Slide 1

NOVEL ELECTROSPUN NANOFIBERS IN DRUG DELIVERYPresented by :Venkatesh . YRegd no. 104Q1R0033,III / I B.Pharmacy,Narayana Pharmacy College, Nellore.GUIDE :SK. Raziya Begum,Assistant Professor,Dept of Pharmaceutics,Narayana Pharmacy College, Nellore.

OUTLINESDefinitionElectrospinning Process MaterialsApplication in drug delivery

Venkatesh . Y, III/I B.Pharmacy, Narayana Pharmacy College, Nellore

DEFINITION

Nanofibers are the ultra fine solid fibers having very small diameters that is lower than 100nm.

Human hairNanofibersVenkatesh . Y, III/I B.Pharmacy, Narayana Pharmacy College, Nelloredefinition

ELECTROSPINNIG SET UP

213Mainly 3 elements :

1. An Electrical generator or high voltage supplier 2. A Jet source or capillary

3. A metal collector or target Venkatesh . Y, III/I B.Pharmacy, Narayana Pharmacy College, NelloreELECTROSPINNING EQUIPMENT

Electrical generator :A High Voltage Supply (0-40kv) with a low current output was employed in the current study.

Jet source : 2ml glass syringe, needle of different gauge sizes

Metal Collector : copper plate covered with aluminum foil placed at a predetermined distance from the needle tip.

high voltage was discharged by using discharge pen.Venkatesh . Y, III/I B.Pharmacy, Narayana Pharmacy College, Nellore

ELECTROSPINNING apparatusELECTROSPINNIG PROCESS

PRINCIPLE : The process makes use of electrostatic and mechanical force to spin fibers from the tip of the jet source. The solution is usually electrically charged by generator. When the electrostatic repelling force exceeds the surface tension of the polymer solution, the droplet is stretched into a cone ( called taylor cone) and a solution stream is ejected and forms an extremely fine continuous filamentVenkatesh . Y, III/I B.Pharmacy, Narayana Pharmacy College, NelloreOPERATING PROCESS

NanofibersVenkatesh . Y, III/I B.Pharmacy, Narayana Pharmacy College, Nellore

ELECTROSPINNIG POLYMERSNATURALSYNTHETIC Elastin Gelatin Collagen

Polyvinylpyrrolidone Polyglycolic acid (PGA) Polylactic acid (PLA) PGA PLA Polycaprolactone Polydioxanone

Venkatesh . Y, III/I B.Pharmacy, Narayana Pharmacy College, Nellore

Characteristics of NanofibersSurface areaPorosityFlexible & Rigid

Venkatesh . Y, III/I B.Pharmacy, Narayana Pharmacy College, Nellore

APPLICATIONS IN DRUG DELIVERYVenkatesh . Y, III/I B.Pharmacy, Narayana Pharmacy College, Nellore

Recently Nanofibers are used in the healthcare systems, as a tool for drug delivery system in various diseases. The use of Nanofibers proves the importance and convenience of them as drug carriers. The smaller size plays an important role in delivering the drug to the appropriate site in the body. Some properties of Nanofibers which are useful for drug delivery are as follows : A large specific surface area Nanofiber diameter, 1-100nm Venkatesh . Y, III/I B.Pharmacy, Narayana Pharmacy College, Nellore

Protect the drugs from Systemic decompositione.g., in the blood circulation.

Venkatesh . Y, III/I B.Pharmacy, Narayana Pharmacy College, Nellore

Controlled release of the drug at a constant rate over a longer period of time.Drug release only on the targeted body area.Permeate certain membranes or barriers e.g. BBB

Venkatesh . Y, III/I B.Pharmacy, Narayana Pharmacy College, Nellore

Venkatesh . Y, III/I B.Pharmacy, Narayana Pharmacy College, Nellore

Application of water soluble polymer-based nanofibers prepered by eletrostatic spinning as a means of altering the dissolution rate of the poorly water soluble drug, ITRACANAZOLE. The process is organic based solutions of itraconazole/HPMC mixtures were eletrostatically spun at 16 and 24kV.RESEARCH ARTICLE BY GEERT VERRECK. Carbon based nanofibers AKRON Company RESEARCH DRUGSConclusion

Electrospinning is a very simple and versatile method of creating polymer-based high functional and high performance Nanofibers that can revolutionize the world of structural materials. The various approaches should be developed for scientific understanding, engineering control and then potential implementation in devices of Electrospun nanofibers.

MERITSDEMERITS Simple Low energy consumption

Laboratory scale Hazardous organic solvents

Venkatesh . Y, III/I B.Pharmacy, Narayana Pharmacy College, NelloreCONCLUSION

referencesDhaval B. Patel , Rahul Deshmukh,Prashant K. Pawde1, Sandip Tadavi, Rajeshwar V.Kshirsagar; Nanofibers As Drug Delivery System, Journal of Pharmacy Research, 2009, 2(7),1184-1187.2. Audrey Frenot, Ioannis ,S. Chronakis; Polymer nanofibers assembled by electrospinning, Current Opinion in Colloid and Interface Science ,2003 ,8, 6475.3. Thandavamoorthy subbiah, G.S.Bhat, R.W.Tock ; Electrospinning of nanofibers, Journal of Applied Polymer Sciences , 2005, Vol.96,557-569.4. Sangamesh G. Kumbar, Syam P. Nukavarapu, Roshan James, Recent Patents on Electrospun Biomedical Nanostructures; Recent Patents on Biomedical Engineering 2008, 1, 68-78.5. C. K. S. Pillai and Chandra P. Sharma ; Electrospinning of Chitin and Chitosan Nanofibers; Trends Biomater. Artif. Organs, 2009, Vol.22 (3), 179-201.6. www.nano-ram.org7. Google Images20/21Venkatesh . Y, III/I B.Pharmacy, Narayana Pharmacy College, Nellore

THANK YOU