being

for 6RANTSNIH GUIDE U S DEPARTWENT OF HEALTH. EDUCATION, AND WLFARE

Vol. 6 , No. 2 1 , December 1, 1977

I N T H I S ISSUE: d

REQUEST FOR A P P L I C A T I a N S FOR S P E C I A L I N I T I A T I V E GRANTS FOR RESEARCH ON AGING

F i r s t a p p l i c a t i o n receipt da t e is January 2 , 1978. Page 1

GRANT A P P L I C A T I O N S ON PULMONARY C I L I A R Y STRUCTURE AND FUNCTION SOUGHT BY THE D I V I S I O N OF LUNG DISEASES, NATIONAL HEART, LUNG, AND BLOOD I N S T I T U T E

F i r s t a p p l i c a t i o n r e c e i p t da t e is March 1, 1978. Page 5

GRANT A P P L I C A T I O N S ON MEMBRANE TRANSPORT I N THE LUNG SOUGHT BY THE D I V I S I O N OF LUNG DISEASES, NATIONAL HEART, LUNG, AND BLOOD I N S T I T U T E

F i r s t a p p l i c a t i o n r e c e i p t da t e is March 1, 1978. Page 6

RESEARCH GRANT A P P L I C A T I O N S SOUGHT FOR I N VITRO RESPONSES O F THE LUNG TO PATHOGENETIC SUBSTANCES

The Nat iona l Heart, Lung, and Blood I n s t i t u t e and ,the National I n s t i t u t e of Allergy and I n f e c t i o u s Diseases are i n t e r e s t e d i n expanding research a c t i v i t i e s coiicerned w i t h t h e hos t response of the lung t o s imple chemicals , inorganic and o rgan ic d u s t s , and au toant igens . Page 7

(over)

1 HAVE XOU NOVED? 1 If your present addmss differs f r o m that sham on the address label, please eend your na, addretra to: Cmntcr and Contnwt Guide Diatributwn Center, Division of Resaarch G r a t e , NIH. Room 219, V~lstwood h i t d i n g , &thhsda, Ehryland 20014, and attach youraddress label to your let ter. Prompt notioe of yourchange of address oil1 prevent your mzm from removed f r o m our mailing l i s t . -

fie GUIDE is pubtiahed a t ir~egu2a.rintervats to provide policy and acbninistrative infomation to individuak and organizations uho need t o be kept i n f o n e d o f requirements and changes in grants and contracts a c t i v i t i e s aht inis temd by the NationaZ I n ~ t i t u t e sof HeaZth.

Supplemenh, printed on yettow paper, am pubZished by the respective W a d n g waits concerning m projecte, s o ~ i c i t a t w mof 8ource6, and

2wqueetS f o r propoea~e.

-NONDISCRIMINATION ON THE B A S I S OF HANDICAP

At ten t ion i s c a l l e d t o new HEW Regula t ions .

FALSE STATEMENTS

Reminder regard ing f a l s e s t a t emen t s i n d e a l i n g wi th t h e Federa l Government.

NONHUMAN PRIMATES A V A I L A B L E

Rhesus and s q u i r r e l monkeys a v a i l a b l e . P r i o r i t y t o be g iven t o r eques t s f o r use on N I H and ADAMHA suppor ted p r o j e c t s rece ived p r i o r t o January 1, 1978; t h e r e a f t e r a l l r eques t s honored on a f i r s t - c o m e l f i r s t ­served b a s i s .

ANIMAL RESOURCES DIRECTORY NOW A V A I L A B L E

A 56-page d i r e c t o r y desc r ib ing t h e animal r e sources of N I H ’ s Div i s ion of Research Resources has been published and is a v a i l a b l e f r e e .

MANPOWER DEVELOPMENT PROGRAMS I N DIABETES, *

ENDOCRINOLOGY, AND METABOLIC D ISEASES

Announcing continued a v a i l a b i l i t y of suppor t i n t h e areas of c l i n i c a l and b a s i c s c i e n c e s r e l e v a n t t o mission of NIAMDD. Three programs : Nat iona l Research Se rv ice Awards, Research Career Development Awards, and C l i n i c a l I n v e s t i g a t o r Awards.

S P E C I A L EMPHASIS RESEARCH CAREER AWARD N H L B I AND NIAMDD

Establishment and a v a i l a b i l i t y of S p e c i a l Emphasis Research Career Award - Diabetes M e l l i t u s : cardio­v a s c u l a r , metabol ic , and endoc r ino log ic a s p e c t s .

R E V I S I O N OF GUIDELINES CANCER CONTROL PROGRAM

Revision of page 5 , S e c t i o n C . of Vol. 4 , No. 7 , pages 3 - 6 , of NIH Guide for Grants and Contracts.

Page 8

Page 8

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Page 9

Page 11

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IN THIS ISSUE: (cont inued)

COPYRIGHT POLICY NOTICE TO A L L GRANTEES

The new copyr ight l a w becomes e f f e c t i v e January 1, 1978; grantees and p r i n c i p a l i n v e s t i g a t o r s should become f a m i l i a r w i th i t s e f f e c t on c e r t a i n s c i e n t i f i c pub;!ications. Page 1 5

N I H PEER REVIEW PROCESS ARTICLES A V A I L A B L E

Articles desc r ib ing i n d e t a i l the process ing of pee r review re sea rch g r a n t a p p l i c a t i o n s ar: t he Nat iona l I n s t i t u t e s of Heal th - o r i g i n a l l y publ ished i n Federation Proceedings. Page 1 6

W'

NIH Guide for Grants and Contracts Vol . 6, No. 21, December 1 , 1977 Page Five

W'

W

GRANT APPLICATIONS ON PULMONARY CILIARY

STRUCTURE AND FUNCTION SOUGHT BY THE

DIVISION OF LUNG DISEASES, NATIONAL I / / / / / / / / / / /

HEART, LUNG, AND BLOOD INSTITUTE

The S t r u c t u r e and Funct ion Branch of t h e Div is ion of Lung Diseases, Nat iona l Heart, Lung, and Blood I n s t i t u t e is i n t e r e s t e d i n expanding research act ivi t ies concerned wi th t h e s t r u c t u r e and func t ion of pulmonary c i l i a t o invo lve such d i s c i p l i n e s as b iochemis t ry , b iophys ics , physiology, pathology, and cell b io logy .

Mucoci l iary t r a n s p o r t is considered t o be an important defense mechanism a g a i n s t i nha led tox ican t s and microorganisms. Never the less , l i t t l e is known about pul­monary c i l i a , t h e i r s t r u c t u r e , how they func t ion , and how t h e i r a c t i v i t y i s con t ro l l ed .

Most knowledge of t h e movement and biochemistry of c i l i a has been der ived by e x t r a p o l a t i o n from work wi th u n i c e l l u l a r organisms o r i n v e r t e b r a t e s . Although the biochemistry and t h e b a s i c mechanisms of m o t i l i t y may be the same i n mam­malian ce i l ia as i n t h e more primitive ones, t h e p a t t e r n of movement and mechanism of c o n t r o l are s p e c i a l i z e d f e a t u r e s t h a t vary from organism t o organism and from t i s s u e t o t i s s u e . No f u n c t i o n a l s t u d i e s of mammalian lung c i l i a can r e l i a b l y be regarded as r e f l e c t i n g t h e normal s i t u a t i o n because the a c t i v i t y of the c i l i a , and the amount and na tu re of s e c r e t o r y a c t i v i t y , may be per turbed by p r e p a r a t i v e procedures .

Recent ly , primary abnorma l i t i e s i n t h e f i n e s t r u c t u r e of human b ronch io la r c i l i a have been observed i n persons wi th s i t u s inve r sus , chronic s i n u s i t i s and b r o n c h i e c t a s i s (Kartagener 's t r i a d ) which i s a n i n h e r i t e d syndrome a s s o c i a t e d wi th repea ted pulmonary i n f e c t i o n s . But whether o t h e r g e n e t i c d e f e c t s i n c i l i a r y s t r u c t u r e may be a s s o c i a t e d wi th pulmonary d i s o r d e r s i s e n t i r e l y unknown. Nor is i t known how exogenous ( t o x i c a n t s , pharmacological agen t s ) o r endogenous (hormones, mediator) compounds a f f e c t c i l i a and t h , e i r func t ion .

The purpose of t h i s announcement is t o encourage submission of r e sea rch g ran t a p p l i c a t i o n s which focus on i n vivo o r i n v i t r o s t u d i e s of t h e s t r u c t u r e and func t ion of normal mammalian c i l i a from t h e upper lower r e s p i r a t o r y t ract . S tud ie s may be addressed t o morphological, b iophys ica l , and mechanical a s p e c t s , o r may e l u c i d a t e biochemical and cytochemical c h a r a c t e r i s t i c s and t h e func t ion of c i l i a t e d e p i t h e l i a l cells .

Deadlines f o r t he r e c e i p t of g r a n t a p p l i c a t i o n s are March 1, Ju ly 1, and November 1. Review of a p p l i c a t i o n s and award of g r a n t s concerned wi th s t r u c t u r e and func t ion of pulmonary c i l i a w i l l be through usua l N I H procedures .

A t t he t i m e of submission of a n a p p l i c a t i o n , a copy of page one ( f a c e page) and page two b b s t r a c t o f proposed research) should be s e n t t o D r . B i t t e n S t r i p p , Chief , S t r u c t u r e and Funct ion Branch, Div is ion of Lung Diseases, Nat iona l Heart, Lung, and Blood I n s t i t u t e , Room 6A10, 5333 Westbard Avenue, Bethesda, Maryland 20016. I n q u i r i e s regard ing t h i s program may be addressed t o D r . B i t t e n S t r i p p a t (301) 496-7171.

P a g e S i x

GRANT APPLICATIONS ON MEMBRANE TRANSPORT I N

THE LUNG SOUGHT BY THE D I V I S I O N OF LUNG I

DISEASES, NATIONAL HEART, LUNG,

AND BLOOD I N S T I T U T E

(ANNOUNCEMENT?' / , / / / / / / / / /

The S t r u c t u r e and Function Branch of the Div is ion of Lung Diseases, Nat ional Heart , Lung, and Blood I n s t i t u t e is i n t e r e s t e d i n expanding research a c t i v i t i e s concerned wi th nonresp i ra tory func t ions of t he lung t o involve e x p e r t i s e i n fundamental d i s c i p l i n e s such as biochemistry, physiology, c e l l b io logy , and pharmacology, and t o s tudy mechanisms by which endogenous o r exogenous compounds (except gases) are t r anspor t ed ac ross e p i t h e l i a l , e n d o t h e l i a l , o r i n t e r s t i t i a l c e l l boundaries .

The mechanism of membrane t r a n s f e r of water, e l e c t r o l y t e s , d rugs , and macro-molecules have been s t u d i e d i n t e n s i v e l y over t h e p s s t 20 yea r s i n t h e gastro­i n t e s t i n a l t r a c t , t he s k i n and the r e n a l t ubu le s , and ac ross b loodfb ra in and b lood /b i l e b a r r i e r s , and have l e d t o va luable t h e r a p e u t i c d i scove r i e s . S imi l a r s t u d i e s , however, have not been carr ied o u t i n the lung. Never the less , water and i o n movements are important de te rminants i n t h e composition of mucus and p e r i c i l i a r y f l u i d and may t h e r e f o r e play a s i g n i f i c a n t r o l e i n the lung defense s y s t e m . Moreover, t r a n s p o r t and accumulation of drugs , macromolecules, o r t o x i c chemicals may be t h e f i r s t s t e p i n a series of events t h a t l ead t o s e r i o u s pulmonary d i s o r d e r s .

The purpose of t h i s announcement is t o encourage submission of research g r a n t a p p l i c a t i o n s which focus on mechanisms f o r t r a n s p o r t of water , e l e c t r o l y t e s , endogenous compounds, d rugs , and macromolecules ac ross the t r a c h e a l , b r o c h i o l a r , and a l v e o l a r ep i the l ium, ac ross t h e vascu la r endothelium and ac ross membranes of ce l l s i n t h e i n t e r s t i t i u m .

Deadl ines f o r t he r e c e i p t of g r a n t a p p l i c a t i o n s are March 1, Ju ly 1, and November 1. Review of a p p l i c a t i o n s and award of g r a n t s concerned wi th t r a n s p o r t s t u d i e s i n t h e lung w i l l b e through usua l N I H procedures .

A t t h e t i m e o f submission of an a p p l i c a t i o n , a copy of page one ( f a c e page) and page two ( a b s t r a c t of proposed research) should be s e n t t o D r . B i t t e n S t r i p p , Chief , S t r u c t u r e and Function Branch, D iv i s ion of Lung Diseases, Nat iona l Heart, Lung, and Blood I n s t i t u t e , Room 6A10, 5333 Westbard Avenue, Bethesda, Maryland 20016. I n q u i r i e s regard ing t h i s program may be addressed t o D r . B i t t e n S t r i p p a t (301) 496-7171.

‘Hw’

U

NIH Guide f o r Grants and Contracts Vol . 6 , No. 21, December 1 , 1977 Page Seven

RESEARCH GRANT APPLICATIONS SOUGHT

FOR I N VITRO RESPONSES OF THE LUNG

TO PATHOGENETIC SUBSTANCES

The Divis ion of Lung Diseases, Nat iona l Heart, Lung, and Blood I n s t i t u t e and t h e Nat iona l I n s t i t u t e of Allergy and I n f e c t i o u s Diseases are i n t e r e s t e d i n expanding research ac t iv i t ies concerned wi th t h e h o s t response of t h e lung t o s imple chemicals , i no rgan ic and o rgan ic d u s t s , and au toant igens . S tud ie s of t h e b a s i c response mechanisms of t h e lung t o such inha led agents are requi red t o i d e n t i f y t h e even t s which i n i t i a t e o r exacerba te f i b r o t i c lung d i s e a s e s . Such s t u d i e s w i l l involve e x p e r t i s e i n fundamental d i s c i p l i n e s such as immunology, microbiology, biochemistry, and physiology.

A v a r i e t y of ch ron ic and progress ive pulmonary d i s e a s e s r e s u l t from t h e i n h a l a t i o n of o rgan ic o r i no rgan ic material. Agents which are known t o produce c e l l u l a r i n f i l t r a t i o n and/or f i b r o s i s i n the lung inc lude such d i v e r s e subs tances as pigeon droppins , fung i , act inomycetes , n i t r o f u r a n compounds, s i l i c a , and bery l l ium salts. Although s t u d i e s have i n v e s t i g a t e d t h e in f luence of t h e s e agents on lung d i s e a s e , l i t t l e is known regard ing the c e l l u l a r responses of t h e lung t o t h e s e and o t h e r inha led agents o r of t he e x t e n t t o which these responses are p r o t e c t i v e o r d e s t r u c t i v e . Inha led subs tances may produce changes i n immunologicaily-active cells r e s u l t i n g i n de t r imen ta l e f f e c t s which may o r may not be of an immunologic na tu re . It is a l s o p o s s i b l e t h a t a u t o r e a c t i v e responses , such as t h e product ion of a n t i n u c l e a r ant ibody, might arise as a r e s u l t of pre l iminary c e l l u l a r damage caused by a n inha led agen t , and t h a t such auto-immune phenomena might p lay a r o l e i n ch ron ic lung d i s e a s e i n i t i a t e d by t h e i n c i t i n g agent . The purpose of t h i s announcement is t o encourage i n v i t r o s t u d i e s of t h e h o s t response of t he lung t o f i b r o s i s and/or c e l l u l a r - i n f i l t r a t i o n -producing agents .

Deadlines f o r t h e r e c e i p t of g r a n t a p p l i c a t i o n s are March 1, Ju ly 1, and November 1. Rev iew and award of a p p l i c a t i o n s concerned wi th t h e s e s t u d i e s w i l l be through the usual N I H procedures . Assignment of a p p l i c a t i o n s to NHLBI o r NIAID w i l l be made by the Division of Research Grants, N I H , and w i l l be deter-mined by t h e major focus of t h e proposed r e sea rch o b j e c t i v e s . In g e n e r a l , t hose a p p l i c a t i o n s designed t o i n v e s t i g a t e mechanisms of lung d i s e a s e w i l l be ass igned t o NHLBI; t hose r e l a t e d t o immunologic processes w i l l be ass igned t o N I A I D .

I n o rde r t o a ler t t h e I n s t i t u t e s of submission of an a p p l i c a t i o n i n response t o t h i s announcement, a copy of t h e cover page of t h e a p p l i c a t i o n should be forwarded both t o Hugh B . Stamper, Jr . , Ph.D., Div is ion of Lung Diseases, NHLBI , N I H , Room 6A03, Westwood Building, 5333 Westbard Avenue, Bethesda, Maryland 20016, and t o Sheldon Cohen, M.D., Immunology, A l l e r g i c , and Immunologic Diseases Program, N I A I D , N I H , Room 7A52, Building 31, Bethesda, Maryland 20014.

P a g e E i g h t

NONDISCRIMINATION ON THE

B A S I S OF HANDICAP

The a t t e n t i o n of a l l g ran tees and c o n t r a c t o r s is c a l l e d t o new HEW Regulations (45 CFR 84) e n t i t l e d : Nondiscrimination on t h e Basis of Handicap i n Programs and A c t i v i t i e s Receiving o r Bene f i t i ng from Federa l F i n a n c i a l Ass is tance . These f i n a l r u l e s appeared i n t h e Federal Reg i s t e r on May 4 , 1977, and are now i n e f f e c t . Many N I H g ran tees and c o n t r a c t o r s w i l l have rece ived a copy of t hese r e g u l a t i o n s and assurance forms d i r e c t l y from HEW. Those t h a t have no t rece ived e i t h e r t h e r e g u l a t i o n s o r t h e forms should c o n t a c t M r . John Wodatch, D i rec to r , O f f i c e of New Programs, O f f i c e f o r C i v i l R igh t s , Department of Heal th , Education, and Welfare, Washington, D.C. 20201; telephone: (202) 245-1821.

FALSE STATEMENTS / / / / / / /

5 NOTICE? / / / / / / I /

I n any d e a l i n g wi th the Federa l Government i t is a crime knowingly and w i l l f u l l y : (1) to f a l s i f y , conceal, or cover up any material fact, or (2) to make any false o r f r audu len t s ta tement o r r e p r e s e n t a t i o n , o r ( 3 ) t o make o r use any f a l s e docu­ment knowing i t t o con ta in any f a l s e , f i c t i t i o u s , o r f r audu len t s ta tement (18 U.S.C. 5 1001). This crime is punishable by up t o $10,000 i n f i n e s , imprisonment f o r up t o f i v e y e a r s , o r both.

NONHUMAN PRIMATES A V A I L A B L E

The Nat iona l I n s t i t u t e s of Health has e s t a b l i s h e d s e v e r a l supply sources of nonhuman pr imates . These sources were e s t a b l i s h e d i n t h e f a c e of c u r r e n t and pending shor t ages i n nonhuman pr imates t o a s s u r e a supply of animals f o r National I n s t i t u t e s of Health (NIH) and Alcohol, Drug Abuse, and Mental Health Adminis t ra t ion (ADAMHA) supported p r o j e c t s . Animals w i l l be a v a i l a b l e from these sou rces i n t h e nea r f u t u r e as fo l lows:

Rhesus and S q u i r r e l Monkeys

During t h e pe r iod from December 1, 1 9 7 7 , t o March 1, 1978, t h e fo l lowing animals w i l l be a v a i l a b l e :

10 male s q u i r r e l monkeys (Sa imi r i s c i u r e u s ) of Colombian s t o c k , 12-18 months old, weighing 500-600 gm.

9 male and 1 5 female s q u i r r e l monkeys (Sa imi r i s c i u r e u s ) of Guyanan s t o c k , 3-4 months o l d , weighing 300-400 gm.

2 male and 55 female s q u i r r e l monkeys (Sa imi r i s c i u r e u s ) , a d u l t excess breeders of Guyanan o r i g i n

NIH Guide for Grants and Contracts Vol . 6, No. 21 , December I , 1977 Page Nine

W 3 male and 1 female rhesus monkeys (Macaca inu la t t a ) , 24-27 months o l d , weighing 3-4 kg.

100 male and 7 female rhesus monkeys (Macaca inu la t ta ) , 12-24 months o l d , weighing 1-3 kg.

80 male and 65 female rhesus monkeys (Macaca m u l a t t a ) , 0-12 months o l d , weighing up t o 1 kg.

Except f o r t h e a d u l t s q u i r r e l monkeys, t hese animals are domest ica l ly b red and reared i n a c o n t r o l l e d colony environment. The diltes of b i r t h and t h e parentage are a v a i l a b l e upon r eques t . Unless s p e c i f i c a l l y :requested o therwise , t h e rhesus monkeys, b u t no t t h e s q u i r r e l monkeys, w i l l be vacc ina ted a g a i n s t measles. Requests f o r s p e c i a l handl ing and procedures w i l l be considered.

I n v e s t i g a t o r s i n nonpro f i t i n s t i t u t i o n s who wish to o b t a i n animals from t h e above groups f o r use i n biomedical and behav io ra l p r o j e c t s are i n v i t e d t o submit r e q u e s t s f o r them. The r eques t s i n le t ter form should indficate t h e source of suppor t f o r t he us ing p r o j e c t and, i f suppor ted by N I H o r ADAMHA, t h e t i t l e and number of t he g r a n t o r c o n t r a c t . The r e q u e s t should also inc lude a s p e c i f i c a t i o n of t h e animals r equ i r ed , i nc lud ing number, age , s ex , o r o t h e r s p e c i a l c h a r a c t e r i s t i c s , and s ta te what, i f any requirement t h e r e w i l l be t o o b t a i n animals from captive-bred sources i n f u t u r e y e a r s . Such requirements f o r f u t u r e supply from captive-bred sources w i l l be honored whenever f e a s i b l e . The e n t i r e r eques t should no t exceed one typewr i t t en page. It should be addressed t o D r . Char les McPherson, Chief , Animal Resources Branch, D iv i s ion of Research Resources, Room 5B59, Bui ld ing 31, Nat iona l I n s t i t u t e s of Heal th , Bethesda, Maryland 20014. P r i o r i t y w i l l be given t o r eques t s f o r use on N I H and ADAMHA suppor ted p r o j e c t s rece ived p r i o r t o January 1, 1978, and a f t e r t h a t , a l l r eques t s honored on a f i r s t-come/ f irst-served b a s i s .

The r e c i p i e n t s of t h e animals w i l l be r equ i r ed t o pay a f e e which w i l l i n c o r p o r a t e sh ipp ing c o s t s f o r each animal. The f e e w i l l be $315 each f o r t h e rhesus monkeys and $240 each f o r t h e s q u i r r e l monkeys. These f e e s w i l l be pa id d i r e c t l y t o t h e c o n t r a c t o r supply ing t h e animals and w i l l be c r e d i t e d t o t h e NIH-supported breeding program t o provide p a r t i a l suppor t f o r t h l e b reeding co lon ie s .

ANIMAL RESOURCES DIRECTORY

Y A 56-page t h e animal r e sources of N I H ' s Div is ion o f Research

and is a v a i l a b l e f r e e .

Resources Directory, t he bookle t is in tended assistance and c o l l a b o r a t i o n invo lv ing

) 1,b

I n a d d i t i o n t o the complete l i s t i n g of N I H ' s major P r i m a t e Research Centers , the d i r e c t o r y i d e n t ies animal d i agnos t i c l a b o r a t o r i e s , animal information p r o j e c t s , animal r e fe renceY\>supported by DRR. e n t e r s , and s p e c i a l colony and model s tudy cen te r s c u r r e n t l y 1-u.

The Directory i n d i c a'L~ e sthe p e r v i c e s provided, areas of research i n t e r e s t , //.

p r i n c i p a l i n v e s t i g a t o r s o r d i r e c t o r s , addresses , and telephone numbers. A con tac t person i s i d e n t i f i e d f o r each resource .

A geographic index is inc luded , l i s t i n g resources by S t a t e , and wi th in each S t a t e . A map shows the l o c a t i o n s of the P r i m a t e Research Centers and animal d i agnos t i c l a b o r a t o r i e s throughout t he country.

A s i n g l e f r e e copy of Animal A Research Resources Zrec tory may be secured by w r i t i n g t o t h e Information Center , 1776 East J e f f e r s o n S t r e e t , Rockvi l le , Maryland 20852, o r by reques t from the Of f i ce of Science and Heal th Reports , Div is ion of Research Resources, Nat iona l I n s t i t u t e s of Heal th , Bethesda, Maryland 20014.

N I H G u i d e f o r G r a n t s a n d C o n t r a c t s V o l . 6, No. 2 1 , D e c e m b e r 1 , 1977 P a g e E l e v e n

W

MANPOWER DEVELOPMENT PROGRAMS I r i

D IABETES , ENDOCRINOLOGY ,

AND METABOLIC DISEASES

The Diabetes , Endocrinology, and Metabolic Diseases Program of t h e Nat iona l I n s t i t u t e of A r t h r i t i s , Metabolism, and Diges t ive Diseases announces the continued a v a i l a b i l i t y of suppor t f o r manpower development programs i n t h e areas of c l i n i c a l and b a s i c s c i ences r e l evan t t o i t s mission. The programs f a l l i n t o t h r e e c a t e g o r i e s :

.1. Nat iona l Research Serv ice Awards These awards are made t o i n d i v i d u a l s ( fe l lowships) o r t o i n s t i t u t i o n s ( t r a i n i n g programs) f o r t he suppor t of fu l l - t ime research t r a i n i n g r e l a t e d t o d i a b e t e s , endocrinology, and metabol ic d i seases .

2. Research Career Development Award This 'program is employed t o f o s t e r t he development of s c i e n t i s t s wi th outs tanding r e sea rch p o t e n t i a l who r e q u i r e experience i n a product ive s c i e n t i f i c environment i n p repa ra t ion f o r a c a r e e r of independent research . This award provides s a l a r y suppor t f o r f i v e yea r s t o i n d i v i d u a l s who have completed s i g n i f i c a n t p o s t d o c t o r a l research .

3 . Clinical I n v e s t i g a t o r Award This award provides the oppor tuni ty f o r promising c l i n i c a l l y - t r a i n e d i n d i v i d u a l s wi th demonstrated a p t i t u d e i n r e sea rch t o develop i n t o independent i n v e s t i g a t o r s . It provides t h r e e y e a r s of suppor t f o r t he s a l a r y and research ac t iv i t ies of i n d i v i d u a l s wi th four t o seven yea r s of c l i n i c a l and r e sea rch exper ience beyond the c l i n i c a l degree. Like the Research Career Development Award, t h i s award i s designed t o provide exper ience i n a product ive s c i e n t : i f i c environment i n p r e p a r a t i o n f o r a c a r e e r of independent research .

Although t h e DEMD Program i n v i t e s a p p l i c a t i o n from q u a l i f i e d i n d i v i d u a l s f o r each of these awards, t h e Program is p a r t i c u l a r l y i n t e r e s t e d i n encouraging t h e submission of i n s t i t u t i o n a l Nat iona l Research Serv ice Award a p p l i c a t i o n s . This Program permi ts g r e a t e r f l e x i b i l i t y t o t h e p r i n c i p a l i n v e s t i g a t o r i n making commitments and appointments of i n d i v i d u a l s t o the Program, as w e l l as be ing a mechanism e s p e c i a l l y s u i t a b l e f o r exposing the t r a i n e e s o r fe l lows t o a v a r i e t y of t r a i n i n g exper iences .

Appl ica t ions f o r i n d i v i d u a l Nat iona l Research Se rv ice Awards, i n s t i t u t i o n a l Nat iona l Research Se rv ice Awards, N I H Career Development Awards, and NIAMDD C l i n i c a l I n v e s t i g a t o r Awards are accepted i n accord with the u s u a l N I H app l i ca ­t i o n r e c e i p t d a t e s of February 1, June 1, and Octo'ber 1.

Should you d e s i r e f u r t h e r information about any of t h e programs o u t l i n e d above, p l ease feel f r e e t o wr i t e , o r c a l l t he Assoc ia te D i rec to r �or Diabetes , Endocrine, and Metabol ic Diseases, NIAMDD, Room 91247, Bui lding 31 , Bethesda, Maryland 20014; te lephone: (301) 496-6983.

Page Twelve

ESTABLISHMENT AND AVAILABILITY OF

SPECIAL EMPHASIS RESEARCH CAREER AWARD ?

DIABETES MELLITUS: CARDIOVASCULAR, METABOLIC

AND ENDOCRINOLOGIC ASPECTS

NATIONAL HEART, LUNG,\ND BLOOD INSTITUTE \ /

-AND \ // I

NATIONAL INSTITUTEOF A R T H R ~ I S, METABOLISM, t / / / / / / / / / / /

AND DIGESTIVE DISEA /,A~WOUWCLMENT;,/ / / / 4 '' \

I

This award i s intended t o : i

0 encourage q u a l i f i e d i n d i v i d u a l s i n the i ea r ly s t a g e s of t h e i r pos tgraduate medical and s c i e n t l f i c cafeers t o develop r e sea rch i n t e r e s t s and s k i l l s i n t h e metabol ic , / endocrinologic , and card iovascular a spec t s of d i abe te s m e l l i t u s ;

0 provide suppor t f o r i nd iv idua l s t o pursue a program of r e sea rch i n var ious fundamental and c l i n i c a l wesearch d i s c i p l i n e s related t o d i a b e t e s m e l l i t u s and i t s s e q u e l a h a t one o r more domestic i n s t i t u t i o n s which o f f e r s u p e r i o r and

0 create a pool of h ighly q u a l i f i e d and s k i l l s i n t he card iovascular , a s p e c t s of d i abe te s m e l l i t u s f o r a and c l i n i c a l care. b

TLis new award provides the opportunity; f o r a n i n d i v i d u a l wi th developing r-Jsearch i n t e r e s t s t o acqu i r e exper ience and s k i l l i n t h e broad fundamental a;.d c l in ica l s c i e n t i f i c d i s c i p l i n e s essential f o r a m u l t i d i s c i p l i n a r y approach t o t h e s tudy of t he metabol ic , endocr inologic , and ca rd iovascu la r a spec t s of d i a b e t e s m e l l i t u s . I n c o n t r a s t t o e x i s t i n g N I H awards which encourage the development of s k i l l s i n a s i n g l e d i s c i p l i n e w i t h i n a s i n g l e

J l abo ra to ry , t h i s Spec ia l Emphasis Research Career Award (SERCA) emphasizes in-depth exper ience i n s e v e r a l fundamental and c l i n i c a l s c i e n t i f i c d i s c i p l i n e s-''q which are not dependent upon a s i n g l e l abora to ry o r i n s t i t u t i o n .

"i (1 Provisions of the Award This nonrenewable award provides suppor t f o r a

f ive-year per iod of fu l l - t ime research and r e l a t e d a c t i v i t i e s . The la t ter --, ',, may inc lude r e sea rch development a c t i v i t i e s as w e l l as involvement i n

p a t i e n t care t o the e x t e n t t h a t i t w i l l s t r eng then research s k i l l s . The SERCA g r a n t made t o the awardees pa ren t i n s t i t u t i o n provides up t o $30,000 f o r fu l l - t ime s a l a r y support p lus f r i n g e b e n e f i t s . A maximum of $8,000 during t h e e a r l y phase and a supplement up t o $20,000 dur ing t h e las t two years w i l l be provided f o r necessary r e sea rch c o s t s inc luding t e c h n i c a l

N I H Guide f o r Grants and Cont rac ts Vol . 6, No. 21 , December 1 1977 Page T h i r t e e n

a s s i s t a n c e , equipment, s u p p l i e s , consu l t an t c o s t s , domestic t r a v e l , p a t i e n t Ir' care c o s t s , pub l i ca t ion , and o t h e r c o s t s .

The a p p l i c a n t i s expected to :

metabol ic , and endocr inologic as of d ' iabetes . This should

r s u e t h e s e a c t i v i t i e s i n more

Appl ica t ions must be submit ted on form t i o n s . Applic.ations must be received

I n q u i r i e s concerning

Extramural Affa Review Branch art , Lung, and B

Telephone: (301) 496-7915

NHLBI and NIAMDD w i l l be completed b e f o r e t h e end of May 1978, and approved awards w i l l b e funded beginning J u l y 1, 1978, a t the earliest .

P a g e Fourteen

R E V I S I O N OF G U I D E L I N E S

CANCER CONTROL PROGRAM

The NIH Guide for Grants and Contracts, Vol. 4 , No. 7 , pages 3-6, August 8 , 1975, contained the Nat iona l Cancer I n s t i t u t e , Div is ion of Cancer Control and R e h a b i l i t a t i o n ' s g ran t gu ide l ines f o r the Cancer Cont ro l Program; a c o r r e c t i o n appeared i n Vol. 5 , No. 1 2 , page 4 , August 6 , 1976. Page 5 , Sec t ion C . of the August 8, 1975,announcement should be r ev i sed as fol lows:

C. Rehabilitation/Continuing Care:

The DCCR w i l l suppor t sys t ema t i c , c a r e f u l l y c o n t r o l l e d research i n the areas l i s t e d below. It i s presumed t h a t the i n v e s t i g a t o r s w i l l have the appropr i a t e t e c h n i c a l background, t r a i n i n g , and experience i n the conduct of such research . Adequate f a c i l i t i e s t o ca r ry ou t t he proposed i n v e s t i g a t i o n s must be a v a i l a b l e .

1. Management of pa in i n cancer p a t i e n t s .

2. Psychosocial a spec t s of cancer as i t a f f e c t s t he p a t i e n t and the p a t i e n t ' s family. This area m a y include:

a . Development of methodologies �o r a s s e s s i n g the e f f e c t i v e n e s s of s e l e c t e d counsel ing techniques.

b . Development and assessment of procedures and techniques f o r more e f f e c t i v e counse l ing of p a t i e n t s and t h e i r f a m i l i e s .

c. Pa t i en t l f ami ly p a t t e r n s of competence.

3 . Psychological and psychosocial a spec t s of cancer as i t a f f e c t s h e a l t h p ro fes s iona l s .

4 . Morbidity of young a d u l t long-term su rv ivo r s .

5 . Dietary and n u t r i t i o n a l management of cancer p a t i e n t s inc lud ing feeding behavior , and i ts a l t e r a t i o n by d i s e a s e and/or t reatment .

6 . New approaches t o t h e r e h a b i l i t a t i o n problems of head and neck cancer p a t i e n t s i n r e l a t i o n t o cosmesis, speech, and swallowing.

7 . Development and eva lua t ion of new phys ica l techniques/procedures t o r e h a b i l i t a t e cancer p a t i e n t s wi th s p e c i f i c d e f i c i t s (amputa­t i o n , stoma, e t c . )

8. Development and eva lua t ion of new concepts and procedures f o r t he improved ca re of cancer p a t i e n t s with end-stage d i sease .

9 . Development and eva lua t ion of new b iomate r i a l s f o r b e t t e r p r o s t h e s i s cons t ruc t ion .

N I H Guide f o r Grants and Contracts Vol . 6 , No. 21 , December 1 , 1977 Page F i f t e e n

Anyone needing a completely new copy of t he guide:Lines ( inc luding the above r e v i s i o n ) may con tac t :

D r . Veronica L . Conley Divis ion of Cancer Control and R e h a b i l i t a t i o n Nat iona l Cancer I n s t i t u t e Room 7A07, Blair Building 8300 C o l e s v i l l e Road S i l v e r Spring, Maryland 20910

Telephone: (301) 427-7941

COPYRIGHT POLICY ,\\\ \\

\ \ \ \ \ \ \ \NOTICE TO ALL GRANTEES >POLJCYX

The new copyr ight l a w becomes e f f e c t i v e January l!,1978. p r i n c i p a l i n v e s t i g a t o r s should become f a m i l i a r wi th the e f f e c t of t h i s l a w

Grantees and

on c e r t a i n s c i e n t i f i c pub l i ca t ions .

Current Pub l i c Heal th Se rv ice po l i cy i s congruent w i th the new copyr ight l a w . ,publ i shed a r t i c l e which i s i d e n t i f i e d as r e s u l t i n g from work suppor ted i n

This po l i cy al lows an i n d i v i d u a l t o make a s i n g l e photocopy of a

f u l l o r i n p a r t from Pub l i c Heal th Se rv ice g r a n t funds. To assist u s e r s of t h i s po l i cy i n the i d e n t i f i c a t i o n of s c i e n t i f i c ar t ic les r e s u l t i n g from Pub l i c Heal th Se rv ice supported p r o j e c t s , au tho r s are requi red t o provide a c r e d i t l i n e o r foo tno te acknowledging the source of suppor t . We ask t h a t a l l g ran tees see t h a t such a n o t i c e r e g u l a r l y appear on publ ished art icles.

The p resen t PUS g r a n t copyr ight po l i cy promulgated a f t e r appropr i a t e publ ica­t i o n i n the F e d e r a 2 Register (Vol. 36, No. 118) and r e i s sued through publ ica­t i o n of the PHS Grants Pol i cy Statement [DHEW Pub l i ca t ion No. (OS) 77-50,000 (Rev.) October 1, 19761 reads as fol lows:

"Except as o therwise provided i n t h e cond i t ions o f t he award, t h e au tho r is f r e e t o a r r ange f o r copyr ight wi thout approval when p u b l i c a t i o n s o r s i m i l a r materials are developed from work under a PUS grant-supported p r o j e c t . Any such copyrighted materials s h a l l be s u b j e c t t o a roya l ty - f r ee , nonexclusive, and i r r evocab le l i c e n s e t o the Government t o reproduce them, t r a n s l a t e them, publ i sh them, u s e and d i spose of them, and t o a u t h o r i z e o t h e r s t o do s o f o r Government purposes. I n a d d i t i o n , communications i n primary s c i e n t i f i c j o u r n a l s publ i sh ing i n i t i a l r e p o r t s of o r i g i n a l research supported i n whole o r i n p a r t by PHS g ran t funds may be copyrighted by the jouirnal wi th the understanding t h a t i n d i v i d u a l s are au thor i zed to make, o r have made by any means a v a i l a b l e t o them, wi thout regard t o the copyr ight of the j o u r n a l , and, without r o y a l t y , a s i n g l e copy of any such a r t i c l e f o r t h e i r own use."

Page Sixteen

NIH PEER REVIEW PROCESS

ARTICLES AVAILABLE / / / / / / . / A three-par t series of ar t ic les desc r ib ing i n d e t a i l t h e process ing o f p e e r review re sea rch g r a n t a p p l i c a t i o n s a t t h e Nat iona l I n s t i t u t e s of Heal th has been w r i t t e n by D r . Cather ine Henley, h e a l t h sc i ence admin i s t r a to r of t he Div is ion of Research Resources.

The series w a s publ ished i n the J u l y , August, and September 1977 i s s u e s of Federation Proceedings.

Adapted from a document prepared f o r t h e Grants Peer Review Study Team, Nat iona l I n s t i t u t e s of Heal th , t he publ i shed series is broken down i n t o the fol lowing s e c t i o n s : (1) The Assignment and R e f e r r a l Process , ( 2 ) Review by a n I n t i t i a l Review Group, and (3 ) Review by an Advisory Board/Council.

All t h r e e ar t ic les have been r e p r i n t e d wi th t h e permission of Federation Proceedings and are a v a i l a b l e i n one s i n g l e copy e n t i t l e d Peer Review of Research Grant Applications a t the National Ins t i tu tes of Health from the Of f i ce of Science and Heal th Reports , D iv i s ion of Research Resources, Nat iona l I n s t i t u t e s of Heal th , Bethesda, Maryland 20014.

41.5. GOVERNMENT PRINTING OFFICE:1977 260-918/16 1 - 3