P2.::’...norepinephrine from, 115 Glucocorticoid-deficient animals, circulatory ef-fects...
Transcript of P2.::’...norepinephrine from, 115 Glucocorticoid-deficient animals, circulatory ef-fects...
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INDEX
443
Volume 164, November-December 1968
17u.Acetoxy-6-dimethylaminomethyl-21-fiuoro -3-ethoxypregna-3,5-dien-20-one hydrochloride
(SC-17599), a steroid, analgetic activity andother pharmacologic properties of, 371
Acetylcholine, cholinergic inhibition of self.
stimulation behavior, 202effect on catecholamine release from perfused
cat adrenal gland, 115sensitivity of the isolated nictitating membrane
of the cat to, after various procedures andagents, 146
stimulation of prostatic secretion by, 312
Acids, barbiturate, and barbiturate salts, orallyadministered, a comparison of the effects onhuman psychomotor performance, 433
Adenosine triphosphate, complex formation ofprocaine and procaine amide with, 239
Adrenal gland, cat, perfused, effect of potassium,nicotine, pilocarpine and acetylcholine ondifferential secretion of epinephrine andnorepinephrine from, 115
Adrenergic receptor(s), alpha, effect of pro-pranolol on blockade of, 82
alpha, nature of, and the preferred conforma-tions of ephedrine isomers, 75
Aiion, J., see Bliss, E. L., 122
Albuquerque, E. X., Whitsel, B. L. and Smith,C. M., 191
Alkylammonium compounds, patterns of musclespindle afferent stimulation by, 191
Aminopyrine demethylase activity, after pheno-barbital treatment in adult male rats, livergrowth associated with induction of, 405
Analgetic activity, and other pharmacologicproperties of a steroid, 17a-acetoxy-6-dimethylaminomethyl - 21 - fluoro - 3 - ethoxy -
pregna-3,5-dien-20-one hydrochloride (SC-
17599), 371Anaphylaxis, accompanied by bronchospasm,
reduced by dexamethasone or hydrocortisone,302
Anderson, E. G., see Shibuya, T., 185
Antiarrhythmic activity, of the dextro- and levo-rotatory isomers of 4-(2-isopropylamino-1-hydroxyethyl) methanesulfonanilide (MJ
1999), 317Antimalarial effect, of chioroquine and dihydro-
quinine upon Plasmodium knowlesi, in vitrostudies of, 380
Antonio, A., see Corrado, A. P., 253Aqueous humor, increased outflow of, from the
eyes of rabbits twenty-four hours after
cervical sympathetic ganglionectomy, furtherstudies on the mechanism of, 280
Aramendla, P., see Kaumann, A. J., 326Argyris, T. S., 405Arnold, K., see Gerber, N., 232Aviado, D. M., see Carrillo, L. R., 302
see Dungan, K. W., 290Azcurra, J. M., see Sellinger, 0. Z., 212
Barbiturate salts, and barbiturate acids, orallyadministered, a comparison of the effects onhuman psychomotor performance, 433
Barr, C. F., see Polet, H., 380Behavior, self-stimulation, cholinergic inhibition
of, 202Belej , M. A., Papacostas, C. A., Sevy, R. W. and
Jackson, A. F., 342Benzothiadiazide, effect on the isolated toad
bladder, 348Benzothiadiazine compounds, as hyperglycemic
agents, structure-activity relationships of,421
Berndt, W. 0. and Grote, D., 223Biiary excretion, of probenecid and its glucuro-
nide, 387a,a’-Bis-(dimethylammoniumacetaldehyde dieth-
ylacetal) - p,p’ - diacetylbiphenyl bromide
(DMAE), antagonism of ganglionic stimu-lants by, 176
Bladder, toad, isolated, effect of a benzothiadia-zide on, 348
toad, isolated, effect of chlormerodrin on, 362Bliss, E. L., Aiion, J. and Zwanziger, J., 122Blockade, ganglionic, and gangliomo hyper-
polarization, by dimethyiphenylpiperazinium,effects of lithium on, 166
neuromuscular, in the cat, vasodilatation ofbrainstem origin suppressed by, 333
of alpha adrenergic receptors, effect of pro-
pranolol on, 82Borison, H. L., see Miranda, P. M. S., 333Brain, cat, circadian rhythm of norepinephrine
regionally in, relationship to environmental
lighting and regional diurnal variations inbrain serotonin, 135
rat, kinetics of H’-norepinephrine accumulationinto slices from different regions of, 90
rat, with stress, metabolism of norepinephrine,serotonin and dopamine in, 122
Brainstem, origin, vasodilatation of, suppressedby neuromuscular blockade in the cat, 333
Brazilian scorpion venom (Tityus serrulatus),
444 INDEX
an unusual sympathetic postganglionic stimu-lant, 253
Bronchodilator, agent, new, soterenol (MJ 1992),pharmacologic potency and selectivity of, 290
effects, of corticosteroids in the sensitized rabbit,mechanisms for, 302
Bronchospasm, accompanying anaphylaxis, re-duced by dexamethasone or hydrocortisone,302
Calcium, and norepinephrine, sensitivity of theguinea-pig pacemaker to, after pretreatment
with reserpine, 259ion, effect on frequency-force relationship in
cardiac muscle, 1
Canine prostatic secretion, stimulation of, byparasympathomimetic agents, 312
Cardiac changes, in acute tolerance to norepineph-rine infusions, 270
Cardiac glycosides, interaction with catechol-amines, effects on glycolysis and glycogenoly-sis in skeletal muscle, 22
six radiolabeled, uptake and binding by guinea-pig hearts and isolated sarcoplasmic reticu-mm, 10
Cardiac muscle, effect of calcium and sodium ionon frequency-force relationship in, 1
Carrillo, L. R. and Aviado, D. M., 302Catapres (ST 155), hypotensive drug, effect on
heart and peripheral circulation, 45Catecholamines, circulatory effects in gluco-
corticoid-deficient animals, 31effect of potassium, nicotine, piocarpine and
acetyicholine on release from perfused catadrenal gland, 115
interaction with cardiac glycosides, effects onglycolysis and glycogenolysis in skeletalmuscle, 22
Cells, mast, rat peritoneal, histamine releasefrom, inhibition by coichicine and potentia-tion by deuterium oxide, 158
Central nervous system, of the cat, distribution
of C14-sucrose and 1126-iodide in, after variousroutes of injection into the cerebrospinalfluid, 412
Cerebrospinal fluid, distribution of C’4-sucroseand I”5-iodide in the central nervous systemof the cat after various routes of injection into,412
Cervical sympathetic ganglionectomy, furtherstudies on the mechanism of the increasedoutflow of aqueous humor from the eyes ofrabbits twenty-four hours after, 280
Chiormerodrin, effect on the isolated toad bladder,362
Chloroquine, and dihydroquinine, in vitro studiesof their antimalarial effect upon Plasmodium
knotvtesi, 380
Cho, Y. W., see Dungan, K. W., 290Cholinergic inhibition, of self-stimulation be-
havior, 202Circadian rhythm, of norepinephrine regionally
in cat brain, relationship to environmentallighting and regional diurnal variations inbrain serotonin, 135
Circulation, effects of catecholamines and ouabainin glucocorticoid-deficient animals, 31
peripheral, effect of the hypotensive drug ST155 (Catapres) on, 45
Coichicine, inhibition of histamine release fromrat peritoneal mast cells, 158#{149}
Compound 48/80, inhibition by coichicine ofhistamine release induced by, 158
Conn, H. L., Jr., see Thyrum, P. T., 239Cord transection, chronic, influence on effects of
5-hydroxytryptophan, 1-tryptophan and par-gyline on spinal neuronal activity, 185
Coronary ligation, prevention of ventricularfibrillation induced by, 326
Corrado, A. P., Antonio, A. and Diniz, C. R., 253Cortex, rabbit kidney, accumulation of Cu.
dinitrophenol by slices of, 223Corticosteroids, in the sensitized rabbit, mecha-
nisms for the bronchodilator effects of, 302Corvelli, A., see Reis, D. J., 135Craig, C. R., 371Cueto, C., Jr. and Moran, N. C., 31Cutler, R. W. P., see Korobkin, R. K., 412
Datta, D. K., see Dutta, S., 10Denham, S., see Tsai, T. H., 146Deuterium oxide, potentiation of histamine
release from rat peritoneal mast cells, 158Dexamethasone, reducing bronchospasm as-
companying anaphylaxis, 302Dihydroquinine, and chloroquine, in vitro studies
of their antimalarial effect upon Plasmodiu,n
knowlesi, 380Dimethyiphenylpiperazinium, ganglionic hyper-
polarization and blockade by, effects oflithium on, 166
C’4-Dinitrophenol, accumulation of, by slices ofrabbit kidney cortex, 223
Diniz, C. R., see Corrado, A. P., 253
Diphenylliydantoin, metabolism, effect of di-phenyl-piperazine compounds and other
agents on, 232Diphenyl-piperazine compounds, and other
agents, effect on diphenylhydantoin, zoxazola.mine and hexobarbital metabolism, 232
Diurnal variations, in brain serotonin, relation-ship to circadian rhythm of norepinephrineregionally in cat brain, 135
DMAE (a,a’ - bis - (dimethylammoniumacetalde -
hyde diethylacetal) - p,p’ - diacetylbiphenyl
INDEX 445.
bromide), antagonism of ganglionic stimu-lants by, 176
Domino, E. F. and Olds, M. E., 202Dopamine, metabolism of, in rat brain with
stress, 122
Drug, hypotensive, ST 155 (Catapres), effect on
heart and peripheral circulation, 45metabolism, in hypothermia, uptake, excretion
and, of C14-procaine by the isolated, perfusedrat liver, 396
Dungan, K. W., Cho, Y. W., Gomoll, A. W.,Aviado, D. M. and Lish, P. M., 290
Dutta, S., Goswami, S., Datta, D. K., Lindower,J. 0. and Marks, B. H., 10
Ephedrine isomers, preferred conformations andthe nature of the alpha adrenergic receptor,75
Epinephrine, differential secretion of, from per-fused cat adrenal gland, effect of potassium,nicotine, pilocarpine and acetyicholine on, 115
Epstein, L. C. and Lasagna, L., 433Eyes, of rabbits, further studies on the mechanism
of the increased outflow of aqueous humorfrom, twenty-four hours after cervical sympa-thetic ganglionectomy, 280
Farah, A., see Teiger, D. G., 1
Fibrillation, ventricular, induced by coronaryligation, prevention of, 326
Fleming, W. W., see Westfall, D. P., 259
Ganglionectomy, cervical sympathetic, further
studies on the mechanism of the increasedoutflow of aqueous humor from the eyes ofrabbits twenty-four hours after, 280
Ganglionic blockade and hyperpolarization, bydimethyiphenylpiperazinium, effects of lith-ium on, 166
Ganglionic stimulants, antagonism of, by a,a’-
bis-(dimethylammoniumacetaldehyde dieth-
ylacetal) - p,p’ - diacetylbiphenyl bromide(DMAE), 176
Gerber, N. and Arnold, K., 232Gillespie, E., Levine, R. J. and Malawista, S. E.,
158Gland, perfused cat adrenal, effect of potassium,
nicotine, piocarpine and acetylcholine ondifferential secretion of epinephrine andnorepinephrine from, 115
Glucocorticoid-deficient animals, circulatory ef-fects of catecholamines and ouabain in, 31
Glucuronide, of probenecid, biliary excretion of,387
Glutamine synthetase, inhibitory effects, dis-sociation of the convulsant and, methioninesulfoximine seizures, 212
Glycogenolysis, in skeletal muscle, effects of
cardiac glycosides and their interaction withcatecholamines on, 22
Glycolysis, in skeletal muscle, effects of cardiac-glycosides and their interaction with cate-cholamines on, 22
Glycosides, cardiac, interaction with catechol-
amines, effects on glycolysis and glycogenoly-sis in skeletal muscle, 22
81X radiolabeled cardiac, uptake and bindingby guinea-pighearts and isolated sarcoplasmie
reticulum, 10G#{243}mez,B., see Miranda, P. M. S., 333
Gomez, H. J. and Yard, A. C., 270Gomoll, A. W., see Dungan, K. W., 290
Goswam�i, S., see Dutta, S., 10
Grant, A. M., 8ee Wales, J. K., 421Green, A. I., see Snyder, S. H., 90Grote, D., see Berndt, W. 0., 223Guarino, A. M. and Schanker, L. S., 387Guinea-pig hearts, uptake and binding . of six
radiolabeled cardiac glycosides by, 10pacemaker, sensitivity to norepinephrine and
calcium after pretreatment with reserpine,
259
Heart(s), effect of the hypotensive drug ST l5�
(Catapres) on, 45guinea-pig, uptake and binding of six radio-
labeled cardiac glycosides by, 10Hemicholinium analog, DMAE, and ganglionic
transmission, 176
Hendley, E. D., see Snyder, S. H., 90Hexobarbital, metabolism, effect of diphenyl-
piperazine compounds and other agents on,232
Histamine, release from rat peritoneal mast cells,inhibition by colchicine and potentiation bydeuterium oxide, 158
Horita, A., see Yamamura, H. I., 82Humor, aqueous, increased outflow of, from the
eyes of rabbits twenty-four hours after
cervical sympathetic ganglionectomy, further
studies on the mechanism of, 280
Hydrocortisone, reducing bronchospasm as-companying anaphylaxis, 302
5-Hydroxytryptophan, effects on spinal neuronat
activity, influence of chronic cord transectiom
on, 185Hyperglycemic agents, structure-activity rela-
tionships of benzothiadiazine compounds as,421
Hyperpolarization, ganglionic, and ganglionie
blockade, by dimethyiphenylpiperasinium,
effects of lithium on, 166Hypothermia, drug metabolism in, and uptake
and excretion of C’4-procaine by the isolated,
perfused rat liver, 396
446 INDEX
i�.iodide, and C14-sucrose, distribution of, in the
central nervous system of the cat after various� - ..� � routes of injection into the cerebrospinal� . fluid,412
Ion, calcium and sodium, effect on frequency-� . � fos�ce relationship in cardiac muscle, 1
Isomers, dextro- and levo-rotatory, 4-(2-isopropyl-amino-1-hydroxyethyl) methanesulfonaniide
� .� � � ��MJ 1999), antiarrhythmic activity of, 317� � .ephedrine, preferred conformations and the
nature of the alpha adrenergic receptor, 754-(2-Isopropylamino-1-hydroxyethyl) methane-
sulfonaniide (MJ 1999), antiarrhythmicactivity of the dextro- and levo-rotatoryisomers of, 317
Jackson, A. F., see Belej, M. A., 342Jaramillo, J. and Volle, R. L., 166
Kals#{232}t-,S. C., Kelvington, E. J., Kunig, R. andRandolph, M. M., 396
1�, �. �., �ee Lipsius, M. R., 60
1<autnann, A. J. and Aramendfa, P., 326Kelvington, E. J., see Kaiser, S. C., 396�i�dney cortex, rabbit, accumulation of C’4-
dinitrophenol by slices of, 223Ki#{231}r,L.B., 75
Kinetics, of fl.norepinep�ine accumulation intoslices from different regions of rat brain, 90
Korobkin, It. K., Lorenzo, A. V. and Cutler, R.W. P., 412
Krees, �. V.., see Wales, J. K., 421� see.Kalser, S. C., 396
KSrpson, �:, Triner, L. and Nahas, G. G., 22
Lasagna, L., see Epstein, L. C., 433Levine, R. J., see Gillespie, E., 158
Ligation, coronary, prevention of ventricular:. �flbrillation induced by, 326
Lighting, environmental, in brain serotonin, re-
�. � Lat,io�iahip to circadian rhythm of norepineph-rine regionally in cat brain, 135
Ljndower., J.. 0., see Dutta, S., 10Lipsius, M. R., Siegman, M. J. and Kao, C. Y., 60jA�h,1�.M.,see Dungan, K. W., 290�ithi�n, #{149}effects on ganglionic hyperpolarization
and blockade by dimethyiphenylpiperazinium,
166Li�v�r, �#{149}growth associated with induction of
. aminbpyrine demethylase activity after
phenobarbital treatment in adult male rats,. � � �405#{149}’���#{149}
�rat, is#{246}l#{225}ted,perfused, uptake, metabolism andexcretion of C’4-procaine by, in hypothermia,
. .. -P396 � �Long, J� P.,see Wong, S., 176Lorenzo, A. V., see Korobkin, R. K., 412
Lowe, T. E., see Nayler, W. G., 45Luchi, R. J., see Thyrum, P. T., 239
Malawista, S. E., see Gillespie, E., 158Marks, B. H., see Dutta, S., 10Mast cells, rat peritoneal, histamine release from,
inhibition by coichicine and potentiation bydeuterium oxide, 158
McGrath, W. R., see Thai, T. H., 146Mclnnes, I., see Nayler, W. G., 45Membrane, isolated nictitating, of the cat,
sensitivity to norepinephrine and acetyl-choline after various procedures and agents,146
Metabolism, diphenylhydantoin, zoxazolamineand hexobarbital, effect of diphenyl-pipera-zinc compounds and other agents on, 232
muscle, effects of cardiac glycosides and theirinteraction with catecholamines on glycolysis
and glycogenolysis in, 22norepinephrine, serotonin and dopamine in rat
brain with stress, 122uptake and excretion, of C’4-procaine by the
isolated, perfused rat liver, in hypothermia,396
Methacholine, stimulation of prostatic secretionby, 312
i�-Methionine, antagonism of methionine sulfoxi-mine seizures, 212
Methionine sulfoximine, seizures, dissociation ofthe convulsant and glutamine synthetaseinhibitory effects, 212
Miele, E., see Rubin, R. P., 115Miranda, P. M. S., G#{243}mez,B. and Borison, H. L.,
333MJ 1992 (soterenol), a new bronchodilator agent,
pharmacologic potency and selectivity of,290
MJ 1999 [4-(2. isopropylamino - 1 -hydroxyethyl)methanesulfonaniide], antiarrhythmic as-tivity of the dextro- and levo-rotatory isomersof, 317
Molecular conformations, preferred, of ephedrine
isomers, and the nature of the alpha adrenergic
receptor, 75Moran, N. C., see Cueto, C., Jr., 31Muscle, cardiac, effect of calcium and sodium ion
on frequencg-force relationship in, 1patterns from spindle afferent stimulation by
alkylammonium compounds, 191skeletal, glycolysis and glycogenolysis in, effects
of cardiac glycosides and their interactionwith catecholamises on, 22
vascular smooth, direct relaxant actions ofprocaine and tetrodotoxin on, 60
Musculoskeletal system, effects of cardiac gly-cosides and their interaction with catechol-amines on glycolysis and glycogenolysis in, 22
INDEX 447
Nahas, G. G., see Kypson, J., 22Nayler, W. G., Price, J. M., Swann, J. B., Mclnnes,
I.,Race,D.andLowe,T.E.,45
Neostigmine, stimulation of prostatic secretionby, 312
Nerve stimulation, regulatory effect of puromycinon accelerated norepinephrine synthesis
associated with, 103Nervous system, central, of the cat, distribution
of C’4.sucrose and 1125-iodide in, after variousroutes of injection into the cerebrospinal
fluid, 412
Neuromuscular blockade, in the cat, vasodiata-tion of brainstem origin suppressed by, 333
Neuronal activity, spinal, influence of chroniccord transection on effects of 5-hydroxy-tryptophan, 1-tryptophan and pargyline on,
185
Nicotine, effect on catecholamine release fromperfused cat adrenal gland, 115
ganglionic stimulation and blockade by DMAE,176
reversal, in phenoxybenzamine-treatcd dogs,mechanism of, 342
Nictitating membrane, isolated, of the cat,sensitivity to norepinephrine and acetyl-choline after various procedures and agents,146
Norepinephrine, and calcium, sensitivity of theguinea-pig pacemaker to, after pretreatmentwith reserpine, 259
circadian rhythm of, regionally in cat brain,relationship to environmental lighting andregional diurnal variations in brain serotonin,135
differential secretion of, from perfused catadrenal gland, effect of potassium, nicotine,
piocarpine and acetyicholine on, 115infusions, cardiac and vascular changes in
acute tolerance to, 270metabolism of, in rat brain with stress, 122sensitivity of the isolated nictitating membrane
of the cat to, after various procedures andagents, 146
synthesis, accelerated, associated with nervestimulation, regulation of, effect of puromycinon, 103
H5-Norepinephrine, kinetics of, accumulation into
slices from different regions of rat brain,
90
Ohisson, W. G., see Sellinger, 0. Z., 212
Olds, M. E., see Domino, E. F., 202Ouabain, circulatory effects in glucocorticoid-
deficient animals, 31Outflow, increased, of aqueous humor from the
eyes of rabbits twenty-four hours after
cervical sympathetic ganglionectomy, furtherstudies on the mechanism of, 280
Oxotremorine, stimulation of prostatic secruti�mby, 312 . � .:
Pacemaker, guinea-pig, sensitivity to. norepineph-rine and calcium after. pretreatment � withreserpine, 259
Papacostas, C. A., see Belej, M. A., 342Parasympathomimetic agents, stimulation of
canine prostatic secretion by, 312 � -.
Pargyline, effects on spinal neuronal activity,influence of chronic cord transection on, 18&#{149}
Pendleton, R. G., Sullivan, L. P. and Tucker, J.M.,362 �
Sullivan, L. P., Tucker, J. M. and Stephenaon,R. E., III, 348
Peritoneal mast cells, rat, histamine release from,inhibition by colchicine and potentiation bydeuterium oxide, 158
Phenobarbital, a comparison of the effects ofbarbiturate salts and barbiturate acids onhuman psychomotor performance, 433
treatment in adult male rats, liver growthassociated with induction of aminopyrine
demethylase activity after, 405 .
Phenoxybenzamine-treated dogs, mechanisni ofnicotine reversal in, 342 . . � �:
Physostigmine, stimulation of prostatic secretionby,312
Piocarpine, effect on catecholamine release fromperfused cat adrenal gland, 115
stimulation of prostatic secretion by, 312Placebo, a comparison of the effects of barbiturate
salts and barbiturate acids on human psycho-motor performance, 433 :
Plasmodium knowlesi, in vitro studies of theantimalarial effect of chioroquine and di-hydroquinine upon, 380 .
Polet, H. and Barr, C. F., 380
Postganglionic stimulant, an unusual sym-pathetic, Brazilian scorpion venom (Tityus
serrulatus) , 253Potassium, effect on catecholamine release from
perfused cat adrenal gland, 115 �Price, J. M., see Nayler, W. G., 45Probenecid, and its glucuronide, biiary excretion
of,387 .
Procaine, and procaine amide, complex formationof, with adenosine triphosphate, 239
direct relaxant actions on vascular smoothmuscle, 60 . -
C’4-Procaine, uptake, metabolism and excretion of,by the isolated, perfused rat liver, in hy-pothermia, 396
Procaine amide, and procaine, complex formation
of, with adenosine triphosphate, 239 : -
448 INDEX
Propranolol, effect on blockade of alpha adrenergic
receptors, 82
Prostatic secretion, canine, stimulation of, byparasympathomimetic agents, 312
Psychomotor performance, human, a comparisonof the effects of orally administered bar-biturate salts and barbiturate acids on, 433
Puromycin, regulatory effect on acceleratednorepinephrine synthesis associated withnerve stimulation, 103
Itabadjija, M., see Weiner, N., 103Race, D., 885 Nayler, W. G., 45
Randolph, M. M., see Kalser, S. C., 396
Receptor(s), alpha adrenergic, effect of pro-pranolol on blockade of, 82
alpha adrenergic, nature of, and the preferredconformations of ephedrine isomers, 75
Reis, D. J., Weinbren, M. and Corvelli, A., 135Reserpine, sensitivity of the guinea-pig pace-
maker to norepinephrine and calcium afterpretreatment with, 259
Reticulum, isolated sarcoplasmic, uptake andbinding of six radiolabeled cardiac glycosidesby, 10
Reversal, nicotine, in phenoxybenzamine-treateddogs, mechanism of, 342
Rosser,M.J.andSears,M.L., 280
Rotatory isomers, dextro- and levo-, 4-(2-isopropyl-amino-1-hydroxyethyl) methanesulfonaniide(MJ 1999), antiarrhythmic activity of, 317
Rubin, R. P. and Miele, E., 115
Salts, barbiturate, and barbiturate acids, orallyadministered, a comparison of the effects on
human psychomotor performance, 433Sarcoplasinic reticulum, isolated, uptake and
binding of six radiolabeled cardiac glycosidesby, 10
SC-17599 (17a-acetoxy-6-dimethylazninomethyl-21-fluoro-3-ethoxypregna-3,5-dien-20-one hy-drochloride), a steroid, analgetic activity andother pharmacologic properties of, 371
Schanker, L. S., see Guarino, A. M., 387Sears, M. L., see Rosser, M. J., 280Secobarbital, a comparison of the effects of bar-
biturate salts and barbiturate acids on human. psychomotor performance, 433
Secretion, differential, of epinephrine and nor-
epinephrine from perfused cat adrenal gland,effect of potassium, nicotine, piocarpine andacetylcholine on, 115
Seizures, methionine sulfoximine, dissociation ofthe convulsant and glutamine synthetase in-hibitory effects, 212
Sellinger, 0. Z., Azcurra, J. M. and Ohisson, W.G., 212
Serotonin, brain, regional diurnal variations in,
effect of circadian rhythm of norepinephrine
regionally, relationship to environmentallighting and to, 135
metabolism of, in rat brain with stress, 122Sexy, R. W., See Belej, M. A., 342
Shibuya, T. and Anderson, E. G., 185
Siegman, M. J., 865 Lipsius, M. R., 60
Skeletal muscle, glycolysis and glytogenolysis in,effects of cardiac glycosidea and their inter-action with catecholamines on, 22
Smith, C. M., see Albuquerque, E. X., 191Smith, E. R., 312Smooth muscle, vascular, direct relaxant actions
of procaine and tetrodotoxin on, 60Snyder, S. H., Green, A. I. and Hendley, E. D., 90Sodium ion, effect on frequency-force relationship
in cardiac muscle, 1Somani, P. and Watson, D. L., 317Soterenol (MJ 1992), a new bronchodilator agent,
pharmacologic potency and selectivity of, 290Spinal cord, influence of chronic transection on
effects of 5-hydroxytryptophan, t-tryptophanand pargyline on spinal neuronal activity, 185
ST 155 (Catapres), hypotensive drug, effect onheart and peripheral circulation, 45
Stephenson, R. E., III, see Pendleton, R. G., 348Steroid, 17a-acetoxy-6-dimethylaminomethyl-21-
fluoro-3-ethoxypregna-3,5-dien-20.one hydro-
chloride (SC-17599), analgetic activity and
other pharmacologic properties of, 371Stimulant, an unusual sympathetic poetgangli-
onic, Brazilian scorpion venom (T#{252}yus aerru-
Lotus), 253
C14-Sucrose, and 1111-iodide, distribution of, in thecentral nervous system of the cat after variousroutes of injection into the cerebrospinalfluid, 412
Sullivan, L. P., see Pendleton, R. G., 348, 362Swarm, J. B., 865 Nayler, W. G., 45Sympathetic ganglionectomy, cervical, further
studies on the mechanism of the increased out-flow of aqueous humor from the eyes of rabbitstwenty-four hours after, 280
Sympathetic postganglionic stimulant, an un.usual, Brazilian scorpion venom (Tityus serru-talus), 253
Synthesis, norepinephrine, accelerated, associatedwith nerve stimulation, regulation of, effect
of puromycin on, 103
Synthetase, glutamine, inhibitoryeffects, dissocia-tion of the convulsant and, methionine sul-foximine seizures, 212
Teiger, D. G. and Farah, A., 1Tetrodotoxin, direct relaxant actions on vascular
smooth muscle, 60Thyrum, P. T., Luchi, R. J. and Conn, H. L., Jr.,
239
INDEX
Tityus serr-uiatus (Brazilian scorpion venom), anunusual sympathetic postganglionic stimu-lant, 253
Toad bladder, isolated, effect of a benzothiadia-zide on, 348
isolated, effect of chiormerodrin on, 362Triner, L., see Kypson, J., 22l-Tryptophan, effects on spinal neuronal activity,
influence of chronic cord transection on, 185Tsai, T. H., Denham, S. and McGrath, W. R., 146Tucker, J. M., see Pendleton, R. G., 348, 362
Vascular changes, in acute tolerance to norepi-nephrine infusions, 270
Vascular smooth muscle, direct relaxant actionsof procaine and tetrodotoxin on, 60
Vasodilatation, of brainstem origin, suppressedby neuromuscular blockade in the cat, 333
Venom, Brazilian scorpion (Tityus serrutatus), anunusual sympathetic postganglionic stimu-
lant, 253
449
Ventricular fibrillation, induced by coronaryligation, prevention of, 326
Viktora, J. K., see Wales, J. K., 421Voile, R. L., see Jaramillo, J., 166
Wales, J. K., Krees, S. V., Grant, A. M., Viktora,J. K. and Wolff, F. W., 421
Watson, D. L., see Somani, P., 317Weinbren, M., see Reis, D. J., 135
Weiner, N. and Rabadjija, M., 103Westfall, D. P. and Fleming, W. W., 259Whited, B. L., see Albuquerque, E. X., 191Wolff, F. W., see Wales, J. K., 421
Wong, S. and Long, J. P., 176
Yamamura, H. I. and Horita, A., 82Yard, A. C., see Gomez, H. J., 270
Zoxazolamine, metabolism, effect of diphenyl-
piperazine compounds and other agents on, 232Zwanziger, J., see Bliss, E. L., 122