Neuroscience Books Oct. 2010

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Contents

Frontiers in Neuroscience Series........................3

Clinical Neuroscience ....................................13

Neuropsychology............................................15

Neuroscience ..................................................18

Lab Animal Science ........................................20

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Frontiers in Neuroscience Series

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New!

Advances in theNeuroscience ofAddictionEdited by

Cynthia M. KuhnDuke University Medical Center,Durham, North Carolina, USA

George F. KoobThe Scripps Research Institute, La Jolla, California, USA

Written by an international team of authorities intheir respective fields, this book provides anoverview of current and emerging approachesfor investigating the biologic mechanisms ofdrug addiction. Delineating promising researchdiscoveries in relapse prevention, it covers math-ematical models, model organisms, and tradi-tional, well-characterized animal models, andexperiments conducted on humans.The book begins with current animal models ofaddiction, which mimic the state of humansentering treatment—recently-abstinent animalsthat receive common triggers for relapse (classi-cal conditioning, stress, and neuroadaptive dys-regulation). Coverage then shifts to the use ofelectrophysiologic approaches, which enableresearchers to characterize the discharge pat-terns of single neurons during drug self-adminis-tration.

• Covers novel approaches for investigating the biologic mechanisms of drug addiction

• Explores advances in voltammetry andenzyme-linked biosensors for measuring glutamate

• Highlights promising research discoveries inrelapse prevention

The text discusses the theoretical backgroundand results of neuroimaging studies related toneuronal networks activated by drug-specificcues. It then describes modern geneticapproaches to manipulate target proteins thatinfluence addictive behavior. It rounds out itscoverage by illustrating how a neuroeconomicapproach can inform studies of reward process-ing in general and addiction in particular.

Catalog no. 7391, April 2010, 238 pp.ISBN: 978-0-8493-7391-6, $139.95 / £89.00

New!

Neurobiology of Huntington’sDiseaseApplications to Drug DiscoveryEdited by

Donald C. LoDuke University Medical Center, Durham, North Carolina, USA

Robert E. HughesBuck Institute for Age Research, Novato, California, USA

This volume presents a thorough review of theissues surrounding drug discovery and develop-ment for the treatment of Huntington’s disease(HD). Drawing on the expertise of keyresearchers in the field, the book discusses thebasic neurobiology of HD. It explains how themonogenic nature of the disease confers enor-mous practical advantages for translationalresearch, including the creation of robust exper-imental tools, models, and assays to facilitatediscovery, as well as validation of molecular tar-gets and drug candidates for HD.

• Covers the latest research approaches ingenetics, genomics, and proteomics—including high-throughput and high-contentscreening

• Highlights advances in the discovery anddevelopment of new drug therapies for neurodegenerative disorders

• Examines the practical realities of preclinicaltesting, clinical testing strategies, and, ultimately, clinical usage

While the development of effective drug treat-ments for this paradigmatic neurodegenerativedisease remains a big challenge, a highly inter-active and cooperative community ofresearchers and clinical investigators brings us tothe threshold of potential breakthroughs in thequest for therapeutic agents. The impressivearray of drug discovery resources outlined in thetext holds much promise for treating this diseaseand for providing hope to HD patients and theirfamilies.

Catalog no. 9000, July 2010, 338 pp.ISBN: 978-0-8493-9000-5, $149.95 / £95.00



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Advances inVagal AfferentNeurobiologyEdited by

Bradley J. UndemJohns Hopkins Asthma Center,Baltimore, Maryland, USA

Daniel WeinreichUniversity of Maryland,Baltimore, USA

"… well written … considers the most outstandingresearch in the vagal afferent neurobiology."

—Rosario Pasaro,Journal of Chemical Neuroanatomy, Vol. 37

From the terminals in visceral tissues to neuralpathways within the central nervous system, thistext considers all aspects of the vagal afferentsystem. It covers the development, neurochem-istry, anatomy, biophysics, pharmacology, andphysiology of the vagal afferent nerves. Theauthors present techniques for investigating thedevelopment, morphology, electrophysiology,and reflex function of the vagal afferent nerves.

Catalog no. 2131, 2005, 544 pp.ISBN: 978-0-8493-2131-3, $173.95 / £97.00

Bestseller!

Apoptosis inNeurobiologyEdited by

Yusuf A. HannunMedical University of SouthCarolina, Charleston, USA

Rose-Mary BoustanyDuke University Medical Center,Durham, North Carolina, USA

"… a nice introduction to the field … the editorand authors are to be commended for providing acoherent, although detailed overview…"

—Joseph A. Bobich,Texas Christian University, Fort Worth, USA

Concentrating on conceptual approaches, thisbook provides a user-friendly approach to meth-ods and techniques involved in the study ofapoptosis as applied to neurobiology. It coversthe various methods used in the study and eval-uation of apoptosis—discussing the significance,utility, and interpretation of these methods andapproaches.


Animal Modelsof CognitiveImpairmentEdited by

Edward D. LevinDuke University Medical Center,Durham, North Carolina, USA

Jerry J. BuccafuscoMedical College of Georgia,Augusta, USA

Animal models of cognitive function, are criticalfor determining the neurobehavioral basis forcognition and for the development of new ther-apeutic treatments for cognitive impairment.Animal Models of Cognitive Impairment fea-tures an integrated approach that combinesmolecular and neurochemical approaches intranslational models with behavioral and clinicalapplications. The text also discusses research ongenetic, lesion, pharmacological toxicant, andaging models. The book then explores the sig-nificance of this research to the treatment of var-ious addictions and disorders such as stroke,autism, Alzheimer’s, schizophrenia, and ADHD.


Biology of theNMDA ReceptorEdited by

Antonius M.VanDongenDuke University Medical Center,Durham, North Carolina, USA

The NMDA receptor, a subclass of the ionotrop-ic glutamate receptor family, plays a critical rolein the development of the central nervous sys-tem and in adult neuroplasticity, learning, andmemory. This popular reference describes allimportance aspects of NMDA receptor biology.The text highlights exciting new discoveries thathave been made over the past decade. It pro-vides a comprehensive review of various molec-ular genetics studies that illustrate the impor-tance of this class of receptors; in addition, thebook presents a discussion of recent crystallo-graphic x-ray structures of its ligand bindingdomains.






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Brain AgingModels, Methods,and MechanismsEdited by

David R. RiddleWake Forest University, Winston-Salem, North Carolina, USA

This volume reviews critical studies of brainaging in animal models as well as advances inbrain imaging techniques that permit investiga-tions in aging humans with increasingly higherresolution. Detailed discussions link informationfrom human and animal studies to illustrate acomplete picture of the mechanism of aging.Emphasizing normal brain aging rather thanpathological degeneration, the text provides anunderstanding of fundamental age-relatedchanges in the nervous system and the hypoth-esis driven research into their basis. The bookincludes critical analyses of the distinct method-ological challenges inherent in investigating theaging nervous system.


Bestseller!

DNA ArraysTechnologies andExperimentalStrategiesEdited by

Elena V. GrigorenkoMillennium Pharmaceuticals,Inc., Cambridge, Massachusetts,

This bestselling resource offers a clear view of thedifferent aspects of this evolving technology,including oligonucleotide and electrochemicalarrays. Distinguished investigators provideinsights into methodological fundamentals forthe construction of DNA arrays. They cover opti-mization of hybridization conditions, the use ofexpression data in bioinformatics, software tools,and the application of microarray technology fordrug discovery.

• Includes detailed protocols for large scaleanalysis of gene expression

• Presents methods that are adaptable to various laboratory conditions

• Considers techniques involved in the usageof high density cDNA and oligonucleotidearrays


ComputationalNeuroscienceRealistic Modelingfor ExperimentalistsEdited by

Erik De SchutterUniversity of Antwerp-UIA,Wilrijk, Belgium

"Instead of merely repackaging their own scientificfindings, the authors focused on the methodology ofcreating computational implementations of concep-tual models of biological neurons and networks."

—N.T. Carnevale, Yale University, The Quarterly Review of Biology, Vol. 77, No. 2

What makes this resource unusual is the accom-panying CD-ROM that furnishes interactivemodeling examples. It contains tutorials, demos,movies, images, and scripts needed to run thefull simulations described in the examples.Addressing varying levels of complexity, thebook avoids theoretical mathematics and pro-vides only the basic math needed to understandexperiments.


Fat DetectionTaste, Texture, andPost Ingestive EffectsEdited by

Jean-Pierre MontmayeurCentre des Sciences du Hout,Dijon, France

Johannes le CoutreNestle Research Center,Lausanne, Switerland

Taking a multidisciplinary approach, this volumesheds new light on critical concerns regardingdietary fat and its relation to obesity. Delvingbeyond the well-known concerns, it offers new scientific data on the many aspects of fat, including psychological, behavioral, genetic, andphysiological factors that contribute to its desirability, perception, intake, and impact onhuman health. It includes information on geneticpredisposition, neural imaging, endocrine impactson metabolism, and also provides a progressiveintegrated view on fat taste, preference, and nutrition at the molecular level.

Catalog no. 67753, January 2010, 643 pp.ISBN: 978-1-4200-6775-0, $149.95 / £95.00







Functional andNeuralMechanisms ofInterval TimingEdited by

Warren H. MeckDuke University, Durham, North Carolina, USA

" … thorough and richly informative … invaluableand highly recommended."

— Journal of Clinical Psychiatry, Aug. 2005

"Never before has such a large array of phenome-na and methods been put together with such acoherent analysis."

—Robert Rousseau, Laval University, Quebec

Written by foremost experts, this book inte-grates the fields of quantum and psychophysics,rhythmic performance, and synchronizationthrough the linkage of time as information in thebrain and in behavior. It describes the basicmathematical and psychological aspects ofscalar timing theory and mode-control modelsof counting and timing.


Second Editionof a Bestseller!

Methods forNeuralEnsembleRecordingsSecond EditionEdited by

Miguel A. L. NicolelisDuke University Medical Center, Durham, North Carolina, USA

Extensively updated and expanded, this secondedition of a bestseller provides the nuts andbolts foundation of this rapidly growing science.With contributions from pioneering researchers,it includes microwire array design for chronicneural recordings, new surgical techniques forchronic implantation, microelectrode microstim-ulation of brain tissue, multielectrode recordingsthat occur in the somatosensory system and during learning, as well as recordings from thecentral gustatory-reward pathways. It exploresuse of the Brain-Machine Interface to restoreneurological function and proposes conceptualand technical approaches to human neuralensemble recordings in the future.


In Vivo OpticalImaging ofBrain FunctionSecond EditionEdited by

Ron D. FrostigUniversity of California, Irvine, USA

Following in the tradition of its popular prede-cessor, this second edition reaches across disci-plines to review a variety of noninvasive opticaltechniques for studying activity in the livingbrain. Leading authorities from diverse areassuch as optical hardware, cognitive behavior,and neuroscience present a host of perspectivesthat range from a single neuron to large assem-blies of neurons several million strong—cap-tured at various temporal and spatial resolutions.Introducing techniques that were unavailablejust a few years ago, the book describes theirtheory, setup, and analytical methods, as well asexamples that highlight the advantages of eachmethod.


Methods inAlcohol-RelatedNeuroscienceResearchEdited by

Yuan LiuNational Institute ofNeurological Disorders & Stroke,Bethesda, Maryland, USA

David M. LovingerLab. of Integrative Neuroscience, NIAAA, Nashville, Tennessee, USA

Written by a panel of experts, Methods inAlcohol-Related Neuroscience Research pro-vides an overview of the many areas involvedwith investigating the effects of alcohol on thebrain. It gives technical guidance for investiga-tors doing research at the molecular, cellular,systems, and behavioral levels. These techniquesinclude a variety of approaches, ranging fromgene mapping and examination of molecularinteractions of alcohol at the sub-cellular level torecording of neural activities in freely-behavinganimals and imaging alcohol effects on the liv-ing human brain.






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Methods inChemosensoryResearchEdited by

Sidney A. Simon &Miguel A. L. NicolelisDuke University Medical Center,Durham, North Carolina, USA

"… represents the kind of basic and well-writtenlaboratory manual and overview textbook longedfor in every field."

—Perceptual Motor Skills

Investigating all aspects of taste and olfaction,this popular reference describes molecular, elec-trophysiological, genetic, behavioral, psy-chophysical, and imaging techniques that havebeen adapted to investigate the basic neuronalmechanisms underlying chemoreception.


Methods inGenomicNeuroscienceEdited by

Hemin R. ChinNational Eye Institute/NIH,Bethesda, Maryland, USA

Steven O. MoldinUniversity of Southern California,Office of Research Advancement,Washington, DC, USA

"I recommend reading Methods in GenomicNeuroscience in its entirety - from start to finish,or from finish to start, or in any order. That is acompliment that one can rarely offer a book of themethods type."

—Nature Neuroscience

This book addresses tools and technologies forglobal analysis of genes influencing the nervoussystem and its disorders.


Methods inInsect SensoryNeuroscienceEdited by

Thomas A. ChristensenUniversity of Arizona, Tucson, USA“… a ready starting pointfor anyone interested induplicating particular tech-niques or applying them toother systems.”

—The Quarterly Review of Biology, Vol. 82, No. 1


Bestseller!Methods inPain ResearchEdited by

Lawrence KrugerUniversity of California, Los Angeles, USA

"… a well-written approach,the authors address differentpoints of pain research…The scope is broad butthe text, to-the-point. … an important book forneuroscience libraries and laboratories involved inthe study of pain. 4 stars!"

- Celso Agner, MSc, MD, Albany Medical Center, in Doody's Notes


Methods inDrug AbuseResearchCellular and Circuit Level AnalysesEdited by

Barry D. WaterhouseMCP-Hahnemann School ofMedicine, Philadelphia,Pennsylvania, USA

"… the text concise, the pictures of excellent quali-ty, and the graphs very handy. … an importantbook for any neuropsychiatry or neurologylibrary."

—Celso Agner, M.Sc., M.D., Albany Medical Center

This volume provides detailed descriptions ofprocedures, methods, equipment, and strategiesfor conducting experiments that investigate sys-tems level actions that occur with drug abuse.









Second Editionof a Bestseller!

Methods ofBehaviorAnalysis inNeuroscienceSecond EditionEdited by

Jerry J. BuccafuscoMedical College of Georgia, Augusta, USA

Details Step-By-Step Methodologiesthat are Easy-To-Reproduce

A comprehensive reference for commonly studied behavioral approaches in animal subjects,this book provides a better understanding of disease effects and therapeutic treatments. It features material on the relevance of transgenicmouse models for Alzheimer’s disease, behavioralmethods for assessing the cognitive impairmentassociated with major psychotic disorders, therevival of the scopolamine reversal model forassessing the clinical relevance of AD drugs, andapproaches for assessing cognitive impairment inaged mice. Each chapter presents theoreticalbackground, methodology, and data interpreta-tion.


Motor Cortex in VoluntaryMovementsA Distributed Systemfor DistributedFunctionsEdited by

Alexa RiehleINCM - CNRS, Marseille, France

Eilon VaadiaThe Hebrew University, Jerusalem, Israel

This book presents developments in motor cortex research that allow researchers to readand interpret neural activity and use the data to reconstruct movements. It focuses on howneuronal activity changes during learning, whatthe motor cortex encodes, and the neuronalrepresentations of voluntary movements and themechanism of their generation during learning.Along with its detailed coverage of advancedapproaches to motor cortex research, the bookalso includes early historical notes and briefdescriptions of classical studies of neuronal activ-ity in frontal sensorimotor fields.


ModernNeurosurgeryClinical Translationof NeuroscienceAdvancesEdited by

Dennis A. TurnerDuke University Medical Center,Durham, North Carolina, USA

Focusing on how an increased understanding ofbrain function affects clinical neuroscience, thisvolume explores the interface between non-clin-ical and clinical neuroscience advances by exam-ining the hypotheses that drive this evolution. Itreviews the relevant underpinnings of neurosur-gical techniques, treatments, and conceptualapproaches. A critical aspect of this rationalapproach is to underscore what needs to bedone in each field, potentially leading to furtherstudy and improvements.


NeuralPlasticity andMemoryFrom Genes to Brain ImagingEdited by

Federico Bermúdez-RattoniNational University of Mexico,Mexico City

Providing a multidisciplinary review of researchon the neurobiology of memory, this volumeexamines the synaptic communication elementsidentified as being susceptible to modificationthrough the accumulation of experience. Itexplains how cell circuitry is modulated and ulti-mately modified by neurotransmitters and hor-mones during the process of acquiring, consoli-dating, and retrieving information. In eachchapter, researchers present findings, whileexplaining their innovative methodologies. Thistext also addresses memory studies involvinghuman brain imaging.






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NeuralPlasticity inAdult SomaticSensory-MotorSystemsEdited by

Ford F. EbnerVanderbilt University,Nashville, Tennessee, USA

Synthesizing information about sensory-motorplasticity, this book describes the dynamicprocesses that occur in somatic sensory-motorcortical circuits or somatic sensory pathways tothe cortex due to experience, learning, or dam-age to the nervous system. It emphasizeschanges in the cortex that are linked to changesin movement or behavior—demonstrating thepotential for direct brain-based interventions toimprove the quality of life for people with sen-sory-motor disabilities. The book includes stud-ies that document the dynamic changes in sys-tem properties that occur with normal experi-ence or in recovery from brain damage.


NeuroproteomicsEdited by

Oscar AlzateUniversity of North Carolina,Chapel Hill, USA

“ … encapsulates some ofthe key areas in which pro-teomic technologies aremaking an impact in neuro-science.—Expert Review of Proteomics,

June 2010, Vol. 7, No. 3

With an extensive background in mathematicsand physics, Dr. Alzate exemplifies the newestgeneration of biological systems researchers. Heorganizes an overview of neuroproteomics thatis practical and progressive. Approaches dis-cussed include mass spectrometry, electrophore-sis, chromatography, surface plasmon reso-nance, protein arrays, immunoblotting, compu-tational proteomics, and molecular imaging.


NeuralProstheses forRestoration ofSensory andMotor FunctionEdited by

John K. ChapinState University of New YorkHealth Science Center,New York, USA

Karen A. MoxonDrexel University, Philadelphia, Pennsylvania, USA

While the creation of a "six million dollar man"may still be far into the future, neural prosthesesare rapidly becoming viable for patients withinjury or disease of the nervous system. Thisbook provides information on neural prosthetictechniques and applications. The first sectiondetails some of the most successful sensory andmotor prosthetic devices available, paying par-ticular attention to the usefulness and futurepromise of the devices. The second sectionexplores the growing field of brain-implantabledevices for the control of artificial prostheticdevices or neural prosthetics.


NeurosteroidEffects in theCentral NervousSystemThe Role of theGABAA ReceptorEdited by

Sheryl S. SmithSUNY Health Sciences Center,Brooklyn, New York, USA

“The overwhelming amount of information in thefield is well presented … superbly written … mag-nificent pictures … a good purchase for general neu-rological and neuroscience libraries.”

— Doody’s

Providing a complete overview of the effects ofsteroid hormones on the brain, this book dis-cusses theories on steroid action in the centralnervous system and the techniques for receptorlocalization and quantification and enzyme reg-ulation. It explores the use of transgenic/anti-sense strategies to determine sites and the cellu-lar effects of steroid action in the brain. The textcovers steroid action on mood, cognition, sen-sorimotor action, neuroprotection, and plastici-ty, and describes methods using molecular, elec-trophysical, and behavioral techniques.








New Conceptsin CerebralIschemiaEdited by

Rick C. S. LinUniversity of Mississippi MedicalCenter, Jackson, USA

Detailing the techniques and theories employed inboth basic and clinical research, New Concepts inCerebral Ischemia delineates the mechanismsunderlying neuronal damage induced byischemia. The book covers methods to elucidatethe pathogenesis of ischemia, technologies usedin the design of specific strategies to protect neu-rons from further injury, and approaches to treatpatients with acute ischemic episodes. It includesmethods and therapeutic approaches for neuronalprotection against acute and chronic ischemicepisodes and describes new animal models forischemia research including the application oftransgenic animals.


PrimateAuditionEthology andNeurobiologyEdited by

Asif A. GhazanfarPrinceton University, New Jersey, USA

Bringing together the knowledge of experts ondifferent aspects of primate auditory function,this book bridges the epistemological gapbetween primate ethologists and auditory neu-robiologists. Leading ethologists, comparativepsychologists, and neuroscientists who havedeveloped experimental approaches apply theirmethods to a variety of issues dealing with pri-mate vocal behavior and the neurobiology ofthe primate auditory system. The synthesis ofethological and neurobiological approaches toprimate vocal behavior presented in this bookwill yield a rich understanding of the acousticand neural bases of primate audition and shedlight on the evolutionary precursors to speech.


NicotinicReceptors inthe NervousSystemEdited by

Edward D. LevinDuke University Medical Center,Durham, North Carolina, USA

"Well known researchers from the Old and NewWorlds contributed to this book…presents an inte-grated approach to nicotine research that shouldhelp to identify critical neuropharmacologicalmechanisms for both adverse and potentially ther-apeutic effects of nicotine."

—Jacques le Houezec, SRNT Newsletter,October/November 2002

This volume provides integrated coverage of neu-ronal nicotinic systems relevant to smoking addic-tion and cognitive dysfunction. By bringingtogether molecular and neurochemical applica-tions, this book provides the key to understandingfunction and dysfunction of nicotinic systems andhow they are significant for disease, addiction, andthe development of drug treatments.


SerotoninReceptors inNeurobiologyEdited by

AmitabhaChattopadhyayCenter for Cellular & MolecularBiology, Hyderabad, India

This book explores serotonin receptors from abroad-based, multidisciplinary approach. Theapproaches described vary from molecular bio-logical techniques and fluorescence microscopyand imaging, to genetic manipulation in animalmodels. While each of these approaches has itsown advantages and limitations, the synthesis ofinformation and knowledge achieved from stud-ies using multiple approaches will result in a com-prehensive understanding of the underlying com-plex phenomena involved in serotonergic signal-ing and its implications in health and disease. Thetext describes specific experimental proceduresthat will be of use to researchers interested inaddressing similar problems involving other G-protein-coupled receptor signaling systems.






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SleepCircuits andFunctionsEdited by

Pierre-Hervé LuppiUniveristy of Lyon, France

This comprehensive resource discusses the majordiscoveries related to the circuits responsible forslow wave sleep (SWS), rapid eye movement(REM) sleep, narcolepsy, and the possible role ofsleep in memory and developmental processes.It also presents advances in sleep researchobtained by means of emerging technologies.Sleep: Circuits and Functions includes dataobtained by differential gene expression analy-sis, transgenic mice, and functional imaging aswell as theoretical concepts on the mechanismsregulating sleep.


TheNeurobiology of OlfactionEdited by

Anna MeniniS.I.S.S.A, Trieste, Italy

The Neurobiology of Olfaction provides a com-prehensive overview of the status of knowledgeand research in olfaction. Using an interdiscipli-nary approach, it includes content from geneticsto behavior and from nematodes to humans. Italso contains chapters about recent discoverieson odor coding from the olfactory epithelium tocortical centers and about neurogenesis in theolfactory epithelium and in the olfactory bulb.Each subject-specific chapter is written by a topresearcher in the area and provides an extensivelist of reviews and original articles for studentsand scientists interested in further readings.


The DynamicSynapseMolecular Methodsin IonotropicReceptor BiologyEdited by

Josef T. Kittler &Stephen J. MossUniversity College of London, UK

Exploring the diverse tools and technologiesused to study synaptic processes, this bookdelineates techniques, methods, and conceptualadvances for studying neurotransmitter recep-tors and other synaptic proteins. It describes arange of molecular, biochemical, imaging, andelectrophysiological approaches for studying thebiology of synapses. Specific topics include theuse of proteomics to study synaptic proteincomplexes, the development of phosphoryla-tion state specific antibodies, post-genomictools applied to the study of synapses and RNAinterference in neurons. Several chapters focuson methods for gene and protein delivery intoneuronal tissue.


The PrimateVisual SystemEdited by

Jon H. Kaas & Christine E. CollinsVanderbilt University, Nashville,Tennessee, USA

"Chapters are well written and offer clear examplesof complicated system interconnectivity. …detailed insight into a portion of the primate visual system… this book warrants its place as avalued reference book."

—Contemporary Topics in Laboratory Animal Science

Discussing the neural behavior of visuomotorprocessing in the primate brain, this book syn-thesizes knowledge on the anatomical and func-tional organization of the primate visual system.It describes methods for investigating the visualsystem and includes coverage of how the visualsystem is formed during development.








The Role of theNucleus of theSolitary Tract in GustatoryProcessingEdited by

Robert M. BradleyUniversity of Michigan, School of Dentistry, Ann Arbor, USA

"… an excellent compendium … useful to thoseinterested in this crucial first processing center forincoming gustatory information as well as forthose interested in comparing this part of thenucleus with its more caudal reaches dealing withgeneral visceral inputs."

— Thomas E. Finer, University of Colorado in Journal of Chemical Neuroanatomy, Volume 36

This volume documents the anatomy of theNST, explores the properties of synaptic trans-mitters and neurons in the NST, compares thegustatory NST with the caudal NST, and consid-ers the challenge involved with identifying NSTneural circuits.


The SuperiorColliculusNew Approaches forStudying SensorimotorIntegrationEdited by

William C. HallDuke University, Durham, North Carolina, USA

Adonis MoschovakisUniversity of Crete, Heraklion, Greece

Presenting information amassed from more than30 years of research, this book gathers togetherthe most important pieces of evidence regardingthe structure and function of the superior collicu-lus. It explores the involvement of the superior col-liculus in the control of gaze shift and rapid eyemovements and provides a detailed discussion ofstructural features as they relate to functionalproperties. Placing empirical data in the context oftheory, the editors use computational models ofthe superior colliculus as scaffolds around which toorganize psychophysical, neurological, anatomi-cal, and physiological findings concerning itsinvolvement in orienting movements.


TheSomatosensorySystemDeciphering the Brain's Own Body ImageEdited by

Randall J. NelsonUniversity of Tennessee,Memphis, USA

Exploring research in the understanding of howthe brain deals with its own body image, thisbook provides a review of pertinent literatureand offers comprehensive descriptions of techni-cal approaches. The material includes frame-works for the conceptualization of the system'srepresentations, scientific and clinical applica-tions that stem from these approaches based onthe concepts, and a discussion of tools used tostudy the interface of the brain and the body.The book provides computational strategies forsensorimotor integration of the mammalianbrain and includes algorithms for the design andimplementation of haptic interfaces and tactiledisplacement.

Catalog no. 2336, 2002, 424 pp.SBN: 978-0-8493-2336-2, $157.95 / £99.00

TRP Ion ChannelFunction inSensoryTransductionand CellularSignalingCascadesEdited by

Wolfgang B. Liedtke, MD, PH.D.Duke University Medical Center, Durham, North Carolina, USA

Stefan HellerOHNS, Stanford, California, USA

Written by those at the forefront of TRP ionchannel research, this volume explains the piv-otal function and behavior of these channels. Itsheds light on selected signal transduction inaxonal path-finding, and in vascular, renal, andauditory functions. While the book exploresfindings that will be of interest to those involvedwith advanced research, it also includes signifi-cant background material for those looking tofamiliarize themselves with this promising pathof inquiry.






13

Clinical Neuroscience


New!

EpilepsyMechanisms, Models, and TranslationalPerspectivesEdited by

Jong M. Rho and Raman SankarUniversity of California School of Medicine, Los Angeles, USA

Carl E. StafstromUniversity of Wisconsin, Madison, USA

Introduces Scientifically Promising Therapies

Pivotal advances in drug development andsurgical techniques, as well as the emergenceof innovative approaches such as electricalstimulation of the nervous system, have led toa substantial reduction in the morbidity andmortality of patients with epilepsy. At thesame time, remarkable developments in neu-roscience have enhanced our understandingof brain structure and function.

Epilepsy: Mechanisms, Models, andTranslational Perspectives incorporates newadvances that bring epilepsy therapies fromthe laboratory bench to the bedside and backagain. It brings together the work of morethan 70 of the field’s most respected and cut-ting-edge researchers and clinicians.

The idea for this book was inspired by theeditors’ collective desire to promote bridgingof the so-called translational divide—that is,covering innovative treatment strategiesbased on scientific principles that have yet tobe tested rigorously in the clinical setting, butyet may provide practitioners with new andpromising approaches toward epilepsy thera-peutics.

In 24 chapters, this comprehensive and up-to-date reference:

• Offers an overview of the basic anatomicand functional substrates of seizure genesis and considers novel pathogenicconcepts

• Examines antiepileptic drug therapy,including the latest on molecular targets

• Looks at the state of surgical treatmentsfor epilepsy and discusses advances in the fields of structural and functionalneuroimaging

• Reviews the variety of nontraditional therapeutic options, such as the ketogenic diet, the vagus nerve stimulator,immunomodulators, neurosteroids,herbs, and botanicals

• Investigates neuroendocrine, hormonal, and biobehavioral factors that influenceseizure susceptibility

• Provides a glimpse of what future epilepsy therapies might look like

Contents:

Scientific Foundations. Antiepileptic Drugs.Epilepsy Surgery. Alternative Therapies.Other Modulators of the Epileptic State.The Future of Epilepsy Therapy.

Catalog no. 8559X, June 2010, 684 pp., ISBN: 978-1-4200-8559-4 , $189.95 / £121.00


Bestseller!

Atlas ofFunctionalNeuroanatomySecond Edition

Walter J. Hendelman, M.D.University of Ottawa, Ontario, Canada

“… an excellent tool for introducing the basic con-cepts of neuroanatomy to medical students.Physicians in training could also use it as an easilymanageable method for refreshing basic concepts.The CD-ROM greatly enhances the utility andvalue of this book …”

—Estrada J. Bernard Jr., M.D.,Journal of Neurosurgery, Vol. 105

“A very useful Atlas for students in medicine andneuroscience as well as for trainees in neurology,anatomy, neurosurgery and allied neurosciences.”

—Pediatric Endocrinology Reviews (PER), Vol. 4, No. 3

Presenting a clear guide to understanding thehuman central nervous system, this second edi-tion includes numerous four-color illustrations,photographs, diagrams, radiographs, and histo-logical material throughout the text. The inter-active CD-ROM includes full text, color illustra-tions, 3-D visualization, roll-over labeling, andflash animations.

Features:

• Supplies a clear understanding the limbic system

• Presents an organized orientation of theCNS, sensory, and motor functional systems

• Provides a detailed histological study ofbrainstem and spinal cord neuroanatomy

Contents:

Orientation. Introduction. Overview. FunctionalSystems. Sensory Systems. Reticular Formation.Motor Systems. Neurological Neuroanatomy.Limbic System. Annotated Bibliography.Glossary

Catalog no. 3084, 2006, 296 pp., Soft CoverISBN: 978-0-8493-3084-1, $62.95 / £40.99

14

Clinical Neuroscience


The IntegratedNervous SystemA SystematicDiagnostic ApproachWalter J. Hendelman, M.D.University of Ottawa, Ontario, Canada

Peter HumphreysChildren's Hospital of Eastern Ontario, CanadaChristopher R. SkinnerOttawa Hospital, Ontario Canada

An Integrative Approach to NeurologicalDiagnosis

This introductory, full-color text teaches stu-dents and practitioners how to combine neuro-logical history and physical examination so theycan localize pathologies within the nervous sys-tem and determine appropriate treatment. Itprovides a wealth of illustrations that emphasizethe functioning nervous system, an invaluableDVD for further exploration and access to astate-of-the-art website updated periodically.

Removes the intimidation factor that makesneurology so challenging

• Includes neuroanatomical drawings related to case studies

• Provides informative tables with relevant clinical data

• Offers radiographic images, EEGS, microscopicimages, and other diagnostic tools

Includes A DVD for further exploration thatincludes:

• User-friendly worksheets to provide a provenmethodology for evaluation

• All color illustrations from the book• Flash animations of various pathways, reflexes, and circuits

• Neuroimaging primer to boost understandingof CT and MRI sequences

• Extensive case studies covering a completefamily with multiple diagnoses

Contents:

The Learning Contract. The Basics ofNeurological Problem Solving. TheNeurological Examination. Clinical ProblemSolving. Applying the Basics to Clinical Cases.Fifi. Cletus. Bernard. Bobo. Etienne. Armand.Didi. Chantal. Mickey. SupplementaryConsiderations: Rehabilitation and Ethics.Neurorehabilitation. Neuroethics.




15

Neuropsychology


AutismOxidative Stress,Inflammation, and ImmuneAbnormalitiesAbha Chauhan, Ved Chauhan, & Ted BrownNew York State Institute for Basic Research in DevelopmentalDisabilities, Staten Island, USA

Autism: Oxidative Stress, Inflammation, andImmune Abnormalities brings together a wealthof cutting-edge evidence that is already influ-encing how we treat this serious condition. Itlooks at the role of neuropathological abnormal-ities, genetics, and those factors common tooxidative stress such as inflammation, immunedysfunction, aberrant cellular signaling, andgene-environment interactions. Among dozensof research topics, this volume:

• Looks at interactions between genetic andenvironmental factors

• Summarizes evidence for oxidative damageand inflammation in autism

• Introduces a PDD behavior inventory as atool for assessing autism

• Considers autism as an aberrant adaptiveresponse to neuroinflammation and oxidativestress

• Examines the role of abnormal calcium signaling and the hypothesis that it may represent a target for novel therapeutics

• Presents a hypothesis that autism arises fromthe dysregulation of a unified gut/brain system rather than originating in the brain alone

• Proposes the utility of using a biopsychosocialmethod to treat autism

The findings in this book implicate oxidativestress as a common feature in autism, and sup-port the claim that oxidative stress and intracel-lular redox imbalance can be induced or trig-gered in autism by exposure to certain environ-mental agents.


Bestseller!

UnderstandingAutismFrom BasicNeuroscience toTreatmentEdited by

Steven O. MoldinUniversity of Southern California, Office of Research Advancement, Washington, DC, USA

John L.R. RubensteinUniversity of California, San Francisco, USA

"… an important book for anyone engaged in thecare of autistic individuals or in research in thearea…"

—Ronald J. Friedman, in PsycCRITIQUES, Vol. 52, No. 12, March 2007

" …a seminal work that makes a highly importantcontribution to the field of autism research."

—Pauline A. Filipek, M.D. in the New England Journal of Medicine, April 2007

"A 500-page guide for the march toward a cure forautism."

—Suzanne and Bob Wright, Founders, Autism Speaks, New York City

"This book, long overdue, is the essential surveyand summary of the tremendous advances the lastten years have brought in autism neuroscience.”

—Jonathan Shestack, Co-founder, Cure Autism Now, Los Angeles

With chapters authored by researchers at theforefront of molecular and systems neuro-science, clinical neuroscience, and health eco-nomics, this bestselling reference presents acomprehensive synthesis of research on autismand its underlying neural substrates. The book'seditors are considered pioneers in this area ofresearch. Dr. Rubenstein was elected to the pres-tigious Institute of the Medicine, an honorreserved for those most committed to profes-sional achievement and public service.





Neuropsychology

Coming Soon New Edition of a Bestseller!

Concussive Brain TraumaNeurobehavioral Impairment &Maladaption, Second EditionRolland S. ParkerNew York University School of Medicine, USA

Continuing in the tradition of the bestsellingfirst edition, this second edition provides com-prehensive coverage of neurobehavioral disor-ders in children and adults following impactand acceleration accidents. Completely revisedand updated with six new chapters, the bookincludes comprehensive coverage of conscious-ness including normal, acute, and persistentalterations. It also includes new material on dys-regulation of the internal environment. Drawing on his training, education, and experi-ence in human physiology, neuroanatomy, andendocrinology, the author not only gives read-ers a solid foundation for understanding, diag-nosing, and treating concussive brain trauma,but also gives them tools to increase standardsof care.

Contents:

Introduction to the PostconcussionSyndrome

Controversial Issues of Concussion

Consciousness

Brain Functioning

Trauma I

Trauma II

Trauma III

Trauma IV

Motor Disorders

Pain and Posttraumatic Headaches

Chronic Posttraumatic Disorders ofConsciousness

Information Processing, MentalEfficiency, and Executive Functioning

Cerebral Personality Disorders I

Cerebral Personality Disorders II

Cognitive Functioning

Personality Psychodynamics

Maladaptive Outcome

Multi-discipline ExaminationConsiderations

Features:

• Describes neurobehavioral disorders in children and adults following impact andacceleration accidents

• Covers consciousness including normal,acute, and persistent alterations

• Discusses personality and subjective complaints and symptoms

• Includes 6 new chapters and new materialon dysregulation of the internal environment

Catalog no. 8039, December 2010c. 976 pp., ISBN: 978-0-8493-8039-6

$159.95 / £99.00


17

Neuropsychology


New!

Traumatic Brain InjuryRehabilitation, Treatment, and Case Management, Third EditionEdited by

Mark J. AshleyCentre for Neuro Skills of California, Bakersfield, USA

Praise for the Previous Edition:

"An easy-to-follow account of the anatomy, phys-iology and pathophysiology of the vestibular sys-tem is followed by technical descriptions … avaluable resource to non-specialists."

—Journal of the Royal Society of Medicine, Vol. 97

"… an excellent resource and educational tool."—Diane V. Bistany, Vice President, General-Cologne

Reinsurance Corporation

Widening coverage from the previousedition, this book includes details on:

• Metabolic and bioenergetic factors in brain injury

• Neuroendocrine dysfunction following brain injury

• Blast injury

• Ethical issues in treatment of brain injury

• Neuropharmacological and neuropsychological interventions following brain injury

• Interventions for the minimally conscious patient

• Dietary and exercise considerationsafter brain injury

This new edition is a complete sourceof pharmacological, anatomical, andphysiological information for basictherapeutic rationales that are oftennot well understood in the field. It isan ideal reference for new and experi-enced clinicians.

Details Specific Approaches to Nearly All Aspects of Dysfunction

With updated and expanded clinical coverage,Traumatic Brain Injury: Rehabilitation,Treatment, and Case Management, ThirdEdition delineates a broad spectrum ofadvanced theoretical clinical constructs anddetailed diagnostic and treatment interventionsfor traumatic brain injury.

With contributions from more than 50 authori-ties in academia and industry, this highlyrespected text stands apart as a clinical guide torehabilitative treatment of persons with traumat-ic brain injury following the acute phase of treat-ment. It provides a concise source of informationabout the scientific and therapeutic realmsinvolved in the rehabilitation of a person withtraumatic brain injury, specifically as they relateto persistent deficits. The book also details long-term consequences of brain injury and effectiveapproaches to vocational rehabilitation and casemanagement.

Catalog no. 71947, May 2010, 1079 pp., ISBN: 978-1-4200-7194-8

$159.95 / £99.00



Neuroscience

This award winning series provides a com-plete record of the development of thehuman central nervous system from spinalcord gestation through the third trimester.The atlases are organized by coronal, sagit-tal, and horizontal planes of sectioning toensure that nearly every structure in thedeveloping brain is represented pictorially.

Each volume provides two-page spreads con-taining high resolution black and whiteimages on one side and ghost images on theother with unabbreviated labels to apprisereaders of the exact structures identified. Thefinal volume provides a concluding essay thatsummarizes major events of CNS develop-ment, while offering a theoretical account ofthe morphogenetic processes involved.

From the 1960s through the 1980s, the workof legendary pioneers Shirley Bayer andJoseph Altman chronicled the developmentof the rat nervous system. In the 1990s, theyshifted their attention to humans when theyrealized how little was known about thedevelopment of the human central nervoussystem. Bayer and Altman decided to applytheir knowledge of rat nervous system devel-opment to humans by directly examininghistological sections of normal human speci-mens. They took over 10,000 photographsof the best preserved specimens available.Each photo was scanned to create digitalizedfiles that could be further examined withsophisticated equipment, including 3-dimensional reconstruction software.

This set of atlases is the result of this effort.This information is included in an extendedmonograph in Volume 5 that will no doubtserve as a launching pad for future research.

The Spinal Cord from GestationalWeek 4 to the 4th Postnatal MonthFirst Prize Winner in the Medicine Category,2003 British Medical Association Library BookCompetitionCatalog no. 1420, 2002, 256 pp.ISBN: 978-0-8493-1420-9, $229.95 / £147.00

The Human Brain During theSecond Trimester" … an excellent exposition of the fetal humanbrain development … contains valuable informa-tion not readily accessible elsewhere…”

- Hajnalka Abraham, Journal of Chemical Neuroanatomy, Vol. 36


The Human Brain During the Third TrimesterHighly Commended in the OB/GYN Categoryat the 2004 British Medical Association LibraryBook Competitio


The Human Brain During the Late First TrimesterCatalog no. 1423, 2006, 592 pp.ISBN: 978-0-8493-1423-0, $199.95 / £127.00

The Human Brain During the Early First Trimester"… the definitive histological resource for thestudy of human brain development. … I highlyrecommend this atlas . . ."

– Jennifer Brueckner, Ph.D, in Doody’s Core Titles, 2009


Catalog no. 68008, 2008ISBN: 978-1-4200-6800-9$786.00 / £501.00

Atlas of Human Central Nervous System DevelopmentFive-Volume SetShirley A. Bayer & Joseph AltmanIndianapolis, Indiana, USA

Buy the Set & Save!














19

Neuroscience


Coming Soon!

MaldyniaMultidisciplinary Perspectives on theIllness of Chronic PainEdited byJames GiordanoGeorgetown University, Washington, DC, USA

An in depth examination of maldynia, alsoknown as chronic pain, this book explores painas a bio-cultural phenomenon that necessitatesreexamination of medical philosophy, ethics,education, and practice. It provides a historicalaccount of pain and then frames it with con-temporary neurobiological perspectives. Thisbook supplies a foundation upon which to illus-trate (1) how what we know about pain couldand should influence medical education, andthe scope, and value (s) of medical practice, and(2) how a knowledge of the history and presentconsiderations of pain might help to constructmeaningful, patient-centered medicine.

Contents:

The Illness of Chronic Pain. A ShortHistory. Pain Does Not SufferMisprision. The Phenomenologyand Neurobiology of the Experienceof Illness and of Pain. The Problemof Empathy and Hermeneutics inPain Care. Spirituality, Suffering andthe Self. History of the Expression ofPain in Art. A Recent Experiment inthe Visual Arts and MedicalHumanities. Maldynic Pain in Imageand Experience. MusicalRepresentations of Physical Pain.Narrative in Pain Medicine.Psychological Assessment ofMaldynic Pain. Painism- A NewEthics: Richard Ryder’s Moral Theoryand Its Limitations. Maldynia:Chronic Pain, Complexity andComplementarity. A Clinical Ethicsof Chronic Pain Management: Basis,Reason and Responsibilities.Children, Pain, and the Creation ofSuffering. Goal-Directed Health Careand the Chronic Pain Patient. TheProblem of Pain and the MoralFormation of Physicians.

Features:

• Represents an integrative perspective thatexamines the phenomena of pain from a biologic, medical, philosophical, and socio-cultural aspect

• Brings together noted scholars from diversedisciplines convergent upon the core themeof causes, manifestations, historical relevanceand implications of a major public healthissue

• Presents pain as a bio-cultural phenomenonthat necessitates re-examination of medicalphilosophy, ethics, education, and practice

• Provides a historical account of pain, andthen frames this in the most contemporaryneurobiological perspectives

• Discusses how a knowledge of the historyand present considerations of pain mighthelp to construct more meaningful, patient-centered medicine in the future

Catalog no. K11642, December 2010c. 280 pp., ISBN: 978-1-4398-3630-9

$149.95 / £95.00



Lab Animal Science

Laboratory Animal Pocket Reference SeriesTwelve-Volume Set

Edited by

Mark A. Suckow“The handbooks provide quick reference to the most commonly utilizedspecies in animal research in a compact, easy-to-read format. Each volumein the series can serve as a standalone reference … conveniently sized andare well written in an organized, easy to read manner … "

—Animal Laboratory News, Sept/Oct 2003

Buy the Set & Save!

Catalog no. 2560, 2000ISBN: 978-0-8493-2560-1$570.00 / £363.00

Also available as stand-alone references

New! The Laboratory Rabbit,Second EditionCatalog no. 91050, April 2010, 148 pp.,Soft CoverISBN: 978-1-4200-9105-2, $59.95 / £38.99

The Laboratory Xenopus spCatalog no. 91093, January 2010, 180 pp., Soft CoverISBN: 978-1-4200-9109-0, $59.95 / £38.99

The Laboratory Swine,Second EditionCatalog no. K10783, February 2010, 138 pp., SoftCover, ISBN: 978-1-4398-1528-1, $59.95 / £38.99

The Laboratory MouseCatalog no. 0322, 2001, 184 pp., Soft CoverISBN: 978-0-8493-0322-7, $55.95 / £35.99

The Laboratory Nonhuman PrimateCatalog no. 2562, 2002, 288 pp., Soft CoverISBN: 978-0-8493-2562-5, $57.95 / £36.99

The Laboratory Guinea PigCatalog no. 2564, 1998, 192 pp., Soft CoverISBN: 978-0-8493-2564-9, $55.95 / £35.99

The Laboratory RatCatalog no. 2565, 1998, 240 pp., Soft CoverISBN: 978-0-8493-2565-6, $55.95 / £35.99

The Laboratory Hamster and GerbilCatalog no. 2566, 1999, 168 pp., Soft CoverISBN: 978-0-8493-2566-3, $55.95 / £35.99

The Laboratory CatCatalog no. 2567, 1998, 160 pp., Soft CoverISBN: 978-0-8493-2567-0, $55.95 / £35.99

The Laboratory SmallRuminantCatalog no. 2568, 1999, 176 pp., Soft CoverISBN: 978-0-8493-2568-7, $55.95 / £35.99

The Laboratory CanineCatalog no. 2893, 2007, 184 pp., Soft CoverISBN: 978-0-8493-2893-0, $55.95 / £35.99

The Laboratory ZebrafishClaudia HarperAmgen Inc., Cambridge, Massachusetts, USA

Christian LawrenceChildren's Hospital Boston, Massachusetts, USA

Catalog no. K10378, December 2010, c. 256 pp., Soft CoverISBN: 978-1-4398-0743-9, $59.95 / £38.99

Coming Soon!


































21

Lab Animal Science


New!

Laboratory Mouse andLaboratory Rat ProceduralTechniquesManuals and DVDsJohn J. Bogdanske, Scott Hubbard Van Stelle,Margaret Rankin Riley, & Beth M. SchiffmanUniversity of Wisconsin, Madison, USA

Illustrated Techniques of the Proper Handlingof Research Mice and Rats

Currently, there is a paucity of training material forexperimental techniques in laboratory rodents, par-ticularly audiovisual material. The manuals andaccompanying DVDs will be of great interest to stu-dents, technicians, veterinarians, and investigators.Importantly, the straightforward approach taken inboth the printed manual and DVD will be seen as anexcellent tool for non-English speaking personnel.

—Mark A. Suckow, DVM, Dipl. ACLAM, Director, Freimann Life Science Center, University of

Notre Dame, & Past President of AALAS

Persons (students of animal technology) can watchthese videos to 'get the picture' and then practice withan experienced individual. It is a good refinement stepof the 3Rs….I will be very excited to have these man-uals to use as training items with my students and asreference resources in our animal facility.

—Bruce W. Kennedy, MS, RLATG, CMAR, Compliance Associate, Research & Graduate Studies,

California State Polytechnic University, Pomona, & Past President of AALAS

Laboratory Mouse Procedural TechniquesManual and DVDCatalog no. K12294, November 2010, 98 pp., Soft CoverISBN: 978-1-4398-5042-8, $59.95 / £38.99

Laboratory Rat ProceduralTechniquesManual and DVDCatalog no. K12295, November 2010, 82 pp., Soft CoverISBN: 978-1-4398-5044-2, $59.95 / £38.99

On DVD with Full-ColorCompanionManuals

This combination of manuals and DVDs providesmuch-needed training on the proper handling ofmice and rats used in biomedical research. TheDVDs include narrated video clips that demonstrateand describe each procedural technique. The man-uals contain handouts with color illustrations anddescriptive text for each technique, including thepurpose and application of the procedure, recom-mended skills, and necessary supplies. The pair canbe used as a training resource and refresher for labanimal veterinarians, veterinary technicians, animalcare staff, trainers, and research investigators andstaff who work with mice and rats.

Each DVD provides:

• Narrated video clips that demonstrate anddescribe each procedural technique

• Easy navigation to desired techniques

Each Manual includes:

• Full text narratives and procedural handoutswith full-color illustrations of each techniqueincluded on the DVD —including purpose andapplication of the procedure, recommendedskills, and necessary supplies

• Supplementary chapters that provide normativedata for the laboratory rat and mouse

Buy the set and save!Two Manuals and Two DVDs

Catalog no. K12298, November 2010192 pp., Soft Cover, ISBN: 978-1-4398-5050-3

$108.00 / £68.99

Also available as individual volumes





New!

The COSTManual ofLaboratoryAnimal Care and UseRefinement,Reduction, and ResearchEdited byBryan Howard(retired) Director of Animal Welfare, University of Sheffield, UKTimo NevalainenUniversity of Kuopio, FinlandGemma PerrettaItalian National Research Council, Santa Maria di Galeria, Italy

COST (European Cooperation in the field ofScientific and Technical Research) is an intergov-ernmental initiative in science and researchintended to promote the coordination of nation-ally funded research at a European level. In labo-ratory animal science, four working groups wereestablished to discuss the housing of animals,environmental needs, refinement of procedures,genetically modified animals, and cost-benefitanalysis. Based on the activities of these workinggroups, this book provides the European bestpractices for individuals and institutions workingwith laboratory animals. The text also provides aguide for the ethical evaluation of experimentsand procedures involving animals.Catalog no. K11184, October 2010, 439 pp.ISBN: 978-1-4398-2492-4, $89.95 / £57.99

Coming SoonThird Edition of a Bestseller!

Handbook ofLaboratoryAnimal ScienceVolume I, Third EditionEssential Principles and PracticesEdited by

Jann HauUniversity of Copenhagen & Rigshhospitalet, Denmark

Steven SchapiroThe University of Texas, Bastrop, Texas, USA

This comprehensive handbook explores themyriad issues surrounding the use of animals inscientific laboratories. Topics in this volumeinclude the history of animal research, ethicalconcerns, regulation and legislation, facilitiesand equipment, genetics, health monitoring,nutrient requirements and feeding schedules,statistical analysis, surgical and non-surgicaltechniques, and anesthesia. The book alsoexplores alternatives to lab animal use with a dis-cussion of the refinement, reduction, andreplacement of animal uses in the life sciences.Catalog no. 84550, December 2010, c. 624 pp.ISBN: 978-1-4200-8455-9, $149.95 / £95.00

TranslationalPain ResearchFrom Mouse to ManEdited by

Lawrence KrugerUniversity of California, Los Angeles, USA

Alan R. LightUniversity of Utah, Salt Lake City, USA

Bringing together recent advances in modernneuroscience regarding genetic studies in miceand humans and the practicality of clinical trials,this book examines rodent models for pain asso-ciated with bone cancer, osteoarthritis, and car-diac episodes. It covers the cloning of highlyspecific receptors and the analysis of modularmolecular mechanisms relevant to painful neu-ropathies, while also considering the bearing ofthis trend toward translational research on thecommercial pharmaceutical establishment.

Catalog no. K10609, January 2010, 432 pp.ISBN: 978-1-4398-1209-9, $159.95 / £99.00

Lab Animal Science

Coming Soon!

Atlas of the Neonatal Rat BrainRenuka Ramachandra & Thyagarajan SubramanianPenn State Hershey Medical Center, Pennsylvania, USA

This histological atlas of the rat neonatal brainprovides detailed color images of the normaldeveloping rat brain. Each plate is a photomi-crograph composite that shows the entire brainin sagittal and coronal sections at each stagestained with cresyl violet. Various brain nucleiand their connections are specifically labeled.Since changes in the rat brain post-birth are sorapid, images are provided for postnatal daysone, five, and fifteen.

Catalog no. K11857, February 2011, c. 224 pp.ISBN: 978-1-4398-4012-2, $159.95 / £57.99





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