October 22, 2013 View Online | Subscribe | Unsubscribe

For our readers: Due to staff attending the UNION meeting in Paris, there will be a one week delay in the

release of the next TB Wire, on November 11th.

The US Government shut down affected some of the news sources that we use to put together this TB Wire.

As the shutdown has ended, we will be able to resume including that information in the future.

Please feel free to forward the TB Wire to others who may be interested. If the file is too large to send, you

can refer others to Stop TB USA SIGN UP where they can sign up to receive it (and other Stop TB USA

communications) directly. The Stop TB USA Facebook link is now available on the header above and Stop TB

USA is now on twitter as well. https://twitter.com/StopTBUSA . As always, suggestions and comments are

welcome and appreciated at setkind@stoptbusa.org.

WASHINGTON UPDATE

Thanks to Nuala Moore for the following updated information. Nuala is the Senior Legislative Representative

at the American Thoracic Society Washington Office.

Domestic TB Funding Update

On October 16, a deal was finalized between the House, Senate and President Obama that reopened federal

government agencies and increased the debt ceiling. The agreement funds government programs at current

funding levels through January 15, 2014 and raises the debt ceiling until February 7, 2014. The measure also

requires additional income verification for individuals receiving health insurance subsidies provided through

the Affordable Care Act's health insurance exchanges and back pay for federal employees furloughed during

the two week government shutdown.

The agreement also created a bicameral conference committee to determine final FY2014 spending and other

budget issues by a new deadline of December 13, 2013. This committee, co-chaired by the House and Senate

Budget committee chairs, Sen. Murray (D-WA) and Rep. Ryan (R-WI), is tasked with determining whether

budget sequestration funding cuts will be implemented in FY2014. If a new plan is not produced by this

committee by December 13, budget sequestration funding cuts of 5 - 7% will be implemented across the

board to all federal agencies, including the NIH and CDC, on January 15, 2014, with the exception of the

Veterans Dept. and some safety net programs such as food stamps.

ANNOUNCEMENTS

FROM THE CDC

New Exhibition: "Health Is a Human Right: Race and Place in America" Open: September 28, 2013 - January 17,

2014

The David J. Sencer CDC Museum in Atlanta, with support from the Centers for Disease Control and Prevention

and the California Endowment, is hosting an important exhibit that looks at race and place in America and its

links to health disparities. You can visit the exhibit any week day throughout its duration. It will be open until

January 17, 2014.

The AAAS Science & Technology Policy Fellowship opportunity:

The AAAS Science & Technology Policy Fellowships® is a public service and professional development

opportunity to learn first-hand about the intersection of science and policy. Fellows serve yearlong

assignments in congressional offices and federal agencies (NIH, USAID, DoE, etc) in the Washington, D.C.

region. To view a list of all six program areas click here.

The deadline to apply to the 2014-2015 AAAS Science & Technology Policy Fellowship class is less than a

month away. Join a network of more than 2,800 current and alumni fellows impacting policy and forging new

careers! Stipends range from approximately $74,000 to $99,000. Other benefits include health insurance,

travel/training allowance and relocation allocation. For more information about benefits, visit

http://fellowships.aaas.org/05_Support/05_index.shtml . The deadline for applications is November 1, 2013,

5:00 p.m. Eastern Standard Time. Apply at https://fellowshipapp.aaas.org/ Applicants must hold a doctoral

level degree (PhD, MD, DVM, etc.), in any of the following: Social/Behavioral sciences;- Medical/Health

disciplines;- Biological, Physical or Earth sciences;- Computational sciences and Mathematics;- Engineering

disciplines (applicants with a master's degree and three years of experience also qualify). All degree

requirements must be completed by the application deadline.

Visit http://fellowships.aaas.org/04_Become/04_Eligibility.shtml to learn more about eligibility and selection

criteria.

HIGHLIGHTED TB REPORTS

FROM APHA: Shut Down of US Government Over, but Effects Remain

POLITICO with APHA Executive Director Georges Benjamin — Shutdown’s science fallout could last for years

The government is reopening, but the shutdown’s effects will linger for scientists studying everything from

climate change to cancer. Antarctica-bound field researchers stuck in budget limbo over the past three weeks

fret that decades of data on penguins and ice sheets will end up with a glaring gap, undercutting their

documentation of global warming. Doctors operating federal-funded clinical studies on Alzheimer’s, cocaine

addiction and heart disease worry they’ve lost the trust of patients. Public health officials warn the country is

still “flying blind” for the start of the flu season. “Even if the government opens tomorrow, a significant

amount of damage has been done,” said Mary Woolley, president of Research!America, a nonprofit

advocating for science-minded agencies. “This isn’t about a few people who can’t go to the labs like they’re on

vacation or something. The whole research enterprise depends on operating 24/7.” Thinking more of the big

picture, there’s also the little matter of keeping the best and brightest researchers working in, and for, the

United States or seeing them flee to the private sector. It’s a realistic expectation after nearly three years of

stop-and-go budget battles resulting in sequestration and now the cruel reality of laboratories ordered to keep

the lights out. “Would you go work for someone where the funding is squishy?” said Georges Benjamin,

executive director at the American Public Health Association.

FROM RESULTS:

Two recent important articles on TB in children:

More Evidence to Support Screening of Child Contacts of Tuberculosis Cases: If Not Now, Then When?

High incidence of pulmonary tuberculosis in children admitted with severe pneumonia in Uganda

[Read: Screening of Child Contacts of Tuberculosis Cases]

[Read: Pulmonary TB]

Houston Chronicle Op-Ed by Dr. Jeffrey Starke. October 11, 2013

Road map for Childhood Tuberculosis

"... we need to create a sense of urgency beyond the TB community"

Landon is a 3-year-old boy who, two years ago, became fussy and had a seizure. He had drug-resistant

tuberculosis (TB) meningitis. After 21 months of taking difficult drugs and almost three months in the hospital,

he is doing surprisingly well.

Jon is a 16-year-old with diabetes who developed TB in his lungs that almost killed him. Several friends and

healthcare workers caught the germ from him.

These are not children in Africa or Asia. They are children in Texas.

Over the past 30 years, I have cared for 1,000 children with TB and am considered an expert regarding the

disease. The bad news is that I became an expert right here in Houston. Today, the tuberculosis clinic at Texas

Children’s Hospital is as busy as it ever has been. Tuberculosis remains one of the major global scourges of

humans. Every year, more than one million people around the world die from it. Well over 75,000 deaths are

in children. Children who breathe in TB germs can become ill within weeks or a few months. Children often do

not show signs of illness until the disease is advanced and difficult to treat. The true tragedy is that TB is both

curable and preventable if the available tools are applied properly.

Childhood TB has been neglected for many reasons. Children with TB are often poor and live in vulnerable

communities where there is poor access to health care. Making the diagnosis can be difficult, so TB is often

missed or overlooked. Most young children with TB are not contagious. As such they are ignored in places

where the disease is common among adults. And no one has been speaking out for children. Fortunately, the

tide is turning. On Oct. 1, in conjunction with the US Centers for Disease Control and Prevention and USAID,

the World Health Organization, the International Union Against Tuberculosis and Lung Disease and several

other organizations launched the Roadmap for Childhood Tuberculosis. This landmark document outlines the

10 essential steps that, if followed, will ensure that no child, from Houston to Hong Kong, dies from TB.

Achieving this goal requires sustained advocacy, greater commitment, mobilization of increased resources,

enhanced research and a joint effort by everyone involved in providing health care for children. Implementing

this roadmap requires better use of the available tools. It also will require research to develop better

diagnostic tests and child-friendly drugs. While much of this research will be done in Africa and Asia, Houston

also has a rich history of childhood TB research that dates back 65 years. Many of the techniques of modern

TB control were developed in Houston. Of course, all of this requires money, but not as much as you might

think. For $80 million a year for prevention and treatment, and $40 million for research, childhood TB can be

eliminated as one of the 10 leading causes of death in children.

However, money is not enough.

Two major actions are required. First, we need to create a sense of urgency beyond the TB community. Rather

than waiting for children to become seriously ill before we find and treat them, the broader child health

community must get involved to find and prevent childhood TB.

Second, we must include the needs of children in research and policy development. This will benefit both

adults and children. A large proportion of adults who develop TB actually acquired the infection when they

were children. The treatment of these children will prevent future cases of contagious adult TB and the cycle

of transmission will be broken.

The common wisdom among folks who care for children with TB is that every case is preventable, and is a

failure of TB control. We must ask ourselves how much longer we will allow this preventable disease to hurt

and kill children all over the world. It is too late to prevent the disease that Landon and Jon had to battle, but it

is not too late for millions of other kids just like them, here and around the world.

Jeffrey R. Starke, a physician, is a professor of pediatrics at Baylor College of Medicine and is one of the

authors of the Roadmap for Childhood Tuberculosis.

NEW RESOURCES

FROM MCN:

You now have access to the complete series of recorded webinars on Clinician Orientation to Migration Health

to view at your convenience! Each module is accredited for an hour of Continuing Nursing or Continuing

Medical Education. Complete all 7 modules and you will receive a Certificate of Expertise in Migration Health.

Click here to access this series and find out more information.

JOURNAL ARTICLES

(October 3 – October 17, 2013)

AIDS. 2013. Sep 25. [Epub ahead of print]

The effect of tuberculosis treatment on virologic and CD4+ cell count response to combination antiretroviral

therapy: a systematic review . SOETERS HM, Napravnik S, Patel MR, Eron JJ Jr, et al.

PubMed: www.amedeo.com/p2.php?id=24072197&s=tb&pm=2

AIDS. 2013;27:2577-2586.

Paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome after early initiation of

antiretroviral therapy in a randomized clinical trial . LAUREILLARD D, Marcy O, Madec Y, Chea S, et al.

PubMed: www.amedeo.com/p2.php?id=24096631&s=tb&pm=2

Am J Epidemiol. 2013 Oct 7. [Epub ahead of print]

Modeling the Impact of Alternative Strategies for Rapid Molecular Diagnosis of Tuberculosis in Southeast

Asia.Sun AY, Pai M, Salje H, Satyanarayana S, Deo S, Dowdy DW.

Am. J. Epidemiol. 2013 178: 1281-1288

Contribution of Seasonality in Transmission of Mycobacterium tuberculosis to Seasonality in Tuberculosis

Disease: A Simulation Study Lucia C. Soetens, Hendriek C. Boshuizen, and Hester Korthals Altes

http://aje.oxfordjournals.org/content/178/8/1281.abstract.html?etoc

Antimicrob Agents Chemother . 2013 Oct 7. [Epub ahead of print]

The Sensititre(R) MYCOTB MIC plate for susceptibility testing of Mycobacterium tuberculosis to 1st and 2nd

line drugs.Lee JS, Armstrong DT, Ssengooba W, Park JA, Yu Y, Mumbowa F, Namaganda C, Mboowa G,

Nakayita G, Armakovitch S, Chien G, Cho S, Via LE, Barry CE 3rd, Ellner JJ, Alland D, Dorman SE, Joloba ML.

Arch Gynecol Obstet. 2013 Oct 8. [Epub ahead of print]

Abdominopelvic tuberculosis mimicking advanced ovarian cancer and pelvic inflammatory disease: a series of

28 female cases.Liu Q, Zhang Q, Guan Q, Xu JF, Shi QL.

Asia Pac J Public Health . 2013 Oct 4. [Epub ahead of print]

Factors Causing Delay of Access to Tuberculosis Diagnosis Among New, Active Tuberculosis Patients: A

Prospective Cohort Study.Shu W, Chen W, Zhu S, Hou Y, Mei J, Bai L, Xu W, Zhou L, Nie S, Cheng S, Xu Y.

Stakeholder Perceptions of a Pharmacy-Initiated Tuberculosis Referral Program in Cambodia, 2005-2012.Bell

CA, Duncan GJ, Eang R, Saini B.

Comparison Between Peer-Led and Teacher-Led Education in Tuberculosis Prevention in Rural Middle Schools

in Chongqing, China.Liu Q, Liu L, Vu H, Liu X, Tang S, Wang H.

BMC Health Serv Res . 2013 Oct 8;13(1) [Epub ahead of print]

Healthcare provision for HIV co-infected tuberculosis patients in rural Zambia: an observational cohort study

at primary care centers.Miyano S, Muvuma S, Ishikawa N, Endo H, Msiska C, Syakantu G.

The role of AFB microscopy training in improving the performance of laboratory professionals: analysis of pre

and post training evaluation scores.Reji P, Aga G, Abebe G.

BMC Infect Dis . 2013 Oct 7;13(1) [Epub ahead of print]

Efficacy and safety of thrice weekly DOTS in tuberculosis patients with and without HIV co-infection: an

observational study.Vashishtha R, Mohan K, Singh B, Devarapu SK, Sreenivas V, Ranjan S, Gupta D, Sinha S,

Sharma SK.

Subcutaneous emphysema as the first relevant clinical sign of complicated tubercular lymph node disease in a

child.Esposito S, Giannini A, Biondetti P, Bonelli N, Nosotti M, Bosis S, Calderini E, Principi N.

Association between tuberculin skin test result and clinical presentation of tuberculosis disease.Auld SC, Click

ES, Heilig CM, Miramontes R, Cain KP, Bisson GP, Mac Kenzie WR.

Clin Infect Dis . 2013. Oct 10 [Epub ahead of print]

Contact Investigation for Active Tuberculosis among Child Contacts in Uganda . JAGANATH D, Zalwango S,

Okware B, Nsereko M, et al.

PubMed: www.amedeo.com/p2.php?id=24077055&s=tb&pm=2

Curr Infect Dis Rep . 2013 Oct 12. [Epub ahead of print]

Central Nervous System Tuberculosis: Challenges and Advances in Diagnosis and Treatment.Chin JH, Mateen

FJ.

Curr Opin HIV AIDS . 2013 Oct 4. [Epub ahead of print]

Pipeline of drugs for related diseases: tuberculosis.Dooley KE, Nuermberger EL, Diacon AH.

Epidemiol Infect. 2013 Oct 7:1-5. [Epub ahead of print]

Micronutrient supplementation and T cell-mediated immune responses in patients with tuberculosis in

Tanzania.Kawai K, Meydani SN, Urassa W, Wu D, Mugusi FM, Saathoff E, Bosch RJ, Villamor E, Spiegelman D,

Fawzi WW.

Epidemiol Infect. 2013 Oct 10:1-7. [Epub ahead of print]

PCR to detect Mycobacterium tuberculosis in respiratory tract samples: evaluation of clinical data.Rozales FP,

Machado AB, DE Paris F, Zavascki AP, Barth AL.

Eur Respir J. 2013 Oct 10. [Epub ahead of print]

Tuberculosis transmission between foreign and native-born in EU/EEA: a systematic review.Sandgren A,

Schepisi MS, Sotgiu G, Huitric E, Migliori GB, Manissero D, van der Werf MJ, Girardi E.

Expert Opin Drug Deliv. 2013 Oct 8. [Epub ahead of print]

State of the art and future directions in nanomedicine for tuberculosis.Dube A, Lemmer Y, Hayeshi R, Balogun

M, Labuschagne P, Swai H, Kalombo L.

Gastroenterol. 2013 Oct;51(10):1177-1183. Epub 2013 Oct 11.

Development of Miliary Tuberculosis under Infliximab in a Patient with Spondyloarthritis and Suspected

Crohn's Disease. Koschny R, Junghanss T, Mischnik A, Karner M, Kreuter M, Roth W, Stremmel W, Merle U.

Glob Health Action . 2013 Oct 3;6:21699. doi: 10.3402/gha.v6i0.21699.

Association between South African high-school learners' knowledge about tuberculosis and their intention to

seek healthcare.Naidoo S, Taylor M.

Hum Mol Genet . 2013 Oct 8. [Epub ahead of print]

Genome-wide association study of ancestry-specific TB risk in the South African Coloured population.Chimusa

ER, Zaitlen N, Daya M, Möller M, van Helden PD, Mulder NJ, Price AL, Hoal EG.

International Journal of Mycobacteriology , Available online 6 October 2013

Evaluation of the effectiveness of BACTEC MGIT 960 for the detection of mycobacteria in Bangladesh

Mehedi Hasan, Saurab Kishore Munshi, Mst.Sabiha Banu Momi, Farjana Rahman, Rashed Noor

IJTLD Volume 17, Number 11 - November 2013

TIMEBOMB revisited 10 years later: can we sustain progress or are we losing the war?

L. B. Reichman

Role of the QuantiFERON ®-TB Gold In-Tube test in the diagnosis of intrathoracic childhood tuberculosis R.

Lodha, A. Mukherjee, D. Saini, S. Saini, V. Singh, S. Singh, H. M. S. Grewal, S. K. Kabra, and the Delhi

TB Study Group

Risk factors for mortality in Malawian children with human immunodeficiency virus and tuberculosis co-

infectionW. C. Buck, D. Olson, M. M. Kabue, S. Ahmed, L. K. Nchama, A. Munthali, M. C. Hosseinipour, P. N.

Kazembe

Improving tuberculosis screening and isoniazid preventive therapy in an HIV clinic in Addis Ababa, EthiopiaS.

Zaeh, R. Kempker, E. Stenehjem, H. M. Blumberg, O. Temesgen, I. Ofotokun, A. Tenna

Integrating HIV testing and care into tuberculosis services in Benin: programmatic aspects

O. Ferroussier, R. A. Dlodlo, D. Capo-Chichi, F. Boillot, M. Gninafon, A. Trébucq, P. I. Fujiwara

Results of rapid and successful integration of HIV diagnosis and care into tuberculosis services in BeninO.

Ferroussier, R. A. Dlodlo, D. Capo-Chichi, F. Boillot, M. Gninafon, A. Trébucq, P. I. Fujiwara

Impact of HIV on clinical presentation and outcomes of tuberculosis treatment at primary care levelC.

Henegar, F. Behets, K. Vanden Driessche, M. Tabala, A. Van Rie

Tuberculosis among the homeless, United States, 1994–2010S. Bamrah, R. S. Yelk Woodruff, K. Powell, S.

Ghosh, J. S. Kammerer, M. B. Haddad

Risk factors for death among hospitalised tuberculosis patients in poor urban areas in Manila, The

PhilippinesT. Shimazaki, S. D. Marte, N. R. D. Saludar, E. M. Dimaano, E. P. Salva, K. Ariyoshi, J. B. Villarama,

M. Suzuki

Treatment outcomes of tuberculosis patients in Brazilian prisons: a polytomous regression analysisL. Ribeiro

Macedo, B. Reis-Santos, L. W. Riley, E. L. Maciel

Monitoring changes in anti-tuberculosis treatment: associated factors determined at the time of diagnosisM.

N. Altet, R. Vidal, C. Milá, T. Rodrigo, M. Casals, I. Mir, J. Ruiz-Manzano, M. A. Jiménez-Fuentes, F. Sánchez, J.

Maldonado, R. Blanquer, M. L. de Souza-Galväo, J. Solsona, E. Azlor, D. Díaz,

J. L. Calpe, J. A. Caylá

Pharmacokinetics and serum concentrations of antimycobacterial drugs in adult Turkish patients

A. Babalık, I. H. Ulus, N. Bakirci, T. Kuyucu, H. Arpag, L. Dagyildiz, E. Çarpaner

Comparison of time to positive and colony counting in an early bactericidal activity study of anti-tuberculosis

treatmentC. M. Bark, P. Gitta, S. Ogwang, M. Nsereko, B. A. Thiel,

W. H. Boom, K. D. Eisenach, M. L. Joloba, J. L. Johnson

Dose-response association between salivary cotinine levels and Mycobacterium tuberculosis infection

S. S. Shin, R. Laniado-Laborin, P. G. Moreno, T. E. Novotny, S. A. Strathdee, R. S. Garfein

Comparison of molecular and immunological methods for the rapid diagnosis of smear-negative tuberculosisC.

Jafari, M. Ernst, B. Kalsdorf, C. Lange

Similar seasonal peak in clustered and unique extra-pulmonary tuberculosis notifications: winter crowding

hypothesis ruled out?R. Top, H. Boshuizen, A. Dekkers, H. Korthals Altes

Contribution of CD14 -159C/T polymorphism to tuberculosis susceptibility: a meta-analysisJ. Zhao, G. Lin, W-H.

Zhang, M. Ge, Y. Zhang

Characterisation of Mycobacterium tuberculosis isolates lacking IS6110 in Viet NamM. N. T. Huyen, E. W.

Tiemersma, K. Kremer, P. de Haas, N. T. N. Lan, T. N. Buu, C. Sola, F. G. J. Cobelens, D. van Soolingen

Proficiency of drug susceptibility testing ofMycobacterium tuberculosis against pyrazinamide: the Swedish

experienceS. Hoffner, K. Ängeby, E. Sturegård, B. Jönsson, A. Johansson, M. Sellin, J. Werngren

First proficiency testing of second-line anti-tuberculosis drug susceptibility testing in 12 provinces of ChinaG-L.

Jiang, X. Chen, Y. Song, Y. Zhao, H. Huang, K. M. Kam

Changes in vitamin C and oxidative stress status during the treatment of tuberculous meningitisD. Miric, R.

Katanic, B. Miric, B. Kisic, N. Popovic,V. Nestorovic

Indoleamine 2,3-dioxygenase in the pathogenesis of tuberculous pleurisyY. Suzuki, S. Miwa, T. Akamatsu, M.

Suzuki, M. Fujie, Y. Nakamura, N. Inui, H. Hayakawa, K. Chida, T. Suda

Smoking and tuberculous infection: chasing associations with imperfect exposure and outcome measuresR. N.

van Zyl-Smit, M. Pai

Int J Pharm . 2013 Oct 15;455(1-2):169-81. doi: 10.1016/j.ijpharm.2013.07.043. Epub 2013 Jul 31.

Risk based approach for design and optimization of stomach specific delivery of rifampicin.Vora C, Patadia R,

Mittal K, Mashru R.

J Acquir Immune Defic Syndr. 2013 Oct 2. [Epub ahead of print]

Integration and task-shifting for TB/HIV care and treatment in highly resource-scarce settings: one size may

not fit all.Van Rie A, Patel MR, Nana M, Driessche KV, Tabala M, Yotebieng M, Behets F.

J Biosoc Sci . 2013 Oct 8:1-21. [Epub ahead of print]

LESSONS FROM HISTORY OF SOCIOECONOMIC IMPROVEMENTS: A NEW APPROACH TO TREATING MULTI-

DRUG-RESISTANT TUBERCULOSIS.Holloway KL, Staub K, Rühli F, Henneberg M.

J Clin Microbiol . 2013 Oct 2. [Epub ahead of print]

Qualitative analysis to ascertain the genotypic identity of or differences between Mycobacterium tuberculosis

isolates in laboratories with low resources.Sislema-Egas F, Ruiz-Serrano MJ, Bouza E, García-de-Viedma D.

J Clin Microbiol . 2013. Oct 9. [Epub ahead of print]

Exploring alternative biomaterials for diagnosis of pulmonary tuberculosis in HIV negative patients using the

Xpert MTB/RIF assay . SHENAI S, Amisano D, Ronacher K, Kriel M, et al.

PubMed: www.amedeo.com/p2.php?id=24108610&s=tb&pm=2

J Infect Dis . 2013 Oct 4. [Epub ahead of print]

Interleukin 22 Inhibits Intracellular Growth of Mycobacterium tuberculosis by Enhancing Calgranulin A

Expression.Dhiman R, Venkatasubramanian S, Paidipally P, Barnes PF, Tvinnereim A, Vankayalapati R.

J Infect Dis . 2013 Oct 10. [Epub ahead of print]

Ratio of Monocytes to Lymphocytes in Peripheral Blood Identifies Adults at Risk of Incident Tuberculosis

Among HIV-Infected Adults Initiating Antiretroviral Therapy.Naranbhai V, Hill AV, Abdool Karim SS, Naidoo K,

Abdool Karim Q, Warimwe GM, McShane H, Fletcher H.

Lancet . 2013 Oct 5;382(9899):1183-1194. doi: 10.1016/S0140-6736(13)61131-9. Epub 2013 Aug 1.

Effect of household and community interventions on the burden of tuberculosis in southern Africa: the

ZAMSTAR community-randomised trial.Ayles H, Muyoyeta M, Du Toit E, Schaap A, Floyd S, Simwinga M,

Shanaube K, Chishinga N, Bond V, Dunbar R, De Haas P, James A, van Pittius NC, Claassens M, Fielding K, Fenty

J, Sismanidis C, Hayes RJ, Beyers N, Godfrey-Faussett P; the ZAMSTAR team.

MMWR Morb Mortal Wkly Rep . 2013 Oct 4;62(39):805-809.

Transmission of Mycobacterium tuberculosis in a High School and School-Based Supervision of an Isoniazid-

Rifapentine Regimen for Preventing Tuberculosis - Colorado, 2011-2012.Centers for Disease Control and

Prevention (CDC).

Occup Med (Lond) 2013 63: 458-460

Occupational screening of health care workers for tuberculosis infection: tuberculin skin testing or

interferon-γ release assays?Madhukar Pai and Niaz Banaei

http://occmed.oxfordjournals.org/content/63/7/458.extract.html?etoc

Pediatr Infect Dis J . 2013 Oct 7. [Epub ahead of print]

Intracellular Cytokine and Cathelicidin Secretion from Monocytes and Neutrophils in Childhood

Tuberculosis.Torun E, Cakir E, Aktas EC, Gedik AH, Deniz G.

PLoS One. 2013 Oct 3;8(10)

The Contribution of Non-Conventional T Cells and NK Cells in the Mycobacterial-Specific IFNγ Response in

Bacille Calmette-Guérin (BCG)-Immunized Infants.Zufferey C, Germano S, Dutta B, Ritz N, Curtis N.

Systematic Review of the Performance of Rapid Rifampicin Resistance Testing for Drug-Resistant

Tuberculosis.Arentz M, Sorensen B, Horne DJ, Walson JL.

Tuberculosis in Healthcare Workers and Infection Control Measures at Primary Healthcare Facilities in South

Africa.Claassens MM, van Schalkwyk C, du Toit E, Roest E, Lombard CJ, Enarson DA, Beyers N, Borgdorff MW.

Extrapulmonary Tuberculosis: Mycobacterium tuberculosis Strains and Host Risk Factors in a Large Urban

Setting in Brazil.Gomes T, Vinhas SA, Reis-Santos B, Palaci M, Peres RL, Aguiar PP, Ribeiro FK, Marques HS,

Dettoni VD, Johnson JL, Riley LW, Maciel EL.

PLoS Comput Biol . 2013 Oct;9(10):e1003253. Epub 2013 Oct 3.

Target Prediction for an Open Access Set of Compounds Active against Mycobacterium tuberculosis.Martínez-

Jiménez F, Papadatos G, Yang L, Wallace IM, Kumar V, Pieper U, Sali A, Brown JR, Overington JP, Marti-Renom

MA.

Respir Med. 2013 Sep 22. pii: S0954-6111(13)00376.

Effects of the Health Transformation Programme on tuberculosis burden in Turkey . YILDIRIM Z, Turkkani

MH, Bozkurt H, Islek E, et al.

PubMed: www.amedeo.com/p2.php?id=24084061&s=tb&pm=2

Scand J Infect Dis. 2013 Oct 10. [Epub ahead of print]

Impact of cytotoxic and targeted antineoplastic drugs on the validity of the mitogen-induced interferon-

gamma release assay for latent tuberculosis infection: Results of a prospective trial at a comprehensive cancer

center.Rodriguez GH, Safdar A.

Sci Transl Med . 2013 Oct 2;5(205):205ra134 A Human Type 5 Adenovirus-Based Tuberculosis Vaccine Induces

Robust T Cell Responses in Humans Despite Preexisting Anti-Adenovirus Immunity.Smaill F, Jeyanathan M,

Smieja M, Medina MF, Thanthrige-Don N, Zganiacz A, Yin C, Heriazon A, Damjanovic D, Puri L, Hamid J, Xie F,

Foley R, Bramson J, Gauldie J, Xing Z.

Travel Medicine and Infectious Disease , Available online 8 October 2013

Flight related tuberculosis contact investigations in the United States: Comparative risk and economic analysis

of alternate protocols Karen J. Marienau, Elaine H. Cramer, Margaret S. Coleman, Nina Marano, Martin S.

Cetron

Trop Doct . 2013 Oct 4. [Epub ahead of print]

Initial combination of injectable and oral anti-tuberculosis agents for the treatment of severe disseminated

tuberculosis.Boff DF, Goldani LZ.

Trop Med Int Health . 2013 Oct 8. doi: 10.1111/tmi.12197.

Patient care pathways under the model of integrating tuberculosis service with general hospitals in China .

WEI X, Yin J, Zou G, Walley J, et al.

PubMed: www.amedeo.com/p2.php?id=24107010&s=tb&pm=2

Vaccine. 2013 Oct 10. [Epub ahead of print]

Family history of immigration from a tuberculosis endemic country and low family income are associated with

a higher BCG vaccination coverage in Ile-de-France region, France.Guthmann JP, Chauvin P, Le Strat Y, Soler M,

Fonteneau L, Lévy-Bruhl D.

FUNDING OPPORTUNITIES

From the Stop TB Partnership:

TB REACH, an initiative of the Stop TB Partnership that aims to increase the number of people with

tuberculosis (TB) who are found and provided with quality care, has launched a call for applications for its

fourth wave of funding. Partners of the Stop TB Partnership, national TB programmes, HIV programmes, local

and international nongovernmental organizations, civil society and community-based organizations can apply

for this fast-track funding which encourages the use of innovative approaches among poor, vulnerable and at-

risk populations.

Seventy-eight countries are eligible for wave four funding. Applicants can propose all types of innovative TB

case finding interventions, however they are encouraged to focus on detecting TB in the following

populations: mining-affected communities, migrants, children, incarcerated persons and indigenous

populations and ethnic minorities. TB REACH will prioritize funding for applicants who can provide co-funding

as well as those that propose scaling up interventions to a provincial or national level. There will be a separate

funding track limited to civil society and small domestic NGOs.

This funding will be limited in scope but will provide small organizations with a chance to access TB REACH

funds to support early and increased TB case detection and improved treatment outcomes in the communities

they serve. Due to overwhelming demand in previous waves, TB REACH has instituted a two-stage process to

review proposals. Applicants must first submit a letter of intent (LOI) to TB REACH that will be reviewed by the

Proposal Review Committee in December 2013.

Organizations that are shortlisted following the review of LOIs will be invited to submit a full application later

in December. Detailed information about wave four, the LOI, the proposal review process, eligible countries,

some of the different types of interventions that would be appropriate and other requirements for submission

are available on the Stop TB Partnership website . The deadline for submitting LOIs for Wave 4 is 8 November

2013.

COURSES/WORKSHOPS

FROM THE RTMCCs

THE SOUTHEAST NATIONAL TB CENTER (SNTC)

Motivational Interviewing: Guiding Positive Change in Patient Behaviors

Date: 11/6/2013 - 11/6/2013 Time: 1:00 PM - 2:30 PM Eastern Location: SNTC

Instructor/speaker: Ann Landes, PhD

Cost: No Charge

Format: Webinar

Providing caring and effective services for our patients with TB can be emotionally and psychologically

demanding. This is especially true as we reflect upon the link between a patient’s biopsychosocial well-being

and the choices they make which can directly impact their current and future health status. This interactive

webinar will focus on the critical issue of healthy decision-making and change, specifically through the

employment of an evidence-based practice: Motivational Interviewing (MI). Attendees of this webinar will be

introduced to the foundational concepts of MI, as well as the benefits of its employment; taught skills that

promote collaborative working relationships with the most challenging of patients; and provided tools that

guide patients toward more positive health behavior changes. The class is designed to encourage engaged

learning through the use of vignettes and real-time, online “knowledge checks”.

Comprehensive Clinical TB Course

Date: 12/9/2013 - 12/12/2013 Time: 8:00 AM - 5:00 PM Eastern

Location: SNTC Format: Clinical course

This four-day intensive course will familiarize the clinician with all the aspects of tuberculosis infection, disease

and clinical care using an interdisciplinary and interactive approach. The curriculum is provided through

lecture, interactive case management sessions. The faculty is selected for their unique skill in encouraging

interaction and building rapport with participants. The atmosphere is relaxed with an expectation that a free

exchange of questions, comments and information will occur.

Tuberculin Skin Test Train-the-Trainer Course

7 credit(s) Date: 12/13/2013 - 12/13/2013 Time: 8:00 AM - 5:00 PM Eastern

Location: SNTC Instructor/speaker: Ellen R Murray, BSN, RN Format: Lecture/didactic

This one-day skill-building course provides the knowledge needed to plan, teach, and evaluate a Mantoux

Tuberculin Skin Test (TST) course. The course content includes skills for planning and conducting a TST training,

including adult learning principles and teaching strategies. The curriculum is provided through lecture and

participatory activities, including practicum in TST administration and reading and instructional skills

demonstration.

Each participant must demonstrate proficiency in delivering course content plus administering and reading the

TST. Participants will receive feedback from experienced trainers as they practice their skills. Topics include:

adult learning principles for instructors, tips and tools to plan and conduct a successful TST training, and TST

course curriculum review and demonstration. Additional information: Agenda , Flyer

THE NEW JERSEY MEDICAL SCHOOL GLOBAL TB INSTITUTE

Upcoming Trainings:

TB Today-Integrating Knowledge with Practice November 14 Sturbridge, MA

The purpose of this training is to strengthen providers' knowledge of tuberculosis. Format will include lectures,

discussions and interactive breakout sessions. Please check back for additional information. Brochure Register

Medical Update #2: Pitfalls in the Diagnosis and Management of TB November 20 Web-based

This web-based seminar for physicians and nurses will cover atypical presentations of tuberculosis which may

complicate, and at times, delay the diagnosis and medical management of tuberculosis disease. Case

examples will be included to illustrate examples of challenges in diagnosis and management of complex TB

cases. In addition, speakers will share experiences on how to manage such cases using existing resources.

THE HEARTLAND TB CENTER

Course Schedule Click Here for Class Information

Contact Investigation Interviewing Skills Nov 19-22, 2013 Houston, TX

Visit the Event Page » apply »

Contact: jessica.quintero@uthct.edu Deadline November 1, 2013

THE CURRY INTERNATIONAL TUBERCULOSIS CENTER

The Curry International Tuberculosis Center is pleased to announce that our 2013 Training Schedule is now

available, please visit: http://www.currytbcenter.ucsf.edu/training/schedule_2013.cfm .

Tuberculosis Case Management and Contact Investigation Intensive Date: November 12-14, 2013

Location: Oakland, CA

The Curry International TB Center in Oakland is pleased to announce an upcoming tuberculosis (TB) case

management and contact investigation training which will be conducted in Oakland on November 12-14, 2013.

This 3-day course covers many aspects of TB case management and contact investigation, including current

contact investigation guidelines, managing the care of TB patients, promoting adherence to treatment, and

more. For a complete training description and application information, please visit:

http://www.currytbcenter.ucsf.edu/training/tbcmcinov13.cfm Application deadline is September 23 rd.

Nurse-to-Nurse Training Date: December 2013 Location: San Francisco, CA

Archived Webinar Now Available: The Affordable Care Act and Tuberculosis Control: Navigating New

Territory http://www.currytbcenter.ucsf.edu/training/webarchive/acatbc/arch_acatbc.cfm

This 90-minute webinar was created for public and private clinicians and allied health personnel who work

with tuberculosis (TB). It clarified key information that TB Programs need to know related to the

implementation of the Affordable Care Act (ACA). The webinar was presented live on August 23, 2013. Faculty

and Panelists: Christine Ho, MD, MPH, Medical Officer, CDC; Julie Higashi, MD, PhD, Tuberculosis Controller,

San Francisco Department of Public Health; Tom Donohoe, MBA, Principal Investigator/Director, UCLA Pacific

AIDS Education Training Center, University of California, Los Angeles; Lisa Chen, MD, Principal Investigator,

Curry International Tuberculosis Center, Professor of Medicine, Division of Pulmonary and Critical Care

Medicine, University of California, San Francisco; John Bernardo, MD, Professor of Medicine and Biochemistry,

Boston University School of Medicine, Tuberculosis Control Officer, Massachusetts Department of Public

Health; and Naomi Seiler, JD, Associate Research Professor, Department of Health Policy, George Washington

University School of Public Health and Health Services

FROM NATIONAL JEWISH MEDICAL AND RESEARCH CENTER

The 51st Annual Denver TB Course April 9-12, 2014 Denver, Colorado

The purpose of this course is to present this body of knowledge to general internists, public health workers,

infectious diseases and chest specialists, registered nurses, and other health care providers who will be

responsible for the management and care of patients with tuberculosis. For more information and to register,

please call 800.844.2305 or visit www.njhealth.org/TBCourseApril 9-12, 2014Register online for the April 9-12,

2014 session or call 800.844.2305

FROM THE UNION

The Union’s International Management Development Programme 2013 Courses : To register for any of these

courses, visit www.union-imdp.org or email imdp@theunion.org to receive more information. Course fee for

all courses includes lodging, breakfast, lunch, coffee and tea breaks, and course materials.

MEETINGS & CONFERENCES

Alphabetically listed by sponsoring organization

AMERICAN PUBLIC HEALTH ASSOCIATION (APHA): 141st APHA Annual Meeting: November 2 - November 6,

2013, Boston, Ma

The APHA 141st Annual Meeting and Exposition will take place November 2–6 in Boston. Registration and

housing for the Annual Meeting opened June 3. Discounted registration fees will be available until August 22.

Opening General Session speakers include attorney and spokesperson on leadership and public issues, Sarah

Weddington, internationally acclaimed epidemiologist, Michael Marmot, and Boston Mayor, Thomas

Menino.

The Closing General Session will focus on the health of native people. Keynote speaker Evan Tlesla Adams will

share his experience as British Columbia’s first-ever aboriginal health physician advisor. The meeting will

include more than 1,000 scientific sessions and countless networking opportunities. Find more information

and register for the APHA Annual Meeting and Expo

THE UNION:

44th World Conference on Lung Health: October 30 - November 3, 2013,Paris, France

The 2013 theme is "Shared air, safe air?" Paris 2013 - Download Brochure The 44th Union World Conference

on Lung Health is a 5 day conference covering the latest developments, opportunities and challenges in

tuberculosis, HIV, tobacco control, lung health and non-communicable diseases. Registration can be accessed

from the website at www.worldlunghealth.org .

Through a collective effort, we have developed a roadmap of meetings, workshops and other events organized

by partners during and before the World Conference on Lung Health in Paris.

The roadmap is available on the Stop TB Partnership website.

For more information, consult the registration guidelines and the registration fees . When registering, do not

forget to select from the list your workshop or postgraduate course preference. Registration for these sessions

is on a first come, first-served basis. The full list of workshops and post-graduate courses is accessible from the

Programme menu on the website.

The abstract scientific programme is now available on the website! 940 abstracts have been accepted for

presentation at the 44th Union World Conference on Lung Health. These abstracts have been allocated into 67

Poster Discussion sessions and 27 Oral presentation sessions. The Oral abstract sessions and Poster discussion

sessions , which will take place on 1 - 2 - 3 November 2013, are now available for viewing on the website.

SAVE THE DATE! New opportunities for funding and engagement – Your role in the future of the Stop TB

Partnership Thursday 31st October, 11am – 5pm (10.30am coffee and registration) Hotel Le Meridien Etoile,

Paris (opposite the conference center) Conference registration is not required to attend

Following the approval of the Stop TB Partnership Secretariat’s Operational Strategy 2013-2015 and a series

of governance reforms, the Stop TB Partnership has recently undergone a period of change and evolution. This

meeting, which is open to all people visiting Paris for the World Conference on Lung Health, presents a unique

opportunity to discuss Secretariat priorities, governance reform and resources and funding opportunities.

The meeting is open to all those in Paris for the World Conference on Lung Health. Conference passes are not

required to attend this meeting. RSVP: Please send an email to stoptbpartnerships@stoptb.who.int including

your name, job title and organization.

Advocacy Corner: We are excited to share news of Advocacy Corner at this year’s Union World Conference on

Lung Health, held from 30 th October - 3 rd November, Paris, France. A popular space for exchanging

knowledge and networking at past conferences, this year’s Advocacy Corner will be hosted by the Stop TB

Partnership and Action at the Stop TB Partnership booth. We hope this space will be a place for advocates,

researchers, implementers, community members, and decision-makers to discuss, strategize, and learn more

about advocacy, and we plan to have an exciting programme of sessions running from 31 October to 3

November. If you have any questions about the Advocacy Corner, feel free to email Mandy

(mslutsker@results.org ) or Simon Logan (Logans@who.int ).

Book your hotel now! The Union has appointed Congrex Travel to deal with all accommodation requests for

The Union World Conference, offering a secure and uncomplicated hotel booking procedure. An easy online

reservation system makes attendance to the conference efficient and stress-free. Pre-negotiated hotel rates in

various price categories have been reserved exclusively for delegates attending the conference, suiting all

budgets. Please click here to see the full list of available hotels to select from, with detailed descriptions and

access plans. For further information on booking your hotel room in the heart of Paris please click here .

From TAG:

Cascades:Improving TB Care, Friday, November 1, 2013, 18h00 - 22h00 Location: Hôtel Concorde La Fayette

Batignolles/ Longchamp Room 3, Place du Général Koenig 75850 Paris Cedex 17 – France (within walking

distance of Le Palais des Congrès de Paris)

Conference registration NOT required for attendance. Refreshments and snacks will be served. For more

information: Lindsay.Mckenna@treatmentactiongroup.org

THE UNION, NORTH AMERICAN REGION:

18th Annual Conference of The Union, North America Region , February 27 – March 1, 2014, Boston, MA

Stronger Together: Stopping TB, From Laboratory to Clinic

REGISTRATION COMING SOON! For questions, please contact: Menn Biagtan at biagtan@bc.lung.ca

StopTBUSA was formerly known as the U.S. National Coalition for Elimination of Tuberculosis (NCET). Please

pass this information on to your colleagues who are interested in TB elimination.

©2013 StopTBUSA