for 6RANTS h d NIH GUIDE

US. DEPARTMENT OF HEALTH. EDUCATION. AND WLFARE

Vol. 5 , No. 22 , December 20, 1976

I N T H I S ISSUE:

BIOMEDICAL RESEARCH DEVELOPMENT GRANT PROGRAM

Div i s ion of Research Resources' announcement; subprogram of Biomedical Research Support Grant Program . SPECIAL IZED C L I N I C A L RESEARCH CENTERS FOR PERIODONTAL D I S t A S E

National competit ion t o e s t a b l i s h l i m i t e d number of c l i n i c a l r e sea rch c e n t e r s devoted t o pe r iodon ta l d i s e a s e . Letter of i n t e n t due January 1, 1977; dead l ine f o r r e c e i p t of a p p l i c a t i o n s , February 15, 1977.

.Id REQUEST FOR RESEARCH GRANT APPLICATIONS: RFA B t T E S I N PRtGNANCY: Lk FtCTS ON M l t K S AND OFFSPRING

Announcement by Center f o r Research f o r Mothers and Children of t h e Nat ional I n s t i t u t e of Child Health and Human Development. Applicat ions t o b e submitted t o m e e t dead l ine d a t e s e s t a b l i s h e d by t h e Divis ion of

Page 1

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Page 7 Research Grants , N I H , f o r new re sea rch p r o j e c t g r a n t a p p l i c a t i o n s .

flAYE YOU MOYED?

If your present address dz'ppera from that shown on the address labet, please send your new address to: Room 2Al4, 5333 Westbard Avenue, Nat<onul Ins t%htes of XeaZth, Bethesda, Mluylkznd 211014, and attach your address label t o your l e t t e r . Prompt notice of your change of address m'Zt prevent your m e b e i w removed fran our mailing Es t .

d

!The GUIDE i s published a t irregular intervals to p r o v i d e policy and acbninistrative information to individuals and ozganizations who need t o be kept informed of requirements and changes i n grants and contracts ac t i v i t i e s acbninistered by the National Insti tutes of Health.

Supplements, printed on y e l l m paper, am published by the respectivecwarcking units concerning new projects, solicitations of sources, and =quests for proposa 2s.

N I H Guide f o r Grants and Contracts Vol . 5, No. 22, December 20, 1976 Page One

W BIOMEDICAL RESEARCH DEVELOPMENT

GRANT PROGRAM A N N O U N C E M E N T

The Div i s ion of Research Resources, Nat ional I n s t i t u t e s of Heal th , announces t h e establ ishment of t h e Biomedical Research Development Grant (BRDG) Program. This program i s intended t o he lp e s t a b l i s h s i g n i f i c a n t involvement i n bio­medical and/or behav io ra l r e sea rch i n new, s m a l l , and developing i n s t i t u t i o n s t h a t need a s t r o n g r e sea rch m i l i e u t o h e l p a s s u r e t h a t manpower f o r b a s i c biomedical o r behav io ra l r e sea rch , c l i n i c a l r e sea rch , o r o t h e r h e a l t h p r o f e s s i o n a l areas w i l l be w e l l t r a i n e d . The BRDG Program is a subprogram of t h e Biomedical Research Support Grant (BRSG) Program. Up t o 10 pe rcen t of t h e funds a v a i l a b l e f o r t h e BRSG Program may be a l l o c a t e d f o r t h i s new program. It is expected t h a t 12 t o 15 new awards w i l l b e made each yea r and t h a t t h e program w i l l be h igh ly competi t ive. P rospec t ive g ran tees w i l l be expected t o have a commitment t o i n c r e a s i n g and s u s t a i n i n g t h e i r biomedical o r behav io ra l r e sea rch c a p a b i l i t y , and t o o f f e r s t r o n g p o t e n t i a l f o r u l t i m a t e biomedical and/or behav io ra l r e sea rch exce l l ence as a r e s u l t of r e sea rch development i n i t i a t e d wi th BRDG support .

'd

E l i g i b i l i t y is l i m i t e d t o n o n p r o f i t and no t - fo r -p ro f i t i n s t i t u t i o n s which, during t h e la tes t 12-month per iod ending September 30, have r ece ived less than $200,000 ( d i r e c t and i n d i r e c t c o s t s ) i n Pub l i c Heal th Se rv ice (PHS) r e sea rch g r a n t s . Each i n d i v i d u a l campus of a multi-campus u n i v e r s i t y is considered as a s e p a r a t e " i n s t i t u t i o n . " S i m i l a r l y , each h e a l t h p r o f e s s i o n a l school is l i k e w i s e considered an " i n s t i t i t i o n , " even though i t may b e a component of a u n i v e r s i t y . I n s t i t u t i o n s t h a t r e c e i v e o t h e r PHS re sea rch development g r a n t support (e.g. t h e Minority Biomedical Support Program) are no t e l i g i b l e f o r t h e s e new BRDG awards.

App l i ca t ions m a y r eques t up t o t h r e e y e a r s of support ,with average funding of no more than $100,000 p e r yea r . Support may be extended by competi t ive renewal, b u t support t o one i n s t i t u t i o n may no t exceed a t o t a l of s i x y e a r s o r $600,000.

E l i g i b l e i n s t i t u t i o n s may o b t a i n a PHS re sea rch g r a n t a p p l i c a t i o n k i t (form PHS 398) from t h e Div i s ion of Research Grants , Westwood Building, Nat ional I n s t i t u t e s of Heal th , Bethesda, Maryland 20014. The i n s t r u c t i o n s f o r completing t h i s a p p l i c a t i o n form should b e followed except where they are modified by s p e c i a l i n s t r u c t i o n s f o r t h e BRDG a p p l i c a t i o n . Requests f o r t h e s e s p e c i a l i n s t r u c t i o n s , BRDG Program General P o l i c y and Information Statement, advice on t h e p r e p a r a t i o n of a p p l i c a t i o n s , and information about

. e l i g i b i l i t y o r o t h e r matters should b e addressed to :

Biomedical Research Development Grant Program Division of Research Resources Room 4B04, Bui lding 31 Nat iona l I n s t i t u t e s of Health Bethesda, Maryland 20014

J Telephone: (301) 496-6743

N I H G u i d e f o r Grants a n d C o n t r a c t s Vol . 5, No. 22, D e c e m b e r 20, 1976 P a g e Three

b/

SPECIALIZED C L I N I C A L RESEARCH CENTERS

FOR PERIODONTAL DISEASE A N N O U N C E M E N T

In t roduc t ion The Nat iona l I n s t i t u t e of Dental Research (NIDR) announces a n a t i o n a l compet i t ion t o e s t a b l i s h a l i m i t e d number of c l i n i c a l r e sea rch c e n t e r s devoted t o pe r iodon ta l d i seases . The o b j e c t i v e s of t h e proposed c e n t e r s are t o a c c e l e r a t e t h e development of new knowledge f o r t h e prevent ion , d i agnos i s , and t reatment of pe r iodon ta l d i seases by b r ing ing resources , f a c i l i t i e s , and manpower i n t o focus on t h e s e problems i n a concerted way. It is expected t h a t t h e c e n t e r s w i l l c a p i t a l i z e on f ind ings accrued from recen t microbio logic , immunologic, and pharmacologic i n v e s t i g a t i o n s . This i s t h e announcement of t h e N I D R ' s i n t e n t t o e s t a b l i s h c l i n i c a l research c e n t e r s and desc r ibes gu ide l ines f o r developing t h e a p p l i c a t i o n s .

Background Pe r iodon ta l d i s e a s e s are a group of inflammatory condi t ions a f f e c t i n g t h e t i s s u e s surrounding t h e r o o t s of t h e t e e t h . It is es t imated t h a t 94 m i l l i o n Americans have some form of pe r iodon ta l d i sease , and 32 m i l l i o n of t h e s e have advanced d i sease . With age, t h e d i s e a s e becomes more seve re i n t h e i n d i v i d u a l and more p reva len t i n t h e popula t ion . Thus, pe r iodon ta l d i s e a s e , i n i t s va r ious forms, c o n s t i t u t e s a major h e a l t h problem of inc reas ing concern i n our soc ie ty .

,~d The c u r r e n t t rea tment

methods are d i f f i c u l t and r e s u l t s are uncer ta in . Furthermore, pe r iodon ta l therapy c o s t s t h e American p u b l i c approximately $1.5 b i l l i o n each yea r even though only a f r a c t i o n of t h e ind iv idua l s r e q u i r i n g t rea tment a c t u a l l y r ece ive i t .

Objec t ives The broad o b j e c t i v e of t h e c l i n i c a l r e sea rch c e n t e r i s t o t r a n s l a t e b a s i c concepts , e s p e c i a l l y those of microbiology, immunobiology, and pharmacology, i n t o c l i n i c a l i n v e s t i g a t i o n s of pa t i en t s wi th pe r iodon ta l d i sease . Even though t h e main t h r u s t of t h e c e n t e r r e sea rch should b e c l i n i c a l , i t is recognized t h a t t h e proper s tudy of human s u b j e c t s may encompass a l abora to ry component. Animal s t u d i e s may a l s o b e appropr i a t e . S p e c i f i c a l l y , t h e c e n t e r should develop programs t o accomplish some o r a l l of t h e fol lowing t a sks :

1. E s t a b l i s h t h e causa t ive organisms i n pe r iodon ta l d i s e a s e s ,

2 . C l a r i f y t h e hos t response t o t h e s e causa t ive organisms,

3 . Perform c l i n i c a l s t u d i e s of t h e r a p e u t i c techniques and regimens,

4 . Develop prevent ive measures.

Although t h e subs tance of t h e research program may vary according t o t h e l o c a l e x p e r t i s e , i n t e r e s t , resources , and recrui tment p o s s i b i l i t i e s , a proposed c e n t e r should develop p r o j e c t s which re la te t o t h e above.

Page Four

C h a r a c t e r i s t i c s of a C l i n i c a l Research Center The sponsoring i n s t i t u t i o n is expected t o have an adeq,uate base of r e sea rch . It should provide r e sources and s e r v i c e s t o support e s t a b l i s h e d r e sea rch i n areas such as microbiology, immunology, and pharmacology and develop r e l e v a n t c l i n i c a l i n v e s t i g a t i o n s toward t h e establ ishment of such a c e n t e r . The c l i n i c a l r e sea rch c e n t e r should b e an i d e n t i f i a b l e o r g a n i z a t i o n a l u n i t w i t h i n an i n s t i t u t i o n o r among a group of i n s t i t u t i o n s and t h e sponsoring i n s t i t u t i o n should be w i l l i n g t o make a commitment of i t s r e sources and s t a f f t o i n s u r e t h e development, o p e r a t i o n , and f u n c t i o n of t h e proposed c e n t e r .

Mechanism and Length of Support The mechanism of support w i l l b e t h e g r a n t , b u t d i f f e r s from t h e r e g u l a r r e sea rch p r o j e c t g ran t i n i t s emphasis, o b j e c t i v e s , and t h e degree of coord ina t ion by t h e Na t iona l I n s t i t u t e of Dental Research. Centers may r e c e i v e support f o r a per iod of f i v e y e a r s , w i th con t inua t ion beyond t h i s pe r iod dependent upon a competing renewal a p p l i c a t i o n . Renewal a p p l i c a t i o n s w i l l be reviewed i n competi t ion wi th new a p p l i c a t i o n s , on an equa l b a s i s .

Re la t ionsh ip t o N I D R The award of c l i n i c a l r e sea rch c e n t e r g r a n t s w i l l e s t a b l i s h a s p e c i a l coope ra t ive r e l a t i o n s h i p between t h e NIDR and t h e g r a n t e e i n s t i t u t i o n . To accomplish t h i s , a program o f f i c e r w i l l b e designated by t h e N I D R t o work c l o s e l y wi th t h e s t a f f of t h e c l in i ca l r e sea rch c e n t e r . The program o f f i c e r w i l l make r e g u l a r v i s i t s t o each c l i n i c a l c e n t e r t o d i s c u s s p rogres s and t o provide a s s i s t a n c e . I n a d d i t i o n t o t h e review of annual progress r e p o r t s , p r o j e c t s i t e v i s i t s t o each center w i l l b e conducted on an annual b a s i s .

Admin i s t r a t ive Items and Costs The c l i n i c a l r e sea rch c e n t e r d i r e c t o r should b e a r e spec ted s c i e n t i s t a b l e t o provide both s c i e n t i f i c and a d m i n i s t r a t i v e l eade r sh ip . The d i r e c t o r w i l l b e r e s p o n s i b l e f o r t h e o rgan iza t ion and ope ra t ion of t h e c e n t e r and f o r communication wi th t h e NIDR on s c i e n t i f i c and o p e r a t i o n a l matters. The r e sea rch program f o r each c l i n i c a l c e n t e r w i l l b e guided by i t s own i n t e r n a l review board c o n s i s t i n g j o i n t l y of s t a f f members and o t h e r e x p e r t c o n s u l t a n t s n o t p a r t of t h e c l i n i c a l c e n t e r program. This board w i l l adv i se t h e c l i n i c a l center d i r e c t o r of i t s assessment of p rogres s on c u r r e n t p r o j e c t s and conduct an i n i t i a l review of new i n i t i a t i v e s .

The c e n t e r g r a n t may inc lude p i l o t p r o j e c t s as w e l l as a c l u s t e r of i n t e r r e l a t e d r e g u l a r p r o j e c t s . Funds may be u t i l i z e d f o r c e n t r a l support s e r v i c e s , equipment, s u p p l i e s , r enova t ions , c o n s u l t a t i o n s e r v i c e s , t r a v e l , and p u b l i c a t i o n c o s t s . Funds may a l s o b e u t i l i z e d f o r p r o f e s s i o n a l , t e c h n i c a l , and a d m i n i s t r a t i v e personnel . However, each p a r t i c i p a t i n g s c i e n t i s t w i l l b e expected, w i t h i n t h r e e y e a r s of j o i n i n g t h e c e n t e r , t o o b t a i n independent r e sea rch support from sources o t h e r than t h e c e n t e r g r a n t , I n t h i s way, t h e c e n t e r may cont inue t o provide support f o r o t h e r s c i e n t i s t s who e n t e r t h e c e n t e r program. Support f o r research-r e l a t e d c o s t s of p a t i e n t involvement and medical care may b e authorized. The program cannot provide funds f o r new cons t ruc t ion . For t h i s f i r s t compet i t ion f o r p e r i o d o n t a l d i s e a s e c l i n i c a l r e sea rch c e n t e r s , t h e I n s t i t u t e w i l l r e s e r v e funds t o i n i t i a t e one o r two c e n t e r s during FY 77. There w i l l b e a l i m i t e d expansion of t h e centers program during t h e next few yea r s . The expected range of support should b e $150,000 - $200,000 f o r t h e f i r s t yea r w i th modest increases i n subsequent yea r s .

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-1.J

NIH Guide f o r Grants and Contracts Vol . 5, No. 22, December 20, 1976 Page Five

Review Cr i te r ia Considerat ion f o r an award w i l l be based upon demonstrable evidence t h a t t h e a p p l i c a n t i n s t i t u t i o n can provide a combination of f a c t o r s inc luding:

1.

2.

3.

4 .

5.

6 .

Qual i ty research i n b a s i c microbiology, immunology, and/or pharmacology ;

Competent c l i n i c a l i n v e s t i g a t o r s ;

Mer i tor ious s c i e n t i f i c p r o j e c t s which re la te t o a common theme;

Appropriate p a t i e n t popula t ions ;

Adequate o u t p a t i e n t c l i n i c a l f a c i l i t i e s f o r c l i n i c a l r e sea rch ; and

A f avorab le environment f o r research t r a i n i n g .

The a p p l i c a t i o n s w i l l be reviewed by t h e Dental Research I n s t i t u t e s and Spec ia l Programs Advisory Committee (DRISPAC) of NIDR.

Let ter of I n t e n t I n o rde r t o f a c i l i t a t e planning f o r t h e review of appl ica­t i o n s , a " le t ter of i n t e n t " should f i r s t be submit ted by t h e sponsoring i n s t i t u t i o n . The l e t t e r of i n t e n t must d e a l b r i e f l y wi th each area s p e c i f i e d (3.a- i below) t o Se included i n t h e formal app l i ca t ion . Letter of i n t e n t should be addressed to : Chief , Per iodonta l Diseases Program Branch, Extra-mural Programs, Nat iona l I n s t i t u t e of Dental Research, Room 519, Westwood Building, Nat iona l I n s t i t u t e s of Heal th , Bethesda, Maryland 20014.

Appl ica t ion Process Appl ica t ions should be prepared on form PHS 398, "Applicat ion f o r Research Grant ,I' and should inc lude :

1. A t a b l e of contents;

2. A complete, consol ida ted f i r s t - y e a r budget f o r t h e e n t i r e c e n t e r (sumtar iz ing sub-budgets f o r t h e component p r o j e c t s and cores) ;

3. Expanded mrierial f o r each i t e m l i s t e d below:

a. Ra t iona le and j u s t i f i c a t i o n f o r t h e c e n t e r ,

b. A d e s c r i p t i o n of intended p r o j e c t s ,

c. A d e s c r i p t i o n of a v a i l a b l e l abora to ry f a c i l i t i e s ,

d. A d e s c r i p t i o n of ongoing b a s i c o r c l i n i c a l research r e l a t e d t o pe r iodon ta l d i sease ,

e. A d e s c r i p t i o n of a v a i l a b l e c l i n i c a l f a c i l i t i e s ,

-- Page S i x

f . S p e c i f i c information on p a t i e n t a v a i l a b i l i t y ,

g. A v a i l a b i l i t y of a s t a t i s t i c a l and d a t a a n a l y s i s c a p a b i l i t y ,

h. The academic p o s i t i o n s and major r e sea rch i n t e r e s t s of t h e program d i r e c t o r and h i s immediate s t a f f , and

i. Col l abora t ive p o s s i b i l i t i e s w i th o t h e r r e sea rch groups and d e l i n e a t i o n of t h e r o l e s and manner of a n t i c i p a t e d i n t e r a c t i o n .

Timetable f o r Review

A . Letter of i n t e n t due January 1, 1977.

B. Deadline f o r r e c e i p t of a p p l i c a t i o n s , February 15, 1977.

C. The ear l ies t beginning d a t e f o r award of g r a n t s , August 1, 1977.

The o r i g i n a l and s i x copies of the completed application should be mailed t o t h e Div i s ion of Research Grants , Na t iona l I n s t i t u t e s of Health, Bethesda, Maryland 20014. I n a d d i t i o n , i t w i l l b e h e l p f u l f o r i n fo rma t iona l purposes t o send two copies under s e p a r a t e cover t o t h e Chief , Pe r iodon ta l Diseases Program Branch, Extramural Programs, Na t iona l I n s t i t u t e of Dental Research, Room 519, Westwood Building, Na t iona l I n s t i t u t e s of Heal th , Bethesda, Maryland 20014.

NIH Guide f o r Grants and Cont rac ts Vol . 5, No. 22, December 20, 1976 Page Seven

W

REQUEST FOR RESEARCH GRANT APPLICATIONS: RFA A N N O U N C E M E N T I

TITLE: DIABETES I N PREGiVANCY: EFFECTS ON MOTHERS AND OFFSPRING

INTRODUCTION The Center f o r Research f o r Mothers and Children (CRMC) of t h e Nat ional I n s t i t u t e of Child Heal th and Human Development (NICHD) i n v i t e s a p p l i c a t i o n s f o r g r a n t s t o s tudy pregnancies a s s o c i a t e d wi th pre-diabetes m e l l i t u s , g e s t a t i o n a l d i a b e t e s , and o v e r t d i a b e t e s of e i t h e r t h e a d u l t o r youth-onset type and t o s tudy t h e o f f s p r i n g of d i a b e t i c pregnancies. There is p a r t i c u l a r i n t e r e s t i n feeding p a t t e r n s and developmental f a c t o r s r e l a t e d t o t h e la ter appearance of o b e s i t y and of d i a b e t e s i n t h e s e g e n e t i c a l l y predisposed i n d i v i d u a l s .

SCIENTIFIC PROGRAM REQUIREMENTS The CRMC seeks s t u d i e s aimed a t b u t n o t l i m i t e d t o understanding t h e pathophysiologic mechanisms which c o n t r i b u t e t o abnorma l i t i e s encountered i n t h e pregnant d i a b e t i c and h e r o f f s p r i n g . Research is encouraged on d e t e c t i o n of pre-diabetes i n t h e female populat ion of ch i ldbea r ing age. Funct ional d e f i n i t i o n of optimal d i a b e t i c c o n t r o l during pregnancy i s needed as w e l l as determinat ion of t h e opt imal t i m e and method of d e l i v e r y as r e l a t e d t o maternal and f e t a l s t a t u s , and t o t h e i n f a n t ' s a d a p t a t i o n t o e x t r a u t e r i n e l i f e and maintenance of homeostasis. I n v e s t i g a t i o n s are requested t o e x p l a i n t h e a b e r r a t i o n s i n embryogenesis a s s o c i a t e d wi th t h e i n t r a u t e r i n e environment i n d i a b e t i c pregnancies as w e l l as s t u d i e s focused on developing b e t t e r techniques t o d e t e c t f e t a l d i s t r e s s . S tud ie s should b e d i r e c t e d toward c l a r i f y i n g mechanisms r e spons ib l e f o r congen i t a l malformations, s t i l l b i r t h s , neona ta l d e a t h s , and p e r i n a t a l complications. Areas of p a r t i c u l a r i n t e r e s t i nc lude developmental s t u d i e s of intermediary metabolism and hormonal i n t e r a c t i o n s i n o f f s p r i n g of d i a b e t i c , g e s t a t i o n a l d i a b e t i c , and nond iabe t i c women. Also of i n t e r e s t are s t u d i e s on t h e impact of prepregnancy d i a b e t e s and g e s t a t i o n a l d i a b e t e s on t h e morphology, func t ion , and metabolism o� t h e p l a c e n t a and on u t e r i n e blood flow.

Prevent ion of d i a b e t e s m e l l i t u s i n g e n e t i c a l l y predisposed c h i l d r e n is a l s o a major concern. S tud ie s of childhood feeding p a t t e r n s and t h e development of d i e t a r y h a b i t s , tastes, and a p p e t i t e are r e l e v a n t , as are sea rches f o r o t h e r p r e s e n t l y unrecognized developmental antecedents of d i a b e t e s and obes i ty . The CRMC a l s o seeks s t u d i e s of i n f a n t s and c h i l d r e n born of d i a b e t i c women which emphasize t h e i r phys io log ic , anatomic, o r developmental aber­r a t i o n s . I n t e r e s t a l s o e x i s t s i n exp lo r ing t h e even tua l e f f e c t of t h e d i a b e t i c i n t r a u t e r i n e environment on growth and development of t h e o f f s p r i n g .

SIGNIFICANCE TO NICHD AND CRMC PROGRAM GOALS An important goa l of t h e CRMC is t o understand mechanisms underlying normal growth and development and t h e i r d i s t o r t i o n by t r a n s i e n t o r chronic even t s such as d i s e a s e o r f u n c t i o n a l d i s o r d e r i n t h e mother o r i n t h e f e t u s . Maternal (diabetes h a s had major e f f e c t s on p e r i n a t a l m o r t a l i t y , on t h e outcome of pregnancy, and on i n f a n t morbidity. This metabol ic d i s o r d e r may a l s o i n f l u e n c e d i e t a r y h a b i t s and somatic cond i t ions which could r e s u l t i n obes i ty . Developing new knowledge

Page E i g h t

about t h e complex processes by which maternal d i s e a s e o r dysfunct ion may a f f e c t t h e long-term h e a l t h of t h e mother, h e r r ep roduc t ive a b i l i t y , and t h e well-being of h e r o f f s p r i n g is a major concern of t h e Center f o r Research f o r Mothers and Children.

APPL I CAT I O N REQUIREMENTS

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E l i g i b i l i t y Nonprofit o rgan iza t ions and i n s t i t u t i o n s , S t a t e and l o c a l governments and t h e i r agenc ie s , au tho r i zed Fede ra l i n s t i t u t i o n s , and i n d i v i d u a l s according t o N I H g r a n t s p o l i c i e s .

The App l i ca t ion Applicants should propose an i n d i v i d u a l p r o j e c t . Applicants may e l a b o r a t e on t h e purposes, o b j e c t i v e s , r a t i o n a l e , and s i g n i f i c a n c e s t a t e d i n t h i s announcement and must complete p o r t i o n s of t h e a p p l i c a t i o n p e r t a i n i n g t o p rocedura l d e t a i l s , t h e i n v e s t i g a t o r ’ s r e l a t e d experience, f a c i l i t i e s a v a i l a b l e , budgets , and b i o g r a p h i c a l information f o r key p r o f e s s i o n a l personnel . The a p p l i c a t i o n should a l s o s t a t e t h e du ra t ion of t i m e f o r which t h e support i s requested. It is a n t i c i p a t e d t h a t t h e i n i t i a l pe r iod w i l l no t exceed t h r e e y e a r s b u t may b e renewable.

Submission U s e t h e s t anda rd r e sea rch g r a n t a p p l i c a t i o n form N I H 398. I n both t h e covering let ter -a t t h e top of t h e spaceand provided f o r an a b s t r a c t on page 2 of t h e a p p l i c a t i o n , c l e a r l y i d e n t i f y t h e a p p l i c a t i o n as b e i r g i n response t o t h i s announcement by us ing i t s t i t l e and d a t e of p u b l i c a t i o n .

Receipt Date App l i ca t ions should be submit ted t o m e e t t h e dead l ine d a t e s e s t a b l i s h e d by t h e Div i s ion of Research Grants, N I H , f o r new re sea rch p r o j e c t g r a n t a p p l i c a t i o n s .

REVIEW Upon r e c e i p t , a p p l i c a t i o n s w i l l b e revicved f o r responsiveness t o t h i s announcement by t h e Div i s ion of Research Gr;; . l+_s (DRG) i n c o n s u l t a t i o n wi th t h e NICHD s t a f f . Applicat ions judged responsiire w i l l b e reviewed i n i t i a l l y f o r s c i e n t i f i c merit by DRG s tudy sectioxls and secondly by t h e NACHHD Council. App l i ca t ions judged n o t responsive w i l l compete i n t h e r e g u l a r r e sea rch g r a n t program and w i l l be ass igned f o r a d m i n i s t r a t i o n t o an a p p r o p r i a t e I n s t i t u t e .

FUNDING Although t h i s program i s included and provi-ded f o r i n t h e f i n a n c i a l plans f o r f i s c a l yea r 1977, award of g r a n t s is cont ingent upon u l t i m a t e a l l o c a t i o n of appropr i a t ed funds f o r t h i s purpose.

NOTE For f u r t h e r information, p o t e n t i a l a p p l i c a n t s may con tac t :

D r . Joseph C . Hwang Center f o r Research f o r Mothers and Children Na t iona l I n s t i t u t e of Chi ld Heal th and

Human Development Bethesda, Maryland 20014

Telephone: (301) 496-1485 ’ I C ’

N I H Guide f o r Grants and Cont rac ts , Cumulative Contents (cont inued)

Volume No. 5

Guide No. 1, January 30, 1976

P r i v a c y A c t o f 1 9 7 4 . . . . . . . . . . . . . . . . . . . . . . . . . 1 Travel between U.S . and Canada, Chapter PHS: 1-510 . . . . . . . . . 2 Awarding of I n d i r e c t Costs f o r N I H Research Grants . . . . . . . . . 3

Guide No. 2 , A p r i l 1, 1976

Cancer Research Emphasis Grants . . . . . . . . . . . . . . . . . . . 1 N u t r i t i o n Research Grant Appl ica t ions Sought by

t h e Nat iona l I n s t i t u t e of Dental Research . . . . . . . . . . . . . 17 Spec ia l Dental Research Award . . . . . . . . . . . . . . . . . . . . 19

Guide No. 3. A m i 1 15. 1976

Receipt and Review Dates f o r Competing Appl ica t ions . . . . . . . . . 1 Notice of A v a i l a b i l i t y - Updated Guide l ines . . . . . . . . . . . . . 2 C l i n i c a l Cancer Education Grants . . . . . . . . . . . . . . . . . . 2 Request f o r Research Grant Appl ica t ions - NICHD . . . . . . . . . . . 5

Guide No. 4 , Apr i l 21, 1976

Descr ip t ions of N I H Col labora t ive Programs . . . . . . . . . . . . . 1

Guide No. 5, Apr i l 28, 1976

P r i v a c y A c t o f 1 9 7 4 . . . . . . . . . . . . . . . . . . . . . . . . . 1

Guide No. 6, May 28, 1976

Senior International Fellowships - FogartyI n t e r n a t i o n a l Center . . . . . . . . . . . . . . . . . . . . . . . 1

A v a i l a b i l i t y of Chimpanzees f o r H e p a t i t i s Research . . . . . . . . . 4 Research Support i n C e l l u l a r Aging -

National I n s t i t u t e on Aging . . . . . . . . . . . . . . . . . . . . 5 Spec ia l Research Awards - Nat iona l

I n s t i t u t e onAging . . . . . . . . . . . . . . . . . . . . . . . . 6 C l i n i c a l I n v e s t i g a t o r Award - National

I n s t i t u t e of A r t h r i t i s , Metabolism and Diges t ive Diseases . . . . . 7 N I H Research Career Development Awards . . . . . . . . . . . . . . . 8 Research Career Development Awards -

Nat iona l I n s t i t u t e o f General Medical Sciences . . . . . . . . . . 8 Reduction i n Reporting Requirements -

N I H Manpower Report (Form NIH-1749) . . . . . . . . . . . . . . . . 9

Guide No. 7. June 10. 1976

Freedom of Information A c t of 1974 (P.L. 93-502) . . . . . . . . . . 1

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NIH Guide for Grants and Contracts, Cumulative Contents (continued)

Guide No. 8 . June 25. 1976

Request for Applications - National Institute of Child Health and Human Development . . . . . . . . . . . . . . . . 1

Guide No. 9, July 2, 1976

National Research Service Awards f o r Individual Postdoctoral Fellows . . . . . . . . . . . . . . . . . . . . . . . 1

National Research Service Awards for Institutional Grants . . . . . . . . . . . . . . . . . . . . . . . 7

Guide No. 10, July 12, 1976

PHS Training Grant Application Forms, Research and Non-Research . . . . . . . . . . . . . . . . . . . . 1

Minority Hypertension Research Development Summer Program, Division of Heart and Vascular Diseases, National Heart and Lung Institute . . . . . . . . . . . . . . . . . . . . . . . . . .

Young Investigator Research Grant, National Heart and Lung Institute . . . . . . . . . . . . . . . . . . . . .

Pediatric Clinical Pharmacology Grant Applications Sought by the National Institute of General Medical Sciences . . .

Guide No. 11, July 16, 1976

Institutional National Research Service Awards -National Institute of General Medical Sciences . . . . . . . . . . 1

Individual Postdoctoral National Research Service Awards - National Institute of General Medical Sciences . . . . . 4

Guide No. 12, August 6, 1976

Minority Access to Research Careers (MARC Program) . . . . . . . . . 1 Request for Research Grant Applications -National Institute of Child Health and Human Development . . . . . 2

Digestive Diseases and Nutrition Centers . . . . . . . . . . . . . . 2 Guidelines for Program Project Grants - National Institute of Arthritis, Metabolism, and Digestive Diseases . . . . 3

Corrections: To Guides No. 9, 10, and 11 . . . . . . . . . . . . . 4 Revision: To Vol. 4 , No. 7, page 6, D (Cancer Control Program) . . 4

Guide No. 13 , August 20, 1976

Mass Spectrometry Facilities . . . . . . . . . . . . . . . . . . . . 1 Notice of Availability - National Stable Isotopes Resource . . . . . 2 Cancer Research Emphasis Grants . . . . . . . . . . . . . . . . . . 5

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N I H Guide f o r Grants and Contracts, Cumulative Contents (continued)

Guide No. 14, August 13, 1976

Nonhuman Primates Available . . . . . . . . . . . . . . . . . . . . . 1 Acquired Craniofacial Disfigurement Grant

Applications Sought by The National Irtst-iZute of Dental Research . . . . . . . . . . . . . . . . . . . . . . . . 2

Guide No. 15, September 15, 1976

P r io r Approval of U s e of N I H Grant Funds Including Rebudgeting . . . 1 Herpes Simplex Virus (HSV) - Research Grant

Applications Sought by The National I n s t i t u t e of Dental Research . . . . . . . . . . . . . . . . . . . . . . . . 11

Recurrent Aphthous S tomat i t i s (RAS) - Research Grant Applications Sought by The National I n s t i t u t e of Dental Research . . . . . . . . . . . . . . . . . . . . . . . . 12

Notice of Ava i l ab i l i t y of Nonhuman Primate Material f o r Research on Aging . . . . . . . . . . . . . . . . . . 13

Prohibited o r Restr ic ted Research . . . . . . . . . . . . . . . . . . 13 Special Grants f o r New Investigators i n

Anesthesiology - National I n s t i t u t e of General Medical Sciences . . . . . . . . . . . . . . . . . . . . . 1 4

Special Visual Sciences Research Awards -National Eye I n s t i t u t e . . . . . . . . . . . . . . . . . . . . . . 18

Minority Access t o Research Careers (MARC Program) Faculty Fellowships . . . . . . . . . . . . . . . . . . . . . . . . 19

Guide No. 16, September 2 4 , 1976

1976 Report on Personnel Needs and Training f o r Biomedical and Behavioral Research -Public Comment Invi ted . . . . . . . . . . . . . . . . . . . . . . 1

Treatment of Released Funds Resulting from Issuance of Research o r Academic Career Awards . . . . . . . . . . 2

Guide No. 17, September 13, 1976

Draft 'Environmental Impact Statement -Request f o r Comments . . . . . . . . . . . . . . . . . . . . . . . 1

Guide No. 18, October 8, 1976

Young Inves t iga tor Research Grant, National I n s t i t u t e of Allergy and Infec t ious Diseases . . . . . . . . . . . . . . . . 1

Diabetes Research and Training Centers, National I n s t i t u t e of A r t h r i t i s , Metabolism, and Digestive Diseases . . . . 6

Treatment of Released Funds Resulting from Issuance of Research Development o r Academic Career Awards . . . . . . . . . . 7

Application Assignment Information Mailed t o Business Offices . . . . . . . . . . . . . . . . . . . . . . . . . . 8

Extension of Application Receipt Date, Minority Hypertension Research Development Summer Program . . . . . . . . . 8

Prohibi ted o r Restr ic ted Research . . . . . . . . . . . . . . . . . . g

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N I H Guide f o r Grants arid Contracts . Cumulative Contents (continued)

Guide No . 19. November 15. 1976

Research Fellowships t o Sweden and Switzer land . . . . . . . . . . . 1 Senior I n t e r n a t i o n a l Fellowships . . . . . . . . . . . . . . . . . . 2 Notice of A v a i l a b i l i t y of I n t e r f e r o n . . . . . . . . . . . . . . . . 2 Nonhuman Primates Ava i l ab le . . . . . . . . . . . . . . . . . . . . 3 Submission and Acceptance of Revised Reports of Expenditures . . . . 4 Request f o r Research Grant Applicat ions: RFA . . . . . . . . . . . 7

Guide No . 20 . November 30 . 1976

DNA Recombinant Research . . . . . . . . . . . . . . . . . . . . . . 1 Programs of t h e Nat ional I n s t i t u t e of A r t h r i t i s .

Metabolism. and D i g e s t i v e Diseases Spec ia l i zed Centers of Research i n U r o l i t h i a s i s . . . . . . . . 4 C l i n i c a l I n v e s t i g a t o r Award. A r t h r i t i s . Bone. and Skin

Diseases Program . . . . . . . . . . . . . . . . . . . . . . . 6 Multipurpose A r t h r i t i s Centers . . . . . . . . . . . . . . . . . 8 Request f o r Research Grant App l i ca t ions .

S t u d i e s of Diabetes M e l l i t u s and Related Problems . . . . . . 9 S p e c i a l Dental Research Award . . . . . . . . . . . . . . . . . . . 15 Cancer Research Emphasis Grants (CREG)

Pa thophys io log ica l Mechanisms 'Involved i n t h e Formation of I n f r a r e d P a t t e r n s Emitted by Normal Sub jec t s and P a t i e n t s w i t h Benign and Malignant Tumors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17

E f f e c t s of New Anticancer Drugs on t h e C e l l Cycle . . . . . . . . 14 Research Teams f o r Antitumor Drug Development . . . . . . . . . . 21 Stud ies of Populat ions a t Low. Risk f o r Cancer . . . . . . . . . . 23 Mechanism of Action of New Anticancer Drugs . . . . . . . . . . . 25

Guide No . 21. December 1. 1976

Grant App l i ca t ions Sought by t h e Na t iona l Caries Program. Nat iona l I n s t i t u t e of Dental Research . . . . . . . . . . . . . . 1

Guide No . 22 . December 20 . 1976

Biomedical Research Development Grant Program . . . . . . . . . . . 1 Spec ia l i zed C l i n i c a l Research Centers

f o r Pe r iodon ta l Disease . . . . . . . . . . . . . . . . . . . . . 3 Request f o r Research Grant Applicat ions: RFA

Diabetes i n Pregnancy: E f f e c t s on Mothers and Of f sp r ing . . . . . 7

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