Orthopaedics and Trauma Queensland

A N N U A L R E P O R T 2 0 0 8

› AO BRisBANE sPiNE

REfERENcE cENTRE

› MEdicAL ENgiNEERiNg

› NORThsidE sPiNE

REsEARch gROUP

› ORThOPAEdic

REsEARch gROUP

› PAEdiATRic sPiNE

REsEARch gROUP

› REgENERATivE

MEdiciNE gROUP

› TRAUMA REsEARch gROUP

HeadingContents

inTrOducTiOn inside front

direcTOr’s message inside front

research and highlighTs › research Overview 1 › selected Project highlights 1

research FaciliTies › institute of health and Biomedical

innovation (ihBi) 4 › Faculty of Built environment and

engineering 4 › medical engineering research

Facility (merF) 4

highlighTs OF The Year 5

naTiOnal cOmPeTiTive granTs 7

OTher granTs 8

PuBlicaTiOns › Book chapters 10 › Journal articles 10 › guest editors 11 › international conference

Presentations 12 › australian/new Zealand

conference Presentations 12 › guest Presentations 14

sTaFF 15

adJuncT PrOFessOrial sTaFF 17

higher degree research sTudenTs › new students 18 › continuing students 18 › completions 19 › Overseas visiting students 19

awards, PriZes and cOmmuniTY service 20

acknOwledgemenTs inside back

fOR fURThER iNfORMATiON PhOne +61 7 3138 6000 Fax +61 7 3138 6030 email orthotraumaqld@qut.edu.auwww.ihbi.qut.edu.au/research/medical_device.jsp

iNTROdUcTiON

Orthopaedics and Trauma Queensland is an internationally recognised research group that

is developing into an international leader in research and education. it provides a stimulus

for research, education and clinical application within the international orthopaedic and

trauma communities.

Orthopaedics and Trauma Queensland develops and promotes the innovative use of

engineering and technology, in collaboration with surgeons, to provide new techniques,

materials, procedures and medical devices. its integration with clinical practice and strong links

with hospitals ensure that the research will be translated into practical outcomes for patients.

The group undertakes clinical practice in orthopaedics and trauma and applies core

engineering, modelling and clinical skills to challenges in medicine. The research is built on

a strong foundation of knowledge in biomedical engineering and incorporates expertise in

cell biology, mathematical modelling, human anatomy and physiology and clinical medicine

in orthopaedics and trauma. new knowledge is being developed and applied to the full

range of orthopaedic diseases and injuries, such as knee and hip replacements, fractures

and spinal deformities.

diREcTOR’s MEssAgE

welcome to the third Orthopaedics and Trauma Queensland

(O&TQ) annual report.

2008 was an exciting year with staff moving into the medical

engineering research Facility (merF) on the site of The Prince

charles hospital and the official opening on 16th september. merF

is already very busy running surgical skills workshops and the extra

research facilities are providing an impetus for accelerating research

activity in the group.

The research output of O&TQ continues to impress. in 2009 we are looking to develop our

international linkages and to investigate further funding avenues. in the first half of 2009

the group has continued to grow in numbers and research activity. Full details of these

activities will be provided in the 2009 annual report.

at the end of 2008 Professor dietmar w hutmacher took over as the medical device

domain leader in the institute of health and Biomedical innovation (ihBi), and associate

Professor clayton adam took over as the medical engineering Theme leader in the

Faculty of Built environment and engineering. These changes will provide us with a fresh

impetus to develop O&TQ into the future.

in addition, we have restructured O&TQ and i have pleasure in announcing that dr Peter

Boys, from the Queensland Orthopaedic research Trust has accepted the position of

chair of O&TQ. he will be leading our initiatives to position O&TQ both nationally and

internationally over the following year.

whilst i am standing down from some leadership positions i will still be intimately involved

in the activities of O&TQ. next year’s report will be led by Peter, clayton and dietmar and

i’m looking forward to the exciting prospects for the next few years.

Mark Pearcy Bsc, Phd, fiEAust, cPEng (Biomed)Professor of Biomedical engineering director, medical engineering research Facility

R e s e a R C H a n d H i g H l i g H t s [ 1 ]

Research and highlights

REsEARch OvERviEw

The research of Orthopaedics and Trauma

Queensland seeks to solve problems in a

broad range of areas, including:

sELEcTEd PROjEcT highLighTs

1. AO Brisbane spine Reference centre – Reducing secondary degeneration after spinal cord injury

The neurological damage from a spinal

cord injury is believed to be localised,

however it initiates a cascade of secondary

events which usually leads to extensive

and permanent paralysis. This secondary

damage begins with the disruption

of the blood – spinal cord barrier and

unleashes the body’s normal response

to tissue damage, inflammation. unlike

successful wound healing in other

tissues, inflammation in the spinal cord is

ongoing and can be observed for weeks

and months afterwards. This prolonged

inflammatory response is the catalyst for

secondary neurodegeneration and a major

reason for the limited repair response that

occurs naturally. in this ongoing work we

proposed that by early amplification of the

population and activation of inflammatory

cells, the inflammation would reach a

self limiting threshold and secondary

degeneration would not occur. we have now

shown that this is the case and Figure 1

below shows the difference between a

spinal cord where the inflammation has

been amplified (bottom) and one where it

has not (top). This work was recognised

by the spine society of australia research

award for 2008, and dr Ben goss was also

named runner up in the 2008 australian

society for medical research, Queensland

Premier’s award for senior Post-doctoral

medical researchers.

Figure 1. Images of two damaged spinal cords where the inflammation has been amplified (bottom) and one where it has not (top).

2. Medical Engineering – Probing the condition of cartilage during arthroscopy

a new quantitative arthroscopy system is

being developed to address the issues of

early stage detection of the causes of joint

degeneration and osteoarthritis in particular.

This device being developed by Professor

kunle Oloyede and Professor ross

crawford will be able to identify and

quantify the level of degradation of the

major components of articular cartilage.

The consequence of this capability will

be the elimination of subjectivity in the

visual assessment process which currently

limits the direct application of arthroscopic

evaluation to treatment.

The device will extend current grading

systems of the osteoarthritic condition to aid

treatment decisions, enabling the matching

of symptoms to surgical operations.

Furthermore, post-operative evaluation of

the healing process will be possible, leading

to the assessment of the effectiveness of

particular treatment methods.

Of significance is the inherent capacity of

this new device, the smarthroscope, to

categorise and quantify joint degeneration

in younger members of the population, so

that early intervention could be carried out.

The project will lead to potential reductions

in the need for extensive surgical

experience before effective diagnosis

and treatment decisions can be made.

Therefore the outcome will be beneficial to

regions of the world with limited surgical

expertise and facilities, such as developing

countries. more clinicians will be able

to participate in the treatment process

through quantitative diagnosis.

3. Northside spine Research group – Databases for clinical review of spine surgery procedures

The northside spine research group

is currently focused on developing

comprehensive clinical databases for a

range of spine surgery procedures to assess

the clinical efficacy of surgical treatments

for lumbar spinal disorders. Procedures

being assessed include: anterior lumbar

interbody fusion (aliF), transforaminal

lumbar interbody fusion (TliF), discectomy

(intervertebral disc removal), and

laminotomy/laminectomy procedures.

while the database development is

at an early stage, the potential for

improvement in clinical outcomes is

demonstrated in a current study of 78

patients undergoing spine fusion (TliF)

with a polyethylethylketone (Peek)

implant and bone morphogenetic protein

(BmP) to promote bony fusion. regular

post-operative assessment found early

complications in eight patients, two of

which were not linked with BmP. Fluid cyst

formation in the spinal canal in the region

of the posterior cage and the adjacent

› Biomaterials and bone substitutes

› cartilage biomechanics

› cell biomechanics › cell biology › clinical research › epidemiology › Fracture healing › Joint lubrication › mathematical

modelling › mechanical

testing

› Osteoarthritis › regenerative

medicine › spinal deformity › spinal disease › surgical

complications › surgical implants › Tissue

engineering › Tissue

mechanics › wound healing › Osteoporosis

[ 2 ] R e s e a R C H a n d H i g H l i g H t s

epidural space were seen on post-operative

magnetic resonance imaging (mri) in four

patients. no such complications were seen

in 33 patients who previously underwent

TliF using a similar technique but where

bone graft rather than BmP was used.

Preliminary results indicate that, after a

change of BmP dose, fusion rates and

outcomes in these patients were improved.

The change in BmP dose and its effect on

bony union is being investigated over the

longer term by reviewing fusion rates pre

and post procedural change.

4. Orthopaedic Research group – Femoral nails for the developing world

whilst intramedullary nailing is a commonly

accepted technique for lower limb fracture

fixation, the cost of nails can be prohibitive

in hospitals in developing nations. in these

institutions bone cement has found many

‘off label’ applications, that whilst effective

do not meet manufacturer’s guidelines.

The aim of this study was to examine the

biomechanics of one such application,

fracture fixation using a bone cement

intramedullary nail.

The experiment involved creating a broken

femur then fixing the fracture using a nail

made from antibiotic simplex bone cement.

intramedullary nails made from bone cement

were able to provide sufficient promise in

this situation to warrant further investigation

for their applicability as a low cost alternative

for use in developing countries (Figure 2).

Figure 2. Example of fracture fixation using bone cement

5. Paediatric spine Research group – Patient specific computer modelling of spinal deformity surgery

researchers in the Paediatric spine

research group are using computer

modelling techniques to assist surgeons

in better predicting surgical outcomes for

scoliosis patients. The computer models

are developed using a patient’s computed

tomography (cT) scans and include

representations for the bone geometry and

spinal soft tissues as well as the devices

implanted by the surgeon. These devices

include metal rods which are attached

to the patient’s spine with screws and

tightened to correct the spinal deformity.

By simulating the forces applied to the

patient’s spine both during and after

surgery, it is possible to predict stresses

and strains in the implant and spinal tissue.

using this information, possible overload

of the spine and implant materials can

be predicted and thus, post-operative

complications (such as screw loosening

or tissue damage) can be avoided. By

predicting the outcomes of surgical

procedures in individual patients before

they are carried out, this will provide

surgeons with a pre-operative planning

tool to reduce surgical complications

and improve patient outcomes following

scoliosis surgery (Figure 3).

Figure 3. Full spine computer model of a scoliosis patient with surgical implant attached. Screws (green) are embedded in the spinal bones, called vertebrae (purple) and when attached to a rod (green), they reduce the curved deformity.

6. Regenerative Medicine group – Establishment of large preclinical animal models for critical sized bone defect healing

in collaboration with the Orthopaedic and

Trauma research groups, Professor dietmar

hutmacher’s regenerative medicine group

is combining basic science with advanced

surgical techniques, to develop innovative

and translational (from bench to bedside)

bone tissue engineering technologies for

treating segmental bone defects.

The reconstruction of large bone segments

(Figure 4) remains a significant clinical

problem. large bone defects occur

mainly as a result of extensive bone

loss due to pathological events such

as trauma, inflammation, and surgical

treatment of tumours. Present therapeutic

approaches include the application of

bone graft transplants (autograft, allograft,

xenograft), as well as implants made of

different synthetic and natural biomaterials.

however, no existing therapy has been

proven to be fully satisfactory.

R e s e a R C H a n d H i g H l i g H t s [ 3 ]

The area of bone tissue engineering (which

has its main focus on the development

of bioactive materials) offers significant

potential for bone defect reconstruction.

To tackle major bone tissue engineering

problems however, it is essential that

animal models, fixation devices, surgical

procedures and measurement methods

are standardized to allow the accumulation

of a reliable data pool as a base for further

research directions.

in order to study a tissue engineered

construct it is necessary to develop an

animal model which represents the clinical

situation as closely as possible. Based on a

recent review by the regenerative medicine

group (reichert Jc et al, 2009 Biomaterials

30:2149–2163), 7–9 year old sheep

are considered to be the most suitable

animals for use in an experimental model

of bone defect healing. in mature sheep,

bone consists principally of primary bone

structure in comparison with the largely

secondary, haversian bone composition of

humans. secondary osteonal remodelling

in sheep only takes place at an average

age of 7–9 years. Therefore, only older

sheep have a bone biology that is similar to

that in humans.

multidisciplinary approaches are essential

to realise the vision of treating large

segmental tibia defects by using novel

scaffolds in combination with either cells

or growth factors, and the regenerative

medicine group has assembled a team of

engineers, basic scientists and surgeons,

with the aim of allowing australia to

become a leading player in this exciting

and competitive field.

Figure 4: Implantation of a medical grade PCL-TCP scaffold loaded with 3 mg of BMP-7 into a critical sized bone defect of a sheep tibia

7. Trauma Research group – The influence of surgical approach on fracture healing outcomes

The Trauma research group has recently

completed an animal study in sheep to

determine whether the surgical approach

– the way in which a fixation implant is

applied to the fractured bone – has any

influence on the healing outcome of bone

fractures (Figure 5). minimally invasive

(so-called ‘keyhole’) surgery has become

a popular method to apply fracture fixation

plates, with fewer fractures treated by a

traditional open reduction internal fixation,

where the fracture site is exposed along

the entire length of the implanted fracture

fixation plate. however, while the newer

method offers obvious cosmetic (smaller

scars) and other potential advantages

(e.g. reduced infection risk), it comes at

the cost of increased exposure to x-ray

radiation and is generally more demanding

for the surgeon.

while the complete evaluation of the

experiments is still ongoing, initial results

indicate advantages for fractures treated in

a minimally invasive fashion. The minimally

invasive surgical approach resulted in less

damage to the soft tissues surrounding

the fracture. This was demonstrated by

analysis of clinical markers for muscle

injuries in the circulating blood. mechanical

testing of the healing bone, which is a

measure of healing outcome, showed an

earlier recovery of strength and stiffness

for the fractures treated with the minimally

invasive approach.

These first results demonstrate that

minimally invasive surgery for the internal

fixation of bone fractures, despite being

more demanding for the surgeon, leads

to outcomes that are comparable, if

not better, than those achieved using

traditional surgical methods. These results

have direct clinical implications and will

further aid the development of improved

surgical methods for the application of

fracture fixation implants.

Figure 5. Dr Martin Wullschleger (right) and Dr Sadahiro Sugiyama (left) operating during the sheep study to compare minimally invasive and open approaches for fracture fixation.

[ 4 ] R e s e a R C H f a C i l i t i e s

Research facilities

iNsTiTUTE Of hEALTh ANd BiOMEdicAL iNNOvATiON (ihBi)

QUT Kelvin grove campus › laboratories for cell culture, mechanical and materials Testing, Polymer chemistry, Tissue

mechanics, Bone and cartilage instrumentation, histology and micro-computed Tomography › mechanical and electronics workshop › seminar room

fAcULTy Of BUiLT ENviRONMENT ANd ENgiNEERiNg

QUT gardens Point campus › cell culture and mechanical Testing laboratories › rapid Prototyping Facility › six axis spine testing robot › nanoindentation (umis 2000) › seminar room

MEdicAL ENgiNEERiNg REsEARch fAciLiTy (MERf)

The Prince charles hospital › Operating Theatre › anatomical skills laboratory › materials Testing, cell culture, histology, Physiology and general project laboratories › seminar room

Computer simulations are used to quantify and optimise the anatomical fit of fracture fixation implants, in this case an intramedullary nail for tibia fractures.

H i g H l i g H t s o f t H e y e a R [ 5 ]

Highlights of the year

fAcTs ANd figUREs

86 staff

40 postgraduate students, including ten new postgraduate students and six postgraduate completions

$3 million research income

2 book chapters, 42 journal papers, 17 international conference presentations, 29 australian/new Zealand conference presentations

significant international links continued

MEdicAL ENgiNEERiNg REsEARch fAciLiTy BEgiNs OPERATiON › eight Queensland university of

Technology (QuT) staff › Four Queensland health (Qh) staff based

at the facility › Occupancy from February 2008 › Official Opening on 16 september 2008

Official Opening of MERfOn 16 september 2008 the medical

engineering research Facility (merF)

was officially opened by the state health

minister, the hon stephen robertson.

(Figures 6 and 7).

Figure 6. MERF at sunset

merF is a $10.7 million research and

training facility located in the grounds of

The Prince charles hospital in chermside,

Brisbane. it aims to lead australia in

orthopaedic, critical care and artificial

organ research. The medical engineering

research Facility has been funded by a

Queensland government smart state

Facilities grant of $5 million in addition to

$4.15 million from QuT.

The Prince charles hospital provided

the land as well as equipment and staff

support. Funding and equipment was also

provided by industry partners, medtronic

sofamor danek and stryker, each of whom

contributed significant cash and in-kind

support in the form of equipment.

The state-of-the-art facility offers operating

theatres, cell culture laboratories, materials

testing laboratories, mechanical and

electrical workshops and teleconferencing

technology which can link the centre to

the world.

Figure 7: QUT Vice Chancellor, Prof Peter Coaldrake (left) with Prof Ross Crawford (centre) and Prof Mark Pearcy (right) at the MERF opening.

visiT TO ihBi By ThE swiss AMBAssAdOR – dR dANiEL wOKER

The swiss ambassador to australia, dr daniel woker, visited ihBi on 21 October 2008

(Figure 8). dr woker was presented with an overview of the research activities of O&TQ, whose

members already have significant links to swiss research institutions, universities and industry.

dr woker will use his impressions to raise awareness of the strong research programs in

Queensland and australia at swiss universities and in industry, and will explore ways to foster

the development of further collaborative links between the two countries.

Figure 8. Swiss ambassador to Australia, Dr Daniel Woker (4th from right) with QUT research staff.

[ 6 ] H i g H l i g H t s o f t H e y e a R

OPTOTRAK MOTiON TRAcKiNg sysTEM

Thanks to the generous support of the

Queensland Orthopaedic research Trust,

together with funds from Queensland

university of Technology, O&TQ

researchers have been able to purchase an

Optotrak which incorporates specialised

sensor technology and sophisticated

optics to measure and track 3d motion

and position with high resolution. Figure

9 shows the Optotrak being used to

measure vertebral motions of a calf spine

and ribcage during biomechanical testing

of scoliosis correction implants in QuT’s

six-axis testing robot.

Figure 9. Biomechanical testing of a spine with Optotrak markers attached to the spinous processes to measure motion during the test.

QUT sMART TRAiN

The QuT smart Train set off from ipswich

in may 2008, to travel throughout the

state of Queensland for six weeks, with its

final week spent in Brisbane. all faculties

at QuT joined forces to create another

exciting and worthwhile experience for the

rural and regional communities around

Queensland. it is one of the state’s largest

community outreach programs, having

hosted over 90 000 visitors to date. One of

the four carriages featured O&TQ research

activities and games including ‘Professor

crawford’s bone quiz’, and an interactive

‘spine surgery game’ which both proved to

be extremely popular.

a smart Train event on the Toowoomba

platform was combined with the launch

of the mater children’s hospital annual

fundraiser, ‘5 k’s for kids’. The Paediatric

spine research group were featured on

the Toowoomba platform representing

the successful collaborative partnership

between mater clinicians and QuT

researchers (Figure 10).

Figure 10. Assoc Prof Clayton Adam at the 2008 QUT Smart Train and Mater Foundation Toowoomba platform event.

Top right: Research Assistant Maree Izatt with scoliosis patient Shuang Hu.

Centre right: QUT IHBI Fundraising Manager Anna Herbert with Qld Rail representative.

Bottom right: Mater Foundation Director Nigel Harris with Qld School Children.

n a t i o n a l C o m p e t i t i v e g R a n t s [ 7 ]

national competitive grants

gRANT arc discovery grant

TiTLE Patient-specific biomedical modelling for improved treatment of spinal deformity

chiEf iNvEsTigATORs m Pearcy, c adam, J evans, g askin

fUNdiNg 2006–2008, $342 680

gRANT arc discovery grant

TiTLE engineering articular cartilage with zonal structure and function

chiEf iNvEsTigATORs d hutmacher, T klein, J malda, r sah

fUNdiNg 2007–2011, $523 934aPd Travis klein, $235 944

gRANT arc discovery grant

TiTLE Bilayered and growth factor-loaded composite scaffolds for the guided bi-differentiation of bone marrow mesenchymal stem cells.

chiEf iNvEsTigATORs x miao, Y xiao, r crawford

fUNdiNg 2008–2010, $255 000

gRANT arc linkage grant

TiTLE development of a prothrombogenic bone graft substitute

chiEf iNvEsTigATORs r crawford, m schuetz, a stemberger, B goss, B scott

fUNdiNg 2006–2008, $184 000

gRANT arc linkage grant

TiTLE understanding the biomechanical effects of fixation strategies to improve the technology of fracture management

chiEf iNvEsTigATORs m schuetz, s mishra, g chen, s Perran

fUNdiNg 2007–2010, $280 000

gRANT nhmrc development grant

TiTLE The next generation of Biomaterials; in vivo assessment of lumbar spine fusion biodegradable interbody cages

chiEf iNvEsTigATORs B goss, c lutton

fUNdiNg 2008–2010, $82 500

gRANT nhmrc development grant

TiTLE development of a smart arthroscopy system and prototype probe for joint tissue

chiEf iNvEsTigATORs a Oloyede, r crawford

fUNdiNg 2008–2010, $212 375

gRANT nhmrc australia-china exchange Fellowship

TiTLE development of gene-activated scaffolds as bone bioreactor for bone regeneration and osseointegration

chiEf iNvEsTigATORs Y Zhang, Y xiao

fUNdiNg 2008–2010, $215 000

[ 8 ] o t H e R g R a n t s

other grants

gRANT Queensland department of state development, smart state Fellowship

TiTLE development and characterisation of an osteoinductive polymeric bone graft substitute material for use in orthopaedic surgery

chiEf iNvEsTigATORs B goss

fUNdiNg 2006–2008, $150 000

gRANT wesley research institute

TiTLE Prevention of bacterial bone infections in mice with implant coatings for delivery of antibiotics, demonstrated by in vivo biophonic imaging

chiEf iNvEsTigATORs m schuetz, r steck, d mcmillan, B goss, s sommerville, a stemberger

fUNdiNg 2007–2008, $52 000

gRANT The Princess alexandra hospital Foundation

TiTLE health status and economic outcomes of critically ill trauma patients

chiEf iNvEsTigATORs l aitken, w chaboyer, m schuetz, e kendell, c Joyce

fUNdiNg 2008, $50 000

gRANT synthes

TiTLE morphology database for fracture modelling, implant design & optimisation

chiEf iNvEsTigATORs B schmutz, m schuetz

fUNdiNg 2008, $88 000

gRANT ihBi early career researcher

TiTLE evaluation of an implantation sensor to monitor pressure, oxygen tension and temperature in vivo over extended periods during bone regeneration

chiEf iNvEsTigATORs d epari

fUNdiNg 2008–2009, $9 500

gRANT statewide Trauma clinical network

TiTLE a reference Process model for multi-Trauma Patients

chiEf iNvEsTigATORs s clemens, m rosemann, m schuetz, m sinnott, B lowe

fUNdiNg 2008–2010, $106 000

gRANT statewide Trauma clinical network

TiTLE development of an integrated Trauma management system for head injury

chiEf iNvEsTigATORs g chattopadhyay, s mishra, s rashford, m schuetz, J kemsley, s halder, Y Toft

fUNdiNg 2008–2010, $118 000

gRANT department of education, science and Training international science linkages, australia – china fund for science and Technology co-operation

TiTLE developing tissue engineered product for clinical application using a model of temporomandibular joint disorders

chiEf iNvEsTigATORs Y xiao, r crawford, x miao

fUNdiNg 2008, $45 000

gRANT royal australasian college of surgeons Fellowship 2007–2008

TiTLE Benchmarking trauma care performance in a tertiary hospital in Queensland to european trauma centres: using the european registry as a model

chiEf iNvEsTigATORs m schuetz, l aitken, B Boullion, r lefering, T davey

fUNdiNg 2007–2008, $50 000

o t H e R g R a n t s [ 9 ]

gRANT Prostate cancer Foundation of australia grant

TiTLE application of a human bone engineering platform to an in-vivo prostate cancer model

chiEf iNvEsTigATORs d hutmacher, T klein, J reichert

fUNdiNg 2008, $395 000

gRANT australian Orthopaedic association

TiTLE Tissue engineering as a potential approach for the treatment of osteonecrosis

chiEf iNvEsTigATORs r crawford, x miao, Y xiao

fUNdiNg 2008, $32 261

gRANT aO research Foundation

TiTLE effect of surgical approach on fracture healing

chiEf iNvEsTigATORs m wullschleger, m schuetz, k ito

fUNdiNg 2005–2008, $130 000

gRANT marian and eh Flack Trust

TiTLE improving treatment outcomes for children with scoliosis: practical use of computer modelling

chiEf iNvEsTigATORs c adam

fUNdiNg 2008, $25 000

[ 1 0 ] p u b l i C a t i o n s

BOOK chAPTERs

1. gadomski a, kruszewska n, santamaria-holek k, uher JJ, Pawlak Z, Oloyede a, Pechkova e, nicolini c. can modern statistical mechanics unravel some practical problems encountered in model biomatter aggregations emerging in internal and external-friction conditions? Statistical Mechanics Research. nOva science Publishers, ed. Byung-soo kim, 2008, isBn: 978-1 60456-029-9.

2. miao x, gorring n. Nanoceramics and nanoceramic composites for biomedical applications. in Handbook of Nanoceramics and their based Nanodevices, eds. Tseung-Yuen Tseng and hari singh nalwa, american scientific Publishers, January 2008, isBn: 1-58883-114-0.

jOURNAL ARTicLEs

1. adam cJ, askin gn, Pearcy mJ. gravity-induced torque and intravertebral rotation in idiopathic scoliosis. Spine. 2008; 33:e30-e37.

2. Beldiman m, xiao Y, crawford r, Oloyede a. cell response in mixtures of surfactant-culture medium – towards a systemic approach to cell-based treatments for focal osteoarthritis. Biosystems. 2008; 94:209–14.

3. Beldiman m, xiao Y, crawford rw, Oloyede a. cell response in mixtures of surfactant-culture medium – towards a systemic approach to cell-based treatments for focal osteoarthritis. Biosystems. 2008; 94:209–214.

4. Berndt c, ganko a, whitehouse sl, crawford rw. heterotopic ossification within an arthroscopic portal after uneventful partial meniscectomy. Knee. 2008; 15:416–18.

5. Blom aw, rogers m, Taylor ah, Pattison g, whitehouse sl, Bannister gc. dislocation following total hip replacement. The Avon experience. Ann R Coll Surg Engl. 2008; 90:658–662.

6. Brown cP, hughes sw, crawford rd, Oloyede a. joint laminate degradation assessed by reflected ultrasound from the cartilage surface and osteochondral junction. Phys Med Biol. 2008; 53:4123–35.

7. Brown cP, crawford rw, Oloyede a. in search of a parameter to distinguish viable from non-viable articular cartilage – indentation and ultrasound studies. Advanced Materials Research. 2008; 32:223–228.

8. chen Y, dong Z, miao x. The effects of yttria-stabilised zirconia on the properties of the fluorine – substituted hydroxyapatite ceramics prepared by pressureless sintering. Journal of Biomimetics, Biomaterials and Tissue Engineering. 2008; 1:57–68.

9. chen Z, ekaputra a, gauthaman k, adaikan P, Yu h, hutmacher d. in vitro and in vivo analysis of co-electrospun scaffolds made of medical grade poly (epsilon-caprolactone) and porcine collagen. J Biomaterials Sci Polym Ed. 2008; 19:693–707.

10. conroy Jl, whitehouse sl, graves se, Pratt nl, ryan P, crawford rw. Risk factors for revision of early dislocation in total hip arthroplasty. J arthroplasty. 2008; 23:867–872.

11. davies mw, dunster kr, wilson k. gas exchange during perfluorocarbon liquid immersion. Life support for the ex utero fetus. Med Hypotheses. 2008; 71:91–8.

12. ekaputra a, Prestwich g, cool s, hutmacher d. combining electrospun scaffolds with electrosprayed hydrogels leads to three-dimensional cellularisation of hybrid constructs. Biomacromolecules. 2008; 9:2097–2103.

13. Fan w, crawford r, xiao Y. structural and cellular differences between metaphyseal and diaphyseal periosteum in different aged rats. Bone. 2008; 42:81–89.

14. gadomski a, Pawlak Z, Oloyede a. directed ion transport as virtual cause of some facilitated friction-lubrication mechanism prevailing in articular cartilage: A hypothesis. Tribology Letters. 2008; 30:83–90.

15. hay d, izatt m, adam c, labrom r, askin g. The use of fulcrum bending radiographs in anterior scoliosis correction: a consecutive series of 90 patients. Spine. 2008; 33:999–1005.

16. hutmacher d, Bowlin g. Nano-fiber scaffold science and tissue engineering. J Biomaterials Sci Polym Ed. 2008; 19:541–542.

17. hutmacher d, singh h. computational fluid dynamics for improved bioreactor design and 3d culture. Trends Biotechnol. 2008; 26:166–172.

18. krebs J, Ferguson s, hoerstrup s, goss B, haeberli a, aebli n. influence of bone marrow fat embolism on coagulation activation in an ovine model of vertebroplasty. J Bone Joint Surg Am. 2008; 90:349–356.

19. lam c, savalani m, Teoh s, hutmacher d. dynamics of in vitro polymer degradation of polycaprolactone-based scaffolds: accelerated versus simulated physiological conditions. Biomed Mater. 2008; 3:034108.

20. lee wcc, doocey Jm, Branemark r, adam, cJ, evans Jh, Pearcy mJ, Frossard la. fE stress analysis of the interface between the bone and an osseointegrated implant for amputees – implications to refine the rehabilitation programme. Clinical Biomechanics. 2008; 23:1243–50.

publications

p u b l i C a t i o n s [ 1 1 ]

21. little JP, Pearcy mJ, adam cJ. Are coupled rotations in the lumbar spine largely due to osseoligamentous anatomy? A modelling study. Computer Methods in Biomechanics and Biomedical Engineering. 2008; 11:95–103.

22. lutton c, goss B. caring about microenvironments. Nature Biotechnology. 2008; 26:613–614.

23. miao x. Modification of porous alumina ceramics with bioinert and bioactive glass coatings. Advanced Medicals Research. 2008; 32:211–214.

24. miao x, Tan dm, li J, xiao Y, crawford r. Mechanical and biological properties of hydroxyapatite/tricalcium phosphate scaffolds coated with poly(lactic-co-glycolic acid). Acta Biomater. 2008; 4:638–645.

25. Oloyede a, gudimetla P, chen a, crawford r. in vitro reversal of the load-bearing properties of lipid-depleted articular cartilage following exposure to phospholipid surfactant solutions. Clinical Biomech. 2008; 23:1200–1208.

26. Pawlak Z, crawford rw, Oloyede a. hypothetical model of hydrophilic lubrication in synovial joints. Australian Journal of Mechanical Engineering. 2008; 6:21–27.

27. Pawlak Z, kotynska J, Figaszewski Za, gadomski a, gudaniec a, Oloyede a. A biochemical model for characterising the surface-active phospholipid bilayer of articular cartilage relative to acid-base equilibrium. Archives of Material Science and Engineering. 2008; 29:24–29.

28. Pawlak Z, Oloyede a. conceptualisation of articular cartilage as a giant reverse micelle: A hypothetical mechanism for joint biocushioning and lubrication. Biosystems. 2008; 94:193–201

29. Pawlak Z, Pai r, Bayraktar e, kaldonski T, Oloyede a. Lamellar lubrication in vivo and vitro: friction testing of hexagonal boron nitrade. Biosystems. 2008; 94:202–208.

30. rider d, dombrowski c, sawyer a, ng g, leong d, hutmacher d, nurcombe v, cool s. Autocrine fibroblast growth factor 2 increases the multipotentiality of human adipose-derived mesenchymal stem cells. Stem Cells. 2008; 26:1598–1608.

31. schmutz B, reynolds k, slavotinek J. customisation of a generic 3d model of the distal femur using diagnostic radiographs. Journal of Medical Engineering and Technology. 2008; 32:156–161.

32. schmutz B, wullschleger me, kim h, noser h, schuetz ma. fit assessment of anatomical plates for the distal medial tibia. Journal of Orthopaedic Trauma. 2008; 22(4):258–263.

33. schuetz m. Australien: Trauma management in ‘down under’. Deutsche Gesellschaft für Unfallchirurgie – Mitteilungen und Nachrichten. 2008; 30:81–83.

34. schuetz m. clinical experience with locking plates – a review of the last decade. Japanese Society for Fracture Repair. 2008; 30:13:40–14:40

35. singh s, Jones BJ, crawford r, xiao Y. characterisation of a mesenchymal-like stem cell population from osteophyte tissue. Stem Cells and Development. 2008; 17:245–254.

36. Tan dmF, miao x, li l, xiao Y, crawford r. characterization of calcium phosphate cement-derived hydroxyapatite scaffolds with a PLgA-bioactive glass compositing coating. Journal of Biomimetics, Biomaterials and Tissue Engineering. 2008; 1:99–107.

37. wei x, wu l, ling J, liu l, liu s, liu w, li m, xiao Y. differentially expressed protein profile of human dental pulp cells in early process of odontoblast-like differentiation in vitro. Endondotics. 2008; 34:1077–1084.

38. whitehouse s, crawford r, learmonth i. validation for the reduced western Ontario and McMaster Universities Osteoarthritis index function scale. J Orthop Surg (Hong Kong). 2008; 16:50–53.

39. xiao Y, Peng h, mao x, whittaker a, crawford r. Novel synthetic bio-mimic polymers for cell delivery. Journal of Advanced Materials Research. 2008; 32:215–222.

40. Zeugolis d, khew s, Yew e, ekaputra a, Tong T, Yung l, hutmacher d, sheppard c, raghunath m. Electro-spinning of pure collagen nano-fibres – just an expensive way to make gelatine? Biomaterials. 2008; 29:2293–2305.

41. Zhao Y, sugiyama s, miao x. Nanoceramics for blood borne virus removal. Expert Review of Medical Devices. 2008; 5:395–405.

42. Zhou Y, hutmacher d, sai-lim v, Zhou Z, woodruff m, lim T. Osteogenic and adipogenic induction potential of human periodontol cells. J Periodontol. 2008; 79:524–534.

gUEsT EdiTORs

1. hutmacher dw, Bowlin gl. Foreword. Journal of Biomaterials Science, Polymer Edition, 2008; 19:541–2.

2. Pearcy mJ, adam cJ, Thompson r, wilcox r. guest editors for special issue current concepts and clinically significant outcomes of recent research into spinal mechanics. Proceedings of the Institution of Mechanical Engineers, Part H, Journal of Engineering in Medicine 2008; 222:1–248.

[ 1 2 ] p u b l i C a t i o n s

iNTERNATiONAL cONfERENcE PREsENTATiONs

1. chen g, Pearcy m, schuetz m, steck r. Numerical investigations of effects of plate fixation on nutrition supply to bone cortex. 54th Annual Meeting of the Orthopaedic Research Society. san Francisco, usa. 2–5 march 2008.

2. chen g, schmutz B, steck r, Pearcy m, wullschleger m, wilson c, schuetz m. Predicting the fatigue life of internal fracture fixation plates. 16th Congress of the European Society of Biomechanics. lucerne, switzerland. 6–9 July 2008

3. epari d. Experimental models of fracture repair. International Symposium 2008 Biomechanics and Biology of Bone Healing. Berlin, germany. 15–17 may 2008.

4. epari d, schell h, lineau J, duda g. intra-callus pressure and oxygen tension during normal bone healing in the sheep tibia. 54th Annual meeting of the Orthopaedic Research Society. san Francisco, usa. 2–5 march 2008.

5. gaddum n. Passive control of a Rotary Bivad; An experimental and numerical investigation. 16th Congress of the International Society for Rotary Blood Pumps. houston, Texas, 22–24 October 2008.

6. knippels i, kidd l, Forwood m, schuetz m, steck r. characterisation of rat ulna compression model using microcT and finite Element calculations. 11th Biennial Conference of the International Society for Fracture Repairs (ISFR). lake Tahoe, usa. 13–16 July 2008

7. little JP, adam cJ, evans Jh, askin gn, Pearcy mJ. Patient-specific soft tissue properties for Ais patients: a finite element study. 8th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering. Porto, Portugal 27 Feb–1 march 2008.

8. mcdonald k, little J, Pearcy m, adam cJ. Relative roles of cortical and trabecular thinning in reducing osteoporotic vertebral body stiffness: a modelling study. 13th International Conference on Biomedical Engineering. singapore. 3–6 december 2008.

9. mcdonald k, little JP, Pearcy mJ, adam cJ. Relative roles of cortical and trabecular thinning in reducing osteoporotic vertebral body stiffness: A modelling study. 13th International Conference on Biomedical Engineering (ICBME). singapore, 3–6 december 2008.

10. nijboer J, wullschleger m, nielsen s, mcnamee a, lefering r, ten duis h, schuetz m. Benchmarking trauma care performance of a tertiary hospital in Queensland to European Trauma centres: Using the german Trauma Registry as a model. German Conference for Orthopaedic and Trauma Surgery (DGU) Berlin, germany 22–25 October 2008.

11. noser h, heldstab T, schmutz B, kamer l. Accuracy and validation of processing steps for creating cT-based 3d Bone Models. Congress of Computer Assisted Radiography and Surgery (CARS2008). Barcelona, spain, 25–28 June 2008.

12. Pawlak Z, Pai r, Bayraktar e, kaldonski T, Oloyede a. Lamellar lubrication in vivo and vitro: friction testing of h-BN. 8th Asia-Pacific Conference on Materials Processing. Guilin-Guangzhou, china 15–20 June 2008.

13. schmutz B, volp a, momot k, schuetz ma. Using MRi for the imaging of long bones: first experiences. 16th Congress of the European Society of Biomechanics. lucerne, switzerland. 6–9 July 2008

14. steck r, gregory l, minehara h, wullschleger m, schuetz m. Three-dimensional visualisation of callus geometry in new murine fracture model. 11th Biennial Conference of the International Society for Fracture Repairs (ISFR). lake Tahoe, usa. 13–16 July 2008

15. shillington m, adam cJ, labrom rd, askin gn. A biomechanical investigation of anterior vertebral stapling. 13th International Conference on Biomedical Engineering (ICBME). singapore, 3–6 december 2008.

16. steck r, mcmillan d, goss B, rosenzweig n, schuetz m. Polymeric implant coatings with incorporated antibiotics inhibit bacterial growth and are scratch resistant. German Conference for Orthopaedic and Trauma Surgery (DGU). Berlin, germany. 22–25 October 2008.

17. sugiyama s. Effects of increased ambient temperature during ivM and/or ivf on the in vitro development of bovine zygotes. Royon International Twin Conference. Tehran, iran. 27–29 august 2008.

AUsTRALiAN/NEw ZEALANd cONfERENcE PREsENTATiONs

1. cordell-smith J, adam c, izatt m, labrom r, askin g. The effect of bone graft type on fusion rates following endoscopic anterior scoliosis correction. Spine Society of Australia Annual Scientific Meeting. adelaide, australia. 18–20 april 2008.

2. cordell-smith J, izatt m, adam c, labrom r, askin g. computed Tomography evaluation of axial vertebral derotation in endoscopic anterior instrumentation for scoliosis. Spine Society of Australia Annual Scientific Meeting. adelaide, australia. 18–20 april, 2008

p u b l i C a t i o n s [ 1 3 ]

3. goss B, lutton c, Young w, mackay-sim a, meedeniya a. Reduction of secondary degeneration after spinal cord injury by acute delivery of vascular growth factors. Spine Society of Australia Annual Scientific Meeting. adelaide, australia. april 2008

4. ibrahim s, chen g, schmutz B, mishra s, steck r, epari d, schuetz m. Relationship between configuration of screws and stress in an internal fracture fixation plate. 14th Annual Scientific Meeting, Australian and New Zealand Orthopaedic Research Society. Brisbane, australia. 17–18 november 2008.

5. izatt mT, adam cJ, labrom rd, askin gn. clinical aspects of endoscopic anterior scoliosis surgery. Adelaide Centre for Spinal Research – Spinal Research Symposium VI. adelaide, australia, 19–21 august 2008.

6. king B, wullschleger me, mishra s, schuetz ma, schmutz B. volumetric analysis of the space between bone surfaces and fracture fixation plates using 3d computer models. 14th Annual Scientific Meeting, Australian and New Zealand Orthopaedic Research Society. Brisbane, australia. 17–18 november 2008.

7. lee a, anderson P, sawker r, moore a, Forwood m, steck r, morris h, O’loughlin P. short-term vitamin d deficiency causes cancellous bone loss without changes to either cortical bone volume or mechanical strength in the rat tibia. 18th Annual Scientific Meeting of the ANZBMS. melbourne, australia. 28–30 august 2008.

8. little P, adam c. The effect of soft tissue stiffness on spinal flexibility: A finite element study. Spine Society of Australia Annual Scientific Meeting. adelaide, australia. 18–20 april, 2008.

9. mayo a, adam cJ, labrom rd, askin gn. A biomechanical study of top screw pullout in anterior scoliosis correction. 15th International Meeting on Advanced Spine Techniques (IMAST). hong kong, 8–11 July 2008.

10. mohd radzi s, rathnayaka k, Pratap J, mishra s, schuetz ma, schmutz B. The effects of cT convolution kernels on the geometry of 3d bone models. 14th Annual Scientific Meeting, Australian & New Zealand Orthopaedic Research Society. Brisbane, australia, 17–18 november 2008.

11. rathnayaka k, schmutz B, sahama T, schuetz m. Effects of image segmentation methods on the accuracy of long bone 3d reconstructions. 14th Annual Scientific Meeting, Australian and New Zealand Orthopaedic Research Society. Brisbane, australia. 17–18 november 2008.

12. shillington m, adam c, labrom r, askin g. The biomechanical effects of thoracic spine stapling. Spine Society of Australia Annual Scientific Meeting. adelaide, australia. 18–20 april 2008.

13. shillington m, adam cJ, labrom rd, askin gn. Anterior vertebral stapling for the fusionless correction of scoliosis: changes in motion segment stiffness following staple insertion and measurement of staple loading during movement. Australian and New Zealand Orthopaedic Research Society (ANZORS) 14th Annual Scientific Meeting. Brisbane, 16–21 november 2008.

14. schuetz m. development of a comprehensive trauma system in Queensland–benchmarking trauma care performance in a tertiary hospital in Queensland to European trauma centres. 68th Annual Scientific Meeting of the Australian Orthopaedic Association (AOA). hobart, australia. 12–15 October 2008.

15. schuetz m. Biomechanics of fracture healing–do we know how to treat simple fractures? 68th Annual Scientific Meeting of the Australian Orthopaedic Association (AOA). Hobart, Australia. 12–15 October 2008.

16. schuetz m. clinical experience with locking plates–a review of the last decade. 68th Annual Scientific Meeting of the Australian Orthopaedic Association (AOA). hobart, australia. 12–15 October 2008.

17. schuetz m. Animal injuries, horse kicks. Swan XVI Conference, Liverpool Hospital. sydney, australia. 25–26 July 2008.

18. schuetz m. Principals of locking plates and peri-articular plates. AOA-COE Conference. melbourne, australia. 6–8 august 2008.

19. schuetz m, epari d, chen g, schmutz B, steck r. Biomechanics of fracture healing. 5th Clare Valley Bone Meeting. adelaide, australia. 30 march–2 april 2008.

20. schmutz B, volp a, momot k, schuetz m. Using MRi for the imaging of long bones: first experiences. 14th Annual Scientific Meeting, Australian and New Zealand Orthopaedic Research Society. Brisbane, australia. 17–18 november 2008.

21. schmutz B, wullschleger m, steck r, schuetz m. Periarticular implants–Optimisation of plate design with computer modelling. 68th Annual Scientific Meeting of the Australian Orthopaedic Association (AOA). hobart, australia. 12–15 October.

22. shillington m, adam cJ, labrom rd, askin gn. The biomechanical effects of thoracic spine stapling. 15th International Meeting on Advanced Spine Techniques (IMAST). hong kong, 8–11 July 2008.

23. steck r, gregory l, minehara h, wullschleger m, schuetz m. Three dimensional visualisation of callus geometry in new murine fracture model. 14th Annual Scientific Meeting, Australian and New Zealand Orthopaedic Research Society. Brisbane, australia. 17–18 november 2008.

[ 1 4 ] p u b l i C a t i o n s

24. sugiyama s, goss B, wullschleger m, wilson k, williams r. Reliability of clinical measurement for assessing spinal fusion: an experimental sheep study. 14th Annual Scientific Meeting, Australian and New Zealand Orthopaedic Research Society. Brisbane, australia. 17–18 november 2008.

25. wullschleger m, schmutz B, ito k, steck r, schuetz m. Minimally invasive versus open plate osteosynthesis: Quantitative radiographic analysis of callus morphology of distal femur fractures in sheep using computed tomography imaging. 14th Annual Scientific Meeting, Australian and New Zealand Orthopaedic Research Society. Brisbane, australia. 17–18 november 2008.

26. wullschleger m, schmutz B, ito k, steck r, schuetz m. Minimally invasive plate osteosynthesis: Quantitative analysis of callus formation in a distal femur fracture model in sheep using computed tomography imaging. 68th Annual Scientific Meeting of the Australian Orthopaedic Association (AOA). hobart, australia. 12–15 October 2008.

27. wullschleger m, neilsen s, nijboer a, mcnamee a, lefering r, schuetz m. secondary referred trauma patients: comparison to those with primary admissions to a tertiary hospital in south-East Queensland. Swan XVI Conference, Liverpool Hospital. sydney, australia. 25–26 July 2008.

28. wullschleger m, steck r, wilson k, ito k, schuetz m. Minimally invasive plate osteosynthesis: Advanced early fracture healing in an ovine trauma model. 68th Annual Scientific Meeting of the Australian Orthopaedic Association (AOA). hobart, australia. 12–15 October 2008.

gUEsT PREsENTATiONs

Orthopaedics and Trauma Queensland

wishes to thank our visiting guest

presenters for 2008:

› Professor saso ivanovski, chair of Periodontology at griffith university.

› dr hans de visser, australian e-health research centre, csirO

› dr andrew ward, intellidesign. › anne Trimmer, chief executive Officer,

medical Technology association of australia.

› associate Professor nigel morrison, school of medical sciences, griffith university

› dr mark gillies, worley Parsons › Professor stephan Perren and

nicholas Perren

s t a f f [ 1 5 ]

NAME TiTLE

AO BRisBANE sPiNE gROUP

dr richard williams centre director

dr Ben goss research Fellow

dr sadahiro sugiyama research Fellow

dr con vasili clinical Fellow

dr alexander gibson clinical Fellow

ms sanela stanojevic research assistant

ms rachel luton-goggins administration coordinator

MEdicAL ENgiNEERiNg

Professor mark Pearcy Professor of Biomedical engineering medical device domain leadermedical engineering Theme leader

Professor John evans adjunct Professor

associate Professor xigeng (simon) miao associate Professor

dr sanjay mishra senior lecturer

ms deborah whiting research Theme coordinator

mr keith Officer merF Operations manager

ms carmel Johnson merF administrative Officer

mr James kelly anatomical skills laboratory manager, merF

mr greg Tevelen supervising Technician/dry laboratory manager

dr kathleen wilson Biological research Facility manager, merF

mr david mcintosh Technician, merF

mr ian mellor cadaveric assistant, merF

mr michael lindeberg Biological research Facility attendant, merF

mr Peter lindeberg Biological research Facility attendant, merF

mr Bill sommers Biological research Facility attendant, merF

mr kimble dunster research associate

ms shobha mareddy research assistant

dr mark davies visiting Fellow

dr John Fraser visiting Fellow

dr andreas schibler visiting Fellow

NORThsidE sPiNAL REsEARch gROUP

dr Paul licina spinal Orthopaedic surgeon

ms carmen sutton research assistant

ORThOPAEdic REsEARch gROUP

Professor ross crawford chair in Orthopaedic research

Professor kunle Oloyede leader, cartilage Biomechanics group

associate Professor Yin xiao leader, Bone Biology group

dr cameron lutton Postdoctoral research Fellow

dr Yufeng Zhang Postdoctoral Fellow

dr lance wilson research Fellow

dr sarah whitehouse research Fellow

dr ngiem doan visiting Fellow

dr Tim Barker visiting Fellow

staff

[ 1 6 ] s t a f f

dr Ying Zheng visiting Fellow

dr corey richards visiting Fellow

dr Juju (chewy) Joseph visiting Fellow

ms louise hood clinical data manager

ms sue grice clinical research nurse

mr Thor Friis research assistant

ms wei shi research assistant

mr cameron Brown research assistant

mr darcy hinde research assistant

ms Jane wiseman Personal assistant

PAEdiATRic sPiNE REsEARch gROUP

dr geoff askin spinal Orthopaedic surgeon

associate Professor clayton adam Principal research Fellow

dr James cordell-smith clinical Fellow

dr robert labrom spinal Orthopaedic surgeon

dr Paige little Postdoctoral research Fellow

dr matthew shaw clinical Fellow

dr mark shillington clinical researcher

mrs maree izatt senior research assistant

REgENERATivE MEdiciNE gROUP

Professor dietmar hutmacher chair in regenerative medicine

dr Travis klein Postdoctoral research Fellow

dr maria woodruff Postdoctoral research Fellow

dr Johannes reichert research Fellow

dr siamak saifzadeh research Fellow

dr Paul dalton research Fellow

ms verena Quent research assistant

ms victoria Taverner Personal assistant

TRAUMA REsEARch gROUP

Professor michael schuetz chair in Trauma

Professor lutz claes adjunct Professor

Professor norbert haas adjunct Professor

Professor stephan Perren adjunct Professor

dr roland steck senior research Fellow

dr devakara epari senior research Fellow

dr Beat schmutz senior research Fellow

dr gongfa chen Post doctoral research Fellow

dr herwig drobetz visiting research Fellow

dr david mcmillan visiting research Fellow

ms salma ibrahim research assistant

ms caroline grant research assistant

ms natalie rosenzweig research assistant

mrs rebecca Bibby executive support Officer

mrs caryll clifford executive support Officer

a d j u n C t p R o f e s s o R i a l s t a f f [ 1 7 ]

› dr geOFFreY askin

› PrOFessOr luTZ claes

› dr Bill dOnnellY

› dr JOhn earwaker

› PrOFessOr JOhn evans

› PrOFessOr nOrBerT haas

› dr Paul licina

› PrOFessOr sTePhan Perren

› dr richard williams

Finite element simulations: (top) of a rat ulna compression model, which is used for studying stress fracture healing; (bottom) to predict correctly the location of the stress fracture.

adjunct professorial staff

[ 1 8 ] H i g H e R d e g R e e R e s e a R C H s t u d e n t s

Higher degree research students

NEw sTUdENTs

doctor of Philosophy

NAME dETAiLs

krishnakanth, Pushpanjali characterisation of fracture stabilization device variables by analytical and finite element models

kuaha, kunikka characterization of adult mesenchymal stem cells derived from perivascular umbilical cord and investigating the potential use for regeneration of cartilage

Quent, verena application of a human bone engineering platform to an in vitro and in vivo prostate and breast cancer model

grant, caroline understanding the biomechanical effects of fixation strategies to improve the technology of fracture management

Toal, victoria The mechanics of microdamage and microfracture in trabecular bone

rathnayaka, kanchana magnetic resonance imaging (mri) of long bones

chun, Ju Ok (June) engineering articular cartilage with zonal structure and function

irawan, daisy Functionalised gellan gum for cartilage regeneration

sin, dong choon (daniel) Porous coating on titanium substrate for the growth of an endothelial layer

clemens, stephan a reference process model for multi-trauma patients

Master of Engineering

NAME dETAiLs

roe, John geometry and stability of tapered femoral stems in bone cement

ibrahim, salma application of optimisation methods for improving screw configurations in bone fracture plate fixation

Thomas, dr chris determinants of internal fixation stability and fracture healing

cONTiNUiNg sTUdENTs

doctor of Philosophy

NAME dETAiLs

kaur, navdeep identification and characterization of the molecular signatures of the mesenchymal stem cell

afara, isaac development of the smarthroscope for surgical assessment and treatment decisions

lai, chun-chih Frank aFm study of mesenchymal stem cells on biomaterials

reichert, dr Johannes reconstruction of critical sized segmented bone defects in a large animal model

shiu, hoi Ting Prothrombogenic bone grafts

Prasadam, indira Osteoblast and chondrocyte interactions in osteoarthritis

Yusuf, kehinde modelling of transport process in normal and degenerate articular cartilage with specific reference to the action of phospholipid surfactants

cunningham, helen an experimental and finite element investigation of the biomechanical outcomes of scoliosis correction surgery.

duong, Quang Thien development of a structural model of articular cartilage: an experimental and visualisation study

Fan, wei Periosteum tissue engineering and its in vivo application in bone defect healing

wullschleger, martin effect of surgical approach on bone vascularisation, fracture and soft tissue healing: comparison of less invasive and open surgical approach

mcdonald, katrina an experimental and finite element investigation of the biomechanical outcomes of vertebral compression fracture

watts, mark charles Forces at the tendon bone interface in reconstructive surgery

H i g H e R d e g R e e R e s e a R C H s t u d e n t s [ 1 9 ]

cairns, nicola The feasibility of vibration analysis as a technique to detect osseointegration of transfemoral implants

Young, Yun wai (will) secondary therapies for spinal cord regeneration

sieh, shirly development of a three dimensional culture system to study the skeletal metastasis of Prostate cancer (caP)

liu, gang The guided differentiation of bone marrow mesenchymal stem cells into bone-cartilage neotissue for osteochondral tissue engineering

Master of Engineering

NAME dETAiLs

Beldiman, monica assessment of the effectiveness and safety of lipid-based joint remedial formulation in-vitro

couzens, gregory a testing rig to measure forces across the cadaver wrist under physiological loading

shillington, mark Biomechanics of shape memory alloy staples for fusionless correction of scoliosis

sattar, imran development of a portable 3d profiling device for cim of customised medical seats

cOMPLETiONs

doctor of Philosophy

NAME dETAiLs

mareddy, shobha single cell derived clones of bone marrow stromal cells from osteoarthritis patients: molecular and cellular characterisation

Brown, cameron development and synthesis of innovative approaches to the surgical assessment of articular cartilage degeneration

sanjleena singh separation and characterization of multipotent cells from osteophytes in osteoarthritis.

gale, lorne Biotribological assessment of artificial synovial joints: the role of boundary lubrication

cargill, sara clare Biomechanical modelling of the lumbopelvic musculoskeletal system in sitting and standing

Master of Engineering

NAME dETAiLs

mayo, andrew an experimental investigation of the mechanics of vertebral body screws used in spinal deformity surgery

OvERsEAs visiTiNg sTUdENTs

NAME UNivERsiTy

ingrid knippels radboud university, The netherlands

armand Tillie radboud university, The netherlands

lianne de kleijn radboud university, The netherlands

lu liu sun Yat-sen university, china

wei Fang wuhan university, china

Bart rijckaerts Twente university, The netherlands

saskia wilting radboud university, The netherlands

anne van eijk radboud university, The netherlands

eleonora carletti university of Trento, italy

claudia schaar FhTw university of applied sciences

mark stamer Technical university hamburg-harburg, germany

klaus michael uhr Technical university hamburg-harburg, germany

[ 2 0 ] a w a R d s , p R i z e s a n d C o m m u n i t y s e R v i C e

awards, prizes and community service

› mark Pearcy was presented with the international conference on Biomedical engineering (icBme) honorary distinguished award at this year’s 13th icBme. This award was to recognise his distinguished contributions in the field of biomedical engineering and in particular for his continued strong support of the icBme series of conferences over the years

› Ben goss, cameron lutton and will Young from QuT, together with alan mackay-sim and adrian meedeniya from griffith university were awarded the spine society of australia (ssa) research award for 2008 at the annual scientific meeting of the ssa in adelaide in april 2008, for their paper: ‘reduction of secondary degeneration after spinal cord injury by acute delivery of vascular growth factors’.

This is a prestigious award and is awarded following submission of a full, journal length paper, before the ssa’s annual scientific meeting. The papers are reviewed by the three members of the scientific committee prior to the meeting. This year there were 11 papers submitted all of which were deemed to be of a high standard. The award recognised that the paper was an excellent presentation of innovative, exciting and well conducted research. Ben also presented a well received account of the research at the meeting which prompted considerable discussion.

› dr Ben goss was runner up in the Queensland Premier’s awards for health and medical research – senior researcher award

› victoria Toal (Phd student) commenced her studies in march 2008 on ‘The mechanics of microdamage and microfracture in trabecular bone’. her outstanding academic performance ensured she received a prestigious smart state Phd scholarship. victoria was also selected to attend the ‘Brightest Young minds’ summit in sydney in July and was a finalist in the ‘smart women’s, smart state awards’, held in september. her work aims to increase understanding of how damage occurs in our bones at the microstructural level under different loading conditions. such damage is present in all bones, but is of greater concern for those who have weaker bones due to disorders such as osteoporosis. victoria aims to achieve her goals using experimental methods as well as computer modelling.

› ingrid knippels, a visiting student from radboud university in nijmegen, The netherlands, and roland steck were awarded the ‘Best basic science poster’ award at the meeting of the int. society for Fracture repair in south lake Tahoe, nv (13–16 July 2008) for the paper by i knippels, l kidd and m Forwood (both university of Queensland), m schuetz, and r steck on: ‘characterisation of the rat ulna compression model using microcT and Finite element calculations’.

› Prof michael schuetz was invited as the racs Foundation visitor to the annual australian Orthopaedic meeting in hobart/October 2008.

› acknOwledgemenTs

Orthopaedics and Trauma Queensland gratefully

acknowledges the significant financial and

collaborative support of:

› aO Foundation

› australian research council

› dePuy spine

› golden casket research Foundation

› holy spirit northside hospital

› institute of health and Biomedical innovation

› mater Foundation

› mater health services Brisbane ltd

› medtronic sofamor danek

› national health and medical research council

› Princess alexandra hospital

› Queensland health

› Queensland Orthopaedic research Trust

› Queensland university of Technology

› Queensland x-ray

› royal australasian college of surgeons

› synthes

› stryker

› The Prince charles hospital

› The Prince charles hospital Foundation

› The wesley research institute

© QuT 2009 Produced by QuT Publications 16039 cricOs no. 00213J