NUTRIENTS AS BIOLOGICAL RESPONSE...
Transcript of NUTRIENTS AS BIOLOGICAL RESPONSE...
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NUTRIENTS AS BIOLOGICAL RESPONSE MODIFIERS changing the way the body works to reverse cancer
IMMUNE REGULATORS, ELIMINATE INFECTIONS?
ALTER GENETIC EXPRESSION OF CANCER
CELL MEMBRANE DYNAMICS
DETOXIFICATION
PH MAINTENANCE, BALANCING PROTONS
PROOXIDANTS & AOX, BALANCING ELECTRONS
CELLULAR COMMUNICATIONS (signal cell transduction)
PROSTAGLANDIN REGULATION
STEROID HORMONE CONTROL
ENERGY METABOLISM: AEROBIC VS ANAEROBIC
PROBIOTICS VS DYSBIOSIS
ANTI-PROLIFERATIVE AGENTS
ALTER TUMOR PROTECTIVE MECHANISMS
APOPTOSIS, PROGRAMMED CELL DEATH
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Change the rate of a reaction by: temperature
pH
surface area
concentration of substrates or enzymes
X y
enzyme niacin B-3
NAD
Recommended Dietary Allowances (RDA)"... do not cover
special nutritional needs arising from chronic diseases, and
drug therapies." National Research Council 1989
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CAN INDOLE-3-CARBINOL (I3C) REVERSE
CERVICAL INTRAEPITHELIAL NEOPLASIA (CIN)?
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200 MG 400 MG PLCB
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STUDY DESIGN: 30 women biopsy proven
CIN stage 2,3 given 200,
400 mg/day I3C or placebo
12 wk. CR in I3C
No toxicity observed.
Dose dependent response
Shifting 16 @hydroxyestrone
To 2 hydroxyestrone
Most HPV positive
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health
metastatic
malignancy
anaplasia
metaplasia
dysplasia
death
DNA
repair
apoptosis
NK attack
anti-angiogenesis
tumor encapsulation
CAN NUTRIENTS REVERSE THE CANCER PROCESS?
INITIATION
PROMOTION
PROGRESSION
I-3-C reverses CIN
folate reverses bronchial metaplasia & cervical dysplasia
vitamin A and beta-carotene reverse oral leukoplakia
calcium reverses colon crypts/polyps
vitamin E reverses fibrocystic breast disease
neoplasia
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HOW CAN NUTRIENTS AFFECT THE CANCER PROCESS?
Shklar, G., Alternative & Complementary Therapies, vol.2, no.3, p.156, May 1996
-inhibit angiogenesis
-dysregulate mutant p53 oncogene
-alter immune cytokines
Schwartz, JL, Cancer Prevention Intl., vol.3, p.37, 1997
-upregulate DNA repair
-augment programmed cell death (apoptosis)
Prasad, KN, et al., Arch.Otolaryngol.Head Neck Surg., vol.119, p.1133, Oct.1993
-regulate gene expression
-induce growth inhibition in cancer
-alter cell differentiation
Lupulescu, A., Intl.J.Vit.Nutr.Res., vol.63, p.3, 1993
-A, C, E regulators of cell differentiation, membrane biogenesis, DNA synthesis
-A, C, E may be cytotoxic and cytostatic in certain cell system
-affect oncogenes
Poppel, GV, et al., Cancer Letters, vol.114, p.195, 1997
-immune stimulation
-enhancement of cell to cell communication, defuse carcinogens, etc.
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CAN THERAPEUTIC NUTRITION
LOWER TUMOR RECURRENCE?
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RDA suppl. hi dose nutr
10 mo.actual
5 yr projected
% of bladder cancer patients with tumor recurrence source: Lamm, DL, J.Urol.,151, 21, Jan.1994
Study design: 65 patients w.
transitional cell carcinoma of
bladder, BCG immune tx,
randomized to either RDA
supplement 24 of 30 with
tumor recurrence) or RDA +
40,000 iu A, 100 mg B-6,
2 gm C, 400 iu E, 90 mg Zn
with 14 of 35 recurrence.
Hi dose nutrients cut tumor
recurrence in half.
-50%
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CAN FISH OIL IMPROVE OUTCOME
IN CANCER TREATMENT?
anti-cachectic: prevents & reverses wasting syndrome Ross, JA, Curr.Opin.Coin.Nutr.Metab.Care, vol.2, no.3, p.219, May 1999
induces apoptosis in cancer cells Hardman, WE, J.Nutr., vol.132, no.11 suppl, p.3508S, Nov.2002
upregulates immune function Kelley, DS, Nutrition, vol.17, no.7, p.669, Jul 2001
reduces stickiness of cells to slow metastasis
competes with omega-6 arachidonic acid metabolites Woutersen, RA, Mutat.Res., vol.443, no.1, p.111, Jul.1999
improves insulin sensitivity, lowers blood glucose
impairs tumor angiogenesis Rose, DP, Nutr.Cancer, vol.37, no.2, p.119, 2000
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DOES FISH OIL SUPPLEMENTATION AS SOLE THERAPY
IMPROVE OUTCOME IN PATIENTS WITH SOLID TUMORS?
“Omega 3 prolonged survival of all patients…resulted in significant
(p
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CAN NUTRIENTS EXTEND LIFESPAN IN
POST-SURGICAL (NSC) LUNG CANCER PATIENTS
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VITAMIN
USERS
NON-VIT
USERS
MEDIANSURVIVALMONTHS
STUDY DESIGN:
36 post-operative
NSC lung ca ptns
evaluated: diet hist,
supplement usage,
serum folate charted;
Exclusion: 2/d),folate
antagonists.
RESULTS: "Patients (19)
took vitamin supplements
more likely to be long
term survivors." p=.002
Source: Jatoi, A, et al., J.Surg.Oncol., vol.68, no.4, p.231, 1998
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FAT CHO
APPLIED HUMAN
CLINICAL NUTRITION
OXYGEN WATER
PROT FIBER
VITAMINS MINERALS
MDC CEN minor dietary
constituents conditionally essential
nutrients
QUASI-VIT
OTHERS
SURVIVING
THRIVING
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QuickTime™ and aDV/DVCPRO - NTSC decompressor
are needed to see this picture.
Nature to be commanded must be obeyed.
Sir Francis Bacon (1561-1626)
founder of scientific inquiry
Florida State University fsu.edu
"Look deep into nature and then you will understand
everything better." Albert Einstein
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MOST POPULAR GROCERY ITEMS IN AMERICA
1. Marlboro cigarettes
2. Coke Classic
3. Pepsi Cola
4. Kraft processed cheese
5. Diet Coke
6. Campbell’s soup
7. Budweiser beer
8. Tide detergent
9. Folger’s coffee
10. Winston cigarettes
from “1992 Top Ten Almanac”
by Michael Robbins
TOP 3 VEGGIES IN AMERICA:
CATSUP, FRENCH FRIES, ONION RINGS
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% OF AMERICANS NOT EATING THE RDA
Recommended Dietary Allowance=92%
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A B-1 B-2 B-3 B-6 B-12 C Ca Fe Mg
% below RDA
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Paleolithic vs. Modern Diet
% kcal protein
% kcal sucrose
% kcal fat
% PUFA in fat
PUFA/sat. ratio
Fiber gm/day
Sodium mg/day
Calcium mg/day
Vit. C mg/day
Source: Paleolithic Prescription by Eaton, Shostak, Konner, Harper & Row, 1988
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Beef 2
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~6900
740
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Grouse 60 1.41
100+
690
1500+
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Modern U.S. Diet Paleolithic Diet
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SAN DIEGO WILD ANIMAL PARK
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NUTRIENT INTAKE IS CRUCIAL FOR ALL PLANTS
AND ANIMALS ON EARTH
but not for humans?
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Can a healthy lifestyle lower overall mortality? Hale Project: 1507 healthy men + 832 women, ages 70-90, 11 countries
Europe, 12 year followup (1988-2000), adherence to Mediterranean diet,
exercise, no smoking, moderate alcohol
Conclusions: "adherence to a Mediterranean diet and healthful lifestyle is
associated with a more than 50% lower rate of all-causes mortality." (95%CI)
Knoops, KT, JAMA, 2004;292:1433-9
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REASONS FOR OMNIVOROUS DIET
CARNIVORE NUTRIENTS
conjugated linoleic acid (CLA)
eicosapentaenoic acid (EPA)
cartilage (glycosaminoglycans)
carnitine
CoQ
B-12
zinc
quarternary amino acid sequence
biological value of protein
HERBIVORE nutrients
carotenoids (lycopene 800+)
bioflavonoids (quercetin 20,000)
anthocyanins (red in fruit/veg)
allylic sulfides (garlic, onion)
fucoidans (seaweed)
sterolins (beta sitosterol)
piperine (black pepper)
capsicum (red pepper)
fiber (butyrate)
lignans (flax, wh.grains)
potassium
anti-fungals (veg., mushr.,kelp)
chlorophyll
phytic acid (IP6, wh.grains)
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veg-e-tar-i-an (n.)
1. One who practices vegetarianism.
2. A herbivore.
3. Native American phrase "bad hunter"
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LOOKING AT A HEALTHY MEAL PLATE
tomato,spinach,carrot,peppers,
fruit,broccoli,cabbage,onion,etc
oatmeal,beans,bread,tortilla
pasta,yams,nuts,grains,
legumes,cooked vegetables
fish, wild game, poultry,
lean beef,eggs,br.yeast
beans, dairy,spirulina,kelp
1/3 1/3
1/3
raw fr/veg lo fat/hi pro
cooked whole plant food
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ORAC: OXYGEN RADICAL
ABSORBENCE CAPACITY
sponges for free radicals ORAC/5 GM
prunes 288
raisins 141
blueberries 111
blackberries 101
garlic 96
kale 88
cranberries 87
strawberries 76
spinach raw 60
plum 47
"...reduce risk of diseases of aging
by adding high ORAC foods to diet."
Floyd Horn, PhD, Tufts Univ.
need 3000-5000 ORAC units/day
(food & supplements)
average US intake 1200 ORAC
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NUTRITIONAL DEFICIENCIES time required to develop condition
O2 H2O C A
days
Ca Cr/E EPA,CoQ
et al.
0.003 2
30
180
14,600 14,600
16,425
?
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ADAPTIVE FORCES OF NATURAL SELECTION
(AFONS) FROM TOXIC TO ESSENTIAL
reaction
from
organism
time (eons)
toxic tolerated
essential
oxygen
sunlight
gut flora
selenium
blood sugar
iron
iodine
indole 3 car
quercetin
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WINDOW OF EFFICACY “First, do no harm.”
TOO MUCH CAN BE TOXIC
TOO LITTLE CAN BE INEFFECTIVE
DRUGS IRON VIT A
calcium
magnes
SELENIUM VIT C
B VIT
The difference between a medicine and a poison is dosage.
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ANNUAL CAUSES OF DEATH IN AMERICA CDC, Nat.Ctr Health Stat, JAMA, Consumer Prod.Safety Comm.
400,000 Tobacco
125,000 Alcohol
140,000 RX drugs
42,000 Auto accidents
36,000 Flu
9100 Food contamination
3300 Aspirin, bleeding
1064 Boating accidents
800 Bicycles
32 Skiing accidents
17 Hair dryers
15 Power lawn mower
4 Vending machine crushing
0 All vitamin supplements
1? Commercial herb products, mahuang
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source:Willner, C, Alt.Ther.,
10,4, 26, July 2004:
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Michelle Moore
Diagnosed May 2000
terminal kidney (renal) cancer
given 2 months to live
Alive and well as of Jan.2003
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CAN GAMMA LINOLENIC ACID IMPROVE OUTCOME
IN BREAST CANCER TREATMENT? Kenny, FS, et al., Int.J.Cancer, vol.85, p.643, 2000
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COMPL
RESP
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RESP
STAT DIS PROGR
DIS
TAMOXIFEN TAM + GLA
STUDY DESIGN: 47 elderly endocrine sensitive
br.ca. patients received
tamoxifen as 1st line tx
(controls) compared to 38
matched patients receiving
tamoxifen (20 mg od) +
gamma linolenic acid 2.8 g/d.
No drop outs & no side
effects in 42% exper. group.
Results at 6 mo. after
beginning tx.
"Phase 2 study suggests high
dose oral GLA to be a
valuable new agent in tx
ER/PR br.ca."
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DOES DIETARY FLAXSEED INFLUENCE
METASTASIS OF MELANOMA IN MICE?
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#TUMORS/MOUSE
CONTROL DIET 2.5% flaxseed
5% flaxseed 10% flaxseed
Lin, Y., et al., Cancer Letters, vol.124, p.181, 1998
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Synergism of Chemopreventive Nutrients
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Study design: female rats (15-30/group) exposed to 30 mg total DMBA begin at day 50 after birth, provided nutrient supplements from d 40-240; Rao, AR, et al, Jpn J Ca Res, vol 81, p 1239, Dec 1990
DMBA Se Mg C A Se+A Mg+C Mg+C +A
C+A+ Se+Mg
C+A +Se
C+A
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1 nutrient
2 nutrients
3 nutrients
4 nutr
% Animals with Tumors
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DOES NUTRITION IMPROVE OUTCOME?
over 900 trees planted (5 year survivor)
75% of our patients are refractory...failed therapy
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NUTRITION SUPPLEMENTS AGAINST CANCER
return on investment: risk/benefit/cost ratio
CORE: broad spectrum vit/min
extra C: 1-12 grams, buffered
extra E: 400 iu mixed
400 iu succinate
cod liver oil: 1 T/d, 20 caps
green tea
curcumin
BONUS: tolerate,afford? CLA, GLA
enzymes
thymus extract
bovine cartilage
garlic
probiotics
lipoic acid
CoQ
curcumin
silymarin
Maitake D-fraction
alkylglycerol (shark oil)
green tea
DISEASE-SPECIFIC prostate: lycopene
breast: cal-d-glucarate
colon: anti-fungal
lung: CoQ, vit.A
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ADJUVANT NUTRITION IN
CANCER TREATMENT BASIC diet: whole foods. omniv
-perimeter store
-perishable/sprout
-little or no label
-1/3 plate guide
protein (60-100 gm/d)
low glycemic/no sugar
no trans fats
high color vegetable*/fruit
supplements
-multi vit/min
-fish oil cap
-vit. C 1 gm/d
-AOX multiple
ADVANCED detect underlying cause of
failed homeostatic mech.
detect food allergies
supplements:
1-3 tsp fish oil
GLA
CLA
vit.D (2000-5000 iu)
green tea
CoQ
selenium
IP6
curcumin (curry)
fucoidan (seaweed)
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HERBAL MEDICINE AS SUPPLEMENTS:
echinacea
astragalus
Cat’s claw
Pau D’arco
ginseng
grape seed extract
aloe vera
red clover
milk thistle
Essiac
Hoxsey
Flor-Essence
AS SEASONINGS:
garlic
onion
hot peppers
cinnamon
ginger
real licorice
turmeric (curry)
parsley
sage
chicory
thyme
basil
AS FOODS:
soy
green & orange
dandelion greens
citrus
tomato
green tea
broccoli/cabbage
beets
sprouts
flaxseed meal
sesame seeds
Maitake mushrm
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HEALTHY SEASONINGS: HERBAL MEDICINE?
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COMPREHENSIVE CANCER
TREATMENT INCLUDES:
change underlying
cause(s) of disease
NUTRITION
DETOXIFICATION
DYSBIOSIS
HORMONE BAL.
HYPERGLYCEMIA
INFECTIONS
STRESS
EXERCISE
ENERGY PATHWAYS
ETC.
restrained tumor
debulking
CHEMO?
RADIATION
SURGERY
BURZYNSKI
HYPERTHERM
PHOTO-CYTO
HERBALS
APHERESIS
LYMPH.INFUS.
symptom
management
PAIN**
NAUSEA
ANOREXIA
ANEMIA
LEUKOPENIA
DEPRESSION
CACHEXIA
HAIR LOSS
1 2 3
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COMPLETE HOST DEFENSE MECHANISMS
person's life force
METAPHYSICAL
protection: spirit, love,
purpose, expression,
social network, touching
PHYSICAL protection:
nutrition, avoid toxins,
exercise, sun, fresh air,
body alignment
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BOB HOPE 100 YR
GEORGE BURNS 99 YR
MILTON BERLE 93 YR
WHAT DO THESE "LONGEVITY EXPERTS"
HAVE IN COMMON?
Art Linkletter 1912-? 93 yr
Groucho Marx 87 yr
Jack LaLanne 1915-? 91 yr
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STRESS AND DISEASE what you are eating may not be as important as what's eating you
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STRESS AND DISEASE what you are eating may not be as important as what's eating you
-Selye and General Adaptation Syndrome
atrophied thymus, erosion of gastric mucosa, elevated serum lipids
-Krebiozen cancer drug
-Cousins "galloping heart"
-placebo effect, sometimes equal to active drug
-sympathetic (fight or flight) vs parasympathetic nervous sys.
-ACTH alters other hormone pathways, growth, thyroid, etc.
-relaxation proven to help many ailments: physical & mental
-live life at your own pace
-lean on a "Higher Power"
-rest often
-Galen Clark story
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DETOXIFICATION TOXINS: lower immune functions & damage DNA
BODY POOL OF
TOXINS
AIR 50 million breathe polluted air
FOOD 1.2 bil. lb. pest. 4 mil. lb. antibiotic 2800 FDA additives
WATER 40% fresh water unusable 1300 pollutants in typical drink. OTHER
Hg amalgam EMF
URINE water, C, beans, chelation
FECES fiber, fluid psyllium, sena, probiotic
SWEAT skin largest organ exer, hot tub fever, jacuzzi
LIVER garlic, silymarin, Se & E, glutathione
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CHEMICAL RELEASES IN THE US
scorecard.org
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HAZARDOUS AIR POLLUTANTS CANCER RISK
scorecard.org
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SMOG AND PARTICULATE EMISSIONS IN US
scorecard.org
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EPA SUPERFUND CLEANUP SITES IN US
scorecard.org
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GALEN CLARK 1814-1910
"I went to the mountains to take my chances of dying or getting
better; which I thought were about even."
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BEATING
CANCER
WITH
NUTRITION 4th edition 2005
By Patrick Quillin, PhD,RD,CNS
NutritionCancer.com
Harnessing the incredible healing power of
nature and science for medically-treated
cancer patients.