ORAL LESION Prof. Hesham Saad. Objectives Inflammatory & reactive conditions - Candidiasis - Herpes...
-
Upload
britney-mills -
Category
Documents
-
view
221 -
download
4
Transcript of ORAL LESION Prof. Hesham Saad. Objectives Inflammatory & reactive conditions - Candidiasis - Herpes...
ORAL LESIONProf. Hesham Saad
ObjectivesInflammatory & reactive conditions• - Candidiasis - Herpes simplex • - Aphthous ulcer - Pyogenic granuloma• - EpulisPrecancerous & Malignant lesions• - Leukoplakia & Erythroplakia• - Squamous cell carcinomaSalivary glands diseases• - Sialadenitis• - Tumors of salivary glands
Inflammatory & reactive conditions
• Fungal (Candidiasis) :Candida albicans , (thrush, moniliasis), adherent white, circumscribed plaque anywhere within the oral cavity
• Viral (Herpes simplex): (HSV) type 1, vesicles and ulcers, intracellular edema.
• Aphthous ulcer: painful shallow ulcers with red rim
Candida albicans infection of the palate
Aphthous ulcer : shallow ulcers
Inflammatory & reactive conditions
• Pyogenic granuloma: after trauma, proliferating capillaries, edema , inflammatory infiltrate
• Epulis (prepheral giant cell granuloma): Aggregate of foreign body like giant cells separated by fibroangiomatous stroma
Pyogenic granuloma ulcerated
Pyogenic granuloma
Precancerous & Malignant oral cavity lesions • Leukoplakia : whitish, well-defined mucosal patch
or plaque caused by epidermal thickening , hyperkeratosis with various degree of dysplasia
• Erythroplakia: red, velvety, granular, circumscribed areas may or may not be elevated, poorly defined, irregular boundaries, marked dysplasia
• Squamous cell carcinoma : moderately to well-differentiated keratinizing tumors. Predisposing factors: leukoplakia, erythroplakia, smoking , HPV, trauma, alcohol
Leukoplakia of the tongue in a smoker. Microscopically, this lesion showed severe dysplasia with transformation to squamous cell carcinoma in the posterior elevated portion
Salivary glands diseases
Sialadenitis : Inflammation of the major salivary glands may be
- Viral (mumps) : diffuse, interstitial inflammation marked by edema
- Bacterial : * Acute : obstruction or retrograde entry of oral cavity bacteria ,
(interstitial, focal suppurative necrosis or abscess formation) * Chronic sialadenitis arises from decreased production of saliva with
subsequent inflammation- Autoimmune : bilateral, (Sjögren syndrome) , All of the salivary
glands & lacrimal glands
Salivary gland : Sjogren’s syndrome ( destroyed acini, lymphoid infiltrate, fibrous stroma)
Tumors of salivary glands
• Males and females are affected equally• sixth or seventh decade of life• Distribution– Parotid: 80% overall; 80% benign– Submandibular: 15% overall; 50% benign– Sublingual/Minor: 5% overall; 40% benign
• 70% to 80% of all tumors are benign
Tumors of salivary glands BENIGN• Pleomorphic adenoma• Monomorphic adenoma• Papillary cystadenoma• Oncocytoma
MALIGNANT• Mucoepidermoid carcinoma.• Adenoid cystic carcinoma• Acinic cell carcinoma• Adenocarcinomas
Tumors of salivary glands BENIGN• Pleomorphic adenoma (mixed tumor) is the commonest
(90% of benign tumors of the salivary glands)• Cystadenoma lymphomatosum (Warthin tumor) small, well-encapsulated , epithelial layer lining cleft like
spaces ,well-developed lymphoid tissue MALIGNANT• Malignant mixed tumors : Carcinoma developing in the
epithelial component of preexisting pleomorphic adenoma
• parotid gland (15%), submandibular glands (40%)• Mucoepidermoid carcinoma : only in the region of the
parotid (adenocarcinomatous and squamous cell carcinomatous features)
Pleomorphic adenoma
Warthin tumor (Cystadenolymphoma) : epithelial layer
lining cleft like spaces ,well-developed lymphoid tissue
Mucoepidermoid Carcinoma : (Atypical squamous cells with eosinophilic cytoplasm and very large nuclei with prominent nucleoli , within the group there are also several small cysts contain mucin)
Mucoepidermoid Carcinoma
• Histology—Low-grade– Mucus cell > epidermoid cells
• Histology—Intermediate- grade– Mucus = epidermoid
• Histology—High-grade– Epidermoid > mucus