Pistoia Alliance European Conference 2015 - Julia Wilson / Global Alliance for Genomics and Health
The Pistoia Alliance: Strategy, Progress, Momentum
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www.pistoiaalliance. org Ramesh Durvasula, PhD Director, Molecular Sciences & Candidate Optimization Informatics, Bristol-Myers Squibb BioITWorld Expo, Boston, April 2011 The Pistoia Alliance Strategy, Progress, Momentum
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Pistoia Alliance Board Member Ramesh Durvasula of BMS provides an overview of the Pistoia Alliance and project status at the BioITWorld Expo in Boston on April 13, 2011.
Transcript of The Pistoia Alliance: Strategy, Progress, Momentum
www.pistoiaalliance.org
Ramesh Durvasula, PhDDirector, Molecular Sciences & Candidate Optimization Informatics, Bristol-Myers Squibb
BioITWorld Expo, Boston, April 2011
The Pistoia AllianceStrategy, Progress, Momentum
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Agenda
• Industry Drivers• The Origins of Pistoia• The Mission and Strategy of
Pistoia• The Initiatives of Pistoia
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What is Core to your Business? What is Critical?
Core?
Cri
tical?
YES NO
NO
YES
FocusStaff on
Innovation
Externalize for Cost
Reduction
Externalizefor
Best Practices
ReduceNon-Value
Added Work
1990
2011
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The Mission of the Pistoia Alliance
Lowering the barriers to innovation
by improving the interoperability of R&D business processes
via pre-competitive collaborations
Pistoia MembershipFebruary2011
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Domains of Action
Biology & Translational Medicine
Chemistry
Scientific Collaboratio
n
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The Focus of Each Domain
Big Data, Analytics, Semantics
Supply Chain, Tech
Transfer
Vocabularies, Use
Cases, Best Practices
Biology Chemistry
Scientific Collaboration
2010-2013 2012-2014
2012+
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A Reality Check: Setting Expectations
VS.
VS.
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The Biology Domain
1.Sequence Services
2.SESL3.Biology Domain
Roadmap
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Sequence Services – the Rationale
“It takes all the running you can do, to keep in the same place!” -- Red Queen
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Put Sequence Services in the Cloud
Public Data, Private DataPublic Tools, Private ToolsConfigurable , Secure Access
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Sequence Services: Proofs-of-Concept
1. Cognizant & Eagle2. Constellation & Microsoft3. Infosys4. Thomson Reuters
4 proof-of-concept implementations were built
Sequence Services site
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The Biology Domain
1.Sequence Services
2.SESL3.Biology Domain
Roadmap
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SESL: Try this at your desk….
Which diseases are correlated to TCF7L2?
Gene/Protein Literature – Full TextLiterature - Abstracts
Inherited diseases Gene expression
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Try it again with Pistoia’s SESL….Gene naming/synonymsGene FunctionLiterature statisticsDisease co-occurrencesGene/protein interactions
…all in one report from one search
HOW? A standard ontology, data model, query language, report structure, etc.
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The Standards used within SESL
Category Name Community
Triple Store
RDF W3CSPARQL W3C
Jena, Sesame, Virtuoso Varied
Text Mining
leXML EBI & CALBC
LexEBI/BioLexicon EBI, NaCTeM, U of Pisa
CALCBC EBI & CALBC
URIs
UniProt EBI, PIR, SBI, etcDisease Ontology and
UMLS
ArrayExpress EBINCBI Taxonomy NCBI
RDF Schema
Dublin Core N3 notation W3C
Co-occurrence of gene-disease EBI
PMC doc standard NCBI
SESL-2 Relation ontology OBOURI server W3C
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The Deliverables of SESL
• A Proof-of-Concept to demonstrate feasibility and clarify requirements
• A functional specification for query brokering, result filtering, report generation
• A potential for a new Business Model
SESL website
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The Biology Domain
1.Sequence Services
2.SESL3.Biology Domain
Roadmap
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Breadth of Information Integrated (content)
Breadth of Information Integrated (content)
Com
ple
xity
of S
erv
ice-
En
ab
lem
en
tC
om
ple
xity
of S
erv
ice-
En
ab
lem
en
t
SESL
SequenceServices
Secure integrated multi-domain information
services
…
caBIG
SAGE
EATRIS
ELIXIR
Sequences
Expression
Scientific Literature
Biology Domain Roadmap
Large ScaleAnalytics
Multi-tenant
Security
Hosting &integration of private
data
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Our industry needs a Disruptive Innovation. That Disruption...is Pistoia
IF YOU WANT TO GO FAST, GO ALONEIF YOU WANT TO GO FAR, GO TOGETHER
Click to edit Master title styleThank you
This presentation: http://goo.gl/tVdpywww.pistoiaalliance.org
