Patients Treated with Leksell Gamma Knife ® 1968-2014.

Patients Treated with Leksell Gamma Knife®

1968-2014

2

• Global Statistics Slide Number

Cumulative volume3

Indications treated annually 4 2014 regional volume

5 Average regional volume

6 Global case mix by year

7 Cumulative regional case mix 8 2014 case mix

9 Cumulative case mix

10 Cumulative indications treated 11 Indications treated 2014

12 Case mix by country

13 Indications fractionated 2014 43

• Indication-Specific Statistics

Vascular Disorders16

Functional Disorders21

Ocular Disorders 26 Benign Tumors

30 Malignant Tumors

37

• Region & Country Statistics

Asia (excluding Japan) Cumulative volume

46 Indications treated annually 47 Cumulative case mix

48 Cumulative indications treated 49 2014 volume

50 China cumulative volume

51 China case mix

52 South Korea cumulative volume 53 South Korea case mix

54 Taiwan cumulative volume

55 Taiwan case mix

56

TABLE OF CONTENTS North America Cumulative volume



62 United States cumulative volume 63 United States case mix

64

Japan Cumulative volume



70

Latin America Cumulative volume



76

Europe Cumulative volume



82 Turkey cumulative volume

83 Turkey case mix

84 United Kingdom cumulative volume

85 United Kingdom case mix

86

Middle East & Africa Cumulative volume



92

• Please note that making detailed year over year comparisons is not advised due to the annual variability in number of centers reporting. The percent of centers reporting has ranged from 68% to 100%. The rate for 2014 is 95%.

• Data for specific countries is only provided for those countries with 7 or more Gamma Knives.

• The Society has increasingly improved the specificity of indication-specific reporting to allow for a more refined representation of clinical practice. For example, Essential Tremor treatments were reported within 'Other Functional Disorders' prior to 2012, but separately for the past three years.

• Please reference the Leksell Gamma Knife® Society when using or distributing the data in this presentation and do not hesitate to contact the Secretariat for any questions regarding the data.

CAVEATS

3

Leksell Gamma Knife®

OVER 884,000 PATIENTS TREATED THROUGH 2014, WORLDWIDE

68-100% centers reporting1991 reflects cumulative numbers

4


INDICATIONS TREATED ANNUALLY THROUGH 2014, WORLDWIDE


5


TOTAL NUMBER OF TREATMENTS BY REGION 2014

95% centers reporting

17.6321.070

21.536

2.950

12.448

18.608

6


AVERAGE NUMBER OF PERFEXION TREATMENTS PER REGION AND CENTER 2014

AVERAGE NUMBER OF TREATMENTS PER CENTER WORLDWIDE:

293

US: 183Canada: 316


7


GLOBAL CASE MIX BY YEAR

13%

27%

49%46

%38%

33%

36%34%

34%

40% 42% 45%48% 46

%45%

46%

46% 43

%

44%

43%

46%

45%

47% 43

%

44%

33%

31%38%

42% 41%42%

39%35%37%

34% 31% 33% 32% 33% 35% 35% 35% 35% 38% 39% 39% 39% 39% 40%51%

40%

27%22% 19% 18% 16% 14% 13% 12% 11% 11% 10% 11% 11% 11% 10% 10% 10% 11% 10% 10% 10% 10%

3% 1% 2%1%

2% 3%1%

4% 6% 8% 9% 8% 9% 9% 9% 9% 8% 8% 8% 8% 7%

1%7% 7% 7% 7% 7%


8


CASE MIX FOR 1991 – 2014 BY REGION

27%

16%

31%

15%

71%

7%

21%

30%

13%

15%

49%

7%

51%

5%

46%

6%

20%

2% 1%

41%

6% 1%

67%

4%

28%

16%


9


CASE MIX FOR 2014 BY REGION

29%

32%

76%

24% 17

%

57%

52%

49%

18%

47%

67%

25%

15%

11%

5%

19%

12% 4%

5%

6%

9%

5% 13

%

1%

1%

1%


10


TREATMENTS BY INDICATION 1991 – 2014, WORLDWIDE

325.009

386.895

3.317

64.995

103.991


11


INDICATIONS TREATED 1991 – 2014, WORLDWIDE

*Essential Tremor treatments reported as Other Functional Disorders prior to 2012

*


12


INDICATIONS TREATED 2014, WORLDWIDE


13


CASE MIX BY COUNTRY 2014

CHINA JAPAN SOUTH KOREA

2%


14



TAIWAN UNITED KINGDOM

2.2%


15



UNITED STATES TURKEY

2%


16


VASCULAR DISORDERS, CUMULATIVE PATIENTS TREATED WORLDWIDE


17


VASCULAR DISORDERS, CUMULATIVE PATIENTS TREATED WORLDWIDE

86.987

353

5.905

10.136

610


18


VASCULAR DISORDERS TREATED ANNUALLY, WORLDWIDE


19

5.352


VASCULAR DISORDERS, PATIENTS TREATED 2014 WORLDWIDE

1.393

268172

4

2.4%


20


ARTERIOVENOUS MALFORMATIONS, CUMULATIVE PATIENTS TREATED WORLDWIDE


21


FUNCTIONAL DISORDERS, CUMULATIVE PATIENTS TREATED WORLDWIDE


22


FUNCTIONAL DISORDERS, CUMULATIVE PATIENTS TREATED WORLDWIDE

56.617

2.824

2.110

1.531

787475

267105

8275

65

1823

103

*


2.4%


23


FUNCTIONAL DISORDERS TREATED ANNUALLY, WORLDWIDE

*



24


FUNCTIONAL DISORDERS, PATIENTS TREATED 2014 WORLDWIDE

4.468

195

1623834

3428

2721

126

14

2


25


TRIGEMINAL NEURALGIA, CUMULATIVE PATIENTS TREATED WORLDWIDE


26


OCULAR DISORDERS, CUMULATIVE PATIENTS TREATED WORLDWIDE


27


OCULAR DISORDERS, CUMULATIVE PATIENTS TREATED WORLDWIDE

350

321

2.646


28


OCULAR DISORDERS TREATED ANNUALLY, WORLDWIDE


29


OCULAR DISORDERS, PATIENTS TREATED 2014 WORLDWIDE

227

33

3


30


BENIGN TUMORS, CUMULATIVE PATIENTS TREATED WORLDWIDE


31


BENIGN TUMORS, CUMULATIVE PATIENTS TREATED WORLDWIDE

125.760

85.32463.692

9.189

8.277

6.254

5.5275.194

3.9123.341

3.3112.869

1.985

12090

164


1.9%

1.7%

32


BENIGN TUMORS TREATED ANNUALLY, WORLDWIDE


33


BENIGN TUMORS, PATIENTS TREATED 2014 WORLDWIDE

7.632

13.031

4.459

881

749

512422

396306

251237

164158

917045

1.7%


34


MENINGIOMA, CUMULATIVE PATIENTS TREATED WORLDWIDE


35


VESTIBULAR SCHWANNOMA, CUMULATIVE PATIENTS TREATED WORLDWIDE


36


PITUITARY ADENOMAS, CUMULATIVE PATIENTS TREATED WORLDWIDE


37


MALIGNANT TUMORS, CUMULATIVE PATIENTS TREATED WORLDWIDE


38


MALIGNANT TUMORS, CUMULATIVE PATIENTS TREATED WORLDWIDE

386.895

250334

1.0792.032

13.055

35.141


39


MALIGNANT TUMORS TREATED ANNUALLY, WORLDWIDE


40


MALIGNANT TUMORS, PATIENTS TREATED 2014 WORLDWIDE

29.405

3969

135184

985

1.530


41


METASTATIC TUMOR, CUMULATIVE PATIENTS TREATED WORLDWIDE


42


GLIAL TUMOR, CUMULATIVE PATIENTS TREATED WORLDWIDE


43


INDICATIONS FRACTIONATED 2014, USING THE LEKSELL FRAME OR WITH EXTEND™

40

210

362

51 centers reporting

44


INDICATIONS FRACTIONATED 2014, USING THE LEKSELL FRAME OR WITH EXTEND™

51 centers reporting

Asia excluding Japan1990 - 2014

PATIENTS TREATEDWITH LEKSELL GAMMA KNIFE®

46


OVER 235,000 PATIENTS TREATED THROUGH 2014ASIA (excluding Japan)


47


INDICATIONS TREATED ANNUALLYASIA (excluding Japan)


48


CASE MIX 1991 - 2014ASIA (excluding Japan)

355

12.412

39.02364.698

120.246


49


INDICATIONS TREATED 1991 – 2014, ASIA (excluding Japan)

*



50


CASE MIX 2014ASIA (excluding Japan)

21

1.120 11.103

3.127

6.165


51


OVER 157,000 PATIENTS TREATED THROUGH 2014CHINA


52


CASE MIX 1991 - 2014CHINA

9.129

82.592

42.368

289

23.362


53


OVER 42,000 PATIENTS TREATED THROUGH 2014SOUTH KOREA


54


CASE MIX 1991 - 2014SOUTH KOREA

16.302

17.991

50

7.326

1.216


55


OVER 13,000 PATIENTS TREATED THROUGH 2014TAIWAN

68-100% centers reporting

56


CASE MIX 1993 - 2014TAIWAN

1.055

3.034

12

6.549

2.981


57

North America1987 - 2014


58


OVER 225,000 PATIENTS TREATED THROUGH 2014NORTH AMERICA


59


INDICATIONS TREATED ANNUALLYNORTH AMERICA


60


CASE MIX 1991 - 2014NORTH AMERICA

63.547

35.604

16.703109.738

128


61


INDICATIONS TREATED 1991 – 2014, NORTH AMERICA

*



62


CASE MIX 2014NORTH AMERICA

4.444

2.372

766

10.03515


63


OVER 215,000 PATIENTS TREATED THROUGH 2014UNITED STATES


64


CASE MIX 1991 - 2014UNITED STATES

59.999

34.002

106.26015.813

107


65

Japan1990 - 2014


66


OVER 210,000 PATIENTS TREATED THROUGH 2014JAPAN


67


INDICATIONS TREATED ANNUALLYJAPAN


68


CASE MIX 1991 - 2014JAPAN

4.930

15.366

107

41.423

150.456

2.3%


69


INDICATIONS TREATED 1991 – 2014, JAPAN

*



70


CASE MIX 2014JAPAN

133

614

9

2.268

9.424


71

Latin America1985 - 2014


72


OVER 5,500 PATIENTS TREATED THROUGH 2014LATIN AMERICA


73


INDICATIONS TREATED ANNUALLYLATIN AMERICA


74


CASE MIX 1991 - 2014LATIN AMERICA

1.744

1.217

60

2.376

358


75


INDICATIONS TREATED 1991 – 2014, LATIN AMERICA

*



76


CASE MIX 2014LATIN AMERICA 261

205

8

498

98


77

Europe1968 - 2014


78


OVER 180,000 PATIENTS TREATED THROUGH 2014EUROPE


79


INDICATIONS TREATED ANNUALLYEUROPE


80


CASE MIX 1991 - 2014EUROPE

28.507

10.940

85.375

58.392

2.642


81


INDICATIONS TREATED 1991 – 2014, EUROPE

*



82


CASE MIX 2014EUROPE

2.128

1.178

9.129

5.968

205


83


OVER 22,000 PATIENTS TREATED THROUGH 2014TURKEY


84


CASE MIX 1997 - 2014TURKEY

492

5.059

72

12.419

4.218


85


OVER 22,000 PATIENTS TREATED THROUGH 2014UNITED KINGDOM


86


CASE MIX 1991 - 2014UNITED KINGDOM

1.186

7.829

302

9.934

3.364


87

Middle East & Africa1996 - 2014


88


OVER 17,000 PATIENTS TREATED THROUGH 2014MIDDLE EAST & AFRICA


89


INDICATIONS TREATED ANNUALLYMIDDLE EAST & AFRICA


90


CASE MIX 1996 - 2014MIDDLE EAST & AFRICA 2.648

2.394

2512.042

748


91


CUMULATIVE INDICATIONS 1996 – 2014, MIDDLE EAST & AFRICA

*

68-100% centers reporting*Essential Tremor treatments reported as Other Functional Disorders prior to 2012

92


CASE MIX 2014MIDDLE EAST & AFRICA 494

349

5

1.962

140


Patients Treated with Leksell Gamma Knife ® 1968-2014.

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Transcript of Patients Treated with Leksell Gamma Knife ® 1968-2014.