMS )

(M.Wt : 677.16)

Methane Sulphonic acid

+ CH4O3S

(96.11)

+ H2O

Water

(36)

(M.Wt : 434.65)

+ C12H30O3Si2

(278.54)

tert-butyl dimethyl silyloxide

+

2

CH4O3S

Methane Sulphonic acid

(96.11)

Charge methanol and the Bis(tert-butyldimethylsilyloxy)-1a-24(R)-dihydroxycholecalciferol D3. Stirred at 25°C

to 30°C for 15 min. Cooled the RM and charged methane Sulphonic acid. stirred the RM with water and

Aq.NaHCO3 solution. Solids are formed. The solid was isolated via filtration. the wet cake was purified in

mixture of Acetone and water to give Tacalcitol monohydrate.


CAS No.: 57333-96-7

Stage: Preparation of Tacalcitol Monohydrate

TAC-TBDMS 1.0 kg

Methanol 4.0 kg

Methane Sulphonic acid 1.1 kg

Water 4.0 kg Aq. NaHCO3 2.5 kg

Waste Water 4.0 kg

Acetone 3.0 kg


Waste Water 4.0 kg

Tacalcitol Monohydrate

0.5 kg

Reactor

(Reaction)

(Reactor)

(Addition at 0 °C to

5 °C)

Reactor (Quenching)


Reactor (Wet cake)

Reactor (Stirring at 0 °C-5 °C)

Reactor (Reaction Mass)


TD/VTD (Drying)

CAS No.: 906093-29-6

Stage-1: Preparation of TEN Crude


Mole Balance:

INPUTNo. of


No. of

molesMol. Wt.

TEN Acid 1 455.55 TEN Crude 1 628.86

Dicyclohexyl carbodiimide 1 206.33 Dicyclohexyl urea 1 224.34

Thiazolidine 1 89.15 tert. Butyl hydrogen carbonate 1 118.13

Hydro bromic acid 2.5 202.28

Purified water 1 18.02


Material Balance:

Kg OUTPUT Kg

Product

TEN Acid = 1.0 TEN Crude = 1.1

Dicyclohexyl carbodiimide = 0.55 RecoveryThiazolidine = 0.25 Ethyl acetate recovery = 11.66HOBt = 0.378 Ethyl acetate loss = 1.34

Dimethyl Formamide = 5.0 Isopropyl Alcohol recovery = 11.72

6% Aq. acetic acid solution = 3.0 Isopropyl Alcohol loss = 1.30

3.5 % Aq. Sodium bicarbonate

solution= 6.0 =

Ethyl acetate = 13.0 Aqueous

Purified water = 15.0 Effluent = 33.038

10% Brine solution = 3.0

Isopropyl Alcohol = 12.28

48% HBr = 1.08

= 0.38



Organic Residue after solvent recovery

Product Name: Teneligliptin Hydrobromide Hydrate

INPUT

( DMF+ Water + Sodium bicarbonate + Sodium chloride + Dicyclohexyl

urea)

N

N

OH

O

N

NNPh

N

N

O

N

NN

Ph

N S+

HN

S

O O

OO

TEN Acid Thiazolidine Boc protected Teneligliptin

+ NC

N

Dicyclohexyl carbodiimide

+

(M.wt :455.55) (89.15) (206.33)

HNC

NHO

(526.69)

(224.34)

Dicyclohexyl Urea

NH

N

O

N

NN

Ph

N S

2.5 HBrnH2O

(M.wt.: 628.86)

TEN Crude

OO

HO

(118.13)

tert-butyl hydrogen carbonate

2.5HBr

(202.28)

H2O

(18.02)

Stage-2: Preparation of Teneligliptin Hydrobromide Hydrate

Mole Balance:

INPUTNo. of


No. of

molesMol. Wt.

TEN crude 1 628.86Teneligliptin Hydrobromide

Hydrate1 628.86


Material Balance:

Kg OUTPUT Kg

Product

TEN crude = 1.1 Teneligliptin Hydrobromide Hydrate = 1

Purified Water = 0.11 Recovery

Ethanol = 8.8 Ethanol Recovery = 8.225

Ethanol loss = 0.575

Organic Residue after solvent recovery

= 0.21



TEN acid, DMF, HoBt, DCC taken in reactor at 25°C tom 30°C. Cooled reaction mass to 15°C tom 20°C to which Thiazolidine solution

in DMF added slowly in reaction mass then raised temperature to 25°C tom 30°C and maintain till complies. Charged ethyl acetate

and water in reaction mass and filtered insoluble materials and washed with ethyl acetate, the clear filtrate separated ethyl acetate

layer and aq. layer extracted with ethyl acetate. All extracted ethyl acetate layers combined together and washed serially with purified

water, 6 % Acetic acid solution, purified water, 3.5 % sodium bicarbonate solution then brine solution. Finally ethyl acetate layer

distilled out completely under vacuum then added isopropyl alcohol in residue to get slurry. Heated reaction mass at 70°C tom 75°C

to get clear solution, gradually cooled to 40°C tom 45°C, filtered and washed with isopropyl alcohol to get solid dried at 50°C tom

55°C.

TEN crude and ethanol taken in a reactor at 25°C tom 30°C. Heated reaction mass at 70°C tom 75°C to get clear solution to which

added purified water then cooled to 30°C tom 35°C and filtered solid and washed with ethanol to get solid, dried solid at 55°C to

60°C to get Teneligliptin Hydrobromide Hydrate.


Description :



INPUT

NH

N

O

N

NN

Ph

N S

2.5 HBrnH2O

(M.wt.: 628.86)

TEN Crude

NH

N

O

N

NN

Ph

N S

2.5 HBrnH2O

TEN

(M.wt.: 628.86)


CAS No.: 906093-29-6

Stage-1: Preparation of Teneligliptin Crude

TEN Acid 1.0 kg

Dicyclohexyl

carbodiimide 0.55 kg

Dimethyl formamide 4.5kg

HOBt 0.378 kg

Thiozolidine 0.25 kg

in DMF 0.5 kg

Ethyl Acetate 13 kg

Purified water 9 kg 14.498 kg aqueous layer for ETP

Purified water 3 kg

6 % Acetic acid 3 kg 18.54 kg Aqueous layer for ETP

Purified water 3 kg

3.5 % NaHCO3 wash 6 kg

10% brine wash 3 kg

11.66 kg Ethyl acetate recovery

Isopropyl Alcohol 10 kg

48 % HBr 1.08 kg

Isopropyl Alcohol 2.28 kg Isopropyl Alcohol ML

Isopropyl Alcohol recovery

Teneligliptin Crude 11.72 kg

1.1 kg

Reactor


30°C)

Reactor


20°C)

Reactor

(Reaction mass at

25°C to 30°C)

Reactor

(Washing to Ethyl

acetate layer)

Reactor

(Distillation)

Reactor

(Reaction mass at

70°C to 75°C)

)

Centrifuge/Nutsche


45°C)


TEN Crude 1.1 kg

Ethanol 6.6 kg


Ethanol washing 2.2 kg Ethanol ML

8.225 kg Recovery

Teneligliptin Hydrobromide Hydrate

1.0 kg

Reactor

(Charging at 25°C

to 30°C)

Reactor (Reaction

mass clear at 70°C

to 75°C)

Centrifuge/Nutsche


30°C)

)

TD/VTD

Drying

Sr. No Category Name of Product

New Product or

existing Product in

MPCB consent

RM NamesRequirement of Raw

Material (MT/M)

Characteristics of Raw

Material (Hazardous/

Non-Hazardous)

Flammability of

Material

(Flammable & Non-

flammable)

One-time storage

within plant (MT)Mode of Storage & Transport

Amfenac Sodium 2.381 Hazardous Non- Flammable 0.4762 HDPE carbouy( By Road)

Dimethylformamide 19.048 Hazardous Non- Flammable 3.8096 HDPE carbouy( By Road)

Methyl Iodide 4.762 Hazardous Non- Flammable 0.9524 HDPE carbouy( By Road)

Liq. Ammonia (27%) 42.857 Hazardous Non- Flammable 8.5714 HDPE carbouy( By Road)

1 Pet Ether 29.762 Hazardous Flammable 5.9524 HDPE carbouy( By Road)

Isopropyl alcohol 30.952 Hazardous Flammable 6.1904 200 Lit MS Drum by road

Activated charcoal 0.588 Non Hazardous Non- Flammable 0.1176 HDPE carbouy( By Road)

Hyflo super cel 1.667 Non Hazardous Non- Flammable 0.3334 HDPE carbouy( By Road)

Water 14.286 Non Hazardous Non- Flammable 2.8572 In Tank ( Transport NA)

LOT-KSM 1.022 Hazardous Flammable 0.2044 HDPE carbouy( By Road)

Dichloromethane 3.579 Hazardous Flammable 0.7158 HDPE carbouy( By Road)

Pyridine 0.583 Hazardous Flammable 0.1166 HDPE carbouy( By Road)

4-Dimethyl amino pyridine 0.020 Hazardous Flammable 0.004 HDPE carbouy( By Road)

Ethyl Chloroformate 0.348 Hazardous Non- Flammable 0.0696 HDPE carbouy( By Road)

Aq. HCl solution 22.802 Hazardous Non- Flammable 4.5604 HDPE carbouy( By Road)

Pet-ether 23.926 Hazardous Flammable 4.7852 HDPE carbouy( By Road)

Ethyl acetate 3.067 Hazardous Flammable 0.6134 HDPE carbouy( By Road)

Potassium carbonate 0.562 Hazardous Non- Flammable 0.1124 HDPE carbouy( By Road)

Dimethylformamide 9.305 Hazardous Flammable 1.861 HDPE carbouy( By Road)

Chloroiodomethane 1.564 Hazardous Non- Flammable 0.3128 HDPE carbouy( By Road)

Acetone 22.495 Hazardous Flammable 4.499 HDPE carbouy( By Road)


7-(4-Bromobenzoyl)-1,3-

dihydro-2H-indole-2-one 1.550

Hazardous Non- Flammable0.31

HDPE carbouy( By Road)

Sodium Hydroxide 0.357 Hazardous Non- Flammable 0.0714 HDPE carbouy( By Road)

Toluene 19.555 Hazardous Flammable 3.911 HDPE carbouy( By Road)

Ethanol 5.930 Hazardous Flammable 1.186 HDPE carbouy( By Road)

Isopropyl Ether 11.240 Hazardous Flammable 2.248 HDPE carbouy( By Road)


1,2-dimethoxy ethane 6.169 Hazardous Non- Flammable 1.2338 HDPE drum / Poly bag ( By road)

Prednisolone 1.250 Hazardous Non- Flammable 0.25 HDPE drum / Poly bag ( By road)

Acetic anhydride 4.263 Hazardous Non- Flammable 0.8526 HDPE drum / Poly bag ( By road)

DMSO 5.000 Hazardous Flammable 1 HDPE drum / Poly bag ( By road)

Triethyl amine 7.038 Hazardous Flammable 1.4076 HDPE drum / Poly bag ( By road)

DMAP 0.041 Hazardous Non- Flammable 0.0082 HDPE drum / Poly bag ( By road)

Conc. Hydrochloric acid 22.638 Hazardous Non- Flammable 4.5276 HDPE drum / Poly bag ( By road)

Acetone 15.063 Hazardous Flammable 3.0126 HDPE drum / Poly bag ( By road)

5 % NaHCO3 solution 1.068 Non- Flammable 0.2136 HDPE drum / Poly bag ( By road)

Bromfenac

SodiumAnti -inflammatory

Loteprednol

EtabonateAnti -inflammatory

Existing Product

Existing Product

Existing Product

Existing ProductNepafenacAnti -inflammatory

Prednisolone

AcetateAnti -inflammatory

2

3

4

ANNEXURE -4

(5Z)-7-((1R,2R,3R,5S)-2-((E)-

3,3-difluoro

-4-phenoxybut-1-enyl)-3,5-

dihydroxycyclopentyl)

hept-5-enoic acid

(Tafluprost acid)

1.429

Hazardous Non- Flammable

0.2858

HDPE drum / Poly bag ( By road)

Isopropyl iodide 1.429 Hazardous Non- Flammable 0.2858 HDPE drum / Poly bag ( By road)

Dimethyl Formamide 0.714 Hazardous Flammable 0.1428 HDPE drum / Poly bag ( By road)

Cesium carbonate 0.429 Hazardous Non- Flammable 0.0858 HDPE drum / Poly bag ( By road)

Diethyl ether 2.143 Hazardous Non- Flammable 0.4286 HDPE drum / Poly bag ( By road)


N-[4-(2-formylaminoacetyl)-5-

hydroxy-2-phenoxy phenyl

methane sulphonamide1.111


0.2222


N,N-Dimethylformamide

Dimethylacetal0.889



Hydrochloric acid 0.511 Hazardous Non- Flammable 0.1022 HDPE drum / Poly bag ( By road)



Desonide 1.667 Hazardous Non- Flammable 0.3334 HDPE drum / Poly bag ( By road)

Pyrophosphoryl chloride 1.250 Hazardous Non- Flammable 0.25 HDPE drum / Poly bag ( By road)

Tetrahydrofuran 8.333 Hazardous Non- Flammable 1.6666 HDPE drum / Poly bag ( By road)

Ethyl acetate 6.667 Hazardous Flammable 1.3334 HDPE drum / Poly bag ( By road)


Sodium hydroxide 1.375 Hazardous Non- Flammable 0.275 HDPE drum / Poly bag ( By road)

Methanol 8.333 Hazardous Flammable 1.6666 HDPE drum / Poly bag ( By road)

Ethanol 1.667 Hazardous Flammable 0.3334 HDPE drum / Poly bag ( By road)

(S)-1-(4-(2-(cyclopropyl-

methoxy)ethyl)phenoxy)-3-

(isopropyl amino)propan-2-

ol(Levobetaxolol free base)

1.429


0.2858


Ethyl Acetate 7.143 Hazardous Flammable 1.4286 HDPE drum / Poly bag ( By road)

IPA.HCl 0.243 Hazardous Non- Flammable 0.0486 HDPE drum / Poly bag ( By road)

4-(4-bromo-3-

formylphenoxy) benzonitrile1.667



Chloro(methoxy)methane 0.443 Hazardous Non- Flammable 0.0886 HDPE drum / Poly bag ( By road)

Trimethyl borate 0.572 Hazardous Non- Flammable 0.1144 HDPE drum / Poly bag ( By road)

Water 5.000 Non Hazardous Non- Flammable 1 In Tank ( Transport NA)


Racemic amine 1.667 Hazardous Non- Flammable 0.3334 HDPE drum / Poly bag ( By road)

N-acetyl-L-leucine 1.050 Hazardous Non- Flammable 0.21 HDPE drum / Poly bag ( By road)


3-acetamide Phthalic

anhydride0.500 Hazardous Non- Flammable 0.1 HDPE drum / Poly bag ( By road)

Glacial acetic acid 3.500 Hazardous Non- Flammable 0.7 HDPE drum / Poly bag ( By road)


Dichloromethane 6.667 Hazardous Flammable 1.3334 HDPE drum / Poly bag ( By road)

Sodium carbonate 0.250 Hazardous Non- Flammable 0.05 HDPE drum / Poly bag ( By road)


IguratimodAnti -inflammatory

TafluprostAnti -inflammatory

Anti -inflammatory Crisaborole

Levobetaxolol HClAnti -inflammatory

Existing Product

Existing Product

Existing Product

Existing Product

Existing Product

Anti -inflammatory Apremilast

Desonide 21 -

PhosphateAnti -inflammatory

New Product

5

6

7

8

10

9


Methyl 2-(4-(3-(3-

fluorophenyl)

-4,5-dihydro-5,5-dimethyl-4-

oxofuran-2-yl)phenyl

sulfonyl)

1.667


0.3334


Sodium Hydroxide 0.165 Hazardous Non- Flammable 0.033 HDPE drum / Poly bag ( By road)



Aq. Ammonia 0.077 Hazardous Non- Flammable 0.0154 HDPE drum / Poly bag ( By road)

Isopropyl Alcohol 3.333 Flammable 0.6666 HDPE drum / Poly bag ( By road)

(2S,3R,4S,5R)-5-(6-Amino-9H-

purin-9-yl)-tetrahydro-3,4-

dihydroxy-N-methylfuran-2-

carboxamide

0.833


0.1666


1-(Bromomethyl)-3-

iodobenzene0.917



Methylene Chloride 5.000 Hazardous Non- Flammable 1 HDPE drum / Poly bag ( By road)

Potassium Iodide 0.042 Hazardous Non- Flammable 0.0084 HDPE drum / Poly bag ( By road)



6a , 9-Difluoro-11b,17,21-

trihydroxypregna-1,4-die

3,20-dione 17-butyrate (KSM)

1.053Hazardous Non- Flammable

0.2106HDPE drum / Poly bag ( By road)

Pyridine 0.316 Hazardous Flammable 0.0632 HDPE drum / Poly bag ( By road)

Acetyl Chloride 0.211 Hazardous Non- Flammable 0.0422 HDPE drum / Poly bag ( By road)

DMF 0.421 Hazardous Flammable 0.0842 HDPE drum / Poly bag ( By road)


Isopropyl Ether 5.263 Flammable 1.0526 HDPE drum / Poly bag ( By road)

Activated Charcoal 0.211 Non Hazardous Non- Flammable 0.0422 HDPE drum / Poly bag ( By road)

Hyflo 0.211 Non Hazardous Non- Flammable 0.0422 HDPE drum / Poly bag ( By road)


(2S)-Benzyl-2-[5,7-Dichloro-

1,2,3,4-tetrahydro-

isoquinoline-6-carbonyl)-

amino]-3-(3-methanesulfonyl-

phenyl)-propionate

2.000


0.4


6-Benzofuran carboxylic acid0.540



Phosgene 0.330 Hazardous Non- Flammable 0.066 HDPE drum / Poly bag ( By road)

N,N-Diisopropyl ethyl amine0.432




Hydrogen 0.006 Hazardous Flammable 0.0012 Cylinder ( By Road)

MDC 16.000 Hazardous Non- Flammable 3.2 HDPE drum / Poly bag ( By road)


Palladium on carbon 0.118 Hazardous Non- Flammable 0.0236 HDPE drum / Poly bag ( By road)

Hyflo supercel 0.200 Non Hazardous Non- Flammable 0.04 HDPE drum / Poly bag ( By road)



5-nitrosalicylic acid 2.000 Hazardous Non- Flammable 0.4 HDPE drum / Poly bag ( By road)

10% Raney Nickel 1.400 Hazardous Non- Flammable 0.28 HDPE drum / Poly bag ( By road)

Hyflo 0.500 Non Hazardous Non- Flammable 0.1 HDPE drum / Poly bag ( By road)

Potassium Hydroxide 0.400 Hazardous Non- Flammable 0.08 HDPE drum / Poly bag ( By road)

11

Mesalamine

PolmacoxibAnti -inflammatory

Piclidenoson

Difluprednate

Existing Product

Existing Product

New Product

New Product

Anti -inflammatory

Anti -inflammatory Apremilast

Anti -inflammatory

LifitegrastAnti -inflammatory

Existing Product

New Product

Anti -inflammatory

10

12

13

14

15

Concentrated HCl 4.000 Hazardous Non- Flammable 0.8 HDPE drum / Poly bag ( By road)

Sodium Hydroxide 0.560 Hazardous Non- Flammable 0.112 HDPE drum / Poly bag ( By road)


IPA 10.000 Flammable 2 HDPE drum / Poly bag ( By road)


1-{4-[2-(cyclopropylmethoxy)-

ethoxy]-phenoxy}-2,3-epoxy-

propane



Isopropyl amine 2.000 Hazardous Flammable 0.4 HDPE drum / Poly bag ( By road)

Toluene 5.000 Hazardous Flammable 1 HDPE drum / Poly bag ( By road)


Hydrogen chloride gas 0.330 Hazardous Non- Flammable 0.066 Cylinder ( By Road)

Sucrose 10.000 Hazardous Non- Flammable 2 HDPE drum / Poly bag ( By road)

Methanol 20.000 Hazardous Flammable 4 HDPE drum / Poly bag ( By road)

Dichloromethane 20.000 Hazardous Flammable 4 HDPE drum / Poly bag ( By road)

Corn steep 3.300 Non- Flammable 0.66 HDPE drum / Poly bag ( By road)

Sodium nitrate 1.000 Hazardous Non- Flammable 0.2 HDPE drum / Poly bag ( By road)

Potassium hydrogen

phosphate0.300 Hazardous Non- Flammable 0.06 HDPE drum / Poly bag ( By road)

Magnesium sulfate 0.160 Hazardous Non- Flammable 0.032 HDPE drum / Poly bag ( By road)

Potassium chloride 0.160 Hazardous Non- Flammable 0.032 HDPE drum / Poly bag ( By road)

Ferrous sulfate 0.003 Hazardous Non- Flammable 0.0006 HDPE drum / Poly bag ( By road)


9-Fluoro-11beta, 17, 21-

trihydroxy-16alpha-

methylpregna-1, 4-diene-



Potassium bicarbonate 6.667 Hazardous Non- Flammable 1.3334 HDPE drum / Poly bag ( By road)



6-methyl-17-hydroxy-1,4,9-

triene -pregn-3,20-dione 1.282Hazardous Non- Flammable


PTSA 0.936 Hazardous Non- Flammable 0.1872 HDPE drum / Poly bag ( By road)

Acetic Anhydride 0.641 Hazardous Non- Flammable 0.1282 HDPE drum / Poly bag ( By road)



4-isopropyl-3methyl-1-phenyl-

1H-pyrazol-5(4H)-one 1.136Hazardous Non- Flammable


Dimethyl sulphate 4.545 Hazardous Non- Flammable 0.909 HDPE drum / Poly bag ( By road)



3-Cyclopropyl methoxy-4-

difluoro methoxy benzoic

acid

( ROF-Acid)

0.769


0.1538


Thionyl chloride 0.762 Hazardous Non- Flammable 0.1524 HDPE drum / Poly bag ( By road)

Toluene 3.923 Hazardous Flammable 0.7846 HDPE drum / Poly bag ( By road)

Dimethyl Formamide (DMF) 3.854 Hazardous Flammable 0.7708 HDPE drum / Poly bag ( By road)

( SOL-amine) 0.738 Hazardous Non- Flammable 0.1476 HDPE drum / Poly bag ( By road)



Mesalamine

Propyphenazone

Anti -inflammatory

DexamethasoneAnti -inflammatory

Fluorometholone

acetate

Cyclosporine

Anti -inflammatory

RoflumilastAnti -inflammatory

New Product

Existing Product

New Product

New Product

Existing Product

Anti -inflammatory New Product

Betaxolol HCLAnti -inflammatory

Anti -inflammatory

Existing Product

17

18

19

20

21

15

16

Tetrahydrofuran 3.846 Hazardous Non- Flammable 0.7692 HDPE drum / Poly bag ( By road)

Isopropyl alcohol 3.846 Flammable 0.7692 HDPE drum / Poly bag ( By road)


Fumaric acid 1.111 Hazardous Non- Flammable 0.2222 HDPE drum / Poly bag ( By road)


Sulphuric acid 0.006 Hazardous Non- Flammable 0.0012 HDPE drum / Poly bag ( By road)



9α-fluoro-11β, 16α, 17α, 21-

tetrahydroxy-1, 4-

pregnadiene-3, 20-Dione






Petroleum ether 7.143 Hazardous Flammable 1.4286 HDPE drum / Poly bag ( By road)

Sodium bicarbonate 0.714 Hazardous Non- Flammable 0.1428 HDPE drum / Poly bag ( By road)

Triamcinolone Acetonide 1.186 Hazardous Non- Flammable 0.2372 HDPE drum / Poly bag ( By road)


3,3-Dimethyl butanoyl

chloride0.357 Hazardous Non- Flammable 0.0714 HDPE drum / Poly bag ( By road)

Triethylamine 0.400 Hazardous Flammable 0.08 HDPE drum / Poly bag ( By road)

8S,9R,10S,11S,13S,14R,16R,1

7R)-9-chloro -17-(2-

chloroacetyl)-

7,8,11,12,13,15,16,17

-octahydro-11, 17-dihydroxy-

10,13,16- trimethyl 6H-

cyclopenta phenanthren -3

1.250


0.25


Furan-2-carbonyl chloride 0.875 Hazardous Non- Flammable 0.175 HDPE drum / Poly bag ( By road)




4-(2-hydroxyethoxy)-3,5-

dimethylbenzaldehyde 1.163Hazardous Non- Flammable


2-amino-4,6-

dimethoxybenzamide1.279 Hazardous Non- Flammable 0.2558 HDPE drum / Poly bag ( By road)

p-Toluene sulfonic acid 1.047 Hazardous Non- Flammable 0.2094 HDPE drum / Poly bag ( By road)

Sodium Bisulfite 0.581 Hazardous Non- Flammable 0.1162 HDPE drum / Poly bag ( By road)


Dimethyl acetamide 5.814 Hazardous Flammable 1.1628 HDPE drum / Poly bag ( By road)

N-(2-phenoxyphenyl)methane sulfonamide1.667 Hazardous Non- Flammable 0.3334 HDPE drum / Poly bag ( By road)

Glacial acetic acid 6.667 Hazardous Non- Flammable 1.3334 HDPE drum / Poly bag ( By road)

Nitric acid 0.567 Hazardous Non- Flammable 0.1134 HDPE drum / Poly bag ( By road)

Water 16.667 Non Hazardous Non- Flammable 3.3334 In Tank ( Transport NA)Phenylmethyl 1-(4-

chlorobenzoyl)-

5-methoxy-2-methyl-1H-

indole-3-acetatel

2.500


0.5



Palladium on Charcoal 0.250 Hazardous Non- Flammable 0.05 HDPE drum / Poly bag ( By road)


Potassium o-bromobenzoate 1.429 Hazardous Non- Flammable 0.2858 HDPE drum / Poly bag ( By road)

Anti -inflammatory

RoflumilastAnti -inflammatory

Dimethyl

FumarateAnti -inflammatory

Apabetalone

Triamcinolone

Hexacetonide

Existing Product

New Product

New Product

Anti -inflammatory

Existing Product

New Product

Anti -inflammatory

Mometasone

Furoate

Monohydrate

Existing ProductMeclofenamate SodiumAnti -inflammatory

21

22

23

24

25

28

Anti -inflammatory Nimesulide Existing Product26

Existing ProductIndomethacinAnti -inflammatory27

2,6-dichloro-3-methylaniline 1.043 Hazardous Non- Flammable 0.2086 HDPE drum / Poly bag ( By road)

N-ethylmorpholine 0.757 Hazardous Non- Flammable 0.1514 HDPE drum / Poly bag ( By road)

Diglyme 5.714 Hazardous Non- Flammable 1.1428 HDPE drum / Poly bag ( By road)

Cupric bromide 0.057 Hazardous Non- Flammable 0.0114 HDPE drum / Poly bag ( By road)


NaOH 0.286 Hazardous Non- Flammable 0.0572 HDPE drum / Poly bag ( By road)

Water for NaOH son 2.857 Hazardous Non- Flammable 0.5714 In container


Fenspiride Base 1.250 Hazardous Non- Flammable 0.25 HDPE drum / Poly bag ( By road)

Hydrochloric acid in Ethyl acetate 0.625 Hazardous Non- Flammable 0.125 HDPE drum / Poly bag ( By road)

Ethyl acetate 10.000 Hazardous Flammable 2 HDPE drum / Poly bag ( By road)

1-Chloroacetamido-1,3,3,5,-

pentamethyl cyclohexane1.667

Non Hazardous Non Flammable0.3334


Thiourea 0.717 Hazardous Non Flammable 0.1434 HDPE drum / Poly bag ( By road)

Conc. HCl 2.500 Hazardous Non Flammable 0.5 HDPE drum / Poly bag ( By road)

Water 19.167 Non Hazardous Non Flammable 3.8334 In Tank

Neramexane Hydrochloride 1.317 Hazardous Non Flammable 0.2634 HDPE drum / Poly bag ( By road)

Methane sulfonic acid 0.667 Hazardous Non Flammable 0.1334 HDPE drum / Poly bag ( By road)

Sodium hydroxide 3.333 Hazardous Non Flammable 0.6666 HDPE drum / Poly bag ( By road)


Nalbuphine 1.429 Hazardous Non Flammable 0.2858 HDPE drum / Poly bag ( By road)

Sebacoyl chloride 0.500 Hazardous Non Flammable 0.1 HDPE drum / Poly bag ( By road)



SUF-Piperidylamine 1.163 Hazardous Non Flammable 0.2326 HDPE drum / Poly bag ( By road)

Propionic anhydride 1.047 Hazardous Non Flammable 0.2094 HDPE drum / Poly bag ( By road)

Ammonium hydroxide 1.860 Hazardous Non Flammable 0.372 HDPE drum / Poly bag ( By road)



MTBE 2.326 Hazardous Flammable 0.4652 HDPE drum / Poly bag ( By road)

Citric acid 0.477 Hazardous Non Flammable 0.0954 HDPE drum / Poly bag ( By road)

Isopropyl alcohol 4.070 Hazardous Flammable 0.814 HDPE drum / Poly bag ( By road)

(Z)-7-methyl-6-ninenoic acid 1.667 Hazardous Non Flammable 0.3334 HDPE drum / Poly bag ( By road)


Ethylchloroformate 1.017 Hazardous Non Flammable 0.2034 HDPE drum / Poly bag ( By road)

Vanilamine Hydrochloride 2.667 Hazardous Non Flammable 0.5334 HDPE drum / Poly bag ( By road)

Conc. Hydrochloric Acid 0.633 Hazardous Non Flammable 0.1266 HDPE drum / Poly bag ( By road)

Water 10.000 Non Hazardous Non Flammable 2 In Tank

Sodium bicarbonate 0.250 Hazardous Non Flammable 0.05 HDPE drum / Poly bag ( By road)

Dimethylformamide 3.833 Hazardous Flammable 0.7666 HDPE drum / Poly bag ( By road)

Diisopropyl ether 13.333 Hazardous Flammable 2.6666 HDPE drum / Poly bag ( By road)

n-Hexane 6.667 Hazardous Flammable 1.3334 HDPE drum / Poly bag ( By road)


O-methoxy Phenol 1.020 Hazardous Non Flammable 0.204 HDPE drum / Poly bag ( By road)

NaOH 0.714 Hazardous Non Flammable 0.1428 HDPE drum / Poly bag ( By road)

Analgesic Zucapsaicin Existing Product

Nalbuphine

Sebacate

Analgesic Sufentanil Citrate

New ProductAnalgesic

Existing Product

Anti -inflammatoryFenspiride Chlorhydrate Existing Product

Neramaxane

MesylateAnalgesic

Existing ProductMeclofenamate SodiumAnti -inflammatory

New Product

30

31

32

28

29

Existing ProductAmtolmetin

guacilAnalgesic34

33


Iso-propoxycarbonylamino acetic acid-2-guacil ester3.214 Hazardous Non Flammable 0.6428 HDPE drum / Poly bag ( By road)


Pet Ether 2.041 Hazardous Flammable 0.4082 HDPE drum / Poly bag ( By road)

(S)-4-chlorobutyl 2-(2-methoxynaphthalen-6-yl)propanoate1.111

Hazardous Non Flammable0.2222


Silver Nitrate 0.611 Hazardous Non Flammable 0.1222 HDPE drum / Poly bag ( By road)


Acetonitrile 11.111 Hazardous Flammable 2.2222 HDPE drum / Poly bag ( By road)

8,9-Difluoro-5-methyl-6,7-

dihydro-1-oxo-1H,5H-

benzo[ij]quinolizine-2-

1.183Hazardous Non Flammable


Piperidin-4-ol 0.592 Hazardous Non Flammable 0.1184 HDPE drum / Poly bag ( By road)


(TOF-benzyl protected) 1.316 Hazardous Non Flammable 0.2632 HDPE drum / Poly bag ( By road)

10%Pd/C 0.132 Hazardous Flammable 0.0264 HDPE drum / Poly bag ( By road)

Acetic acid 0.237 Hazardous Flammable 0.0474 HDPE drum / Poly bag ( By road)

IPA 9.211 Hazardous Flammable 1.8422 HDPE drum / Poly bag ( By road)

Hydrogen 0.066 Hazardous Flammable 0.0132 HDPE drum / Poly bag ( By road)

TOF-Debenzyl 1.053 Hazardous Flammable 0.2106 HDPE drum / Poly bag ( By road)

Ethyl 2-Cyanoacetate 0.526 Hazardous Flammable 0.1052 HDPE drum / Poly bag ( By road)





Water 0.526 Hazardous Non Flammable 0.1052 In Tank

(4S)-2-((R)-(2-

phenylacetamido)(carboxy)m

ethyl)-5,5-

dimethylthiazolidine-4-

carboxylic acid mercaptide

6.667

Hazardous Non Flammable

1.3334


Hydrochloric acid 0.800 Hazardous Non Flammable 0.16 HDPE drum / Poly bag ( By road)

Water73.333


In Tank


40% Dimethyl amine 0.700 Hazardous Non Flammable 0.14 HDPE drum / Poly bag ( By road)

4,7-dichloroquinoline0.714



5-(N-Ethyl-N-2-

hydroxyethylamino)-2-pentyl-

amine



Sulfuric acid 0.621 Hazardous 0.1242 HDPE drum / Poly bag ( By road)

Potassium iodide 0.013 Hazardous Flammable 0.0026 HDPE drum / Poly bag ( By road)





(4-(1H-pyrazol-4-yl)-7H-

pyrrolo[2,3-d]pyrimidin-7-

yl)methyl pivalate



Tofacitinib CitrateRheumatoid Arthritis

New Product

New Product

New Product

Existing Product

Hydroxychloroqui

ne Sulphate

PenicillamineRheumatoid Arthritis

BaricitinibRheumatoid Arthritis


Existing ProductNaproxcinod

40

Existing ProductAmtolmetin

guacilAnalgesic34

Existing ProductNadifloxacinAnalgesic36

37

38

39

Analgesic35

2-(I-(ethylsulfonyl)azetidin-3-

ylidene)acetonitrile 0.691Hazardous Non Flammable


1,8-Diazabicyclo[5.4.0]undec-

7-ene0.028 Hazardous Non Flammable 0.0056 HDPE drum / Poly bag ( By road)

Dimethyl formamide 1.111 Hazardous Flammable 0.2222 HDPE drum / Poly bag ( By road)

sodium hydroxide 0.144 Hazardous 0.0288 Container


2-Isopropyl-1,3-dimethoxy-5-

styrylbenzene 2.000Hazardous Non Flammable


Pyridine chloride 4.000 Hazardous Non Flammable 0.8 HDPE drum / Poly bag ( By road)

Water 20.000 Hazardous Non Flammable 4 In Tank



Uridine 5'-diphosphate

disodium salt4.000 Hazardous Flammable 0.8 HDPE drum / Poly bag ( By road)

Bis(triethylammonium)

pyrophosphate(II)3.544 Hazardous Non Flammable 0.7088 HDPE drum / Poly bag ( By road)

Carbonyl Diimidazole 1.168 Hazardous Non Flammable 0.2336 HDPE drum / Poly bag ( By road)


Water 20.000 Hazardous Non Flammable 4 HDPE drum / Poly bag ( By road)

OMI-Boc 1.818 Hazardous Non Flammable 0.3636 HDPE drum / Poly bag ( By road)

4M HCl in Dioxane 2.727 Hazardous Flammable 0.5454 HDPE drum / Poly bag ( By road)

1,4 Dioxane 7.273 Hazardous Flammable 1.4546 HDPE drum / Poly bag ( By road)


Water 1.818 Hazardous Non Flammable 0.3636 HDPE drum / Poly bag ( By road)


3-(3,5-dimethylphenoxy)-l-

amino-2-propanol1.299



Methyl carbamate 0.519 Hazardous Non Flammable 0.1038 HDPE drum / Poly bag ( By road)

Butyl acetate 5.195 Hazardous Flammable 1.039 HDPE drum / Poly bag ( By road)



Ilaprazole Sodium 1.163 Hazardous Non Flammable 0.2326 Container( By Road)

Acetic acid 0.174 Hazardous Flammable 0.0348 Container( By Road)

Water 1.744 Hazardous Non Flammable 0.3488

Ethanol 12.616 Hazardous Flammable 2.5232 Container( By Road)

2-[(R)-[(4-chloro-3-methyl-2-

pyridinyl)methyl]sulfinyl]-1H-

benzimidazole 1.250

Hazardous Non Flammable 0.25 Container( By Road)

2,2,2-trifluoroethanol 0.438 Hazardous Flammable 0.0876 Container( By Road)

Dimethylacetamide 2.500 Hazardous Flammable 0.5 Container( By Road)

Potassium t-Butoxide 2.250

Hazardous Non Flammable 0.45 Container( By Road)

Acetic acid 0.575 Hazardous Flammable 0.115 Container( By Road)

Water 1.750 Hazardous Non Flammable 0.35 Container( By Road)

5-methoxy-2-[((4-methoxy-

3,5-dimethyl-2-pyridinyl)

methyl)-thio)-1H

benzimidazole)

1.333

Hazardous Non Flammable 0.2666 Container( By Road)Proton pump inhibitor

Diquafosol

TetrasodiumOphalmic

Proton pump inhibitor

DexlansoprazoleProton pump inhibitor

Omeprazole

Sodium

MetaxaloneMuscle relaxant

Ilaprazole

New Product

New Product

Existing Product

New Product

New Product

New Product

New Product

Omidenepag Isopropyl Ophalmic New Product


BaricitinibRheumatoid Arthritis

Benvitimod

40

41

42

43

44

45

46

47

Per acetic acid 1.667 Hazardous Flammable 0.3334 Container( By Road)

Ethyl acetate 6.667 Hazardous Flammable 1.3334 Container( By Road)

10% Aq. Sodium hydroxide 5.333 Hazardous Non Flammable 1.0666 Container

LAN-Chloro 1.538 Hazardous Non Flammable 0.3076 Container

Methanol 9.231 Hazardous Flammable 1.8462 Container( By Road)

Sodium Hydroxide 0.508 Hazardous Non Flammable 0.1016 Container( By Road)

LAN-Mercapto 0.892 Hazardous Non Flammable 0.1784 Container( By Road)


Sodium Hydroxide solution 3.077 Hazardous Non Flammable 0.6154 Container

THF 4.846 Hazardous Flammable 0.9692 Container( By Road)

Sodium Hypochlorite solution 11.692 Hazardous Non Flammable 2.3384 Container( By Road)

Sodium Thiosulfate solution 15.385 Hazardous Non Flammable 3.077 Container( By Road)

10 % Acetic Acid solution 18.462 Hazardous Non Flammable 3.6924 Container( By Road)

Ethanol 6.154 Hazardous Flammable 1.2308 Container( By Road)

Acetone 7.692 Hazardous Flammable 1.5384 Container( By Road)

Isopropyl Ether 6.154 Hazardous Flammable 1.2308 Container( By Road)

(TEG-Tosyl ) 2.000 Hazardous Non Flammable 0.4 Container( By Road)

THF 10.000 Hazardous Flammable 2 Container( By Road)


Methanol 8.000 Hazardous Flammable 1.6 Container( By Road)

Sodium Hydroxide 1.200 Hazardous Non Flammable 0.24 Container Sodium Dihydrogen

phosphate1.884 Hazardous Flammable 0.3768 Container( By Road)

Ethyl Acetate 12.000 Hazardous Flammable 2.4 Container( By Road)

Heptane 12.000 Hazardous Flammable 2.4 Container( By Road)

N-{4-[4-(piperidinomethyl)

pyridyl-2oxy]-cis-2-butene}

phthalimide maleate

1.053


0.2106

Container( By Road)

p-nitro phenyl 2-

(furfurylsulfinyl) acetate0.505


Container( By Road)

Ethyl acetate 5.263 Hazardous Flammable 1.0526 Container( By Road)


p-nitrophenyl 2-

(furfurylsulfinyl) acetate0.337



REB-Amino acid 1.000 Hazardous Non Flammable 0.2 HDPE drum / Poly bag ( By road)

4-chlorobenzoyl chloride 0.473 Hazardous Non Flammable 0.0946 HDPE drum / Poly bag ( By road)

Potassium Carbonate 0.373 Hazardous Non Flammable 0.0746 HDPE drum / Poly bag ( By road)



Acetone 5.000 Hazardous Flammable 1 Container( By Road)

Resin supported Linaclotide 2.500 Hazardous Non Flammable 0.5 HDPE drum / Poly bag ( By road)

1% TFA in MDC 15.800 Hazardous Non Flammable 3.16 HDPE drum / Poly bag ( By road)

10% DIPEA in MDC 5.300 Hazardous Non Flammable 1.06 HDPE drum / Poly bag ( By road)

80% TFA in MDC 19.800 Hazardous Non Flammable 3.96 HDPE drum / Poly bag ( By road)

5% TIS 0.980 Hazardous Non Flammable 0.196 HDPE drum / Poly bag ( By road)

10% H2O2 7.500 Hazardous Non Flammable 1.5 HDPE drum / Poly bag ( By road)

Proton pump inhibitorOmeprazole

Sodium

Lansoprazole

Sodium

RebamipideGastritis

LinaclotideIrritable bowel

syndrome (IBS)

New Product

New Product

Existing Product

New ProductTegoprazan

51

52

Existing ProductProton pump inhibitor

Proton pump inhibitor49

48

Existing ProductProton pump inhibitor50

47

Lafutidine

5% DTT 0.985 Hazardous Non Flammable 0.197 HDPE drum / Poly bag ( By road)

MTBE 25.000 Hazardous Flammable 5 Container( By Road)

t-Butyl Elobixibat 2.174 Hazardous Non Flammable 0.4348 HDPE drum / Poly bag ( By road)

Hydrochloric Acid 0.693 Hazardous Non Flammable 0.1386 HDPE drum / Poly bag ( By road)

Sodium Hydroxide 0.230 Hazardous Non Flammable 0.046 HDPE drum / Poly bag ( By road)

Water 10.870 Hazardous Non Flammable 2.174 In Tanker

Glycerin 0.588 Hazardous Non Flammable 0.1176 HDPE drum / Poly bag ( By road)

Nitric acid 1.206 Hazardous Non Flammable 0.2412 HDPE drum / Poly bag ( By road)

Sulphuric acid 0.629 Hazardous Non Flammable 0.1258 HDPE drum / Poly bag ( By road)

Dichloromethane 2.941 Hazardous Flammable 0.5882 Container( By Road)


N,N-dimethyl-2(11-oxo-6,11-

dihydrobenz[b,e]oxepin-2-

yl)acetamide3.704


0.7408


Dimethylaminopropyl

magnesium chloride1.815



Tetrahydrofuran 14.815 Hazardous Flammable 2.963 HDPE drum / Poly bag ( By road)

Hydrochloric acid (35%) 0.370 Hazardous Non Flammable 0.074 HDPE drum / Poly bag ( By road)



HCl gas 0.452 Hazardous Non Flammable 0.0904 Cylinder ( By Road)


Charcoal 0.074 Hazardous Non Flammable 0.0148 HDPE drum / Poly bag ( By road)

Hyflo 0.259 Hazardous Non Flammable 0.0518 HDPE drum / Poly bag ( By road)

Protected Bilastine 2.000 Hazardous Non Flammable 0.4 HDPE drum / Poly bag ( By road)

3 N Hydrochloric acid 20.000 Hazardous Non Flammable 4 HDPE drum / Poly bag ( By road)

50% Sodium hydroxide soln 20.000 Hazardous Non Flammable 4 HDPE drum / Poly bag ( By road)

n- Butanol 10.400 Hazardous Flammable 2.08 HDPE drum / Poly bag ( By road)


Water 20.000 Hazardous Non Flammable 4 In Tanker

(S)-4-(4-chlorophenyl)-2-

pyridyl methoxy piperidine 1.250



Ethyl-4-bromobutyrate 1.046 Hazardous 0.2092 HDPE drum / Poly bag ( By road)


Potassium carbonate (powder) 0.855 Hazardous Non Flammable 0.171 HDPE drum / Poly bag ( By road)

Potassium iodide 0.006 Hazardous Non Flammable 0.0012 HDPE drum / Poly bag ( By road)

Conc. Hydrochloric acid 0.446 Hazardous Non Flammable 0.0892 HDPE drum / Poly bag ( By road)

Isopropyl ether 9.063 Hazardous Flammable 1.8126 HDPE drum / Poly bag ( By road)

Sodium hydroxide flakes 0.496 Hazardous Non Flammable 0.0992 HDPE drum / Poly bag ( By road)




Sodium sulphate 1.250 Hazardous Non Flammable 0.25 HDPE drum / Poly bag ( By road)


57

Linaclotide

NitroglycerinAcute prophylaxis of

angina pectoris

Bepotastine

BesilateAntihistamine , Antiallergic

Irritable bowel

syndrome (IBS)

Irritable bowel

syndrome (IBS) Elobixibat

Olopatadine HCLAntihistamine , Antiallergic

New Product

New Product

Existing Product

Antihistamine , Antiallergic Bilastine Existing Product

Existing Product

New Product

52

54

55

56

53

Benzene Sulfonic acid 0.575 Hazardous Non Flammable 0.115 HDPE drum / Poly bag ( By road)



Activated charcoal 0.056 Hazardous Non Flammable 0.0112 HDPE drum / Poly bag ( By road)

Hyflo supercel 0.375 Hazardous Non Flammable 0.075 HDPE drum / Poly bag ( By road)

Bis(tert-

butyldimethylsilyloxy)-1a-

24(R)-



Methane Sulphonic acid 2.200 Hazardous Non Flammable 0.44 HDPE drum / Poly bag ( By road)



Sodium bicarbonate solution 5.000 Hazardous Non Flammable 1 HDPE drum / Poly bag ( By road)


PAL-Benzisoquinolinone 1.053 Hazardous Non Flammable 0.2106 HDPE drum / Poly bag ( By road)

Ammonium Formate 2.105 Hazardous Non Flammable 0.421 HDPE drum / Poly bag ( By road)

Pd/C(10%) 0.105 Hazardous Flammable 0.021 HDPE drum / Poly bag ( By road)

Acetic Acid 0.211 Hazardous Flammable 0.0422 HDPE drum / Poly bag ( By road)

Perchloric Acid 0.716 Hazardous Non Flammable 0.1432 HDPE drum / Poly bag ( By road)

Liq.Ammonia(30% sol) 0.211 Hazardous Non Flammable 0.0422 HDPE drum / Poly bag ( By road)


Purified Water 10.316 Hazardous Non Flammable 2.0632 In Tanker

Ethanolic HCl 8.526 Hazardous Flammable 1.7052 HDPE drum / Poly bag ( By road)

Isopropyl Alcohol 4.211 Hazardous Flammable 0.8422 HDPE drum / Poly bag ( By road)

Flupritine 1.053 Hazardous Non Flammable 0.2106 HDPE drum / Poly bag ( By road)

Maleic Acid 0.632 Hazardous Non Flammable 0.1264 HDPE drum / Poly bag ( By road)


Cetyl Chloro Formate 0.556 Hazardous Non Flammable 0.1112 HDPE drum / Poly bag ( By road)

Amino methyl benzoic acid 0.444 Hazardous Non Flammable 0.0888 HDPE drum / Poly bag ( By road)


NaHCO3 0.046 Hazardous Non Flammable 0.0092 HDPE drum / Poly bag ( By road)



Fexapotide without Leucine 1.429 Hazardous Non Flammable 0.2858 HDPE drum / Poly bag ( By road)

L-Leucine 0.097 Hazardous Non Flammable 0.0194 HDPE drum / Poly bag ( By road)


5-((R)-2-(2-(2-(2, 2, 2-

trifluoroethoxy) phenoxy)

ethylamino) propyl)-1-(3-

hydroxypropyl) indoline-7-

carbonitrile

1.429

Hazardous Non Flammable 0.2858 HDPE drum / Poly bag ( By road)





Purified water 10.714 Hazardous Non Flammable 2.1428 In Tanke

(R)-2-(4-

nitrophenethylamino)-1-

phenylethanol

1.190Hazardous Non Flammable 0.238 HDPE drum / Poly bag ( By road)

Fexapotide

57

58

Bepotastine

BesilateAntihistamine , Antiallergic

Benign prostatic hyperplasia

CetilistatObesity

Palonosetron HCLAntihistamine ,

Antiallergic

SilodosinBenign prostatic hyperplasia

MirabegronBenign prostatic hyperplasia New Product

New Product

New Product

Existing Product

Existing Product

Existing Product

Existing ProductTacalcitol MHAntihistamine ,

Antiallergic

59

61

62

63

64

Existing ProductFlupirtine

maleate

Antihistamine ,

Antiallergic60


5% Pd/C 0.119 Hazardous Flammable 0.0238 HDPE drum / Poly bag ( By road)



2-(2-aminothiazol-4-yl)acetic

acid0.705 Hazardous Non Flammable 0.141 HDPE drum / Poly bag ( By road)


water 5.952 Hazardous Non Flammable 1.1904 In Tanke

Diethylenetriamine 1.111 Hazardous Non Flammable 0.2222 HDPE drum / Poly bag ( By road)

Epichlorohydrin 1.878 Hazardous Flammable 0.3756 HDPE drum / Poly bag ( By road)


Witconate60B 0.022 Hazardous Non Flammable 0.0044 HDPE drum / Poly bag ( By road)



4-amino-2-methyl-10H-

thieno[2,3-b][1,5]

benzodiazepine,

hydrochloride

0.952


0.1904


N-methyl Piperazine 3.314 Hazardous Non Flammable 0.6628 HDPE drum / Poly bag ( By road)


Dimethyl sulfoxide 4.429 Hazardous Flammable 0.8858 HDPE drum / Poly bag ( By road)



Triethyl Amine 0.362 Hazardous Flammable 0.0724 HDPE drum / Poly bag ( By road)

rOP-pyruvate 1.000 Hazardous Non Flammable 0.2 HDPE drum / Poly bag ( By road)

1-(2,3-

dichlorophenylpiperazine 0.942



Sodium Carbonate 0.533 Hazardous Non Flammable 0.1066 HDPE drum / Poly bag ( By road)



ROP-pyruvate 1.563 Hazardous Non Flammable 0.3126 HDPE drum / Poly bag ( By road)

sodium hydroxide 0.494 Hazardous Non Flammable 0.0988 HDPE drum / Poly bag ( By road)

Hydrogen peroxide(50 %) 0.247 Hazardous Non Flammable 0.0494 HDPE drum / Poly bag ( By road)


sodium bisulphite 0.781 Hazardous Non Flammable 0.1562 HDPE drum / Poly bag ( By road)

water 3.125 Hazardous Non Flammable 0.625 In Tank

Palladium on carbon 0.109 Hazardous Flammable 0.0218 HDPE drum / Poly bag ( By road)




Hydrogen Gas 0.156 Hazardous Flammable 0.0312 In Cylinder ( By Road)

Latanoprost acid 1.250 Hazardous Non Flammable 0.25 HDPE drum / Poly bag ( By road)

Isopropyl Iodide 2.675 Hazardous Non Flammable 0.535 HDPE drum / Poly bag ( By road)

1,8-Diazabicyclo [5.4.0] undec-7-ene 2.813 Hazardous Non Flammable 0.5626 HDPE drum / Poly bag ( By road)

Acetone Commercial 11.250 Hazardous Flammable 2.25 HDPE drum / Poly bag ( By road)

66

67

Ropinirol HClParkinson's Disease68

MirabegronBenign prostatic hyperplasia

Antiglaucoma

Chronic diarrhea Colestipol HCL

AripiprazoleAntipsychotic

OlanzapineAntipsychotic

Latanoprost

New Product

Existing Product

Existing Product

Existing Product

New Product

New Product

64

65

69

Dichloromethane Commercial 25.000 Hazardous Flammable 5 HDPE drum / Poly bag ( By road)

3% Aqueous citric acid

solution30.000 Hazardous Non Flammable 6 HDPE drum / Poly bag ( By road)

5% Sodium bicarbonate

Solution15.000 Hazardous Non Flammable 3 HDPE drum / Poly bag ( By road)

BRI-Tosyl 2.000 Hazardous Non Flammable 0.4 HDPE drum / Poly bag ( By road)

Ethyl amine (70%) 2.000 Hazardous Non Flammable 0.4 HDPE drum / Poly bag ( By road)




Liquid Ammonia 0.700 Hazardous Non Flammable 0.14 HDPE drum / Poly bag ( By road)


N-(diaminomethylidene)-2-

fluoro-4-(2-methyl

cyclopentyl)-3-methyl

sulfonyl benzamide

1.429




LIM-Protected 2.000 Hazardous Non Flammable 0.4 HDPE drum / Poly bag ( By road)


CuCl2.2H2O 0.062 Hazardous Non Flammable 0.0124 HDPE drum / Poly bag ( By road)


NET-KSM-I 1.163 Hazardous Non Flammable 0.2326 HDPE drum / Poly bag ( By road)

2,5-Dimethyl benzoyl chloride 0.558 Hazardous Non Flammable 0.1116 HDPE drum / Poly bag ( By road)





NET-Boc 1.291 Hazardous Non Flammable 0.2582 HDPE drum / Poly bag ( By road)


Dioxane 6.105 Hazardous Flammable 1.221 HDPE drum / Poly bag ( By road)


Latanoprost acid 1.111 Hazardous Non Flammable 0.2222 HDPE drum / Poly bag ( By road)

4-Bromobutylnitrate 0.564 Hazardous 0.1128 HDPE drum / Poly bag ( By road)


Potassium iodide 0.056 Hazardous Non Flammable 0.0112 HDPE drum / Poly bag ( By road)

TRA-Acid 2.000 Hazardous Non Flammable 0.4 HDPE drum / Poly bag ( By road)

2-Iodopropane 5.000 Hazardous Flammable 1 HDPE drum / Poly bag ( By road)

Sodium carbonate 1.000 Hazardous Non Flammable 0.2 HDPE drum / Poly bag ( By road)

Acetone 10.000 Hazardous Flammable 2 HDPE drum / Poly bag ( By road)

Water 10.000 Hazardous Non Flammable 2 In Tanker

5- bromo-N-(1-acetyl-4,5 -dihydro-imidazole-2-yl)-6 -quinoxaline1.299 Hazardous Non Flammable 0.2598 HDPE drum / Poly bag ( By road)



Tartaric acid 0.636 Hazardous Non Flammable 0.1272 HDPE drum / Poly bag ( By road)


TAV-BOC 1.250 Hazardous Non Flammable 0.25 HDPE drum / Poly bag ( By road)

Trifluoroacetic acid 0.425 Hazardous Non Flammable 0.085 HDPE drum / Poly bag ( By road)



Antiglaucoma

BrinzolamideAntiglaucoma

Latanoprost

Ripasudil

Hydrochloride

Hydrate

Antiglaucoma

TavilermideGlaucoma

LimaprostAntiglaucoma

Netarsudil Glaucoma

Brimonidine

TartrateGlaucoma

Latanoprostene

BunodGlaucoma

TravoprostGlaucoma

Existing Product

New Product

Existing Product

New Product

New Product

New Product

New Product

New Product

New Product

69

70

71

72

73

77

74

75

76



BIM-Ester 1.429 Hazardous Non Flammable 0.2858 HDPE drum / Poly bag ( By road)

40% Ethylamine Solution 7.143 Hazardous Non Flammable 1.4286 HDPE drum / Poly bag ( By road)

Di-isopropyl ether 14.286 Hazardous Flammable 2.8572 HDPE drum / Poly bag ( By road)





Cortexolone 17α,21-Dipropionate 1.613 Hazardous Non Flammable 0.3226 HDPE drum / Poly bag ( By road)

CCL enzyme 0.403 Hazardous Non Flammable 0.0806 HDPE drum / Poly bag ( By road)



4-((R)-2-(6-(2-(2,6-

dichlorobenzyloxy)ethoxy)

hexylamino)-1-hydroxyethyl)-

2-(hydroxymethyl)phenol

1.429


0.2858


2,2,2-triphenylacetic acid 0.652 Hazardous Non Flammable 0.1304 HDPE drum / Poly bag ( By road)

Ethanol 10.000 Hazardous Flammable 2 HDPE drum / Poly bag ( By road)

ROL-Dehydroether 1.538 Hazardous Non Flammable 0.3076 HDPE drum / Poly bag ( By road)


Aq. NaOH 1.538 Hazardous Non Flammable 0.3076 HDPE drum / Poly bag ( By road)

H2 0.154 Hazardous Flammable 0.0308 Cylinder ( By Road)

Pd/C 0.038 Hazardous Flammable 0.0076 HDPE drum / Poly bag ( By road)

7,8,9,10-tetrahydro-8-

trifluoroacetyl-6,10-methano-

6H-pyrazino[2,3-h] [3]

benzazepine

2.500


0.5


Toluene 10.000 Hazardous Flammable 2 HDPE drum / Poly bag ( By road)



Activated Charcoal 0.250 Hazardous Non Flammable 0.05 HDPE drum / Poly bag ( By road)

L-Tartaric acid 1.338 Hazardous Non Flammable 0.2676 HDPE drum / Poly bag ( By road)


11β-[N,N-dimethylamino)-

phenyl]-17α-hydroxy-19-

norpregna-4,9-dine-3,20-

dione

2.000


0.4


Acetic anhydride 2.000 Hazardous Flammable 0.4 HDPE drum / Poly bag ( By road)

P-toluene Sulphonic acid 0.800 Hazardous Non Flammable 0.16 HDPE drum / Poly bag ( By road)



Potassium carbonate 15.000 Hazardous Non Flammable 3 HDPE drum / Poly bag ( By road)

TavilermideGlaucoma

Glaucoma

GlycerolHumectant

Cortexolone 17a-

PropionateAndrogen receptor

Bimatoprost

Vilanterol

trifenatate

beta2-adrenergic

agonist

RolapitantNK1 receptor

antagonist

Varenicline

TartrateReceptor antagonist

Ulipristal AcetateSelective

progesterone

Existing Product

New Product

New Product

Existing Product

New Product

New Product

New Product

New Product

77

78

79

80

81

82

83

84






DAB-Etexilate 1.111 Hazardous Non Flammable 0.2222 HDPE drum / Poly bag ( By road)


Methane Sulphonic Acid 0.167 Hazardous Non Flammable 0.0334 HDPE drum / Poly bag ( By road)

4-(4-((S)-5-(amino methyl)-2-

oxooxazolidin-3-yl) phenyl)

morpholin-3-one

hydrochloride

1.667



5-chlorothiophene-2-

carbonyl chloride 3.683Hazardous Non Flammable 0.7366 HDPE drum / Poly bag ( By road)





EDO-BOC 1.471 Hazardous Non Flammable 0.2942 HDPE drum / Poly bag ( By road)


Methane sulfonic acid (MSA) 1.029 Hazardous Non Flammable 0.2058 HDPE drum / Poly bag ( By road)

Triethyl amine (TEA) 0.368 Hazardous Flammable 0.0736 HDPE drum / Poly bag ( By road)

1-Hydroxybenztriazole (1-HBT) 0.441 Hazardous Non Flammable 0.0882 HDPE drum / Poly bag ( By road)


EDO-Carboxylic acid 0.735 Hazardous Non Flammable 0.147 HDPE drum / Poly bag ( By road)

2-amino-5-methoxy-N-(5-

methylpyridin-2-

yl)benzamide


4-cyanobenzoyl chloride 1.131 Hazardous Non Flammable 0.2262 HDPE drum / Poly bag ( By road)


MDC 17.241 Hazardous Flammable 3.4482 HDPE drum / Poly bag ( By road)


Dimethyl amine 0.268 Hazardous Non Flammable 0.0536 HDPE drum / Poly bag ( By road)




Xylan 1.250 Hazardous Flammable 0.25 HDPE drum / Poly bag ( By road)

Chlorosulphonic acid 4.375 Hazardous Non Flammable 0.875 HDPE drum / Poly bag ( By road)




Hydrogen peroxide 0.625 Hazardous Non Flammable 0.125 HDPE drum / Poly bag ( By road)

ELI-Thiophene sulfide 1.389 Hazardous Non Flammable 0.2778 HDPE drum / Poly bag ( By road)

Meta-chloroperoxybenzoic

acid0.972 Hazardous Flammable 0.1944 HDPE drum / Poly bag ( By road)



Rivaroxaban

BetrixabanAnticoagulant

Pentosan

Polysulfate

Sodium

Dabigatran

Etexilate

Mesylate

Anticoagulant

Ulipristal AcetateSelective

progesterone

Edoxaban

Anticoagulant

Anticoagulant

Anticoagulant

New Product

New Product

New Product

Existing Product

Existing Product

New Product

Anticoagulant New ProductElinogrel

84

85

86

87

88

89

90

Valproic acid 1.333 Hazardous Non Flammable 0.2666 HDPE drum / Poly bag ( By road)



7-Ketolithocholic acid 1.449 Hazardous Non Flammable 0.2898 HDPE drum / Poly bag ( By road)


Pd/C 5 % 0.072 Hazardous Flammable 0.0144 HDPE drum / Poly bag ( By road)

t-Butanol 11.232 Hazardous Flammable 2.2464 HDPE drum / Poly bag ( By road)

Raltegravir 1.316 Hazardous Non Flammable 0.2632 HDPE drum / Poly bag ( By road)



KOH 0.237 Hazardous Non Flammable 0.0474 HDPE drum / Poly bag ( By road)

MAR-Aldehyde 0.833 Hazardous Non Flammable 0.1666 HDPE drum / Poly bag ( By road)

MAR-Triazole 1.000 Hazardous Non Flammable 0.2 HDPE drum / Poly bag ( By road)

Sodium triacetoxy

borohydride0.725 Hazardous Non Flammable 0.145 HDPE drum / Poly bag ( By road)




DAC-Amine 0.833 Hazardous Non Flammable 0.1666 HDPE drum / Poly bag ( By road)

N-methoxycarbonyl-l-valine 1.000 Hazardous Non Flammable 0.2 HDPE drum / Poly bag ( By road)






2-(2-Amino-1, 6-dihydro-6-

oxo-purin-9-yl) methoxy-3-

hydroxy-1-propanyl-N-

(benzyloxycarbonyl)-L-

2.222


Pd (OH)2/C 0.222 Hazardous Flammable 0.0444 HDPE drum / Poly bag ( By road)


H2 gas 0.016 Hazardous Flammable 0.0032 Cylinder ( By Road)



Ester Compound 1.923 Hazardous Non Flammable 0.3846 HDPE drum / Poly bag ( By road)

THF-MeOH Mix(1:1) 9.615 Hazardous Flammable 1.923 Container



1 N HCl 2.308 Hazardous Non Flammable 0.4616 Container

(Z)-4-(4-(2-

(benzyloxy)ethoxy)phenyl)-3,

4-diphenylbut-3-en-1-ol1.818


0.3636


Palladium on carbon 0.009 Hazardous Flammable 0.0018 HDPE drum / Poly bag ( By road)




Daclatasvir

Dihydrochloride

Ursodiol

Anticonvulsant

Antiviral

Antiviral

New ProductDivalproex Sodium

New Product

Existing Product

Antiviral

Antiviral

New ProductValganciclovir

MaravirocAntiviral

Antibiotic

Simeprevir Antiviral

New Product

New Product

New Product

Ospemifene

New ProductRaltegravir

Potassium

91

92

93

94

95

96

97

98



5-(((bezyloxy)-

carbonyl)amino)-1-

cyclopropyl-7-(2,6-dimethyl-4-

pyridyl)-8-methyl-4-oxo-1,4-

dihydro-3-quinolinecarboxylic

1.587


0.3174




11-N-(4-Azido-butyl)-6-O-

methyl-5-desosaminyl-3-oxo-

2-fluro-erythronolide A,



3-Ethynyl-phenylamine 0.397 Hazardous Non Flammable 0.0794 HDPE drum / Poly bag ( By road)

Cu I 0.073 Hazardous Non Flammable 0.0146 HDPE drum / Poly bag ( By road)



Erythromycin Thiocynate 1.429 Hazardous Non Flammable 0.2858 HDPE drum / Poly bag ( By road)


Ethyl Succinyl Chloride 0.586 Hazardous Non Flammable 0.1172 HDPE drum / Poly bag ( By road)




Moxifloxacin base 1.282 Hazardous Non Flammable 0.2564 HDPE drum / Poly bag ( By road)




EDTA disodium salt 0.001 Hazardous Non Flammable 0.0002 HDPE drum / Poly bag ( By road)

4”, 6”-o-cyclohexylidene- 3-

deoxy-1, 3, 2’, 6’, 3”-penta-

amino kanamycin 1.220


0.244



Phosphorous Oxychloride 0.244 Hazardous Non Flammable 0.0488 HDPE drum / Poly bag ( By road)


7-Chloro-1-cyclopropyl-6-

fluoro-1,4-dihydro-4-oxo-1,8-

naphthyridine-3-carboxylic

acid

0.833


0.1666


Pyrolidine compound 0.422 Hazardous Non Flammable 0.0844 HDPE drum / Poly bag ( By road)

3,4,6,7,8,9,10-

octahydropyrimido[1,2-

a]azepine



Dimethyl sulphoxide 2.500 Hazardous Flammable 0.5 HDPE drum / Poly bag ( By road)

Methane sulfonic Acid 0.750 Hazardous Non Flammable 0.15 HDPE drum / Poly bag ( By road)


7- Amino tetracycline 1.020 Hazardous Non Flammable 0.204 HDPE drum / Poly bag ( By road)


1 N HCl 3.974 Hazardous Non Flammable 0.7948 HDPE drum / Poly bag ( By road)

37% Formalin 0.796 Hazardous Non Flammable 0.1592 HDPE drum / Poly bag ( By road)

10% Pd/C 0.397 Hazardous Non Flammable 0.0794 HDPE drum / Poly bag ( By road)

Hyflow 0.194 Hazardous Non Flammable 0.0388 HDPE drum / Poly bag ( By road)


Antibiotic

Ozenoxacin

SolithromycinAntibiotic

Antibiotic

Existing ProductGemifloxacin

MesylateAntibiotic

New ProductTobramycinAntibiotic

Erythromycin

Ethyl SuccinateAntibiotic

New ProductAntibiotic

101

New ProductMoxifloxacin HCL

New Product

New Product

New ProductOspemifene

Antibiotic Minocycline HCL Existing Product

98

99

100

102

103

104

105


1-Cyclopropyl-6-fluoro-7-(3-

(R)-Amino-hexahydro-1H-1.333 Hazardous Non Flammable 0.2666 HDPE drum / Poly bag ( By road)

Sulfuryl Chloride 0.756 Hazardous Non Flammable 0.1512 HDPE drum / Poly bag ( By road)



Purified Water 18.667 Hazardous Non Flammable 3.7334 HDPE drum / Poly bag ( By road)

Rifamycin O 1.429 Hazardous Non Flammable 0.2858 HDPE drum / Poly bag ( By road)

2-amino-4-methyl pyridine 0.614 Hazardous Non Flammable 0.1228 HDPE drum / Poly bag ( By road)

Ascorbic acid 0.043 Hazardous Non Flammable 0.0086 HDPE drum / Poly bag ( By road)




Methacycline hydrochloride 1.408 Hazardous Non Flammable 0.2816 HDPE drum / Poly bag ( By road)


Rhodium Catalyst 0.014 Hazardous Flammable 0.0028 HDPE drum / Poly bag ( By road)

Ethanol HCl 0.001 Hazardous Flammable 0.0002 HDPE drum / Poly bag ( By road)




Methacycline hydrochloride 1.429 Hazardous Non Flammable 0.2858 HDPE drum / Poly bag ( By road)


Rhodium Catalyst/H2 0.014 Hazardous Flammable 0.0028 HDPE drum / Poly bag ( By road)



Pleuromutilin-22-tosylate 1.099 Hazardous Non Flammable 0.2198 HDPE drum / Poly bag ( By road)


Tropine-3-thiol hydrochloride 0.440 Hazardous Non Flammable 0.088 HDPE drum / Poly bag ( By road)


Conc.HCl 0.407 Hazardous Non Flammable 0.0814 HDPE drum / Poly bag ( By road)


MIBK 2.198 Hazardous Flammable 0.4396 HDPE drum / Poly bag ( By road)

Levofloxacin carboxylic acid 1.429 Hazardous Non Flammable 0.2858 HDPE drum / Poly bag ( By road)

N-Methyl Piperazine 1.200 Hazardous Non Flammable 0.24 HDPE drum / Poly bag ( By road)

DMSO 0.714 Hazardous Flammable 0.1428 HDPE drum / Poly bag ( By road)


5 % Aq. Ethanol 18.571 Hazardous Non Flammable 3.7142 HDPE drum / Poly bag ( By road)


7-formylsancycline TFA salt 1.667 Hazardous Non Flammable 0.3334 HDPE drum / Poly bag ( By road)

N,O-dimethyl hydroxylamine

hydrochloride0.583



N,N-dimethyl acetamide 0.417 Hazardous Non Flammable 0.0834 HDPE drum / Poly bag ( By road)

Sodium Cyano borohydride 0.500 Hazardous Non Flammable 0.1 HDPE drum / Poly bag ( By road)

Diethyl ether 4.167 Hazardous Flammable 0.8334 HDPE drum / Poly bag ( By road)

Dichlomethane 5.000 Hazardous Flammable 1 HDPE drum / Poly bag ( By road)


Doxycycline

MonohydrateAntibiotic

New Product

Sarecycline New ProductAntibiotic

Levofloxacin

HemihydrateAntibiotic

New Product

Existing ProductRetapamulinAntibiotic

Existing Product

New Product

Doxycycline

Hyclate

Antibiotic Minocycline HCL Existing Product

Antibiotic

New ProductRifaximinAntibiotic

Besifloxacin HCLAntibiotic

105

106

107

108

109

110

111

112

1-Cyclopropyl-7-fluoro-8-

methoxy-4-oxo-1,4-dihydro-

quinoline-3-carboxylic acid1.429


0.2858


Tert-butyl (3S,5S)-5-

methylpiperidine-3-

ylcarbanmate









Flucloxacillin 1.429 Hazardous Non Flammable 0.2858 HDPE drum / Poly bag ( By road)




9-(amino methyl)minocycline 1.250 Hazardous Non Flammable 0.25 HDPE drum / Poly bag ( By road)

sodium triacetoxy borohydride 1.094 Hazardous Non Flammable 0.2188 HDPE drum / Poly bag ( By road)

Trimethylacetaldehyde 0.281 Hazardous Non Flammable 0.0562 HDPE drum / Poly bag ( By road)



Indium trichloride 0.563 Hazardous Non Flammable 0.1126 HDPE drum / Poly bag ( By road)


Trihydroxy-carboxamide 1.333 Hazardous Non Flammable 0.2666 HDPE drum / Poly bag ( By road)





Diethyl ether 3.333 Hazardous Flammable 0.6666 HDPE drum / Poly bag ( By road)

sodium triacetoxy borohydride 0.027 Hazardous Non Flammable 0.0054 HDPE drum / Poly bag ( By road)

Trimethylacetaldehyde 0.200 Hazardous Non Flammable 0.04 HDPE drum / Poly bag ( By road)



Indium trichloride 0.048 Hazardous Non Flammable 0.0096 HDPE drum / Poly bag ( By road)

FIN-quinoline carboxylic acid 0.800 Hazardous Non Flammable 0.16 HDPE drum / Poly bag ( By road)

FIN-pyrrolidine 0.334 Hazardous Non Flammable 0.0668 HDPE drum / Poly bag ( By road)







3-hydroxyerythromycin 1.429 Hazardous Non Flammable 0.2858 HDPE drum / Poly bag ( By road)

N-Chloro succinamide 0.257 Hazardous Non Flammable 0.0514 HDPE drum / Poly bag ( By road)

Dimethyl sulphide 0.114 Hazardous Non Flammable 0.0228 HDPE drum / Poly bag ( By road)


TEA 0.200 Hazardous Flammable 0.04 HDPE drum / Poly bag ( By road)


Amadacycline

New ProductOmadacyclineAntibiotic

Flucloxacillin

Sodium

New Product

New Product

Antibiotic

New ProductAntibiotic

Antibiotic

Cethromycin

Finafloxacin Antibiotic New Product

New ProductNemonoxacin

116

114

115

117

113

Antibiotic118


CET-Carbonyl compound 1.429 Hazardous Non Flammable 0.2858 HDPE drum / Poly bag ( By road)




L-carnosine 4.400 Hazardous Non Flammable 0.88 HDPE drum / Poly bag ( By road)

Hyaluronic acid 1.333 Hazardous Non Flammable 0.2666 HDPE drum / Poly bag ( By road)

Sodium hydride 0.107 Hazardous Non Flammable 0.0214 HDPE drum / Poly bag ( By road)

THF 6.667 Hazardous Flammable 1.3334 HDPE drum / Poly bag ( By road)


Acetyl chloride 0.567 Hazardous Flammable 0.1134 HDPE drum / Poly bag ( By road)



1-(4-Amino-

benzenemethanesulfonyl)pyr

rolidine hydrochloride 1.333


0.2666

In Tank

Conc. hydrochloric acid 6.293 Hazardous Non Flammable 1.2586 HDPE drum / Poly bag ( By road)

Sodium nitrite 0.560 Hazardous Non Flammable 0.112 HDPE drum / Poly bag ( By road)

Sodium sulfite 4.173 Hazardous Non Flammable 0.8346 HDPE drum / Poly bag ( By road)


N,N-dimethylamino-

butyraldehyde dimethyl

11.560 Hazardous Non Flammable 2.312 HDPE drum / Poly bag ( By road)





3-(2-Hydroxyethyl)-N-methyl-

1-H-indole-5-1.667



Thionyl Chloride 0.833 Hazardous Non Flammable 0.1666 HDPE drum / Poly bag ( By road)


HCl 0.067 Hazardous Non Flammable 0.0134 HDPE drum / Poly bag ( By road)



Dimethylamine 59.000 Hazardous Non Flammable 11.8 HDPE drum / Poly bag ( By road)

Frovatriptan 1.053 Hazardous Non Flammable 0.2106 HDPE drum / Poly bag ( By road)

Succinic acid 0.368 Hazardous Non Flammable 0.0736 HDPE drum / Poly bag ( By road)


2(6-Amino-pyridin-2-yl)-

(1-methyl-piperi-4-yl)-

ethanone



2,4,6-trifluorobenzoylchloride 1.187 Hazardous Non Flammable 0.2374 HDPE drum / Poly bag ( By road)






3-(((R)-1-methylpyrrolidin-2-

yl)methyl)-5-(2-(phenyl

sulfonyl)ethyl)-1H-indole

1.176


0.2352


New Product

New Product

Lasmiditan

MigraineFrovatriptan

SuccinateNew Product

Migraine

Migraine

New ProductEletriptan HBr

Cethromycin

New ProductMigraine

Almotriptan

Sumatriptan

Migraine New Product121

122

123

124

125

Existing ProductN-acetyl-L-

carnosineAntibiotic120

Antibiotic118

Sodium

hyaluronateExisting ProductAntibiotic119

Hydrobromic Acid 0.249 Hazardous Non Flammable 0.0498 HDPE drum / Poly bag ( By road)



(S)-4-(4-hydrazinobenzyl)-1,3-

oxazolidin-2-one

hydrochloride



4-dimethylamino butanal

diethylacetal1.267 Hazardous Non Flammable 0.2534 HDPE drum / Poly bag ( By road)



Aq. Ammonia 3.200 Hazardous Non Flammable 0.64 HDPE drum / Poly bag ( By road)


RIM-Azide 1.563 Hazardous Non Flammable 0.3126 HDPE drum / Poly bag ( By road)



Trimethylphosphin 5.156 Hazardous Non Flammable 1.0312 HDPE drum / Poly bag ( By road)


Sevelamer Hydrochloride 1.111 Hazardous Non Flammable 0.2222 HDPE drum / Poly bag ( By road)



(R)-quinuclidin-3-yl 2-hydroxy-

2,2-di(thiophen-2-yl)acetate0.769



Chloroform 1.538 Hazardous Flammable 0.3076 HDPE drum / Poly bag ( By road)


3-phenoxypropyl bromide 0.477 Hazardous Non Flammable 0.0954 HDPE drum / Poly bag ( By road)

Diethyl Ether 1.538 Hazardous Flammable 0.3076 HDPE drum / Poly bag ( By road)

Solifenacin Base 1.075 Hazardous Non Flammable 0.215 HDPE drum / Poly bag ( By road)



3-Amino-3-iminopropanoic

acid 1-(diphenyl methyl)3-

azetidinyl ester



(E)-isopropyl 2-(3-

nitrobenzylidene)-3-

oxobutanoate






2-

Methoxyethylacetoacetate[CI

L-MEAA]



m-Nitro Benzaldehyde 0.613 Hazardous Non Flammable 0.1226 HDPE drum / Poly bag ( By road)

Piperidine 0.021 Hazardous Non Flammable 0.0042 HDPE drum / Poly bag ( By road)




Cinnamyl acetoacetate ester [CIL-CAA] 0.649 Hazardous Non Flammable 0.1298 HDPE drum / Poly bag ( By road)

CIL-Methoxy Benzylidene 0.818 Hazardous Non Flammable 0.1636 HDPE drum / Poly bag ( By road)

Ammonium carbonate 1.169 Hazardous Non Flammable 0.2338 HDPE drum / Poly bag ( By road)

p-Toluene Sulphonic acid (PTSA) 0.117 Hazardous Non Flammable 0.0234 HDPE drum / Poly bag ( By road)

Purified water 3.896 Hazardous Non Flammable 0.7792 HDPE drum / Poly bag ( By road)


Existing ProductAclidinium

Bromide Hypertension

New Product

Sevelamer

Carbonate

Solifenacin

Succinate

CilnidipineHypertension

Azelnidipine

Migraine

Hypertension Existing Product

Existing Product

Hypertension Existing Product

Zolmitriptan

New Product

Migraine

Migraine New ProductEletriptan HBr

New ProductRimegepant Migraine

125

126

127

128

129

130

131

132



SAC-Amino 1.190 Hazardous Non Flammable 0.238 HDPE drum / Poly bag ( By road)

Succinic Anhydride 0.298 Hazardous Non Flammable 0.0596 HDPE drum / Poly bag ( By road)

Triethyl Amine 1.786 Hazardous Flammable 0.3572 HDPE drum / Poly bag ( By road)

1N HCl 0.714 Hazardous Non Flammable 0.1428 Container


Methyl 1-[[2'-(4,5-dihydro-5-

oxo-4H-1,2,4-oxadiazol-3-

yl)biphenyl]-4-yl]-2-ethoxy-

1H-benzimidazole-7-

carboxylate

1.111


0.2222






4-hydroxymethyl-5-methyl-

1,3-dioxol-2-one0.444



p-TSCl 0.556 Hazardous Non Flammable 0.1112 HDPE drum / Poly bag ( By road)

Dimethyl amino pyridine 0.044 Hazardous Non Flammable 0.0088 HDPE drum / Poly bag ( By road)

Dimethyl acetamide 4.444 Hazardous Non Flammable 0.8888 HDPE drum / Poly bag ( By road)



Potassium 2-ethylhexanoate 0.333 Hazardous Non Flammable 0.0666 HDPE drum / Poly bag ( By road)


4-(2-methoxy ethyl) phenol 1.429 Hazardous Non Flammable 0.2858 HDPE drum / Poly bag ( By road)




Water 5.714 Hazardous Non Flammable 1.1428 Container

Isopropylamine 3.100 Hazardous Flammable 0.62 HDPE drum / Poly bag ( By road)



Hyflow 0.243 Hazardous Non Flammable 0.0486 HDPE drum / Poly bag ( By road)


Methyl-2-(2-

nitrobenzylidene)acetoacetat

e



Methyl -3-aminocrotonate 0.600 Hazardous Non Flammable 0.12 HDPE drum / Poly bag ( By road)


Water 10.000 Hazardous Non Flammable 2 Container

CHL-Sulphonamide 1.250 Hazardous Non Flammable 0.25 HDPE drum / Poly bag ( By road)

50 % hydrogen peroxide 3.250 Hazardous Non Flammable 0.65 HDPE drum / Poly bag ( By road)




Benzothiazepinone 1.250 Hazardous Non Flammable 0.25 HDPE drum / Poly bag ( By road)

Acetic anhydride 0.875 Hazardous Flammable 0.175 HDPE drum / Poly bag ( By road)

DMAP 0.250 Hazardous Non Flammable 0.05 HDPE drum / Poly bag ( By road)

Sacubitril

Hypertension

Hypertension

Azilsartan

Medoxomil

Potassium

Hypertension

Metoprolol

succinate

CilnidipineHypertension

Hypertension Diltiazem Hydrochloride

Existing Product

New Product

New Product

New Product

Existing Product

Hypertension

Existing Product

Hypertension

Nifedipine

Chlorthalidone New Product

132

133

134

135

136

137

138

MDC 5.000 Hazardous Flammable 1 HDPE drum / Poly bag ( By road)

Ice water 8.750 Hazardous 1.75 Container

Dil. HCl 0.625 Hazardous Non Flammable 0.125 HDPE drum / Poly bag ( By road)

2n-propyl-4-methyl-6-(1-

methyl

benzimidizole-2-yl) Benz



Methyl-4-bromomethyl,1

biphenyl carboxylate1.111



Potassium Hydroxide 0.311 Hazardous Non Flammable 0.0622 HDPE drum / Poly bag ( By road)






Thiadiazol-3-tert butyl amino

propanol1.111



Morpholine 1.111 Hazardous Flammable 0.2222 HDPE drum / Poly bag ( By road)

Maleic acid 0.556 Hazardous Non Flammable 0.1112 HDPE drum / Poly bag ( By road)


Fimasartan Base 1.053 Hazardous Non Flammable 0.2106 HDPE drum / Poly bag ( By road)

2-Ethyl Hexanoic acid 0.553 Hazardous 0.1106 HDPE drum / Poly bag ( By road)







tert-Butyl Rosuvastatin

[ROS-TBU] 1.613 Hazardous Non Flammable 0.3226 HDPE drum / Poly bag ( By road)



Purified Water 12.903 Hazardous Non Flammable 2.5806 HDPE drum / Poly bag ( By road)


Calcium acetate 0.824 Hazardous Non Flammable 0.1648 HDPE drum / Poly bag ( By road)

Disulphide 1.124 Hazardous Non Flammable 0.2248 HDPE drum / Poly bag ( By road)

Magnesium turnings 0.124 Hazardous Flammable 0.0248 HDPE drum / Poly bag ( By road)

1 M Hydrochloric acid 11.236 Hazardous Non Flammable 2.2472 Container


Sodium chloride (Brine) 6.742 Hazardous Non Flammable 1.3484 HDPE drum / Poly bag ( By road)


Sodium sulphate 0.225 Hazardous Non Flammable 0.045 HDPE drum / Poly bag ( By road)



Isobutyryl chloride 0.382 Hazardous Non Flammable 0.0764 HDPE drum / Poly bag ( By road)



1 M Hydrochloric acid 11.236 Hazardous Non Flammable 2.2472 Container

1 M Sodium hydroxide 11.236 Hazardous Non Flammable 2.2472 Container


Hypertension Diltiazem Hydrochloride

New Product

New Product

Hypertension

Fimasartan

Potassium

Trihydrate

Existing Product

Hypertension

New ProductTimolol maleateHypertension

New ProductDalcetrapib

Existing ProductRosuvastatin

calcium

Hypertension

Hypertension Telmisartan

138

139

140

141

142

143

Brine 11.236 Hazardous Non Flammable 2.2472 Container

α-(3-Nitrobenzylidine)-

acetonylphosphonic acid 2,2-

dimethylpropylene ester

0.625


0.125


3-aminocrotonic acid 2-(N-

benzyl-N-phenyl)amino ethyl

ester






Trityl protected Olmesartan 2.000 Hazardous Non Flammable 0.4 HDPE drum / Poly bag ( By road)




VAL-Amine 2.500 Hazardous Non Flammable 0.5 HDPE drum / Poly bag ( By road)

Pentanoyl Chloride 0.625 Hazardous Non Flammable 0.125 HDPE drum / Poly bag ( By road)

N,N diisopropyl amine 3.750 Hazardous Non Flammable 0.75 HDPE drum / Poly bag ( By road)




Benzyl Valsartan 2.500 Hazardous Non Flammable 0.5 HDPE drum / Poly bag ( By road)


Cyclohexane 7.500 Hazardous Flammable 1.5 HDPE drum / Poly bag ( By road)



(S)-methyl 2-hydroxy-3-

methoxy- 1.124 Hazardous Non Flammable 0.2248 HDPE drum / Poly bag ( By road)

4,6-dimethyl-2-(methylsulfonyl)pyrimidine0.899 Hazardous Non Flammable 0.1798 HDPE drum / Poly bag ( By road)

Sodium Hydride (60%) 0.112 Hazardous Non Flammable 0.0224 HDPE drum / Poly bag ( By road)





Aq. Acetic acid 2.360 Hazardous Non Flammable 0.472 HDPE drum / Poly bag ( By road)

Potassium Hydroxide (1 N) 6.404 Hazardous Non Flammable 1.2808 HDPE drum / Poly bag ( By road)


Dioxane 1.124 Hazardous Flammable 0.2248 HDPE drum / Poly bag ( By road)

Hexane 3.371 Hazardous Flammable 0.6742 HDPE drum / Poly bag ( By road)

Perindopril 1.176 Hazardous Non Flammable 0.2352 HDPE drum / Poly bag ( By road)

L-arginine 5.012 Hazardous Non Flammable 1.0024 HDPE drum / Poly bag ( By road)


Dimethyl sulphoxide 7.412 Hazardous Flammable 1.4824 HDPE drum / Poly bag ( By road)

2-chloro-N-(2-methyl-1-

phenylpropan-2-yl) 2.500 Hazardous Non Flammable 0.5 HDPE drum / Poly bag ( By road)

Thiourea 0.925 Hazardous Non Flammable 0.185 HDPE drum / Poly bag ( By road)

Hydrochloric acid (Gas) 0.443 Hazardous Non Flammable 0.0886 HDPE drum / Poly bag ( By road)


Sacubitril 0.741 Hazardous Non Flammable 0.1482 HDPE drum / Poly bag ( By road)

Telmisartan 0.926 Hazardous Non Flammable 0.1852 HDPE drum / Poly bag ( By road)

New ProductAmbrisentan Hypertension

Hypertension Olmesartan

ValsartanHypertension New Product

New ProductDalcetrapib

Existing Product

New Product

Existing Product

Efonidipine

Hydrochloride

Ethanolate

Hypertension

Hypertension

Perindopril

ArginineHypertension

143

144

145

146

148

147

Existing Product

Phentermine

Hydrochloride149

Existing Product

Hypertension

Sacubitril

Telmisartan salt

Complex

Hypertension150




Isopropyl Acetate 7.407 Hazardous Non Flammable 1.4814 HDPE drum / Poly bag ( By road)

Valsartan 0.667 Hazardous Non Flammable 0.1334 HDPE drum / Poly bag ( By road)

Sacubitril 0.633 Hazardous Non Flammable 0.1266 HDPE drum / Poly bag ( By road)




Isopropyl acetate 6.667 Hazardous Non Flammable 1.3334 HDPE drum / Poly bag ( By road)

N-(3-aminopropionyl)-L-histidine 1.220 Hazardous Non Flammable 0.244 HDPE drum / Poly bag ( By road)

Zinc acetate 1.085 Hazardous Non Flammable 0.217 HDPE drum / Poly bag ( By road)

Sodium methoxide 0.293 Hazardous Non Flammable 0.0586 HDPE drum / Poly bag ( By road)


Water 12.195 Hazardous Non Flammable 2.439 By Tank

BEM-OXO 1.111 Hazardous Non Flammable 0.2222 HDPE drum / Poly bag ( By road)

Sodium Borohydride 0.600 Hazardous Non Flammable 0.12 HDPE drum / Poly bag ( By road)





Chlorosulphonic acid 1.026 Hazardous Non Flammable 0.2052 HDPE drum / Poly bag ( By road)

Formaldehyde 0.338 Hazardous Non Flammable 0.0676 HDPE drum / Poly bag ( By road)

Styrene-divinylbenzene

Copolymer beads0.728



40% Ferric chloride 0.024 Hazardous Non Flammable 0.0048 Container

20% Aq. Sodium hydroxide 1.026 Hazardous Non Flammable 0.2052 Container

40% Aq. Trimethylamine 1.221 Hazardous Non Flammable 0.2442 Container



3-(4-propylheptyl)morpholine 1.250 Hazardous Non Flammable 0.25 HDPE drum / Poly bag ( By road)

Oxirane 0.475 Hazardous Non Flammable 0.095 HDPE drum / Poly bag ( By road)




4-octylaminopyridine1.429




1,10-dichlorodecane 0.714 Hazardous Non Flammable 0.1428 HDPE drum / Poly bag ( By road)

Pyrocatechol 1.250 Hazardous Non Flammable 0.25 HDPE drum / Poly bag ( By road)

Bromine 7.263 Hazardous Non Flammable 1.4526 HDPE drum / Poly bag ( By road)

Methylene Chloride 7.500 Hazardous Flammable 1.5 HDPE drum / Poly bag ( By road)

Bismuth trioxide 1.369 Hazardous Non Flammable 0.2738 HDPE drum / Poly bag ( By road)

Delmopinol

Hydeochloride

Bempedoic Acid

Octinidine HCL

Antiseptic

Antiseptic

Hypercholesterolemia

PolaprezincTreatment of peptic ulcer

BibrocatholAntiseptic

New Product

New Product

New Product

New Product

New Product

CholestyramineHypercholesterolemia

New Product

New Product

New Product

152

153

154

155

156

157

Sacubitril

Telmisartan salt

Complex

Sacubitril

Valsartan salt

Complex

Hypertension

Hypertension

150

151

Ivabradine Base 1.429 Hazardous Non Flammable 0.2858 HDPE drum / Poly bag ( By road)

Isopropyl alcohol hydrochloride 0.561 Hazardous Flammable 0.1122 HDPE drum / Poly bag ( By road)


Lanthanum Oxide 1.563 Hazardous Flammable 0.3126 HDPE drum / Poly bag ( By road)




Trans-11-chloro-2,3,3a,12b-

tetrahydro-2-methyl-1H-

dibenz[2,3,6,7]oxepino [4,5-

c]pyrrol-1-one

1.111


0.2222


Aluminium chloride 0.763 Hazardous Non Flammable 0.1526 HDPE drum / Poly bag ( By road)

lithium aluminium hydride 3.878 Hazardous Non Flammable 0.7756 HDPE drum / Poly bag ( By road)

0.6 N Sodium hydroxide solution 11.111 Hazardous Non Flammable 2.2222 HDPE drum / Poly bag ( By road)

Purified water 11.111 Hazardous Non Flammable 2.2222 In Tank






2-amino-4-

Chlorodiphenylamine

Piperazine



Phosphorous oxy chloride 9.750 Hazardous Non Flammable 1.95 HDPE drum / Poly bag ( By road)

N,N Dimethyl aniline 0.224 Hazardous Non Flammable 0.0448 HDPE drum / Poly bag ( By road)



Ammonia 2.438 Hazardous Non Flammable 0.4876 HDPE drum / Poly bag ( By road)



Petroleum ether 5.000 Hazardous Flammable 1 HDPE drum / Poly bag ( By road)

2-(2'-hydroxy-3'-propyl amino

propoxy)-acetophenone

oxalate



Benzaldehyde 0.726 Hazardous Non Flammable 0.1452 HDPE drum / Poly bag ( By road)



water 2.288 Hazardous Non Flammable 0.4576 Container

10% Pd/C 0.137 Hazardous Flammable 0.0274 HDPE drum / Poly bag ( By road)

Hydrogen Gas 0.137 Hazardous Flammable 0.0274 Cylinder ( By Road)

1 N HCl 34.247 Hazardous Non Flammable 6.8494 Container

Lanthanum

CarbonateHyperphosphatemia

Ivabradine HCL

Asenapine

MaleateAntipsychotic

ClozapineAntipsychotic

Antianginal

New Product

New Product

Existing Product

New Product

New ProductPropafenone HCLAntiarrhythmic agent

158

159

160

161

162

Trientine 1.176 Hazardous Non Flammable 0.2352 HDPE drum / Poly bag ( By road)

Concentrated HCl 1.953 Hazardous Non Flammable 0.3906 HDPE drum / Poly bag ( By road)


Salicylamide 1.064 Hazardous Non Flammable 0.2128 HDPE drum / Poly bag ( By road)

Salicylic acid 1.181 Hazardous Non Flammable 0.2362 HDPE drum / Poly bag ( By road)

Thionyl chloride 1.564 Hazardous Non Flammable 0.3128 HDPE drum / Poly bag ( By road)


formaldehyde 6.383 Hazardous Non Flammable 1.2766 HDPE drum / Poly bag ( By road)


4-hydrazinobenzoic acid 0.447 Hazardous Non Flammable 0.0894 HDPE drum / Poly bag ( By road)


3-(3-

trifluoromethyl)phenyl)propy0.800



(R)-1-(naphthalene-1-yl)ethanamine 0.800 Hazardous Non Flammable 0.16 HDPE drum / Poly bag ( By road)

Lithium hydroxide 0.800 Hazardous Non Flammable 0.16 HDPE drum / Poly bag ( By road)


Sodium Bicarbonate 0.800 Hazardous Non Flammable 0.16 HDPE drum / Poly bag ( By road)




1-bromo-4-fluoro-

2((methoxymethoxy)methyl)

benzene



Triisopropyl Borate 4.146 Hazardous Non Flammable 0.8292 HDPE drum / Poly bag ( By road)

n-Butyl Lithium 11.024 Hazardous Flammable 2.2048 HDPE drum / Poly bag ( By road)

1 M HCl 20.293 Hazardous Non Flammable 4.0586 Container


(2R,3R)-2-(2,4-

difluorophenyl)-3-methyl-2-

[(1H-1,2,4-triazole-1-



4-Methylenepiperidine

Hydrochloride0.532 Hazardous Non Flammable 0.1064 HDPE drum / Poly bag ( By road)

Potassium hydroxide 0.224 Hazardous Non Flammable 0.0448 HDPE drum / Poly bag ( By road)

Ethyl Ether 3.000 Hazardous Flammable 0.6 HDPE drum / Poly bag ( By road)


Distilled Water 4.000 Hazardous Non Flammable 0.8 In Tank


LUL-(S) chloroethanol 1.299 Hazardous Non Flammable 0.2598 HDPE drum / Poly bag ( By road)

Methane sulfonyl chloride 0.584 Hazardous Non Flammable 0.1168 HDPE drum / Poly bag ( By road)





Carbon disulphide 0.429 Hazardous Flammable 0.0858 HDPE drum / Poly bag ( By road)

LUL-Imidazole 0.506 Hazardous Non Flammable 0.1012 HDPE drum / Poly bag ( By road)


DMSO 7.792 Hazardous Flammable 1.5584 HDPE drum / Poly bag ( By road)

TavaboroleAntifungal

LuliconazoleAntifungal

EfinaconazoleAntifungal

Hyperparathyroidism

Trientine

HydrochlorideChelating Agent

DeferasiroxChelating Agent

Existing Product

New Product

Existing Product

166+E1101167

New Product

Existing Product

Cinacalcet HCl

163

164

165

166

167

168



Fenticonazole-Imidazole KSM 0.709 Hazardous Non Flammable 0.1418 HDPE drum / Poly bag ( By road)

Sodium Hydride (60%) 0.082 Hazardous 0.0164 HDPE drum / Poly bag ( By road)

(4-(Chloromethyl)

phenyl)(phenyl) Sulfane 0.648 Hazardous Non Flammable 0.1296 HDPE drum / Poly bag ( By road)




Nitric acid 0.165 Hazardous Non Flammable 0.033 HDPE drum / Poly bag ( By road)


2-chloro-5-fluoropyrimidin-4-

amine1.639 Hazardous Non Flammable 0.3278 HDPE drum / Poly bag ( By road)


Voriconazole base (Racemic) 4.167 Hazardous Non Flammable 0.8334 HDPE drum / Poly bag ( By road)

R-(-)camphorsulphonic acid 2.750 Hazardous Non Flammable 0.55 HDPE drum / Poly bag ( By road)




Bremelanotide KSM I 1.166 Hazardous Non Flammable 0.2332 HDPE drum / Poly bag ( By road)

Bremelanotide KSM II 0.583 Hazardous Non Flammable 0.1166 HDPE drum / Poly bag ( By road)

N,N-Diisopropyl ethyl amine 0.146 Hazardous Flammable 0.0292 HDPE drum / Poly bag ( By road)






4-Cyano pyridine 1.111 Hazardous Non Flammable 0.2222 HDPE drum / Poly bag ( By road)

2-Cyanopyridine-4-

carbohydrazide(TOP-

hydrazide)



Sodium methoxide 0.577 Hazardous 0.1154 HDPE drum / Poly bag ( By road)


n-Butanol 7.778 Hazardous Flammable 1.5556 HDPE drum / Poly bag ( By road)

PTSA 9.333 Hazardous Non Flammable 1.8666 HDPE drum / Poly bag ( By road)

NaHCO3 (aq.solution) 5.556 Hazardous Non Flammable 1.1112 HDPE drum / Poly bag ( By road)


5-methyl-5, 6, 7, 8-

Tetrahydrofolic acid 1.250




Pet ether 6.250 Hazardous Flammable 1.25 HDPE drum / Poly bag ( By road)

Aq. Formaldehyde 7.913 Hazardous Non Flammable 1.5826 Container



7 % Glucosamine solution 9.375 Hazardous Non Flammable 1.875 Container

N1-(1-cyanocyclopropyl)-4-

fluoro-N2-{(1S)-2,2,2-trifluoro-

1-[4-yl]ethyl}-L-leucinamide1.316


0.2632


Odanacatib

FlucytosineAntifungal

TopiroxostatHyperuricemia

BremelanotideFemale sexual

dysfunction

Vitamin Supplement174

175Postmenopausal

osteoporosis

L- Methyl folate

Glucosamine

LuliconazoleAntifungal

New Product

Existing Product

New Product

New Product

New Product

Voriconazole

Antifungal

New Product

New Product

New ProductFenticonazole

Nitrate

Antifungal

168

169

170

171

172

173

Hydrogen peroxide 0.679 Hazardous Non Flammable 0.1358 HDPE drum / Poly bag ( By road)

Sodium tungstate dihydrate 0.010 Hazardous Non Flammable 0.002 HDPE drum / Poly bag ( By road)

Tetrabutylammoniumhydrog

en sulfate0.049




Sodium thiosulfate 1.316 Hazardous Non Flammable 0.2632 HDPE drum / Poly bag ( By road)

Ice 23.684 Hazardous Non Flammable 4.7368 Ice Slab ( By Road )

Brine solution 11.842 Hazardous Non Flammable 2.3684 Container

Diisopropylether 6.579 Hazardous Flammable 1.3158 HDPE drum / Poly bag ( By road)

L-erythro-biopterin 1.250 Hazardous Non Flammable 0.25 HDPE drum / Poly bag ( By road)

Platinum oxide 0.250 Hazardous Flammable 0.05 HDPE drum / Poly bag ( By road)

10% tetraethyl ammonium hydroxide 25.500 Hazardous Non Flammable 5.1 HDPE drum / Poly bag ( By road)

Concentrated hydrochloric acid 6.250 Hazardous Non Flammable 1.25 HDPE drum / Poly bag ( By road)


Water 12.500 Hazardous Non Flammable 2.5 in Tank


EDTA 1.000 Hazardous Non Flammable 0.2 HDPE drum / Poly bag ( By road)

DCC 0.700 Hazardous Non Flammable 0.14 HDPE drum / Poly bag ( By road)

EDA 7.200 Hazardous Non Flammable 1.44 HDPE drum / Poly bag ( By road)


Sevelamer HCl 0.435 Hazardous Non Flammable 0.087 HDPE drum / Poly bag ( By road)


6-Bromohexyl trimethyl

ammonium bromide 0.761Hazardous Non Flammable 0.1522 HDPE drum / Poly bag ( By road)

1-Bromodecane 0.457 Hazardous Non Flammable 0.0914 HDPE drum / Poly bag ( By road)


Sodium Chloride 0.870 Hazardous Non Flammable 0.174 HDPE drum / Poly bag ( By road)



1:1 Hydrochloric acid 0.870 Hazardous Non Flammable 0.174 Container

2-(1-methyl-3-oxo-3-phenyl

propenylamino)-3-[4(2-

bromomethoxy)phenyl]propi

onic acid

1.220


Carbazole 0.415 Hazardous Non Flammable 0.083 HDPE drum / Poly bag ( By road)


Tetrabutylammonium bromide 0.001 Hazardous Non Flammable 0.0002 HDPE drum / Poly bag ( By road)




TEN Acid 1.000 Hazardous Non Flammable 0.2 HDPE drum / Poly bag ( By road)

Dicyclohexyl carbodiimide 0.550 Hazardous Flammable 0.11 HDPE drum / Poly bag ( By road)

Thiazolidine 0.250 Hazardous Non Flammable 0.05 HDPE drum / Poly bag ( By road)

HOBt 0.378 Hazardous Non Flammable 0.0756 HDPE drum / Poly bag ( By road)

Dimethyl Formamide 5.000 Hazardous Flammable 1 HDPE drum / Poly bag ( By road)

Odanacatib

DendrimerDrug Delivery System

175

176

Postmenopausal

osteoporosis

Sapropterin

DihydrochlorideCoenzyme

177

178 Colesevelam HCLAnti-diabetic

Chiglitazar

Teneligliptin

Hydrobromide

Hydrate

Anti-diabetic

Anti-diabetic

New Product

New Product

Existing Product

Existing Product

New Product

New Product

179

180

6% Aq. acetic acid solution 3.000 Hazardous Non Flammable 0.6 Container

3.5 % Aq. Sodium

bicarbonate solution6.000 Hazardous Non Flammable 1.2 Container


Purified water 15.000 Hazardous Non Flammable 3 in Tank

10% Brine solution 3.000 Hazardous Non Flammable 0.6 Container


48% HBr 1.080 Hazardous Non Flammable 0.216 HDPE drum / Poly bag ( By road)

TEN crude 1.100 Hazardous Non Flammable 0.22 HDPE drum / Poly bag ( By road)

Purified Water 0.110 Hazardous Non Flammable 0.022 In Tank


(3R)-N-[(tert-Butoxycarbonyl)-

3-amino]-4-(2,4,5-

trifluorophenyl)butanoic acid

(SIT-Acid)

1.176


3-(Trifluoromethyl)-5,6,7,8-

tetrahydro[1,2,4]triazolo[4,3-

a]pyrazine

monohydrochloride (SIT-

0.965




DCC 1.059 Hazardous Flammable 0.2118 HDPE drum / Poly bag ( By road)


Conc.HCl 0.553 Hazardous Non Flammable 0.1106 HDPE drum / Poly bag ( By road)


2-((6-chloro-3,4-dihydro-3-

methyl-2,4-dioxopyrimidin-

1(2H)-yl)methyl)benzonitrile1.083


(R)-piperidin-3-amine

Dihydrochloride0.791 Hazardous Non Flammable 0.1582 HDPE drum / Poly bag ( By road)





CAN-ether 1.429 Hazardous Non Flammable 0.2858 HDPE drum / Poly bag ( By road)

Lithium Hydroxide 3.571 Hazardous Flammable 0.7142 HDPE drum / Poly bag ( By road)


Con. HCl 7.286 Hazardous Non Flammable 1.4572 HDPE drum / Poly bag ( By road)

Isopropyl Acetate 2.000 Hazardous Non Flammable 0.4 HDPE drum / Poly bag ( By road)



DAP-Ether 1.667 Hazardous Non Flammable 0.3334 HDPE drum / Poly bag ( By road)


1,2 Propane Diol 0.333 Hazardous Non Flammable 0.0666 HDPE drum / Poly bag ( By road)


Con. HCl solution 8.333 Hazardous Non Flammable 1.6666 HDPE drum / Poly bag ( By road)




BOC-Amino pyrrolidine 2.000 Hazardous Non Flammable 0.4 HDPE drum / Poly bag ( By road)

AlogliptinAnti-diabetic

Canagliflozin

HemihydrateAnti-diabetic

Teneligliptin

Hydrobromide

Hydrate

Anti-diabetic

Sitagliptin

PhosphateAnti-diabetic

Dapagliflozin

Propanediol

Monohydrate

Anti-diabetic

AnagliptinAnti-diabetic

New Product

Existing Product

Existing Product

New Product

Existing Product

New Product

180

181

182

184

185

183

Methane sulphonic acid 1.200 Hazardous Non Flammable 0.24 HDPE drum / Poly bag ( By road)


Acetonitrile 10.000 Hazardous Flammable 2 HDPE drum / Poly bag ( By road)

2-Methyl-pyrazolo [1,5-

a]pyrimidine-6-carboxylic

acid


1,1-Carbonyldiimidazole 1.360 Hazardous Non Flammable 0.272 HDPE drum / Poly bag ( By road)




S)-1-(2-

chloroacetyl)pyrrolidine-2-

carbonitrile (VIL-Pyrrolidine)


1-aminoadamantane-3-ol 1.386 Hazardous Non Flammable 0.2772 HDPE drum / Poly bag ( By road)

Potassium carbonate 1.714 Hazardous Non Flammable 0.3428 HDPE drum / Poly bag ( By road)

Dichloromethane (MDC) 14.286 Hazardous Flammable 2.8572 HDPE drum / Poly bag ( By road)


Methyl ethyl ketone 2.857 Hazardous Flammable 0.5714 HDPE drum / Poly bag ( By road)

8-Bromo-7-(but-2-ynyl)-3-

methyl-1-((4-

methylquinazolin-2-

yl)methyl)-1H-purine-

2.222


2-((R)-piperidin-3-

yl)isoindoline-1,3-dione.D-

tartarate ( LIN-Isoindoline

tartrate)

1.858


DIEA (N,N-Diisopropylethylamine) 1.267 Hazardous Non Flammable 0.2534 HDPE drum / Poly bag ( By road)

N-Methyl Pyrrolidine (NMP) 11.111 Hazardous Non Flammable 2.2222 HDPE drum / Poly bag ( By road)



2-Aminoethanol 0.644 Hazardous Non Flammable 0.1288 HDPE drum / Poly bag ( By road)


Trelagliptin base 1.429 Hazardous Non Flammable 0.2858 HDPE drum / Poly bag ( By road)




Benzyl protected Empagliflozin 2.500 Hazardous Non Flammable 0.5 HDPE drum / Poly bag ( By road)


Hydrogen Gas 0.006 Hazardous Flammable 0.0012 Cylinder (By Road)


IPR-Protected 2.500 Hazardous Non Flammable 0.5 HDPE drum / Poly bag ( By road)

Sodium Methoxide 0.728 Hazardous Non Flammable 0.1456 HDPE drum / Poly bag ( By road)


(S)-N-Boc-3-

Hydroxyadamantylglycine-L-

Cis-4,5-methanoprolinenitrile


Conc.Hydrochloric acid 0.818 Hazardous Non Flammable 0.1636 HDPE drum / Poly bag ( By road)





Anti-diabetic

IpragliflozinAnti-diabetic

Saxagliptin

VildagliptinAnti-diabetic

LinagliptinAnti-diabetic

AnagliptinAnti-diabetic

Trelagliptin

SuccinateAnti-diabetic

EmpagliflozinAnti-diabetic

New Product

New Product

Existing Product

Existing Product

New Product

New Product

New Product

185

186

190

191

187

188

189

Tert-butyl(1R,5S,6S)-[6-(tert-

butoxycarbonylaminomethyl)-

3-ethylbicyclo[3.2.0]hept-3-

en-6yl]acetate

2.500







2S,3S,4R,5S,6R)-2-(4-chloro-3

-(4-ethoxybenzyl)phenyl)-6-

(methylthio)

tetrahydro-2H-pyran-3,4,5-

trityl triacetate

1.351


Sodium methoxide 0.068 Hazardous Non Flammable 0.0136 HDPE drum / Poly bag ( By road)



Hydroxy Canagliflozin 1.429 Hazardous Non Flammable 0.2858 HDPE drum / Poly bag ( By road)


Triethyl silane 0.357 Hazardous Flammable 0.0714 HDPE drum / Poly bag ( By road)

BF3 Etherate 1.429 Hazardous Flammable 0.2858 HDPE drum / Poly bag ( By road)

Sodium bicarbonate solution 1.714 Hazardous Non Flammable 0.3428 HDPE drum / Poly bag ( By road)

DAP-Ether 1.176 Hazardous Non Flammable 0.2352 HDPE drum / Poly bag ( By road)

(S)-propane-1,2-diol 0.171 Hazardous Non Flammable 0.0342 HDPE drum / Poly bag ( By road)



DAP-Protected 1.667 Hazardous Non Flammable 0.3334 HDPE drum / Poly bag ( By road)

40% Methylamine 1.167 Hazardous Non Flammable 0.2334 HDPE drum / Poly bag ( By road)





Tert-butyl methyl ether 5.000 Hazardous Flammable 1 HDPE drum / Poly bag ( By road)

N-(2-(4-(E)-(2,4-

dimethyenethiazolidin -5-

ylidene)methyl)phenoxy)ethy

l)-2-(4-methoxyphenoxy)-N-

methylpyridin-4-amine

1.250


H2 gas 0.003 Hazardous Flammable 0.0006 Cylinder( By Road)


Pd(OH)2 0.304 Hazardous Flammable 0.0608 HDPE drum / Poly bag ( By road)

Benzyl-Luseogliflozin 2.000 Hazardous Non Flammable 0.4 HDPE drum / Poly bag ( By road)

Palladium Hydroxide on

Carbon0.200 Hazardous Flammable 0.04 HDPE drum / Poly bag ( By road)

Hydrogen 0.200 Hazardous Flammable 0.04 Cylinder (By Road)


Heptane 4.000 Hazardous Flammable 0.8 HDPE drum / Poly bag ( By road)

Hydroxy tofogliflozin 2.000 Hazardous Non Flammable 0.4 HDPE drum / Poly bag ( By road)

1,2 dimethoxyethane 6.000 Hazardous Non Flammable 1.2 HDPE drum / Poly bag ( By road)

Anti-diabetic

Canagliflozin

Dapagliflozin

PropanediolAnti-diabetic

Anti-diabetic

Mirogabalin

SotagliflozinAnti-diabetic

New Product

New Product

New Product

New Product

Anti-diabetic

New Product

New Product

Anti-diabetic Tofogliflozin

Luseogliflozin

Anti-diabetic Dapagliflozin

Lobeglitazone

Anti-diabetic

New Product

New Product

194

195

196

197

192

199

198

193





Bz-Gemigliptin 1.429 Hazardous Non Flammable 0.2858 HDPE drum / Poly bag ( By road)





Boc Evogliptin 1.923 Hazardous Non Flammable 0.3846 HDPE drum / Poly bag ( By road)


2N HCl in Diethyl ether11.538


5% Sodium hydrogen

carbonate aqueous solution 15.385Hazardous Non Flammable 3.077 HDPE drum / Poly bag ( By road)

Dichloromethane/2-Propanol

[4/1(v/v)] 9.615Hazardous Flammable 1.923 HDPE drum / Poly bag ( By road)

EMI-Phenol 1.282 Hazardous Non Flammable 0.2564 HDPE drum / Poly bag ( By road)



(Bromomethyl) cyclohexane 1.026 Hazardous Non Flammable 0.2052 HDPE drum / Poly bag ( By road)




IPA-HCl 2.564 Hazardous Flammable 0.5128 HDPE drum / Poly bag ( By road)

RET-BOC 1.449 Hazardous Non Flammable 0.2898 HDPE drum / Poly bag ( By road)





Isopropanol 4.348 Hazardous Flammable 0.8696 HDPE drum / Poly bag ( By road)

Phosphoric acid 0.580 Hazardous Non Flammable 0.116 HDPE drum / Poly bag ( By road)

Protected Ertugliflozin 2.326 Hazardous Non Flammable 0.4652 HDPE drum / Poly bag ( By road)

Palladium on Carbon 0.581 Hazardous Flammable 0.1162 HDPE drum / Poly bag ( By road)




Protected Omarigliptin 1.786 Hazardous Non Flammable 0.3572 HDPE drum / Poly bag ( By road)

Trifluoro acetic acid 0.409 Hazardous Flammable 0.0818 HDPE drum / Poly bag ( By road)





Semaglutide Crude 1.786 Hazardous Non Flammable 0.3572 HDPE drum / Poly bag ( By road)



New Product

New Product

Anti-diabetic

Anti-diabetic

Tofogliflozin

New Product

Anti-diabetic

Gemigliptin

Retagliptin Phosphate

Omarigliptin

New ProductEmixustat Hcl Anti-diabetic

New ProductEvogliptin Anti-diabetic

Anti-diabetic

Anti-diabetic Ertugliflozin

New Product

Semaglutide New Product

New Product

199

200

201

202

203

206

205

Anti-diabetic

204

2-(2-Ethoxyphenyl)-5-methyl-

7-propyl-3H-imidazo[5,1-

f][1,2,4] triazin-4-one (VAR-

Triazin)

1.111


0.2222


Chloro Sulphonic acid 2.222 Hazardous Non Flammable 0.4444 HDPE drum / Poly bag ( By road)


N-Ethylpiparazine 0.556 Hazardous Non Flammable 0.1112 HDPE drum / Poly bag ( By road)



Sodium Sulphate 0.778 Hazardous Non Flammable 0.1556 HDPE drum / Poly bag ( By road)


Sodium Chloride 0.667 Hazardous Non Flammable 0.1334 HDPE drum / Poly bag ( By road)




3-(5-ethyl-4,5-dihydro-4-oxo -

7-propyl-1H-pyrrolo[3,2-

d]pyrimidin-2-yl)-4-

propoxybenzene-1-sulfonyl

chloride

1.085


0.217



2-(piperazin-1-yl)ethanol 0.317 Hazardous Non Flammable 0.0634 HDPE drum / Poly bag ( By road)



Sildenafil 1.111 Hazardous Non Flammable 0.2222 HDPE drum / Poly bag ( By road)



Sildenafil Citrate IH / IP 0.667 Hazardous Non Flammable 0.1334 HDPE drum / Poly bag ( By road)

Mask IC-MK-9014 (white) III 0.667 Hazardous Non Flammable 0.1334 HDPE drum / Poly bag ( By road)

Purified Water 2.667 Hazardous Non Flammable 0.5334 In Tank

(1R,3R)-methyl 1-

(benzo[d][1,3]dioxol-5-yl)-

2,3,4,9-tetrahydro-1H-

pyrido[3,4-b]indole-3-

2.000


0.4



Chloroform 20.000 Hazardous Flammable 4 HDPE drum / Poly bag ( By road)

Chloroacetylchloride 1.000 Hazardous Non Flammable 0.2 HDPE drum / Poly bag ( By road)



Ether 4.000 Hazardous Flammable 0.8 HDPE drum / Poly bag ( By road)


Methylamine (33% in Ethanol) 2.140 Hazardous Flammable 0.428 HDPE drum / Poly bag ( By road)



Vardenafil HCL

TrihydrateErectile dysfunction

Erectile dysfunction

Erectile dysfunction209

Sildenafil citrate

Mask complexErectile dysfunction

MirodenafilErectile dysfunction

Sildenafil citrate

New Product

Existing Product

Existing Product

New Product

Tadalafil New Product

208

210

211

207

2-((3aS,4R,6S,6aR)-4-(7-

((1R,2S)-2-(3,4-

difluorophenyl)cyclopropyl

amino)-5-(propylthio)-3H-

[1,2,3]triazolo[4,5-

d]pyrimidin-3-yl)-tetrahydro-

2,2-dimethyl-3aH-

cyclopenta[d][1,3]dioxol-6-

0.909


0.1818







n-Heptane 3.636 Hazardous Flammable 0.7272 HDPE drum / Poly bag ( By road)

DEP-Napthol 1.087 Hazardous Non Flammable 0.2174 HDPE drum / Poly bag ( By road)

Methane sulfonyl Chloride 0.598 Hazardous Non Flammable 0.1196 HDPE drum / Poly bag ( By road)

Dimethyl amine 0.212 Hazardous Non Flammable 0.0424 HDPE drum / Poly bag ( By road)


DMA 0.130 Hazardous Non Flammable 0.026 HDPE drum / Poly bag ( By road)

HCl 0.380 Hazardous Non Flammable 0.076 HDPE drum / Poly bag ( By road)

E-Acetyldiene Cyclosporine 2.381 Hazardous Non Flammable 0.4762 HDPE drum / Poly bag ( By road)


Potassium Carbonate 6.667 Hazardous Non Flammable 1.3334 HDPE drum / Poly bag ( By road)


Ammonium chloride 7.143 Hazardous Non Flammable 1.4286 HDPE drum / Poly bag ( By road)


6,11-dihydro-11-(1-methyl-4-

piperidinylidene)-5H-imidazo-

[2,1-b][ 3]benzazepine-3-

methanol

1.923


0.3846


Manganese Oxide 9.615 Hazardous Non Flammable 1.923

Chloroform 28.846 Hazardous Flammable 5.7692 HDPE drum / Poly bag ( By road)



p-chlorobenzylacetophenone -

o - carboxylic acid 1.020Hazardous Non Flammable


Hydrazine 0.510 Hazardous Non Flammable 0.102 HDPE drum / Poly bag ( By road)




2-(2-chloroethyl)-N-

methylpyrrolidine 0.551 Hazardous Non Flammable 0.1102 HDPE drum / Poly bag ( By road)






4-Chlorobenzhydrol 1.163 Hazardous Non Flammable 0.2326 HDPE drum / Poly bag ( By road)

N-(2-chloroethyl) piperidine

Hydrochloride 1.174 Hazardous Non Flammable 0.2348 HDPE drum / Poly bag ( By road)


AlcaftadineAntihistamine

Azelastine HCLAntihistamine

AntihistamineCloperastine

Fendizoate

Platelet aggregation

inhibitor

VoclosporinImmunosuppressant

213

214

Ticagrelor

Dapoxetine HCL Premature

ejaculationExisting Product

New Product

Existing Product

New Product

New Product

New Product

212

215

216

217





Fendizoic acid 1.256 Hazardous Non Flammable 0.2512 HDPE drum / Poly bag ( By road)


Ethyl 2-(2, 4, 5-

Trimethoxybenzamido)-

thiazole-4-carboxylate1.333


0.2666


N, N-Dimethyl Acetamide 1.533 Hazardous Flammable 0.3066 HDPE drum / Poly bag ( By road)

2-Aminoethyl

Diisopropylamine 1.253 Hazardous Non Flammable 0.2506 HDPE drum / Poly bag ( By road)



Conc. Hydrochloric Acid 0.800 Hazardous Non Flammable 0.16 HDPE drum / Poly bag ( By road)


Activated carbon (NCASPF) 0.133 Hazardous Non Flammable 0.0266 HDPE drum / Poly bag ( By road)

Hyflo super cel 0.267 Hazardous Non Flammable 0.0534 HDPE drum / Poly bag ( By road)


3a-hydroxy-6-a-ethyliden-7-

keto-5b-cholanic acid1.176 Hazardous Non Flammable 0.2352 HDPE drum / Poly bag ( By road)

Sodium Hydride 0.225 Hazardous 0.045

5%Pd/C 0.118 Hazardous Flammable 0.0236 HDPE drum / Poly bag ( By road)

85% Phosphoric acid 0.749 Hazardous Non Flammable 0.1498 HDPE drum / Poly bag ( By road)


Sodium Borohydride 2.824 Hazardous Non Flammable 0.5648 HDPE drum / Poly bag ( By road)


85% Phosphoric acid 1.047 Hazardous Non Flammable 0.2094 HDPE drum / Poly bag ( By road)

Ammonia 0.294 Hazardous Non Flammable 0.0588 HDPE drum / Poly bag ( By road)


2,2,2-trifluoro-N-(3-(4-

phenoxyphenyl)-1-(piperidin-

3-yl)-1H-pyrazolo[3,4-

d]pyrimidin-4-yl)acetamide

1.250


0.25


Acryloyl chloride 0.233 Hazardous Non Flammable 0.0466 HDPE drum / Poly bag ( By road)







5-methyl-2(1H)-pyridone 1.053 Hazardous Non Flammable 0.2106 HDPE drum / Poly bag ( By road)

Copper 1.200 Hazardous Non Flammable 0.24 HDPE drum / Poly bag ( By road)

Iodo benzene 1.926 Hazardous Non Flammable 0.3852 HDPE drum / Poly bag ( By road)


Postprandial

PirfenidoneIdiopathic pulmonary

fibrosis

AntihistamineCloperastine

Fendizoate

Obeticholic AcidPrimary biliary

cholangitis

Ibrutinibchronic lymphocytic

leukemia

Existing Product

New Product

Acotiamide

Hydrochloride

Hydrate

New Product

New Product

New Product220

221

217

218

219


Pet ether 5.263 Hazardous Flammable 1.0526 HDPE drum / Poly bag ( By road)

Protected Vortioxetine 1.075 Hazardous Non Flammable 0.215 HDPE drum / Poly bag ( By road)




Aq. Hydrobromic acid (48 %) 0.017 Hazardous Non Flammable 0.0034 HDPE drum / Poly bag ( By road)


Sodium Hypochlorite 1.661 Hazardous Non Flammable 0.3322 HDPE drum / Poly bag ( By road)



Ethyl 6-(4-(5-

bromopentanamido)phenyl)-

4, 5, 6, 7-tetrahydro-1-(4-

methoxyphenyl)-7-oxo-

1H-pyrazolo[3,4-c] pyridine-3-

carboxylate

1.111


Potassium ethoxide 2.259 Hazardous Non Flammable 0.4518 HDPE drum / Poly bag ( By road)




Propylene glycol 6.611 Hazardous Non Flammable 1.3222 HDPE drum / Poly bag ( By road)

Anhydrous Ammonia 0.616 Hazardous Non Flammable 0.1232 HDPE drum / Poly bag ( By road)

17α-cyanomethyl-17β

hydroxyl-estra-5(10),9(11)-

diene-3-one-3-ethylene ketal1.163


0.2326





Cellulose 1.429 Hazardous Non Flammable 0.2858 HDPE drum / Poly bag ( By road)

2-chloroacetic acid 1.429 Hazardous Flammable 0.2858 HDPE drum / Poly bag ( By road)




Resorcinol 1.250 Hazardous Non Flammable 0.25 HDPE drum / Poly bag ( By road)

Hydrogen Peroxide 2.500 Hazardous Non Flammable 0.5 HDPE drum / Poly bag ( By road)

Sodium Thiosulfate 1.563 Hazardous Non Flammable 0.3125 HDPE drum / Poly bag ( By road)


5-hydroxy-6-methylpyridine-

3,4-dicarboxylic acid 1.086Hazardous Non Flammable


Sodium borohydride 0.208 Hazardous Non Flammable 0.0416 HDPE drum / Poly bag ( By road)

Carboxymethyl

cellulose sodium

Apixaban

Endometriosis Dienogest


Pyridoxine HCL

Hydroquinone Hyperpigmentation

PirfenidoneIdiopathic pulmonary

fibrosis

Emulsifier

Vortioxetine HBrAntidepressant

Dietary supplement


Hypochlorous

Acid

New Product

New Product

New Product

New Product

New Product

New Product

Existing Product

New Product

221

222

223

224

225

226

227

228






Carbonic acid, 5-[[3-amino-2-

(2-fluorobenzoyl)-1-oxo-2-

propen-1-yl]amino]-2,4-

bis(1,1-dimethylethyl)phenyl

methyl ester

1.299


0.2598






2-(3-Cyano-4-



acid ethyl ester (FEB-Ester)

1.208


0.2416




Sodium Hydroxide flakes 0.145 Hazardous Non Flammable 0.029 HDPE drum / Poly bag ( By road)




Febuxostat Crude 1.031 Hazardous Non Flammable 0.2062 HDPE drum / Poly bag ( By road)



Methyl-2-(5-bromo-4 (4-

cyclopropylnaphthalene -1-yl)-

4H-1,2,4-triazo-3yl-

thio)acetate

1.176


0.2352


Lithium hydroxide 0.588 Hazardous Non Flammable 0.1176 HDPE drum / Poly bag ( By road)




6-(4-methylpiperazin-1-yl)-4-

o-tolylpyridin-3-amine 1.163Hazardous Non Flammable


Trimethoxymethane 8.953 Hazardous Flammable 1.7906 HDPE drum / Poly bag ( By road)

Lithium Aluminium hydride 0.312 Hazardous Flammable 0.0624 HDPE drum / Poly bag ( By road)




Trifluoroacetic acid 0.047 Hazardous Flammable 0.0094 HDPE drum / Poly bag ( By road)



2-(3,5-bis(trifluoromethyl)

phenyl)-2-methylpropanoyl

chloride



N,N Diisopropyl ethyl amine 0.649 Hazardous Flammable 0.1298 HDPE drum / Poly bag ( By road)

Ivacaftorcystic fibrosis

Pyridoxine HCL

LesinuradHyperuricemia

FebuxostatHyperuricemia

Dietary supplement

Antiemetic

New Product

New Product

New Product

Existing Product

New ProductNetupitant

228

229

231

232

230




8- (benzoloxy)-5-(oxiran-2-yl)

quinoline-2(1H)-one 1.429Hazardous Non Flammable


5,6-diethyl-2,3-dihydro-1H-

inden-2-amine1.013



benzoic acid 0.643 Hazardous Non Flammable 0.1286 HDPE drum / Poly bag ( By road)







Hydrogen Gas 0.004 Hazardous Flammable 0.0008 HDPE drum / Poly bag ( By road)


5-(Piperazin-1-yl) benzofuran-

2-carboxamide 1.149Hazardous Non Flammable


3-(4-chlorobutyl)-1H-indole-5-

carbonitrile0.920




TBAB 0.230 Hazardous Non Flammable 0.046 HDPE drum / Poly bag ( By road)



IPA 9.195 Hazardous Flammable 1.839 HDPE drum / Poly bag ( By road)

Hydro bromic acid 0.805 Hazardous Non Flammable 0.161 HDPE drum / Poly bag ( By road)

Duloxetine Base 1.250 Hazardous Non Flammable 0.25 HDPE drum / Poly bag ( By road)



Calcium Citrate 1.111 Hazardous Non Flammable 0.2222 HDPE drum / Poly bag ( By road)





2, 3, 4, 5-tetrahydro-2[[5-

methyl-1- (triphenylmethyl) -

1H-imidazol-4-yl] methyl]-1H-

pyrido[4, 3-b]indol-1-one

2.500


0.5


Sodium hydride 0.285 Hazardous Non Flammable 0.057 HDPE drum / Poly bag ( By road)

0.5M Iodomethane in DMF 12.825 Hazardous Flammable 2.565 HDPE drum / Poly bag ( By road)





Vilazodone

Hydrobromide

AntidepressantDuloxetine

Hydrochloride

Antiemetic

Alosetron HCL

beta-adrenoceptor

agonist

Indacaterol

Maleate

Antidepressant

renal tubular

acidosis.

New Product

New Product

New Product

New Product

New Product

New Product

Potassium Citrate

5-HT3 antagonist

Netupitant

234

235

236

232

233

237




N-(5-chloro 2, 1, 3-

benzothiadiazole -4-yl)

Thiourea



Lead acetate 3.225 Hazardous Non Flammable 0.645 HDPE drum / Poly bag ( By road)


Glacial acetic acid 4.313 Hazardous Flammable 0.8626 HDPE drum / Poly bag ( By road)


Ethylene-diamine-mono-p-

toluene Sulphonate 2.688Hazardous Non Flammable



n-Pantanol 5.625 Hazardous Flammable 1.125 HDPE drum / Poly bag ( By road)



IPA.HCl 1.625 Hazardous Flammable 0.325 HDPE drum / Poly bag ( By road)

Isosorbitol dinitrate 2.000 Hazardous Flammable 0.4 HDPE drum / Poly bag ( By road)

Hydrazine hydrate 0.600 Hazardous Non Flammable 0.12 HDPE drum / Poly bag ( By road)

THF 5.000 Hazardous Flammable 1 HDPE drum / Poly bag ( By road)


Ethanol 10.000 Hazardous Flammable 2 HDPE drum / Poly bag ( By road)

Platinum oxide 0.100 Hazardous Flammable 0.02 HDPE drum / Poly bag ( By road)

Hydrogen gas 0.080 Hazardous Flammable 0.016 HDPE drum / Poly bag ( By road)


ENT-Vaniline 1.176 Hazardous Non Flammable 0.2352 HDPE drum / Poly bag ( By road)

Aluminium trichloride 0.478 Hazardous Non Flammable 0.0956 HDPE drum / Poly bag ( By road)





ENT-Cyano 0.824 Hazardous Non Flammable 0.1648 HDPE drum / Poly bag ( By road)

Diethyl amine 0.074 Hazardous Non Flammable 0.0148 HDPE drum / Poly bag ( By road)



Cytidine-5’-monoposphate 1.370 Hazardous Non Flammable 0.274 HDPE drum / Poly bag ( By road)




Uridine-5’-diphosphate 1.250 Hazardous Non Flammable 0.25 HDPE drum / Poly bag ( By road)



Monomer in RNA

Cytidine-5'-

disodium

monophosphate

Parkinson's disease

RNA

Uridine

Diphosphate

Disodium

Entacapone

Isosorbide

Mononitrate

antispasmodic drugs Tizanidine HCL

Alosetron HCL

angina pectoris

New Product

New Product

New Product

New Product

New Product

New Product

5-HT3 antagonist

238

239

240

241

242

237

Sodium iodide 1.375 Hazardous Non Flammable 0.275 HDPE drum / Poly bag ( By road)

2,4-Dichlorophenol 1.471 Hazardous Non Flammable 0.2942 HDPE drum / Poly bag ( By road)


Xylene 5.882 Hazardous Flammable 1.1764 HDPE drum / Poly bag ( By road)

Sulphuric Acid 0.735 Hazardous Non Flammable 0.147 HDPE drum / Poly bag ( By road)




1,3,5-tribromobenzene 2.703 Hazardous Non Flammable 0.5406 HDPE drum / Poly bag ( By road)

Sodium methoxide solution 0.473 Hazardous Non Flammable 0.0946 HDPE drum / Poly bag ( By road)


Activated Carbon 0.135 Hazardous Non Flammable 0.027 HDPE drum / Poly bag ( By road)


Pregn-4-ene-21-carboxylic

acid 17-hydroxy -7-mercapto-

3-oxo-, g-lactone, (7b,17a)-1.389


0.2778




Acetyl Chloride 0.350 Hazardous Non Flammable 0.07 HDPE drum / Poly bag ( By road)


9α-fluoro-11β, 16α, 17α, 21-

tetrahydroxy-1, 4-

pregnadiene-3, 20-Dione1.282


0.2564







N-[5-(3- chlorophenyl)-3-

methoxy pyridyl-2-

carbonyl)]glycine



Hydrobromic acid 4.839 Hazardous Non Flammable 0.9678 HDPE drum / Poly bag ( By road)



Amine hydrochloride salt1.136 Hazardous Non Flammable 0.2272 HDPE drum / Poly bag ( By road)

5-methyl-2-[l,2,3]triazol-2-yl-

benzoic acid 0.766



Potassium carbonate solution2.273



Isopropyl Acetate 5.682 Hazardous Flammable 1.1364 HDPE drum / Poly bag ( By road)


Cyano Ester Compound 1.667 Hazardous Non Flammable 0.3334 HDPE drum / Poly bag ( By road)

HMDS 0.933 Hazardous Non Flammable 0.1866 HDPE drum / Poly bag ( By road)


0.5 N Hydrochloric acid 2.000 Hazardous Non Flammable 0.4 HDPE drum / Poly bag ( By road)

Refractory edema Spironolactone

RNA

Uridine

Diphosphate

Disodium

ImmunosuppressiveTriamcinolone

Acetonide

AntispasmodicPhloroglucinol

Dihydrate

AntispasmodicTrimethyl

Phloroglucinol

New Product

New Product

New Product

New Product

New Product

Vadadustat Anemia and Non-dialysis

Finerenone Antimineralocorticoid

Insomnia

New Product

New ProductSuvorexant

New Product

243

244

246

249

242

245

247

248


VIL-diol 1.754 Hazardous Non Flammable 0.3508 HDPE drum / Poly bag ( By road)


KHSO5 7.018 Hazardous Non Flammable 1.4036 HDPE drum / Poly bag ( By road)




NaCl 0.439 Hazardous Non Flammable 0.0878 HDPE drum / Poly bag ( By road)

5-(tetradecycloxy) furan-2-

carboxylic acid 1.370



ethyl 2-(2-chloro-N-

methylacetamido)acetate0.822




TEA 0.205 Hazardous Flammable 0.041 HDPE drum / Poly bag ( By road)



L-Proline, 1-[(2'-methyl[1,1'-

biphenyl]-4-yl)carbonyl]-4-

oxo-

1.370Hazardous Flammable


O-Methylhydroxylamine

hydrochloride

0.616 Hazardous Non Flammable 0.1232 HDPE drum / Poly bag ( By road)

Dimethyl sulfate 0.685 Hazardous Non Flammable 0.137 HDPE drum / Poly bag ( By road)

Tri ethyl amine 0.685 Hazardous Flammable 0.137 HDPE drum / Poly bag ( By road)


Lithium borohydride 0.479 Hazardous Flammable 0.0958 HDPE drum / Poly bag ( By road)






1-(2,7-dichloro-9H-fluoren-5-

yl)-2-(dibutylamino)ethanol1.429




4-chlorobenzaldehyde 0.493 Hazardous Non Flammable 0.099 HDPE drum / Poly bag ( By road)


Dihydroartemesinin 2 Hazardous Non Flammable 0.4 HDPE drum / Poly bag ( By road)

Methanol 8 Hazardous Flammable 1.6 HDPE drum / Poly bag ( By road)

Water 20 Hazardous Non Flammable 4 In Tank

Aq. Hydrochloric Acid 1 Hazardous Non Flammable 0.2 HDPE drum / Poly bag ( By road)

4-methoxy isophthalic acid 0.667 Hazardous Non Flammable 0.1334 HDPE drum / Poly bag ( By road)

Thionyl chloride 1.533 Hazardous Non Flammable 0.3066 HDPE drum / Poly bag ( By road)

3-amino methyl pyridine 0.8 Hazardous Non Flammable 0.16 HDPE drum / Poly bag ( By road)



Dimethyl formamide 0.067 Hazardous Flammable 0.0134 HDPE drum / Poly bag ( By road)



(+)-(s)-Clopidogrel-camphor-sulfonate 1.316 Hazardous Non Flammable 0.2632 HDPE drum / Poly bag ( By road)


Sulfuric acid 0.368 Hazardous Non Flammable 0.0736 HDPE drum / Poly bag ( By road)



Finerenone Antimineralocorticoid

New ProductVilaprisan

New Product

Endometriosis

New ProductOlumacostat Glasaretil Acne Vulgaris.

252 Pyrrolidinones Nolasiban New Product

251

249

250

Existing Product

Existing ProductClopidogrel

BisulfateAntiplatelet drug256

Picotamide Existing ProductAntiplatelet drug255

ArtemetherAnti-malerrial254

LumefantrineAnti-malerrial Existing Product253


Montelukast Acid2




Methanol 8 Hazardous Flammable 0.8 Flammable

Existing ProductMontelukast

Sodium

leukotriene receptor

antagonist257

Existing ProductClopidogrel

BisulfateAntiplatelet drug256

Master list of Equipment

Department : Maintenance Page Number : Page 1 of 17

Effective Date : Review Date : Version : 13

MASTER LIST OF EQUIPMENT

APPROVAL:

Prepared by Checked by Authorized by

Signature

Date

Name

Designation

ANNEXURE-5




Sr. No.

Name Location New ID No. Make Model Capacity

1. Glass Lined Reactor

First Floor W/PR/GR/001 GMM Pfaudler

----- 2000 L


First Floor W/PR/GR/002 GMM Pfaudler

----- 250 L


Second Floor W/PR/GR/003 GMM Pfaudler

----- 1000 L



----- 500 L



----- 500 L



----- 500 L

7. Stainless Steel Reactor

First Floor W/PR/SR/001 Finefab India ----- 1000 L


First Floor W/PR/SR/002 Finefab India ----- 500 L


First Floor (Crystallizer area)

W/PR/SR/003 Finefab India ----- 1000 L


First Floor Pilot Plant W/PR/SR/004 Progressive Engineering

----- 50 L


First Floor Pilot Plant W/PR/SR/005 Progressive Engineering

----- 50 L


Second Floor W/PR/SR/006 Finefab India ----- 2000 L

13. Glass Reactor Pilot Plant 2

Crystallizer area W/PR/GL/001

Sigma Scientific

----- 100 L

14. Glass Reactor First Floor Pilot Plant W/PR/GL/002 Sigma Scientific

----- 50 L

15. Glass Reactor First Floor Pilot Plant W/PR/GL/003 Sigma Scientific

----- 20 L

16. Centrifuge Ground floor W/PR/CF/001 Aim Industries 905 36”

17. Centrifuge Ground floor W/PR/CF/002 Aim Industries 905 36”

18. Centrifuge Pilot Plant 2

Crystallizer area W/PR/CF/003 Aim Industries 60:5 24”

19. Tray Dryer Ground floor W/PR/TD/001 Sunsai Pharma STD-48 48 Trays

20. Fluid Bed Dryer Ground floor W/PR/FBD/001 Propack Technologies

----- 120 Kg

21. Agitated Nutch filter dryer

Ground floor (PP area)

W/PR/ANFD/001 Befriends Engineering

----- 1000 L




Sr. No.


22. Octagonal Blender

Ground floor (PP area)

W/PR/OB/001 Sunsai Pharma SCOB-400/150

400/50Lit 200/25Kg

23. Multimill Ground floor (PP

area) W/PR/MM/001 Sunsai Pharma SUN-MMS

50 to 200 Kg/hr

24. Multimill Pilot plant-

1(Crystallizer area) W/PR/MM/002 Bharati Engg. ----- 5 Kg/hr

25. Vibro Sifter Ground floor (PP

area) W/PR/VS/001 Sainath Boilers ----- 200 Kg/hr

26. Heat Exchanger First Floor Mezzanine

W/PR/HE/001 Blast Carbo BCAHEX

100/40 4.4 m2



100/80 8.8 m2



100/30 3.3 m2



100/20 2.0 m2


W/PR/HE/005 Tamhane Engineering

----- 5.0 m2



----- 3.0 m2



----- 5.0 m2



----- 3.0 m2



----- 5.0 m2



----- 3.0 m2

36. Heat Exchanger First floor Pilot

Plant W/PR/HE/011

Sigma Scientific

----- 5.0 m2


Plant W/PR/HE/012 Sigma Scientific ----- 5.0 m2










Sr. No.












46. Heat Exchanger Second floor Mezzanine

W/PR/HE/021 Blast Carbo BACHEX

100/30 3.3 m2



100/50 5.5 m2



100/30 3.3 m2



100/30 2.2 m2



----- 8.0 m2



----- 5.0 m2



100/20 2.2 m2



100/30 3.3 m2



100/30 3.3 m2



100/20 2.2 m2

56. Heat Exchanger Outside Utility W/MS/HE/001 Alfa level ----- 1.4 m2

57. Heat Exchanger Outside Utility W/MS/HE/002 Alfa level ----- 1.12 m2

58. Heat Exchanger Outside Utility W/MS/HE/003 Finefab ----- 8.8 m2

59. Sparkler Filter First Floor W/PR/SF/001 Prakin

Equipment ----- 12 Plate

60. Nutsche Filter First Floor W/PR/NF/001 Lester &

Dynamiks NF 701 130 L

61. Nutsche Filter Ground floor W/PR/NF/002 Lester &

Dynamiks

----- 130 L




Sr. No.



Dynamiks ----- 130 L


Dynamiks ----- 30 L

64. Vertical Tank Outside Ground

floor W/PR/VT/001

Prakin Equipment

----- 50 L


floor W/PR/VT/002 Sarita ----- 1.5 KL


floor W/PR/VT/003 Sarita ----- 1.5 KL


floor W/PR/VT/004

Lester & Dynamiks

----- 1 KL


floor W/PR/VT/005

Lester & Dynamiks

----- 1 KL


floor W/PR/VT/006

Prakin Equipment

----- 50 L


floor W/PR/VT/007

Lester & Dynamiks

----- 1 KL


floor W/PR/VT/008

Lester & Dynamiks

----- 1 KL


floor W/PR/VT/009

Lester & Dynamiks

----- 1 KL


floor W/PR/VT/010

Prakin Equipment

----- 50 L

74. Vertical Tank First Floor W/PR/VT/011 Prakin

Equipment ----- 500 L





77. Vertical Tank Utility W/MS/VT/001 Maxitherm ----- 1.5 KL

78. Vertical Tank Utility W/MS/VT/002 Sarita ----- 1.5 KL

79. Vertical Tank Utility W/MS/VT/003 Sarita ----- 1.5 KL

80. Vertical Tank Purified Water

System W/MS/VT/004 Komal ----- 500 L

81. Vertical Tank ETP W/MS/VT/005 Sarita ----- 2.5 KL

82. Vertical Tank ETP W/MS/VT/006 Sarita -----

2.5 KL




Sr. No.


83. Vertical Tank Outside Utility W/MS/VT/007 Aerocool ----- 6 KL

84. Vertical Tank Outside Utility W/MS/VT/008 Aerocool ----- 4 KL

85. Vertical Tank Outside Utility W/MS/VT/010 Emkay

Engineers ----- 300 L





88. Vertical Tank Outside Utility W/MS/VT/013 Geol. power ----- 1 KL

89. Expansion Tank Second floor W/MS/EXT/001 Galaxy ----- 500 L

90. Ethanol tank Solvent Store W/STR/ET/001 Lester &

Dynamics ----- 6 KL

91. Receiver First Floor W/PR/RCR/001 Garg Brothers ----- 50 L




95. Receiver First Floor Mezzanine

W/PR/RCR/005 Prakin



W/PR/RCR/006 Prakin



W/PR/RCR/007 Prakin



W/PR/RCR/008 Prakin


99. 1 Receiver First floor Crystallizer

W/PR/RCR/009 Prakin


100. Receiver First floor Crystallizer

W/PR/RCR/010 Prakin


101. Receiver First floor Pilot

Plant W/PR/RCR/011 Sigma Scientific ----- 10 L

102. 1 Receiver First floor Pilot









Sr. No.



Plant (Crystallizer area)

W/PR/RCR/015 Sigma Scientific ----- 10 L

106. 1 Receiver Second floor Mezzanine

W/PR/RCR/016 Garg Brothers ----- 50 L







110. Receiver Second floor Mezzanine

W/PR/RCR/020 Prakin



W/PR/RCR/021 Prakin







W/PR/RCR/024 Prakin





W/PR/RCR/026 Prakin




118. 1 Receiver First Floor W/PR/RCR/028 Garg Brothers ----- 100 L

119. Receiver Ground floor W/PR/RCR/029 Garg Brothers ----- 50 L

120. 1 Receiver Ground floor W/PR/RCR/030 Garg Brothers ----- 50 L

121. 1 Air Receiver Outside Utility W/MS/ARC/001 Chicago

Pneumatic ----- 1 KL

122. 1 Boiler Utility W/MS/BR/001 Thermax RXD1-

850/10.54/8 850 Kg/hr

123. 1 Boiler Utility W/MS/BR/002 Thermax RXD1-

850/10.54/11 850 Kg/hr

124. 1 Chiller Utility W/MS/CHR/001 Blue Star XWC 35-

039A

39 TR




Sr. No.


125. 1 Chiller Utility W/MS/CHR/002 Blue Star XWC 35-

039A 39 TR

126. 1 Chiller Utility W/MS/CHR/003 Aerocool ----- 30 TR

127. 1 Chiller Outside Utility W/MS/CHR/004 Aerocool (Water)

----- 8 TR

128. 1 Chiller Outside Utility W/MS/CHR/005 Aerocool (Brine)

----- 6 TR

129. 1 Nitrogen Plant Utility W/MS/NGP/001 Airox Nigen ASME SEC

VIII 25 Nm3/hr

130. 1 Air Compressor Utility W/MS/ACR/001 Chicago

Pneumatic CPB30 112 CFM

131. 1 Cooling tower Outside Utility W/MS/CTR/001 Himgiri ----- 200 TR



134. 1 Wet Scrubber Outside Utility W/MS/SCR/001 Bhaviplast ----- 3400 CFM

135. 1 Water Softener Outside Utility W/MS/WS/001 Thermax ----- 300 L

136. 1 LDO Tank Outside Utility W/MS/LDO/001 Maxitherm ----- 8 KL

137. 1 Transformer Outside Utility W/MS/TRF/001 Tran delta DYN11 630 KVA

138. Diesel Generator Outside Utility W/MS/DG/001 Kirloskar KG400W 400 KVA

139. Diesel Generator Outside Utility W/MS/DG/002 Kirloskar KG30WS2 30 KVA

140. Power control center

Utility W/MS/PCC/001 Chandra Electrical

----- NA

141. Process MCC Utility W/MS/MCC/001 Chandra Electrical

----- NA

142. 1 Utility MCC Utility W/MS/MCC/002 Chandra Electrical

----- NA

143. 1 Automatic power factor control

Utility W/MS/APFC/001 Baron Power ----- 300 KVAR

144. 1 Uninterrupted Power Supply

First floor service area

W/MS/UPS/001 Power gun UPS30 30 KVA

145. Air Handling Unit

Utility W/MS/HVAC/001 Citizen

Industries -----

3500 CFM




Sr. No.




W/MS/HVAC/002 Citizen

Industries ----- 2435 CFM










First floor microbiology



150. Raw Water Tank Pump House W/MS/RWT/001 NA ----- 36 KL

151. Raw Water Tank Pump House W/MS/RWT/002 NA ----- 36 KL

152. Raw Water Tank Third floor W/MS/RWT/003 NA ----- 36 KL

153. Raw Water Tank Third floor W/MS/RWT/004 NA ----- 24 KL

154. Fire Water Tank Pump House W/MS/FWT/001 NA ----- 129 KL

155. Fire Water Tank Pump House W/MS/FWT/002 NA ----- 129 KL

156. Purified Water System

Second floor W/MS/PWS/001 Komal

Industries ----- 500 L/hr

157. Effluent Treatment Plant

ETP W/MS/ETP/001 Kwan ----- 25m3/day

158. Blower ETP W/MS/BL/001 Everest Blower M5075 200m3/hr

159. Blower ETP W/MS/BL/002 Everest Blower M5075 200m3/hr

160. Blower ETP W/MS/BL/003 Everest Blower EXP0-II 400m3/hr

161. Blower ETP W/MS/BL/004 Everest Blower EXP0-II 400m3/hr

162. Pump Pump House W/MS/CP/001 Grundffoss ----- 33m3/hr

163. Pump Pump House W/MS/CP/002 Grundffoss ----- 33m3/hr

164. Pump ETP W/MS/CP/003 Kirloskar ----- 14m3/hr









Sr. No.


170. Pump ETP W/MS/CP/009 Kirloskar ----- 2HP

171. Pump ETP W/MS/CP/010 Kirloskar ----- 2HP

172. Pump Pump House W/MS/CP/011 Mather & Platt ----- 137m3/hr

173. Pump Pump House W/MS/CP/012 Mather & Platt ----- 10.8m3/hr

174. Pump Ethanol tank W/MS/CP/013 Grundffoss ----- 3m3/hr

175. Pump Outside Utility W/MS/CP/014 KSB ----- 45m3/hr




179. Pump Outside Utility W/MS/CP/018 KSB ----- 27.29m3/hr











190. Pump Outside Utility W/MS/CP/029 Raje-dia pump ----- 16m3/hr

191. Pump Outside Utility W/MS/CP/030 Raje-dia pump ----- 16m3/hr

192. Pump Outside Ground

floor W/MS/CP/031 KSB ----- 5m3/hr


floor W/MS/CP/032 KSB ----- 5m3/hr

194. Pump Cooling Tower W/MS/CP/033 Kirloskar ----- 36m3/hr




Sr. No.


195. Pump Cooling Tower W/MS/CP/034 Kirloskar ----- 36m3/hr

196. Pump Purified Water

System W/MS/CP/035 Grundffoss ----- 2.5m3/hr


System W/MS/CP/036 Grundffoss ----- 2.5m3/hr


System W/MS/CP/037 Grundffoss ----- 2m3/hr





201. Pump Heating System W/MS/CP/040 Sulzer CC 40x32-160 1m3/hr

202. Pump Heating System W/MS/CP/041 Sulzer CC 40x32-

160 1m3/hr


160J 1m3/hr


160J 1m3/hr

205. Pump First Floor Mezzanine

W/PR/CP/001 Grundffoss ----- 0.9m3/hr


floor W/PR/CP/002 Grundffoss ----- 1.8m3/hr











212. Pump Ground floor W/PR/CP/008 Grundffoss ----- 3m3/hr

213. Pump Ground floor W/PR/CP/009 Grundffoss ----- 3m3/hr


W/PR/CP/010 Grundffoss ----- 1.8m3/hr


W/PR/CP/011 Grundffoss -----

0.9m3/hr




Sr. No.


216. Water ring Vacuum Pump

Outside Ground floor

W/PR/WP/001 H K Industries ----- 340m3/hr



W/PR/WP/002 H K Industries ----- 340m3/hr

218. Vacuum Pump Outside Ground

floor W/PR/VP/001

Acmevac pumps

----- 0.002

219. Vacuum Pump First floor Pilot

plant W/PR/VP/002

Acmevac pumps

----- 0.002

220. Air Curtain Ground floor W/PR/AC/001 Envair

Elecrodyne ----- 1HP

221. Air Curtain Ground floor W/PR/AC/002 Envair

Elecrodyne ----- 1HP

222. Water cooler Outside Ground

floor W/MS/WC/001 Aqua mall ----- 20 L

223. Water cooler Canteen W/MS/WC/002 Eureka Forbes OOKSOLx24

00 40 L

224. Vacuum Oven Pilot plant

(Crystallizer area) W/PR/OVN/001 Kumar ----- 2 KW

225. Fire Hydrant System

Pump House W/MS/FHS/001 NA ----- 144 m3

226. Steam Ejector Terrace floor W/MS/SE/001 Cor-resist Pvt.

Ltd. -----

400CFM at 1 torr

227. Hand Pallet Truck

Production W/PR/HPT/001 Nilkamal ----- 1000 Kg

228. Hand Pallet Truck

Store W/ST/HPT/002 Nilkamal ----- 1000 Kg

229. Dispensing booth

Store W/ST/DB/001 Envirnotech ----- 1028 CFM

230. Glass Reactor Pilot Plant 2 W/PR/GL/005 Sigma

Scientific glass Pvt.Ltd.

----- 50 L.

231. Glass Reactor Pilot Plant 2 W/PR/GL/004 Sigma


----- 20 L

232. Stainless Steel

Reactor Pilot Plant 2 W/PR/SR/007

Prakin Equipments

----- 50 L

233. Rota vapor assembly

Pilot Plant 2 W/PR/RV/001 Buchi -----

20 L




Sr. No.


234. SS centrifuge First floor Pilot

Plant Crystallizer area

W/PR/CF/004 Aim Industries 30:5 950 x 300

mm

235. SS vacuum oven Pilot Plant 1 W/PR/OV/003 Kumar Sales & Services

----- 200Lit

236. SS sparkler filter First floor W/PR/SF/002 Prakin

Equipments -----

8” X 6 Plates

237. Hallar coated Nutsche filter

Pilot Plant 2 Crystallizer area

W/PR/NF/005 Aim Industries ----- 18”

238. Heat Exchanger Pilot Plant 2 W/PR/HE/031 Sigma


----- 3 m2



----- 2 m2



----- 3 m2



----- 2 m2



----- 3 m2

243. Heat Exchanger Pilot Plant 2

Crystallizer area W/PR/HE/036

Sigma Scientific glass

Pvt.Ltd. ----- 2 m2

244. Vacuum Cleaner Store W/ST/VC/001 Roots ----- 23 L

245. Vacuum Cleaner Production area W/PR/VC/001 Roots ----- 23 L

246. Insect killer Plant entrance lobby

W/PR/IK/001 PCI ----- NA

247. Insect killer Store receiving bay

W/ST/IK/001 PCI ----- NA

248. Split AC Unit Finish goods

Store W/MS/SAC/001 Agure ----- 1.5 Ton

249. Split AC Unit Finish goods

Store W/MS/SAC/002 Agure 3HW24SVB 1.5 Ton

250. Split AC Unit Administration

Block W/MS/SAC/003 Carrier -----

1.5 Ton




Sr. No.



Block W/MS/SAC/004 Carrier ----- 1.5 Ton


Block W/MS/SAC/005 Carrier ----- 1.5 Ton


Block W/MS/SAC/006 Carrier ----- 2 Ton





256. Split AC Unit QC Office W/MS/SAC/009 LG ----- 2 Ton

257. Split AC Unit Media Preparation W/MS/SAC/010 Smart ----- 2 Ton

258. Split AC Unit Instrument lab W/MS/SAC/011 Carrier ----- 2 Ton

259. Split AC Unit Wet Analysis lab W/MS/SAC/012 Carrier ----- 2 Ton

260. Split AC Unit Control Sample room

W/MS/SAC/013 NA ----- 2 Ton

261. Split AC Unit Production Office W/MS/SAC/014 LG ----- 2 Ton


Terrace floor W/MS/HVAC/006 Citizen


263. Supply Fan Canteen W/MS/SF/001 Rohini ----- 24”

264. Supply Fan Ground floor W/MS/SF/002 Rohini ----- 24”



267. Supply Fan First floor W/MS/SF/005 Rohini ----- 24”




271. Supply Fan First floor Pilot

plant W/MS/SF/009 Rohini ----- 24”

272. Supply Fan Second floor W/MS/SF/010 Rohini ----- 24”





Sr. No.






278. Supply Fan Utility W/MS/SF/016 Rohini ----- 24”




282. Exhaust Fan Canteen W/MS/EF/001 Rohini ----- 24”

283. Exhaust Fan Ground floor W/MS/EF/002 Rohini ----- 24”

284. Exhaust Fan Ground floor W/MS/EF/003 Rohini ----- 24”

285. Exhaust Fan First floor W/MS/EF/004 Rohini ----- 24”





290. Exhaust Fan First floor Pilot

plant W/MS/EF/009 Rohini ----- 24”

291. Exhaust Fan First floor Pilot

plant W/MS/EF/010 Rohini ----- 18”

292. Exhaust Fan Second floor W/MS/EF/011 Rohini ----- 24”






298. Exhaust Fan Utility W/MS/EF/017 Rohini ----- 24”




Sr. No.





302. SS oven QC W/QC/OV/001 Kumar Sales & Services

TVOOOOO284

2 KW

303. Spiral Jet mill P.P area W/PR/SJM//001 Rucha Pharma RPS 05 Kg /hr

304. Rotary Vacuum Paddle Dryer

Ground floor W/PR/RVD/001 Millennium Equipments

MERVPD 1000G

400 Kg.

305. Octagonal

blender Pilot plant-

2Crystallizer area W/PR/OB/002

Vignesh Techno steel

----- 20Kg/40

Lit.

306. Air Compressor Outside Utility W/MS/ACR/002 Chicago

Pneumatic SXN-050 238 CFM

307. Air Receiver Outside Utility W/MS/ARC/002 Chicago

Pneumatic N/A 1 KL

308. Vibro Sifter Pilot plant-

2Crystallizer area W/PR/VS/002

M/s. Vignesh techno steel products Pvt. Ltd

----- 1 to 40 Kg/hr

309. Nutsche Filter ANFD Room W/PR/NF/006

Shre Sai Sangam

Engineering (India)

----- 60 L

310. Ethylene Oxide

Sterilizer PP Quarantine area

W/PR/ETO/001 Pest Control

India SAE,5CF 50Kg.


Pilot Plant-2 W/PR/SR/009 Bombay Engg ----- 150 L

312. Vacuum Tray Dryer

Pilot plant-2Crystallizer area

W/PR/VTD/001 Bombay Engg

----- 50 Kg

313. Vertical Tank ETP W/MS/VT/014 Sintex ----- 5KL

314. Tray Dryer Ground Floor FBD

Area W/PR/TD/002

Sai Sangum Engg.

----- 26 Tray

315. Eye Washer Near Solvent Store

Ground floor W/ST/EWR/001 N/A ----- N/A

316. Vertical Tank Outside Utility W/MS/VT/015 Prakin ----- 500 L




Sr. No.


317. Glass Column First pilot plant W/PR/CLM/001 SV Glass

Industries LTD NA NA

318. Exhaust Fan Main entrance

production w/c room

W/MS/EF/021 Almondro EXF12 12”

319. SS centrifuge ETP Area W/EHS/CF/001 D Parekh HEL/24” 70 Kg

320. Sewage

Treatment Plant ETP Outside area W/EHS/STP/001

Indochem treatment plant

----- 10 kld

321. Pump Second floor purified water

System W/MS/CP/044 Grundffoss

A98640342 P11510

15 m³/HRS

322. Hooter

First floor (Production Emergency exit door )

W/PR/HOTR/001 Target

Electricals 966 HS-A5 NA

323. Hooter

Second floor (Production Emergency exit door )

W/PR/HOTR/002 Target


324. Hooter Store Finish goods

W/ST/HOTR/001 Target


325. Hooter Control sample W/QA/HOTR/001 Target


326. Digital online monitoring system of ETP.

ETP W/EHS/DOMS/001

Trios GmbH Germany

Opus NA



W/PR/WP/003 NA WR-130 130/220 m3/hr

328. Pump Second floor purified water

System W/MS/CP/045 CRI WR-130

09 m³/ HRS

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