PPT Nano Gold.cancer
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Transcript of PPT Nano Gold.cancer
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Antiangiogenic property of SwarnaBhasma (Nano gold particles) in Management of Cancer
Dr.C.Sobhana
HOD,Professor
Dr.G.Jai.
Professor
Yogesh Chavan
MD Scholar
Rasasastra Dept.
Govt.Ayu.College,
Tripunithura
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Introduction
• Cancer is an abnormal growth of cells in the body.
• highly complex disease.
• Modern medicine treat/control a majority of cancers, however a complete cure may not be possible.
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Ayurvedic Bhasma preparation
• most ancient but ultramodern forms of nanotechnology.
• particle size ranges from 10 to 100 nm
• “nano” means to one-billionth.
• nanometer is one-billionth of a meter.
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Cancer
• Mutated cells start duplicating (mitosis) themselves in an abnormal way.
• Metastasis – further cancer cell migrates & start spreading.
• Angiogenesis- formation of new blood vessels.
• Essential for the growth & progression of tumors.
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Drug delivery• Nanomedicine approaches to drug
delivery center on developing nanoscale particles or molecules to improve drug bioavailability.
• Drug delivery focuses on maximizing bioavailability both atspecific places in thebody and over a period of
time
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Process of Incineration of swarna
• Purified gold foil + mercury Rubbed in mortar.
• Add cinnabar, sulphur, realgar and ammonium chloride in equal proportion.
• Keep in Sharava & give Kukkuta puta.
• Colour – Brown red.
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Characterization of Swarnabhasma
• contains 92% gold by Atomic Absorption Spectroscopy.
• mercury is not detected.
• globular particles.
• average size of 56-57 nm.
• Classical dose =15mg -30mg
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Nano Gold Action mechanism
• Uptake in the small intestine by persorption
through single, degrading enterocytes.
• Reach various organs through blood.
• Reach the affected site even after oral
administration.
• Would act as a depot for the slow and sustained
release of Au ions required for therapeutic
action.
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Effect of nanogold on the proliferation of human umbilical vascular endothelial cells
• Research done at dept. Of biochemistry & molecular biology gugg. China.
• Whether nanogold had any effect on vascular endothelial growth factor 165- & vegf 121-induced human umbilical vascular endothelial cell proliferation.
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Results
• Nanogold inhibited VEGF165-induced proliferation of HUVE cells.
• Inhibited bFGF-induced proliferation but did not interfere with the activity of EGF.
• Proliferation of capillaries, blood supply to cancerous cell (angiogenesis) is arrested.
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Advantages of nano gold
• Reduces dosage.
• Ensures the pharmaceutical effects.
• Minimizes side-effects.
• Enhances drug stability.
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• Penetrate through small capillaries & taken up by
cells, which allows efficient drug accumulation at
target sites.
• A sustained and controlled release at target sites
over a period of days or even weeks is possible.
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Conclusion
• Uniform size of 57nm • Can penetrate through small capillaries & cell
linings • Attains concentration at target cells.• Sustained release source of nano gold particles • Inhibits signaling of VEGF 165 & angiogenesis.• Tumor is starved.• And growth of cancerous cells is prevented.• Without harming the normal cell/toxicity.
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•THANK YOU