Robert BolandTranslational Informatics & External Innovation13-Oct-2015

The Digital Patient: Innovation in Leveraging Digital Biomarker and Sensor Technology

1

Business Context

Janssen is engaged on a number of fronts in exploring opportunities to use commercially available and emerging technologies (chiefly biosensors and mobile technologies) to create new services, develop higher degrees of engagement with healthcare stakeholders and to improve effectiveness/ adherence of medicines. The nature of these engagements are decidedly cross-discipline, bringing together researchers, healthcare professionals, care-givers, technologists, human factors research, designers and the patients themselves to develop these solutions.

205/01/2023Digital Patient COP

Digital Patient Challenges

Collecting and making meaningful  assessments of streaming data Consumer Grade Data not good enough API’s are required to extract granular data

Disparate Devices and Manufacturer landscape as it relates to Health IT Many Devices Manufactures with ‘An App for That!”

Garmin Fitbit Apple Intel Google

How to evaluate and who’s to select? What JNJ is doing to accelerate the pace of Innovation the pace

related to the Digital Patient

305/01/2023Digital Patient COP

4

Health & wellnessEarly DiagnosticsInterceptionTherapy/ AdherenceRelapse Risk mitigation

Patient-Centric Care Continuum

5

Web / Mobile

Smart Packaging

Sensors

Digital Diagnostics

Behavior Tracking

Health & wellnessEarly DiagnosticsInterceptionTherapy/ AdherenceRelapse Risk mitigation

Digital Patient-Centric Care Continuum

Observational/Clinical TrialSymptom monitoring via sensors and

apps to support Clinical Trial compliance and data collection efforts

Pharma Development Process

Create

ConfirmIntegrate

ConsumerHelpful recommendations

and self-assessment tools to improve patient experience and

outcomes while generating “Real World” data to improve

product outcomes

ClinicalObjective measures via sensors, combines with

messaging and assessment tools to improve patient-HCP

communication and visibility of issues/ tracking outcomes

Explore

Information Technology 705/01/2023

Digital Patient Technology Use Cases

Qualification Study Is “this” digitally collected data better, faster or cheaper than an existing diagnostic?

Exploratory / POCIdentify what data can we obtain digitally, and what are the gaps/challenges to harness it.

Lower Development BarriersDevelopment of capabilities that can de-risk future trials with better data and better clinical end-points.

Rx SupportEvidence based methods to inform clinicians decision to start/change therapies.

Disease ManagementSolutions to provide patients and caregivers with better tools to manage their condition.

Disease InterceptionSolution to provide patients and caregivers with actionable information to prevent (or limit impact of) disease onset

Clinical Trial ExecutionCapabilities that allow digitally gathered data to serve as surrogate endpoints to accelerate trials.

AdherenceSolutions that measure adherence and provide feedback to patients, caregivers and HCPs

Subject SelectionCapabilities that create engagement, deliver digital assessments and allow digital patient data to be combined with other data (e.g. RWE) to identify and recruit target patients/subjects.

Observational/Clinical Trials Integrated Solutions Consumer Health

Self Directed HealthData and algorithms that provide insight to a patient (or their caregiver) on their current health status, presented with content and comparative data that allows the consumer to make better health decisions.

Mobile/Web Applications

Continuous Biosensor Monitoring

Objective Diagnostic Testing

Behavior Tracking

Smart Packaging

Digital Patient Technology Use Cases

Self-Administered Diagnostics &

Questionnaires Voice Analysis

Gaming / Gamification

Haptic Feedback

Blood Markers

Galvanic Skin Response

Weight / BMI

Sleep Quality / Duration

Texting / Email Frequency Social Media Location

Motion

Diary/Journal

Eye Tracking

Joint Range of Motion

Task Speed

EKG / EEG

Tracking / Serialization

Blister Pack Monitoring

Medicinal Bottle

Monitoring

2D/3D Image & Video Analysis

Blood Pressure

/Heartrate

Content Delivery

Repetitive behaviors

Alerts / Messaging

Electrochemical