Akimoto, H ., 4658Alavaikko, M., 4486Al-Baker, S., 4567Albin, N ., 4608Anzano, M ., 4461Arai, H ., 4466Ardelt, B ., 4613Austin, E . A ., 4619Avila, M . A ., 4474

Bachelot, T., 4715Backstrom, T ., 4550Baselga, J., 4637Bast, A ., 4603Basu-Modak, S ., 4505Beems, D. B., 4603Benabid, A . L., 4715Berger, F . R ., 4715Berse, B., 4727Bhimani, R . S ., 4528Billingham, M . E., 4658Billstrom, A., 4573Bird, R. P ., 4499Bistocchi, M ., 4665Blanco, G ., 4486Blankenstein, M. A ., 4563Bleehen, N . M., 4680Block, N . L., 4493Bloom, L . B ., 4582Borgatti, P ., 4481Boyle, J. 0 ., 4477Brown, J. M., 4633Brown, L . F., 4727Brunet, J-F . M., 4715Bruno, N. A ., 4658Buttitta, F., 4665

Cabral, F ., 4573Callahan, R ., 4665Campani, D ., 4665Canaani, E ., 4489Cansado, J ., 4474Capitani, S ., 4481Carr, I., 4499Cavenee, W ., 4486Cecchetti, D ., 4665Chabot, G . G ., 4608Chang, C., 4648Chang, E . H ., 4452Chang, K-S., 4449Chen, S-H ., 4648Chen, T-H., 4720Clezardin, P ., 4695Cliby, W. A., 4456Coffey, D. S ., 4720Connolly, J . M., 4686Cork, A., 4449Correo, R., 4477Croce, C. M., 4489

Dahllof. B ., 4573Darzynkiewicz, R . J ., 4613Darzynkiewicz, Z ., 4613Dean, P . A ., 4652Debinski, W ., 4588de Frankrijker, E ., 4563de Jong, J ., 4603DeLacey, K. A ., 4456Delmas, P. D ., 4695Diella, F ., 4665Dodson, M. K ., 4456Dong, L., 4542

Donker, T . H ., 4563Donohue, J . H ., 4652Dorie, M . J ., 4633Dritschilo, A., 4474Drouin, J., 4695Du Vignaud, P., 4595Dvorak, H . F ., 4727

Eby, Y. J ., 4477Eto, S ., 4643

Fabbro, D ., 4542Fan, Z., 4637Felix, C . A ., 4489Fenton, W ., 4701Fernig, D. G., 4627FitzGerald, D. J ., 4588Freireich, E . J., 4449Frenkel, K ., 4528Fujii, N ., 4466Funa, K ., 4550Fuqua, S . A. W., 4443

Gibellini, D ., 4481Gong, J ., 4613Good, S. S ., 4619Goodman, M. F., 4582Gouyette, A., 4608Grand-Perret, T ., 4595Grizzle, W . E., 4555Grunberger, D ., 4528Grunenwald, D ., 4608Gunja-Smith, Z ., 4493Gustin, T., 4715

Hainaut, P ., 4469Hajnal, A ., 4670Hakim, J ., 4477Hanss, M ., 4695Hao, Z-M ., 4452Hard, G. C ., 4534Hartley-Asp, B ., 4573Hartmann, L. C ., 4456Hatala, M . A ., 4686Henriksen, R ., 4550Hertel, L . W., 4582Hilsenbeck, S . G., 4443Hruban, R . H ., 4477Hsu, H-C., 4691Hu, C-p ., 4648Huber, B . E ., 4619Hyafil, F., 4595

Iatropoulos, M . J ., 4534Imondi, A . R ., 4534

Jackman, R. W., 4727Jaken, S ., 4542Jenkins, R . B ., 4456Jordan, K ., 4534

Kadmon, D ., 4461Kaltenberg, O . P ., 4534Kaplan, C ., 4695Kapuscinski, J ., 4613Kasai, M., 4466Keeney, G . L., 4456Kehrel, B ., 4695Khazaeli, M . B ., 4555Khokhar, A . R ., 4567Kido, Y ., 4567Kiviniemi, H., 4486Klemenz, R ., 4670

AUTHOR INDEX

October 1, 1993

4739

Knick, V. C ., 4619Koch, W ., 4477Krajewski, S., 4701Kroin, J . S., 4582

Lai, P-L ., 4691Lange, B . J., 4489La Placa, M ., 4481Lawson, S ., 4555Lee, C-K., 4648Lee, M-S., 4449Lee, P-H ., 4691Lester, S . C., 4676Liu, T ., 4555LoBuglio, A. F., 4555Lokeshwar, B. L ., 4493

Madhuizen, H . T., 4603Magnuson, B. A ., 4499Mannermaa, A., 4486Manseau, E . J ., 4727Marchetti, A ., 4665Martin, C., 4489Maruyama, F., 4449Mashal, R . D., 4676Massaad, L., 4608Masui, H ., 4637Mazzoni, M ., 4481Mendelsohn, J ., 4637Meredith, R ., 4555Meyers, S. M., 4518Milani, D., 4481Milner, J., 4469Milton, J . D ., 4627Molin, L. F., 4715Morel-Kopp, M-C ., 4695Morgan, J ., 4680Mori, N., 4643Morizet, J ., 4608Murakami, S ., 4643

Nakamura, T., 4489Nakano, H., 4466Negrini, M ., 4489Nelson, H., 4652Newsham, 1 ., 4486Nortier, H . W. R ., 4563Notario, V., 4474

Oberg, K., 4550Oda, S., 4643Oesterreich, S., 4443Osborne, C . K., 4443Otero, G ., 4474

Pai, L . H ., 4588Parise, 0., Jr ., 4608Park, S . H., 4461Pastan, I ., 4588Pasternack, G . R., 4720Pellegrini, S ., 4665Peng, S-Y ., 4691Podratz, K. C ., 4456

Qiu, M ., 4443

Radi, L ., 4534Ramsey, P . S ., 4652Rayburn, J., 4686Reed, J . C ., 4701Reeve, J. G., 4680Rhodes, J. M., 4627Richards, C. A ., 4619

Richardson, F. C ., 4582Ridderheim, M., 4550Ritland, S . R., 4456Roa, R . A ., 4477Rorke, E. A., 4511Rose, D. P., 4686Ruppert, J . M ., 4477Russell, C ., 4555Saito, H., 4466Saleh, M . N ., 4555Scardino, P . T ., 4461Schafer, R ., 4670Schibler, M . J ., 4701Schlom, J., 4555Schwander, J., 4680Schy, W . E ., 4582Seed, T . M., 4518Selzer, M. G., 4493Senger, D. R ., 4727Serre, C-M ., 4695Shirakawa, F., 4643Siddik, Z. H ., 4567Sidransky, D ., 4477Sizemore, N ., 4511Sklar, J ., 4676Slate, D. L., 4658Slawin, K., 4461Smith, J . A., 4627Sporn, M . B ., 4461Srivastava, S ., 4452Stass, S . A ., 4449Stevens, J. L., 4542Su, J . Q ., 4456Takayama, S ., 4701Tanaka, S ., 4701Tasimowicz-Alpini, A., 4652Taskinen, P. J., 4486Thijssen, J . H . H ., 4563Thompson, T . C., 4461Tibbels, S., 4619Tognazzi, K ., 4727Tong, Y. A., 4452Torti, F. M., 4658Torti, S . V ., 4658Toussaint, C ., 4608Traganos, F ., 4613Troll, W., 4528Tseng, H-J ., 4691Tyrrell, R . M., 4505van Acker, S . A . B . E., 4603van der Riet, P., 4477van der Vijgh, W . J . F ., 4603van der Wall, E ., 4563Velasco, J. A ., 4474Vergely, C ., 4595Verna, J-M. G ., 4715Voest, E . E ., 4603Walensky, L. D., 4720Wang, Q-c ., 4588Wang, S., 4452Weng, C-N., 4443Wheeler, R . H., 4555Wilander, E., 4550Williams, G . M., 4534Winqvist, R., 4486Wu, T-C ., 4720Yang, P., 4449Yu, L., 4627Za li, G ., 4481

First Anno ncement

Call for Abstracts

85th Ann al Meeting of the

American Association for

Cancer Research

April 10-13, 1994

San Francisco, California

An Exciting M ltidisciplinary Program

That Links

Basic and Clinical Cancer Investigations

In This S pplement:

•

Abstract S bmission Forms•

Preliminary Scientific Program•

Information on Travel Awards for Yo ngBasic and Clinical Scientists

•

Advance Registration and Ho sing Forms•

AACR Membership Application Forms

TABLE OF CONTENTS

MEETING HIGHLIGHTS is

ACKNOWLEDGMENT CARD Following Page 2s

REGULATIONS APPLYING TO ABSTRACTS AND PROFFERED PAPERS3s

INSTRUCTIONS FOR PREPARATION AND MAILING OF ABSTRACTS4s

ABSTRACT CATEGORY/SUBCLASSIFICATION LIST 8s

SAMPLE ABSTRACT FORM 10s

OFFICIAL ABSTRACT FORMS 11s

MEMBERSHIP APPLICATION FORMSActive and Corresponding 15sAssociate 17s

ADVANCE REGISTRATION FORM 19s

HOTEL INFORMATION AND RESERVATION FORM 21s

TOPICS OF SPECIAL SESSIONS AT 1994 ANNUAL MEETING26s

HIGHLIGHTS

85TH ANNUAL MEETING OF THE AMERICAN ASSOCIATION FORCANCER RESEARCH (AACR)

APRIL 10-13,1994, SAN FRANCISCO, CA

THE ESSENTIAL INFORMATION RESOURCE FOR ALL CANCER RESEARCHERS

A TRADITION OF BROAD SCIENTIFICEXCELLENCE CONTINUES .

Beca se of its worldwide rep tation for comprehensivecancer programs at the basic, clinical, and translationallevels, the AACR Meeting is the event that all cancerresearchers cannot afford to miss .

• Internationally renowned basic and clinicalinvestigators will organize sessions on the mostpromising developments in the field .

Chairperson of the Program Committee, Karen S . H.Antman, Chief of the Division of Medical Oncology at theCol mbia Presbyterian Medical Center in New York, hasmade certain that the AACR Meeting will represent thef ll spectr m of the most timely and significant cancerresearch being cond cted today .

• This year's Program Committee has emphasized thoseareas that show promise for the translation of laboratoryfindings to the clinic .

• The Program Committee will organizem ltidisciplinary organ site sessions on topicss ch as breast, prostate, l ng, and pediatric cancers .

• Abstract categories have been revised to incl demore clinically relevant topics s ch as biologicaltherapy and radiation oncology, and othermodifications have been made to reflectcontemporary advances in cancer and biomedicalresearch .

• Scientific sessions will explore the importantclinical implications of new molec lar biologyfindings s ch as t mor s ppressor genes, apoptosis,and cell cycle control .

THE NEW MEETING FORMAT PROMOTESSCIENTIFIC INTERACTION AND REDUCESTRAVEL COSTS FOR PARTICIPANTS .

While maintaining excellence and breadth of scientificcoverage in the ann al meeting program, the format hasbeen modified s bstantially in order to red ce sched lingconflicts and travel costs, and to increase s bstantiallythe opport nities for slide presentations of profferedpapers in minisymposia . The AACR Meeting will

• Take place in April, well before the J ne 1 NIHgrant s bmission deadline and the Memorial DayHoliday .

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• Begin on S nday morning, April 10, and end onWednesday afternoon, April 13, allowing registrantsto obtain significantly red ced airfares that req ireSat rday night stayovers .

• Incl de fo r f ll days of scientific sessions . Morepapers will be presented in minisymposia . Also, it willbe possible to attend three-ho r symposia and still haveone ho r to view posters .

• Provide an opport nity to learn state-of-the-artresearch techniq es at methods workshops sched ledon Sat rday afternoon, April 9, the afternoon before theann al meeting officially begins .

• Feat re an opening plenary session and 26special symposia that incl de invitedpresentations by the leaders in the field .

• Present six major lect res covering reviews of state-of-the-art basic, clinical and translational cancerresearch .

• Offer opport nities for small-gro p interactionswith these leaders d ring an increased n mber of "Meetthe Expert" S nrise Sessions each morning as well assessions dealing with scientific controversies .

A FULL COMPLEMENT OF SERVICES ANDPROGRAMS MEETS YOUR OTHERPROFESSIONAL NEEDS.

• The rapidly growing exhibit show presents theprod cts and services essential to laboratory and clinicalresearch programs .

• The AACR Employment Register lists availablepositions and candidates and arranges appointmentsbetween employers and potential employees d ring themeeting .

• Women in Cancer Research (WICR) programsprovide g idance on career advancement for women inthe cancer field and offer insights to all cancerinvestigators .

• The Minority Iss es Committee's CareersSymposi m brings together senior and j niorinvestigators to disc ss pathways and obstacles tos ccessf l research careers in cancer and biomedicalresearch in vario s sectors .

• NCI Program Officers and St dy Section Leadersmeet informally with registrants and answer q estionsabo t the grant review process .

• The AACR Associate Member Meeting enablesyo ng investigators in the AACR to meet officers anddirectors and s ggest new Association programs to meettheir professional needs . (Nonmembers are welcome toattend .)

AN OUTSTANDING MEETING SITE IS NOWEVEN MORE APPEALING .

• The Moscone Center has added new meeting spacewhile remaining one of the most compact ven es thatcan accommodate the AACR Meeting .

•

The new San Francisco Marriott, only one block fromMoscone, will serve as headq arters hotel .

• A variety of other accommodations are available,incl ding economical properties, well-known l x ryhotels, and a n mber of San Francisco's famo s bo tiq ehotels .

• The Association's Official Travel Agent, Uniglobe, willoffer special airfare disco nts on United Airlines andDelta Air Lines. Call 800-243-4370 or (from o tside ofNorth America) 215-628-3322 or FAX 215-628-0310 .

•

Bonded child care will be available at the SanFrancisco Marriott Hotel.

•

Accompanying persons will have access to to rs ofseveral niq e local c lt ral and nat ral attractions .

AN EXPANDED PROGRAM OF TRAVELAWARDS MAKES IT EASIER FOR YOUNGINVESTIGATORS TO ATTEND THEMEETING.

• Upjohn Company and CIBA-Geigy Travel Awardsfor medical and grad ate st dents, physicians intraining, and postdoctoral fellows who are a thors ofabstracts that have been highly rated by the ProgramCommittee . Eligible scientists need only s bmit anabstract and check Box 6A on the abstract form fora tomatic consideration.

• Travel Awards from the Comprehensive MinorityBiomedical Program of the NCI for grad ate andmedical st dents, physicians in training, andpostdoctoral fellows from minority gro ps considerednderrepresented in cancer research by the NCI, i .e.

African Americans, Hispanic Americans, NativeAmericans, Native Pacific Islanders, and AlaskanAmericans . Check Box 6B on the abstract form or callthe AACR Office for an application form .

THE AACR MEETING IN SAN FRANCISCO, APRIL 10-13,1994THE MEETING YOU CANNOT AFFORD TO MISS

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• WICR St dent/Trainee Travel Awards for grad ateand medical st dents, physicians in training, andpostdoctoral fellows who have s bmitted an abstract forthe meeting and have been nominated by a member ingood standing of Women in Cancer Research. F rtherinformation will appear in the next anno ncement.

•

Other travel award programs will be anno ncedin f t re meeting broch res .

HOW TO PARTICIPATE

1 . S bmit an abstract . See official forms on Pages 11and 13, instr ctions on Pages 3-7, abstract categories onPages 8-9, and sample abstract on Page 10 . ABSTRACTDEADLINE IS OCTOBER 25, 1993 .

2 . Register for the meeting sing the advanceregistration form on Page 19 . Send the form withpayment by Febr ary 18, 1994, to obtain red cedregistration rates and to ens re the receipt of yo r badgeand meeting p blications in advance of the ann almeeting .

3 . Review the scientific program on yo r home oroffice comp ter in advance of the meeting byadding $15 to yo r advance registration fee payment .Check the appropriate box on the registration form andbe s re to specify the desired diskette format .

4 . Reserve a hotel room . On Page 23 yo will findthe official ho sing form ; on Page 21, instr ctions forsing the AACR Ho sing B rea in San Francisco and

a map showing the Moscone Center and all hotelsreserving rooms for the AACR Meeting ; on Page 22,sleeping room rates ; and on Pages 24-5, descriptions ofeach hotel . S bmit yo r form as soon as possible toobtain yo r first choice hotel room and, in any case, byMarch 9, 1994 .

5 . Join the AACR . Application forms for active andcorresponding membership appear on Pages 15-16, andfor associate membership, on Pages 17-18 . Applicationfor membership has been facilitated for many scientists :

• Corresponding members may now sponsorcandidates for corresponding, active, and associatemembership .

•

Eligible scientists from o tside of North Americamay now apply for associate membership .

• The next deadlines for applications for active andcorresponding membership are September 1, 1993,and Jan ary 1, 1994 . Applicants who meet theSeptember 1 deadline will be afforded theopport nity to sponsor an abstract for the 1994meeting pending their s bseq ent election tomembership .

AMERICAN ASSOCIATION FOR CANCER RESEARCH85th ANNUAL MEETING

Moscone Center • San Francisco, California • April 10-13, 1994

Deadline for Receipt of Abstracts at the AACR OfficeOCTOBER 25, 1993

Reg lations Applying to Abstracts and Proffered Papers

S bmission of an abstract of a paper forconsideration for presentation at the ann al meetingof the Association implies that the a thors have notprevio sly presented these data at a national scien-tific meeting and that they are not planning to do soprior to the dates of the AACR ann al meeting. Thecontent of all abstracts is kept confidential by themembers of the Program Committee d ring thereview and p blication process. After review of theabstract by the Program Committee the a thors willbe notified abo t its acceptability for presentation .The paper given at the ann al meeting m stcoincide directly with the scientific content of thes bmitted abstract . If for any reason this is notpossible, the paper m st be withdrawn frompresentation. Only those abstracts that afterscientific review by the Program Committee aredeemed acceptable for presentation at the ann almeeting will be p blished in the Proceedings of theAmerican Association for Cancer Research to beiss ed in the Spring of 1994 . N.B . A thors will becharged for prod ction costs of abstracts withdrawnafter the Proceedings goes to press .

The Program Committee will assign papers atits own discretion to minisymposia, poster disc ssionsessions, and poster sessions .

Minisymposia. Minisymposia will be plannedfrom s bmitted abstracts . This format serves as avehicle for the presentation and extensive disc ssionof developments in timely areas of cancer research .

A thors whose papers are assigned to mini-symposia will be informed abo t the amo nt of timeavailable for the delivery of their papers . There willbe opport nities for the disc ssion of each papersched led at appropriate intervals d ring thesession . In addition, these sessions will incl de anintrod ction and a concl ding disc ssion of the topic .

The Program Committee has identified an mber of topics as being s itable for minisymposiaand strongly enco rages the s bmission of abstractsin these areas . If a s fficient n mber of high-q alityabstracts are s bmitted and accepted on thesetopics, minisymposia will be devised . A thors whos bmit abstracts in these areas sho ld note thattheir papers may be sched led in poster sessions ifthey cannot be accommodated in minisymposia .A thors need not designate their interest in thesesessions on the abstract form ; the ProgramCommittee will se comp ter-aided searchtechniq es to identify appropriate s bmissions .

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SUGGESTED MINISYMPOSIUM TOPICSGenetic EpidemiologyHematopoietic Stem CellsNon-hematologic Stem CellsEarly International Dr g TrialsOncogenic Vir sesGene TherapyAngiogenesisBasic and Clinical Radiation ResearchCervical CancerGenetic InstabilityAIDS-associated MalignanciesNew Aspects of Dr g DesignNovel Chemical Str ct res in Dr g Development

Poster Disc ssion Sessions . Poster disc s-sion sessions will also be sched led from s bmittedabstracts and will r n for fo r ho rs . The s alpresentation of posters is s pplemented by afoc ssed disc ssion of the research areas nderconsideration. After presentation of posters, therewill be a one-ho r disc ssion period led by twochairpersons . Participants will have an opport nityto view the posters again after this disc ssion .

Prior to the ann al meeting, the twochairpersons of these sessions will comm nicatedirectly with the a thors presenting in the sessionto obtain more information on the work to be dis-c ssed. A thors will be expected to s bmit thecontent of their posters to the two chairpersons wellin advance of the meeting to maximize theeffectiveness of the disc ssion at the ann almeeting.

Poster Sessions. Reg lar poster sessions willextend for fo r ho rs. A thors will be req ired to bepresent at their posters for the first three ho rs ofeach session . Detailed instr ctions for thepreparation of posters will be sent to all a thorswhose abstracts are accepted for these sessions .

PRESENTERS PLEASE NOTE :If yo intend to present more than oneabstract, yo may find that the ProgramCommittee has inadvertently sched led thepapers in different sessions taking place atthe same time . Since time limitationsprecl de the resched ling of papers to othersessions, it will be the responsibility of thepresenting a thor to find a s itable coa thorto present the other paper(s) .

The Association will do its tmost to assist anya thor who, for religio s reasons, cannot present apaper on a partic lar day of the week. However, thecomplexities of sched ling tho sands of abstracts forthis m ltidisciplinary cancer research meetingreq ire that s fficient notice from a thors be givento the Program Committee. A thors who needspecial assistance in this regard m st enclose writ-ten req ests along with their s bmitted abstracts .

SPONSORSHIP REGULATIONS

1. The SPONSOR m st be a member of theAssociation in good standing . That is, an active,corresponding, or associate member m st have paidhis or her membership d es thro gh 1993 by thetime of the s bmission of the abstract in order toserve as the SPONSOR of one abstract for thepcoming ann al meeting . As stated in the AACRBy-Laws, honorary and emerit s members areexempt from the payment of d es; th s thisreg lation does not apply to them .

An associate member may SPONSOR his or herown abstract provided that (a) he or she is thePRESENTER of the abstract, and (b) an active orcorresponding member in good standing also signsthe abstract form endorsing the work. The endorserdoes not thereby lose his or her own sponsorshipprivilege . Note: An Associate Member may sponsoronly one (namely, his/her own) abstract .

2. Each member of the Association may sponsoronly one abstract . This privilege may be sed in oneof two ways: (a) the SPONSOR may be one of thea thors of the abstract, or (b) the SPONSOR maysign the abstract on behalf of the a thors who maybe members or nonmembers of the Association .

3. The SPONSOR m st sign the abstract formin the space provided .

4. A member or nonmember may be listed as acoa thor on more than one abstract, provided thateach abstract has a different member SPONSOR .

Instr ctions for the Preparation and Mailing of Abstracts

ABSTRACT FORM

Abstracts m st be s bmitted on the originalbl e and white abstract form provided by theAssociation . FAX TRANSMITTALS WILL NOTBE ACCEPTED.

Enclosed are TWO original abstract forms .Please pass one on to a colleag e if yo do not needit for yo r own abstract . Additional abstract formsmay be obtained by calling or by writing to theAssociation Office .

A Temporary Abstract N mber will be assignedto yo r abstract when it arrives at the AACR Office.The n mber will be listed on the card that isret rned to yo acknowledging receipt of yo rabstract. Please reference the Temporary Abstract

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5 . The SPONSOR is obligated to ascertain thatall a thors are aware of the content of the abstract .Sponsorship of an abstract implies s pport for thedata and interpretations contained therein .

Do not s bmit applications for 1993active/corresponding membership along withyo r abstracts . The closing date for receipt ofthese applications is September 1 .

COMPLIANCE WITH THESE REGU-LATIONS IS THE RESPONSIBILITYOF THE SPONSOR .Adherence to these r les will be verified .Violations will res lt in the rejection andret rn of the abstract to the SPONSORwitho t consideration by the ProgramCommittee .

ABSTRACT SUBMISSION FEE

A fee of US$35 will be assessed for each abstracts bmitted for consideration by the Program Com-mittee. This fee offsets some of the costs of process-ing the abstract. Each abstract m st be accom-panied by a check or p rchase order for US$35payable to the American Association for CancerResearch, Inc . - OR - a thorization m st be pro-vided to charge this fee to a credit card that isaccepted by the AACR (see Item 8 on the abstractform). All checks m st be drawn on United Statesbanks. If a p rchase order m st precede paymentby an instit tion, it is the PRESENTER'sresponsibility to ens re that the p rchase order isfollowed by payment of the fee . Please list thename(s) of the PRESENTER(s) on the check orp rchase order.

In cases of the vol ntary withdrawal of anabstract by the a thor, the ret rn of the abstractbeca se of violation of abstract reg lations, or therejection of the abstract for presentation, the s b-mission fee will not be ref nded .

N mber in all s bseq ent comm nications with theAACR Office .

The original abstract form m st be completelyfilled o t and signed in accordance with theinstr ctions. Two (2) photocopies of the completedform m st also be s bmitted. In addition to typingthe abstract within the bl e border according to theinstr ctions given below, please provide the infor-mation and signat res req ested on the abstractform as follows (N.B. The n mbered headings belowcorrespond to the n mbers on the abstract form .)

1 . Category and S bclassification. ChooseONLY one category and s bclassification. Indicatethe category and s bclassification in which yo rpaper belongs by typing the two-digit code of thes bclassification next to the appropriate category .

A list of codes for the categories and s bclassifi-cations appears on Pages 8-9 of this booklet. Thesedesignations will serve as a g ide to the ProgramCommittee in the gro ping of abstracts b t will notnecessarily be the act al titles of scientific sessionsto be held at the meeting .

2 . Sponsor of the Abstract . Type themember n mber, name, address, telephone n mber,and FAX n mber of the member sing his or hermembership privilege to SPONSOR the abstract .The SPONSOR, who m st be a member of the AACRin good standing thro gh 1993, may SPONSOR onlyone abstract. (See Page 4 for SponsorshipReg lations .)

3 . Sponsor Signat re. The SPONSOR m stsign the form in the space provided to indicates pport for the data and interpretations contained inthe abstract and to transfer the copyright of theabstract to the American Association for CancerResearch, Inc., copyright owner of the collectivework - the Proceedings of the American Associationfor Cancer Research.

4 . Associate Members Only. If the SPON-SOR AND PRESENTER is an associate member, heor she m st ask an active or corresponding memberin good standing or an emerit s or honorary memberto sign Line 4 of the form as an endorsement of thework. Type the name and member n mber of theendorsing member on the appropriate lines .

5 . Presenter of Abstract . Type the name,AACR member n mber (if applicable), address,telephone n mber, and FAX n mber of thePRESENTER of the paper in the space provided . Itis generally expected that the first a thor of anabstract will be its PRESENTER; however, theAssociation realizes that this person cannot alwaysbe present at the ann al meeting .

6 . Eligibility for Travel Awards .A. Indicate whether the PRESENTER of

the abstract is a medical st dent, grad ate st dent,physician in training, or postdoctoral fellow .PRESENTERS who meet these req irements andwho are first a thors on abstracts rated highly bythe Program Committee may be candidates for atravel award sponsored by the Upjohn Company orby CIBA-Geigy . If a PRESENTER is eligible basedon the above criteria and is nder consideration, aletter confirming his or her stat s on the officialletterhead of the PRESENTER's instit tion andsigned by the registrar, dean, or department head ofthat instit tion will be req ested at a later date .

B. If the PRESENTER meets the criteria inthe paragraph above, check this box if thePRESENTER is also Black, Hispanic, AmericanIndian, Native Alaskan, or Native Pacific Islander .The Comprehensive Minority Biomedical Program ofthe National Cancer Instit te f nds a program oftravel grants administered by the AACR toenco rage participation in the ann al meeting byminority gro ps which have traditionally beennderrepresented in cancer research .

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Eligible scientists are yo ng, f ll-timepredoctoral st dents, post-doctoral fellows, andphysicians in training who are either engaged incancer research, or who have training that co ldlead to contrib tions in this field. By action of theAACR Board of Directors, only citizens of the U .S .and Canada or scientists who are permanentresidents in those co ntries may receive one of theseawards. Awardees will be selected on the basis ofq alifications, references, and an estimation ofpotential benefit by an advisory committeeconsisting of members of AACR who will review acompleted application and letters of reference . Theaward will consist of partial s pport of registration,travel, and s bsistence expenses inc rred inconnection with attendance at one or both of theseann al meetings .

Persons checking this box will receive anapplication form which m st be completed andret rned to the AACR by Jan ary 10, 1994 .Applicants will be chosen from minority instit tionsas well as the larger bodies of niversities andresearch instit tions. Awardees are expected toattend at least three f ll days of scientific sessions .Along with their req ests for reimb rsement ofrelevant expenses, they m st s bmit a brief reportcommenting on the scientific sessions they attendedat the meeting(s) .

7 . Presenter Signat re. The PRESENTER ofthe paper m st sign the form in the space providedto give the Association permission to arrange fora diotape recording and the s bseq ent sale ofa diotape cassettes of the papers delivered orally atthe 1994 Ann al Meeting . Yo r advance permissionfor this taping in the event that yo r paper is amongthose to be recorded is appreciated . NOTE: If thePRESENTER is also the SPONSOR of the abstract,he or she m st sign the form on Line 3 as well asLine 7 .

8 . Optional A thorization to Charge CreditCard for US$35 Abstract S bmission Fee. Ifyo want the Abstract S bmission Fee (US$35) to bebilled to yo r credit card, please fill in the necessaryinformation and sign in the space provided .

ABSTRACTS SUBMITTED IN VIOLA-TION OF ANY OF THE ABOVE REGULA-TIONS, LE., ABSTRACTS WITHOUT ACATEGORY AND SUBCLASSIFICATION(LINE 1), WITHOUT THE NAMES OFTHE SPONSOR AND PRESENTER(LINES 2 AND 5), OR WITHOUT THE RE-QUIRED SIGNATURES (LINES 3 AND 7)WILL BE SUBJECT TO ANADMINISTRATIVE CHARGE OF US$35

CONTENT OF ABSTRACTS

As stated previo sly, s bmission of an abstractof a paper implies that the a thors have notprevio sly presented these data at a national

scientific meeting and that they are not planning todo so prior to the dates of the AACR ann almeeting .

Members of the Program Committee willeval ate the scientific q ality of the s bmittedabstract on the basis of several criteria : novelty ofthe research, significance of the findings, and theclarity of the presentation . A thors sho ld bepartic larly cognizant of the importance of settingforth the objectives and hypotheses of the st dy in aclear and s ccinct manner and of s mmarizing thenew, np blished res lts . If the abstract is poorlywritten s ch that the Program Committee cannotdetermine its novelty and importance, theacceptance of the paper for presentation at theann al meeting will be jeopardized .

1. Abstracts m st describe in a s ccinct mannerthe p rposes and res lts of the research so that theq ality, originality, and comprehensiveness of thework can be eval ated by the Program Committee .Each abstract sho ld contain : (a) an introd ctorysentence indicating the p rpose of the st dy; (b) abrief description of pertinent experimentalproced res; (c) a s mmary of the new, np blisheddata; and (d) a statement of the concl sions .A thors m st accept sole responsibility for thestatements in their abstracts . Abstracts sho ld becaref lly proofread to avoid errors in the p blishedliterat re .

2. Titles sho ld be indicative of the content ofthe abstract . All words necessary to identify thes bject matter sho ld be incl ded in the title tofacilitate information retrieval and online searches .Periods (not dashes or other p nct ation) sho ld besed to separate two-part titles . Abbreviations are

not permitted in titles .3 . Abbreviations may be sed in the body of

an abstract if they are defined at the first mentionin the text . Complex therape tic regimens m st beidentified. The chemical str ct re, method ofpreparation, and patent or reference n mber ofchemical compo nds sho ld be provided in the ab-stract .

4 . Ill strations within abstracts are not per-mitted; however, a brief, clear table is acceptable ifthe a thor(s) feel that this is the most effective modeof presenting the findings .

5. S pplementary data s bmitted along withthe abstract will not be accepted .

FORMAT OF ABSTRACTS

Abstracts will be printed in the Proceedings bydirect photoreprod ction of the original abstractform s bmitted by the a thor. Since errors made onthe form will appear in the p blished abstract,caref l preparation and proofreading are essential .Only abstracts s bmitted on the original abstractform will be considered by the Program Committee .There is a limited s pply of these forms. Therefore,before the abstract is typed on the final form, all

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instr ctions and the sample abstract sho ld be readthoro ghly .

Abstracts m st be prepared in accordance withthe approved format demonstrated in the sampleabstract (Page 10) . Please note in partic lar thefollowing reg lations concerning format :

1 . The entire abstract, incl ding text, title,a thors, and affiliations, m st fit within the bl elines provided .

2 . The abstract m st not be mechanicallyred ced to fit into the box provided .

3. The first line of the title sho ld be fl sh withthe left margin of the abstract box .

4. The heading m st incl de the title of thepaper with ONLY THE FIRST LETTER OF THEFIRST WORD CAPITALIZED and the rest in lowercase (except where lower case is incorrect - seesample), the a thors' names (as a gro p, with s r-names first and given names last), their instit tionalaffiliations, cities, states in abbreviated forms, zipcodes, and co ntries . If possible, please print thetitle in boldface letters .

Abbreviations are not permitted in titles .Abbreviations may be sed in the body of the ab-stract if they follow in parentheses immediatelyafter the term being abbreviated at the first sage ofthat term in the text.

5. Academic degrees sho ld be omitted .

6. The abstract sho ld be printed single spacedin one paragraph. Abstracts sho ld not be preparedon dot-matrix printers. Abstracts may be preparedon typewriters or daisy-wheel printers sing a sharpblack ribbon and a printing element no smaller than12 pitch (elite) . Abstracts may also be printed singlaser or ink jet printers with type no smaller than10 point .

7. Bl e ink will not reprod ce satisfactorily ;any symbols that m st be drawn by hand sho ld bedrawn in black ink .

ABSTRACTS OR ABSTRACT HEADINGSFOUND TO BE UNSUITABLE FOR DIRECTPHOTOREPRODUCTION WILL BE RETYPEDAT A COST OF US$35 TO THE SPONSOR .

PLEASE DIRECT QUESTIONS REGARD-ING THE PREPARATION OF ABSTRACTS TO215/440-9300.

SUBMISSION OF CORRECTED ABSTRACTS

If after mailing yo r abstract yo discover anerror, please s bmit a corrected abstract in strictaccordance with the following instr ctions :

1. Use an official abstract form, print the f ll textof the abstract in the space provided, and answer allq estions on the form .

2 . Write or type the word "Res bmission" in thebox in the pper right hand corner labeled Temp .Abst. No .

3 . Send the abstract to the address given on thenext page . In addition, write or type the word"Res bmission" on the mailing envelope .

A thors may be charged for the prod ction costsof abstracts res bmitted after the Proceedings iss ehas been sent to press . The Association will not beresponsible for the acceptance and processing ofrevised abstracts not s bmitted in compliance withthe above reg lations. No s bstantive changes maybe made in abstracts after they have ndergonescientific review, and the Association cannot acceptany res bmission that will delay p blication of theProceedings .

MAILING INSTRUCTIONS

1 . Abstracts m st be received in the office ofthe American Association for Cancer Research nolater than October 25, 1993. S bmission at anearlier date wo ld be appreciated . The Associationrges investigators working o tside of the United

States to mail their abstracts well ahead of thedeadline date or to se one of the internationalmailing services that offer delivery within a fewdays . The deadline for receipt m st be appliedniformly to all abstracts regardless of their origin .

2. The following material sho ld accompany theoriginal abstract form :

A. Two (2) legible, completed copies of theform .

B. A check or p rchase order for US$35payable to the American Association forCancer Research, Inc . All checks m st bedrawn on United States banks . PLEASELIST THE NAME(S) OF THEPRESENTER(S) ON YOUR CHECK ORPURCHASE ORDER. If yo wish s tocharge this amo nt to yo r credit card, fillo t and sign Item 8 on the abstract form .

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C . The Acknowledgment Card attached to thisanno ncement. The names of the a thors,and the title of the paper sho ld be filled inon the card prior to s bmission. The cardwill be ret rned to yo showing theTemporary Abstract N mber assigned toyo r abstract . This n mber sho ld bereferenced in all correspondence ortelephone calls to the AACR Office .PRESENTER: To ens re receipt of theAcknowledgment Card, p t yo r own ad-dress on the reverse of the card and affixproper postage .

D. One stamped, reg lar letter-sized envelope(abo t 4 x 9 1/2 inches, 10 .2 x 24.2 cm .)addressed to the PRESENTER . The finaldecision of the Program Committeeconcerning acceptability for presentationand p blication will be ret rned in thisenvelope along with any other necessaryinstr ctions .

3 . A check, p rchase order, or credit cardn mber in payment of US$35 . ; the original abstractform with the signat res of the SPONSOR andPRESENTER; 2 copies of the completed form; thecompleted, self-addressed, stamped AcknowledgmentCard; and one self-addressed, stamped envelopesho ld all be mailed nfolded and with cardboardbacking in an envelope of s itable size to :

Margaret Foti, Exec tive DirectorAmerican Association for Cancer Research, Inc .

P blic Ledger B ilding620 Chestn t Street, S ite 816Philadelphia, PA 19106-3483

4 . The envelope sho ld be marked"ABSTRACT FOR AACR ANNUAL MEETING."

5. Please note that special mailing chargescannot be paid by the AACR . The AACR staff can-not ass me responsibility for abstracts that are notdelivered directly to the premises . FAX transmittalswill not be accepted .

THE OCTOBER 25, 1993, DEADLINE WILL BE STRICTLY ENFORCED.