Nanobiotecnologie Nanotubi di carbonio
Transcript of Nanobiotecnologie Nanotubi di carbonio
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Nanotubi di carbonioNanobiotecnologie
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Nanotubi di carbonio: sintesiNanobiotecnologie
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CNT properties: electronic
Valence band
Conduction band
Semiconductor
MetallicAllowed states for a 3,3 SWNT
The unique electrical properties of SWCNTs arise from the confinement of the electrons in CNTs, which allows motion in only two directions along the tube axis: forward and backward.Metallic CNTs can carry enormous current densities up to 109 A/cm2 without being destroyed.Semiconductoror nanotubes have excellent properties for the construction of field effect transistors.
Nanobiotecnologie
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CNT properties: mechanical
• C-C sp2 bonds• few defects
• tensile strength• elastic modulus
Nanobiotecnologie
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• NIR absorption• NIR luminescence• NIR Raman scattering
CNT properties: mechanicalNanobiotecnologie
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CNT are insoluble in any solvent and tend to form bundle aggregates (high surface area maximum dispersion and hydrophobic interaction)
CNT properties: functionalization
Covalent (walls)Covalent (defects)
Non-covalent (stacking)
Non-covalent (polymer wrapping)
Non-covalent (encapsulation)
Nanobiotecnologie
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CNT properties: functionalization
Defect creation:oxidation
Walls functionalization:Addition reactions
Nanobiotecnologie
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Nanobiotech con i nanotubiCaratteristiche dei nanotubi: • Nanostruttura 1D, flessibile e robusta, diversa dalle nanoparticelle
• Tutti gli atomi sulla superficie
• Conduttivi
• Assorbimento NIR
• Emissione NIR
• Scattering Raman
Nanobiotecnologie
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Drug deliveryFunzionalizzazione covalente
• No tossicità.• Uptake energy-independant.• Gene transfection.
Nanobiotecnologie
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Drug deliveryFunzionalizzazione covalente
• Antifungino• Uptake energy-independant.• Attività superiore al farmaco.
Anfotericina B
Nanobiotecnologie
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Drug deliveryFunzionalizzazione covalente
• Vaccino• Non altera la funzinalità dell’antigene• Stimola la produzione di anticorpi.
Anfotericina BRiconoscimento da parte dell’anticorpo
Immunizzazione
Nanobiotecnologie
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Drug deliveryFunzionalizzazione non-covalente
Nanobiotecnologie
Phospholipids
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Drug deliveryFunzionalizzazione non-covalente
Doxorubicina
Loading
ReleaseAFM
Targeting peptide
Nanobiotecnologie
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Drug deliveryFunzionalizzazione non-covalente
Riduzione della massa tumorale
chemioterapico
Nanobiotecnologie
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Drug deliveryFunzionalizzazione mista
Nanobiotecnologie
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Drug deliveryFunzionalizzazione mista
Nanobiotecnologie
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Drug deliveryFunzionalizzazione mista
Nanobiotecnologie
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PET imagingAgente di targeting
Nanobiotecnologie
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Raman imaging
Nanotubi con diversa composizione Isotopica producono diversi scatteringRaman: è possibile ettichettare le cellule.
Nanobiotecnologie
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Raman and photoacustic imagingNanobiotecnologie
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Interfacce neuraliI nanotubi favoriscono e orientano la crescita dei neuriti
Cellule neuronali cresciute su un letto di nanotubi orientati
Letto di nanotubi purificati
Nanobiotecnologie
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Interfacce neuraliI nanotubi favoriscono la comunicazione elettrica tra i neuroni
glass
CNT
Nanobiotecnologie
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Interfacce neuraliI nanotubi favoriscono la comunicazione elettrica tra i neuroni
Nanobiotecnologie
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Interfacce neuraliI nanotubi favoriscono la comunicazione elettrica tra i neuroni
Nanobiotecnologie
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Nanobiotecnologie
Interfacce neuraliI nanotubi migliorano la performance neuronale