the next generation four modality preclinical imaging platform

nanoScan® products are No.1 in the following:

IMAGIN

G FO

R SCIENCE

Family

- achieve the breakthrough 10,000 cps/MBq SPECT sensitivity

- 275 µm SPECT resolution measured with Derenzo phantom

- 700 µm PET resolution measured with Derenzo phantom

- quantification accuracy over 97% for SPECT & PET

- in-line SPECT/MRI multimodality system

- in-line PET/MRI multimodality system

CT

MRI

SPECT PET

SPECT PET

CT

MRI

SPECT PET

Kép csere!!!

the next generation four modality pre-clinical imaging platform

SPECT/MRI, PET/MRI, SPECT/CT, PET/CT

Egész test??

2

Pursuit of perfection in technology to serve perfection in science

Always eager to find an even better solution, Mediso constantly strive to develop the highest

level medical imaging technologies possible.

We wish to serve the scientific community with our core value: supreme image quality with

quantification.

MEDISO Medical Imaging Systems

Mediso Medical Imaging Systems with headquarters in Budapest is a dynamic supplier of nuclear medicine and modern

hybrid imaging techniques to healthcare and research institutes around the world. The company was founded in 1990

by experts of the leading research and manufacturing company of the region carrying on their proficiency in developing

and producing nuclear equipment since 1960. At present Mediso continue its legacy in researching innovative medical

imaging technologies and developing cutting edge preclinical and clinical imaging systems.

www.cromedresearch.hu www.scanomed.hu (persze humán képpel)

vagy logoval? képeken még gondolkodni, hogy jól nézzen ki! szerintem több kicsi is szóba jöhet a díjaknál

Note: images should be the picture of the building and CROmed logo?

Tradition in research and development

Clinical diagnostic and CRO partners

Mediso have developed special partnership with pre-clinical imaging contract research organizations and leading

molecular imaging centers in both preclinical and clinical domain around the world.

Partnership with CROmed, Karolinska Institute, Semmelweis University in preclinical field and Scanomed, University of

Debrecen Medical School and Hungarian National Institute of Neuroscience in clinical area represent vital drive to

Mediso's developments as well as invaluable feedback and better insight into users’ needs.

Customer focused support

Mediso-affiliated subsidiaries and world-wide distributor network with strong factory support ensure close contact

with our customers and quick, professional response to their requests not only in technical but also in application

related issues. We at Mediso are proud to serve physicians and researchers at more than 100 preclinical and 900 clinical

system installations in 86 countries.

Some awards and partners:

www.cromedresearch.com www.scanomed.hu

Latest awards

New Product Innovation Award

2011 - Grand Prize of Innovation 2010

2008 - Frost & Sullivan 2008 European Medical Imaging

Entrepreneurial Company of the Year Award

2006 - Grand Prize of Innovation 2006

2012 - Frost & Sullivan 2012 European Preclinical Imaging

Customerfocusedfactorysupport

Improvedimaging

performance

Increasedproduct

variability

100% customer satisfaction for all usersnanoScan®

3®*NanoSPECT/CT

Various upgrade opportunities for existing *NanoSPECT/CT® users

SPECT PET

CT

MRI

Imaging facilities already using the world market leader *NanoSPECT/CT systems (manufactured by Mediso) - to be

able to keep up with the pace of development of technology (like the nanoScan Family) - are provided with the

unique opportunity of upgrading onto the next level of multi-modality imaging.

® TM*NanoSPECT/CT and NanoPET/CT are registered U.S. trademarks of Bioscan, Inc., which does not sponsor, authorize or endorse this site or any of

MEDISO’s services or goods. There is no affiliation or relationship between Bioscan, Inc. and MEDISO.

®

®

Unique versatility in molecular imaging modalities

SPECT PET

CT

MRIMembers of the nanoScan® Family combine the industry’s highest performing microscopy

level of NM imaging supported by excellent MRI and CT performance.

The ultimate versatility and in-line combinations of the systems are based on common

software, common animal handling platform and easy on-site upgrade possibility, thus

fulfil all demands of your growing and long term research requirements.

nanoScan® - the four modality in vivo molecular imaging platform

With the

with shared components and flexible upgrade possibilities. Exclusive features only from the Mediso :

nanoScan® Family Mediso designed a platform that can satisfy the increasing needs of any research institute

nanoScan® Family

Benefits of joining the nanoScan® Family:

TM- New patented* Tera-Tomo 3D SPECT on the fly

Monte Carlo based multi-pinhole reconstruction

- Improved SPECT quantification accuracy by scatter and

CT based attenuation correction

- List-mode SPECT acquisition and processing for heart,

brain and other applications

- New patented** non-multiplexed M pinhole apertures

for artifact-free imaging

*

3 TM

Family concept

- Two MRI and two CT based bimodal solutions

- Highest visible resolution in NM modalities: 275 µm SPECT and 700 µm PET

- Highest PET and SPECT quantification accuracy: over 97% in both modalities

- Dynamic list mode acquisition for both PET and SPECT

- Fulfiling low to high budget requirements with continuous on-site upgrade path

- Worldwide exclusive factory support throughout the equipment lifetime (guaranteed for moreTM

than 10 years for all systems including NanoSPECT/CT and NanoPET /CT)®

UP

GR

AD

E

* patent pending*

Family

- 30 µm resolution- 80 W X-ray power- ultra low dose acquisition protocol

- 100 µm resolution- 500 mT/M gradient- maintenance free magnet

- 275 µm visible resolution- over 97% quantification accuracy- up to 10,000 cps/MBq sensitivity by 100 pinholes

SPECT

MRI*

CT

SPECT PET

CT

MRI

nanoScan® SPECT/CT

nanoScan® SPECT/MRI

4

1

5

6

7

8

nanoScan® PET/MRI

nanoScan® PET/CT

PET

SPECT PET

CT

MRI

- 700 µm visible resolution- over 97% quantification accuracy- 9% maximal sensitivity

5

Common Versatile Platform

2

3

4

1. MRIMRI of a 30 g Nu/Nu mouse with flank tumor xenograft imaged post i.v. injection of iron oxide particulate contrast agent using a T1-weighted GRE sequence, imaging duration 6.5 min.

2. PET/MRI18F-FDG PET in a 30 g Nu/Nu mouse with flank tumor xenograft imaged in the last 10 minute frame of a 60 min. dynamic scan post i.v. injection of 4 MBq of radioactivity. MRI acquisition details as in image 1.

3. PET18F-FDG biodistribution image in a 32 g mouse during a 5 minute scan, immediately after i.v. injection of 3.4 MBq of radioactivity. Vascular system is visible.

4. PET/CTGated cardiac PET/CT image of a 14 g Balb/c mouse

18injected with 6.7 MBq of F-FDG. 20 min. gated PET acquisition immediately post injection, heart rate was over 500 bpm. CT acquired with 55 kVp during 9 min. with real-time reconstruction.

5. CT440 g Wistar rat, injected with a total of 6 mL of Visipaque human clinical X-ray contrast agent during continuous i.v. infusion, CT scan with 45 kVp, total CT duration 13.5 min. using real-time reconstruction.

6. SPECT/CT23 g Nu/Nu mouse, injected with 45.5 MBq

99mof Tc-Human Serum Albumin imaged for 30 minutes in SPECT 10 min. post injection. CT scan with 45 kVp, total CT duration 7.5 min. using real-time reconstruction.

7. SPECT347 g Wistar rat, injected with 68.6 MBq of 99mTc-Human Serum Albumin, imaged for 60 minutes in SPECT 5 minutes post injection.

8. SPECT/MRITransaxial plane view of 34 g mouse brain, injected

123with 7.4 MBq of I-NNC13-82431 compound, imaged for 30 minutes, 3h post injection. MRI acquisition: T2 weighted FSE.

1., 2. Images courtesy of Helmholtz-ZentrumDresden-Rossendorf. 3., 4., 5., 6., 7., 8. Images courtesy of CROmed Ltd.

Cover page: SPECT/MRI, SPECT/CT images courtesy of CROmed Ltd., PET/CT image courtesy of Helmholtz-Zentrum Dresden-Rossendorf, PET/MRI image courtesy of Karolinska Institute

nanoScan® SPECT/CT/PET

TM*M2 MRI from Aspect Imaging

6

Shared components

TMNucline 2.0 - all modality acquisition software

- Common user friendly acquisition platform for all four modalities

- Integrates wide range of functionalities of acquisition,

calibration, data management, reconstruction and

visualization.

- DICOM standard images stored in DICOM server

- Flexible and easily customizable daily workflow protocols.

- Software solutions

TMInterView FUSION - post processing and analysing software

- Supports DICOM, Analyze 7.5, RAW import/export as

well as exporting still images (DICOM SC, JPEG, PNG)

and movies (AVI)

- Supports dual, triple and quadruple fusion of

PET/SPECT/MRI/CT images

- Provides GPU accelerated 3D MIP, Volume Rendering

and Surface Rendering Techniques.

- Multiple statistics of Time Activity Curve (TAC) can be

derived from 4D dynamic PET and SPECT studies

(with MS Excel compatible export)

TMTera-Tomo 3D SPECT / PET - reconstruction software

- Multi GPU based data reconstruction with multi-Teraflop Computing

- Wide range of corrections such as detector geometry, Monte Carlo DOI estimation, object attenuation

and scatter, randoms, dead time and partial volume.

- Results are ultra-fast, quantitative and provide excellent visual quality reconstructed images.

TMTera-Tomo 3D SPECT reconstruction principle

with on the fly system matrix generation

position dependentintrinsic resolution

PSF model

Monte Carlodetector

crystal model

realistic pinholecollimatorsimulation

attenuation andscatter within

the object

GPU-basedadvanced 2D

and 3D filtering

TMTera-Tomo 3D SPECT reconstruction principle

with on the fly system matrix generation

Monte Carloattenuation &

scatter correction

Monte Carlopinhole

modeling

Regularizediterative

reconstructioncycle

Multi-GPU3D iterative

reconstruction

TMTera-Tomo 3D SPECT reconstruction principle

with on the fly system matrix generation

Photon transport modeling

(attenuation, scatter)

Monte Carlobased pinhole

edge penetration modeling

Monte Carlobased crystalinteractionmodeling

Regularized OSEMreconstructionimplemented on multi GPU

High precision, quantitative,fast 3D SPECTreconstruction

PSF-based intrinsic

resolution modeling

Releasebutton

Automatic disattachment

7

Data Workflow / Workstations

head positioning by ear bars

inhalation through tooth bar

anesthesia gas absorption by nose cone

respiratory gating by breath sensor

temperature control by integrated hot-air channels

- Multimodality imaging for

- Multipurpose applications 4D-, 5D

imaging by one-click connection

PET+CT+SPECT+MRI modalities (full compatibility)

MultiCell™ Imaging bed

- Multiple mouse scanning in one scan

(optional)

- Multifunctioning preparation station

for the imaging cells

TMMultiCell Animal Anesthesia / Imaging Chamber

Control / Equipment Room

Multimodality Acquisition / Processing Workstations

Multimodal image visualization

Post processing features after acquisition

DICOM 3.0 and CFR21 part 11 compliant

data handling

PET/CT acquisition and control

NuclineMain Console WS

TM

Tera-Tomo - Real 3D Reconstruction WS

TM

PET

Dual monitor WS with touchscreen

- Intel® Core™ i7 platform @ 3.4 GHz

- Non-stop operating WS through liquid cooling

- Safe data handling by 0,5 TB SSD

- GPU based on the fly volume rendering

- Ease of use CT scout for positioning

- 24” + 17” (on the gantry) LCD monitor

- Multitask 64 bit OS by MS Windows 7

- Intel® Core™ i7 platform up to 4.5 GHz

- Cutting edge computing with liquid cooling

- Safe raw data backup by 0.5 TB SSD

- GPU cluster with 6 GB memory

- Mainstream data transfer through dual 10 GbE

- Realtime 64 bit OS by Linux

PET real-time 3D reconstruction

On the fly system matrix generation

Real time image correction

Post-reconstruction image manipulation

after acquisition

1/10 Gb Ethernet

Supercomputer with embedded

Teraflop Computing

10 Gb Ethernet

Acquisition / Processing WSTM- Nucline

TM- Tera-Tomo 3D SPECTTM- Tera-Tomo Real time CT

- InterViewTM FUSION

Post-processing WSTM - InterView FUSION

TM- Tera-Tomo 3D SPECT

Post CT

- Online archiving

TM- Tera-Tomo

TMTera-Tomo 3D PET - Real WS

TMTera-Tomo 3D PET

„real“ reconstruction

TMTera-Tomo 3D PET

„post“ reconstruction

Win

do

ws

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ECT

/ M

RI /

CT

mo

dal

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Linux

bas

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odal

ity

Real time acquisition /Processing /

reconstruction unit

Post-processing /reconstruction /archiving unit

- Multimodality imaging for

- Multipurpose 4D, 5D imaging by one-click connection

- Multiple mouse imaging in one scan (optional)

- Multifunction preparation station for the imaging cells

PET+CT+SPECT+MRI modalities (full compatibility)

applications

TMTera-Tomo 3D PET - Post WS

SZÉLES!!!

Conformance Statement

Product design, development, production and services comply with ISO 9001:2001 and with ISO 13485:2004.

The nanoScan® multimodality molecular imaging system conforms to EC Directive 93/42/EEC; Annex II, Article 3 Full Quality Assurance

System Medical Devices Design and safety testing has been performed in accordance with IEC 60601-1 and IEC 60601-1-2 EMC standards.

Safety labels are attached to appropriate places on equipment and appear in all operation manuals. The supplied software conforms to DICOM and CFR 21 part 11 standard.

The technical information provided here is not a detailed specification.

For exact details and up to date information please contact your local distributor or Mediso Medical Imaging Systems.

MEDISO Medical Imaging Systems

1022 Budapest, Alsótörökvész 14. Hungary

Phone.: +36-1-399-3030

Fax.: +36-1-399-3040

E-mail: info@mediso.com

Web: www.mediso.com

MEDISO reserves the right to change data without notice © MEDISO 2013. NSFB 08/13

®nanoScan is registered trademark of MEDISO Medical Imaging Systems.

TM TM TM TM TMNucline , InterView FUSION, Tera-Tomo 3D PET, MultiCell , PrepaCell are trademarks of MEDISO

Medical Imaging Systems.

TMcore i7 is trademark of Intel.

®

Windows is registered trademark of Microsoft.

®

NanoSPECT/CT is registered trademark of BIOSCAN.

TMCUDA is trademark of NVIDIA. This product was partially established by the support of the National Development Agency of Hungary

using funds of the Research and Technology Fund (code: TeraTomo).

More than 100 pre-clinical and 900 clinical MEDISO manufactured systems were installed worldwide

86 countries100+ preclinical systems900+ clinical systems

Worldwide installed base of preclinical and clinical systems developed and manufactured by Mediso

Conformance Statement

Quality management system operated by Mediso Medical Imaging Systems complies with Council Directive 93/42/EEC Annex II.

Product design, development, production and services comply with EN ISO 13485 and EN ISO 14971.

Safety labels are attached to appropriate places on equipment and appear in all operation manuals.

The supplied software complies with DICOM standard.

The technical information provided here is not a detailed specification.

For details and up to date information please contact your local distributor or Mediso Medical Imaging Systems.

Trademarks:

is registered trademark of MEDISO Medical Imaging Systems.

TM TM TM 3 TM TM TMNucline , InterView FUSION, Tera-Tomo 3D, M pinhole , MultiCell , PrepaCell are trademarks of MEDISO Medical Imaging Systems.

®nanoScan

®TMNanoPET /CT is trademark, NanoSPECT/CT is registered trademark of Bioscan.