NEW ACADEMIC PROGRAM – IMPLEMENTATION REQUEST

I. PROGRAM NAME, DESCRIPTION AND CIP CODE

A. PROPOSED PROGRAM NAME AND DEGREE(S) TO BE OFFERED – Bachelor of Science in Pharmaceutical Sciences

B. CIP CODE – 51.2010 C. DEPARTMENT/UNIT AND COLLEGE

Department of Pharmacology & Toxicology College of Pharmacy

Campus and Location Offering – indicate by highlighting in yellow the campus(es) and location(s) where this program will be offered. UA South Campus UA Main UA Online Sierra Vista Tucson Online Douglas Phoenix Distance Campus Mesa Phoenix Biomedical Campus Chandler Santa Cruz Phoenix Paradise Valley Pima CC East UA Downtown UA Science and Tech Park

II. PURPOSE AND NATURE OF PROGRAM

The purpose of the BSPS Program is to educate undergraduate students in the pharmaceutical sciences. Students will take science courses in biology, chemistry, biochemistry, physiology, and pharmacology. In addition, students will take courses involving the use of scientific instruments, pharmaceutical methods of production, molecular biology, as well as the drug manufacturing process. Courses will include a combination of lecture-based and lecture plus laboratory-based courses with the primary intention of preparing graduates to work in a laboratory setting. These courses are intended to lay the foundation for entry level employment in the biotechnology industry. For clarification, this is not a professional degree program and completion of the BSPS degree will not qualify graduates to take the state board examination to become a registered pharmacist.

Phoenix area community college students will be the primary source of students for this program. In years 1 and 2 of the program, students will take science and general education courses at their local community college. For years 3 and 4, students will matriculate at the Paradise Valley Community College campus where upper division science courses will be offered by the University of Arizona. Paradise Valley Community College will serve as a distance learning site for the University of Arizona. At the completion of the course curriculum and during their last semester, students will be placed in internship positions located throughout the Phoenix area, where they will gain work experience. The proposed BSPS Program will be similar to programs offered at Purdue and Campbell Universities. For Purdue University, the BSPS curriculum serves as a feeder program for students wishing to enter pharmacy school in large part because the surrounding area lacks a base of pharmaceutical companies (personal communication with Holly Mason). In contrast, Campbell University is located within an hour of Research Triangle Park (RTP) in North Carolina. The RTP area is the location of many pharmaceutical companies and as a result, Campbell University graduates often enter the pharmaceutical industry (personal communication with Tim Marks). We expect that the University of Arizona BSPS graduates will be prepared for entry level positions in the pharmaceutical industry or academic preparation for admission into health sciences-related professional school such as pharmacy, medicine, dentistry, veterinary medicine or graduate school.

III. PROGRAM REQUIREMENTS

In order to hasten the education and training of students, the BSPS program will take advantage of the large cohort of students who are science majors in the Maricopa County Community College District (MCCCD) comprising 10 community colleges and 128,000 students in the Phoenix metropolitan area. The BSPS program will be a collaborative arrangement between the University of Arizona (UA) and MCCCD. Students will complete prerequisite courses during two years (Phase 1) at MCCCD campuses, and courses in the pharmaceutical sciences during a further two years (Phase 2) at the Paradise Valley Community College (PVCC) campus (part of MCCCD) directed and operated by the UA College of Pharmacy. This is referred to as a 2 + 2 program (Starting at Community College Can Save Thousands, Staff writer for U.S. News & World Report, May 18, 2011). Students enrolled in Phase 1 of the 2 + 2 BSPS program will take courses from accredited institutions with most students coming from MCCCD. However, students may enroll in Phase 2 of the BSPS program after completing prerequisite courses from other accredited institutions. Students will need to complete 52 units of core courses in their major (Appendix 1) and 12 units of elective courses to complete Phase 1.

Students enrolled in Phase 2 of the 2 + 2 BSPS program will take courses for three semesters taught by professors from the UA College of Pharmacy followed by a fourth semester that will require a working internships (14 units) with local biotechnology-based companies. In Phase 2 of the 2 + 2 BSPS program, students will enroll in 47 units of upper division courses. Since students will be working at internship sites in semester 8 (Appendix 1), they will need to complete their course work for Phase 2 in semesters 5-7. As a result, there will not be curricular space available for electives in Phase 2 of the program. In this regard, the 2 + 2 BSPS program will be much like the student teaching program in the College of Education where education students spend the last portion of their curriculum in the work environment (i.e., student teaching). Curriculum Summary Phase 1 52 units Units in major 12 units Electives Phase 2 47 units Upper division courses 14 units Required internship Total Units = 125 units

A. CURRENT COURSES AND EXISTING PROGRAMS

The majority of students will complete their prerequisite course work at the local community colleges within the Phoenix metropolitan area. However, it is expected that a few students may enroll into the BSPS Program after completing prerequisite courses from an accredited university or college. Regardless of the institution that students complete their prerequisites, they will need to ensure that the courses that they have taken will transfer to the University of Arizona. Appendix 1 lists the prerequisite courses offered by the University of Arizona and the equivalent courses offered at the Maricopa Community Colleges. In semesters 1 and 2, two courses [Molecules that Changed History (PCOL 189) and Pharmaceutical Science: From Bench to Bedside (PCOL 195A)] are currently offered at UA-Tucson and will be taught on the community college campus (PVCC) by UA faculty members. In Phase 2 of the 2 + 2 BSPS program, four courses are listed in the curriculum that are currently taught at the UA-Tucson campus [Experimental Design & Biostatistics (MATH 363), Introduction to Professional and Technical Writing (ENGL 313), Recombinant DNA Methods & Applications (MCB 473), and Introduction to Interpersonal Communication (COMM 114)]. Except for MCB 473, the remaining courses will be offered as either video conferenced or online courses. MCB 473 is a laboratory-based course and will be taught on the community college campus by UA professors, since the laboratory-based portion of the course cannot be taught online.

B. SPECIAL CONDITIONS FOR ADMISSION TO/DECLARATION OF THIS MAJOR Students will need to have completed or be enrolled in the prerequisite courses (Phase 1) listed in appendix 1 before they are accepted into the BSPS Program. Students will need to apply to the program and include the following information in their application:

(1) GPA 2.5 in program prerequisite courses (2) Official transcript(s) (3) List of current courses (4) Personal statement explaining how enrollment into the BSPS Program will

allow them to achieve their career goals (5) Two letters of recommendation from individuals qualified to assess the

applicants academic credentials

The application process will also involve an on-site interview to assess the applicants’ communication skills, moral and ethical characteristics, and motivation to pursue a career in the biotechnology field. If the number of applicants exceeds the number of available seats in the program, a waiting list will be created and applicants will be accepted using the earliest date of completed application as the deciding criteria.

C. NEW COURSES NEEDED

See Appendix 2. Some courses listed in Appendix 2 are available from UA-Tucson and would be taught online. Courses listed

D. REQUIREMENTS FOR ACCREDITATION There are no requirements for accreditation

IV. STUDENT LEARNING OUTCOMES AND ASSESSMENT

A. STUDENT OUTCOMES

Upon graduation, students will be able to:

a) apply knowledge of biology, chemistry, and mathematics. b) design and conduct experiments, as well as to analyze and interpret data. c) work independently in the laboratory. d) function on multidisciplinary teams. e) identify, formulate, and solve research problems. f) understand professional and ethical responsibility. g) communicate effectively.

h) use the broad education necessary to understand the impact of scientific research in a global, economic, environmental, and societal context.

i) recognize the need for, and an ability to engage in life‐long learning. j) demonstrate knowledge of contemporary issues in the field of pharmaceutical

sciences. k) use the techniques, skills, and modern tools necessary for the pharmaceutical

science industry.

B. STUDENT ASSESSMENT During the development and implementation of the BSPS Program, the college of pharmacy will name an Advisory Committee to oversee and advise the BSPS Program leadership. Student and course instructor input will be obtained in order to assess the program and individual courses. Students will be assessed on their ability to achieve the outcomes listed above. The Office of Instruction and Assessment at UA-Tucson will assist in the development of an assessment plan in order to obtain quantitative results of student progress through the program. The Advisory Committee will review and interpret data, making recommendations to leadership members for improvements. Additional student assessment will come from internship sites. Student performance at internship sites will be serve as a capstone assessment, helping identify strengths and deficiencies amongst the students. One important indicator will be the number of students who find permanent employment at their internship site. A high percentage of students employed at internship sites will be indicative of successful academic preparation that meets employer needs.

V. STATE'S NEED FOR THE PROGRAM

A. HOW DOES THIS PROGRAM FULFILL THE NEEDS OF THE STATE OF ARIZONA AND THE REGION? -- INCLUDE AN EXPLANATION OF THE PROCESS OR SOURCE FOR ARRIVING AT ALL NUMBERS USED IN THIS SECTION Arizona’s bioscience roadmap, a long-term strategic plan, was originally commissioned by the Flinn Foundation in 2002 and has been updated to meet the needs of the state for 2014-2025. The updated roadmap was compiled by the Battelle Technology Partnership Practice using input from Arizona leaders in science, business, academia, government, as well as bioscience experts. One of the vision statements from the report will be specifically addressed by the BSPS Program-“Build trees of talent by encouraging scientific, technical, and managerial talent to be developed and retained in the state.” One of the goals of the BSPS Program is to develop a local workforce that is ready for entry-level positions in the industry. The three state universities are already graduating individuals with doctoral degrees in

pharmacology, toxicology, and biochemistry to join the bioscience workforce, but there is a huge gap in entry-level training which this new program will address. The BSPS program proposed by UA is unique within the three public universities in Arizona. Regionally, the availability of current training is limited: the University of California-Irvine is the closest higher education institution with a pharmaceutical sciences program, while UC-Davis offers a biotechnology program focused mainly on plants and genetics. Key for the proposed 2 + 2 BSPS program from UA and MCCCD is its location within the Phoenix metropolitan area where biotechnology industries are growing and require graduates in the pharmaceutical sciences. For example in June 2016, Dexcom Inc. announced plans to expand its manufacturing of glucose monitoring devices into the greater Phoenix area, demonstrating workforce development needs in the region by adding 500 new jobs; while Celgene, a Fortune 500 company, already occupies a large manufacturing facility in Glendale, a Phoenix suburb.

1. IS THERE SUFFICIENT STUDENT DEMAND FOR THE PROGRAM? -- Since 2009, approximately 10,000 students per year transfer from the Maricopa County Community College District (MCCCD) to one of the three Arizona public universities. These students are data tracked by the Arizona State System for Information on Student Transfer (AZ Transfer ASSIST). It should be noted that students who majored in the Biological and Biomedical Sciences make up 8% of this transfer cohort, which translates into ~800 potential students to fill the 60 positions (per cohort) in the 2 + 2 BSPS program. Thus, the MCCCD campuses should readily provide the needed students for the BSPS program to reach capacity. It is also interesting to note that ~80% of students who transfer from MCCCD attend Arizona State University, indicating that the vast majority of these students prefer to stay in the Phoenix metropolitan area (Division of Academic and Student Affairs, MCCCD, 2011).

2. What is the anticipated student enrollment for this program? Since

many of the courses offered in the 2 + 2 BSPS program will involve a laboratory component, class size must be limited based on the physical size of the laboratory. PVCC will be the site of instruction for Phase 2 of the program and laboratories capacity is 20-24 students. As a result, laboratory-based courses will be offered where all students (60) will take the lecture portion of the course at the same time, while three laboratory sections will be convened with 20 students each. To make it easier for students to take the courses, it may be necessary to offer two different lecture times to offer students greater flexibility in their schedules.

5-YEAR PROJECTED ANNUAL ENROLLMENT

1st Year 2nd Year 3rd Year 4th Year 5th Year

Number of Majors

60 60 60 60 60

3. Within the State of Arizona, there are no other BSPS Programs.

Regionally, the University of California-Irvine has an undergraduate program in pharmaceutical sciences, and they boast that it is the only program of its kind in the UC system. Thus, the UA BSPS Program is unique to the State of Arizona.

With regard to job prospects for BSPS graduates, the Celgene pharmaceutical facility in Glendale, Pinnacle Transplant Technologies, and Dexcom have indicated that they would be interested in our graduates as well as interns immediately (personal communication). We believe that a reliable source of workforce-ready graduates will help entice other pharmaceutical corporations to locate in the Phoenix area, as well as other Arizona cities.

4. Beginning with the first year in which degrees will be awarded, what is the anticipated number of degrees that will be awarded each year for the first five years? (Please utilize the following tabular format).

PROJECTED DEGREES AWARDED ANNUALLY

1st Year 2nd Year 3rd Year 4th Year 5th Year

Number of Degrees

0 57 57 57 57

IV. APPROPRIATENESS FOR THE UNIVERSITY

The University of Arizona College of Pharmacy is the only school of pharmacy within the university system. Faculty members at the University of Arizona College of Pharmacy have the expertise needed to develop and teach courses in the BSPS Program. Configuring the BSPS Program as a 2 + 2 program, where students complete their prerequisite courses within the Maricopa Community College system will help make the program affordable to Arizona residents. The partnership with Maricopa Community College will also provide a relatively large pool of applicants for admission into the program. Since many of the courses offered by the University of Arizona will be laboratory-based courses, the number of students must be limited due to the availability of laboratory space at Paradise Valley Community College (site

where courses will be offered). The major driving force for selecting class size is the size of the laboratory. Typical laboratories at Paradise Valley Community College accommodate 20 students. As an example, class size could vary from 20-60 students, where all the students could attend the lecture but would attend different laboratory sessions due to a capacity of 20 students. Thus, if a class capacity is 60 students, three laboratory sessions would be needed. The College of Pharmacy strategic plan is to expand the professional school program into Phoenix. The first class of 24 pharmacy students has been admitted to matriculate at the Phoenix Biomedical Campus in the fall of 2016. Upon graduation, the BSPS program will help develop a larger pool of applicants for the pharmacy program.

V. EXISTING PROGRAMS WITHIN THE ARIZONA UNIVERSITY SYSTEM

A. Arizona University System -- List all programs with the same CIP code definition at

the same academic level (Bachelor's, Master's, Doctoral) currently offered in the Arizona University System. (Please utilize the following tabular format).

CIP

CODE1

PROGRAM

LOCATION

University & Site

PROGRAM ACCREDITATION?

YES/NO

1 None

2

Contact Pam Coonan (621-0950) coonan@email.arizona.edu for CIP Code information. Curricular Affairs (and the Graduate College for graduate programs) will determine if you are required to complete a comparison chart to discuss the ways in which the proposed program differs from University of Arizona programs. .

VI. EXPECTED FACULTY AND RESOURCE REQUIREMENTS

A. FACULTY

1. Current Faculty -- List the name, rank, highest degree, primary department and estimate of the level of involvement of all current faculty members who will participate in the program.

Director, BSPS Program Richard R. Vaillancourt/Associate Professor/Ph.D./Pharmacology & Toxicology/Direct and implement BSPS Program

2. Additional Faculty -- Describe the additional faculty needed during the next three years for the initiation of the program and list the anticipated schedule for addition of these faculty members.

It is important to emphasize that the BSPS Program will be a distance learning, undergraduate, 2 + 2 program housed within Paradise Valley Community College. Thus, the bulk of the course teaching will be performed by professors of practice who are hired to teach in Phoenix. The faculty members from the Department of Pharmacology & Toxicology who are housed in Tucson will have limited teaching responsibilities in the Phoenix-based BSPS Program. The Pharmacokinetics course, however, is intended to be taught online by Dr. John Murphy who is based in Tucson. The BSPS Program will require the development of 15 new courses and an internship program that will be taught in Phase 2, the two years of the University of Arizona portion of the 2 + 2 program. Based on this number of courses, four additional faculty members will be hired. In addition, although the courses are listed in a semester format (Appendix 1), the courses will be offered during the spring, summer, and fall sessions to provide student flexibility since many students who matriculate from the community college environment also maintain jobs while they attend school.

3. Current Student and Faculty FTEs -- Give the present numbers of Student

FTE (identify number by graduate and undergraduate students) and Faculty FTE in the department or unit in which the program will be offered.

The Department of Pharmacology & Toxicology has 16 faculty members and 33 graduate students. For undergraduate students, the courses are: “Molecules that Changed History”, PCOL 189 enroll 15 students; “Pharmaceutical Science: From Bench to Bedside”, PCOL 195A enroll 20 students; “The Chemical Environment, Environmental Exposures and Human Disease”, PCOL 395 enroll 11 students.

4. Projected Student and Faculty FTEs -- Give the proposed numbers of

Student FTE and Faculty FTE for the next three years in the department or unit in which the program will be offered.

For years 1-3, 60 new students are projected to enter the program in each year of the BSPS Program. With an anticipated retention rate of 95% in year 1 (100% retention is assumed for year 2), that will yield 57 students moving on to year 2 (60 + 57 = 117 students for yrs 1 & 2). In year 3 of the program, 60 new students will enroll (117 students in yrs 1 & 2 + 60 new students in yr 3 = 177). Thus, the program will have taught 177 students during the 3 year enrollment period. The BSPS Program will be an undergraduate program and will employ “professors of practice” and not tenure-track faculty members largely to keep costs down. There is no comparable undergraduate program at UA-Tucson. In addition, the facilities at Paradise Valley Community College will not include laboratory space for faculty members to conduct their own research. Thus, it is not practical to consider tenure-track positions for this program. As such, faculty members will be expected to maintain a full-time teaching load. For the next three years, the faculty FTEs will be 5 (BSPS Director + 4 faculty members).

B. LIBRARY

1. Acquisitions Needed

The PVCC library would hold textbooks on reserve so that students who cannot afford textbooks would have access to them. However at this point, the name any of the textbooks cannot be provided, since it will be up to the instructors to make those selections. As a University of Arizona distance learning program, students in the BSPS Program will have access to journal articles via online access. Thus, it is likely that very few, if any, new library acquisitions will be needed for the program.

C. PHYSICAL FACILITIES AND EQUIPMENT

1. Existing Physical Facilities -- Assess the adequacy of the existing physical facilities and equipment available to the proposed program. Include special classrooms, laboratories, physical equipment, computer facilities, etc.

The BSPS Program will not require special classrooms. However, laboratory space will be needed at PVCC to accommodate the laboratory-based courses. Space has been identified at PVCC. The laboratories at PVCC are currently arranged in units to seat 20-24 students. It is estimated that 3 laboratory units will be needed for the

BSPS Program where different courses within the program can alternate use of the laboratories. Since the BSPS Program falls under the category of Distance Learning at the University of Arizona, arrangements for new space will be handled in conjunction with Joel Hauff, Senior Vice President for Student Affairs and Enrollment Management.

2. Additional Facilities Required or Anticipated -- Describe physical facilities and equipment that will be required or are anticipated during the next three years for the proposed program.

The need for additional facilities is not anticipated. The PVCC campus has the infrastructure in place to handle student-related services like internet and library access, meals, fitness center, and parking. Purchase of laboratory equipment will be a major expense as the program is established. Efforts will be made to contact existing pharmaceutical companies for equipment donations. As an example, Eli Lilly Corp. has a donation program but a request was denied since they restrict donations to institutions within the State of Indiana. In order to help keep costs down, it is likely that used equipment will be purchased when possible. In addition, it may be necessary to visit a campus with an existing BSPS program to more accurately assess the laboratory equipment needs of our program. Tim Marks at Campbell University in North Carolina has made such an offer when I spoke with him on the phone. A Department of Labor grant, America’s Promise Job Driven Grant Program (FOA-ETA-16-12), was submitted on September 25, 2016 to help support implementation of the BSPS Program. The budget requested funds for two support staff members: one person as Academic Advisor and pre-admission coordinator and one Director of Internships. Additional funds ($210,400) were requested to purchase laboratory equipment and supplies for the laboratory-based science courses in the BSPS curriculum. Funds from the College of Pharmacy and the Vice President for Health Sciences will be provided should the Department of Labor grant not succeed.

D. OTHER SUPPORT

1. Other Support Currently Available -- Include support staff, university and non-university assistance.

Once the BSPS Program is approved, a marketing campaign will be initiated by Joel Hauff’s office, Senior Vice President for Student Affairs and Enrollment Management. It will be important to announce the BSPS Program to prospective students have time to prepare their applications. For example, they will need to complete their prerequisite courses and plan accordingly. In addition, the advertisements will provide information on when and where to apply.

2. Other Support Needed, Next Three Years -- List additional staff needed

and other assistance needed for the next three years.

As stated above, two support staff members will be hired: one person as Academic Advisor and pre-admission coordinator and one Director of Internships.

VII. FINANCING

A. SUPPORTING FUNDS FROM OUTSIDE SOURCES --List.

The Office of the Senior Vice President for Health Sciences will provide funding and the Dean of the College of Pharmacy.

B. BUDGET PROJECTIONS FORM -- Complete the budget projections form describing

the current departmental budget and estimating additional costs for the first three years of operation for the proposed program. Please note that these costs for each year are incremental costs, not cumulative costs. Include in this budget the anticipated costs for support for instruction, administration of the program, graduate students, marketing, the support discussed in Section VI-D.2, and any other costs that will be needed.

As a new program, the BSPS program will require the development of new courses as outlined in Appendix 1. As such, salary support of $100,000 is proposed for Professors of Practice to development the new courses and, if necessary, accompanying laboratory components. Obviously, some of the 1-2 unit courses will require less effort to prepare than some of the 4 unit laboratory-based courses. In year 1, three Professors of Practice will be hired to deliver the year 3 curriculum of the BSPS program. Meanwhile, the year 4

curriculum (1 semester) will need to be developed and one additional Professor of Practice will be hired to assist in the development of the new courses. In order to create flexibility within the curriculum, it is anticipated that courses will be offered during the spring and fall semesters, as well as a summer session. With 60 students enrolled per year, 3 laboratory sessions will be needed for the laboratory based courses. The Professors of Practice will lead the laboratory sessions. Although Paradise Valley Community College has laboratory facilities available to rent, the UA will need to purchase equipment and supplies for the laboratories. Funds are allocated for each year for new equipment (200K in year 1, and 100K/year in subsequent years) as the program develops and expands. As a reminder, year 1 will only have one cohort of students and all subsequent years will have two cohorts. In terms of revenue, student tuition will be the only source of revenue. A 95% retention rate is calculated thus leaving 57 of the year 1 cohort (60) for year 2. As a distance learning program of the UA, 30% of revenue will be returned to the UA which will pay for infrastructure support (internet, library, student services) and advertising costs associated with marketing the BSPS program.

VIII. OTHER RELEVANT INFORMATION

IX. REQUIRED SIGNATURES: Managing Unit Administrator: Richard Vaillancourt, Associate Professor

Managing Administrator’s

Signature:

_________________________________________ Date: September 14, 2016

Managing Unit Administrator: ____________________________________________________________________ (name and title)

Managing Administrator’s Signature: _________________________________________ Date:

Managing Unit Administrator: ____________________________________________________________________ (name and title)

Managing Administrator’s Signature: _________________________________________ Date:

Dean’s Signature: ________________________________________________ Date: September 15, 2016

Dean’s Signature: ________________________________________________ Date:

All programs that will be offered through distance learning must include the following signature. The

signature of approval does not indicate a commitment to invest in this program. Any potential investment

agreement is a separate process.

Joel Hauff, Associate Vice President of Student Affairs & Enrollment Management/Academic Initiatives and

Student Success

Signature: ________________________________________________ Date:

All programs that will be offered fully online must include the following signature: The signature of approval

does not indicate a commitment to invest in this program. Any potential investment agreement is a separate

process.

Vincent Del Casino Jr., Vice Provost for Digital Learning and Associate Vice President of Student Affairs &

Enrollment Management

Signature: ________________________________________________ Date:

Note: In some situations signatures of more than one unit head and/or college dean may be required.

Richard R. Vaillancourt

Associate Professor

Department of Pharmacology and Toxicology

College of Pharmacy, University of Arizona

Tucson, Arizona 85721-0207

E-mail: vaillancourt@pharmacy.arizona.edu, Phone: 520 626-4374

EDUCATION

1992 PhD, University of Wisconsin-Madison

1984 BA, St. Anselm College, Manchester, NH

EMPLOYMENT

2002 – present Associate Professor of Pharmacology & Toxicology with tenure,

University of Arizona College of Pharmacy, Tucson, AZ

1996 – 2002 Assistant Professor of Pharmacology & Toxicology, University of

Arizona College of Pharmacy, Tucson, AZ

1992 – 1996 Postdoctoral Fellow, Program in Signal Transduction, Division of Basic Sciences,

National Jewish Medical and Research Center, Denver, CO

Advisor: Gary L. Johnson, Ph.D.

1986 – 1992 Research Assistant, Department of Pharmacology, College of Medicine, University of

Wisconsin-Madison

Advisor: Arnold E. Ruoho, Ph.D.

1984 – 1985 Laboratory Technician, Center for Drugs and Biologics-Food and Drug Administration,

Bethesda, Maryland

Advisor: Kenneth B. Seamon, Ph.D.

1983 Student Internship, National Institute of Arthritis, Diabetes, Digestive, and Kidney

Diseases-National Institutes of Health, Bethesda, Maryland, Advisor: Kenneth B.

Seamon, Ph.D.

UofA AFFILIATIONS

2014 – 2016 Faculty Senate

2013 – present Cancer Biology Graduate Program

2004 – present BIO5 Institute, The University of Arizona Institute for Collaborative Research

1997 – present Arizona Cancer Center member

HONORS AND AWARDS

2016 Basic Science Educator of the year, College of Pharmacy

2015 – 2016 Academic Research Fellow, American Association of Colleges of Pharmacy

2012 Excellence in Teaching Award voted by the College of Pharmacy Graduate Students

2001 – 2002 Scientist Involvement Advisory Board, for the Environmental Health Sciences Training

and Education Program, of the Southwest Environmental Health Sciences Center,

Community Outreach & Education Program

2001 – 2005 Editorial Board, Toxicology Letters

2000 – present Editorial Board, Toxicology and Applied Pharmacology

1993 – 1996 NIH Postdoctoral Fellowship, NRSA

1992 – 1993 Fellowship from the Cancer League of Colorado

1991 – 1992 Advanced Predoctoral Fellowship in Pharmacology/Toxicology-Pharmaceutical

Manufacturers Association Foundation

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PROFESSIONAL MEMBERSHIPS

2000 – present Society of Toxicology and Mountain West Regional Chapter of the Society of

Toxicology, Councilor from 2000 – 2003

Vice President in 2006, President in 2007, Past President in 2008

1997 – Present American Association of Colleges of Pharmacy

EDITORIAL DUTIES

Editorial Advisory Board, Toxicology and Applied Pharmacology, 2000 – present

Editorial Advisory Board, Toxicology Letters, 2001 – 2005

Ad Hoc Reviews: Journal of Proteome Research, Journal of Biological Chemistry, Journal of Cellular

Physiology, Molecular Pharmacology, Critical Reviews in Oncology/Hematology,

Oncogene, Life Sciences, Carcinogenesis, Cell Death and Differentiation, Toxicology

Letters, Cell Biology and Toxicology, American Journal of Pathology, Experimental Cell

Research, Chemical Research in Toxicology, Circulation Research, Cellular &

Molecular Life Sciences, PLOS One

TEACHING RESPONSIBILITIES Fundamentals of Pharmacology (PCOL 871a, 4 units, 1997 – present, course coordinator 1997 & 1998)

Fundamentals of Pharmacology (PCOL 871c, 3 units, teach & course coordinator 2002 – present)

Cellular Communications and Signal Transduction (PCOL 630a, 3 units, 2005 – present)

Cellular Communications and Signal Transduction (PCOL 630b, 3 units, 2005 – present, course

coordinator 2005 - 2007)

Medicines: From Bench to Bedside (PCOL 195a, 2012 – present, colloquium for students in the Arizona

Assurance Scholars Program.

Advanced Toxicology (PCOL 596C, 2004 - 2009)

Medicinal Chemistry and Pharmacognosy (PCOL 437a, 1999)

Molecular Biology of Pharmacological Agents (PCOL 551, 1997-2004)

Bioethics for Biomedical Researchers (PHCL 595b, 2007 – 2015)

Principles of Pharmacology (PCOL 620, 1997-2002)

Case Studies in Pharmacology/Physiology (PCOL 820/821, 1996-present)

Molecular and Cellular Toxicology (TOX 610, 2001-2004)

Drugs of Abuse (PCOL 545)

Pharmaceutical Science Journal Club (PHSC 596G, 2003 – 2011)

GRADUATE EDUCATION

Post-doctoral fellows: 6

Graduate students: 7

Undergraduate students: 18

Graduate student committees: 9 M.S. students

Graduate student committees: 59 Ph.D. students

SELECTED PUBLICATIONS

1. Seamon, K.B., Vaillancourt, R.R., Edwards, M. and J.W. Daly (1984). Binding of [3H]forskolin to rat

brain membranes. Proc. Natl. Acad. Sci. USA 81:5081-5085.

2. Seamon, K.B., Vaillancourt, R.R. and J.W. Daly (1985). Modulation of forskolin binding to rat brain

membranes. J. Cyclic Nucleotide and Prot. Phos. Res. 10:535-549.

3. Vaillancourt, R.R., Dhanasekaran, N., Johnson, G.L. and A.E. Ruoho (1990). 2-Azido-[32P]NAD+, a

photoactivatable probe for G protein structure: Evidence for holotransducin oligomers in which the ADP-

Page 3 of 3

ribosylated carboxyl terminus of interacts with both and subunits. Proc. Natl. Acad. Sci. USA

87:3645-3649.

4. Derbyshire, Z.E., Halfter, U.M., Heimark, R.L. and R.R. Vaillancourt (2005). Angiotensin II stimulated

transcription of cyclooxygenase II is regulated by a novel kinase cascade involving Pyk2, MEKK4, and

annexin II. Mol. Cell. Biochem 271:77-90.

5. Halfter, U.M., Derbyshire, Z.E. and R.R. Vaillancourt (2005). Interferon-dependent tyrosine

phosphorylation of MEKK4 via Pyk2 is regulated by annexin II and SHP2 in keratinocytes. Biochem. J.

388:17-28.

6. Abell, A.N., Rivera-Perez, J.A., Cuevas, B.D., Uhlik, M.T. Sather, S., Johnson, N.L., Minton, S.K.,

Lauder, J.M., Winter-Vann, A.M., Nakamura, K., Magnuson, T., Vaillancourt, R.R., Heasley, L.E. and

G.L. Johnson (2005). Ablation of MEKK4 kinase activity causes neurulation and skeletal patterning

defects in the mouse embryo. Mol. Cell. Biol. 25:8948-8959.

7. Fritz, A., Brayer, K.J., McCormick, N., Adams, D.G., Wadzinski, B.E. and R.R. Vaillancourt (2006).

Phosphorylation of serine 526 is required for MEKK3 and association with 14-3-3 blocks

dephosphorylation. J. Biol. Chem. 281: 6236-45.

8. Pysher, M.D., Sollome, J.J., Regan, S., Cardinal, T.R., Hoying, J.B., Brooks, H.L., and R.R. Vaillancourt

(2007). Increased hexokinase II expression in the renal glomerulus of mice in response to arsenic.

Toxicol. Appl. Pharm. 224:39-48.

9. Pysher, M.D., Chen M.Q., and R.R. Vaillancourt (2008). Arsenic alters vascular smooth muscle focal

adhesion complexes leading to activation of FAK and Src-mediated pathways. Toxicol. Appl. Pharm.

231: 135-141.

10. Craig, E. Stevens, M.V., Vaillancourt, R.R., and T.D. Camensich (2008). MAP3-Kinase effectors as

central regulators of cell fate during development. Develop. Dyn. 237:3102-3114.

11. Stevens, M.V., Broka, D.M., Parker, P., Rogowitz, E., Vaillancourt, R.R. and T.D. Camenisch (2008).

MEKK3 Initiates Transforming Growth Factor 2-Dependent Epithelial-to-Mesenchymal Transformation

during Endocardial Cushion Morphogenesis. Circ. Res., 103:1430-1440.

12. Druwe, I.L. and R.R. Vaillancourt (2010). Influence of Arsenate and Arsenite on Signal Transduction

Pathways, An Update. Arch. Tox. 84:585-596.

13. Craig, E.A., Austin, A.F., Vaillancourt, R.R., Barnet, J.V., and T.D. Camenisch (2010). TGF2-

Mediated Production of Hyaluronan is Important for the Induction of Epicardial Cell Differentiation and

Invasion. Exp. Cell Res. 316:3397-3405.

14. Druwe, I.L., Hardwick, R., Sanchez Soira, P., Camenisch, T.D. and R.R. Vaillancourt (2012). Arsenite

Activates NF-B Through Induction of C-Reactive Protein. Toxicol. Appl. Pharm. 261:263-70.

15. Druwe, I.L. and R.R. Vaillancourt (2012). Arsenic and Signal Transduction (book chapter). The

tentative book title is Arsenic: Exposure Sources, Health Risks and Mechanisms of Toxicity.

16. Sollome, J.J., Thavathiru, E., Camensich, T.D. and R.R. Vaillancourt (2013). HER2/HER3 Regulates

Extracellular Acidification and Cell Migration through MTK1 (MEKK4). Cell Signal. 26:70-82.Lake,

A.D., Novak, P., Shipkova, P., Aranibar, N., Robertson, D.G., Reily, M.D., Lehman-McKeeman, L.D.,

Vaillancourt, R.R., and Cherrington, N.J. (2015). Branched chain amino acid metabolism profiles in

progressive human nonalcoholic fatty liver disease. Amino acids 47, 603-615

PATENTS

MTK1-Actin inhibitors and methods of use: US Patent Application No. 61/862,888. Filed August 6, 2013.

Inventors: R.R. Vaillancourt and J.J. Sollome.

Arizona Transfer Pathways Memorandum of Agreement Addendum Page 1 of 4

Appendix 1 Arizona Transfer Admissions Pathway

Bachelor of Science—Pharmaceutical Sciences 2017-2018

To qualify for the Pharmaceutical Sciences Transfer Admissions Pathway, a Maricopa Community College student enrolled in the Associate of Science program must:

Submit an undergraduate application for admission form to University of Arizona during the university’s application filing period for acceptance, at least one semester in advance of transfer, and otherwise qualify for admission.

Students who do not earn a grade of B or better in 2nd semester English Composition must also satisfy a college or department writing requirement.

Satisfy second semester foreign language requirement ***

Satisfactorily complete all Maricopa Community College graduation requirements for the Associate of Science prior to the date the student intends to transfer to the university; otherwise, transcripts will be evaluated on a course-by-course basis. Students must complete Literacy (L), Cultural (C) and Global or Historical (G or H) requirements as part of the AGEC as well as MCCD Communication and Reading requirements. For efficiency in degree completion, it is recommended that students meet these requirements by selecting applicable general education and elective courses within the pathway below.

Check the current UA Schedule of Classes to confirm course availability and class prerequisites because the Pharmaceutical Sciences core courses may have prerequisite requirements and may not be offered in both Fall and Spring semesters at the University.

University of Arizona Maricopa Community Colleges

SEMESTER ONE

Course Title Course Number Units SUN #* Course Number Units

First Year Composition ENGL 101 3 ENG 1101 ENG 101 3

Calculus I MATH 122B 4 MAT 2220 MAT 220 or 221 3-4

Introductory Biology I & Lab MCB 181R & MCB 181L

4 BIO 1181 BIO 181 4

General Chemistry I CHEM 151

3 CHM 1151

[CHM 151 & 151LL] or

[CHM 150 & 151LL] or

[CHM 150AA] or

[CHM151AA]

4-5

Molecules that Changed History PCOL 189 2 UA ONLY 2

16 16-18

SEMESTER TWO

Course Title Course Number Units SUN #* Course Number Units

First Year Composition ENGL 102 3 ENG 1102 ENG 102 3

General Chemistry II CHEM 152 3 CHM 1152 CHM 152 & CHM 152LL

or CHM152AA 4

Introductory Biology II & Lab ECOL 182R & ECOL 182L

4 BIO 1182 BIO 182 4

General Education/Social & Behavioral Sciences

INDV 1XX 3 Satisfied by AGEC** 3

Pharmaceutical Science: From Bench to Bedside

PCOL 195A 1 UA ONLY 1

14 15

Arizona Transfer Pathways Memorandum of Agreement Addendum Page 2 of 4

SEMESTER THREE

Course Title Course Number Units SUN #* Course Number Units

Organic Chemistry I CHEM 243A & CHEM 241A

4 CHM 2235 CHM 235 & CHM 235LL 4

General Education/Humanities TRAD 1XX 3 Satisfied by AGEC** 3

General Physics I PHYS 181 & PHYS 102

4 PHY 1111 PHY 111 4

Anatomy & Physiology I PSIO 201 4 BIO 2201 BIO 201 4

General Education/Humanities TRAD 1XX 3 Satisfied by AGEC** 3

18 18

SEMESTER FOUR

Course Title Course Number Units SUN #* Course Number Units

Organic Chemistry II CHEM 243B & CHEM 241B

4 CHM 2236 CHM 236 & CHM 236LL 4

General Education/ Social & Behavioral Sciences

INDV 1XX 3 Satisfied by AGEC** 3

Microbiology & Lab MIC 205A & MIC 205L

4 BIO 2205 BIO 205 4

Anatomy & Physiology II PSIO 202 4 BIO 2202 BIO 202 4

15 15

SEMESTER FIVE

Course Title Course Number Units SUN #* Course Number Units

Biochemistry CHEM Elective 4 CHM 260 CHM 260 & CHM 260LL 4

Exper. Design & Biostats MATH 363 3

Pharmaceutical Calculations PCOL 3XX 2

Laboratory Safety PCOL 3XX 1

Intro. Pharm & Toxicol. PCOL 3XX 3

Intro Prof. & Tech. Writing ENGL 313 (online)

3

16

Arizona Transfer Pathways Memorandum of Agreement Addendum Page 3 of 4

SEMESTER SIX

Course Title Course Number Units Course Number Units

Industrial Pharmaceutics PCOL 3XX 4

Recombinant DNA Methods & Applications

MCB 473 4

Product/Process Validation PCOL 3XX 2

Basic Pharmacokinetics PCOL 3XX (online)

2

Pathophys. & Drug Act. PCOL 3XX 3

15

SEMESTER SEVEN

Course Title Course Number Units Course Number Units

Analytic Instrumentation PCOL 4XX 4

Pharm. Meth. & Bioprocess. PCOL 4XX 4

Clinical Biochemistry PCOL 4XX 3

Intro. Interpersonal Comm. COMM 114 (online)

3

Sci. Lit. Seminar PCOL 4XX 1

Drug Develop. & Regulation PCOL 4XX 1

15

SEMESTER EIGHT

Course Title Course Number Units Course Number Units

Independent Study/Internship PCOL 4XX 14

Senior Seminar PCOL 4XX 1

15

*SUN numbered courses are “Shared Unique Numbers” across Arizona community colleges and universities that have equivalents at least three Arizona community colleges and all three state universities. For more information, visit http://aztransfer.com/aztransfer/sun/index.html.

Appendix 2

Courses offered by the College of Pharmacy

Catalog (lecture/lab units) Title Description

MATH 363 (3) Experimental Design & Biostatistics

Statistical analyses to the design, conduct, and interpretation of experimental research.

PCOL 3XX (2) Pharmaceutical Calculations Pharmaceutical calculations pertinent to the selection, formulation, preparation, dosage and administration of drugs and their dosage forms.

PCOL 3XX (1) Laboratory Safety This course will introduce students to topics related to chemical, biological, and radiation safety.

PCOL 3XX (3) Introduction to Pharmacology & Toxicology

Introduction to basic principles of structure activity relationships along with biochemical pharmacology emphasizing physicochemical properties of functional groups, metabolism, receptor theory, signal transduction, and drug absorption, distribution, metabolism, and excretion.

ENG 313 (1) Scientific & Technical Writing This course will enable students to effectively and accurately write and review technical documents used in the pharmaceutical and related-industries.

PCOL 3XX (3/1) Industrial Pharmaceutics This course will provide hands-on experience in the pre-formulation and manufacturing of pharmaceutical dosage forms.

MCB 473 (3/1) Recombinant DNA Methods & Applications

Fundamental principles of recombinant DNA technology. The course will provide a basic understanding of the techniques used in biotechnology with laboratory training.

PCOL 3XX (2) Product & Process Validation Introduction to the principles of good manufacturing practices, quality control, and quality assurance. Students will learn about facility validation, equipment, cleaning procedures, and processes. Discussion of the need for thorough documentation of manufacturing activities.

PCOL 3XX (2) Basic Pharmacokinetics This course offers an understanding of basic and clinically applicable pharmacokinetic principles and the assumptions involved with their use in drug monitoring.

PCOL 3XX (2/1) Pathophysiology & Drug Action The study of structural and functional changes in cells, tissues, and organs.

PCOL 4XX (3/1) Analytical Instrumentation Introductory course studying the theory and operation of scientific instrumentation found in the pharmaceutical, chemical, and biotechnical research industries.

PCOL 4XX (3/1) Pharmaceutical Methodology & Bioprocessing

This course will study how to use living cells to produce pharmaceutical agents. Area of study will include growth of cell lines, isolation of proteins produced in the cells, and analytical techniques used to identify, quantify, determine purity of proteins.

PCOL 4XX (3) Clinical biochemistry This course will discuss the principles of quantitative analysis used in standard clinical laboratory tests. The regulatory effects of drugs and hormones will be discussed.

COMM 114 (3) Introduction to Interpersonal Communication

Written and verbal communication skills will be developed to help students efficiently manage meetings. Techniques will be taught to help students effectively mentor and manage employees, with a focus on gender and cultural differences.

PCOL 4XX (1) Scientific Literature Seminar Students will be introduced to the literature to develop critical thinking skills

PCOL 4XX (1) Drug Development & Regulation This course will discuss regulations imposed by the Food and Drug Administration and the Environmental Protection Agency.

PCOL 4XX (14) Independent Study/Internship Students will be placed within industry or academic laboratories to train in the conduct of pharmaceutical production or experimental research.

PCOL 4XX (1) Senior Seminar This seminar course will guide and assist students in the writing of their senior project.

UA Equivalencies Campbell University Purdue University Program Name Bachelor of Science in

Pharmaceutical Sciences Bachelor of Science in

Pharmaceutical Sciences Bachelor of Science in

Pharmaceutical Sciences

Currently enrolled students none 100 120

Focus

Starting framework

Methodological Approaches

Exemplary Question

Sample Course Target Careers 33% of students enter pharm.

industry, 33% enter graduate school, 33% enter professional school

80% of students enter pharm. industry, 20% enter professional school or Master’s in Pharm. Science

33% of students enter pharm. industry, 33% enter graduate school, 33% enter professional school

Total Units 125 129.5-131.5 120

Upper -division Units

Foundation courses

English Composition ENGL 101 & ENGL 102, Composition I & II

ENGL 101, Academic Writing

ENGL 10600, 1st yr comp.

Foreign Language none LANG 201, Foreign Language

none

Math MATH 122B, Calculus I MATH 122, Calculus I MA 16010, Appl. Calc. I MA 16020, Appl. Calc. II

Tier 1 GE Requirements

INDV Two 150 level courses THEA 115, Public Speaking COM 11400, Fund. Speech Communication

NATS *Satisfied by major prerequisites. CHEM 151, Gen. Chem. I CHEM 152, Gen. Chem. II

Satisfied by major prerequisites.

Satisfied by major prerequisites.

TRAD Two 160 level courses HST 1XX, Western Civilization I or II

Science, Technology & Society Selective Elective

Tier 2 GE Requirements

Arts One T2 Arts course A/M/T-Art/Music/Theatre Elective

Humanities One T2 Humanities course Humanities/Social Science Selective

INDV COMM 114, Introduction to Interpersonal Communication

ECON 200, Economics Elective

NATS *Satisfied by major prerequisites.

Satisfied by major prerequisites

*Satisfied by major prerequisites.

Diversity Emphasis COMM 114, Introduction to Interpersonal Communication

UNIV XXX, Humanities/Social Science Elective

Can be satisfied in Human Cultures Core

# of Units required in major

102 98.5 98-99

# of Upper-division Units required in the major

61 51.5 40

Supporting Coursework to be Completed Prior to Admission and/or Declaration of the Major

MCB 181R & MCB 181L, Introductory Biology I ECOL 182R & ECOL 182L, Introductory Biology II CHEM 151, General Chemistry I CHEM 152, General Chemistry II CHEM 243A & CHEM 241A, Organic Chem. I & lab CHEM 243B & CHEM 241B, Organic Chem. II & lab

BIOL 111/111L, Basic Biology CHEM 111/111L, General Chemistry. I CHEM 113/113L, General Chemistry II CHEM 227/227L, Organic Chemistry & lab CHEM 228/228L, Organic Chemistry II & lab

BIOL 11000, Fund. Biol. I BIOL 11100, Fund. Biol. II CHM 12901, Gen. Chem. CHM 37200, Phys. Chem.

MIC 205A & MIC 205L, General Microbiology & lab PSIO 201, Human Anatomy & Physiology I PSIO 202, Human Anatomy & Physiology II PHYS 102 & PHYS 181, Intro. Physics & lab ENGL 313, Intro. Prof. & Tech. Writing

BIOL 334/334L, Microbiology & Immunology and lab BIOL 221/221L, Human anatomy & Physiology and lab PHYS 221, General Physics PHSC 451, Scientific & Technical Writing

BIOL 22100, Microbiology BIOL 30100, Anat. Physio I BIOL 30200, Anat. Physio II PHYS 22000, Physics ENGL 42100, Tech. Writing

Introductory 1stlevelCore Courses in the Major

PCOL 189, Molecules that Changed History PCOL 195A, Pharmaceutical Science: From Bench to Bedside

PHAR 100, Freshman Seminar

IPPH 10000, Pharm. Sci. Orientation

2nd level Core Courses in the Major

Biochemistry 3XX, elective PHSC 323, Biochemistry PHSC 325/325L, Biochemistry

MCMP 20400, Org. Chem I MCMP 20500, Org. Chem II

Research Methods, Data Analysis, and Methodology Requirements

MATH 363, Intro Statistical Methods

MATH 160, Statistics PHSC 324, Intro Biostatistics

STAT 30100, Statistics

Internship, Practicum, Applied Course Requirements. (Yes/no. If yes, please describe.)

Yes, internship required. Students will work at a partner facility (corporation, research or gov’t institution, university) for the semester.

Yes, internship required after completion of all course work.

No

Senior Thesis or Senior Project Required (Yes/No)

Yes No No

Additional Requirements (Please Describe.)

None

# of Elective Units in the Major.

0 21-22

Minor (Optional or Required)

Optional No

Expenditure Items

Initial Base Budget

Annual Incremental Costs

Year 1 2017-2018

Year 2 2018-2019

Year 3 2019-2020

Professor of Practice

100,000 Build 10 courses

303,075 (3 x 75K + ERE)

404,100 (4 x 75K + ERE)

404,100 (4 x 75K + ERE)

Other Personnel 134,700 (2 x 50K + ERE)

134,700 (2 x 50K + ERE)

134,700 (2 x 50K + ERE)

Graduate Assistantships

Operations 25,000 50,000 50,000

Other Items

One Time Expenditures

25,000

Start-Up Equipment

200,000 100,000 100,000 100,000

Replacement Equipment

10,000 10,000

Library Resources

Totals

Grand Totals 325,000 562,775 698,800 698,800

Anticipated Review

Students Units/year Cost/unit Tuition

Revenue

COP Revenue (70%)

Distance Learning

Costs

Year 1 60 30 $500 $900,000 $630,000 $270,000

Year 2 117 30 $500 $1,755,000 $1,228,500 $526,500

Year 3 117 30 $500 $1,755,000 $1,228,500 $526,500