P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … fileSpecies/Strain: RATS/SD Lab: BAT DAY ON TEST 0 2 1...

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TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008 Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56 Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04 Species/Strain: RATS/SD Lab: BAT 31 Wk_SSAC_R8 C Number: C20304 Lock Date: 10/12/2006 Cage Range: ALL Date Range: ALL Reasons For Removal: 25017 SSAC Removal Date Range: 27-Oct-2004 - 27-Oct-2004 Treatment Groups: Include 001 0 UG/KG Include 002 10 UG/KG Include 003 30 UG/KG Include 004 100 UG/KG Include 005 220 UG/KG Include 006 460 UG/KG Include 007 1000 UG/KG Include 008 4600 UG/KG Study Gender: Female TDMSE Version: 2.0.0

Transcript of P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … fileSpecies/Strain: RATS/SD Lab: BAT DAY ON TEST 0 2 1...

Page 1: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … fileSpecies/Strain: RATS/SD Lab: BAT DAY ON TEST 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1

TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008

Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56

Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04

Species/Strain: RATS/SD Lab: BAT

31 Wk_SSAC_R8

C Number: C20304

Lock Date: 10/12/2006

Cage Range: ALL

Date Range: ALL

Reasons For Removal: 25017 SSAC

Removal Date Range: 27-Oct-2004 - 27-Oct-2004

Treatment Groups: Include 001 0 UG/KG Include 002 10 UG/KG Include 003 30 UG/KG

Include 004 100 UG/KG Include 005 220 UG/KG Include 006 460 UG/KG

Include 007 1000 UG/KG Include 008 4600 UG/KG

Study Gender: Female

TDMSE Version: 2.0.0

Page 2: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … fileSpecies/Strain: RATS/SD Lab: BAT DAY ON TEST 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1

ALIMENTARY SYSTEM.........................................................................................................................................................................................................

Liver + + + + + + + + + + 10Clear Cell Focus X X 2Inflammation 1 1 1 1 1 1 1 1 1 1 10 1.0Bile Duct, Fibrosis 1 1 1.0

.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + 10Inflammation, Chronic Active 1 1 1.0

.........................................................................................................................................................................................................

Stomach, Forestomach + + + + + + + + + + 10.........................................................................................................................................................................................................

Stomach, Glandular + + + + + + + + + + 10

CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................

Blood Vessel + 1

ENDOCRINE SYSTEM.........................................................................................................................................................................................................

Adrenal Cortex + + + + + + + + + + 10Hyperplasia 1 1 1.0Hypertrophy 1 1 2 1.0

.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + 10

TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008

Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56

Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04

Species/Strain: RATS/SD Lab: BAT

DAY ON TEST0216

0216

0216

0216

0216

0216

0216

0216

0216

0216

.................................................................................................................................................................

SPRAGUE-DAWLEY RATSFEMALE

ANIMAL ID0 UG/KG

00061

00062

00063

00064

00065

00071

00072

00073

00074

00075 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 2

Page 3: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … fileSpecies/Strain: RATS/SD Lab: BAT DAY ON TEST 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1

.........................................................................................................................................................................................................

Pituitary Gland + + + + + + + + + + 10.........................................................................................................................................................................................................

Thyroid Gland + + + + + + + + + + 10Follicular Cell, Hypertrophy 2 1 2.0

GENERAL BODY SYSTEMNONE

GENITAL SYSTEM.........................................................................................................................................................................................................

Ovary + + + + + + + + + + 10.........................................................................................................................................................................................................

Uterus + + + + + + + + + + 10Inflammation 2 1 2.0Metaplasia, Squamous 1 1 1 1 4 1.0Endometrium, Hyperplasia, Cystic 1 1 1.0

.........................................................................................................................................................................................................

Vagina + + + + + + + + + + 10

HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................

Spleen + + + + + + + + + + 10Pigmentation 1 1 1 1 1 1 1 1 2 1 10 1.1

.........................................................................................................................................................................................................

TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008

Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56

Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04

Species/Strain: RATS/SD Lab: BAT

DAY ON TEST0216

0216

0216

0216

0216

0216

0216

0216

0216

0216

.................................................................................................................................................................

SPRAGUE-DAWLEY RATSFEMALE

ANIMAL ID0 UG/KG

00061

00062

00063

00064

00065

00071

00072

00073

00074

00075 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 3

Page 4: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … fileSpecies/Strain: RATS/SD Lab: BAT DAY ON TEST 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1

Thymus + + + + + + + + + + 10

INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................

Mammary Gland + + + + + + + + + + 10

MUSCULOSKELETAL SYSTEMNONE

NERVOUS SYSTEMNONE

RESPIRATORY SYSTEM.........................................................................................................................................................................................................

Lung + + + + + + + + + + 10Inflammation 1 1 1.0Alveolus, Infiltration Cellular, Histiocyte 1 1 1 1 4 1.0

SPECIAL SENSES SYSTEMNONE

URINARY SYSTEMNONE

TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008

Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56

Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04

Species/Strain: RATS/SD Lab: BAT

DAY ON TEST0216

0216

0216

0216

0216

0216

0216

0216

0216

0216

.................................................................................................................................................................

SPRAGUE-DAWLEY RATSFEMALE

ANIMAL ID0 UG/KG

00061

00062

00063

00064

00065

00071

00072

00073

00074

00075 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 4

Page 5: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … fileSpecies/Strain: RATS/SD Lab: BAT DAY ON TEST 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1

ALIMENTARY SYSTEM.........................................................................................................................................................................................................

Liver + + + + + + + + + + 10Clear Cell Focus X X X 3Inflammation 1 1 1 1 1 1 1 1 1 1 10 1.0

.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + 10

CARDIOVASCULAR SYSTEMNONE

ENDOCRINE SYSTEM.........................................................................................................................................................................................................

Adrenal Cortex + + + + + + + + + + 10.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + 10.........................................................................................................................................................................................................

Thyroid Gland + + + + + + + + + + 10

GENERAL BODY SYSTEMNONE

GENITAL SYSTEM.........................................................................................................................................................................................................

TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008

Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56

Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04

Species/Strain: RATS/SD Lab: BAT

DAY ON TEST0216

0216

0216

0216

0216

0216

0216

0216

0216

0216

.................................................................................................................................................................

SPRAGUE-DAWLEY RATSFEMALE

ANIMAL ID10 UG/KG

00111

00112

00113

00114

00115

00126

00127

00128

00129

00130 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 5

Page 6: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … fileSpecies/Strain: RATS/SD Lab: BAT DAY ON TEST 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1

Uterus + + + + + + + + + + 10Dilatation 3 4 2 3.5Inflammation, Suppurative 1 1 1.0Metaplasia, Squamous 1 1 1 3 1.0

HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................

Thymus + + + + + + + + + + 10Atrophy 2 1 2.0

INTEGUMENTARY SYSTEMNONE

MUSCULOSKELETAL SYSTEMNONE

NERVOUS SYSTEMNONE

RESPIRATORY SYSTEM.........................................................................................................................................................................................................

Lung + + + + + + + + + + 10Alveolus, Infiltration Cellular, Histiocyte 1 1 1.0

TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008

Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56

Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04

Species/Strain: RATS/SD Lab: BAT

DAY ON TEST0216

0216

0216

0216

0216

0216

0216

0216

0216

0216

.................................................................................................................................................................

SPRAGUE-DAWLEY RATSFEMALE

ANIMAL ID10 UG/KG

00111

00112

00113

00114

00115

00126

00127

00128

00129

00130 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 6

Page 7: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … fileSpecies/Strain: RATS/SD Lab: BAT DAY ON TEST 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1

SPECIAL SENSES SYSTEMNONE

URINARY SYSTEMNONE

TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008

Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56

Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04

Species/Strain: RATS/SD Lab: BAT

DAY ON TEST0216

0216

0216

0216

0216

0216

0216

0216

0216

0216

.................................................................................................................................................................

SPRAGUE-DAWLEY RATSFEMALE

ANIMAL ID10 UG/KG

00111

00112

00113

00114

00115

00126

00127

00128

00129

00130 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 7

Page 8: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … fileSpecies/Strain: RATS/SD Lab: BAT DAY ON TEST 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1

ALIMENTARY SYSTEM.........................................................................................................................................................................................................

Liver + + + + + + + + + + 10Clear Cell Focus X X X X 4Inflammation 1 1 1 1 1 1 1 1 1 1 10 1.0Mixed Cell Focus X 1Hepatocyte, Hypertrophy 1 1 1.0

.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + 10

CARDIOVASCULAR SYSTEMNONE

ENDOCRINE SYSTEM.........................................................................................................................................................................................................

Adrenal Cortex + + + + + + + + + + 10Hypertrophy 1 1 1.0

.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + 10.........................................................................................................................................................................................................

Thyroid Gland + + + + + + + + + + 10

GENERAL BODY SYSTEMNONE

TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008

Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56

Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04

Species/Strain: RATS/SD Lab: BAT

DAY ON TEST0216

0216

0216

0216

0216

0216

0216

0216

0216

0216

.................................................................................................................................................................

SPRAGUE-DAWLEY RATSFEMALE

ANIMAL ID30 UG/KG

00201

00202

00203

00204

00205

00216

00217

00218

00219

00220 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 8

Page 9: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … fileSpecies/Strain: RATS/SD Lab: BAT DAY ON TEST 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1

GENITAL SYSTEM.........................................................................................................................................................................................................

Uterus + + + + + + + + + + 10Metaplasia, Squamous 1 1 2 1.0Endometrium, Hyperplasia, Cystic 1 1 2 1.0

HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................

Thymus + + + + + + + + + + 10Atrophy 2 1 2.0

INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................

Mammary Gland + 1

MUSCULOSKELETAL SYSTEMNONE

NERVOUS SYSTEMNONE

RESPIRATORY SYSTEM.........................................................................................................................................................................................................

Lung + + + + + + + + + + 10

TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008

Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56

Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04

Species/Strain: RATS/SD Lab: BAT

DAY ON TEST0216

0216

0216

0216

0216

0216

0216

0216

0216

0216

.................................................................................................................................................................

SPRAGUE-DAWLEY RATSFEMALE

ANIMAL ID30 UG/KG

00201

00202

00203

00204

00205

00216

00217

00218

00219

00220 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 9

Page 10: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … fileSpecies/Strain: RATS/SD Lab: BAT DAY ON TEST 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1

Inflammation 1 1 1.0

SPECIAL SENSES SYSTEMNONE

URINARY SYSTEMNONE

TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008

Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56

Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04

Species/Strain: RATS/SD Lab: BAT

DAY ON TEST0216

0216

0216

0216

0216

0216

0216

0216

0216

0216

.................................................................................................................................................................

SPRAGUE-DAWLEY RATSFEMALE

ANIMAL ID30 UG/KG

00201

00202

00203

00204

00205

00216

00217

00218

00219

00220 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 10

Page 11: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … fileSpecies/Strain: RATS/SD Lab: BAT DAY ON TEST 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1

ALIMENTARY SYSTEM.........................................................................................................................................................................................................

Liver + + + + + + + + + + 10Inflammation 1 1 1 1 1 1 1 1 1 1 10 1.0Hepatocyte, Hypertrophy 1 1 1.0

.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + 10

CARDIOVASCULAR SYSTEMNONE

ENDOCRINE SYSTEM.........................................................................................................................................................................................................

Adrenal Cortex + + + + + + + + + + 10Hyperplasia 1 1 1.0Hypertrophy 1 1 1.0

.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + 10.........................................................................................................................................................................................................

Thyroid Gland + + + + + + + + + + 10

GENERAL BODY SYSTEMNONE

TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008

Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56

Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04

Species/Strain: RATS/SD Lab: BAT

DAY ON TEST0216

0216

0216

0216

0216

0216

0216

0216

0216

0216

.................................................................................................................................................................

SPRAGUE-DAWLEY RATSFEMALE

ANIMAL ID100 UG/KG

00361

00362

00363

00364

00365

00376

00377

00378

00379

00380 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 11

Page 12: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … fileSpecies/Strain: RATS/SD Lab: BAT DAY ON TEST 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1

GENITAL SYSTEM.........................................................................................................................................................................................................

Uterus + + + + + + + + + + 10Inflammation, Suppurative 1 1 1.0Metaplasia, Squamous 1 1 1 3 1.0

HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................

Thymus + + + + + + + + + + 10Atrophy 1 1 1.0

INTEGUMENTARY SYSTEMNONE

MUSCULOSKELETAL SYSTEMNONE

NERVOUS SYSTEMNONE

RESPIRATORY SYSTEM.........................................................................................................................................................................................................

Lung + + + + + + + + + + 10Inflammation 1 1 2 1.0

TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008

Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56

Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04

Species/Strain: RATS/SD Lab: BAT

DAY ON TEST0216

0216

0216

0216

0216

0216

0216

0216

0216

0216

.................................................................................................................................................................

SPRAGUE-DAWLEY RATSFEMALE

ANIMAL ID100 UG/KG

00361

00362

00363

00364

00365

00376

00377

00378

00379

00380 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 12

Page 13: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … fileSpecies/Strain: RATS/SD Lab: BAT DAY ON TEST 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1

Alveolar Epithelium, Infiltration Cellular,Histiocyte 1 1 1.0

SPECIAL SENSES SYSTEMNONE

URINARY SYSTEMNONE

TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008

Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56

Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04

Species/Strain: RATS/SD Lab: BAT

DAY ON TEST0216

0216

0216

0216

0216

0216

0216

0216

0216

0216

.................................................................................................................................................................

SPRAGUE-DAWLEY RATSFEMALE

ANIMAL ID100 UG/KG

00361

00362

00363

00364

00365

00376

00377

00378

00379

00380 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 13

Page 14: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … fileSpecies/Strain: RATS/SD Lab: BAT DAY ON TEST 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1

ALIMENTARY SYSTEM.........................................................................................................................................................................................................

Liver + + + + + + + + + + 10Clear Cell Focus X X 2Inflammation 1 1 1 2 1 1 1 1 1 1 10 1.1Hepatocyte, Hypertrophy 1 1 1 3 1.0

.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + 10.........................................................................................................................................................................................................

Stomach, Glandular + 1Hyperplasia 2 1 2.0

CARDIOVASCULAR SYSTEMNONE

ENDOCRINE SYSTEM.........................................................................................................................................................................................................

Adrenal Cortex + + + + + + + + + + 10Hypertrophy 1 1 2 3 1.3

.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + 10.........................................................................................................................................................................................................

Thyroid Gland + + + + + + + + + + 10

GENERAL BODY SYSTEM

TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008

Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56

Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04

Species/Strain: RATS/SD Lab: BAT

DAY ON TEST0216

0216

0216

0216

0216

0216

0216

0216

0216

0216

.................................................................................................................................................................

SPRAGUE-DAWLEY RATSFEMALE

ANIMAL ID220 UG/KG

00401

00402

00403

00404

00405

00426

00427

00428

00429

00430 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 14

Page 15: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … fileSpecies/Strain: RATS/SD Lab: BAT DAY ON TEST 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1

NONE

GENITAL SYSTEM.........................................................................................................................................................................................................

Uterus + + + + + + + + + + 10Dilatation 3 1 3.0Inflammation, Suppurative 1 1 1.0Metaplasia, Squamous 1 1 1.0Endometrium, Hyperplasia, Cystic 1 1 1.0

HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................

Thymus + + + + + + + + + + 10Atrophy 1 2 1 3 1.3

INTEGUMENTARY SYSTEMNONE

MUSCULOSKELETAL SYSTEMNONE

NERVOUS SYSTEMNONE

TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008

Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56

Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04

Species/Strain: RATS/SD Lab: BAT

DAY ON TEST0216

0216

0216

0216

0216

0216

0216

0216

0216

0216

.................................................................................................................................................................

SPRAGUE-DAWLEY RATSFEMALE

ANIMAL ID220 UG/KG

00401

00402

00403

00404

00405

00426

00427

00428

00429

00430 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 15

Page 16: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … fileSpecies/Strain: RATS/SD Lab: BAT DAY ON TEST 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1

RESPIRATORY SYSTEM.........................................................................................................................................................................................................

Lung + + + + + + + + + + 10

SPECIAL SENSES SYSTEMNONE

URINARY SYSTEMNONE

TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008

Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56

Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04

Species/Strain: RATS/SD Lab: BAT

DAY ON TEST0216

0216

0216

0216

0216

0216

0216

0216

0216

0216

.................................................................................................................................................................

SPRAGUE-DAWLEY RATSFEMALE

ANIMAL ID220 UG/KG

00401

00402

00403

00404

00405

00426

00427

00428

00429

00430 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 16

Page 17: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … fileSpecies/Strain: RATS/SD Lab: BAT DAY ON TEST 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1

ALIMENTARY SYSTEM.........................................................................................................................................................................................................

Liver + + + + + + + + + + 10Clear Cell Focus X 1Clear Cell Focus, Multiple X 1Inflammation 1 1 1 1 1 1 1 1 1 9 1.0Mixed Cell Focus X 1Pigmentation 1 1 1.0Hepatocyte, Hypertrophy 1 2 1 1 1 1 1 1 8 1.1

.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + 10

CARDIOVASCULAR SYSTEMNONE

ENDOCRINE SYSTEM.........................................................................................................................................................................................................

Adrenal Cortex + + + + + + + + + + 10.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + 10.........................................................................................................................................................................................................

Pituitary Gland + 1Pars Distalis, Cyst 3 1 3.0

.........................................................................................................................................................................................................

Thyroid Gland + + + + + + + + + + 10C-cell, Hyperplasia 3 1 3.0

TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008

Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56

Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04

Species/Strain: RATS/SD Lab: BAT

DAY ON TEST0216

0216

0216

0216

0216

0216

0216

0216

0216

0216

.................................................................................................................................................................

SPRAGUE-DAWLEY RATSFEMALE

ANIMAL ID460 UG/KG

00546

00547

00548

00549

00550

00571

00572

00573

00574

00575 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 17

Page 18: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … fileSpecies/Strain: RATS/SD Lab: BAT DAY ON TEST 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1

GENERAL BODY SYSTEMNONE

GENITAL SYSTEM.........................................................................................................................................................................................................

Uterus + + + + + + + + + + 10Dilatation 3 4 2 3.5Inflammation, Suppurative 1 2 2 1.5Metaplasia, Squamous 1 1 2 1.0

HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................

Thymus + + + + + + + + + + 10Atrophy 1 1 2 1.0

INTEGUMENTARY SYSTEMNONE

MUSCULOSKELETAL SYSTEMNONE

NERVOUS SYSTEMNONE

TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008

Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56

Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04

Species/Strain: RATS/SD Lab: BAT

DAY ON TEST0216

0216

0216

0216

0216

0216

0216

0216

0216

0216

.................................................................................................................................................................

SPRAGUE-DAWLEY RATSFEMALE

ANIMAL ID460 UG/KG

00546

00547

00548

00549

00550

00571

00572

00573

00574

00575 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 18

Page 19: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … fileSpecies/Strain: RATS/SD Lab: BAT DAY ON TEST 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1

RESPIRATORY SYSTEM.........................................................................................................................................................................................................

Lung + + + + + + + + + + 10Inflammation 1 1 2 1.0

SPECIAL SENSES SYSTEMNONE

URINARY SYSTEMNONE

TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008

Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56

Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04

Species/Strain: RATS/SD Lab: BAT

DAY ON TEST0216

0216

0216

0216

0216

0216

0216

0216

0216

0216

.................................................................................................................................................................

SPRAGUE-DAWLEY RATSFEMALE

ANIMAL ID460 UG/KG

00546

00547

00548

00549

00550

00571

00572

00573

00574

00575 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 19

Page 20: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … fileSpecies/Strain: RATS/SD Lab: BAT DAY ON TEST 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1

ALIMENTARY SYSTEM.........................................................................................................................................................................................................

Liver + + + + + + + + + + 10Clear Cell Focus X X X 3Hematopoietic Cell Proliferation 1 1 1.0Inflammation 2 3 1 2 1 1 1 1 2 1 10 1.5Mixed Cell Focus X 1Necrosis 1 1 1.0Pigmentation 1 1 1 1 1 1 6 1.0Hepatocyte, Hypertrophy 1 2 1 1 2 1 1 2 2 1 10 1.4Oval Cell, Hyperplasia 1 1 1.0

.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + 10Inflammation, Chronic Active 2 1 2.0

CARDIOVASCULAR SYSTEMNONE

ENDOCRINE SYSTEM.........................................................................................................................................................................................................

Adrenal Cortex + + + + + + + + + + 10Degeneration, Cystic 2 1 2.0Hypertrophy 1 2 2 3 1.7

.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + 10.........................................................................................................................................................................................................

TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008

Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56

Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04

Species/Strain: RATS/SD Lab: BAT

DAY ON TEST0216

0216

0216

0216

0216

0216

0216

0216

0216

0216

.................................................................................................................................................................

SPRAGUE-DAWLEY RATSFEMALE

ANIMAL ID1000 UG/KG

00621

00622

00623

00624

00625

00631

00632

00633

00634

00635 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 20

Page 21: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … fileSpecies/Strain: RATS/SD Lab: BAT DAY ON TEST 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1

Thyroid Gland + + + + + + + + + + 10C-cell, Hyperplasia 1 1 1.0Follicular Cell, Hypertrophy 2 2 2 2.0

GENERAL BODY SYSTEMNONE

GENITAL SYSTEM.........................................................................................................................................................................................................

Uterus + + + + + + + + + + 10Dilatation 2 3 3 3 2.7Inflammation, Suppurative 1 1 1.0Metaplasia, Squamous 1 1 1 1 4 1.0

HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................

Thymus + + + + + + + + + + 10Atrophy 1 1 1.0

INTEGUMENTARY SYSTEMNONE

MUSCULOSKELETAL SYSTEMNONE

TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008

Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56

Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04

Species/Strain: RATS/SD Lab: BAT

DAY ON TEST0216

0216

0216

0216

0216

0216

0216

0216

0216

0216

.................................................................................................................................................................

SPRAGUE-DAWLEY RATSFEMALE

ANIMAL ID1000 UG/KG

00621

00622

00623

00624

00625

00631

00632

00633

00634

00635 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 21

Page 22: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … fileSpecies/Strain: RATS/SD Lab: BAT DAY ON TEST 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1

NERVOUS SYSTEMNONE

RESPIRATORY SYSTEM.........................................................................................................................................................................................................

Lung + + + + + + + + + + 10Alveolar Epithelium, Hyperplasia 1 1 1.0Alveolus, Infiltration Cellular, Histiocyte 1 1 1.0

SPECIAL SENSES SYSTEMNONE

URINARY SYSTEMNONE

TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008

Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56

Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04

Species/Strain: RATS/SD Lab: BAT

DAY ON TEST0216

0216

0216

0216

0216

0216

0216

0216

0216

0216

.................................................................................................................................................................

SPRAGUE-DAWLEY RATSFEMALE

ANIMAL ID1000 UG/KG

00621

00622

00623

00624

00625

00631

00632

00633

00634

00635 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 22

Page 23: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … fileSpecies/Strain: RATS/SD Lab: BAT DAY ON TEST 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1

ALIMENTARY SYSTEM.........................................................................................................................................................................................................

Liver + + + + + + + + + + 10Cholangiofibrosis 2 1 2.0Fatty Change, Diffuse 3 3 3 3 2 3 3 2 3 3 10 2.8Inflammation 2 2 3 2 2 2 2 2 2 2 10 2.1Mixed Cell Focus X 1Pigmentation 1 1 2 2 2 2 2 1 1 2 10 1.6Toxic Hepatopathy 1 1 1 1 1 1 1 1 1 1 10 1.0Bile Duct, Hyperplasia 1 1 2 1.0Hepatocyte, Hypertrophy 3 3 3 3 3 3 3 3 3 3 10 3.0Hepatocyte, Multinucleated 1 1 1 1 1 1 2 1 1 1 10 1.1Oval Cell, Hyperplasia 1 1 1 1 1 2 1 1 1 9 1.1

.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + 10Acinus, Atrophy, Focal 1 1 1.0Acinus, Vacuolization Cytoplasmic 2 1 1 1 1 1 6 1.2

.........................................................................................................................................................................................................

Stomach, Forestomach + + + + + + + + + + 10Edema 1 1 1.0Inflammation 1 2 2 1.5

.........................................................................................................................................................................................................

Stomach, Glandular + + + + + + + + + + 10

CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................

Blood Vessel + 1

TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008

Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56

Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04

Species/Strain: RATS/SD Lab: BAT

DAY ON TEST0216

0216

0216

0216

0216

0216

0216

0216

0216

0216

.................................................................................................................................................................

SPRAGUE-DAWLEY RATSFEMALE

ANIMAL ID4600 UG/KG

00736

00737

00738

00739

00740

00761

00762

00763

00764

00765 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 23

Page 24: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … fileSpecies/Strain: RATS/SD Lab: BAT DAY ON TEST 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1

ENDOCRINE SYSTEM.........................................................................................................................................................................................................

Adrenal Cortex + + + + + + + + + + 10Atrophy 2 1 2.0Degeneration, Cystic 1 1 1.0Hypertrophy 2 1 2 1.5

.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + 10.........................................................................................................................................................................................................

Pituitary Gland + + + + + + + + + + 10.........................................................................................................................................................................................................

Thyroid Gland + + + + + + + + + + 10Follicular Cell, Hypertrophy 3 1 2 2 1 1 3 1 8 1.8

GENERAL BODY SYSTEMNONE

GENITAL SYSTEM.........................................................................................................................................................................................................

Ovary + + + + + + + + + + 10.........................................................................................................................................................................................................

Uterus + + + + + + + + + + 10Dilatation 4 1 4.0

.........................................................................................................................................................................................................

TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008

Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56

Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04

Species/Strain: RATS/SD Lab: BAT

DAY ON TEST0216

0216

0216

0216

0216

0216

0216

0216

0216

0216

.................................................................................................................................................................

SPRAGUE-DAWLEY RATSFEMALE

ANIMAL ID4600 UG/KG

00736

00737

00738

00739

00740

00761

00762

00763

00764

00765 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 24

Page 25: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … fileSpecies/Strain: RATS/SD Lab: BAT DAY ON TEST 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1

Vagina + + + + + + + + + + 10

HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................

Spleen + + + + + + + + + + 10Pigmentation 1 1 1 1 1 2 2 1 1 1 10 1.2

.........................................................................................................................................................................................................

Thymus + + + + + + + + + + 10Atrophy 2 2 2 2.0

INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................

Mammary Gland + + + + + + + + + + 10

MUSCULOSKELETAL SYSTEMNONE

NERVOUS SYSTEMNONE

RESPIRATORY SYSTEM.........................................................................................................................................................................................................

Lung + + + + + + + + + + 10Hemorrhage 1 1 2 1.0Alveolus, Infiltration Cellular, Histiocyte 1 1 1 3 1.0

TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008

Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56

Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04

Species/Strain: RATS/SD Lab: BAT

DAY ON TEST0216

0216

0216

0216

0216

0216

0216

0216

0216

0216

.................................................................................................................................................................

SPRAGUE-DAWLEY RATSFEMALE

ANIMAL ID4600 UG/KG

00736

00737

00738

00739

00740

00761

00762

00763

00764

00765 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 25

Page 26: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … fileSpecies/Strain: RATS/SD Lab: BAT DAY ON TEST 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1 6 0 2 1

SPECIAL SENSES SYSTEMNONE

URINARY SYSTEMNONE

*** END OF REPORT ***

TDMS No. 20304 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/24/2008

Test Type: CHRONIC TEF evaluation (PCB 118) Time Report Requested: 13:39:56

Route: GAVAGE CAS Number: 31508-00-6 First Dose M/F: NA / 03/26/04

Species/Strain: RATS/SD Lab: BAT

DAY ON TEST0216

0216

0216

0216

0216

0216

0216

0216

0216

0216

.................................................................................................................................................................

SPRAGUE-DAWLEY RATSFEMALE

ANIMAL ID4600 UG/KG

00736

00737

00738

00739

00740

00761

00762

00763

00764

00765 * TOTALS

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

Page 26


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2013년 0월 0일...은 행 Analyst 최정욱, CFA 02-3771-3643 6 하나금융 0 0 0 0 0 0 0 6 8 0 2 2 4 6 8 0 2 2 4 6 (원) 하나금융지주 수정TP 날짜 투자의견 목표주가

2013년 0월 0일...은 행 Analyst 최정욱, CFA 02-3771-3643 6 하나금융 0 0 0 0 0 0 0 6 8 0 2 2 4 6 8 0 2 2 4 6 (원) 하나금융지주 수정TP 날짜 투자의견 목표주가

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arXiv:1909.10618v2 [cs.LG] 30 Dec 2019 · AntMaze AntPush AntBlock AntBlockMaze 0:0 0:2 0:4 0:6 0:8 1:0 0:0 0:2 0:4 0:6 0:8 0:0 0:2 0:4 0:6 0:8 1:0 0:0 0:2 0:4 0:6 0:8 1:0 HIRO HIRO

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