Nanomedicines for imaging and drug deliveryActivities of the BioNanoMaterials group

Jessica RosenholmProfessor in Pharmaceutical DevelopmentPharmaceutical Sciences LaboratoryÅbo Akademi University, Turku, Finland

Nanomedicine

”The application of nanotechnology to health”

Three scientific areas recognized by the ETP for

Nanomedicine:

1) Nanopharmaceutic(al)s (drug delivery systems...)

2) Nano-diagnostics (in vitro POC devices, in vivo

contrast agents...)

3) Regenerative medicine (tissue engineering,

stem cell therapy...)

theranostic agents

*) theranostics: simultaneous imaging and therapy enabling follow-up of the drug delivery process

19.1.2017 3Åbo Akademi University | Domkyrkotorget 3 | 20500 Åbo | Finland

Nanopharmaceuticals

Spatial control (targeting)Temporal control (drug release)

• Therapeutically active compounds:

• hydrophobic drugs, hydrophilicdrugs, biomolecules (e.g. peptides, proteins, nucleic acids)

• Sustained or controlled release

• Targeted drug delivery in vitro and in vivo (passive and active)

19.1.2017 4Åbo Akademi University | Domkyrkotorget 3 | 20500 Åbo | Finland

Nanodiagnostics

NPs as carriers for imaging agentsInherently detectable NPs

• Optically active materials:

• Carbon nanostructurs(nanodiamonds, carbon dots)

• UCNPs (upconvertingnanophosphors)

• Magnetically active materials:

• Iron oxides, Fe3O4 (SPIONs)

• Other metal oxides, MnO, Gd2O3

• NPs as carriers for molecularimaging agents

• Fluorophores (opt), rare earthmetal complexes (opt & mag)

Combined core activity & shell loading capacity: core@shell designs

Antibacterial”nanobiotics”

Theranosticnanomedicines

3D: Biofunctional scaffolds with cell-directed drug delivery for

tissue regeneration

2D: Personalized drug dosing

Printing of drug-loaded NPs as a nano-ink with a piezoelectric inkjet printer

Individualized dosing of poorlysoluble drugs

Sustained/controlled release

3D printed scaffolds providing stem cell guiding tools

Individually tailored structures combined with NPs for cell directed drug delivery

Printing of nanomedicines

The main objectives of the research group are to:

Develop mesoporous silica nanoparticle (MSN) based nanoformulations suitable for a broad range of cargo, e.g. drugs/biomolecules/imaging agents/sensor dyes…

Synthesize multifunctional composite nanostructures for improved bio-visibility (detectability in biological systems) and theranostic activity

Evaluate the potential and applicability of the developed nanomedical agents for in vitro and in vivo drug delivery and biomedical imaging together with our cross-disciplinary collaborators

Summary of activities of the BNM group

Novel materialsdevelopment

Nanoformulationdrugs/biomolecules/ diagnostic agents…

Evaluation of applicability

Flexible particle

design and wide

application areas