Nedley Depression and Nedley Depression and Anxiety Recovery ProgramAnxiety Recovery Program

THE POWER OF THE BRAINTHE POWER OF THE BRAIN

DETAILS OF THE HUMAN DETAILS OF THE HUMAN BRAINBRAIN

The most complicated The most complicated structure ever investigated by structure ever investigated by

sciencescience• 100 billion nerve cells100 billion nerve cells• Even more supporting cells known as Even more supporting cells known as GliaGlia• Thousands of different types of neuronsThousands of different types of neurons

Regular neurons make 1,000 connections with other neurons The Purkinje Cell can make 200,000 connections There are an estimated 100 trillion synapses in the brain, but it is conjectured there could be 10 times more

Mind Character Personality Vol Mind Character Personality Vol 1 Page 41 Page 4

• ““To deal with minds is the greatest To deal with minds is the greatest work ever committed to men.” work ever committed to men.”

Depression is IncreasingDepression is Increasing• The number of people The number of people

developing developing depression worldwide depression worldwide has steadily has steadily increased since 1915.increased since 1915.

• Major episodes of Major episodes of depression now occur depression now occur frequently by age 25.frequently by age 25.

• Overall risk of Overall risk of depression has depression has increased over time.increased over time.

How Can I Know if it’s Major How Can I Know if it’s Major Depression?Depression?

• Deep sadnessDeep sadness

• ApathyApathy

• AgitationAgitation

• Sleep disturbancesSleep disturbances

• Weight or appetite Weight or appetite changeschanges

• Lack of concentrationLack of concentration

• Feelings of Feelings of worthlessnessworthlessness

• Morbid thoughtsMorbid thoughts

• FatigueFatigue

Cannot have recently faced obvious emotional trauma but still Cannot have recently faced obvious emotional trauma but still experiences at least 5 of the 9 symptoms for at least 2 weeks.experiences at least 5 of the 9 symptoms for at least 2 weeks.

Subsyndromal Depression = 2 to 4 symptoms for 2 weeks.Subsyndromal Depression = 2 to 4 symptoms for 2 weeks.

Depression Increases Risk of Depression Increases Risk of DeathDeath

• Increases risk of stroke by Increases risk of stroke by 50%50%

• Increases risk of sudden Increases risk of sudden cardiac death in post-MI cardiac death in post-MI survivors by 2½ timessurvivors by 2½ times

• Increases risk of heart disease Increases risk of heart disease in menin men

• Increases risk of death from Increases risk of death from cancercancer

• Increases risk of death from Increases risk of death from pneumoniapneumonia

• Increases risk of suicideIncreases risk of suicideJournal of Epidemiology. 1997;7:210-213. Journal of Epidemiology. 1997;7:210-213. British Medical Journal. 1998;316:1714-1719.British Medical Journal. 1998;316:1714-1719.

What About Suicide?What About Suicide?• Over 1 million people commit suicide Over 1 million people commit suicide

every year in this world, and number is every year in this world, and number is going up, one death every 40 secondsgoing up, one death every 40 seconds

• Rates in South Africa 14Rates in South Africa 14thth in world in world• Two per hour, 20 or more attempts per Two per hour, 20 or more attempts per

hourhour• Feelings of hopelessness is the best Feelings of hopelessness is the best

correlate of imminent suicidal actioncorrelate of imminent suicidal action• Other factors are impaired judgment or Other factors are impaired judgment or

coping skills, impulsivity, isolation, coping skills, impulsivity, isolation, history of mental illnesshistory of mental illness

Effects of DepressionEffects of Depression• May cause a chronic May cause a chronic

headacheheadache• May cause osteoporosisMay cause osteoporosis• When combined with When combined with

stress, increases risk of stress, increases risk of HIV progressing to AIDSHIV progressing to AIDS

• Increases risk of return Increases risk of return to addictive behavior to addictive behavior such as drinkingsuch as drinking

Archives of General Psychiatry. 1998;55:259-265.Archives of General Psychiatry. 1998;55:259-265.American Journal of Psychiatry. 1997; 154(5):630-634.American Journal of Psychiatry. 1997; 154(5):630-634.The Journal of the American Medical Association. 1998; 279:1720-1726.The Journal of the American Medical Association. 1998; 279:1720-1726.

• May increase May increase problems with anger problems with anger or hostilityor hostility

Effects of DepressionEffects of Depression• Increases risk of developing asthmaIncreases risk of developing asthma• Increases chance that offspring will suffer Increases chance that offspring will suffer

depression and physical medical problemsdepression and physical medical problems• Increases rate of decline in physical abilities Increases rate of decline in physical abilities

with agewith age• Increases stress hormonesIncreases stress hormones• Decreases sex hormonesDecreases sex hormones• Decreases CD8, Increases IgA, Decreases Decreases CD8, Increases IgA, Decreases

IgM, impairing immune systemIgM, impairing immune system• Decreases memoryDecreases memory

Archives of General Psychiatry. 1998;55:259-265.Archives of General Psychiatry. 1998;55:259-265.American Journal of Psychiatry. 1997; 154(5):630-634.American Journal of Psychiatry. 1997; 154(5):630-634.The Journal of the American Medical Association. 1998; 279:1720-1726.The Journal of the American Medical Association. 1998; 279:1720-1726.

The Cost of DepressionThe Cost of Depression• Lose 5.6 hours on average of productive Lose 5.6 hours on average of productive

work per week.work per week.• 80 percent are impaired in daily 80 percent are impaired in daily

functioningfunctioning– less ability to concentrate, lower efficiency, less ability to concentrate, lower efficiency,

and less ability to organize workand less ability to organize work

• Over twice as likely to take sick daysOver twice as likely to take sick days• In one study, the costs of absenteeism In one study, the costs of absenteeism

were directly related to taking were directly related to taking antidepressant medicationantidepressant medication

• Depressed people are seven times more Depressed people are seven times more likely to become unemployedlikely to become unemployed

Stewart, 2003; Pratt & Brody, 2008 Adler, et al., 2006; Greener & Guest, Stewart, 2003; Pratt & Brody, 2008 Adler, et al., 2006; Greener & Guest, 2007; 2007; Birnbaum, et al., 2010; Dewa, Hoch, Lin, Paterson, & Goering, 2003; Birnbaum, et al., 2010; Dewa, Hoch, Lin, Paterson, & Goering, 2003; Lerner, et al., 2004Lerner, et al., 2004

The long-term effects of The long-term effects of psychological problems during psychological problems during childhoodchildhood• Children were followed for 40 years to Children were followed for 40 years to

determine the effects of illness and determine the effects of illness and psychological problems on their life chancespsychological problems on their life chances

• Seven fewer weeks of work per year, a loss Seven fewer weeks of work per year, a loss of 35 percent in lifetime income, and a of 35 percent in lifetime income, and a lifetime loss for each family who has a lifetime loss for each family who has a depressed family member of $300,000depressed family member of $300,000

• Personal loss (on average) of $10,400 per Personal loss (on average) of $10,400 per year in income by age 50year in income by age 50

• The cost for the total group--over one's The cost for the total group--over one's lifetime-2.1 trillion dollars which does not lifetime-2.1 trillion dollars which does not include the increased cost of medical care include the increased cost of medical care that all of us must assume. that all of us must assume.

Smith, J. P., & Smith, G. C. (2010). Long-term economic costs of psychological Smith, J. P., & Smith, G. C. (2010). Long-term economic costs of psychological problems during childhood. Social Science & Medicine, 71, 110-115.problems during childhood. Social Science & Medicine, 71, 110-115.

Number One Cause of Number One Cause of Disability WorldwideDisability Worldwide

• 76.4 million years lost to productivity76.4 million years lost to productivity

• 10.4 percent of total burden of 10.4 percent of total burden of diseasedisease

• Far more than any other conditionFar more than any other condition

Ministry of Healing 241Ministry of Healing 241

““The condition of the mind affects the The condition of the mind affects the health to a far greater degree than health to a far greater degree than many realize. many realize.

Many of the diseases from which men Many of the diseases from which men suffer are the result of mental suffer are the result of mental depression. depression.

Grief, anxiety, discontent, remorse, guilt, Grief, anxiety, discontent, remorse, guilt, distrust, all tend to break down the life distrust, all tend to break down the life forces and to invite decay and death.” forces and to invite decay and death.”

The Journal Nature The Journal Nature November 12 issue of 2014November 12 issue of 2014• Entire issue dedicated to DepressionEntire issue dedicated to Depression

• ““We are doing better with the treatment of We are doing better with the treatment of cancer than we are with the treatment of cancer than we are with the treatment of depression”depression”

• Current medications have severe limitations and Current medications have severe limitations and are clearly not the answerare clearly not the answer

• Best medicines only improve functionality in 13 Best medicines only improve functionality in 13 percent of patientspercent of patients

• Editors make a plea for real research that Editors make a plea for real research that makes a real difference in treating this diseasemakes a real difference in treating this disease

Causes of Major DepressionCauses of Major Depression

• Myriads of CausesMyriads of Causes– Well over one hundredWell over one hundred

• Most fall into one of ten categoriesMost fall into one of ten categories

• Depression is most often a Depression is most often a multifactorial diseasemultifactorial disease– Usually four categories of causes or Usually four categories of causes or

more combinedmore combined

The Ten “Hit” CategoriesThe Ten “Hit” Categories

1.1. GeneticGenetic

2.2. DevelopmentalDevelopmental

3.3. LifestyleLifestyle

4.4. Circadian Circadian RhythmRhythm

5.5. AddictionAddiction

6.6. NutritionNutrition

7.7. ToxicToxic

8.8. Social/Social/Complicated Complicated Stress or GriefStress or Grief

9.9. Medical ConditionMedical Condition

10.10. Frontal LobeFrontal Lobe

Winter DepressionWinter Depression• 96 patients were randomized to 96 patients were randomized to

receive light therapy plus a placebo receive light therapy plus a placebo capsule or placebo light therapy plus capsule or placebo light therapy plus Prozac (20 mg/day) for 8 weeks. Prozac (20 mg/day) for 8 weeks.

• The clinical response rate in each The clinical response rate in each group was 67 percent.group was 67 percent.

• Further analysis indicated that light Further analysis indicated that light therapy provided a quicker initial therapy provided a quicker initial improvement. improvement.

RW Lam American Journal of Psychiatry, May 2006

Omega 3 Supplements Help Manic Depression Patients receiving omega 3 supplements “had a Patients receiving omega 3 supplements “had a

significantly longer period of remission (from significantly longer period of remission (from illness) than the placebo group.” Patients receiving illness) than the placebo group.” Patients receiving omega 3 supplements also displayed considerable omega 3 supplements also displayed considerable improvement on tests assessing levels of improvement on tests assessing levels of depression and other bipolar symptoms. depression and other bipolar symptoms.

In an editorial, Dr. Joseph Calabrese and colleagues In an editorial, Dr. Joseph Calabrese and colleagues at Case Western Reserve University in Cleveland, at Case Western Reserve University in Cleveland, Ohio, call the trial a “landmark attempt in drug Ohio, call the trial a “landmark attempt in drug development for bipolar disorder.” development for bipolar disorder.”

Archives of General Psychiatry 1999;56:407-412, Archives of General Psychiatry 1999;56:407-412, 413-414, 415-416413-414, 415-416

Fish High in Omega 3Fish High in Omega 3FishFish AmountAmount Omega-3 (mg)Omega-3 (mg)

Drum fishDrum fish 1 ea.1 ea. 810810

Tuna (in water)Tuna (in water) 1 serv.1 serv. 930930

Rainbow troutRainbow trout 1 ea.1 ea. 11801180

Freshwater bassFreshwater bass 3.5 oz3.5 oz 11901190

Pink SalmonPink Salmon 3.5 oz3.5 oz 17101710

HerringHerring 3.5 oz3.5 oz 30003000

HalibutHalibut 3.5 oz3.5 oz 31603160

Shad filletShad fillet 1 cup1 cup 36803680

Atlantic mackerelAtlantic mackerel 3.5 oz3.5 oz 39303930

Biomagnification of DDD Biomagnification of DDD InsecticideInsecticide

Lake waterLake water 0.020.02

Phytoplankton (living in DDD-contaminated water)Phytoplankton (living in DDD-contaminated water) 55

Herbivorous fish (they eat the phytoplankton)Herbivorous fish (they eat the phytoplankton) 40-30040-300

Carnivorous fish (they eat the herbivorous fish)Carnivorous fish (they eat the herbivorous fish) up to 2500up to 2500

In parts per million (ppm) in Clear Lake, CAIn parts per million (ppm) in Clear Lake, CA

Sample SiteSample Site DDD, ppmDDD, ppm

Mercury and FishMercury and FishThe connection between eating fish The connection between eating fish and body mercury levels is so strong and body mercury levels is so strong

that researchers seeking to determine that researchers seeking to determine mercury exposures among groups of mercury exposures among groups of people often look at only one dietary people often look at only one dietary

factor: fish consumption.factor: fish consumption.

(1) Levy M, et al. Childhood urine mercury excretion: dental (1) Levy M, et al. Childhood urine mercury excretion: dental amalgam and fish consumption as exposure factors. Environ amalgam and fish consumption as exposure factors. Environ

Res. 2004 Mar;94(3):283-90.Res. 2004 Mar;94(3):283-90.(2) Bjornberg KA, et al. Methyl mercury and inorganic mercury (2) Bjornberg KA, et al. Methyl mercury and inorganic mercury in Swedish pregnant women and in cord blood: influence of fish in Swedish pregnant women and in cord blood: influence of fish consumption. Environ Health Perspect. 2003 Apr;111(4):637-41.consumption. Environ Health Perspect. 2003 Apr;111(4):637-41.

Plant Foods Containing Plant Foods Containing Omega-3 (Linolenic Acid)Omega-3 (Linolenic Acid)

Flaxseed/Linseed oilFlaxseed/Linseed oil 1 Tbs.1 Tbs. 75267526

Walnuts, EnglishWalnuts, English ¼ cup¼ cup 17031703Walnuts, blackWalnuts, black ¼ cup¼ cup 10341034

Wheat germ oilWheat germ oil 1 Tbs.1 Tbs. 938938Soybean oil (Crisco/Wesson)Soybean oil (Crisco/Wesson) 1 Tbs.1 Tbs. 927927Green soybeansGreen soybeans 1 cup1 cup 637637Spinach cannedSpinach canned 1 cup1 cup 353353AlmondsAlmonds ¼ cup¼ cup 136136

Food ItemFood Item AmountAmount Omega-3 (mg)Omega-3 (mg)

Chia SeedsChia Seeds 1 Tbs.1 Tbs. 72897289

ESHA Research 3nd Edition 2000

Hypercholesterolemia and Hypercholesterolemia and DepressionDepression

• Patients with major depressive Patients with major depressive disorder (MDD) tend to have disorder (MDD) tend to have significantly higher cholesterol levels significantly higher cholesterol levels than healthy adults, than healthy adults,

• MDD patients with elevated MDD patients with elevated cholesterol have a poorer prognosis cholesterol have a poorer prognosis for treatment response. for treatment response.

Papakostas GI, Petersen T, Mischoulon D, Hughes ME, Alpert JE, Nierenberg AA, Rosenbaum JF, Fava M. Serum cholesterol and serotonergic function in major depressive disorder. Psychiatry Res. 2003 May 30;118(2):137-45.

Cholesterol in FoodsCholesterol in Foods

FruitsFruits 00GrainsGrains 00NutsNuts 00VegetablesVegetables 00

Milk, non-fat, 1cMilk, non-fat, 1c 44Milk, 2%, 1cMilk, 2%, 1c 1818Milk, whole, 1cMilk, whole, 1c 3333

Egg WhiteEgg White 00MayonaiseMayonaise 88Ice Cream, 1/2cIce Cream, 1/2c 2929Butter, 1 TbsButter, 1 Tbs 3131Egg, 1 largeEgg, 1 large

213213TunaTuna 2626ClamsClams 5757CrabCrab 6464

Items (3 oz.)Items (3 oz.) Chol. Chol. (mg)(mg)

Items (3 oz.)Items (3 oz.) Chol. Chol. (mg)(mg)

Cholesterol in FoodsCholesterol in Foods

Beef, sirloinBeef, sirloin 8080Chicken breast &Chicken breast & 8282

skinskinOysterOyster 8484SardinesSardines

120120

ShrimpShrimp 165165Beef kidneyBeef kidney

329329Beef liverBeef liver410410CaviarCaviar500500Beef brainsBeef brains16971697

Items (3 oz.)Items (3 oz.) Chol. Chol. (mg)(mg)

Items (3 oz.)Items (3 oz.) Chol. Chol. (mg)(mg)Chicken breast,Chicken breast, 7373

no skinno skinPorkPork 7676

Vascular Damage from Vascular Damage from Oxidized CholesterolOxidized Cholesterol

Oxidized cholesterol fed to rabbits and Oxidized cholesterol fed to rabbits and monkeys produced dramatic vascular monkeys produced dramatic vascular damage within 24 hours.damage within 24 hours.

Pure, non-oxidized cholesterol producedPure, non-oxidized cholesterol produced

no vascular damage.no vascular damage.

Foods Containing Harmful Foods Containing Harmful Cholesterol By-ProductsCholesterol By-Products

1. Custard mixes1. Custard mixes

2. Pancake mixes2. Pancake mixes

3. Parmesan Cheese3. Parmesan Cheese

3. Lard3. Lard

Sources of the most harmful cholesterol to monkey aortas are:Sources of the most harmful cholesterol to monkey aortas are:

““Especially Harmful”Especially Harmful”

““Especially harmful are the Especially harmful are the custards and puddings in which custards and puddings in which milk, eggs, and sugar are the milk, eggs, and sugar are the chief ingredients. The free use of chief ingredients. The free use of milk and sugar together should milk and sugar together should be avoided.”be avoided.”

Ellen G White. The Ministry of Healing. Pg. 301.Ellen G White. The Ministry of Healing. Pg. 301.

Research in the 1990s and Research in the 1990s and 2000s2000sIt is now well established that one of It is now well established that one of

the main characteristics of virtually the main characteristics of virtually all depressed individuals—no all depressed individuals—no matter what the underlying causematter what the underlying cause—is a significant decrease in the —is a significant decrease in the frontal lobe’s blood flow and frontal lobe’s blood flow and activity.activity.

Spect Scan

What Really What Really Comes First?Comes First?

Drevets presents Drevets presents compelling compelling evidence that evidence that frontal lobe frontal lobe problems are the problems are the cause, cause,

and the effects are and the effects are depressive depressive symptoms.symptoms.

General Treatment General Treatment MeasuresMeasures

• Just as many beneficial treatments as Just as many beneficial treatments as causescauses

• Although many of these modalities Although many of these modalities rigorously tested and proven, most rigorously tested and proven, most not utilized in standard practicesnot utilized in standard practices

• Began utilizing these measures with Began utilizing these measures with wonderful resultswonderful results

What What we think affects we think affects who who we arewe are..

Patients ImprovePatients Improve

• Once the program utilized began Once the program utilized began seeing unprecedented improvement seeing unprecedented improvement in many patients, some who had in many patients, some who had been chronically depressed for yearsbeen chronically depressed for years

• ““You’ve given me my life back.”You’ve given me my life back.”

• ““You’ve given me my wife back.”You’ve given me my wife back.”

• ““Doctor, I hope you don’t mind, but Doctor, I hope you don’t mind, but I’m going to hug your neck!”I’m going to hug your neck!”

Medication WithdrawalMedication Withdrawal

• 90 percent success rate in those who 90 percent success rate in those who adhere to the programadhere to the program

• Such patients often feel better than Such patients often feel better than they have felt their entire livesthey have felt their entire lives– Getting more doneGetting more done– More efficientMore efficient– Social problems vanishSocial problems vanish– Able to concentrate and accomplish Able to concentrate and accomplish

advanced planning and thinkingadvanced planning and thinking

Depression Recovery Depression Recovery SeminarSeminar• An eight week seminarAn eight week seminar

– One night each weekOne night each week

• Depression—the Way Out (Nedley) textbookDepression—the Way Out (Nedley) textbook

• Accompanying Work BookAccompanying Work Book

• Telling Yourself the Truth—William BackusTelling Yourself the Truth—William Backus

• SOS for Emotions—Lyn ClarkSOS for Emotions—Lyn Clark

• The Lost Art of Thinking—Neil NedleyThe Lost Art of Thinking—Neil Nedley

• Brighten Up Breakfast Cookbook—Erica Brighten Up Breakfast Cookbook—Erica NedleyNedley

• Get trained at drnedley.comGet trained at drnedley.com

Don’t Wait for Depression’s Don’t Wait for Depression’s ComplicationsComplications• Learn the principles of optimal brain Learn the principles of optimal brain

performanceperformance

• Learn how you can change your brainLearn how you can change your brain

• Learn to recognize distortions in Learn to recognize distortions in thought, and how to change those thought, and how to change those thoughts to non distorted truthful thoughts to non distorted truthful thoughts thoughts

• Make the choices that will positively Make the choices that will positively impact your emotions, and behavior, impact your emotions, and behavior, and your life longterm.and your life longterm.

For Seminar or Material For Seminar or Material InformationInformation• When and where a seminar will be held in When and where a seminar will be held in

your areayour area

• How to purchase the book, “Depression—How to purchase the book, “Depression—The Way Out.”The Way Out.”

• How to get the 8 part video series How to get the 8 part video series “Depression Recovery with Dr. Neil “Depression Recovery with Dr. Neil Nedley”Nedley”

• How to obtain CD-ROMS, presentation How to obtain CD-ROMS, presentation materials and other health materials.materials and other health materials.

• Toll Free 1-888-778-4445 or outside the Toll Free 1-888-778-4445 or outside the U.S. 580-226-8007U.S. 580-226-8007

The information contained in this

presentation may be found in