Nano machines
-
Upload
clifford-stone -
Category
Documents
-
view
101 -
download
3
Transcript of Nano machines
![Page 1: Nano machines](https://reader033.fdocuments.in/reader033/viewer/2022052621/557da8c3d8b42a642d8b51f6/html5/thumbnails/1.jpg)
1
PROTEIN BASED NANO MACHINES FOR SPACE
APPLICATIONS
Dr. Constantinos Mavroidis, Associate Professor
Department of Mechanical and Aerospace Engineering
Rutgers, The State University of New JerseyNIAC Phase I GrantNIAC Phase I Grant
![Page 2: Nano machines](https://reader033.fdocuments.in/reader033/viewer/2022052621/557da8c3d8b42a642d8b51f6/html5/thumbnails/2.jpg)
2
THE TEAM
Dr. C. MavroidisAssociate Professor Mechanical Engineering, Rutgers University
Dr. M. YarmushChair, Biomedical Engineering, Rutgers University
Dr. M. S. TomassoneAssistant Professor, Biochemical Engineering Rutgers University
Dr. F. PapadimitrakopoulosAssociate Professor Department of Chemistry University of Connecticut
Dr. B. YurkeResearcher, Bell Laboratories, Lucent Technologies Inc.
Mr. Atul DubeyGraduate Student Rutgers University
Ms. Angela ThorntonGraduate Student Rutgers University
Mr. Kevin NikitczukUndergraduate Student Rutgers University
![Page 3: Nano machines](https://reader033.fdocuments.in/reader033/viewer/2022052621/557da8c3d8b42a642d8b51f6/html5/thumbnails/3.jpg)
3
OUR VISIONTo Develop Protein Based To Develop Protein Based NanoNano Machines and RobotsMachines and Robots
NovelNovelBiologicalBiologicalMultiMulti--Degree of FreedomDegree of FreedomApplyApply Forces Forces Manipulate Objects Manipulate Objects Move From Move From NanoNano to Macroto MacroLightweight / EfficientLightweight / EfficientSelfSelf--AssemblingAssemblingSelfSelf--ReproducingReproducing
![Page 4: Nano machines](https://reader033.fdocuments.in/reader033/viewer/2022052621/557da8c3d8b42a642d8b51f6/html5/thumbnails/4.jpg)
4
APPLICATIONS
Outer Outer SpaceSpace and Planetary Missionsand Planetary Missions
Colonization
Workstations
Military
Medical
Manufacturing
![Page 5: Nano machines](https://reader033.fdocuments.in/reader033/viewer/2022052621/557da8c3d8b42a642d8b51f6/html5/thumbnails/5.jpg)
5
APPLICATIONS
Bio-Nano-Robot Repairing a Damaged Blood Cell
![Page 6: Nano machines](https://reader033.fdocuments.in/reader033/viewer/2022052621/557da8c3d8b42a642d8b51f6/html5/thumbnails/6.jpg)
6
0-10 YEARS: DEVELOPMENT OF BIO NANO COMPONENTS
DNA VPL Motor Bacteriorhodopsin
DNA – Structural Member, Power Source
VPL – Protein Based Actuator
Bacteriorhodopsin, HSF – Nano Sensors
![Page 7: Nano machines](https://reader033.fdocuments.in/reader033/viewer/2022052621/557da8c3d8b42a642d8b51f6/html5/thumbnails/7.jpg)
7
MACRO-NANO EQUIVALENCEStructural Elements
Metal, Plastic Polymer DNA, Nanotubes
Power Sources
Electric Motors, Pneumatic Actuators, Smart Materials, Batteries, etc.
ATPase, VPL Motor, DNA
![Page 8: Nano machines](https://reader033.fdocuments.in/reader033/viewer/2022052621/557da8c3d8b42a642d8b51f6/html5/thumbnails/8.jpg)
8
MACRO-NANO EQUIVALENCE
Compliance DevicesSprings
Various Types of Gears, Belts, Chains etc.
VPL Platforms, DNA Double Crossover Molecules
β-Sheets
Transmission Elements
![Page 9: Nano machines](https://reader033.fdocuments.in/reader033/viewer/2022052621/557da8c3d8b42a642d8b51f6/html5/thumbnails/9.jpg)
9
MACRO-NANO EQUIVALENCE
Sensors
Light sensors, force sensors, position sensors, temperature sensors
Actuated Joints
Revolute, Prismatic, Spherical Joints etc.
DNA Nanodevices,Nanojoints
Rhodopsin, Heat Shock Factor
![Page 10: Nano machines](https://reader033.fdocuments.in/reader033/viewer/2022052621/557da8c3d8b42a642d8b51f6/html5/thumbnails/10.jpg)
10
10-20 YRS: NANOROBOTIC ASSEMBLIES
ATPase Motor Propelled
Structure – Nanotubes
Legs – Helical Proteins
Vision of a Nano Robot
![Page 11: Nano machines](https://reader033.fdocuments.in/reader033/viewer/2022052621/557da8c3d8b42a642d8b51f6/html5/thumbnails/11.jpg)
11
20-30 YRS – SELF SUSTAINMENT AND REPLICATION
Self Replication SustainmentSwarm IntelligenceControllability
![Page 12: Nano machines](https://reader033.fdocuments.in/reader033/viewer/2022052621/557da8c3d8b42a642d8b51f6/html5/thumbnails/12.jpg)
12
30-50 YRS – DEPLOYMENT FOR SPACE COLONIZATION
Courtesy: http://members.cox.net/kableguy/bryceworks/
Space Colonization
Non-living Robots
Bio Mimetic
Remote Sensing
Signal Transmission
![Page 13: Nano machines](https://reader033.fdocuments.in/reader033/viewer/2022052621/557da8c3d8b42a642d8b51f6/html5/thumbnails/13.jpg)
13
SPECIFIC AIMS FOR PHASE I
Identify Proteins for Use in Nanoscale MechanismsIdentify Proteins for Use in Nanoscale Mechanisms
Develop Concepts for Bio Develop Concepts for Bio NanoNano Machine componentsMachine components
Develop Dynamic Models and Realistic SimulationsDevelop Dynamic Models and Realistic Simulations
Perform a Series of Biomolecular ExperimentsPerform a Series of Biomolecular Experiments
Assembly and Interface Assembly and Interface NanoNano Machine ComponentsMachine Components
![Page 14: Nano machines](https://reader033.fdocuments.in/reader033/viewer/2022052621/557da8c3d8b42a642d8b51f6/html5/thumbnails/14.jpg)
14
VPL MOTOR CONCEPT
Viral Membrane Peptides
pH Dependent
![Page 15: Nano machines](https://reader033.fdocuments.in/reader033/viewer/2022052621/557da8c3d8b42a642d8b51f6/html5/thumbnails/15.jpg)
15
VPL ACTUATED PLATFORMS
Viral Protein Linear Motor Actuated Parallel Platforms with Controllable Motion
![Page 16: Nano machines](https://reader033.fdocuments.in/reader033/viewer/2022052621/557da8c3d8b42a642d8b51f6/html5/thumbnails/16.jpg)
16
VPL OUTPUT MULTIPLICATION
VPL Motors in Parallel –Force Multiplication
VPL Motors in Series –Displacement Multiplication
![Page 17: Nano machines](https://reader033.fdocuments.in/reader033/viewer/2022052621/557da8c3d8b42a642d8b51f6/html5/thumbnails/17.jpg)
17
BIOSENSOR SYSTEM
HSF Protein in Organisms
Responds to Stimuli – Trimerises
Binds to DNA
Color Change
Signal Transmission
![Page 18: Nano machines](https://reader033.fdocuments.in/reader033/viewer/2022052621/557da8c3d8b42a642d8b51f6/html5/thumbnails/18.jpg)
18
MULTI- DOF DEVICES
3 VPL Actuators
Nanotubes
DNA Joints
Response to pH Changes
![Page 19: Nano machines](https://reader033.fdocuments.in/reader033/viewer/2022052621/557da8c3d8b42a642d8b51f6/html5/thumbnails/19.jpg)
19
COMPUTATIONAL STUDIESModel Reversible Folding of VPL Motor Protein
Estimate Forces, Displacements etc. Through Energy
Software Usage - CHARMM
Input – Structure Files in .pdb Format
Output – Simulated Energy and Displacements
Microsecond Modeling – Assumptions, Targeted MD
Parallel Processing Facilities at CAIP (Teal)
Comparison with Experimental Observations
![Page 20: Nano machines](https://reader033.fdocuments.in/reader033/viewer/2022052621/557da8c3d8b42a642d8b51f6/html5/thumbnails/20.jpg)
20
EXPERIMENTAL WORK
Peptide Selection
Protein ExpressionProtein PurificationProtein Conformation as a Function of pH Calculate Force Expended upon ExtensionReversibilityDifferent Sequence - Different Designs
![Page 21: Nano machines](https://reader033.fdocuments.in/reader033/viewer/2022052621/557da8c3d8b42a642d8b51f6/html5/thumbnails/21.jpg)
21
WEBPAGE
http://bionano.rutgers.edu
![Page 22: Nano machines](https://reader033.fdocuments.in/reader033/viewer/2022052621/557da8c3d8b42a642d8b51f6/html5/thumbnails/22.jpg)
22
![Page 23: Nano machines](https://reader033.fdocuments.in/reader033/viewer/2022052621/557da8c3d8b42a642d8b51f6/html5/thumbnails/23.jpg)
23
OUTREACH ACTIVITIES
High School Students in Research
Minority Students in Research
Undergraduate Students Employed
Technology Transfer
International and Industry Collaboration
Colloquiums, Symposia and Journal Clubs
Interdepartmental Course on Bio Nano Technology
![Page 24: Nano machines](https://reader033.fdocuments.in/reader033/viewer/2022052621/557da8c3d8b42a642d8b51f6/html5/thumbnails/24.jpg)
24
ACKNOWLEDGEMENTS
NASA Institute of Advanced Concepts (NIAC)SROA Program and Rutgers University, NJNSF Nanomanufacturing Program