PATHOGENESIS
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Transcript of PATHOGENESIS
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PATHOGENESIS
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Shigella cause bacillary dysentery
There are two types of dysentery
They are : a) Amoebic dysentery
b) Bacillary dysentery
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AMOEBIC DYSENTERY BACILLARY DYSENTERY
Incubation period is long
Insidious onsetLocal abdominal tenderness
Moderate tenesmus
Fever absent
Short
Sudden onsetGeneralised
severe
present
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Stool consists of blood,mucus,necrotic cells&feacal matter
Frequency less
Volume copious
Blood,mucus,hardly any fecal matter
MoreSmall
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LAB DIAGNOSISAMOEBIC DYSENTERY BACILLARY
DYSENTERYMICROSCOPYFew pus cellsRBC agglutinated
Trophozoites present
Charcoat layden crystals present
NumerousDiscrete not agglutinated
AbsentAbsent
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Bacilli not demonstrated in stool culture
Mild leucocytosis in blood smear
Serum agglutination negative
Can be demonstrated
Marked leukocytosis
positive
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Source-infected human beingsMode of transmission
DirectFomitesWaterContaminated foodFliesIn young male homosexuals
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Minimum infective dose is low
Pathogenecity resemble that of EIEC
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MECHANISM OF ACTION. Bacilli infect the epithelial cells of villi in LI multiplication Inflammatory reaction with capillary thrombosis Necrosis of epithelial cells
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Sh.dysenteriae type 1 forms an exotoxin.
CONGO RED BINDING TEST.
VIRULENCE MARKERS ANTIGENS
Virulence test.
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CLINICAL MANIFESTATIONS
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Incubation period-1 to 7 days.
SYMPTOMSFrequent passage of loose scanty stools containing blood & mucus
Abdominal crampsTenesmusFever & vomiting
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In severe cases- bacteremiaCOMPLICATIONS.
ArthritisToxic neuritis ConjunctivitisParotitisHUS
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Severity ranges from mild diarrhoea to acute fulminating dysentery
The whole spectrum of infection is termed as SHIGELLOSIS.
Of 10,000 people ingested with Sh.flexneri
25% asymptomatic25% transient fever25%fever with watery diarrhoea25% typical dysentery
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EPIDEMIOLOGY
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Epidemics always accompanies wars,poverty,lack of sanitation.
Source-humansCasesLess often carriers
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ASYLUM DYSENTERY.In USA
North-Sh.sonneiSouth-Sh.flexneri.
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In INDIA ,all age groupsFlexneri 50-85%Dysentriae 8-25%Sonnei 2-24% Boydii 0-8%
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In recent years,suddenly Sh. Dysentriae became virulent epidemic form.
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LAB DIAGNOSIS.
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Diagnosis depends on isolating bacilli from feaces.. 1.SPECIMENS.
-fresh stool -rectal swab -ideal specimen -direct swab of an ulcer.
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2.TRANSPORT. Sach’s buffered glycerol saline.
3.DIRECT MICROSCOPY.Saline & Iodine preparations.4.CULTURE.MacConkey’s agarDCA
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5.COLONY MORPHOLOGY&STAINING
NLFGram negativeMotility6.BIOCHEMICAL REACTIONS.Urease,citrate,H2S,KCN-negative.7.SLIDE AGGLUTINATION
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TREATMENT
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Uncomplicated shigellosis-self limiting.
Dehydration has to be corrected in infants and children
Antibacterial treatment not indicatedIn severe cases-nalidixic acid,norfloxacin,other flouroquinolones.
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PREVENTIONGeneral prophylaxis.Chemoprophylaxis. Immunoprophylaxis.
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Thank you