NUTRIOSE® A source of long lasting energy

NUTRIOSE®

A source of long lasting

energy

Sophie Chesnoy

February 2013

2

Agenda

Diabetes education & prevention

Carbohydrates & glycaemia

NUTRIOSE®, a soluble dietary fiber

NUTRIOSE®, a soluble dietary fiber, which has low

glycaemic and insulinaemic responses

NUTRIOSE® is slowly fermented in the colon and

produces SCFA contributing to the daily energy supply

How to empower the general public on better

awareness?

3

Agenda









awareness?

4

World diabetes day 2012

Type 2 diabetes is a common and serious global health

problem, which, for most countries, has developed

together with rapid cultural and social changes, ageing

populations, increasing urbanisation, dietary changes,

reduced physical activity, and other unhealthy

behaviours.

There is conclusive evidence that type 2 diabetes can be

prevented through nutrition counselling, increasing

physical activity and modest weight reduction.

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Doak et al. Obes Rev 2012

Obesity in European women, self-reported 2001-2005.

Obesity in Europe

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Glycaemic Response: a market demand

1. N

utr

aceutical W

orld, o

cto

bre

2012 -

2. In

tern

ational D

iabete

s F

oundation

The market for the glycaemic response represents an opportunity

� 180 000 studies in 2012

Diabetic people

�366 millions of people worldwide2

A lot of people are not aware of risk associated

�Overweight & metabolic syndrome

�116 milliards dollars = USA annual cost for

patients care

« TREATMENT »« TREATMENT » « PREVENTION »« PREVENTION »

The glycaemic Response emerges as a solution:

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Lifestyle prevention

- RCT

- 523 subjects with impaired glucose levels

- Mean duration of follow-up: 3.2 years

Goals:

- Weight reduction

- Total fat intake

- Saturated fat

- Fiber

- Moderate exercise

Tuomilehto, NEJM 2001

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58% reduction in diabetes

3 kg weight loss

Tuomilehto, NEJM 2001

Prevention of type 2 diabetes by

lifestyle prevention

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Agenda









awareness?

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How to take advantage of these benefits?

Glycaemic index

Carbs

(Starch,Sugars,Fibers)

Variation of blood glycaemia &

energy supply

Management of

daily intake &

satiety

Long term consequences

(metabolic

syndrome)

The glycaemic response Energy balanceImpact on health

costs

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A number of factors influence glycaemic responses to food :

� Amount of carbs

� Type of sugar (glucose, fructose, sucrose lactose)

� Cooking & food processing

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Types of carbohydrates and energy

Complex fermentable carbohydrates are sometimes described as potentially good sources of long-lasting energybecause of a low GR, and because of providing "prolonged energy release".

A high and fast energy supply is often needed at the beginning of physical effort or for a short task.

A prolonged supply of energy over time is required, for example, during prolonged, endurance tasks, providing energy for brain (concentration, learning) and muscular effort:

- in the upper intestinal tract under a glucose form

- in the lower tract under SCFAs form

� Interest of NUTRIOSE® for prolonged energy release : a tool for reformulation

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Agenda









awareness?

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NUTRIOSE®

Provide some rapidly available energy for brain and

effort in the upper intestinal tract under a glucose form

(NUTRIOSE® 06 has a not nil energetical value ), while

inducing low glycaemic (GR = 25) and insulinaemic

responses (IR = 13)

Provide late energy converted from SCFAs, during further

digestion in the lower intestinal tract, to ketone bodies or

glucose, or directly used by muscles, due to bacterial

fermentations (prebiotic effect)

Maintain well-being during digestion (high digestive

tolerance threshold)

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Agenda









awareness?

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NUTRIOSE® 06

10 %

excreted

75 %

progressively

fermented

15 %

absorbed

Small intestine

Colon

Short chain

fatty acids

Biomass

Energy CO2

CH4/H2

Faeces

GlucoseUp

pe

r tr

act

Low

er

tra

ctWhat is Nutriose® ? Metabolic fate

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NUTRIOSE® : focus on glycaemic response -

the small intestine stage

Glycaemic and insulinaemic

responses after ingestion of

NUTRIOSE® compared to

dextrose : NUTRIOSE® has a low

GR and a low IR

low GR 25

low IR 13

Donazzolo et al., Dietary Fiber, 2003

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Agenda









awareness?

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NUTRIOSE® : focus on delayed energy

release – the large intestine stage

According to the definition of Woods and Gorbach (2001),

NUTRIOSE® 06 acts as a prebiotic fiber from 8 g/day:

� beneficial bacteria (glucidolytic flora ) and/or � in harmful bacteria

(proteolytic flora)

� intestinal pH

bacterial enzymes concentrations : � fecal α- and β-glucosidases

Slow and long-lasting colonic fermentations : SCFAs production, breath

hydrogen excretionLefranc-Millot C et al., chapters in books 2010, 2009

Lefranc-Millot C et al., Nutrition Bulletin, 2008

Van den Heuvel EGHM et al., Eur.J. Nutr., 2005

Van den Heuvel et al., Eur.J. Clin. Nutr., 2004

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Butyrate in particular, and other SCFAs, may promote satiety

Butyrate increases expression of gene encoding for PYY and GLP1

The pattern of fermentation (mostly the ratio acetate : propionate),

may impact the potential lipid lowering properties of non digestible

carbohydrates: colonic propionate is a gluconeogenic substrate in

humans and inhibits the use of acetate for cholesterol synthesis.

Partially

hydrolysed

guar gum

NUTRIOSE®

Inulin

Role of SCFAs

Stewart ML et al. Gastroenterology, 2007

Hamer, H. M et al. Aliment Pharmacol Ther, 2008

Zhou J et al.Obesity 2006

Hijova E et al. Bratisl Lek Listy, 2007

Wolever TMSet al. Am J Clin Nutr 199l

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TimeSmall Intestine Colon

Energy

GLUCOSE

(low GR)

SHORT CHAIN

FATTY ACIDS

+

= 2 kcal/g

NUTRIOSE® is a source of long-lasting energy

glucose

NUTRIOSE®

What is NUTRIOSE® ?

Metabolic fate

Livesey G, Nutrition Research Review, 1992

European Commission (2008) Commission Directive

2008/100/EC of 28 October 2008 amending Council Directive

90/496/EEC on nutrition labelling for foodstuffs as regards

recommended daily allowances, energy conversion factors and

definitions. Official Journal of the European Union L 285/9.

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Agenda









awareness?

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How to educate ?

Glycaemic indexCarbohydrates

Blood variation of glycaemia

impacting the

energy supply

Management of

daily caloric intake

Long term consequences,

metabolic syndrome

Glycaemic response

To increase people awareness about

this connection

Long terms consequences

New product positioning New promotion tools

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Age makes a difference

Younger

people

Younger

people

They find it harder to manage food habits,

especially female students and young people starting their career, who tend to

snack.

They realise how important

healthy food is when they have children.

They exercise more often to

manage their weight better.

Their nutritional knowledge is under average.

Not very interested in managing daily

caloric intake

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Age makes a difference

Older

people

Older

people

They are more concerned about food because they have more knowledge on the subject thank to their

experience.

Their lifestyle is more tranquil, they are more

serene

They are generally more concerned with their

weight / figure.

They are more concerned with food quality.

More concerned about finding

healthy food

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Conclusion

� NUTRIOSE® can be used at

the recommended dosage

for :

� fiber fortification

� prebiotic effects

� satiety and weight

management

A source of carbohydrate� decreased glycaemic response

� Prolonged energy supply

� …

CARBOHYDRATESFIBER

+

Healthy food choice for prediabetes people

NUTRIOSE® may be used in accordance with many of the WHO/FAO nutritional

recommendations (less sugars, more fibres, etc)

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THANK YOU

NUTRIOSE® A source of long lasting energy

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