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Transcript of Nba magnetic materials
Nanobioanalysis: a multidisciplinar challenge
Montserrat Rivas,
José Ángel García, José Carlos Martínez
FORC technique
SPION RF biosensor
Research environment
Universidad de Oviedo
Prof. Marcos Tejedor
Magnetism & Magnetic Materials in the University of Oviedo
NanoBioAnalysis (NBA)
Oviedo University
Universitary Central Hospital
Materials Institute
NanoBioAnalysis (NBA)
Magnetic Materials Integrated
Optics
Electrochemical sensors
Electrophoresis &
Paper-based tech
Clinical Immunology
& Microbiology
Biotechnology & Biomedical
Essays
FORC technique
SPION RF biosensor
Research environment
The FORC idea
FORC: First-Order Reversal Curves
SFD: Switching Field Distribution
𝑆𝐹𝐷 𝐻ext, 𝐻𝑟 =𝜕𝑚
𝜕𝐻ext 𝐻𝑟
FORC diagram
𝜌 = −1
2
𝜕2𝑚
𝜕𝐻𝑒𝑥𝑡𝜕𝐻𝑟
J.C. Martínez-García et al., J. Phys. D: Apl. Phys. 47 (2014) 015001
Detection of non-interacting single domain particles using first‐order reversal curve diagrams
R. Egli et al, Geochemistry, Geophysics, Geosystems 11 (2010)
FORC diagrams measured on the Lake Ely sediment sample.
Magnetic and Mössbauer Spectral Study of Core/Shell Structured Fe/Au Nanoparticles
S. J. Cho et al., Chemistry of Materials 18 (2006) 960
Set of FORCs
J.C. Martínez-García et al., J. Alloy Compd. (2014)
Set of SFDs
FORC differential dissection of soft biphase magnetic ribbons
J.C. Martínez-García et al., J. Alloy Compd. (2014)
Co nanostructures in ordered templates: comparative FORC analysis
Co array samples of (a) nanowires with diameters of 65 nm, (b) nanopillars with diameters of 60 nm, and (c) nanotubes with diameters of 65 nm.
M.P. Proenca, Nanotechnology 24 (2013) 475703
FORC technique
SPION RF biosensor
Research environment
Magnetoimpedance-based detection
Magnetoimpedance
Co70Fe5Si10B15
amorphous ribbon
Samples and methods
Test fixture ribbon to impedance analyser (1-110 MHz) + Helmholz coils (dc field)
Superparamagnetic 10 nm Fe3O4 nanoparticles (SPIONs)
NPs deposited onto blotting paper strips
NPs detection with Co (GMI)
Magnetoimpedance
Co70Fe5Si10B15
amorphous ribbon
Cu-based detection
NPs detection with Cu
NPs detection with Cu
Cu-ribbon
Co-ribbon
Printed Circuit Board
Printed Circuit Board
NPs detection with PCB1
PCB1
Cu-ribbon
x 5
Meander-line circuit
NPs detection with meander-structure
Meander
PCB1
x 3
Planar spiral-like circuit
NPs detection with spiral-sensor
PCB1
Spiral
x 7
Planar spiral-like circuit
NPs detection with 5-turn spiral
5-turns
PCB1
x 30
Origin of the detection
Changing magnetic field
Induced electromotive forces
Switching magnetic moment
Skin effect
400 mm
35
mm
Active area
Cross-section of the conductor track
Proximity effect
Cross-section of three parallel traces
A frequency-related detection
Signal versus SPION mass
PWB5S
LFT: Lateral Flow Test
Sample
Conjugated SPIONs Test line
Control line
Magnetic immunoassay
LFT/SPION rf-detection
❶
❷
❸
❹
❺
❻
❶
❻
❷
❸
❹
❺
Magnetic immunoassay
Conclusions
Electromagnetic detection of SPIONs: highly sensitive, low-cost and simple fabrication/handling.
Biosensing via nanoparticles detection
Nano Bio
Sensor
Biomarkers
NPs synthesis
Size-effects
Characterization
Biotoxins Cells
Antibodies Proteins
Biointerfacing
NanoBioAnalysis March 2012 http://grupos.uniovi.es/web/nba
Thank you for your kind attention