OPIOIDS/ ANALGESICS CATHINONES · 5-EAPB 4-APB 5-APDB 6-APB Benzofuran Iden fica ons Piperazine...
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EMERGING THREAT REPORT 2016 Drug Enforcement Administra�on Special Testing and Research Laboratory U S D e p a rt m e n t o f . . J u s tic e D ru g E nfo rc e m e nt A dm in ist r a t i o n . Annual FOR OFFICIAL USE ONLY CATHINONES The Special Tes�ng and Research Laboratory’s Emerging Trends Program compiled the data for this report through a query of archived seizure and analysis informa�on from drug evidence analyzed by the Drug Enforcement Administra�on’s laboratory system. This data is representa�ve of drug evidence seized and analyzed in the date ranges annotated. This is not a comprehensive list of all new psychoac�ve substances and is not representative of all evidence analyzed by DEA. This data presents an annual summary of the new psychoactive substance market in the United States. The term new psychoactive substance (NPS) describes a recently emerged drug that may pose a public health threat. This includes synthetic cannabinoids, substituted cathinones, phenethylamines, opioids, tryptamines, benzodiazepines, and a variety of other chemical classes. Due to the recent increase in seizures, fentanyl and related compounds are also included in this report. Summary FUB-AMB and 5F-UR-144 were the most commonly reported synthe�c cannabinoids. Dibutylone and ethylone were the most commonly reported cathinones. There were 21 substances reported for the first time in CY 2016, meaning they have not been encountered for at least the last two years. This equates to one new substance approximately every two and a half weeks. It should be noted that as backlogged samples are analyzed, the date of the first encounter may change. Most notably, 60% of the opioids iden�fied in CY 2016 were iden�fied for the first �me in CY 2016. THERE WERE 347 CATHINONE IDENTIFICATIONS IN CY 2016. DIBUTYLONE ACCOUNTED FOR APPROXIMATELY 22% OF THE IDENTIFICATIONS. Of the 24 substances iden�fied, five of these substances (~20%) were reported for the first �me in 2016. The following compounds were seized and reported for the first �me in 2016: 4-CEC, 3-CMC, 3-MEC, 4-fluoro-α-PHP, and 4- methoxy-α-PV8. 78 63 57 44 18 16 13 11 10 6 6 4 4 3 2 2 2 2 1 1 1 1 1 1 Dibutylone Ethylone N-Ethylpentylone α-PVP Pentylone TH-PVP 4-Cl-α-PVP 4-Cl-α-PPP Methylone 4-CMC Dimethylone 4-CEC N-Ethyl-4-methylnorpentedrone 3-CMC 3,4-MDPV 4 F-α-PVP 4-F-α-PHP 4-FMC 4-BMC 3-MEC PV8 4 -MEC 3,4 -Methylenedioxy-α-PBP 4-Methoxy-α-PV8 OPIOIDS/ ANALGESICS THERE WERE 1299 IDENTIFICATIONS OF FENTANYL, FENTANYL-RELATED SUBSTANCES, AND OTHER NEW OPIOIDS. FENTANYL ACCOUNTED FOR APPROXIMATELY 68% OF THE IDENTIFICATIONS. THE NEXT MOST PROMINENT OPIOID, FURANYL FENTANYL, ACCOUNTED FOR 11% OF THE IDENTIFICATIONS. Of the 877 fentanyl iden�fica�ons, f entanyl was found as the only controlled substance in 46.5% of the iden�fic a�ons and was found in combination with heroin in approximately 42% of the iden�fica�ons. Other controlled substances r ou�nely seen with fentanyl include heroin, methamphetamine, cocaine, alprazolam, and fentanyl-related compounds. Furanyl fentanyl replaced acetylfentanyl as the second most prominent fentanyl-related substance during the second quarter of 2016. U - 4- 47700 ANPP 142 112 877 50 32 20 17 13 13 10 4 3 3 2 1 Fentanyl Furanyl fentanyl Acetylfentanyl - 4 Fluoroisobutyrylfentanyl Carfentanil Acryl fentanyl Butyryl fentanyl Valerylfentanyl o-Fluorofentanyl Benzylfentanyl p-Fluorobutyrylfentanyl 3-Methylfentanyl Acetyl norfentanyl An identification is made when authenticated reference material is available for comparison. When reference material is not available, the drug evidence is identified as “substance unconfirmed.” A single unit of drug evidence may have mul�ple sub-units. For the purposes of this document, each unit of drug evidence counts as one iden�fica�on regardless of the number of sub-units. Some seized drug evidence contains more than one ac�ve ingredient; therefore, more than one iden�fica�on can be made for a single unit. Of the 15 substances iden�fied, nine of these substances (60%) were reported for the first �me in 2016. The following compounds were seized and reported for the first �me in 2016: furanyl fentanyl, U-47700, 4-fluoroisobutyryl- fentanyl, acryl fentanyl, o-fluorofentanyl, benzylfentanyl, p-fluorobutyrylfentanyl, 3-methylfentanyl, and acetyl norfentanyl. FMC = Fluoromethcathinone BMC = Bromomethcathinone MEC = Methylethcathinone CMC = Chloromethcathinone CEC = Chloroethcathinone PV8 = Pyrrolidinoheptanone Together, NPS, fentanyl, and fentanyl-related compounds account for 8% of the exhibits seized in 2016 and analyzed by the DEA laboratory system in 2016. Fentanyl and furanyl fentanyl were the most commonly reported opioids.
Transcript of OPIOIDS/ ANALGESICS CATHINONES · 5-EAPB 4-APB 5-APDB 6-APB Benzofuran Iden fica ons Piperazine...
EMERGING THREAT REPORT 2016 Drug Enforcement Administra�onSpecial Testing and Research Laboratory
US Department of. . Justice
Drug Enforcement Admini
stra
tion
.
Annual
FOR OFFICIAL USE ONLY
CATHINONES
The Special Tes�ng and Research Laboratory’s Emerging Trends Program compiled the data for this report through a query of archived seizure and analysis informa�on from drug evidence analyzed by the Drug Enforcement Administra�on’s laboratory system. This data is representa�ve of drug evidence seized and analyzed in the date ranges annotated. This is not a comprehensive list of all new psychoac�ve substances and is not representative of all evidence analyzed by DEA. This data presents an annual summary of the new psychoactive substance market in the United States.
The term new psychoactive substance (NPS) describes a recently emerged drug that may pose a public health threat. This includes synthetic cannabinoids, substituted cathinones, phenethylamines, opioids, tryptamines, benzodiazepines, and a variety of other chemical classes. Due to the recent increase in seizures, fentanyl and related compounds are also included in this report.
Summary
FUB-AMB and 5F-UR-144 were the most commonly reported synthe�c cannabinoids.
Dibutylone and ethylone were the most commonly reported cathinones.
There were 21 substances reported for the first time in CY 2016, meaning they have not been encountered for at least the last two years. This equates to one new substance approximately every two and a half weeks. It should be noted that as backlogged samples are analyzed, the date of the first encounter may change.
Most notably, 60% of the opioids iden�fied in CY 2016 were iden�fied for the first �me in CY 2016.
THERE WERE 347 CATHINONE IDENTIFICATIONS IN CY 2016.
DIBUTYLONE ACCOUNTED FOR APPROXIMATELY 22%OF THE IDENTIFICATIONS. Of the 24 substances iden�fied, five of
these substances (~20%) were reported for the first �me in 2016. The following compounds were seized and reported for the first �me in 2016: 4-CEC, 3-CMC, 3-MEC, 4-fluoro-α-PHP, and 4-methoxy-α-PV8.
7863
5744
1816
1311
1066
44
32222
111111
DibutyloneEthylone
N-Ethylpentyloneα-PVP
PentyloneTH-PVP
4-Cl-α-PVP4-Cl-α-PPPMethylone
4-CMCDimethylone
4-CECN-Ethyl-4-methylnorpentedrone
3-CMC3,4-MDPV
4 F-α-PVP4-F-α-PHP
4-FMC4-BMC3-MEC
PV84 -MEC
3,4 -Methylenedioxy-α-PBP
4-Methoxy-α-PV8
OPIOIDS/ANALGESICS
THERE WERE 1299 IDENTIFICATIONS OF FENTANYL, FENTANYL-RELATED SUBSTANCES, AND OTHER NEW OPIOIDS. FENTANYL ACCOUNTED FOR APPROXIMATELY 68% OF THE IDENTIFICATIONS. THE NEXT MOST PROMINENT OPIOID, FURANYL FENTANYL, ACCOUNTED FOR 11% OF THE IDENTIFICATIONS. Of the
877 fentanyl iden�fica�ons, fentanyl was found as the only controlled
substance in 46.5% of the iden�fica�ons and was found in combination
with heroin in approximately 42% of the iden�fica�ons. Other controlled substances rou�nely seen with fentanyl include heroin, methamphetamine, cocaine, alprazolam, and fentanyl-related compounds. Furanyl fentanyl replaced acetylfentanyl as the second most prominent fentanyl-related substance during the second quarter of 2016.
U
-
4-
47700
ANPP
142112
877
5032
201713131043321
Fentanyl
Furanyl fentanyl
Acetylfentanyl
-
4
Fluoroisobutyrylfentanyl
Carfentanil
Acryl fentanyl
Butyryl fentanyl
Valerylfentanyl
o-Fluorofentanyl
Benzylfentanyl
p-Fluorobutyrylfentanyl
3-Methylfentanyl
Acetyl norfentanyl
An identification is made when authenticated reference material is available for comparison. When reference material is not available, the drug evidence is identified as “substance unconfirmed.” A single unit of drug evidence may have mul�ple sub-units. For the purposes of this document, each unit of drug evidence counts as one iden�fica�on regardless of the number of sub-units. Some seized drug evidence contains more than one ac�ve ingredient; therefore, more than one iden�fica�on can be made for a single unit.
Of the 15 substances iden�fied, nine of
these substances (60%) were
reported for the first �me in 2016. The following compounds were seized and reported for the first �me in 2016: furanyl fentanyl, U-47700, 4-fluoroisobutyryl-fentanyl, acryl fentanyl, o-fluorofentanyl, benzylfentanyl, p-fluorobutyrylfentanyl, 3-methylfentanyl, and acetyl norfentanyl.
FMC = Fluoromethcathinone BMC = Bromomethcathinone MEC = Methylethcathinone CMC = Chlorome thcathinone CEC = ChloroethcathinonePV8 = Pyrrolidinoheptanone
Together, NPS, fentanyl, and fentanyl-related compounds account for 8% of the exhibits seized in 2016 and analyzed by the DEA laboratory system in 2016.
Fentanyl and furanyl fentanyl were the most commonly reported opioids.
Questions about this data are welcome and may be directed to the DEA Emerging
Trends Program at 703-668-3300 or [email protected]
10
7
2
N- BZP
TFMPP
pFPP
MBZP
6
1
1
1
5-EAPB
4-APB
5-APDB
6-APBBenzofuran Iden�fica�ons
Piperazine Iden�fica�ons
EMERGING THREAT REPORT 2016 Drug Enforcement Administra�onSpecial Testing and Research Laboratory
US Department of. . Justice
Drug Enforcement Admini
stra
tion
.
Annual (continued)
FOR OFFICIAL USE ONLY
There were 3 iden�fica�ons of 25I-NBOMe, 1iden�fica�on of 25C-NBOMe, and 1 iden�fica�on
of 2C-B during the repor�ng period.
HALLUCINOGENSOTHER
SYNTHETICCANNABINOIDS
222122
87
79
49
4040
3331
2514
111010
776655
333
33221111111
5
MAB-CHMINACA = ADB-CHMINACA
There were 3 iden�fica�ons of 5-MeO-DiPT and 1
iden�fica�on of 5-MeO-MiPT during the repor�ng period.
TRYPTAMINES
THERE WERE 43 INSTANCES OF UNCONFIRMED SUBSTANCES
DURING THIS REPORTING PERIOD. There were 4 benzofurans
and 4 piperazines reported in CY 2016. Additionally, there
were 9 identifications of mitragynine, 8 identifications of
deschloroketamine, 3 identifications each of
3-fluorophenmetrazine and 4-fluoroamphetamine, 2 identifications each of MDMA methylene homolog,
methoxetamine (MXE), and W-18, and 1 identification eachof ethylphenidate, MDPT (tBuONE), and N-ethyl-N-methyl-1,2-diphenylethan 1-amine.
The following compounds were seized and reported for the first time in 2016: 5-EAPB, 3-fluorophenmetrazine, MDPT (tBuONE), and N-ethyl-N-methyl-1,2-diphenylethan-1-amine.
THERE WERE 984 SYNTHETIC CANNABINOID IDENTIFICATIONS IN
CY 2016. FUB-AMB AND 5F-UR-144 WERE THE MOST COMMONLY
REPORTED SYNTHETIC CANNABINOIDS, ACCOUNTING FOR APPROXIMATELY 34% OF THE SYNTHETIC CANNABINOID
IDENTIFICATIONS DURING THE REPORTING PERIOD. Of the 37 different synthe�c cannabinoids iden�fied, three (~8%) of these substances, PX-2, MMB-CHMICA, and AB-CHMICA, were seized and reported forthe first �me in 2016.
FUB -5F - UR-144
5F - -MDMB
MDMB
PINACAAB - CHMINACA
5F - AMB
AMB
AB - FUBINACAMAB - CHMINACA
AB - PINACAFUB - PB - 22
NM2201- FUBINACA
PB - 22MMB - CHMICA
JWH - 0185F - AB- PINACA
ADB- FUBINACA5F PB-- 22SDB - 005
MAM2201THJ - 2201
FUB - AKB48JWH - 073
PX -5F - NPB
2
AB - CHMICA
CHMICA
FUB - 144JWH - 019JWH -250AM2201
JWH - 1225F - AKB48
ADB - PINACAAPP -
FDU - PB 22FUBIMINAJWH 081
UR --
144
-
80
64
The "other" category includes substances that could not be confirmed, psychoactive plants, PCP-related substances, benzofurans, benzodiazepines, piperizines, and amphetamines.
This completes the 2016 series of reports.
Stay tuned for the First Quarter 2017 Emerging Threat Report!
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