NebShair Final Presentation

8/9/2019 NebShair Final Presentation

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NebShair

D-Lab Health Spring 2010 Presents


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Problem Statement Design Focus Background

Design SpecificationsExisting Technologies

NebShairDesign OverviewPatient InterfaceDosage MonitoringGas Regulation

Initial ValidationVapor SensorPressure Regulation

EvaluationDesign issuesCost/ManufacturingImpactRegulatory PathwayMoving Forward

Presentation Overview


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Current problemsSingle userNo way of monitoring amount of drug deliveredPatient interface leads to high drug waste

Problem Statement

High incidence of respiratoryinfections in developing world

-Asthma is the most chronic diseaseaffecting children (WHO)

In Nicaragua, there is a largedemand for jet nebulizers amongst

children-Long lines and waits for use of machine

(30-40 people) for one machine


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Multi-patient

Dosage Monitoring

Design Focus


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Minimum pressure for correct size particles15 psi to 50 psi (better the more expensive)

Ensures Standard Dosage0.5 mL albuterol + 3 mL salean

Easily cleaned ModularAffordable Efficient

Background

Design Specifications/Parameters


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Existing Technologies Jet Nebulizers

Preferred method, especially for infantsand children

Vaporizes medicine using compressed air

Not breath-actuated

drug loss andpoor dosage monitoring

Vibrating Mesh 2 sieves vibrating at high frequencies to

vaporize and deposit medicine Breath-actuated State-of-the-art technology, difficult to

duplicate, and expensive

Ultrasound Ultrasonic waves break the medicine into

smaller vapors Shown to physically disintegrate the

medicine

Background


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NebShair


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Patient Interface Dosage Monitor Pressure

Regulation

NebShair Design Overview


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Multiuser system Reservoir

With multiple tubes leading to each patient Tube with its own one way valve and dosage sensor

attachment

Idea initially considering the Ultrasoundnebulizer

Created too much vapors Wanted to capture those vapors

Breath-Actuated Spring loaded one-way valve

Pressure adjusted right above threshold of thereservoir Benefits

Patient directed Better regulation of dosage No waste when children are not actively using the

machine

NebShair Patient Interface


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Vapor Sensor

Instrumentation: LED light, photodetector,Arduino

How it works: LED light sends signals to the photodetector, whichdetectsp the light. The photodetector measures voltage

drop and that is directly correlated to the amount of light

falling on its surface.

More light lower resistance lower voltage Larger drug particles more light scattered less light

falls on photodetector lower resistance lowervoltage

Arduino threshold voltage- correlates to passing medicine

vapors

Summing of signal over time to alert patient withDosage LED

NebShair Dosage Monitor

Dosage light


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One-way ValveJust below 1.5 psi for

breath-actuation

Gas Pressure SensorSenses and triggers

Solenoid ValveRedirects compressedair when triggered to

regulate pressure

NebShair Pressure Regulation


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Vapor Sensor

Initial tests Sensitivity of photodetector to

presence of vapors

Saturation of tubing withvapors and condensation effectson the LED and photodetector

Accuracy of the dosagesummation

NebShair Initial Validation

Future tests Similar tests, but mimic vapor flows by methods of

inhalations (instead of using the jet compressor to push

vapors through)

Run tests with the one-way valve (condensation)


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NebShair Initial ValidationPressure Regulation System

Initial tests Control system calibrated to keep pressure

steady (~1 psi gauge)

Tested with standardized one way valves Hardware limitations on pressure

Future tests Improve hardware to achieve higher pressure Calibrate with many 1-way valves Design custom valve


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Our two components merging into one systemSimple dimension problem

Coagulation Sterilization

Design IssuesEvaluation

Dosage light


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Evaluation

CostPrototype Cost Analysis

Price Amount Cost

Tupperware $10/part 1 part $10

LED $1/part 8 parts $8

Photoresistor $1.5/part 4 parts $6

Wire $0.39/ft 6 ft $2.34

Arduino $29/part 1 part $29

Breadboard $19.95/ 2 parts 2 parts $19.95

Gas pressure $34.25/part 1 part $34.25Solenoidvalve $8/part 1 part $8

Tubing $19.99/100ft 10 ft $2.00

Spring valve $4.00/part 4 parts $16.00

Total $136

Final- Mass ManufacturedPrice Amount Cost

Tupperware $1/part 1 part $1

LED $.50/part 8 parts $4

Photoresistor $1/part 4 parts $4

Wire $0.39/ft 6 ft $2.34

Gas pressure $10/part 1 part $10.00

Solenoid

valve $5/part 1 part $5Tubing $19.99/100ft 10 ft $2.00

Spring valve $3.00/part 4 parts $12.00

Total $40

For cost-efficiency, individual components would be manufacturedin existing infrastructure (outsourced)

Assembly would be local in-house manufacturing site

Manufacturing


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Respiratory disease rampantAsthma- 300 million people worldwide suffer

The most common chronic disease amongstchildren can be medicated!

26.20/100,000 Child death rate from respiratorydiseases

Under-dosed and long waits

ImpactEvaluation


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Nebulizer Direct PatientInterface, DeVilBiss

Compressor/Nebulizer,CAF K970289(4/15/1997)

DeVilbiss Model 5650K923888

Jet-nebulizer

Healthdyne, Inc. 323K922623 (12/1/1992)

one-way valve and filter

Regulatory Pathway- 510K and Predicate Devices

Evaluation


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Pan American Health Organization (PAHO) international public health agency recognized by the UN serves as regional office for the WHO

Duties: Medical Device Regulation Program:

Defines medical device Pre & post market approval Audit manufacturer and distributor Apply pre-market assessment controls Harmonize regulatory requirements

Regulatory Pathway- Local RegulationEvaluation


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DesignImprovements

Low-cost vibratingmesh??

Evaluation

Moving Forward

NebShair Final Presentation

Documents

Transcript of NebShair Final Presentation