OutlineLearning Objectives Analyze the cell cycle and its relationship to cancerEvaluate the role of life style and risk factors that might contribute to cancer Scientific ReasoningEvaluate popular literature as it relates to Formative AssessmentsThink Pair Share Activities/Clickers to identify cellular changes in cancer cells

Summative AssessmentEvaluate a claim on the ability of ellagic acid in raspberries to prevent cancer

Figure 5.12 Biology: Science for Life 2/e ©2007 Pearson Prentice Hall, Inc.

G1

G2

M

S

Cell cycle

G1 checkpointG2 checkpoint

Metaphase checkpoint

• Are all the chromosomesattached to microtubules?

• Are sufficient nutrientsavailable?

• Is the cell large enough?

• Are growth factors present?

• Is cell division necessary?

• Is the cell largeenough?

• Was DNAreplicated correctly?

Tumor suppressors- stopGrowth factors- go

Cell Cycle Control and Mutation - Many Mutations Are Required for Cancer to Develop

Progression from benign tumor to cancer requires many mutations. Immortalization Loss of contact inhibition Angiogenesis Loss of anchorage dependence

Where is the Tumor?

AC

B

D

Is the Normal Colon on the Right or the Left?

BA

Think Pair Share

• What do these pictures have in common?

Think Pair Share

• What is different between these two panels?

What specific areas of the cell cycle appear to be affected?

Class Data1. Does Family History play a pivotal role in the

development of cancer? Explain2. What were the top three cancers? In your

opinion why were these cancers the most popular?

3. What was the most common possible risk factor?4. Cancer is often described as the disease of the

aged. This statement may be inconsistent with your class data. What explanation can you offer in support of this statement?