Papillary thyroid cancer
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Transcript of Papillary thyroid cancer
Papillary Thyroid Cancer
M.A.Khachatryan
The anatomo-histological structure of Thyroid Gland
Characteristics of Papillary Thyroid Cancer
• 80% of TC
• Common in females
• Peak onset ages 30-50
• Follicular cell genesis
• Well-differentiated
• Minimally invasive
• Lymphogenic spread
Causes/ Risk Factors
• Family history/genetic defect maybe involved
• Radiation
• Men
• Older persons
AACE/AME/ETA Thyroid Nodule Guidelines, Endocr Pract.2010;16(Suppl1
Symptoms and Signs
• Few or no symptoms
• Small lump(nodule)
• Painless during palpation
Exams and Tests
• History
• Physical examination
• US
• FNA
• Thyroid function tests
PTC US Features
• Hypoechogenicity
• Inhomogeneous echo pattern
• Microcalcifications
• Absence of peripheral halo
• Irregular borders, blurred margins
• Often intranodular hypervascularity
• Regional lymphadenopathy
Cytology of PTC; Nuclear inclusion.
Primary treatment
• No prospective clinical trials have clearly determined the “best treatment” of patients with PTC
• Appropiate surgical planning
202 ENDOCRINE PRACTICE Vol. 7 No. 3 May/June 2001
Macroscopic pathology-photograph
Microscopic examination
Adjuvant Therapy
• Thyroid Hormone-suppresive therapy
• Radioiodine Remnant Ablation(131J)
202 ENDOCRINE PRACTICE Vol. 7 No. 3 May/June 2001
M.A.Khachatryan