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Non-MTC Patients CT<85.5 ng/L After PG test in MTC CT<13000 ng/L Comparison r r IL vs. LIA 0.756*** 0.880*** IL vs. PCT 0.378*** 0.380** IL vs. IRMA 0.527*** 0.933*** LIA vs.PCT 0.315*** 0.410** LIA vs. IRMA 0.487*** 0.889*** IRMA vs.PCT 0.752*** 0.452** Supplemental Table 2: Comparison of CT data (IL, LIA and IRMA) with PCT results (Kryptor): CT levels were below detection limit and 85.5 ng/L (LIA) in non MTC-patients (n=437); between detection limit and 107 ng/L (LIA) during pentagastrin (PG) testing in patients with chronic kidney disease (n=13); and between 18.2 and 10300 ng/L (LIA) in patients with known MTC (n=10). All three sampling time points of the PG test were used for the calculations. **p<0.01; ***p<0.001

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Non-MTC Patients

CT<85.5 ng/L

After PG test in MTC

CT<13000 ng/LComparison r r

IL vs. LIA 0.756*** 0.880***IL vs. PCT 0.378*** 0.380**IL vs. IRMA 0.527*** 0.933***LIA vs.PCT 0.315*** 0.410**

LIA vs. IRMA 0.487*** 0.889***IRMA vs.PCT 0.752*** 0.452**

Supplemental Table 2: Comparison of CT data (IL, LIA and IRMA) with PCT results (Kryptor): CT levels were below

detection limit and 85.5 ng/L (LIA) in non MTC-patients (n=437); between detection limit and 107 ng/L (LIA) during

pentagastrin (PG) testing in patients with chronic kidney disease (n=13); and between 18.2 and 10300 ng/L (LIA) in

patients with known MTC (n=10). All three sampling time points of the PG test were used for the calculations.

**p<0.01; ***p<0.001