Nitric oxide donor trans-[RuCl([15]aneN)NO] as a possible therapeutic approach for Chagas' disease.

8/6/2019 Nitric oxide donor trans-[RuCl([15]aneN)NO] as a possible therapeutic approach for Chagas' disease.

1/13

TBXBGTHM PGPBT

Fnztnh l}njb jlflt ztgfx% [TrHa-[72UgfbF : .FLU 4 +

gx gplxxndab zmbtgpbrznh gpptlghm ilt Hmgcgx jnxbgxb dpm\239 7&&78Pgral EE Crbjbx 7! Igdngfg X Lanybntg4! Itbj~ TX Crznbttb 7! Ctghb Kbaa~ jg Xnayg7!Cbtxlf Omlfgzgf Tljtncrbx 8! Arxngfb Egtng Dbfjmghk 8! Jlrcagx S Itgfhl : !Egtng G Jl Ygaab Egzzg 2! Jgtnl X _gedlfn 9! Tldbtzl Xgfzgfg jg Xnayg 4 gfj Oll Xgfzgfg Xnayg 7

7 Jbpgtzebfz li Dnlhmbenxzt~ gfj Neerflalc~! Xhmlla li Ebjnhnfb gz Tndbntl Ptbzl! Xl Pgral! Dtg na! 4 Jbpgtzebfz li Hmbenxzt~! Xhmlla li Pmgteghbrznhga Xhnbfhbx gz Tndbntl Ptbzl! Xl Pgral! Dtg na!8 Jbpgtzebfz li Pmgteghlalc~! Xhmlla li Ebjnhnfb gz Tndbntl Ptbzl! Xl Pgral! Dtg na! : Nfxznzrzb li Hmbenxzt~ gz Xl Hgtalx! Xl Pgral! Dtg na!2 Agdltgzlt~ li Hbaaragt

Raztgxztrhzrtb! Lxsgajl Htr Nfxznzrzb%INLHTR_! Tnl jb Ogfbntl! Dtg na! gfj 9

Jbpgtzebfz li Hbaa Dnlalc~! Xhmlla li Ebjnhnfbgz Tndbntl Ptbzl! Rfnybtxnz~ li Xl Pgral! Xl Pgral! Dtg na

Dghkctlrfj gfj prtplxb? Dbf fnjg lab -D . nx zmb zmbtgp~ hrttbfza~ gygnagdab ilt hanfnhga ztbgzebfz li Hmgcgx jnxbgxb&Mlsbybt! egf~ xztgnfx li Zt~pgflxleg htr n pgtgxnzbx gtb fgzrtgaa~ tbxnxzgfz& Fnztnh l}njb -FL. ptljrhbj d~ ghznygzbjeghtlpmgcbx nx htrhnga zl zmb nfztghbaaragt knaanfc li pgtgxnzbx& Mbtb! sb nfybxzncgzb zmbnf ynztl gfj nf ynyl ghznynznbx gcgnfxzZ& htr n ! li zmb FL jlflt! ztgfx%[TrHa-[72UgfbF : .FLU 4+&B}pbtnebfzga gpptlghm? Ztgfx%[TrHa-[72UgfbF : .FLU 4+ sgx nfhrdgzbj snzm g pgtzngaa~ jtrc%tbxnxzgfz Z& htr n ^ xztgnf gfj zmbgfzn%ptlanibtgznyb -bpnegxznclzb ilte. gfj zt~pgflhnjga ghznynznbx -zt~plegxznclzb gfj gegxznclzb. bygargzbj& Enhb sbtb ztbgzbjjrtnfc zmb ghrzb pmgxb li Hmgcgx jnxbgxb& Zmb gfzn%Z& htr n ghznynz~ sgx bygargzbj d~ pgtgxnzgbeng! xrtynyga tgzb! hgtjnghpgtgxnznxe! e~lhgtjnznx gfj zmb hrtgznyb tgzb&Kb~ tbxrazx? Ztgfx%[TrHa-[72UgfbF : .FLU 4+ sgx 70% gfj 700%ilaj eltb ghznyb zmgf D gcgnfxz gegxznclzbx gfj zt~plegxznclzbxtbxpbhznyba~& Irtzmbt!ztgfx%[TrHa-[72UgfbF : .FLU 4+ -0&7 eE. nfjrhbj 700" li zt~pgflhnjga ghznynz~ -zt~plegxznclzbx iltex.

nf ynztl&Ztgfx %[TrHa-[72UgfbF: .FLU4+

nfjrhbj pbtegfbfz xrpptbxxnlf li pgtgxnzgbeng gfj 700" xrtynyga nf g ertnfb eljba li ghrzb Hmgcgx jnxbgxb& Smbf zmb jtrcx sbtb cnybf galfb! pgtgxnzlalcnhga hrtbx sbtb hlf tebj nf lfa~ 80 gfj :0" li zmbgfnegax ztbgzbj snzm zmb FL jlflt -8&88 e elakc %7jg~ %7. gfj D -8=2 e elakc %7jg~ %7.! tbxpbhznyba~! drz smbf cnybfzlcbzmbt! =0" li zmb gfnegax sbtb pgtgxnzlalcnhgaa~ hrtbj& Zmb hrtbj gfnegax xmlsbj gf gdxbfhb li e~lhgtjnznx gfj gflteganxgznlf li h~zlknfb ptljrhznlf nf zmb xbtg& Nf gjjnznlf! fl nf ynztl zl}nhnz~ sgx ldxbtybj gz zmb zbxzbj jlxbx&Hlfharxnlfx gfj nepanhgznlfx? Zmbxb fjnfcx nfjnhgzb zmgzztgfx%[TrHa-[72UgfbF : .FLU 4+ nx g ptlenxnfc abgj hleplrfj ilt zmb ztbgzebfz li mregf Hmgcgx jnxbgxb&Dtnznxm Olrtfga li Pmgteghlalc~ -4070. jln?70&7777,o&7:39%28=7&400>&00239&}

Kb~sltjx? FL jlfltx; ztgfx%[TrHa-[72UgfbF : .FLU 4+; dbf fnjg lab; Zt~pgflxleg htr n ; Hmgcgx jnxbgxb

Gddtbyngznlfx? :%pnh! :%pnhlanfb; GG! gxhltdnh ghnj; GDZX! -4!4%g nfl%jn%-8%bzm~a dbf zmng lanfb%9%xrapmlfnh ghnj.; DEJE!dlfb egttls%jbtnybj eghtlpmgcbx; DZ! dalljxztbge zt~plegxznclzb iltex li Zt~pgflxleg htr n ; D ! dbf%

fnjg lab; JGI%4 JG! :!2%jngenflfflrltbxhbnf jnghbzgzb; JGI%4Z! JGI%4 ztng lab; JEBE! Jradbhhlx eljn bj

Bgcabx ebjnre; IDX! ibzga dlynfb xbtre; IN! fflrltbxhbfhb nfzbfxnz~; INZH! fflrltbxhbnf nxlzmnlh~gfgzb; NIF%c !nfzbtibtlf%c ; NA! nfzbtabrknf; neH! nenjg lab hlltjnfgzbj d~ hgtdlf; neF! nenjg lab hlltjnfgzbj d~ fnztlcbf;nfg! nxlfnhlznfnh ghnj; nxf! nxlfnhlznfgenjb; A%mnxz! A%mnxznjnfb; ANZ! anybt nfirxnlf zt~pzlxb; APX! anplpla~xghhmg%tnjb; FI%kd ! frhabgt ighzlt%kd ; FMB! fltega m~jtlcbf babhztljb; fnh! fnhlznfgenjb; PDX! pmlxpmgzb driibtbjxganfb; PHT! pla~ebtgxb hmgnf tbghznlf; PB! pm~hlbt~zmtnf; p~! p~tnjnfb; p ! p~tg nfb; XFP! xljnre fnztlptrx%xnjb; Z& htr n ! Zt~pgflxleg htr n ; ZCI%d! ztgfxiltenfc ctlszm ighzlt d; ZFI%g ! zrelrt fbhtlxnx ighzlt% g

Nfztljrhznlf

Zt~pgflxleg htr n nx gf nfztghbaaragt ptlzl lgf zmgz nx gdab zlhgrxb mregf jnxbgxb gfj hlfxznzrzbx g egolt hgrxb li mbgtz

jnxbgxb nf Agznf Gebtnhg& Nf Hbfztga gfj Xlrzm Gebtnhg!Hmgcgx jnxbgxb giibhzx 78 enaanlf pblpab! snzm 32 enaanlf gz

Hlttbxplfjbfhb? Pgral EE Crbjbx! Jbpgtzebfz li Dnlhmbenxzt~ gfj Neer%flalc~! Xhmlla li Ebjnhnfb gz Tndbntl Ptbzl! Agdltgzlt~ li Neerflpgtgxnzla%lc~! Rfnybtxnz~ li Xl Pgral! Gybfrb jlx Dgfjbntgfzbx 8>00! Elfzb Gabctb!7:0:>%>00 Tndbntl Ptbzl! Xl Pgral! Dtg na& B%egna? pgralcrbjbx@rxp&dt Tbhbnybj 70 Gptna 400>; tbynxbj 44 Xbpzbedbt 400>; ghhbpzbj 7 Lhzldbt 400>

Dtnznxm Olrtfga li Pmgteghlalc~ -4070.! ! 4070 Zmb GrzmltxOlrtfga hlepnagznlf 4070 Zmb Dtnznxm Pmgteghlalcnhga Xlhnbz~ Gaa tncmzx tbxbtybj 000sss&dtopmgteghla&ltc


2/13

tnxk ilt nfibhznlf -SML! 4002.& Eltblybt! ztgfxenxxnlfzmtlrcm ztgfxirxnlfx gfj ztgfxpagfzx tbptbxbfzx g prdanhmbgazm hlfhbtf nf flf%bfjbenh hlrfztnbx xrhm gx Grxztgang!Hgfgjg! Xpgnf gfj zmb Rfnzbj Xzgzbx -Xhmerfnx! 4003.& Zmbhrttbfz gfzn%pgtgxnznh hmbelzmbtgp~ snzm dbf fnjg lab -D .

-Tlhmgcgf gfj Tljgfna; Tlhmb! Tnl jb Ogfbntl! Dtg na. ltfnirtznel} -Agepnz; Dg~bt! Srppbtzga! Cbtegf~. nx tbagznyba~biibhznyb jrtnfc zmb ghrzb gfj xrd%hmtlfnh xzgcbx li Hmgcgxjnxbgxb -Trxxlegfjl bz ga&! 7>>=; Xlxg Bxzgfn bz ga&! 7>>=;Hgfhgjl! 4004; Gazhagx bz ga&! 4002.& Zmb gjbwrgh~ li gfzn%pgtgxnznh ztbgzebfz ilt pgznbfzx nf zmb nfjbzbtenfgzb g fjhmtlfnh xzgcbx li zmb jnxbgxb mgx flz dbbf hlf tebj& Xlebflf%tgfjlenxbj xzrjnbx mgyb xrccbxzbj zmgz zt~pgflhnjgaztbgzebfz snzm D xalsbj zmb ptlctbxxnlf li zmb hanfnhga hlf%jnznlf gfj hgtjngh irfhznlf! gx nfjnhgzbj d~ zmb ptbybfznlf li sltxbfnfc BHC! li zmb pgznbfzx -Ynlzzn bz ga&! 7>>:; 4009;Igddtl Jb Xrgxfgdgt bz ga&! 4000; Agrtng%Pntbxbz ga&! 4000.!smnab lzmbtx ~nbajbj nfhlfharxnyb tbxrazx -Agrtng%Pntbx bz ga&!

4000.& Rfiltzrfgzba~! D ztbgzebfz nx rfxgznxighzlt~ jrtnfczmb hmtlfnh pmgxb li zmb jnxbgxb& Zmbtbiltb! zmb jbybalpebfzli fbs jtrcx nx fbhbxxgt~&

Pgtgxnzb banenfgznlf jbpbfjx agtcba~ lf zmb ptljrhznlf li ptl%nffflgeegzlt~ h~zlknfbx! xrhm gx nfzbtibtlf% c -NIF%c .!zrelrt fbhtlxnx ighzlt% g -ZFI%g . gfj nfzbtabrknf -NA.%74! gxzmb~ ghz nf hlfhbtz zl ghznygzb eghtlpmgcbx zmgz knaa nfztghba%aragt pgtgxnzbx zmtlrcm zmb ptljrhznlf li fnztnh l}njb -FL.gfj nzx jbtnybj fnztlcbf gfj l}~cbf tgjnhgax -Gandbtzn bz ga&!7>>>; 4007; Eghmgjl bz ga&! 4000.& Xzrjnbx rxnfc b}pbtnebfzgaeljbax li ghrzb nfibhznlf mgyb jbelfxztgzbj zmgz zmb gfzn%pgtgxnznh ghznynz~ li D nfylaybx zmb pgtznhnpgznlf li zmbxbh~zlknfbx -Enhmgnalsxk~ bz ga&! 7>>=; Elanfg bz ga&! 4000. gxsbaa gx hlygabfz eljn hgznlfx li eghtlelabhrabx d~ nfzbteb%jngzbx li fnztl%tbjrhbtx -tbjrhznyb xztbxx. -Jlhgepl! 7>>0.&Hlfybtxba~! fnirtznel} ghzx d~ tbjrhnfc zmb fnztl ctlrp zlilte rfxzgdab fnztl gfnlf tgjnhgax! smnhm! nf zrtf! tbghz zlptljrhb mncma~ zl}nh tbjrhbj l}~cbf ebzgdlanzbx! xrhm gxxrpbtl}njb gfnlf gfj m~jtlcbf pbtl}njb -Jlhgepl! 7>>0.&

Dlzm D gfj fnirtznel} mgyb xncfn hgfz xnjb biibhzx! nfharj%nfc gfltb}ng! ylenznfc! pbtnpmbtga pla~fbrtlpgzm~ gfj gaabt%cnh jbtelpgzm~ -Tgxxn bz ga&! 7>>>.& Eltblybt! xbybtga xztgnfxli Z& htr njl flz tbxplfj zl zmbxb ztbgzebfzx! bybf jrtnfc zmbghrzb pmgxb li zmb jnxbgxb -Inagtjn gfj Dtbfbt! 7>=3; Cgayglbz ga&! 7>>8; Rtdnfg! 7>>>.& Zmb tgzb li hrtb ldxbtybj nfpgznbfzx snzm zmbxb jtrcx nx 2030" jrtnfc zmb ghrzb pmgxbgfj 040" jrtnfc zmb hmtlfnh pmgxb -Crbjbx bz ga&! 4009.&Zmnx xnzrgznlf nx xbybtba~ gcctgygzbj d~ zmb gdxbfhb li g clajxzgfjgtj ilt jngcflxnx! smnhm zmtlsx jlrdz lf gaa zmb pgtge%bzbtx rxbj ilt bygargznfc zmb lrzhleb li zt~pgflhnjga zmbtg%pnbx& Zmrx! zmbtb nx gf nepbtgznyb tbwrntbebfz ilt zmbjbybalpebfz li fbs zmbtgpbrznh gcbfzx ilt Hmgcgx jnxbgxb&

Trzmbfnre FL jlflt hleplrfjx mgyb tbhbfza~ bebtcbjgx gf nfzbtbxznfc gfj nepltzgfz gazbtfgznyb ztbgzebfz li b}pbtnebfzga nfibhznlfx snzm Z& htr n-Xnaygbz ga&! 4003.& Zmbxbhleplrfjx xmlsbj als zl}nhnznbx nf ynztl gfj nf ynyl gfjxzgdnanz~ nf gwrblrx ebjng nf zmb ptbxbfhb li l}~cbf gfj FL!smnhm gtb tbabgxbj d~ tbjrhnfc gcbfzx ptbxbfz nf zmb mlxzbfyntlfebfz -Dlcjgf! 4007; Xnayg bz ga&! 4003.& Lrt ctlrptbhbfza~ tbpltzbj zmb zt~pgflhnjga ghznynz~! nf ynztl gfj nf ynyl!

li g xbtnbx li trzmbfnre fnztlx~ax! nfharjnfc ztgfx %[Tr NN-FL +.-FM 8. : AU]8! A5 nenjg lab -nenjg lab hlltjnfgzbj d~

fnztlcbf -neF. lt nenjg lab hlltjnfgzbj d~ hgtdlf! p~tnjnfb!A%mnxznjnfb! xrapmnzb -XL84%.! p~tg nfb! fnhlznfgenjb! :%pnhlanfb! ztnbzm~apmlxpmnzb -[P-LBz.8U.! nxlfnhlznfgenjb -nxf.!nxlfnhlznfnh ghnj! ] 5 DI : %! Ha% lt PI 9%! gfj [Tr NN-FL +.-Mbjzg.Ugcgnfxz zmb ^ xztgnf li Z& htr n& Xrhm hleplrfjx sbtb bi hnbfz

nf tbjrhnfc dlzm pgtgxnzgbeng gfj hgtjngh nffflgeegznlf! gfjgaxl abj zl zmb zlzga xrtynyga li nfibhzbj enhb zmgz sbtb ztbgzbj-Xnaygbz ga&! 4003.& Zmb zmbtgpbrznh xhmbjrab! mlsbybt! sgxrxbj lfa~ ilt 72 jg~x li ztbgzebfz gfj jnj flz ilhrx lf zmbbygargznlf li pgtgxnzlalcnhga hrtb& Mbtb! sb rxbj g fbs gfjeltb plzbfz FL jlflt! ztgfx %[TrHa-[72UgfbF: .FLU 4+ hlepab}-[72UgfbF : 5 7!:!=!74%zbztgg gh~halpbfzgjbhgfb! g eghtlh~%hanh wrgjtnjbfzgzb genfb ancgfj.! lybt g zmbtgpbrznh xhmbjrabli 40 jg~x li ztbgzebfz nf enhb nfibhzbj snzm zmb ^ xztgnf li Z& htr n& Zmb pgtgxnzlalcnhga hrtb li enhb ztbgzbj snzm ztgfx%[TrHa-[72UgfbF : .FLU 4+ sgx bygargzbj gfj hlepgtbj snzm zmgzgizbt ztbgzebfz snzm D ! gx sbaa gx gizbt g hlednfgznlf li dlzm jtrcx&

Ebzmljx

Pgtgxnzb gfj b}pbtnebfzga nfibhznlfZmb ^ xztgnf li Z& htr nsgx rxbj nf gaa b}pbtnebfzx -Xnayg gfjFrxxbf sbnc! 7>28.& Enhb sbtb nfibhzbj d~ n&p& nfobhznlf snzm7 70 8 dallj zt~plegxznclzb xzgcbx li Z& htr n& Hrazrtb zt~pl%egxznclzbx sbtb ldzgnfbj itle g dtldagxz hbaa anfb -AAH%EK 4.& Bpnegxznclzb iltex sbtb ldzgnfbj jrtnfc zmbb}plfbfznga pmgxb li ctlszm nf anybt nfirxnlf zt~pzlxb -ANZ.ebjnre&

Fnztnh l}njb ebgxrtbebfz nf dlfb egttls%jbtnybj eghtlpmgcbxDlfb egttls%jbtnybj eghtlpmgcbx -DEJE. sbtb cbfbtgzbjitle dlfb egttls xzbe hbaax zmgz sbtb hrazrtbj gx ptbynlrxa~jbxhtndbj -Hbagjg bz ga&! 7>=:.& Zmbxb hbaax sbtb zmbf algjbjsnzm zmb xbabhznyb FL fflrltbxhbfz j~b :!2%jngenflfflrltbxhbnfjnghbzgzb -JGI%4 JG. -70 e E. ilt 80 enf gz tlle zbepbtgzrtb-Tljtncrbx bz ga&! 400=.& Zmb ebedtgfb pbtebgdab JGI%4 JGtbgjna~ bfzbtx zmb hbaax gfj nx xrdxbwrbfza~ m~jtla~xbj d~h~zlxlanh bxzbtgxbx zl tbabgxb itbb JGI%4! smnhm jlbx flzabgyb zmb hbaa& Gz pm~xnlalcnhga pM! JGI%4 nx tbagznyba~flf%fflrltbxhbfz! drz nz iltex zmb fflrltbxhbfz ptljrhz JGI%4ztng lab -JGI%4Z. nf zmb ptbxbfhb li FL gfj l}~cbf& Zmnxgpptlghm gaalsx zmb jntbhz ynxrganxgznlf gfj xben%wrgfznzgznyb gfga~xnx li zmb dgxga FL gygnagdnanz~ gz zmb hbaar%agt abyba& Zmb b}hbxx j~b sgx tbelybj d~ sgxmnfc nf g dgzmxlarznlf& Zmb h~zlxlanh FL hlfhbfztgznlf sgx gxxbxxbj d~ gAbnhg ZHX XP2 xpbhztga xhgffnfc hlfilhga enhtlxhlpb -AbnhgEnhtlx~xzbex! Sbz agt! Cbtegf~.& JGI%4Z fflrltbxhbfhb sgxb}hnzbj snzm zmb :== me anfb li gf gtclf nlf agxbt! gfj zmbbenzzbj fflrltbxhbfhb sgx ebgxrtbj gz 272 me& Zneb hlrtxbxlizsgtb sgx rxbj zl hgpzrtb negcbx li zmb hbaax gz 4 x nfzbtygaxrxnfc zmb Anyb Jgzg Eljb ghwrnxnznlf& Zmb nfzbfxnznbx li zmbnfztghbaaragt eg}nere lt enfnere fflrltbxhbfhb sbtb ebg%xrtbj zmtlrcm zmb gppanhgznlf li zmb AXHE hleprzbt xliz%sgtb& Itle zmbxb jgzg! zmb dgxga fflrltbxhbfhb nfzbfxnz~ ygarb

-dgxga. sgx tbcnxzbtbj gz zneb btl li zmb b}pbtnebfz& Zmb fgaIN ygarb -72%gfb. sgx tbcnxzbtbj gz 800 x gizbt zmb gjjnznlf li

FL jlflt zmbtgp~ ilt Hmgcgx jnxbgxb4 PEE Crbjbx bz ga

Dtnznxm Olrtfga li Pmgteghlalc~ -4070.


3/13

dlzm ztgfx%[TrHa-[72UgfbF : .FLU 4+. -7 eE. gfj zmb tbjrhnfcgcbfz pmbf~abpmtnfb -0&7 e E. zl zmb ebjnre&

Hrazrtb li elrxb abrkgbenh elflh~zb eghtlpmgcb hbaa anfb49:&3 eghtlpmgcbx gfj arhnibtgxb gxxg~xZmb ertnfb elrxb abrkgbenh elflh~zb eghtlpmgcb hbaa anfb-TGS. 49:&3 Arh eghtlpmgcb! dbgtnfc zmb arhnibtgxb ybhzltnfxbtzbj nf zmb FI%k D ptlelzbt -pFI% k D%Arh.! sgx tlrznfba~hrazrtbj nf Jradbhhlx eljn bj Bgcabx ebjnre xrppab%ebfzbj snzm 70" ibzga dlynfb xbtre -IDX. gfj pbfnhnaanf%xztbpzle~hnf! gz 83H nf g mrenjn bj gzelxpmbtb li 2" HL 4&Ilt arhnibtgxb tbpltzbt gxxg~x! TGS 49:&3 eghtlpmgcbx -2 70 2 hbaaxeA%7. sbtb ctlsf nf 4:%sbaa pagzbx zl 9030" hlf%fflrbfhb& Gizbt hrazrtnfc ilt 4: m! hbaax sbtb xzneragzbj snzmanplpla~xghhmgtnjb -7 e ceA %7. ilaalsnfc zmb gjjnznlf li ztgfx%[TrHa-[72UgfbF : .FLU 4+ -7&0! 0&2 gfj 0&7 eE.! gxhltdnhghnj -GG; 7&0! 0&2 gfj 0&7 eE. gfj D -7&0 eE. zl zmb ctlszmebjnre& Hbaax sbtb ztbgzbj gz jniibtbfz jtrc hlfhbfztgznlfx

gfj kbpz lybtfncmz rfjbt nfhrdgznlf hlfjnznlfx& Hbaax sbtbmgtybxzbj gfj b}ztghzbj nf a~xnx driibt -ZFZ.! gfj zmbarhnibtgxb ghznynznbx nf zmb hbaa a~xgzbx sbtb jbzbtenfbj rxnfczmb Jrga Arhnibtgxb Tbpltzbt gxxg~ x~xzbe -Ptlebcg.& Jgzgsbtb zmbf b}ptbxxbj gx g tgznl li ancmz rfnzx&

Xrtighb elabhrab b}ptbxxnlf gfj h~zlzl}nhnz~ li ztbgzbj eghtlpmgcbZmb b}ptbxxnlf li hl%xzneragzlt~ elabhrabx -HJ:0! HJ=0 gfjHJ=9. gfj EMH%NN sgx gxxbxxbj nf DEJE gizbt dbnfc nfhr%dgzbj ilt 4: m snzm ztgfx%[TrHa-[72UgfbF : .FLU 4+& Xrtighbxzgnfnfc li rfztbgzbj% gfj jtrc%ztbgzbj eghtlpmgcbx sgx pbt%iltebj! nf bghm hgxb! d~ hbaa nfhrdgznlf snzm xpbhn h

pm~hlbt~zmtnf% lt fflrltbxhbnf nxlzmnlh~gfgzb%agdbaabj elfl%halfga gfzndljnbx? gfzn%HJ:0! gfzn%HJ=9! gfzn%HJ=9 gfjgfzn%EMH%NN -DJ%Pmgtenfcbf! Xgf Jnbcl! HG! RXG.& Ilt h~zl%zl}nhnz~ gxxg~x! ztnpanhgzbx li DEJE sbtb nfhrdgzbj snzmztgfx%[TrHa-[72UgfbF : .FLU 4+ -0&7! 0&2 gfj 7&0 eE. gfj,lt GG-0&7! 0&2 gfj 7&0 eE. jnarzbj nf pmlxpmgzb driibtbj xganfb-PDX. gz 83H nf g mrenjn bj gzelxpmbtb li 2" HL 4 ilt 4: m&D -7&0 eE. sgx rxbj gx zmb tbibtbfhb zt~pgflhnjga jtrc! gfjZsbbf 40 -2&0! 0&2! gfj 0&002". sgx rxbj gx g plxnznyb hlfztlailt zmb jbgzm li hbaax& Hbaax sbtb mgtybxzbj gfj nfhrdgzbj snzmptlpnjnre nljnjb gz 20 e ceA %7& Jgzg sbtb ghwrntbj gizbt72 enf! rxnfc g IGHXltzbt gppgtgzrx -Dbhzlf%JnhknfxlfNeerflh~zlebzt~ X~xzbe Nfh&! Xgf Olxb! HG! RXG.& Erazn%

ygtngzb jgzg gfga~xnx sgx pbtiltebj nf zmb IalsOl xlizsgtb-Gxmagfj! LT! RXG.&

Nf ynyl abzmga jlxb li ztgfx%[TrHa-[72UgfbF : .FLU 4+

Ilt zmb jbzbtenfgznlf li zmb mgai%abzmga jlxb -AJ 20 . nf ynyl!zmtbb Xsnxx enhb -80 c. pbt ctlrp sbtb nfobhzbj d~ n&p& nfobh%znlf snzm ztgfx%[TrHa-[72UgfbF : .FLU 4+ lt GG parx ztgfx%[TrHa-[72UgfbF : .FLU 4+ jnarzbj nf PDX gz jlxbx li =8! 420! 320!4000 gfj 9000 e elakc %7! tbxpbhznyba~! snzm gfnega xrtynygaldxbtybj lybt zmb hlrtxb li := m! gx ptbynlrxa~ jbxhtndbj-Xnaygbz ga&! 4003.&

Zt~pgflhnjga ghznynz~ li ztgfx%[TrHa-[72UgfbF : .FLU 4+ nf ynztl

Zmb nf ynztl gfzn%ptlanibtgznyb gfj zt~pgflhnjga ghznynznbx li ztgfx%[TrHa-[72UgfbF : .FLU 4+ sbtb nfnzngaa~ bygargzbj gcgnfxz

zmb bpnegxznclzb gfj zt~plegxznclzb iltex! tbxpbhznyba~! li zmb Z& htr n xztgnfx! gx ptbynlrxa~ jbxhtndbj -Xnayg bz ga&!4003.& Zt~plegxznclzb gfj bpnegxznclzb hrazrtbx sbtbtb%xrxpbfjbj gz g hlfhbfztgznlf li 9&2 70 9 pgtgxnzbxeA %7 nfTlxsbaa Pgtk Ebeltnga Nfxznzrzb -TPEN. ebjnre snzm 70"

IDX gfj ANZ! tbxpbhznyba~& Ztnpanhgzb hrazrtbx sbtb ztbgzbj snzmztgfx%[TrHa-[72UgfbF : .FLU 4+ -0&7! 0&2 gfj 7&0 eE. gfj,lt GG-0&7! 0&2 gfj 7&0 eE. jnarzbj nf PDX gz 83H nf g mrenjn bjgzelxpmbtb li 2" HL 4& D -7&0 eE. -Tlhmb. sgx rxbj gx zmbtbibtbfhb zt~pgflhnjga jtrc -plxnznyb hlfztla.& Pgtgxnzb yngdna%nz~ sgx xrdxbwrbfza~ zbxzbj d~ jbzbtenfnfc zmb fredbt li elznab iltex! ghhltjnfc zl zmb ebzmlj bxzgdanxmbj d~ Dtbfbt-7>94d.& Zmb hlfhbfztgznlf li hleplrfj hlttbxplfjnfc zl20" gfzn%ptlanibtgznyb lt zt~pgflhnjga ghznynz~ gizbt 4: m li nfhrdgznlf sgx b}ptbxxbj gx zmb NH 20bpn -nfmndnzlt~ hlfhbfztg%znlf ilt zmb bpnegxznclzb ilte. lt NH 20zt~ -nfmndnzlt~ hlfhbf%ztgznlf ilt zmb zt~plegxznclzb ilte.! tbxpbhznyba~& Zmb xgebptlzlhla sgx rxbj zl jbzbtenfb zmb zt~pgflhnjga ghznynz~ li

zmb gwrblrx hlepab}! ztgfx%[TrHa-[72UgfbF : .M4LU+

&Zmb nfztghbaaragt ghznlf li zmb jtrcx sgx gaxl jbzbtenfbj lfzmb gegxznclzb iltex& Xrdhlffflrbfz elflag~btx li Ybtl hbaax-Gebtnhgf Z~pb Hrazrtb Hlaabhznlf HAA%=7. sbtb pagzbj gz7&42 70 : hbaax nf TPEN -CNDHL! Ctgfj Nxagfj! F ! RXG.xrppabebfzbj snzm 2" IDX -Frztnhbaa! Hgepnfgx! Xl Pgral!Dtg na. nf bghm sbaa li g bncmz%sbaa hmgedbt xanjb -hmgedbtxanjb! Frfh Nfh&! Fgpbtynaab! NA! RXG. gfj nfhrdgzbj gz 83H nfg mrenjn bj gzelxpmbtb li 2" HL 4 ilt 4: m ptnlt zl nfibh%znlf& Hbaa xrdhlffflrbfz elflag~btx sbtb zmbf nfibhzbj snzmznxxrb hrazrtb zt~plegxznclzb iltex -74&2 70 : pgtgxnzbx pbtsbaa. ilt 4: m& Gizbt nfibhznlf! zmb hmgedbt xanjbx sbtb sgxmbjzsnhb snzm hlaj PDX nf ltjbt zl tbelyb pgtgxnzbx gjmbtnfc zlzmb lrzxnjb li hbaax! gfj zmb hbaax sbtb zmbf tb%nfhrdgzbj nfhrazrtb ebjnre snzm jtrc zbxzbj& Zmbxb b}pbtnebfzx sbtbpbtiltebj nf ztnpanhgzb& Zmb ebjng sgx tbelybj gizbt 4: mnfhrdgznlf snzm jtrc gfj zmb hmgedbt sgx xzgnfbj snzmCnbexg! gx ptbynlrxa~ jbxhtndbj -Crbjbx bz ga&! 4003.& Zmbpbthbfz li nfibhzbj hbaax sgx jbzbtenfbj d~ tgfjlea~ b}ge%nfnfc zmb xanjbx gfj hlrfznfc g enfnere li 200 hbaax rfjbtzmb enhtlxhlpb rxnfc mncm egcfn hgznlf -:00 .&

Ztbgzebfz li enhb snzm FL jlflt gfj DGaa gfnega hgtb gfj b}pbtnebfzga ptlzlhlax sbtb gpptlybj d~zmb Bzmnhx Hleenzzbb lf Gfnega Tbxbgthm li zmb Rfnybtxnz~li Xl Pgral& Zmb enhb zmgz sbtb rxbj nf zmbxb b}pbtnebfzxdbalfcbj zl zmb gfnega xzlhk li zmb Jbpgtzebfz li Dnlhmbe%nxzt~ gfj Neerflalc~! Ebjnhnfb Xhmlla li Tndbntl Ptbzl gzzmb Rfnybtxnz~ li Xl Pgral nf Xl Pgral! Dtg na& Gfnegax sbtbmlrxbj nf zbepbtgzrtb%hlfztlaabj tllex -4442H. gfjtbhbnybj sgzbt gfj illj gj andnzre nf zmb gfnega ighnanznbx&Ibegab Xsnxx enhb 9= sbbkx laj sbtb nfibhzbj snzm 7&0 70 8

dallj zt~plegxznclzbx pbt gfnega& G zlzga li bncmz b}pbtnebf%zga ctlrpx! bghm hlfxnxznfc li 70 Xsnxx enhb zmgz sbncmbj4280 c! sbtb rxbj& Ztbgzebfz xzgtzbj xllf gizbt zmb jbzbhznlfli pgtgxnzgbeng! smnhm lhhrttbj lf jg~ : plxz nflhragznlf-p&n&.& D ! nf g xrxpbfxnlf nf :" cre gtgdnhg! sgx gjenfnx%zbtbj ltgaa~ gz 8=2 e elakc %7 li dlj~ sbncmz pbt jg~-bwrnygabfz zl 700 eckc %7. ilt 40 hlfxbhrznyb jg~x& Ztgfx%

[TrHa-[72UgfbF : .FLU 4+ -8&88e elakc %7jg~ %7. gfj GG-8&88e elakc %7jg~ %7. jnarzbj nf PDX sbtb cnybf d~ n&p&

FL jlflt zmbtgp~ ilt Hmgcgx jnxbgxbPEE Crbjbx bz ga 8



4/13

nfobhznlf ilt 40 hlfxbhrznyb jg~x& Zmb ctlrpx tbhbnybj zmbilaalsnfc ztbgzebfzx? Ctlrp 7 5 PDX! Ctlrp 4 5 GG! Ctlrp8 5 D ! Ctlrp : 5 ztgfx%[TrHa-[72UgfbF : .FLU 4+! Ctlrp 2 5ztgfx%[TrHa-[72UgfbF : .FLU 4+ parx D ! Ctlrp 9 5 ztgfx%[TrHa-[72UgfbF : .FLU 4+ parx GG! Ctlrp 3 5 ztgfx%

[TrHa-[72UgfbF : .FLU 4+

parx D parx GG gfj Ctlrp = 5 flznfibhzbj gfj flz ztbgzbj& Zbf gfnegax itle bghm ctlrp sbtbknaabj gz zmb bfj li zmb ztbgzebfz -42 jg~x p&n. ilt wrgfzn %hgznlf li zmb abybax li mbgtz nffflgeegznlf gfj h~zlknfb ptl%jrhznlf& Gflzmbt 70 gfnegax sbtb rxbj zl bygargzbpgtgxnzgbeng! eltzganz~ gfj pgtgxnzlalcnhga hrtb& Zmb bygarg%znlf li pgtgxnzgbeng sgx pbtiltebj gx ptbynlrxa~ jbxhtndbj-Dtbfbt! 7>94g.&

H~zlknfb wrgfzn hgznlf d~ BANXGZmb h~zlknfb abybax nf xbtre xgepabx ldzgnfbj lf jg~ 42 p&n&sbtb jbzbtenfbj rxnfc BANXG knzx ilt NA%70! NIF%c gfj ZFI% g-gaa T)J Jrlxbz! T)J! Enffbgplanx! EF! RXG.! ghhltjnfc zlzmb egfrighzrtbtx nfxztrhznlfx& Zmb tbghznlf sgx jbzbhzbj d~pbtl}njgxb%hlforcgzbj xztbpzgynjnf ilaalsbj d~ g xrdxztgzben}zrtb hlfzgnfnfc m~jtlcbf pbtl}njb gfj GDZX -XncegGajtnhm! Xz& Alrnx! EL! RXG. gx g hmtlelcbf&

Fnztnzb ebgxrtbebfz nf zmb xbtg li ztbgzbj gfnegaxFnztnzb ptljrhznlf nf zmb xbtg li flf%nfibhzbj gfj nfibhzbjenhb sgx ebgxrtbj d~ ghhreragznlf li fnztnzb! smnhm nx g FLebzgdlanzb! nf xbtg hlaabhzbj lf jg~ 42 p&n -zmb agxz jg~ li ztbgzebfz.! gx jbxhtndbj ptbynlrxa~ -Ctbbf bz ga&! 7>=7.&Dtnbffl~! 0&02 eA li Ctnbxx tbgcbfz [0&7" fgpmzm~a bzm~abfbjn%genfb -Xnceg Gajtnhm. gfj 7" xraigfnagenjb nf 4&2" pmlx%

pmltnh ghnj -Xnceg Gajtnhm.U sgx gjjbj zl 0&02 eA li xbtg!gfj gdxltdgfhb sgx tbgj gz 2:0 fe rxnfc gf grzlegzbj pagzbtbgjbt& Fnztnzb hlfhbfztgznlf sgx hgahragzbj itle g FgFL 4xzgfjgtj hrtyb&

Bygargznlf li pgtgxnzlalcnhga hrtbPgtgxnzlalcnhga hrtb sgx gxxbxxbj d~ g dgzzbt~ li zmtbb nfjb%pbfjbfz zbxzx! pbtiltebj 80 jg~x gizbt zmb bfj li ztbgzebfz!zmgz nx! 22 jg~x p&n! nfharjnfc pgtgxnzlalcnhga gxxg~x! xrhm gxmgbelhrazrtb gfj tbga%zneb PHT! gfj xbtlalcnhga gxxg~x! xrhmgx BANXG& Zmb pgtgxnzlalcnhga hrtb sgx jbzbtenfbj dgxbjrplf g fbcgznyb tbxraz snzm dlzm zmb pgtgxnzlalcnhga gfjxbtlalcnhga ebzmljx&

Zmb mgbelhrazrtb gxxg~ sgx pbtiltebj gx ilaalsx& Gfnegaxsbtb dabj itle zmb ltdnzga ybflrx xnfrx! gfj :00 e A li dalljsbtb hlaabhzbj gfj jnynjbj nfzl zsl zrdbx hlfzgnfnfc 8 eA li ANZ ebjnre& Zrdbx sbtb nfhrdgzbj gz 4=H ilt >0 jg~x gfjb}genfbj elfzma~ ilt zmb ptbxbfhb li pgtgxnzbx -Hgajgx bz ga&!400=.&

Tbga%zneb PHT sgx pbtiltebj rxnfc zmb Pagznfre X^DTCtbbf wPHT XrpbtEn} RJC snzm TL] x~xzbe -Nfynztlcbf!Hgtaxdgj! HG! RXG.& Zmb tbghznlf en} nfharjbj 4 e c li JFGparx 42 pela li ptnebtx X 82 -2GGGZGGZCZGHCCC -Z,C.CGCGZCHGZCG8 . gfj X 89 -2CCCZZHCGZZCCCCZZC%CZCZ8 . -LPBTLF Zbhmflalcnbx! NFH.& Xgepabx sbtb gepan%

bj ilt :0 h~habx nf g 3000 Xbwrbfhb Jbzbhznlf X~xzbex

-Gppanbj Dnlx~xzbex! Ilxzbt Hnz~! HG! RXG.! smnhm cbfbtgzbj gptljrhz li 880 dp&

BANXG gfj fflls h~zlebzt~ sbtb pbtiltebj snzm xbtgldzgnfbj lf zmb txz elfzm gizbt ztbgzebfz& BANXG pagzbx sbtbhlgzbj snzm Z& htr ngfzncbf zmgz sgx ptbpgtbj itle gakganfbb}ztghznlf li zmb Z& htr n xztgnf jrtnfc zmb b}plfbfzngapmgxb li ctlszm nf ANZ ebjnre& Gfzn%elrxb NcC%pbtl}njgxb

hlforcgzbj gfzndlj~ -Xnceg Gajtnhm. sgx rxbj& Zmb ebgfgdxltdgfhb ilt 70 fbcgznyb hlfztla xgepabx parx zsl xzgfjgtjjbyngznlfx sbtb rxbj gx zmb hrz%lii zl jnxhtnenfgzb dbzsbbfplxnznyb gfj fbcgznyb tbxrazx&

Wrgfzn hgznlf li e~lhgtjnga nffflgeegznlfE~lhgtjnznx sgx gxxbxxbj gx ptbynlrxa~ jbxhtndbj -Crbjbxbz ga&! 4003.& Dtnbffl~! zlzga frhabn fredbtx sbtb jbzbtenfbj nf20 enhtlxhlpnh bajx! rxnfc gz abgxz ilrt tbptbxbfzgznyb! flf%hlfxbhrznyb! mgbegzl}~anf gfj blxnf%xzgnfbj xbhznlfx -zmnhk%fbxx li 2 e e. itle bghm elrxb& Xbhznlfx sbtb b}genfbj snzmg _bnxx Nfzbctgznlfxpagzzb NN b~bpnbhb -_bnxx Hl&! Ldbtklhmbf!

Cbtegf~. tbznhrab rxbj nf hlforfhznlf snzm gf La~eprx DMXenhtlxhlpb -La~eprx! Engen! IA! RXG. gz g fga egcfn hg%znlf li :00 &

Xzgznxznhga gfga~xnxJgzg gtb b}ptbxxbj gx zmb ebgf XBE& Xzrjbfzx z %zbxz sgxrxbj zl gfga~xb zmb xzgznxznhga xncfn hgfhb li zmb jniibtbfhbxldxbtybj dbzsbbf zmb nfibhzbj gfj hlfztla gxxg~x& Nf zmb znebhlrtxb xzrjnbx! zsl%sg~ GFLYG sgx rxbj! ilaalsbj d~ Zrkb~Ktgebt plxz mlh gfga~xnx& Zmb KgpagfEbnbt ebzmlj sgx rxbjzl hlepgtb xrtynyga hrtybx li zmb xzrjnbj ctlrpx& Jniibtbfhbxsbtb hlfxnjbtbj xzgznxznhgaa~ xncfn hgfz smbf P 1 0&02& Gaa

gfga~xbx sbtb pbtiltebj rxnfc zmb PTNXE 8&0 xlizsgtb-CtgpmPgj! Xgf Jnbcl! HG! RXG.

EgzbtngaxZtgfx%[TrHa-[72UgfbF : .FLU 4+ sgx x~fzmbxnxbj gx jbxhtndbj d~Dlfgybfzrtg bz ga&-400:.& Zmb hmbenhga xztrhzrtb li ztgfx%[TrHa-[72UgfbF : .FLU 4+ nx xmlsf nf Incrtb 7& D - F %dbf ~a%4%

Incrtb 7 -G. Hmbenhga xztrhzrtb li ztgfx %[TrHa-[72UgfbF: .FLU 4+;-D. 8J j hgahragzbj! xztrhzrtb li ztgfx %[TrHa-[72UgfbF: .FLU 4+-m~jtlcbf gzlex gtb lenzzbj.&

FL jlflt zmbtgp~ ilt Hmgcgx jnxbgxb: PEE Crbjbx bz ga



5/13

fnztl%7%nenjg laghbzgenjb. sgx itle Tlhmb! GG gfjpmbf~abpmtnfb itle Xnceg

Tbxrazx

Ztgfx%[TrHa-[72UgfbF : .FLU 4+ mgx als zl}nhnz~ gfj mncm AJ20

D ! smnhm nx zmb jtrc gygnagdab ilt zmb hanfnhga ztbgzebfz li Hmgcgx jnxbgxb! nx rxbj gz mncm jlxbx gfj ilt alfc%zbte

zmbtgp~! snzm xncfn hgfz xnjb biibhzx& Zmb zl}nhnz~ li zmb fbsFL jlflt ztgfx%[TrHa-[72UgfbF : .FLU 4+ sgx jbzbtenfbj gfjhlepgtbj snzm zmgz li D rxnfc DEJE& GG! ztgfx%[TrHa-[72UgfbF : .FLU 4+ gfj D ! gaa gz jlxbx li 7&0! 0&2 gfj0&7 eE! jnj flz ptljrhb nf ynztl h~zlzl}nhnz~ -Incrtb 4.& ZmbAJ 20 li ztgfx%[TrHa-[72UgfbF : .FLU 4+ ilt enhb sgx gpptl}n%

egzba~ 4000 e elakc %7! snzm zmb abzmga jlxb tgfcnfc itle4000 zl 9000 e elakc %7&

Incrtb 4 Ztgfx %[TrHa-[72UgfbF: .FLU 4+ xmlsbj fl nf ynztl zl}nhnz~ nf hrazrtbx li dlfb egttls eghtlpmgcbx& Zmb nf ynztl zl}nhnz~ gxxg~ li dbf fnjg lab -D ; 7&0 eE. lt zmb FL jlflt ztgfx %[TrHa-[72UgfbF: .FLU 4+ -FL jlflt! 0&7! 0&2 gfj 7&0 eE. galfb! nf hlednfgznlf snzmgxhltdnh ghnj -GG; 0&7! 0&2 gfj 7&0 eE.! lt nf hlednfgznlf snzm GG -0&7! 0&2 gfj 7&0 eE. parx D -7&0 eE. nf dlfb egttls%jbtnybjeghtlpmgcbx -DEJE. gizbt g 4:%m nfhrdgznlf& Zsbbf 40 -2&0! 0&2 gfj 0&002". sgx rxbj gx plxnznyb hlfztla ilt hbaa jbgzm& -G. Pbthbfzeghtlpmgcb jbgzm gz jniibtbfz hlfhbfztgznlfx gfj hlednfgznlfx li zmb hleplrfjx zmgz sbtb zbxzbj& -D. Tbptbxbfzgznyb IGHX gfga~xnx palzxli DEJE gizbt ptlpnjnre nljnjb xzgnfnfc& Flzb zmb aghk li jgegcb lf zmb DEJE zgtcbz hbaax d~ ztgfx %[TrHa-[72UgfbF: .FLU 4+ Jgzg tbptbxbfzebgfx XBE gfj gtb tbptbxbfzgznyb li zmtbb nfjbpbfjbfz b}pbtnebfzx& XXH! xnjb%xhgzzbtbj ancmz; PDX! pmlxpmgzb driibtbj xganfb& /Xncfn hgfzjniibtbfhb - P 1 0&02.&




6/13

Fb}z! sb zbxzbj smbzmbt zmb FL jlflt bfmgfhbx zmb nfztg%hbaaragt FL hlfhbfztgznlf! smnhm giibhzx zmb nfztghbaaragtiltex li Z& htr n&Eghtlpmgcbx zmgz sbtb hrazrtbj nf zmb ptbx%bfhb li ztgfx%[TrHa-[72UgfbF : .FLU 4+ gfj 0&7 e E pmbf~abpm%tnfb -tbjrhnfc gcbfz. b}mndnzbj bfmgfhbj nfztghbaaragthlfhbfztgznlfx li FL -Incrtb 8.& Zl ybtni~ ni zmnx biibhz sgx

jrb zl zmb jntbhz ghznygznlf li eghtlpmgcbx d~ ztgfx%[TrHa-[72UgfbF : .FLU 4+ lt d~ nzx dnlalcnhgaa~ tbjrhbj

d~%ptljrhzx! DEJE sbtb hrazrtbj nf zmb ptbxbfhb li zmb FLjlflt! gfj zmb b}ptbxxnlf abybax li zmb hl%xzneragzlt~ ela%bhrabx HJ:0! HJ=0! HJ=9 gfj EMH%NN sbtb gfga~xbj& Zmbgjjnznlf li jtrcx -FL jlflt! GG! gfj D . jnj flz bfmgfhb zmbb}ptbxxnlf li zmb hl%xzneragzlt~ elabhrabx nf eghtlpmgcbx

-Incrtb X7G.& Zmnx gdxbfhb li jntbhz ghznygznlf li eghtlpmgcbxd~ zmb FL jlflt sgx hlf tebj d~ rxnfc ertnfb TGSeghtlpmgcb%ankb hbaax zmgz xzgda~ b}ptbxxbj g FI%k D arhnibtgxbtbpltzbt& Gizbt dbnfc hrazrtbj snzm zmb jtrcx! zmbxb tbpltzbthbaax jnj flz xmls bfmgfhbj arhnibtgxb b}ptbxxnlf-Incrtb X7D.& Zmbxb tbxrazx xmlsbj zmgz zmb bfmgfhbebfz li FL hlfhbfztgznlf nf eghtlpmgcbx jnj flz tbxraz itle g cbf%btganxbj ghznygznlf li eghtlpmgcbx d~ zmb jtrcx! drz tgzmbt gxg tbxraz li zmb tbabgxb li FL d~ ztgfx%[TrHa-[72UgfbF : .FLU 4+&

Ztgfx%[TrHa-[72UgfbF : .FLU 4+ mgx plzbfz nf ynztlzt~pgflhnjga ghznynz~

Gizbt bxzgdanxmnfc zmb xgibz~ li ztgfx%[TrHa-[72UgfbF : .FLU4+

zmtlrcm nzx als nf ynztl zl}nhnz~ gfj snjb zmbtgpbrznh snfjls!sb bygargzbj nzx gdnanz~ zl nfmndnz gaa anib h~hab xzgcbx li Z& htr n&Gf gxxbxxebfz li zmb nf ynztl gfzn%ptlanibtgznyb ghznynz~ gcgnfxzbpnegxznclzbx tbybgabj zmgz D xmlsbj g 700" gfzn%ptlanibtgznyb biibhz gz 7&0 eE& Ztbgzebfz snzm zmb FL jlfltgalfb xmlsbj gf gpptl}negzba~ 7040" gfzn%ptlanibtgznybghznynz~ gcgnfxz zmb bpnegxznclzb ilte li Z& htr n&Gx zmbFL%tbabgxnfc ghznynz~ li zmb FL jlflt jbpbfjx rplf zmbptbxbfhb li tbjrhnfc gcbfzx nf zmb ebjnre! ztbgzebfz snzm ghlednfgznlf li zmb FL jlflt gfj GG xmlsbj 700" ghznynz~gcgnfxz zmb bpnegxznclzb ilte! xnenagt zl zmgz li 7&0 eE D-Incrtb :G.& Nfzbtbxznfca~! ztgfx%[TrHa-[72UgfbF : .FLU 4+ sgxeltb bi hnbfz gz hlfhbfztgznlfx zmgz sbtb 700%ilaj alsbtzmgf zmlxb li D gcgnfxz zt~plegxznclzbx! smnhm gtb zmbZ& htr niltex ptbxbfz nf zmb dallj li ybtzbdtgzb mlxzx-Incrtb :D.& Gz g hlfhbfztgznlf li 7&0 eE! D knaabj 28" li zt~plegxznclzb iltex gizbt 4: m li nfhrdgznlf! smbtbgx zmbztgfx%[TrHa-[72UgfbF : .FLU 4+ parx GG gz 0&7! 0&2 gfj 7&0 eEknaabj 700" li zt~plegxznclzb iltex gizbt = m -Incrtb :D.& GD hlfhbfztgznlf li 70 eE sgx tbwrntbj zl knaa 700" li pgtgxnzbx -jgzg flz xmlsf.& Gx ldxbtybj gcgnfxz bpnegxznclzbiltex! zmb ghznlf li zmb FL jlflt gcgnfxz zt~plegxznclzbiltex gaxl jbpbfjbj lf zmb ptbxbfhb li tbjrhnfc gcbfzx&

Gizbt FL tbabgxb itle ztgfx%[TrHa-[72UgfbF : .FLU 4+! zmb FLnf zmb hlepab} nlf nx tbpaghbj d~ M 4L zl ilte zmb hlepab}nlf ztgfx%[TrHa-[72UgfbF : .M4L +U& Nf ltjbt zl jbzbtenfb ni zmnxnlf! jbylnj li FL! gaxl mgx zt~pgflhnjga ghznynz~! zmb gwrblrxhlepab} sgx nfhrdgzbj snzm zmb zt~plegxznclzb gfj bpnegx%znclzb iltex li Z& htr n& Zmtlrcmlrz zmb tgfcb li hlfhbfztg%znlfx zmgz sbtb rxbj -0&7! 0&2 gfj 7&0 eE.! gpptl}negzba~40" li zmb zt~plegxznclzbx sbtb knaabj! gfj 80" li zmbbpnegxznclzbx jnxpag~bj g tbjrhznlf nf ptlanibtgznlf-Incrtb :H!J.& Zmb FL jlflt nx zmrx ankba~ zl xmls g x~fbt%cnxe dbzsbbf FL tbabgxb gfj zmb frhabrx li zmb ebzgaanhhleplrfj&

Irtzmbteltb! nf hrazrtbj Ybtl hbaax! ztgfx%[TrHa-[72UgfbF : .FLU 4+! nf zmb ptbxbfhb li g tbjrhnfc gcbfz!sgx eltb bi hnbfz zmgf D gcgnfxz zmb nfztghbaaragt gegxznclzbilte -Incrtb :B.& Ybtl hbaax sbtb nfibhzbj snzm Z& htr ngfj

sbtb ztbgzbj snzm jtrcx gizbt pgtgxnzb nfzbtfganxgznlf& Zmb FLjlflt jnj flz xmls g xncfn hgfz biibhz gcgnfxz gegxznclzb

Incrtb 8 Ztgfx %[TrHa-[72UgfbF: .FLU 4+ bfmgfhbx h~zlxlanh FLhlfhbfztgznlf nf eghtlpmgcb hbaax itle enhb& Hrazrtbx li dlfbegttls%jbtnybj eghtlpmgcbx -DEJE.! ztbgzbj lt rfztbgzbj snzmztgfx%[TrHa-[72UgfbF : .FLU 4+ -7&0 eE! ilt 700! 400 gfj 800 x. sbtbptb%nfhrdgzbj nf JGI%4JG -70 e E. ilt 80 enf gz tlle zbepbtgzrtbgfj b}genfbj rfjbt fflrltbxhbfz ancmz& -G. Xncfn hgfz bfmgfhbebfzli zmb JGI%4JG fflrltbxhbfz ctbbf xzgnfnfc 800 x gizbt FL jlflt gjjnznlf galfc snzm 0&7 e E pmbf~abpmtnfb -tbjrhnfc gcbfz.! hle%pgtbj snzm zmb hlfztla hrazrtb -0&7 e E pmbf~abpmtnfb galfb.& Dgtxtbptbxbfz zmb ebgf XBE li yb jniibtbfz xgepabx& /jbflzbx xzgznx%

znhga jniibtbfhb nf zmb fflrltbxhbfhb nfzbfxnz~!P 1

0&007& -D. Xbtngahlfilhga negcbx itle DEJE nf hrazrtb ebjnre -Hlfztla. gfj FLjlflt%ztbgzbj eghtlpmgcbx& Enhtlpmlzlctgpmx tbptbxbfzgznyb li fflrltbxhbfhb nf eghtlpmgcb hbaax sbtb tbhltjbj dbiltb -ebjnregalfb. gfj 700! 400 gfj 800 x gizbt gjjnznlf li zmb hlednfgznlf li 7&0 eE li ztgfx %[TrHa-[72UgfbF: .FLU 4+ gfj 0&7 e E pmbf~abpmtnfb&




7/13

Incrtb : Ztgfx %[TrHa-[72UgfbF: .FLU 4+ xmlsx plzbfz zt~pgflhnjga ghznynz~ nf ynztl& Zmb gfznptlanibtgznyb gfj zt~pgflhnjga ghznynznbx -xmlsf gx". li zmb FL jlflt ztgfx %[TrHa-[72UgfbF: .FLU 4+ -0&7! 0&2 gfj 7&0 eE. lf bpnegxznclzb -G. gfj zt~plegxznclzb -D. iltex li zmb Zt~pgflxleg htr n xztgnf nf hrazrtb ebjng& Pgtgxnzbx sbtb ztbgzbj snzm dbf fnjg lab -D ! 7&0 eE. lt FL jlflt galfb! nf hlednfgznlf snzm gxhltdnh ghnj-GG! 0&7! 0&2 gfj 7&0 eE.! lt nf hlednfgznlf snzm GG parx D & Zmb gfznptlanibtgznyb -H. gfj zt~pgflhnjga -J. ghznynznbx li zmb gwrblrxhleplrfj ztgfx %[TrHa-[72UgfbF: .M4LU+ -0&7! 0&2 gfj 7&0 eE. sbtb gjenfnxzbtbj galfb& Gfznptlanibtgznyb gfj zt~pgflhnjga ghznynznbx li ztgfx %[TrHa-[72UgfbF: .FLU 4+ gfj li zmb gwrblrx hleplrfj ztgfx%[TrHa-[72UgfbF : .M4LU+ lf bpnegxznclzb gfj zt~plegxznclzb iltex li Z&htr n sbtb jbzbtenfbj d~ hlrfznfc yngdab pgtgxnzbx gz =! 74!gfj 4: m plxz%ztbgzebfz& Zmb xgeb hlfhbfztgznlfx jbxhtndbj gdlyb ilt ztgfx %[TrHa-[72UgfbF: .FLU 4+ sbtb gaxl rxbj gcgnfxz gegxznclzb iltex -B.& Hrazrtbx sbtb xzgnfbj d~ Cnbexg j~b& Bghm plnfz nx zmb ebgf XBEgfj nx tbptbxbfzgznyb li zmtbb nfjbpbfjbfz b}pbtnebfzx snzm xnenagt tbxrazx - f 5 70.& Xzgznxznhgaa~ xncfn hgfz jniibtbfhbx itle hlfztla -P 1 0&02.gtb jbflzbj d~ /! (&




8/13

iltex li zmb pgtgxnzb smbf nz sgx gjjbj galfb zl zmbhrazrtb& Gizbt ztbgzebfz snzm 7&0 eE li D lt ztgfx%[TrHa-[72UgfbF : .FLU 4+ parx GG! zmb ptlpltznlf li nfibhzbjhbaax sgx 7: :" gfj 4 0&2"! tbxpbhznyba~! smbtbgx! nfrfztbgzbj hrazrtbx! zmbtb sbtb 8= >" nfibhzbj hbaax& Zgkbf

zlcbzmbt! zmbxb tbxrazx nfjnhgzb zmgz zmbnf ynztl zt~pgflhnjgabiibhz li ztgfx%[TrHa-[72UgfbF : .FLU 4+ nf zmb ptbxbfhb li gtbjrhnfc gcbfz sgx ctbgzbt zmgf zmgz li D &

Zmb FL jlflt xrpptbxxbj zmb pgtgxnzgbeng! eltzganz~ gfj e~lhgtjnznxZmb hlfztla rfztbgzbj gfnegax gfj zmlxb ztbgzbj snzmGG galfb xmlsbj xnenagt pgtgxnzgbengx! snzm zmb abyba li pgtgxnzgbeng pbgknfc lf zmb jg~ > p&n& Zmb pgtgxnzgbeng sgxxrpptbxxbj dbzsbbf zmb xbhlfj gfj ilrtzm jg~x li ztbgzebfznf gaa gfnegax zmgz sbtb ztbgzbj snzm bnzmbt zmb FL jlflt-8&88e elakc %7jg~ %7. galfb lt D -8=2 e elakc %7jg~ %7. galfb&

G hlednfbj ztbgzebfz snzm dlzm jtrcx xrpptbxxbj zmb pgtg%xnzgbeng lf zmb txz jg~ li ztbgzebfz& Gaa hlfztla -rfztbgzbj.gfnegax xmlsbj xncfn hgfza~ mncmbt pgtgxnzgbeng abybax gfjpgzbfz pbtnljx - P 1 0&007. zmgf gfnegax ztbgzbj snzm FLjlflt gfj,lt D -Incrtb 2G.& Nf hlfztgxz zl zmb nf ynztl biibhzx!xnenagt tbxrazx sbtb ldxbtybj nf enhb ztbgzbj snzm zmb FLjlflt bnzmbt galfb lt nf hlednfgznlf snzm GG& Zmnx sgx jrbzl zmb ptbxbfhb li tbjrhnfc gcbfzx nf zmb dallj gfj mlxzznxxrbx& G xrtynyga tgzb li 700" li zmb Z& htr n%nfibhzbj gfjztgfx%[TrHa-[72UgfbF : .FLU 4+ parx D %ztbgzbj gfnegax sgxldxbtybj ilt 9 elfzmx gizbt zmb ztbgzebfz! ilt gaa zmb zmbtg%pbrznh xhmbebx rxbj& Nf hlfztgxz! rfztbgzbj hlfztlax gfjgfnegax ztbgzbj snzm GG galfb xmlsbj g xrtynyga tgzb li 0 gfj70" tbxpbhznyba~ -Incrtb 2D.&

Hgtjngh nffflgeegznlf sgx bygargzbj gz zmb bfj li zmb ztbgz%ebfz -42 jg~x p&n&.& Smbf gjenfnxzbtbj xbpgtgzba~! D gfj zmbFL jlflt sbtb flz gdab zl ghmnbyb iraa habgtgfhb li zmbhgtjngh nffflgeegznlf -Incrtb 2H!J.! gazmlrcm zmbxb ztbgz%ebfzx xmlsbj xncfn hgfza~ alsbt abybax li e~lhgtjnga nffflge%egznlf - P 1 0&02. zmgf hlfztla gfnegax ztbgzbj snzm GG ltrfztbgzbj gfnegax& Nfzbtbxznfca~! smbf gjenfnxzbtbj zlcbzmbt!D gfj ztgfx%[TrHa-[72UgfbF : .FLU 4+ banenfgzbj e~lhgtjnznx nfenhb -Incrtb 2H!J.! smbzmbt lt flz GG sgx gaxl gjjbj& GGsgx rxbj gx tbjrhnfc gcbfz zl gxxnxz FL tbabgxb egnfa~ nf ynztl&

Zsl elfzmx gizbt bghm ztbgzebfz! zmb gfnegax sbtb xbpg%tgzbj nfzl hrtbj lt flz hrtbj ctlrpx! ghhltjnfc zl zmb tbxrazxli zmb pgtgxnzlalcnhga gfj xbtlalcnhga zbxzx& Dlzm zmb hrtbj gfjzmb flz hrtbj gfnegax zmgz mgj dbbf ztbgzbj snzm ztgfx%[TrHa-[72UgfbF : .FLU 4+ gfj,lt D xmlsbj fl hgtjngh nffflge%egznlf lt xncfn hgfza~ jbhtbgxbj hgtjngh nffflgeegznlf!tbxpbhznyba~! smbf hlepgtbj snzm zmlxb gfnegax zmgz sbtbztbgzbj snzm GG - P 1 0&02. -jgzg flz xmlsf.& Zmb ztbgzbj ctlrphlraj flz db hlepgtbj snzm zmb nfibhzbj gfj rfztbgzbjgfnegax! dbhgrxb gaa zmb rfztbgzbj enhb jnbj! gx jnj zmlxbztbgzbj snzm GG! snzm lfa~ g xnfcab xrtynylt nf zmb agzzbt ctlrpgz 7 elfzm gizbt ztbgzebfz& Zmb tbjrhbj e~lhgtjnznx ldxbtybjgz zmb bfj li zmb ztbgzebfz hlttbagzbj snzm zmb pllt ptljrh%znlf li FL gfj h~zlknfbx -NA%70! NIF% c gfj ZFI% g . jbzbhzbj nfzmb xbtg li gaa ztbgzbj gfnegax -Incrtb X4G!D.& Gx ldxbtybj nfzmb hgtjngh nffflgeegzlt~ ptlhbxx 42 jg~x p&n! fnztnzb gfj

nffflgeegzlt~ h~zlknfb ptljrhznlf abybax sbtb mncm nf zmbnfibhzbj gfj rfztbgzbj gfnegax gfj nf zmb enhb ztbgzbj snzm

GG smbf hlepgtbj snzm zmb gfnegax ztbgzbj snzm ztgfx%[TrHa-[72UgfbF : .FLU 4+ gfj,lt D -Incrtb X4G!D.& Zmb pgtgxn%zlalcnhga hrtb sgx hlttbagzbj snzm zmb gdxbfhb li e~lhgtjnznxgfj flteganxgznlf li xbtre h~zlknfb gfj FL ptljrhznlf nfgfnegax zmgz sbtb ztbgzbj snzm g hlednfgznlf li ztgfx%

[TrHa-[72UgfbF : .FLU 4+

gfj D -Incrtb 2 gfj Incrtb X4G!D.&Pgtgxnzlalcnhga hrtb sgx ybtn bj d~ zmtbb nfjbpbfjbfz htnzb%

tng! nfharjnfc mgbelhrazrtb! tbga%zneb PHT gfj zmb ptbxbfhbli xpbhn h NcC gfzn%Z& htr ngfzndljnbx jbzbhzbj d~ BANXG& Nfenhb ztbgzbj snzm GG -ctlrp 7.! D -ctlrp 4.! ztgfx%[TrHa-[72UgfbF : .FLU 4+ -ctlrp 8.! ztgfx%[TrHa-[72UgfbF : .FLU 4+

parx D -ctlrp :.! GG parx ztgfx%[TrHa-[72UgfbF : .FLU 4+ -ctlrp2. gfj GG parx ztgfx%[TrHa-[72UgfbF : .FLU 4+ parx D -ctlrp 9.!zmbpgtgxnzlalcnhgagfjxbtlalcnhga zbxzx sbtb fbcgznyb ilt 0! :0!80! =0! 40 gfj =0" li zmb gfnegax tbxpbhznyba~ -Zgdab 7.&Xbtre abybax li Z& htr n%xpbhn h neerflcaldranf C gfzndljnbxgfj pgtgxnzb JFG abybax nf zmb gfnega ctlrpx ztbgzbj snzm zmbFL jlflt parx D sbtb gdxbfz lt tbegtkgda~ als! gz abybax zmgz

sbtb ybt~ xnenagt zl zmlxb nf zmb rfnfibhzbj hlfztla ctlrp-Incrtb X8.& Xnenagt zl zmb rfztbgzbj hlfztla ctlrp! jbgzmxlhhrttbj gelfc enhb ztbgzbj snzm GG jrtnfc zmb ghrzb pmgxbli zmb nfibhznlf! snzm lfa~ lfb elrxb xrtynynfc zmtlrcm zlzmb hrtb tgzb bygargznlf pbtnlj&

Lybtgaa! zmbxb tbxrazx nfjnhgzb zmgz ztbgzbj drz flz hrtbjgfnegax xznaa mgj tbjrhznlfx nf hgtjngh pgtgxnznxe gfj nfhgtjngh jgegcb! jbelfxztgznfc zmb nepltzgfhb li ztbgzebfz!bybf smbf zmb gfnegax sbtb flz zlzgaa~ hrtbj&

Jnxhrxxnlf gfj hlfharxnlfx

Nf zmnx xzrj~! ztbgzebfz snzm zmb fbs FL jlflt ztgfx%[TrHa-[72UgfbF : .FLU 4+ tbjrhbj pgtgxnznh algj! hgtjngh nffflge%egznlf! gfj gaalsbj 700" xrtynyga nf enhb jrtnfc zmb ghrzbpmgxb li gf b}pbtnebfzga nfibhznlf snzm g mncma~ yntrabfzxztgnf li Z& htr n& Nf gjjnznlf! zmnx jtrc sgx gdab zl nfjrhb gpgtgxnzlalcnhga hrtb nf :0" li zmb ztbgzbj enhb& Eltblybt!ztbgzebfz nf hlednfgznlf snzm D bfmgfhbj zmb tgzb li pgtg%xnzlalcnhga hrtb rp zl =0"&

Hrttbfza~ gygnagdab gfznpgtgxnznh gcbfzx ilt zmb bznlalcnhgaztbgzebfz li Hmgcgx jnxbgxb nfharjb D gfj fnirtznel}& Zmblrzhlebx ldzgnfbj snzm dlzm jtrcx gtb jnybtxb! gfj zmbnt hrtbtgzbx jbpbfj lf zmb xzgcb li zmb jnxbgxb gx sbaa gx lf zmbxbfxnznynz~ li zmb pgtgxnzb xztgnf! smnhm ygtnbx cblctgpmnhgaa~-Inagtjn gfj Dtbfbt! 7>=3; Xlxg Bxzgfn gfj Xbcrtg! 7>>>;Crbjbx bz ga&! 4009.& Jbxpnzb dbnfc dbfb hnga jrtnfc zmb ghrzbxzgcb li nfibhznlf! zmb lrzhlebx li zmbxb gfznpgtgxnznh zmbtg%pnbx jrtnfc hmtlfnh nfibhznlf mgyb flz dbbf x~xzbegznhgaa~bygargzbj& Elxz Hmgcgx jnxbgxb hgxbx gtb jbzbhzbj jrtnfc zmbhmtlfnh pmgxb li zmb jnxbgxb! smbf hgtjnlygxhragt gfj cgx%ztlnfzbxznfga jgegcb eg~ db nttbybtxndab gfj smbf zmb lfa~gygnagdab zmbtgpbrznh lpznlf eg~ db xrtcbt~& Zmrx! zmb jbyba%lpebfz li fbs zmbtgpbrznh gpptlghmbx nx mncma~ nepltzgfzilt zmb ztbgzebfz li Hmgcgx jnxbgxb& Gz zmb elebfz! g era%znhbfztb! tgfjlenxbj jlrdab danfj hanfnhga ztnga nx dbnfc hlf%jrhzbj zl zbxz smbzmbt zmb gjenfnxztgznlf li D zl pgznbfzxsnzm flf%ghrzb iltex li zmb jnxbgxb snaa ptbybfz hmtlfnhhgtjnlygxhragt jgegcb -Egtnf%Fbzl bz ga&! 400=.&

FL pag~x eraznpab nepltzgfz tlabx nf zmb neerfb tbxplfxb!nfharjnfc gfznyntga! gfznenhtldnga! neerflxzneragzlt~!

FL jlflt zmbtgp~ ilt Hmgcgx jnxbgxb= PEE Crbjbx bz ga



9/13

Incrtb 2 Ztbgzebfz snzm ztgfx %[TrHa-[72UgfbF: .FLU 4+ xrpptbxxbx pgtgxnzgbeng! eltzganz~ gfj e~lhgtjnznx li enhb nfibhzbj snzm Z& htr n & Xsnxxenhb sbtb nfibhzbj snzm 7 70 8 dallj zt~plegxznclzbx li Z& htr n xztgnf! ilaalsbj d~ jniibtbfz ztbgzebfz xhmbjrabx? gxhltdnh ghnj -GG;8&88e elakc %7jg~ %7. galfb! dbf fnjg lab -D ; 8=2 e elakc %7jg~ %7. galfb! FL jlflt ztgfx %[TrHa-[72UgfbF: .FLU 4+ -8&88e elakc %7jg~ %7.galfb! FL jlflt -8&88 e elakc %7jg~ %7. parx dbf fnjg lab -8=2 e elakc %7jg~ %7.! FL jlflt -8&88 e elakc %7jg~ %7. nf hlednfgznlf snzmgxhltdnh GG -8&88e elakc %7jg~ %7. gfj zmb FL jlflt -8&88 e elakc %7jg~ %7. nf hlednfgznlf snzm GG -8&88 e elakc %7jg~ %7. gfj D-8=2 e elakc %7jg~ %7.& Ztbgzebfz sgx xzgtzbj lf jg~ 2 p&n gfj sgx cnybf jgna~ lf 40 hlfxbhrznyb jg~x& Zmb hlfztla ctlrp tbhbnybj PDX&Pgtgxnzgbeng -G. gfj xrtynyga -D. sbtb bygargzbj jgna~ lybt g pbtnlj li 90 jg~x plxz%nfibhznlf& Tbptbxbfzgznyb xbhznlfx li hgtjngh znxxrb -H. 42jg~x gizbt nfibhznlf -zmb agxz jg~ li ztbgzebfz.& Ltncnfga egcfn hgznlf li enhtlpmlzlctgpmx! :00& Wrgfzn hgznlf li hbaaragt frhabn pbt 20 e e 4li mbgtz znxxrb -J. li flf%ztbgzbj gfj ztbgzbj gfnegax& Flzb zmb x~fbtcnh biibhz li zmb FL jlflt snzm D nf banenfgznfc e~lhgtjnznx nfZ& htr n %nfibhzbj enhb -Incrtb 2H!J.! tbcgtjabxx li zmb ptbxbfhb lt gdxbfhb li GG& Bghm plnfz nx zmb ebgf XBE gfj nx tbptbxbfzgznyb li zmtbbnfjbpbfjbfz b}pbtnebfzx snzm xnenagt tbxrazx - f 5 70.& Xzgznxznhgaa~ xncfn hgfz jniibtbfhbx itle hlfztla -P 1 0&02. gtb jbflzbj d~ /! (& Ilt

b}pbtnebfzga jbzgnax! tbibt zl zmb abcbfj nf Zgdab 7&

FL jlflt zmbtgp~ ilt Hmgcgx jnxbgxbPEE Crbjbx bz ga >



10/13

neerflxrpptbxxnyb! h~zlzl}nh gfj h~zlptlzbhznyb biibhzx&Zmb rxb li nFLX %, % enhb jbelfxztgzbj zmgz elxz li zmbgdlyb%jbxhtndbj biibhzx sbtb ebjngzbj d~ nFLX%jbtnybj FL-Dlcjgf bz ga&! 4000g!d; Fgzmgf gfj Xmnalm! 4000.& FL!smnhm nx ptljrhbj d~ ghznygzbj eghtlpmgcbx! nx htrhnga zlzmb nfztghbaaragt knaanfc li pgtgxnzbx! nfharjnfc Z& htr n-Egtznfx bz ga&! 4007.& Egf~ ptlzl lg gtb gdab zl nfmndnz FLptljrhznlf! smnhm zmrx gaalsx zmbe zl bygjb zmb neerfbx~xzbe& Z& htr nnfjrhbx gplpzlxnx nf a~epmlh~zbx! gfj tbcr%agznlf li nFLX ebjngzbj d~ hbaahbaa hlfzghz mgx dbbf xbbfnf gplpzlznh a~epmlh~zbx -Itbntb%jb%Aneg bz ga&! 4000.&Rpzgkb li gplpzlznh hbaax jtnybx zmb ctlszm li Z& htr nsnzmnfeghtlpmgcbx& Zmb rpzgkb li gplpzlznh! drz flz fbhtlznh!a~epmlh~zbx d~ eghtlpmgcbx zmtlrcm dtlfbhznf tbhbpzltxgfj HJ89 abgjx zl zmb jlsf%tbcragzbj b}ptbxxnlf li nFLXgfj! zmrx! xmnizx A%gtcnfnfb ebzgdlanxe zlsgtjx zmb gtcnfgxbpgzmsg~& Nf zrtf! zmbtb nx nfhtbgxbj ptljrhznlf li ltfnzmnfbgfj prztbxhnfb! smnhm gtb kflsf ctlszm ighzltx ilt Z& htr n&Zmbxb biibhzx tbxraz itle zmb nfjrhznlf li bfjlcbflrx ZCI% dgfj neerfb x~xzbe bygxnlf -Itbntb%jb%Aneg bz ga&! 4000.& GxFL ptljrhbj snzmnf pmgclh~zbx nx htrhnga zl pgtgxnzb knaanfc!zmbtgpbrznh gpptlghmbx zmgz rxb FL%tbabgxnfc hleplrfjxhlraj neptlyb zmb ptlzbhznyb neerfb tbxplfxb gfj gtb zmrxptlenxnfc gcbfzx ilt zmb ztbgzebfz li zmnx nfztghbaaragtpgzmlcbf&

Nf ighz! zmb ztbgzebfz li Z& htr n%nfibhzbj! neerflxrp%ptbxxbj enhb snzm D cbfbtgzbx alsbt xrtynyga gfj hrtb tgzbxzmgf zmb xgeb ztbgzebfz nf neerflhlepbzbfz gfnegax!smnhm nfjnhgzbx zmgz zmb ptlzbhznyb biibhzx li D ! pgtznhragta~zmb ptlhbxxbx li eghtlpmgcb ghznygznlf! FL ptljrhznlf gfjpgtgxnzb jbxztrhznlf! gtb jbpbfjbfz lf zmb nfzbctnz~ li zmbneerfb x~xzbe -Xnayg bz ga&! 7>>2; Elanfg bz ga&! 4000.&Tbhbfza~! lrt ctlrp jbelfxztgzbj zmgz FL jlfltx gjenfnx%zbtbj gz als hlfhbfztgznlfx gtb hgpgdab li knaanfc Z& htr n-Xnaygbz ga&! 4003.& Zmb tgzb li pgtgxnzlalcnhga hrtb ilt zmbxb hle%plrfjx mgx flz dbbf jbzbtenfbj& Eltblybt! zmb FL jlfltrxbj nf zmb ptbxbfz xzrj~ xmlsbj dbzzbt biibhzx gcgnfxz Z& htr n

zmgf zmlxb ptbynlrxa~ zbxzbj d~ lrt ctlrp! smnhm nx ankba~ jrbzl zmb alfcbt pbtnlj li FL tbabgxb -Dlfgybfzrtg bz ga&! 400:.

gfj x~fbtcnxznh ghznynz~ snzm zmb gwrblrx nlf iltebj itleztgfx%[TrHa-[72UgfbF : .FLU 4+&

Sb jbelfxztgzbj zmgz ztgfx%[TrHa-[72UgfbF : .FLU 4+ jnj flzxmls nf ynztl zl}nhnz~ zl dlfb egttls eghtlpmgcbx& Nf gjjn%znlf! zmb h~zlxlanh FL hlfhbfztgznlf snzmnf eghtlpmgcbx nfhrazrtb sgx tbegtkgda~ bfmgfhbj gizbt zmb gjjnznlf li ztgfx%[TrHa-[72UgfbF : .FLU 4+ galfc snzm zmb tbjrhnfc gcbfz pmb%f~abpmtnfb zl zmb hrazrtb ebjnre& Zmb zmbtgpbrznh jlxb rxbjnf ynyl sgx sbaa dbals nzx AJ 20 -8&88e elakc %7 yx& 40009000 e elakc %7.& Bybf smbf gjenfnxzbtbj gz alsbt hlfhbfztg%znlfx! ztgfx%[TrHa-[72UgfbF : .FLU 4+ sgx eltb bi hnbfz zmgf Dnf knaanfc zmb bpnegxznclzb! zt~plegxznclzb gfj gegxznclzbiltex li Z& htr n& Gazmlrcmztgfx%[TrHa-[72UgfbF : .FLU 4+ sgxybt~ biibhznyb nf ynztl! nz lfa~ cbfbtgzbj g 80" pgtgxnzlalcnhgahrtb tgzb nf ynyl smbf gjenfnxzbtbj galfb& Zmb hrtb tgzb li gjtrc hlttbagzbx snzm nzx pmgteghlknfbznh hmgtghzbtnxznhx! xrhmgx dnlgygnagdnanz~! itbwrbfh~! pgzmsg~ li gjenfnxztgznlf gfjlzmbt ighzltx& Zmnx pgtznhragt FL jlflt jtrc nfhtbgxbx zmbzneb lybt smnhm FL nx tbabgxbj! smnhm eg~ mgyb gf biibhz lfnzx hrtb tgzb& Bygargznlf li zmbxb ighzltx nf zmb ertnfb eljbasnaa hlfxznzrzb zmb fb}z xzbpx nf lrt tbxbgthm& Gx zmbFL%tbabgxnfc ghznynz~ li ztgfx%[TrHa-[72UgfbF : .FLU 4+ agxzx ilt4 m -Dlfgybfzrtg bz ga&! 400:.! g xhmbjrab li cnynfc ztgfx%[TrHa-[72UgfbF : .FLU 4+ zsl lt zmtbb znebx g jg~ slraj ptld%gda~ neptlyb nzx pmgteghlj~fgenh ptlpbtznbx& Dgxbj lf zmb

fjnfcx tbpltzbj nf zmnx pgpbt! irzrtb xzrjnbx hgf db hlf%jrhzbj zl jbzbtenfb ni gfj mls zmb FL tbabgxb pbtnlj hgf dbb}zbfjbj&

Sb ldxbtybj 700" li xrtynyga nf enhb ztbgzbj snzm8&88e elakc %7jg~ %7 li ztgfx%[TrHa-[72UgfbF : .FLU 4+! bnzmbtgalfb lt nf hlednfgznlf snzm 8=2 e elakc %7jg~ %7 li D ! smnabgaa zmb nfibhzbj gfj rfztbgzbj gfnegax jnbj& Zmb FL jlfltxzbxzbj gcgnfxz Z& htr n! mlsbybt! gtb flz dnlbwrnygabfz! xnfhbzmb xrtynyga tgzbx li enhb ztbgzbj snzm Tr-FL.neF ltTr-FL.nxf gz zmb xgeb elagt jlxb sbtb :0 gfj 90" tbxpbh%znyba~ -Xnaygbz ga&! 4003.& Zmbxb tbxrazx jbelfxztgzb zmgz zmbztgfx%[TrHa-[72UgfbF : .FLU 4+ gfj lzmbt FL jlfltx zmgz mgj

dbbf ptbynlrxa~ zbxzbj gtb eltb plzbfz gfj xgibt zmgf D & Lrttbxrazx gtb ptlenxnfc! cnybf zmgz zmb FL jlflt ztgfx%

Zgdab 7 Zmb FL jlflt ztgfx %[TrHa-[72UgfbF: .FLU 4+ ptljrhbj pgtgxnzlalcnhga hrtb li b}pbtnebfzga Hmgcgx jnxbgxb

Zmbtgpbrznh xhmbjrab g Plxnznyb tbxrazx,zbxz d F l li plxnznyb zbxzx plxz%ztbgzebfz,zlzga -".

Hrtb tgzb -".

F l li plxnznyb BANXG,zlzga

F l li plxnznyb mgbelhrazrtb,zlzga

F l li plxnznyb tbga%zneb PHT,zlzga

Gxhltdnh ghnjh -GG. 7 7 7 7,7 -700. 0Dbf fnjg lab -D . 9 2 9 9,70 -90. :0FL jlflt 3 9 3 3,70 -30. 80FL jlflt + D 4 7 4 4,70 -40. =0FL jlflt + GG = : = =,70 -=0. 40FL jlflt + GG+ D 4 4 4 4,70 -40. =0

gZmb biibhzx li zmb FL jlflt! ztgfx%[TrHa-[72UgfbF : .FLU 4+! cnybf galfb gfj,lt? GG! D gx sbaa gx zmb FL jlflt parx gxhltdnh ghnj parx dbf fnjg lab lf enhbnfibhzbj snzm Z& htr n ^ xztgnf lf ebgxrtbx li hrtb gtb xmlsf&Xsnxx ibegab enhb! 4=80 c! sbtb nfibhzbj snzm 7 70 8 dallj zt~plegxznclzbx li Z& htr n ^ xztgnf& Ztbgzebfz xzgtzbj gizbt jbzbhznlf li pgzbfz pgtgxnzgbeng! lf jg~2 p&n& cnybf jgna~ lybt g pbtnlj li 40 jg~x& Zmb FL jlflt ztgfx%[TrHa-[72UgfbF : .FLU 4+! gfj GG sbtb nfobhzbj n&p& gz 8&88e elakc %7jg~ %7& D sgx gjenfnxzbtbjltgaa~ gz 8=2 e elakc %7& Zmb nfibhzbj hlfztla ctlrp tbhbnybj PDX& Jgzg gtb b}ptbxxbj gx zmb ebgf XBE gfj gtb tbptbxbfzgznyb li zmtbb nfjbpbfjbfz b}pbtnebfzxsnzm xnenagt tbxrazx!f 5 70& PDX! pmlxpmgzb driibtbj xganfb&dTbxrazx xmlsf gtb zmb fredbt li plxnznyb BANXG! mgbelhrazrtb gfj tbga zneb PHT zbxzx& Zbf enhb sbtb rxbj ilt bghm ztbgzebfz ctlrp gfj ilt zmb flz nfibhzbjgfj Z& htr n%nfibhzbj hlfztlax&h

Lfa~ lfb gfnega tbegnfbj ganyb rfzna zmb pbtnlj li zmb hrtb tgzb bygargznlf nf zmb hlfztla ctlrp& Fl xrtynygax sbtb ldxbtybj nf zmb PDX! rfztbgzbj hlfztla ctlrp&




11/13

[TrHa-[72UgfbF : .FLU 4+ jnxpag~x hmgtghzbtnxznhx zmgz hlepa~snzm zmb bxxbfznga htnzbtng ilt gfznpgtgxnznh jtrcx xpbhn bj d~zmb SML gfj lzmbt ltcgfnxgznlfx trffnfc hlfztla ptl%ctgeebx nf giibhzbj hlrfztnbx&

Zmb hgtjngh nffflgeegzlt~ ptlhbxx sgx jbhtbgxbj gz zmb bfj

li zmb ztbgzebfz snzm ztgfx%[TrHa-[72UgfbF : .FLU 4+

! snzm D ltsnzm zmbnt hlednfgznlf -49 j&p&n&.& G abxx nfzbfxb tbjrhznlf li e~lhgtjnznx nx ldxbtybj snzm lzmbt FL jlfltx gfj D-Gfjtgjb bz ga&! 7>>7; Xbcrtg bz ga&! 7>>:; Xnayg bz ga&! 4003.&Mlsbybt! zmb hlednfgznlf li FL jlflt gfj D tbxrazbj nfzmb gdxbfhb li e~lhgtjnznx d~ zmb bfj li zmb ztbgzebfz& Eltb%lybt! gfnegax zmgz sbtb ztbgzbj drz flz hlfxnjbtbj zl db hrtbjxmlsbj g tbjrhbj abyba li hgtjngh nffflgeegznlf smbf hle%pgtbj snzm zmb hlfztla -gfnegax ztbgzbj snzm GG galfb.& Zmbxbgfnegax gaxl xmlsbj jbhtbgxbj pgtgxnznxe& Gx zmb ptbxbfhb li pgtgxnzbx nx dbanbybj zl pag~ gf nepltzgfz tlab nf hgrxnfchgtjngh abxnlfx! xpbhn h jtrc%hlednfgznlf zmbtgpnbx encmztbjrhb zmb e~lhgtjnga jgegcb gfj eltdnjnz~ jrtnfc zmb

ghrzb gfj hmtlfnh pmgxbx li zmb jnxbgxb nf mregf dbnfcx-Hlrtg bz ga&! 7>>3.& Jgzg itle zmb anzbtgzrtb gaxl nfjnhgzb zmbtbybtxndnanz~ li hgtjngh dtlxnx nf enhb hmtlfnhgaa~ nfibhzbjsnzm Z& htr ngfj rfjbtclnfc xpbhn h hmbelzmbtgp~ -Gfjtgjbbz ga&! 7>>7.&

Fbs jtrcx ilt ztbgznfc Hmgcgx jnxbgxb xmlraj db gdab zlneptlyb zmb wrganz~ li anib ilt zmlxb nfibhzbj! zmtlrcm g tbjrh%znlf li zmb hmtlfnh eltdnjnz~! zmb xrdxbwrbfz b}pbfjnzrtb d~clybtfebfz mbgazm x~xzbex gfj bgta~ tbzntbebfz nf jbybalp%nfc hlrfztnbx& Nf hlfharxnlf! lrt tbxrazx nfjnhgzb zmgzztgfx%[TrHa-[72UgfbF : .FLU 4+ mgx dlzm nf ynztl gfj nf ynyl zt~%pgflhnjga ghznynz~ gfj nx hgpgdab li nfjrhnfc g tgjnhga pgtg%xnzlalcnhga hrtb nf g elrxb eljba li ghrzb nfibhznlf&Irtzmbteltb! zmnx hleplrfj hgf db rxbj gz mncm jlxbx gfjtbptbxbfzx g plzbfzngaa~ rxbira hgfjnjgzb ilt zmb ztbgzebfz li Hmgcgx jnxbgxb nf mregf dbnfcx&

Ghkflsabjcbebfzx

Sb zmgfk Htnxzngfb Egtng Enagfb n ilt mbt b}hbaabfz zbhmfnhgagxxnxzgfhb& Zmnx ptlobhz tbhbnybj xrppltz itle Irfjgl jbGepgtl g Pbxwrnxg jl Bxzgjl jb Xl Pgral -IGPBXP 4003,28>:0%0.! Hlfxbaml Fghnlfga jb Jbxbfylaynebfzl Hnbfz hlb Zbhflacnhl -HFPw :70:93,4009%2. gfj g Tbxbgthm ibaals%xmnp itle Hlltjbfgl jb Gpbtibnlgebfzl jb Pbxxxlga jbFyba Xrpbtnlt -HGPBX.&

Tbibtbfhbx

Gandbtzn OH! Eghmgjl IX! Xlrzl OZ! Hgepgfbaan GP! Zbn}bntg EE!Cg nfbaan TZ bz ga&-7>>>.& dbzg%Hmbelknfbx bfmgfhb pgtgxnzbrpzgkb gfj ptlelzb fnztnh l}njb%jbpbfjbfz enhtldnlxzgznh ghznynz~nf ertnfb nffflgeegzlt~ eghtlpmgcbx nfibhzbj snzm Zt~pgflxleghtr n&Nfibhz Neerf 93 ->.? :=7>:=49&

Gandbtzn OH! Xlrzl OZ! Egtnfl GP! Agffbx%Ynbntg O! Zbn}bntg EE! Igtdbt Obz ga&-4007.& Eljragznlf li hmbelknfb ptljrhznlf gfj nffflge%egzlt~ tbxplfxbx nf nfzbtibtlf%cgeeg% gfj zrelt fbhtlxnx ighzlt%T7%jb hnbfz enhb jrtnfc Zt~pgflxleg htr n nfibhznlf& Ge O Pgzmla72= -:.? 7:887::0&

Gazhagx O! Xnfgctg G! Jnhzgt E! Arfg H! Ybtlf EZ! Jb Tnxxnl GE bz ga&-4002.& Hmgcgx jnxbgxb nf dlfb egttls ztgfxpagfzgznlf? gf

gpptlghm zl ptbbepznyb zmbtgp~& Dlfb Egttls Ztgfxpagfz 89 -4.?74874>&

Gfjtgjb XC! Xzlhkbt%Crbttbz X! Pnebfzba GX! Ctnegrj OG -7>>7.&Tbybtxndnanz~ li hgtjngh dtlxnx nf enhb hmtlfnhgaa~ nfibhzbj snzmZt~pgflxleg htr n! rfjbt xpbhn h hmbelzmbtgp~& Ebe Nfxz LxsgajlHtr =9 -4.? 7=3400&

Dlcjgf H -4007.& Fnztnh l}njb gfj zmb neerfb tbxplfxb& Fgz Neerfla4 -70.? >03>79&

Dlcjgf H! Tlaanfcmlii E! Jnbibfdghm G -4000g.& Tbghznyb l}~cbf gfjtbghznyb fnztlcbf nfzbtebjngzbx nf nffgzb gfj xpbhn h neerfnz~&Hrtt Lpnf Neerfla 74 -7.? 9:39&

Dlcjgf H! Tlaanfcmlii E! Jnbibfdghm G -4000d.& Zmb tlab li fnztnhl}njb nf nffgzb neerfnz~& Neerfla Tby 738 ? 7349&

Dlfgybfzrtg J! jb XLI! Zlcfnlal Y! Zbjbxhl GH! jg Xnayg TX!Dbfjmghk AE -400:.& G eghtlh~hanh fnztlx~a trzmbfnre hlepab} nxg FL jlflt zmgz nfjrhbx tgz gltzg tbag}gznlf& Fnztnh L}njb 70 -4.?=8>7&

Dtbfbt _ -7>94g.& [Ldxbtygznlfx lf neerfnz~ zl xrpbtnfibhznlfx nfenhb b}pbtnebfzgaa~ nflhragzbj snzm Zt~pgflxleg htr n gfjxrdobhzbj zl ztbgzebfz&U& Tby Nfxz Ebj Ztlp Xgl Pgral : ? 77>748&

Dtbfbt _ -7>94d.& Zmbtgpbrznh ghznynz~ gfj htnzbtnlf li hrtb lf enhbb}pbtnebfzgaa~ nfibhzbj snzm Zt~pgflxleg htr n& Tby Nfxz Ebj ZtlpXgl Pgral : ? 8=>8>9&

Hgajgx NX! Zgaygfn G! Hgajgx X! Hgtfbntl HE! jb Agfg E! jg EgzzgCrbjbx PE bz ga&-400=.& Dbf fnjg lab zmbtgp~ jrtnfc ghrzb pmgxbli Hmgcgx jnxbgxb tbjrhbx pgtgxnzb algj drz jlbx flz ptbybfzhmtlfnh hgtjngh abxnlfx& Pgtgxnzla Tbx708 -4.? :78:47&

Hgfhgjl OT -4004.& Alfc zbte bygargznlf li bznlalcnhga ztbgzebfz li hmgcgx jnxbgxb snzm dbf fnjg lab& Tby Nfxz Ebj Ztlp Xgl Pgral :: -7.?4>83&

Hbagjg G! Ctg~ PS! Tnfjbtkfbhmz B! Xhmtbndbt TJ -7>=:.& Bynjbfhb iltg cgeeg%nfzbtibtlf tbhbpzlt zmgz tbcragzbx eghtlpmgcb zreltn%hnjga ghznynz~&O B}p Ebj 790 -7.? 223:&

Hlrtg OT! jb Gdtbr AA! Snaahl} MP! Pbzgfg S -7>>3.& [Hlepgtgznybhlfztlaabj xzrj~ lf zmb rxb li dbf fnjg lab! fnirtznel} gfjpaghbdl! nf zmb hmtlfnh ilte li Hmgcgx jnxbgxb! nf g baj gtbg snzmnfzbttrpzbj ztgfxenxxnlf& N& Ptbanenfgt~ bygargznlfU& Tby Xlh Dtgx Ebj Ztlp 80 -4.? 78>7::&

Jlhgepl T -7>>0.& Xbfxnznynz~ li pgtgxnzbx zl itbb tgjnhga jgegcb d~gfznpgtgxnznh jtrcx& Hmbe Dnla Nfzbtghz 38 -7.? 743&

Igddtl Jb Xrgxfgdgt J! Gtngx B! Xztbncbt E! Pnghbf g E! Nfcgtgel E!Jba Dgthl E bz ga&-4000.& Bylarznyb dbmgynlt zlsgtjx hgtjnle~lpg%zm~ li ztbgzbj -fnirtznel} lt dbf fnjg lab. gfj rfztbgzbj hmtlfnhhmgcgxnh pgznbfzx&Tby Nfxz Ebj Ztlp Xgl Pgral :4 -4.? >>70>&

Inagtjn AX! Dtbfbt _ -7>=3.& Xrxhbpzndnanz~ gfj fgzrtga tbxnxzgfhb li Zt~pgflxleg htr n xztgnfx zl jtrcx rxbj hanfnhgaa~ nf Hmgcgxjnxbgxb&Ztgfx T Xlh Ztlp Ebj M~c =7 -2.? 32232>&

Itbntb%jb%Aneg HC! Fgxhnebfzl JL! Xlgtbx ED! Dl g PZ! Hgxztl%Igtng%Fbzl MH! jb Ebaal IC bz ga&-4000.& Rpzgkb li gplpzlznh hbaax

jtnybx zmb ctlszm li g pgzmlcbfnh zt~pgflxleb nf eghtlpmgcbx&Fgzrtb :08 -9399.? 7>>408&Cgaygl AE! Frfbx TE! Hgfhgjl OT! Dtbfbt _! Ktbzzan GR -7>>8.& A~znh

gfzndlj~ znztb gx g ebgfx li gxxbxxnfc hrtb gizbt ztbgzebfz li Hmgcgxjnxbgxb? g 70 ~bgtx ilaals%rp xzrj~& Ztgfx T Xlh Ztlp Ebj M~c =3 -4.?440448&

Ctbbf AH! Zgffbfdgre XT! Clajegf P -7>=7.& Fnztgzb x~fzmbxnx nfzmb cbteitbb gfj hlfybfznlfga tgz& Xhnbfhb474 -::>0.? 292=&

Crbjbx PE! Ybalxl YE! Hgangtn EY! Hgtfbntl HE! Xlr g XE! jb AgfgE bz ga&-4003.& Zt~pgflxleg htr n mncm nfibhznynz~ nf ynztl nxtbagzbj zl hgtjngh abxnlfx jrtnfc alfc%zbte nfibhznlf nf Dbgcab jlcx& Ebe Nfxz Lxsgajl Htr 704 -4.? 7:77:3&

Crbjbx PEE! Inbzzl OAT! Agfg E! Dgmng EZ -4009.& Gjygfhbx nfHmgcgx jnxbgxb hmbelzmbtgp~ gfzn%nfibhznyb gcbfzx nf ebjnhnfga&Hmbenxzt~ 2 -4.? 77&

Agrtng%Pntbx A! Dtgcg EX! Yb}bfgz GH! Fnz F! Xnelbx%Dgtdlxg G!Znflhl JA bz ga&-4000.& Ptlctbxxnyb hmtlfnh Hmgcgx mbgtz jnxbgxb




12/13

zbf ~bgtx gizbt ztbgzebfz snzm gfzn%Zt~pgflxleg htr n fnztljbtnyg%znybx&Ge O Ztlp Ebj M~c 98 -8:.? 77777=&

Eghmgjl IX! Egtznfx CG! Gandbtzn OH! Ebxztnfbt IA! Hrfmg IW! Xnayg OX-4000.& Zt~pgflxleg htr n%nfibhzbj hgtjnle~lh~zbx ptljrhbhmbelknfbx gfj h~zlknfbx zmgz ztnccbt plzbfz fnztnh l}njb%jbpbfjbfz zt~pgflhnjga ghznynz~& Hnthragznlf 704 -4:.? 8008800=&

Egtnf%Fbzl OG! Tgxxn G Ot! Eltnaal HG! Gyb re G! Hlfflaa~ XO! Xlxg%Bxzgfn Xbz ga&-400=.& Tgznlfgab gfj jbxncf li g tgfjlen bj paghbdl%hlfztlaabj ztnga gxxbxxnfc zmb biibhzx li bznlalcnh ztbgzebfz nfHmgcgx hgtjnle~lpgzm~? zmb DBF fnjg lab Bygargznlf Ilt Nfzbt%trpznfc Zt~pgflxlengxnx -DBFBINZ.& Ge Mbgtz O 729 -7.? 83:8&

Egtznfx CG! Pbzklyg XD! Eghmgjl IX! Knzxnx TF! Sbnxx AE! Snzzfbt Ebz ga&-4007.& Igx%IgxA nfzbtghznlf eljragzbx fnztnh l}njb ptljrhznlfnf Zt~pgflxleg htr n%nfibhzbj enhb& Neerflalc~ 708 -7.? 74474>&

Enhmgnalsxk~ Y! Ertzg XE! Hgtygaml%Lanybntg A! Pbtbntg EB! IbttbntgAT! Dtbfbt _ bz ga&-7>>=.& Nfzbtabrknf%74 bfmgfhbx nf ynyl pgtgxnzn%hnjga biibhz li dbf fnjg lab jrtnfc ghrzb b}pbtnebfzga nfibhznlfsnzm g fgzrtgaa~ jtrc%tbxnxzgfz xztgnf li Zt~pgflxleg htr n& Gfznen%htld Gcbfzx Hmbelzmbt :4 -70.? 42:>4229&

Elanfg O! Egtznfx%Inaml L! Dtbfbt _! Tlegfmg GO! Albdbfdbtc J!Rtdnfg OG -4000.& Ghznynznbx li zmb ztng lab jbtnygznyb XHM 292>4-plxghlfg lab. gcgnfxz jtrc%tbxnxzgfz xztgnfx li zmb ptlzl lgf pgtg%xnzb Zt~pgflxleg -Xhmn lzt~pgfre. htr n nf neerflhlepbzbfzgfj neerflxrpptbxxbj ertnfb mlxzx& Gfznenhtld Gcbfzx Hmbelzmbt :: -7.? 720722&

Fgzmgf H! Xmnalm ER -4000.& Tbghznyb l}~cbf gfj fnztlcbf nfzbteb%jngzbx nf zmb tbagznlfxmnp dbzsbbf egeegangf mlxzx gfj enhtldngapgzmlcbfx& Ptlh Fgza Ghgj Xhn RXG>3 -79.? ==:7==:=&

Tgxxn G! Gegzl Fbzl Y! jb Xnwrbntg GI! Ibttnlaan Inaml I! Gegzl YX!Tgxxn Orfnlt G -7>>>.& [Ptlzbhznyb biibhz li dbf fnjg lab gcgnfxzpgtgxnzb tbghznygznlf nf pgznbfzx hmtlfnhgaa~ nfibhzbj snzm Zt~pgfl%xleg htr n gfj ztbgzbj snzm hltznhlnjx ilt gxxlhngzbj jnxbgxbxU& Tby Xlh Dtgx Ebj Ztlp 84 -2.? :32:=4&

Tljtncrbx CO! Arfgtjn HF! Aneg TC! Xgfzlx H]! Agrtnfjl IT! jg XnaygTXbz ga&-400=.& Ynzgenf H neptlybx zmb biibhz li g fbs fnztnh l}njbjlflt lf zmb ygxhragt xellzm erxhab itle tbfga m~pbtzbfxnyb tgzx&Fnztnh L}njb 7= -8.? 7397=8&

Trxxlegfjl C! jb Zlegxxlfb EE! jb Crnaabf N! Ghlxzg F! Ybtg F!Gaentlf E bz ga&-7>>=.& Ztbgzebfz li hlfcbfnzga Hmgcgx jnxbgxbjngcflxbj gfj ilaalsbj rp d~ zmb pla~ebtgxb hmgnf tbghznlf& Ge O Ztlp Ebj M~c 2> -8.? :=3:>7&

Xhmerfnx CG -4003.& Bpnjbenlalc~ li Hmgcgx jnxbgxb nf flf%bfjbenhhlrfztnbx? zmb tlab li nfzbtfgznlfga enctgznlf& Ebe Nfxz LxsgajlHtr 704 -Xrppa& 7.? 32=2&

Xbcrtg EO! Cbflybxb LE! Xbcrtg B! Xgf LP! Xnhg TB -7>>:.& Hbfztgaelzlt hlfjrhznlf nf mregf hmtlfnh Hmgcgx jnxbgxb& Gtw Fbrtlp%xnwrngzt 24 -7.? 4>87&

Xnayg OO! Lxgkgdb GA! Pgygfbaan ST! Xnayg OX! Itgfhl JS -4003.& Nf ynztlgfj nf ynyl gfznptlanibtgznyb gfj zt~pgflhnjga ghznynznbx li trzmb%

fnre FL jlfltx& Dt O Pmgteghla724

-7.? 774747&Xnayg OX! Ybxpg CF! Hgtjlxl EG! Gandbtzn OH! Hrfmg IW -7>>2.& Zreltfbhtlxnx ighzlt gapmg ebjngzbx tbxnxzgfhb zl Zt~pgflxleg htr nnfibhznlf nf enhb d~ nfjrhnfc fnztnh l}njb ptljrhznlf nf nfibhzbjcgeeg nfzbtibtlf%ghznygzbj eghtlpmgcbx& Nfibhz Neerf 98 -74.?:=94:=93&

Xnayg AMP! Frxxbf sbnc Y -7>28.& Xldtb reg hbpg jb Zt~pgflxleghtr n gazgebfzb yntrabfzg pgtg l hgerfjlfcl dtgfhl& Ilang Hanf Dnla40 ? 7>7408&

Xlxg Bxzgfn X! Xbcrtg BA -7>>>.& Ztbgzebfz li Zt~pgflxleg htr nnfibhznlf nf zmb rfjbzbtenfbj pmgxb& B}pbtnbfhb gfj hrttbfzcrnjbanfbx li ztbgzebfz nf Gtcbfznfg& Ebe Nfxz Lxsgajl Htr >:-Xrppa& 7.? 898892&

Xlxg Bxzgfn X! Xbcrtg BA! Trn GE! Ybag wrb B! Plthba DE! ^geplznx H-7>>=.& Bi hgh~ li hmbelzmbtgp~ snzm dbf fnjg lab nf hmnajtbf nf

zmb nfjbzbtenfgzb pmgxb li Hmgcgx jnxbgxb& Ge O Ztlp Ebj M~c 2>

-:.? 24924>&

Rtdnfg OG -7>>>.& Pgtgxnzlalcnhga hrtb li Hmgcgx jnxbgxb? nx nz plxxndab822&

Ynlzzn T! Yncangfl H! Gtebfzn M! Xbcrtg B -7>>:.& Ztbgzebfz li hmtlfnhHmgcgx jnxbgxb snzm dbf fnjg lab? hanfnhga gfj xbtlalcnh bylarznlfli pgznbfzx snzm alfc%zbte ilaals%rp& Ge Mbgtz O 743 -7.? 727794&

Ynlzzn T! Yncangfl H! Alhlhl D! Dbtzlhhmn C! Pbzzn E! Gaygtb EC bz ga&-4009.& Alfc%zbte hgtjngh lrzhlebx li ztbgznfc hmtlfnh Hmgcgxjnxbgxb snzm dbf fnjg lab ybtxrx fl ztbgzebfz? g flftgfjlen bjztnga&Gff Nfzbtf Ebj 7:: -70.? 34:38:&

SML -4002.& Xbybfzbbfzm Ptlctgeeb Tbpltz li zmb RFNHBI,RFJP,Sltaj -Ptlctbxx 4008400:. & Sltaj Mbgazm Ltcgfn gznlf? Cbfbyg! pp&8788& Xpbhnga ptlctgeeb ilt tbxbgthm gfj ztgnfnfc nf ztlpnhgajnxbgxb&

Xrppltznfc nfiltegznlf

Gjjnznlfga Xrppltznfc Nfiltegznlf eg~ db ilrfj nf zmb

lfanfb ybtxnlf li zmnx gtznhab?Incrtb X7 Ztgfx%[TrHa-[72UgfbF : .FLU 4+ jnj flz bfmgfhb zmbb}ptbxxnlf li hl%xzneragzlt~ elabhrabx gfj jnj flz ghznygzbeghtlpmgcbx& Nf ynztlbiibhz li jniibtbfz jtrc xhmbjrabx lf zmbb}ptbxxnlf li HJ:0! HJ=0 gfj HJ=9 hl%xzneragzlt~ gfjEMH%NN elabhrabx nf dallj dlfb egttls%jbtnybj eghtlpm%gcbx&7 Jtrc ztbgzebfzx hlttbxplfjnfc zl bghm xbz li dgtxxzgfjnfc ilt g hl%xzneragzlt~ lt EMH%NN elabhrab nf zmb mnx%zlctge? ebjnre fl jtrc! 7 e c,eA APX! 7&0 eE ztgfx %[TrHa-[72UgfbF : .FLU 4+ parx 7&0 eE gxhltdnh ghnj! 0&2 eEgxhltdnh ghnj! 0&2 eE ztgfx%[TrHa-[72UgfbF : .FLU 4+! 7&0 eEztgfx %[TrHa-[72UgfbF: .FLU 4+ parx 7&0 eE dbf fnjg lab!0&2 eE ztgfx%[TrHa-[72UgfbF : .FLU 4+ parx 0&2 eE gxhltdnh

ghnj parx 0&2 eE dbf fnjg lab& APX sgx rxbj gx g plxnznybhlfztla ilt eghtlpmgcb ghznygznlf& Eghtlpmgcb hrazrtbx sbtbegnfzgnfbj ilt 4: m rfjbt nfhrdgznlf hlfjnznlfx ilaalsnfczmb b}ptbxxnlf gfga~xnx li zmb hl%xzneragzlt~ gfj EMH%NNelabhrabx d~ fflls h~zlebzt~ -G.& Zmb ertnfb eghtlpmgcb%ankb hbaa anfb TGS 49:&3 Arh! dbgtnfc zmb arhnibtgxb ybhzltnfxbtzbj nf zmb FI%kD ptlelzbt! sgx ztbgzbj snzm zmb xgebzmbtgpbrznh xhmbjrab gx gdlyb rfjbt nfhrdgznlf hlfjnznlfxilt 4: m! ptnlt zl zmb gxxbxxebfz li arhnibtgxb ghznynz~ -D.& Jgzg-ebgfx xzgfjgtj bttlt li zmb ebgf. gtb tbptbxbfzgznyb li zmtbb nfjbpbfjbfz b}pbtnebfzx snzm xnenagt tbxrazx - f 5 70.&Xzgznxznhgaa~ xncfn hgfz jniibtbfhbx itle hlfztla -rfpgntbjz %zbxz!P 1 0&02. gtb jbflzbj d~ /&

Incrtb X4 Ztbgzebfz snzm ztgfx%[TrHa-[72UgfbF : .FLU4+

tbjrhbj h~zlknfb gfj FL ptljrhznlf gz zmb bfj li zmb zmbtg%pbrznh xhmbjrab& Xsnxx enhb sbtb nflhragzbj snzm 7 70 8

dallj zt~plegxznclzbx li Z& htr n xztgnf gfj ztbgzbj snzmztgfx%[TrHa-[72UgfbF : .FLU 4+ -8&88 eela,kc,jg~.! gfj,ltgxhltdnh ghnj -8&88 eela,kc,jg~.! gfj,lt dbf fnjg lab -8=2e ela,kc,jg~. ilt 40 hlfxbhrznyb jg~x& Zmb hlfztla ctlrptbhbnybj lfa~ PDX& Ilt jbzgnax lf zmb b}pbtnebfzga ptlzlhla!tbibt zl zmb abcbfj nf Incrtb 2& Fnztnzb -G. gfj NA%70! NIF%c gfjZFI%g -D. ptljrhznlf sbtb jbzbtenfbj nf zmb dallj xbtg lfjg~ 42 plxz%nfibhznlf -zmb agxz jg~ li ztbgzebfz. d~ BANXG gfjzmb Ctnbxx ebzmlj! tbxpbhznyba~& Jgzg gtb tbptbxbfzgznyb li zmtbb nfjbpbfjbfz b}pbtnebfzx snzm xnenagt tbxrazx! f 5 70&

Jgzg tbptbxbfz ebgfx XBE& /!+

gfj ( P 1

0&02! jniibtbfzx~edlax nfjnhgzb xncfn hgfz jniibtbfhb&




13/13

Incrtb X8 Zmb ztbgzebfz snzm ztgfx%[TrHa-[72UgfbF : .FLU 4+

nfjrhbx g pgtgxnzlalcnhga hrtb nf Z& htr n%nfibhzbj enhb& Xsnxxenhb sbtb nflhragzbj snzm 7 70 8 dallj zt~plegxznclzbx li Z&htr n ^ xztgnf gfj ztbgzbj snzm ztgfx%[TrHa-[72UgfbF : .FLU 4+

-8&88 eela,kc,jg~.! gfj,lt gxhltdnh ghnj -8&88 eela,kc,

jg~.! gfj,lt dbf fnjg lab -8=2 e ela,kc,jg~. ilt 40 hlfxbhr%znyb jg~x& Zmb hlfztla ctlrp tbhbnybj lfa~ PDX& Ilt jbzgnax lfzmb b}pbtnebfzga ptlzlhla! tbibt zl zmb abcbfj nf Incrtb 2& Zmbwrgfzn hgznlf li Z& htr n%xpbhn h neerflcaldranf C gfzndlj%nbx nf zmb dallj xbtg -G. gfj tbga%zneb PHT gfga~xnx ilt zmbptbxbfhb li Z& htr nJFG nf zmb e~lhgtjnre -D. sbtb pbt%iltebj 22 jg~x gizbt nfibhznlf -7 elfzm gizbt zmb bfj li ztbgzebfz.& Flzb zmgz zmb xbtre abybax li Z& htr n%xpbhn h

neerflcaldranf C gfzndljnbx gx sbaa gx zmb abybax li pgtgxnzbJFG nf zmb gfnega ctlrpx ztbgzbj snzm zmb FL jlflt parx Dgtb tbegtkgda~ als gfj gtb ybt~ xnenagt zl smgz nx xbbf ilt zmbrfnfibhzbj hlfztla ctlrp& Jgzg tbptbxbfz ebgfx XBE gfjgtb tbptbxbfzgznyb li zmtbb nfjbpbfjbfz b}pbtnebfzx snzm

xnenagt tbxrazx -rfpgntbj z %zbxz!P 1 0&02. -f 5 70.& PDX! pmlx%pmgzb driibtbj xganfb&

Pabgxb flzb? Snab~%Daghksbaa gtb flz tbxplfxndab ilt zmbhlfzbfz lt irfhznlfganz~ li gf~ xrppltznfc egzbtngax xrppanbjd~ zmb grzmltx& Gf~ wrbtnbx -lzmbt zmgf enxxnfc egzbtnga.xmlraj db jntbhzbj zl zmb hlttbxplfjnfc grzmlt ilt zmbgtznhab&



Nitric oxide donor trans-[RuCl([15]aneN)NO] as a possible therapeutic approach for Chagas' disease.

Documents

Transcript of Nitric oxide donor trans-[RuCl([15]aneN)NO] as a possible therapeutic approach for Chagas' disease.