Nan M. Laird March 2019 Curriculum Vitae Date of Birth: September 18, 1943 Office Address: Home Address: Department of Biostatistics 156 Hancock Street Harvard T.H. Chan School of Public Health Cambridge, MA 02139 677 Huntington Avenue Tel: (617) 864-6379 Boston, MA 02115 Tel: (617) 432-1056 Email: laird@hsph.harvard.edu Degrees 1975 Ph.D. Statistics Harvard University 1969 B.S. Statistics University of Georgia Member, Phi Beta Kappa, Pi Delta Phi, Phi Kappa Phi Positions Present 2019-Present Harvey V. Fineberg Professor of Biostatistics (Emerita) Harvard T.H. Chan School of Public Health Other Academic Appointments and Positions 2015-2019 Harvey V. Fineberg Research Professor of Biostatistics, HSPH 2011-2015 Harvey V. Fineberg Professor of Biostatistics,HSPH 1986-2015 Professor, Department of Biostatistics, HSPH 2006-2014 Associate Member, Broad Institute of MIT and Harvard 1991-1999 Henry Pickering Walcott Professor of Biostatistics HSPH 1990-1999 Chair, Department of Biostatistics HSPH 1982-1986 Associate Professor, Department of Biostatistics HSPH 1975-1985 Member, Center for the Analysis of Health Practices HSPH Spring 1980 Senior Visiting Research Associate, Department of Statistics University of Lancaster, England 1975-1981 Assistant Professor, Department of Statistics Harvard University1975-1975-1982 Assistant Professor, Department of Biotatistics HSPH Honors 1983 Fellow, American Statistical Association 1985 Elected Member, International Statistical Institute 1991 Fellow, American Association for the Advancement of Science 1991 Special Invited Speaker, Institute of Mathematical Statistics

1992 Fellow, Institute of Mathematical Statistics 1993 Charles Odoroff Memorial Lecturer, University of Rochester 1995 Statistician of the Year, Boston Chapter of the American Statistical Association 1996 F.N. David Award, American Statistical Association 2001 Janet Norwood Prize, American Statistical Association 2003 Myra Samuels Invited Lecturer, Purdue University 2004 Donna Brogan Invited Lecturer, Emory University, 2008 2006 George Challis Award, Dept. of Statistics, University of Florida 2008 Duke University Distinguished Lecturer 2011 Distinguished Speaker, Distinguished Women Scholars in Statistics University of Buffalo 2011 Samuel S. Wilks Award, American Statistical Association 2011 Twenty-fifth Annual Lowell Reed Lecturer, American Public Health Association 2015 Marvin Zelen Award for Leadership in the Statistical Sciences 2015 Fong and Eric Clow Endowed Harvard School of Public Health Scholarship in Nan Laird’s Honor 2015 Thirtieth Anniversary Celebration of ‘DerSimonian and Laird’ Publication, Irish and British Biometrics Society, London 2016 Statistician of the Year, Chicago Chapter of the American Statistical Association Academic Service on Panels, Advisory or Editorial Boards: 1980-1982 American Statistician, Editorial Board 1980-1983 Journal of the American Statistical Association, Editorial Board 1979-1981 Member, Regional Advisory Board, Biometrics Society 1984-1985 Member, Working Group on Comparative Evaluation of Longitudinal Data, Social Science Research Council 1984-1986 Member, Visiting Lecture Program, American Statistical Association 1985-1986 Member, Office of Technology Assessment Advisory Board on Determining Mutation Frequencies in Human Beings 1985-1986 Member, National Academy of Sciences Committee on Cabin Air Quality 1985-1988 Member, Committee on National Statistics, National Research Council, National Academy of Sciences 1985-1988 Member, Advisory Board, National Liver Transplantation Data Base, National Institutes of Health 1985 Participant, Workshop on Selecting Control Groups for Nonrandomized Evaluation Studies, National Research Council, Board on Toxicology and Environmental Health Hazards 1986-1988 Data Monitoring Group, National Growth and Health Study (NHLBI) 1987-1988 Member, National Academy of Sciences Panel on NSF Scientific and Technical Personnel Data Systems 1988 Member, Radon Measurement Subcommittee, Radon Advisory Committee, EPA 1988 Member, National Academy of Sciences Panel on Evaluating AIDS Interventions

1988-1991 Member, Publication Advisory Committee for Journal of the American Statistical Association 1990-1991 Member, Committee to Evaluate the Carcinogenic Risk from EMF, EPA Science Advisory Board 1991-1993 Board of Trustees, National Institute of Statistical Sciences 1992-1993 Council Delegate, AAAS Section on Statistics 1992-1995 Member, Special Invited Papers Committee of the Institute of Mathematical Statistics 1993-1997 ENAR Representative to the President's Award Committee for the Committee of Presidents of Statistical Societies 1993-1996 Member, External Monitoring Committee for the Clinical Trial on Morbidity and Mortality in Hemodialysis Patients, NIDDK 1997 Chair, Ad Hoc Committee to Review Department of Biostatistics, Columbia University Reviewer 1997 Member, NIH Special Study Section for Statistics 1998-2001 Member, Data Safety Monitoring Board, VA Olanzapine Study 2000 Member, Special Review Panel, STAR Clinical Trial 2001 Member, Data Safety Monitoring Board, PEARL Study 2002-2010 Member, Scientific Advisory Committee for “Human Genetic Resources Analysis”, Case Western University 2002- 2007 Member, Editorial Board, Annals of Human Genetics 2004 Member, Committee on Rema Lapouse Award 2004, American Public Health Association 2004-2010 Member, Advisory Board, University of Southern California Children’s Health Study 2007 Member, Review Panel, Behavior, Environment and Genetics Section, NIMH 2010 Member, Review Panel, Department of Human Genetics, UCLA 2012-2014 Member, Review Panel, Charles A. Krug Trust Fellowship Awards, Boston MA 2015-2018 Member, NRC Panel to Review Interventions for the Prevention of Alzheimers’ Disease Grants and Awards (as Principal Investigator): 1981-1983 Mellon Foundation Faculty Development Grant. 1981-1984 Grant Award from the National Institute of General Medical Sciences: “Random Effects Model for Longitudinal Studies.” 1984-1990 Grant Award from the National Science Foundation: “Empirical Bayes Approaches for Multiparameter Estimation Problems.” 1990-1992 Grant Award from the National Science Foundation: “Model Based Methods for Non-Ignorable Nonresponse in Sample Surveys.” 1984-2000 Grant Award from the National Institute of General Medical Studies: “Statistical Methods for Longitudinal Studies”

(Continuation of the preceding NIGMS award). 1996-2008 Grant Award from the National Institutes of Mental Health: “Analysis of Multiple Informant Data in Psychiatry.” 2000-2005 Grant Award from the National Heart, Lung, and Blood Institute (Subcontract) ‘Fine Mapping of Chromosome 12Q for Asthma in CAMP .’ 2003-2008 Grant Award from the National Institute of Mental Health (Subcontract): ‘Genetic Determinants of Bipolar Disorder.’ 1998-2010 Grant Award from the National Institutes of MentalHealth: ‘Family Based Tests of Association in Complex Disease.’ 2003-2010 Grant Award from the National Institutes of Health (Subcontract): ‘COPD Fine Mapping.’ 2007-2011 Grant Award from the National Institutes of Health (Subcontract): ‘Genetic Determinants of COPD’ 2012-2017 Grant Award from the National Institutes of Health (Subcontract): ‘Genetic Epidemiology of COPD’ 2011-2016 Grant Award from the National Institutes of Health (Subcontract): ‘Functional Genetics of COPD’ 2008-2013 Grant Award from the National Institute of Mental Health (Subcontract): “Rapid Ascertainment of Schizophrenia Families” 2013 Grant Award from the National Institute of Mental Health (Subcontract): ‘Novel Statistical Methods for Sequencing Data and Applications to Autism’ Academic Consultations: 1995-2009 Sterling County Study, MGH 2007- Genetics of Schizophrenia, BiPolar and Depression 2008- A Longitudinal Cohort Study of Eating Disorders in Adolescents 2000- Development of Software for FBAT-EXACT Legal and Other Consultations: 1994 Patterson Belknap representing Johnson&Johnson Expert Witness in litigation involving Tylenol (J&J) vs Excedrin (Bristol Meyers Squibb) Consultant for dispute involving Amgen (Epogen) vs Ortho/J&J (Procrit) 1995 Patterson Belknap representing Schering-Plough Consultant on NDA for Eulexin 1995 Patterson Belknap representing Johnson&Johnson Expert Witness for involving McNeil/J&J and Pepcid AC vs TUMS ll (GlaxoSmithKlien) Consultant on Personal Injury Suit, Morrison vs Janssen R&D 1995 Arnold and Porter representing Johnson and Johnson Expert Witness in litigation involving Advil (J&J) vs Aleve (Bayer) 1997 Horgan and Harston representing Bristol Meyers Squib 1998 Patterson Belknap

Consultant on the SMART Trial 1998 Skadden, Arps, et al. for Gillette Expertness Witness in litigation involving Gillette vs Norelco 1999 Price Waterhouse for Ortho Consultant for analysis of royalties due to Ortho for sales of Epogen vs Procrit 1999-2000 Patterson Belknap Consultant on Miscellaneous Drug Litigation 2001 Brobeck, Phleger & Harrison Consultant on legal issues 2001 Sullivan and Cromwell representing Gillette Expert Witness for Gillette in dispute with Optima 2002 Sedgwick, Detert et al representing Bayer Expert Witness for Bayer in Drug Litigation involving Aleve 2003 Patterson Belknap for Johnson & Johnson Expert Witness in Trial of Stents, Cordis vs Boston Scientific 2006 Fitzpatrick et al, Miscellaneous Consulting 2006 Pfizer, Member, Data Safety Monitoring Committee, Trial for NDA approval of Advanced Breast Cancer Therapy 2008 Phillips Lytle representing GlaxoSmithKlein Consultant on Rosiglitazone 2013 Takeda Millennium Pharmaceuticals Consultant on FDA presentation concerning NDA for IBS therapy 2017 Freshfields Bruckhaus Deringer LLP for Volkswagen Consulting on VW Diesel Emissions 2018 Intercept Pharmaceuticals Consultant on Design and Analysis of NDA drug trial for kidney fibrosis Professional Societies: Biometric Society American Statistical Association Institute for Mathematical Statistics American Association for the Advancement of Science International Clinical Biostatistics Society American Society of Genetic Epidemiology Publications: 1. Dempster AP, Laird NM, and Rubin DB. “Maximum-likelihood with incomplete data via the EM algorithm.” Journal of the Royal Statistical Society, Series B, 1977; 39:1-38. 2. Laird NM. “Nonparametric maximum-likelihood estimation of a mixing distribution.” Journal of the American Statistical Association, 1978; 73:805-811. 3. Laird NM. “Empirical Bayes methods for two-way tables.” Biometrika, 1978;

65:581-590. 4. Laird NM, Weinstein MD, Stason WB. “Issues in sample size estimation: A sensitivity analysis in the context of a clinical trial for the treatment of mild hypertension.” American Journal of Epidemiology, 1978; 109:408-419. 5. Laird NM. “Classifying Ordinal-Scale Data.” Sociological Methodology, 1979; 303-310. 6. Dempster AP, Laird NM, Rubin DB. “Iteratively reweighted least squares for linear regression when errors are normal/independent distributed.” Multivariate Analysis - V, 1980, 35-57. 7. Wilson WR, Byl FM, Laird NM. “The efficiency of steroids in the treatment of idiopathic sudden hearing loss.” Archives of Otolaryngology, 1980; 106:772-776. 8. Laird NM and Olivier DC. “Covariance analysis of survival data using log-linear analysis techniques.” Journal of the American Statistical Association, 1981; 76:231-240. Reprinted in Readings in Population Research Methodology. 9. Lowrie EG, Laird NM, Parker T, Sargent J. “The effect of hemodialysis prescription on patient morbidity: a report of the National Cooperative Dialysis Study.” New England Journal of Medicine, 1981; 305:1176-1181. 10. Wilson WR, Laird NM, Moo-Young G, Soeldner JS, Kavesh DA, MacMeel JW. “The relationship of idiopathic sudden hearing loss to diabetes mellitus.'' The Laryngoscope, 1982; 92:155-160. 11. Laird NM. “The computation of estimates of variance components using the EM algorithm.” Journal of Statistical Computation and Simulation, 1982; l4:295-303. 12. Laird NM and Louis TA. “Approximate posterior distributions for incomplete data problems.” Journal of the Royal Statistical Society, Series B, 1982; 44:190-197. 13. Laird NM and Ware JH. “Random effects models for longitudinal data: an overview of recent results.” Biometrics, 1982; 38:963-974. 14. Laird NM. “Empirical Bayes estimates using the nonparametric maximum likelihood estimate of the prior.” Journal of Statistical Computation and Simulation, 1982; 1:211-220. 15. Wilson WR, Laird NM, and Kavesh DA.“Electronystagmographic findings in patients with idiopathic sudden hearing loss.” American Journal of Otolaryngology, 1982; 3:279-285.

16. Heimendinger J and Laird NM. “Growth changes: measuring the effect of an intervention.” Evaluation Review, 1982; 7:80-95. 17. Laird NM and DerSimonian R. “Issues in combining evidence from several comparative trials of clinical therapy.'' Proceedings of the XIth International Biometrics Conference, Toulouse, France, 1982, 91-97. 1. 18. Aitkin M, Laird NM, Francis B. “A reanalysis of the Stanford Heart Transplant Data.” Journal of the American Statistical Association, 1983; 78:264-272. 19. Laird NM. “Regression to the mean, before and after treatment comparisons, and the analysis of covariance.” American Statistician, 1983; 37:329-330. 20. DerSimonian R and Laird NM. “Evaluating the effectiveness of coaching for SAT exams: a meta-analysis.” Harvard Educational Review, 1983; 53:1-15. 21. Lowrie EG, Laird NM, and Henry RH. “Protocol for the National Cooperative Dialysis Study.” Kidney International, 1983; 23: Supplement 13, S11-S18. 22. Parker TF, Laird NM, Lowrie EG. “Comparison of the study groups and a description of patient morbidity, mortality and withdrawal in the National Cooperative Dialysis Study.” Kidney International, 1983; 23:Supplement 13, S42- S49. 23. Teehan BP, Laird NM, Harter HR. “Influences of dialysis prescription on electrolyte and acid-base metabolism: The National Cooperative Dialysis Study.” Kidney International, 1983; 23:Supplement 13, S66-S72. 24. Harter HR, Laird NM, Teehan BP. “Effects of dialysis prescription on bone and mineral metabolism.'' Kidney International, 1983; 23:Supplement 13, S73-S79. 25. Schoenfeld PY, Henry RH, Laird NM, Roxe DM. “Assessment of nutritional status in the National Cooperative Dialysis Study population.” Kidney International, 1983; 23:Supplement 13, S80-S88. 26. Rao TK, Roxe DM, Laird NM, Santiago GC. “Hemodynamic and cardiac correlates of different hemodialysis regimes.” Kidney International, 1983; 23:Supplement 13, S89-S94. 27. Santiago GC, Rao TK, Laird NM. “Effect of dialysis therapy upon the hematopoietic system.” Kidney International, 1983; 23:Supplement 13, S95-S100. 28. Laird NM, Berkey CS, and Lowrie EG. “Modelling success or failure of dialysis therapy.” Kidney International, 1983; 23:Supplement 13, S101-S106. 29. Laird NM and Wilson WR. “Predicting recovery from idiopathic sudden hearing

loss.” American Journal of Otolaryngology, 1983; 4:161-164. 30. Wilson WR, Veltri RW, Laird NM, Sprinkle PM. “Viral and epidemiological studies of idiopathic sudden hearing loss.” Otolaryngology-Head and Neck Surgery, 1983; 91:653-658. 31. Heimendinger J, Laird N, Austin J, Gershoff S, Timmer P. “The effects of the WIC program on the growth of infants.” American Journal of Clinical Nutrition, 1984; 40:1250-7. 1. 32. Stern RS, Laird NM, et al. “Cutaneous squamous-cell carcinoma in patients treated with PUVA.” New England Journal of Medicine, 1984; 310:1156-1161. 33. Stiratelli R, Laird NM, Ware JH. “Random effects models for serial observations with dichotomous response.” Biometrics, 1985; 40:961-972. 34. Laird NM. “Missing information principle.” Encyclopedia of Statistical Sciences, Vol. 5 (S. Kotz and N.L. Johnson, eds.), 1985, New York: Wiley Interscience, 548- 552. 35. Maher E and Laird NM. “Reconstruction of particle size distributions from diffusion battery data using the EM algorithm.” Journal of Aerosol Sciences, 1985; 16:557-570. 36. Glynn RJ, Bouchard SM, LaCastro JS, Laird NM. “The effects of birth cohort and time on drinking behaviors in men: results from the Normative Aging Study.” American Journal of Public Health, 1985; 75:1413-1419. 37. Laird NM, Lange N, Stram D. “Maximum likelihood computations with repeated measures: Application of the EM algorithm.” 1985 Statistical Computing Section Proceedings of the American Statistical Association, 1985; 34-42. 38. Stram D, Laird NM, and Ware JH. “An algorithmic approach for the fitting of a general mixed ANOVA model appropriate in longitudinal settings.” (1986). Proceedings of the Seventeenth Symposium on the Interface of Computer Science and Statistics. 39. Berkey CS and Laird NM. “Nonlinear growth curve analyses: estimating the population parameters.” Annals of Human Biology, 1986; 13:111-128. 40. Glynn RJ, Laird NM, Rubin DB. “Selection modeling versus mixture-modeling with nonignorable nonresponse.” Drawing Inferences from Self Selected Samples (Howard Wainer, ed.), New York: Springer-Verlag, 1986, 115-142. 41. DerSimonian R and Laird NM. “Meta-Analysis in clinical trials.” Journal of Controlled Clinical Trials, 1986; 7:177-188.

42. Eavey RD, Nadol JB, Holmes LB, Laird NM, et al. “Kartagener's Syndrome: a blinded controlled study of celia ultrastructure.” Archives of Otolaryngology, 1986; 112:646-650. 43. Ozkaynak H, Ryan PB, Spengler JD, Laird NM. “Bias due to misclassification of personal exposures in epidemiologic studies of indoor and outdoor air pollution.” Environment International, 1986; 12:389-393. 44. Laird NM. “Thyroid cancer risk from exposure to internal ionizing radiation: a case study in the comparative potency model.” Risk Analysis, 1987; 7:299-307. 45. Laird NM. “Missing data in longitudinal studies.” Statistics in Medicine, 1987; 7:305-315. 46. Laird NM, Lange N, Stram D. “Maximum likelihood computations with repeated measures: Application of the EM algorithm.” Journal of the American Statistical Association, 1987; 82:97-105. 47. Laird NM and Louis TA. “Bootstrapping empirical Bayes estimates to account for sampling variation.” (with Discussion). Journal of the American Statistical Association, 1987; 82:739-757. 48. Knuiman M, Laird NM, Louis T. “An analysis of inter- and intra- laboratory variability of the Ames Test.” Mutation Research, 1987; 180:171-182. 49. Baker S and Laird NM. “Regression analysis with categorical data subject to nonignorable nonresponse.” Journal of the American Statistical Association, 1988; 83:62-69. 50. Laird NM. “Self-Consistency.'' Encyclopedia of Statistical Sciences, (S. Kotz and N.L. Johnson, eds.), New York: Wiley Interscience, 1988; 8:347-351. 51. Laird NM. “Sundberg Formulas.'' Encyclopedia of Statistical Sciences, (S. Kotz and N.L. Johnson, eds.), New York: Wiley Interscience, 1988; 9:86-91. 52. Waternaux C, Laird NM, Ware JH. “Methods for analysis of longitudinal data: Blood lead concentrations and cognitive development.” Journal of the American Statistical Association, 1989; 84:33-41. 53. Lange N and Laird NM. “Random effects and growth curve modeling for balanced and complete longitudinal data.” Journal of the American Statistical Association, 1989; 84:241-247. 54. Berlin JA, Laird NM, Sacks H, and Chalmers TC. “A comparison of statistical methods for combining event rates from clinical trials.” Statistics in Medicine, 1989; 8:141-151.

55. Berkey CS, Laird NM, Valadian I, Gardner J. “The analysis of longitudinal growth data with covariates.” Auxology '88: Perspectives in the Science of Growth and Development. (J.M.Tanner, ed.), Smith-Gordon, London, 1989; 31- 39. 56. Laird NM and Louis TA. “Empirical Bayes ranking methods.” Journal of Educational Statistics, 1989; 14:29-46. 57. Laird NM and Louis TA. “Empirical Bayes confidence intervals for a series of related experiments.” Biometrics, 1989; 45:481-495. 58. Brennan TA, Laird NM, Localio R. “Reliability and validity of judgements concerning adverse events suffered by hospitalized patients.” Medical Care, 1989; 27:1148-1158. 1. 59. Hiatt HH, Barnes BA, Brennan TA, Johnson WG, Laird NM, et al. “A study of medical injury and medical malpractice: An overview.” New England Journal of Medicine, 1989; 321:480-484. 60. Laird NM. “A conversation with F.N. David.” Statistical Science, 1989; 4:235-246. 61. Hine LK, Laird NM, Hewitt P, Chalmers TC. Meta-analytic evidence against prophylatic use of lidocaine in acute myocardial infarction.” Archives of Internal Medicine, 1989; 149:2694-2698. 62. Hine LK Laird NM, Hewitt P, Chalmers TC. “Meta-analysis of empiric chronic antiarrhythmic therapy after myocardial infarction.” Journal of the American Medical Association, 1989; 262:3037-3040. 63. Laird NM. “Analysis of linear and non-linear growth models with random parameters.” The Proceedings of the International Symposium on Advances in Statistical Methods for Genetic Improvement of Livestock, New York: Springer- Verlag, 1990; 359-374. 64. Knuiman M and Laird N. “Parameter estimation in variance component models for binary response data.'' The Proceedings of the International Symposium on Advances in Statistical Methods for Genetic Improvement of Livestock, New York: Springer-Verlag, 1990; 177-189. 65. Brennan TA, Localio RJ, Leape LL, Laird NM, Peterson L, Hiatt HH, Barnes BA. “Identification of adverse events suffered by hospitalized patients: A cross- sectional study of litigation, quality assurance and medical records at two teaching hospitals.”Annals of Internal Medicine, 1990; 112:221-226. 66. Laird NM and Mosteller F. “Some statistical methods for combining results.”

International Journal of Technology Assessment in Health Care, 1990; 6:5-30. 67. Lipsitz SR, Laird NM, and Harrington DP. “Finding the Design Matrix for the Marginal Homogeneity Model.” Biometrika, 1990; 77:353-8. 68. Surgenor DM, Keny SV, et al., and Laird NM. “Human Blood Cells at Microgravity: The NASA Initial Blood Storage Experiment.” Transfusion, 1990; 30:605-616. 69. Lipsitz SR, Laird NM, and Harrington DP. “Maximum Likelihood Regression Models for Paired Binary Data.” Statistics in Medicine, 1990; 9:1517-1525. 70. Laird NM and Wang F. “Estimating Rates of Change in Randomized Clinical Trials.” Controlled Clinical Trials, 1990; 11:404-419. 71. Lipsitz SR, Laird NM, and Harrington DP. “Using the Jackknife to Estimate the Variance of Regression Estimators from Repeated Measures Studies.” Statist Theory Meth, 1990; 19:821-45. 1. 72. Berkey CS, Valadian I, Gardner J, Laird NM. “Modelling Adolescent Blood Pressure Patterns and their Prediction of Adult Pressures.” Biometrics, 1991; 47:1005-1018. 73. Berkey CS, Laird NM, Gardner J, Valadian I. “Longitudinal Analysis of Incomplete Adolescent Data.” Annals of Human Biology, 1991; 18:311-326. 74. Laird NM and Louis TA. “Smoothing the Non-Parametric Estimate of a Prior Distribution by Roughening a Computational Study. Computational Statistics and Data Analysis, 1991; 12:27-38. 75. Laird NM. “Topics in Likelihood-Based Methods for Longitudinal Data Research.” Statistica Sinica, 1991; 1:33-50. 76. Brennan TA, Leape LL, Laird NM, et al. “Incidence of Adverse Events and Negligence in Hospitalized Patients: Results from the Harvard Medical Practice Study I.” New England Journal of Medicine, 1991; 324:370-376. 77. Leape LL, Brennan TA, Laird NM, et al. “The Nature of Adverse Events in Hospitalized Patients: Findings from the Harvard Medical Practice Study II.'' New England Journal of Medicine, 1991; 324:377-384. 78. Lipsitz SR, Laird NM, and Harrington DP. “Generalized Estimating Equations for Correlated Binary Data using the Odds Ratio as a Measure of Association.” Biometrika, 1991; 78:153-160.

79. Localio AR, Lawthers AG, Brennan TA, Laird NM, et al. “Patient Injury and Malpractice Litigation: Findings from the Harvard Medical Practice Study.” New England Journal of Medicine, 1991; 325:245-251. 80. Brennan TA, Hebert LE, Laird NM, et al. “HospitalCharacteristics Associated with Adverse Events and Substandard Care.” Journal of the American Medical Association, 1991; 265:3265-3269. 81. Leape LL, Brennan, TA, Laird N, Lawthers AG, and Hiatt H. “Adverse Events and Negligence in Hospitalized Patients.” Iatrogenics, 1991; 1:17-21. 82. Laird NM. “Estimating Rates of Change in Clinical Studies.” Chapter 12, Research Designs and Methods in Psychiatry, Vol. 9, M. Fava and J. Rosenbaum, eds., Elsevier, Amsterdam, The Netherlands, 1992; 185-194. 83. Lawthers A, Localio AR, Laird NM, Lipsitz SR, Herbert LE, Brennan TA. “Physician's perceptions of the risk of being sued.” J Health Polit Policy Law, 1992; 17:463-482. 84. Laird NM, Donnelly C, Ware JH. “Longitudinal Studies with Continuous Responses.” Statistical Methods in Medical Research, 1992; 1:3-25. 1. 85. Lipsitz SR, Laird NM, and Harrington DP. “A Three-stage Estimator for Studies with Repeated and Possibly Missing Binary Outcomes.'' Applied Statistics, 1992; 41:203-213. 86. Laird NM, Skinner J, Kenward M. “An Analysis of Two Period Cross-Over Designs with Carryover Effects.” Statistics in Medicine, 1992; 11:1967-1979. 87. Laird NM. “The EM Algorithm.” In Handbook in Statistics: Computational Statistics (C.R. Rao, ed.), Vol. 9. New York: Elsevier Science Publishers B.V., 1993, pp. 509-520. 88. Crawford SL, Johnson WG, Laird NM. “Bayes Analysis of Model-Based Methods for Nonignorable Nonresponse: Harvard Medical Practice Study.” In Case Studies in Bayesian Statistics, Gatsonis, C., Hodges, J.S., Kass, R.E. and Singpurwalla, N.D. eds. Springer-Verlag:New York, 1993. 89. Fitzmaurice GM and Laird NM. “A Likelihood-based Method for Analysing Longitudinal Binary Responses.” Biometrika, 1993; 80:141-152. 90. Glynn RJ, Laird NM, Rubin DB. “Nonignorable Nonresponse with Follow-ups: Selection and Mixture-Modelling Compared.” Journal of the American Statistical Association, 1993; 88:984-993. 91. Fitzmaurice GM, Laird NM, Rotnitzky A. “Regression Models for Discrete

Longitudinal Responses.” Statistical Science, 1993; 8:284-309. 92. Donnelly CA, Ware JH, Laird NM. “Regression Analysis of Spacially Correlated Data: The Kanawha County Health Study.” Handbook of Statistics (G.P. Patil and C.R. Rao, eds.), Vol. 12. New York: Elsevier Science B.V., 1994; pp. 643-660. 93. Fitzmaurice GM, Laird NM, Lipsitz SR. “Analysing Incomplete Longitudinal Binary Responses: A Likelihood Based Approach.” Biometrics, 1994; 50:601-613. 94. Lipsitz SR, Laird NM, Harrington DP. “Weighted Least Squares Analysis of Repeated Categorical Measurements with Outcomes Subject to Non-response.'' Biometrics, 1994; 50:11-24. 95. Lipsitz SR, Laird NM, Brennan TA. “Simple Moment Estimates of the Kappa Coefficient and Its Variance.” Applied Statistics, 1994; 43:309-323. 96. Lipsitz SR, Fitzmaurice GM, Orav EJ, Laird NM. “Performance of generalized estimating equations in practical situations.” Biometrics, 1994; 50:270-278. 97. Wang-Clow F, Laird NM, Ware JH. “A Simulation Study of Estimators for Rates of Change in Longitudinal Studies with Attrition.” Statistics in Medicine, 1995; 14:283-297. 98. Donnelly C, Laird NM, Ware JH. “Predication and Creation of Smooth Curves for Temporally Correlated Longitudinal Data.” Journal of the American Statistical Association, 1995; 90:984-989. 1. 99. Fitzmaurice GM and Laird N. “Regression Models for a Bivariate Discrete and Continuous Outcome with Clustering.” Journal of the American Statistical Association, 1995; 90:845-852. 100. Leape LL, Bates DW, Cullen DJ, Cooper J, Demonaco HJ, Gallivan T, Hallisey R, Ives J, Laird NM, et. al. “Systems Analysis of Adverse Drug Events.” Journal of the American Medical Association, 1995; 274:29-34. 101. Xu X, Laird NM, et. al. “Age, Period and Cohort Effects on Forced Expiratory Volume in One Second in Adults: A 24-Year Follow-up Study.” American Journal of Epidemiology, 1995; 6:554-566. 102. Bates DW, Cullen DJ, Laird N, Petersen LA, Small SD, Servi D, Laffel G, Sweitzer BJ, Shea BF, Hallisey R, Vander Vliet M, Nemeskal R, Leape LL. “Incidence of Adverse Drug Events and Potential Adverse Drug Events: Implications for Prevention.” Journal of the American Medical Association, 1995; 274:29-34. 103. Fitzmaurice GM, Laird NM, Zahner GEP, Daskalakis C. “Bivariate Logistic Regression Analysis of Childhood Psychopathology Ratings Using Multiple Informants.”

American Journal of Epidemiology, 1996; 142:1194-1203. 104. Fitzmaurice GM, Laird NM, Zahner GEP. “Multivariate Logistic Models for Incomplete Binary Responses.” Journal of the American Statistical Association, 1996; 91:99-108. 105. Laird NM. “Longitudinal Panel Data: An overview of current methodology.'' In: Cox DR, Hinkley DV, and Barndorff Nielsen OE. Time Series Models in Econometrics, Finance and Other Fields. London: Chapman and Hall, 1996; 143- 175. 106. Hogan JW and Laird NM. “Intention-to-Treat Analyses for Incomplete Repeated Measures Which Depend Upon Event Times.” Biometrics, 1996; 52:1002-1017. 107. Zackin R, De Gruttola V, Laird NM. “Mixed Effects Models for Estimating the Effect of Antiviral Therapy on the Burden of the Human Immunodeficiency Virus.'” Journal of the American Statistical Association, 1996; 91:52-61. 108. Hogan JW and Laird NM. “Mixture Models for the Joint Distribution of Repeated Measures and Event Times.” Statistics in Medicine, 1997; 16:239-257. 109. Hogan JW and Laird NM. “Model-Based Approaches to Analyzing Incomplete Longitudinal and Failure Time Data.” Statistics in Medicine, 1997, 16:259-272. 110. Cnaan A, Laird NM, Slasor P. “Using the General Linear Mixed Model to Analyze Unbalanced Repeated Measures and Longitudinal Data.” Statistics in Medicine, 1997; 16:2349-2380. 111. Fitzmaurice GM and Laird N. “Regression Models for Mixed Discrete and Continuous Responses with Potentially Missing Values: A Likelihood Based Approach.” Biometrics, 1997; 53:110-122. 1. 112. Shah A, Laird N, Schoenfeld D. “A Random Effects Model for Multiple Characteristics with Possibly Missing Data.” Journal of the American Statistical Society, 1997; 92:775-779. 113. Bates DW, Spell N, Cullen DJ, Burdick E, Laird NM, Petersen LA, Small SD, Sweitzer, BJ, Leape LL. “The Costs of Adverse Drug Events in Hospitalized Patients.” Journal of the American Medical Association, 1997; 277:307-311. 114. Van Eerdewegh P, Santangelo SL, Blacker D, Lee H, Laird NM.“Probabilistic Diagnosis in Linkage Analysis of Bipolar Disorder: Putting Weights on the Fringe.” Genetic Epidemiology, 1997; 14:693-698. 115. Murphy JM, Monson RR, Laird NM, Sobol AM, Leighton AH.“Identifying depression and anxiety in a 40-year epidemiological investigation: the Stirling County

study.” International Journal of Methods in Psychiatric Research, 1998; 7:89-109. 116. Hogan JW and Laird NM. “Increasing Efficiency from Censored Survival Data Using Random Effects to Model Longitudinal Covariates.” Statistical Methods in Medical Research, 1998; 7:28-48. 117. Kleinman KP, Ibrahim JG, Laird NM. “A Bayesian Framework for Intent-to-treat Analysis with Missing Data.” Biometrics, 1998; 54:265-278. 118. Lipsitz SL, Dear KBG, Laird NM, Molenberghs G. “Tests of Homogeneity of the Risk Difference When Data are Sparce.” Biometrics, 1998; 54:148-160. 119. Horvath S and Laird N. “Discordant Sibship Test for Disequilibrium/Transmission: No Need for Parental Data.” American Journal of Human Genetics, 1998; 63:1886- 1897. 120. Laird NM. “The EM Algorithm.” Encyclopedia of Biostatistics, 1998; 2:1300-1313. 121. Bates DW, Leape L, Cullen DJ, Laird N, Petersen LA, Teich JM, Burdick E, Hickey M, Kleefield S, Shea B, Vander Vliet M, Seger D. “Effect of computerized physician order entry and a team intervention on prevention of serious medication errors.” Journal of the American Medical Association, 1998; 280(15):1311-1316. 122. Horton NJ and Laird NM. “Maximum Likelihood Analysis of Generalized Linear Models with Missing Covariates.” Statistical Methods in Medical Research, 1998; 8:37-50. 123. Korhonen P, Laird N, Palmgren J. “Correcting for Noncompliance in Randomized Trials: An Application to the ATBC Study.” Statistics in Medicine, 1999; 18:2879- 2897. 124. Niu T, Yang J, Wang B, Chen W, Wang Z, Laird N et al. “Angiotensinogen Gene Variants T235/M174: No Excess Transmission to Hypertensive Chinese.” Hypertension, 1999; 33(2):698-702. 1. 125. Gortmaker SL, Peterson K, Wiecha J, Sobol AM, Dixit S, Fox MK, Laird N. “Reducing Obesity via a School-Based Interdisciplinary Intervention Among Youth.” Archives of Pediatrics and Adolescent Medicine, 1999; 153:409-418. 126. Gortmaker SL, Cheung LWY, Peterson KE, Chomitz G, Cradle JH, Dart H, Fox MK, Bullock, RB, Sobol A, Colditz G, Field A, Laird N. “Impact of a School- Based Interdisciplinary Intervention on Diet and Physical Activity Among Urban Primary School Children: Eat Well and Keep Moving.” Archives of Pediatrics and Adolescent Medicine, 1999; 153:975-983. 127. Hernandez B, Gortmaker SL, Colditz GA, Peterson KE, Laird NM, Parra-Cabrera

S. “Association of obesity with physical activity, television programs and other forms of video viewing among children in Mexico City.” International Journal of Obesity, 1999; 23:845-854. 128. Bates DW, Miller EB, Cullen DJ, Burdick L, Williams L, Laird N, Petersen LA, Small SD, Sweitzer BJ, Vliet MV, Leape LL for the ADE Prevention Study Group. “Patient Risk Factors for Adverse Drug Events in Hospitalized Patients.” Archives of Internal Medicine, 1999; 159:2553-2560. 129. Horton NJ, Laird NM, Zahner GEP. “Use of Multiple Informant Data as a Predictor in Psychiatric Epidemiology.” International Journal of Methods in Psychiatric Research, 1999; 8:6-18. 130. Field AE, Byers T, Hunter DF, Laird NM, Manson JE, Williamson DF, Willett WC, and Colditz GA. “Weight Cycling, Weight Gain.” American Journal of Epidemiology, 1999; 105:573-579. 131. Hernandez B, Gortmaker SL, Laird NM, Colditz GA, Parra-Cabrera S, Peterson KE. “Validity and Reproducibility of a Questionnaire on Physical Activity and Non-activity for School Children in Mexico City.” Salud Publica Mex, 2000; 42:315-323. 132. Murphy JM, Monson RR, Laird NM, Sobol AM, Leighton AH. “A comparison of diagnostic interviews for depression in the Stirling County Study: challenges for psychiatric epidemiology.” Archives of General Psychiatry, 2000; 57:230-236. 133. Murphy JM, Laird NM, Monson RR, Sobol AM, Leighton AH. “A Forty-Year Perspective on the Prevalence of Depression from The Stirling County Study.”Archives of General Psychiatry, 2000; 57:209-215. 134. Pauler DK and Laird NM. “A Mixture Model for Longitudinal Data with Application to Assessment of Noncompliance.” Biometrics, 2000; 56:464-472. 135. Lunetta KL, Faraone SV, Biederman J, Laird NM. “Family-Based Tests of Association and Linkage That Use Unaffected Sibs, Covariates, and Interactions.” American Journal of Human Genetics, 2000; 66:605-614. 1. 136. Rabinowitz D and Laird N. “A unified Approach to Adjusting Association Tests for Population Admixture with Arbitrary Pedigree Structure and Arbitrary Missing Marker Information.” Human Heredity, 2000; 504:227-233. 137. Horvath S, Laird NM, Knapp M. “The transmission/disequilibrium test and parental genotype reconstruction for X-chromosomal markers.” American Journal of Human Genetics, 2000; 66:1161-1167. 138. Laird NM, Horvath S, Xu X. “Implementing a Unified Approach to Family Based

Tests of Association.” Genetic Epidemiology, 2000; 19(Suppl 1):S36-S42. 139. Fitzmaurice GM and Laird NM. “Generalized linear mixture models for handling nonignorable dropouts in longitudinal studies.” Biostatistics, 2000; 1:141-156. 140. Murphy JM, Monson RR, Laird NM, Sobol AM, Leighton AH. “Studying the incidence of depression: an `interval' effect.” International Journal of Methods in Psychiatric Research, 2000; 9(4):184-193. 141. Lake S, Blacker D, Laird NM. “Family-Based Tests of Association in the Presence of Linkage.” American Journal of Human Genetics, 2000; 67:1515-1525. 142. Laird NM, Fitzmaurice GM, Schwartz AG. “The Analysis of Case-Control Data: Epidemiologic Studies of Familial Aggregation.” Handbook of Environmental and Public Health Statistics, 2000; 18:465-482. 143. Murphy JM, Laird NM, Monson RR, Sobol AM, Leighton AH. “Incidence of Depression in the Stirling County Study: Historical and Comparative Perspectives.” Psychological Medicine, 2000; 30:505-514. 144. Horvath S, Xu X, Laird NM. “The Family-Based Association Test Method: Strategies for Studying General Phenotype-Genotype Associations.” European Journal of Human Genetics, 2001; 9:301-306. 145. Hudson JI, Laird, NM, Betensky RA. “Multivariate Logistic Regression for Familial Aggregation of Two Disorders: I. Development of Models and Methods.” American Journal of Epidemiology, 2001; 153:500-505. 146. Hudson JI, Laird, NM, Betensky RA, Keck PE, Jr, Pope HG, Jr. “Multivariate Logistic Regression for Familial Aggregation of Two Disorders: II. Analysis of Studies of Eating and Mood Disorders.” American Journal of Epidemiology, 2001; 153:506-514. 147. Smoller JW, Rosenbaum JF, Biederman J, Susswein LS, Kennedy J, Kagan J, Snidman N, Laird N, Tsuang MT, Faraone SV, Schwarz A, Slaugenhaupt SA. “Genetic Association Analysis of Behavioral Inhibition Using Candidate Loci From Mouse Models.” American Journal of Medical Genetics Neuropsychiatric Genetics), 2001; 105:226-235. 1. 148. Horton NJ and Laird NM. “Maximum Likelihood Analysis of Logistic Regression Models with Incomplete Covariate Data and Auxillary Information.” Biometrics, 2001; 57:34-42. 149. Field AE, Coakley E, Dietz W, Must A, Spadano J, Laird NM, Rimm E, Colditz E. “Impact of Overweight on the Risk of Developing Common Chronic Diseases Over a 10-Year Period.” Archives of Internal Medicine, 2001; 161:1581-1586.

150. Horton NJ, Laird NM, Murphy JM, Monson RR, Sobol AM, Leighton AH. “Multiple Informants: Motality Associated with Psychiatric Disorders in the Stirling County Study.” American Journal of Epidemiology, 2001; 154:1-8. 151. Fitzmaurice GM, Laird NM, Shneyer L. “An alternative parameterization of the general linear mixture model for longitudinal data with non-ignorable dropouts.” Statistics in Medicine, 2001; 20:1009-1021. 152. Fitzmaurice GM and Laird NM. “Logistic regression.” In: International Encyclopedia of the Social and Behavioral Sciences (N. Smelser and P. Baltes, eds.). New York: Elsevier, 2001. 153. Naumova EN, Must A, Laird NM. “Evaluating the impact of `critical periods' in longitudinal studies of growth using piecewise mixed effects models.” International Journal of Epidemiology, 2001; 30:1332-1341. 154. Lake S, Blacker, Laird N. “Family based tests in the presence of association.” Amer J Hum Gen, 2001; 67:1515-1525. 155. Pauler DK and Laird NM. “Nonlinear Hierarchical Models for Monitoring Compliance.” Statistics in Medicine, 2002; 21:219-229. 156. Daskalakis C, Laird NM, Murphy JM. “Regression Analysis of Multiple-Source Longitudinal Outcomes: A 'Stirling County' Depression Study.” American Journal of Epidemiology, 2002; 155:88-94. 157. Smoller JW, Rosenbaum JF, Biederman J, Kennedy J, Dai D, Racette S, Laird N, et al.“Association of a genetic marker at the corticotropin releasing hormone locus with behavioral inhibition.” Am J Med Genet, 2002; 114:090. 158. Murphy JM, Nierenberg AA, Monson RR, Laird NM, Sobol AM, Leighton “A.Self- Disparagement as Feature and Forerunner of Depression: Findings from the Stirling County Study.” Compr Psychiatry, 2002; 43:13-21. 159. Lange C, DeMeo DL, Laird NM. “Power and design considerations for a general class of family-based association tests: quantitative traits.” Am J Hum Genet, 2002; 71:1330-1341. 160. Lange C and Laird NM. “On a general class of conditional tests for family-based association studies in genetics: the asymptotic distribution, the conditional power, and optimality considerations.” Genet Epidemiol, 2002; 23:165-180. 1. 161. Lange C and Laird NM. “Power calculations for a general class of family-based association tests: dichotomous traits.” Am J Hum Genet, 2002; 71:575-584.

162. Horvath S and Laird NM. “Family based association for quantitative traits.” Biostatistical Genetics & Genetic Epidemiolog, Wiley, IBSN, 2002; 232-245. 163. Laird NM. “EM algorithm.” Biostatistical Genetics & Genetic Epidemiology, Wiley, IBSN, 2002; 264-267. 164. Murphy JM, Nierenberg AA, Laird NM, Monson RR, Sobol AM, Leighton AH. “Incidence of major depression: prediction from subthreshold categories in the Stirling County Study.” J Affect Disord, 2002; 68:251-259. 165. DeMeo DM, Lange C, Silverman EK, Senter JM, Drazen JM, Barth MJ, Laird NM, Weiss ST. “Univariate and multivariate family based analysis of the ARG130GLN polymorphism of the ill3 gene in the childhood asthma management program.” Genetic Epi, 2002; 23:335-348. 166. Lange C, DeMeo D, Laird NM. “Power calculations for a general class of family- based association tests: Quantitative traits.” Am J Hum Genet, 2002; 71:575-584. 167. Horton NJ, Saitz R, Laird NM, Samet JH. “A method for modeling utilization data from multiple sources: application in a study of linkage to primary care.” J Health Services & Outcomes Research Methodology, 2002; 3:211-223. 168. Lange C, Silverman EK, Xu X, Weiss ST, Laird NM. “A multivariate family-based association test using generalized estimating equations: FBAT-GEE.” Biostatistics, 2003; 4:195-206. 169. Laird NM and Cuenco KT. “Regression methods for assessing familial aggregation of disease.” Stat Med, 2003; 22:1447-1455. 170. Hudson JI, Mangweth B, Pope HG Jr, De Col C, Hausmann A, Gutweniger S, Laird NM, Biebl W, Tsuang MT. “Family study of affective spectrum disorder.'' Arch Gen Psychiatry, 2003; 60:170-177. 171. Slasor P and Laird N. “Joint models for efficient estimation in proportional hazards regression models.” Stat Med, 2003; 22:2137-2148. 172. Murphy JM, Horton NJ, Monson RR, Laird NM, Sobol AM, Leighton AH. “Cigarette smoking in relation to depression: Historical trends from the Stirling County Study.” Am J Psych, 2003; 160:1663-1660. 173. Mangweth B, Hudson JI, Pope HG, Hausmann A, De Col C, Laird NM, Beibl W, Tsuang MT. “Family study of the aggregation of eating disorders and mood disorders.” Psychological Medicine, 2003; 33:1319-1323.

174. Lange C, DeMeo D, Silverman E, Weiss S, Laird NM. “Using the noninformative families in family-based association tests: a powerful new testing strategy.” Am J Hum Genet, 2003; 73:801-811. 1. 175. Lake SL, Lyon H, Tantisira K, Silverman EK, Weiss ST, Laird NM, Schaid DJ. “Estimation and tests of haplotype-environment interaction when linkage phase is ambiguous.” Human Heredity, 2003; 55:56-65. 176. Yang Q, Xu X, Laird NM. “Power evaluation for family-based tests of association with incomplete parental genotypes.” Genetics, 2003; 164:399-406. 177. Saunders AJ, Betram L, Mullin K, Sampson AJ, Latifzai K, Basu S, Jones J, Kinney D, MacKenzie-Ingano L, Yu S, Albert MS, Moscarillo TJ, Go RC, Bassett SS, Daly MJ, Laird NM,Wang X, Velicelebi G, Wagner SL, Becker DK, Tanzi RE, Blacker D. “Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroblobulin.” Hum Mol Genet, 2003; 12:2765-76. 178. Silverman EK, Kwiatkowski DJ, Sylvia JS, Lazarus R, Drazen JM, Lange C, Laird NM, Weiss ST. “Family-based association analysis of beta(2)-adrenergic receptor polymorphisms in the childhood asthma management program.” J Allergy Clin Immunol, 2003; 112:870-876. 179. Smoller JW, Rosenbaum JF, Biederman J, Kennedy J, Dai D, Racette SR, Laird NM, Kagan J, Snidman N, Hirshfeld-Becker D, Tsuang MT, Sklar PB, Slaugenhaupt SA. “Association of a genetic marker at the corticotropin-releasing hormone locus with behavioral inhibition.” Biol Psychiatry, 2003; 54:1376-1381. 180. Lange C, Blacker D, Laird NM. “Family-based association tests for survival and time-to-onset analysis.” Statist Med, 2003; 22:179-189. 181. Field AE, Laird N, Steinberg E, Fallon E, Semega-Janneh M, Yanovski JA. “Which metric of relative weight best captures body fatness in children?” Obes Res, 2003; 11(11):1345-52. 182. Hao K, Xu X, Laird N, Wang X, Xu X. “Power estimation of multiple SNP association test of case-control study and application.” Genet Epidemiol, 2004; 26(1):22-30. 183. Lake S and Laird N. “Tests of gene-environment interaction for case-parent triads with general environmental exposures.'' Ann Hum Genet, 2004; 68:55-64. 184. Horvath S, Xu X, Lake SL, Silverman EK, Weiss ST, Laird NM. “Family based tests for associating haplotypes with general phenotype data: Application to asthma genetics.” Genet Epidemiol, 2004; 26:61-69. 185. Lange C, DeMeo D, Silverman E, Weiss S, Laird NM. “PBAT: tools for family-

based association studies.” Am J Hum Genet, 2004; 74:367-369. 186. Lyon H, Lange C, Silverman EK, Senter JM, Drazen JM, Barth MJ, Laird N, Weiss ST. “Univariate and multivariate family based analysis of the ill0 gene in the childhood asthma management program.” Genetic Epi, 2004; 26:155-165. 1. 187. Field AE, Manson JE, Laird N, Williamson DF, Willett WC, Colditz GA. “Weight cycling and the risk of developing Type 2 Diabetes among adult women in the United States.” Obes Res, 2004; 12:267-274. 188. Hao K, Wang X, Niu T, Xu X, Li A, Chang W, Wang L, Li G, Laird N, Xu X. “A candidate gene association study on preterm delivery: application of high- throughput genotyping technology and advanced statistical methods.” Hum Mol Genet, 2004; 13(7): 683-91. 189. Murphy JM, Horton NJ, Laird NM, Monson RR, Sobol AM, Leighton AH. “Anxiety and depression: a 40-year perspective on relationships regarding prevalence, distribution and comorbidity.” Acta Psychiatr Scand, 2004; 109(5):355- 75. 190. Feng Y, Niu T, Xing H, Xu X, Chen C, Peng S, Wang L, Laird N, Xu X. “A common haplotype of the nicotine acetylcholine receptor alpha 4 subunit gene is associated with vulnerability to nicotine addiction in men.” Am J Hum Genet, 2004; 75(1):112-21. 191. Celedon JC, Lange C, Raby BA, Litonjua AA, Palmer LJ, DeMeo DL, Reilly JJ, Kwaitowski DJ, Chapman HA, Laird N, Sylvia JS, Hernandez M, Speizer FE, Weiss ST, Silverman EK. “The transforming growth factor-$\beta$ 1 (TGFB1) gene is associated withchronic obstructive pulmonary disease (COPD).” Hum Mol Genet, 2004; 13(15):1649-1656. 192. Slasor P and Laird N. “Categorical auxiliary data in the discrete time proportional hazards model.” Handbook of Statistics: Survival Analysis, 2004; 23:363-382. 193. Smoller JW, Yamaki LH, Fagerness JA, Biederman J, Racette S, Laird NM, Kagan J, Snidman N, Faraone SV, Hirschfeld-Becker D, Tsuang MT, Slaugenhaupt SA, Rosenbaum JF, Sklar PB.“ The corticotrophin-releasing hormone gene and behavioral inhibition in children at risk for panic disorder.” Biol Psychiatry, 2005; 57:1485-92. 194. Van Steen K, McQueen MB, Herbert A, Raby B, Lyon H, Demeo DK, Murphy A, Su J, Datta S, Rosenow C, Christman M, Silverman EK, Laird NM, Weiss ST, Lange C. “Genomic screening and replication using the data set in family-based association testing.” Nat Genet, 2005; 37:683-91. 195. Hsu YH, Venners SA, Terwedow HA, Feng Y, Niu TH, Li ZP, Laird N, Brain JD, Cummings SR, Bouxsein ML, Rosen CJ, Xu XP. “Relation of body composition, fat

mass, and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and women.” Am J Clin Nutr, 2006; 83(1):146-154. 196. Hsu YH, Niu TH, Terwedow HA, Xu X, Feng Y, Li ZP, Brain JD, Rosen CJ, Laird N, Xu XP. “Variation in genes involved in the RANK/RANK/OPG bone remodeling pathway are associated with bone mineral density at different skeletal sites in men.” Hum Genet, 2006; 118(5):568-577. 1. 197. Wang L, Wang XB, Laird N, Zuckerman B, Stubblefield P, Xu X. “Polymorphism in maternal LRP8 gene is associated with fetal growth.'' Am J Hum Genet, 2006; 78(5):770-777. 198. Hersh CP, DeMeo DL, Lange C, Litonjua AA, Reilly JJ, Kwiatkowski D, Laird N, Sylvia JS, Sparrow D, Speizer FE, Weiss ST, Silverman EK. “Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations.” Am J Respir Cell & Mol Biol, 2005; 33(1):71-78. 199. Lasky-Su J, Lange C, Laird N, Tsuang M, Faraone S, Sklar P. “A study of how socioeconomic status moderates the relationship between SNPS encompassing BDNF and ADHD symptom counts in ADHD families.” Am J Med Genet, Part B, 2005; 38B(1):57-58. 200. Lasky-Su JA, Lange C, Laird N, Tsuang MT, Faraone SV, Sklar P. “Family based association analysis of a statistically derived quantitative trait for ADHD reveals an association in DRD4 with inattentive symptoms in ADHD individuals.” Am J Med Genet, Part B., 2005; 138B(1):9-9. 201. Schneiter K, Laird N, Corcoran C. “Exact family-based association tests for biallelic data.” Genet Epidem, 2005; 29(3):185-194. 202. Field AE, Austin SB, Striegel-Moore R, Taylor CB, Camargo CA, Laird N, Colditz G. “Weight concerns and weight control behaviors of adolescents and their mothers.” Arch Pediat & Adoles Med, 2005; 159(12):1121-1126. 203. McQueen MB, Devlin B, Faraone ST, Nimgaonkar VL, Sklar P, Smoller JW, Jamra RA, Albus M, Bacanu SA, Baron M, Barrett TB, Berrettini W, Blacker D, William W, Cichon S, Coryell W, Craddock N, Daley WR, DePaulo M, Edenberg HJ, Foroud T, Gill M, Gilliam TC, Hamshere M, Jones I, Jones L, Juo S-H, Kelsoe JR, Lambert D, Lange C, Lerer B, Liu J, Wolfgang W, MacKinnon JD, McInnis MG, McMahon FJ, Murphy DL, Noten MM, Nurnberger JI, Pato CN, Pato MT, Potash JB, Propping P, Pulver AE, Rice JP, Rietschel M, Scheftner W, Schumacher J, Segurado R, Van Steen K, Xie P, Zandi W, Laird NM. “Combined analysis from eleven linkage studies of biopolar disorder provides strong evidence for susceptibility loci on chromosomes 6q and 8q.” Amer Jour Human Genet.2005; 77(4): 1485-92.

204. Laird NM, Kraft P, Lange C, Van Steen K. “Testing for association in genetic studies.” 2006; In Respiratory Genetics, E.K. Silverman, et al., Editors. 2005, Hodder Arnold: London. p. 27-46. 205. Herbert A, Gerry NP, McQueen MB, Heid IM, Pfeufer A, Illig T, Wichmann HE, Meitinger T, Hunter D, Hu FB, Colditz G, Hinney A, Hebebrand J, Koberwitz K, Zhu X, Cooper R, Ardlie K, Lyon H, Hirschhorn JN, Laird NM, et al. “A common genetic variant is associated with adult and childhood obesity.” Science, 2006; 312(5771): 279-83. 205. 206. Hsu YH, Niu T, Terwedow HA, Xu X, Feng Y, Li Z, Brain JD, Rosen CJ, Laird N, Xu X. “Variation in genes involved in the RANKL/RANK/OPG bone remodeling pathway are associated with bone mineral density at different skeletal sites in men.” Hum Genet, 2006; 118(5): 568-77. 207. Hsu YH, Venners SA, Terwedow HA, Feng Y, Niu T, Li Z, Laird N, et al. “Relation of body composition, fat mass, and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and women.” Am J Clin Nutr, 2006; 83(1): 146-54. 208. McQueen MB, Blacker D. Laird NM. “Variance calculations for identity- by- descent estimation.” Am J Hum Genet, 2006; 78(6): 914-21. 209. Hudson JI, Lalonde JK, Berry JM, Pindyck LJ, Bulik CM, Crow SJ, McElroy SL, Laird NM, et al. “Binge-eating disorder as a distinct familial phenotype in obese individuals.” Arch Gen Psychiatry, 2006; 63(3): 313-9. 210. Laird NM and Lange C. “Family-based designs in the age of large-scale gene- association studies.” Nat Rev Genet, 2006; 7(5): 385-94. 211. Wang L, Wang X, Laird N, Zuckerman B, Stubblefield P, Xu X. “Polymorphism in maternal LRP8 gene is associated with fetal growth.” Am J Hum Genet, 2006; 78(5): 770-7. 212. Xu X, Rakovski C, Xu X, Laird N. “An efficient family-based association test using multiple markers.” Genet Epidemiol, 2006; 30(7): 620-6. 213. Litman HJ, Horton NJ, Murphy JM, Laird NM. “Marginal regression models with a time to event outcome and discrete multiple source predictors.” Lifetime Data Anal, 2006; 12(3): 249-65. 214. Rakovski CS, Xu X, Lazarus R, Blacker D, Laird NM. “A new multimarker test for family-based association studies.” Genet Epidemiol, 2007; 31(1):9-17. 215. Lyon HN, Emilsson V, Hinney A, Heid IM, Lasky-Su J, Zhu X, Thorleifsson G, Gunnarsdottir S, Walters GB, Thorsteinsdottir U, Kong A, Gulcher J, Nguyen TT, Scherag A, Pfeufer A, Meitinger T, Bronner G, Rief W, Soto-Quiros ME, Avila L,

Klanderman B, Raby BA, Silverman EK, Weiss ST, Laird N, et al. “The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts.” PLoS Genet, 2007; 3(4): e61. 216. Litman HJ, Horton NJ, Hernandez B, Laird NM. “Incorporating missingness for estimation of marginal regression models with multiple source predictors.” Stat Med, 2007; 26(5): 1055-68. 217. Harezlak J, Naumova E, Laird NM. “LongCriSP: a test for bump hunting in longitudinal data.” Stat Med, 2007; 26(6): 1383-1397. 205. 218. Harezlak J, Coull BA, Laird NM, Magari SR and Christiani DC. Penalized solutions to functional regression problems. Comput Stat Data Anal, 2007; 51(10): 4911-4925. PMCID: PMC2084351 219. Mansour HA, Chowdari KV, Wood J, Pless L, McClendon TB, King AJ, Allen M, Bowden CL, Calabrese J, El-Mallakh RS, Fagiolini A, Faraone SV, Fossey MD, Friedman ES, Gyulai L, Hauser P, Ketter TA, Laird N, Loftis JM, Marangell LB, Miklowitz DJ, McQueen MB, Nierenberg AA, Patel J, Sachs GS, Sklar P, Smoller JW, Thase ME, Frank E, Kupfer DJ, Devlin B and Nimgaonkar VL. Circadian gene polymorphisms and liability to bipolar I disorder. Bipolar Disorders, 2007; 9: 73- 74. 220. McQueen MB, Weiss S, Laird NM, Lange C. “On the parsing of statistical information in family-based association testing.” Nature Genetics, 2007; 39(3): 281-282. 221. Van Steen K, Laird NM, Markel P, Molenberghs G. “Approaches to handling incomplete data in family-based association testing.” Annals of Human Genetics, 2007; 71:141-151. 222. Lasky-Su J, Biederman J, Laird N, Tsuang M, Doyle AE, Smoller JW, Lange C, Faraone SV. “Evidence for an Association of the Dopamine D5 Receptor Gene on Age at Onset of Attention Deficit Hyperactivity Disorder.” Ann Hum Genet, 2007; 71: 648-659. 223. Lasky-Su J, Faraone SV, Lange C, Tsuang MT, Doyle AE, Smoller JW, Laird NM, Biederman J. “A Study of how Socioeconomic Status Moderates the Relationship between SNPs Encompassing BDNF and ADHD Symptom Counts in ADHD Families.” Behav Genet, 2007; 37(3):487-497. 224. Rakovski CS, Xu X, Lazarus R, Blacker D, Laird NM. A new multimarker test for family-based association studies. Genet Epidemiol, 2007; 31(1):9-17. 225. Ionita-Laza I, McQueen MB, Laird NM, Lange C. “Genomewide weighted hypothesis testing in family-based association studies, with an application to a 100K scan.” Am J Hum Genet, 2007; 81(3):607-14.

226. Bertram L, Lange C, Mullin K, Parkinson M, Hsiao M, Hogan MF, Schjeide BM, Hooli B, Divito J, Ionita I, Jiang H, Laird N, Moscarillo T, Ohlsen KL, Elliott K, Wang X, Hu-Lince D, Ryder M, Murphy A, Wagner SL, Blacker D, Becker KD and Tanzi RE. Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE. Am J Hum Genet, 2008; 83(5): 623- 32. PMCID: PMC2668052 227. Field AE, Javaras KM, Aneja P, Kitos N, Camargo CA, Jr., Taylor CB and Laird NM. Family, peer, and media predictors of becoming eating disordered. Arch Pediatr Adolesc Med, 2008; 162(6): 574-9. 205. 228. Hudson JI, Javaras KN, Laird NM, VanderWeele TJ, Pope HG, Jr. and Hernan MA. A structural approach to the familial coaggregation of disorders. Epidemiology, 2008; 19(3): 431-9. 229. Javaras KN, Laird NM, Born-Kjennerud TR, Bulik CM, Pope HG and Hudson JI. Familiality and heritability of binge eating disorder: Results of a case-control family study and a twin study. Int J Eat Disorders, 2008; 41(2): 174-179. 230. Lasky-Su J, Anney RJ, Neale BM, Franke B, Zhou K, Maller JB, Vasquez AA, Chen W, Asherson P, Buitelaar J, Banaschewski T, Ebstein R, Gill M, Miranda A, Mulas F, Oades RD, Roeyers H, Rothenberger A, Sergeant J, Sonuga-Barke E, Steinhausen HC, Taylor E, Daly M, Laird N, Lange C and Faraone SV. Genome- wide association scan of the time to onset of attention deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet, 2008; 147B(8): 1355-8. PMCID: PMC2605611 231. Ionita-Laza I, Laird NM, Raby BA, Weiss ST and Lange C. On the frequency of copy number variants. Bioinformatics, 2008; 24(20): 2350-5. 232. Ionita-Laza I, Perry GH, Raby BA, Klanderman B, Lee C, Laird NM, Weiss ST and Lange C. On the analysis of copy-number variations in genome-wide association studies: a translation of the family-based association test. Genet Epidemiol, 2008; 32(3): 273-84. 233. Javaras KN, Pope HG, Lalonde JK, Roberts JL, Nillni YI, Laird NM, Bulik CM, Crow SJ, McElroy SL, Walsh BT, Tsuang MT, Rosenthal NR and Hudson JI. Co- occurrence of binge eating disorder with psychiatric and medical disorders. J Clin Psychiatry, 2008; 69(2): 266-73. 234. Laird NM and Lange C. Family-based methods for linkage and association analysis. Adv Genet, 2008; 60: 219-52. 235. Lasky-Su J, Lyon HN, Emilsson V, Heid IM, Molony C, Raby BA, Lazarus R, Klanderman B, Soto-Quiros ME, Avila L, Silverman EK, Thorleifsson G, Thorsteinsdottir U, Kronenberg F, Vollmert C, Illig T, Fox CS, Levy D, Laird N, Ding X, McQueen MB,

Butler J, Ardlie K, Papoutsakis C, Dedoussis G, O'Donnell CJ, Wichmann HE, Celedon JC, Schadt E, Hirschhorn J, Weiss ST, Stefansson K and Lange C. On the replication of genetic associations: timing can be everything! Am J Hum Genet, 2008; 82(4): 849-58. 236. Lasky-Su J, Neale BM, Franke B, Anney RJ, Zhou K, Maller JB, Vasquez AA, Chen W, Asherson P, Buitelaar J, Banaschewski T, Ebstein R, Gill M, Miranda A, Mulas F, Oades RD, Roeyers H, Rothenberger A, Sergeant J, Sonuga-Barke E, Steinhausen HC, Taylor E, Daly M, Laird N, Lange C and Faraone SV. Genome- wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. Am J Med Genet B Neuropsychiatr Genet, 2008; 147B(8): 1345-54. 205. 237. Lasky-Su J, Lange C, Biederman J, Tsuang M, Doyle AE, Smoller JW, Laird N, Faraone S. Family-based association analysis of a statistically derived quantitative traits for ADHD reveal an association in DRD4 with inattentive symptoms in ADHD individuals. Am J Med Genet B Neuropsychiatr Genet, 2008 Jan 5;147(1):100-6. 238. Murphy JM, Burke JD, Jr., Monson RR, Horton NJ, Laird NM, Lesage A, Sobol AM and Leighton AH. Mortality associated with depression: a forty-year perspective from the Stirling County Study. Soc Psychiatry Psychiatr Epidemiol, 2008; 43(8): 594-601. 239. Neale BM, Lasky-Su J, Anney R, Franke B, Zhou K, Maller JB, Vasquez AA, Asherson P, Chen W, Banaschewski T, Buitelaar J, Ebstein R, Gill M, Miranda A, Oades RD, Roeyers H, Rothenberger A, Sergeant J, Steinhausen HC, Sonuga-Barke E, Mulas F, Taylor E, Laird N, Lange C, Daly M and Faraone SV. Genome-wide association scan of attention deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet, 2008; 147B(8): 1337-44. PMCID: PMC2831205 240. Rakovski CS, Weiss ST, Laird NM and Lange C. FBAT-SNP-PC: an approach for multiple markers and single trait in family-based association tests. Hum Hered, 2008; 66(2): 122-6. 241. Javaras KN, Laird NM, Born-Kjennerud TR, Bulick CM, Pope HG, Hudson JI. Familiality and heritability of binge eating disorder: Results of a case-control family study and a twin study. Int J Eating Disorders, 2008; 41(2):174-179. 242. Javaras KN, Pope HG, Lalonde JK, Roberts JL, Nillni YI, Laird NM, Crow SJ, McElroy SL, Walsh BT, Tsuang MT, Rosenthal NR, Hudson JI. Co-occurrence of binge eating disorder with psychiatric and medical disorders. J Clin Psychiatry, 2008; 69(2):266-273. 243. Ionita-Laza I, MCQueen MB, Weiss S, Laird NM, Lange C. Optimal two-stage testing for family-based genome-wide association studies – Response to MacGregor. Am J Hum Genet, 2008; 82(3):799-800.

244. Ionita-Laza I, Perry GH, Raby BA, Klanderman B, Lee C, Laird NM, Weiss ST, Lange C. On the analysis of copy-number variations in genome-wide association studies: A translation of the family-based association test. Genet Epidem, 2008; 32(3):273-384. 245. Hudson JI, Javaras KN, Laird NM, Vander Weele TJ, Pope HG, Heranan MA. A structural approach to the familial coaggregation of disorders. Epidem, 2008; 19(3): 431-439. 246. Ionita-Laza I, Laird NM, Raby BA, Weiss ST, Lange C. On the frequency of copy number variants. Bioinform, 2008; 24(20):2350-2355. PMCID: PMC2562008 247. Rakovski CS, Weiss ST, Laird NM, Lange C. FBAT-SNP-PC: An approach for multiple markers and single trait in family-based association tests. Hum Hered, 2008; 66(2):122-6. 205. 248. Ding X and Laird N. Family-Based Association Tests with longitudinal measurements: handling missing data. Hum Hered, 2009; 68(2): 98-105. PMCID: PMC2874738 249. Ding X, Lange C, Xu X, Laird N. New powerful approaches for family-based association tests with longitudinal measurements. Ann Hum Genet, 2009; 73(1): 74- 83. 250. Ding X, Weiss S, Raby B, Lange C and Laird NM. Impact of population stratification on family-based association tests with longitudinal measurements. Stat Appl Genet Mol Biol, 2009; 8(1): Article 17. PMCID: PMC2861319 251. Hoffmann TJ and Laird NM. fgui: A Method for Automatically Creating Graphical User Interfaces for Command-Line R Packages. Journal of Statistical Software, 2009 Apr; 30(2). PMCID: PMC3103229 252. Hoffmann TJ, Lange C, Vansteelandt S and Laird NM. Gene-environment interaction tests for dichotomous traits in trios and sibships. Genet Epidemiol, 2009 Dec; 33(8):691-9. PMCID: PMC3082448 253. Javaras KN, Laird NM, Hudson JI and Ripley BD. Estimating Disease Prevalence Using Relatives of Case and Control Probands. Biometrics, 2010 Mar;66(1):214-21. PMCID: PMC2933418 254. Ionita-Laza I, Lange C and Laird NM. Estimating the number of unseen variants in the human genome. Proceedings of the National Academy of Sciences of the United States of America, 2009; 106(13): 5008-5013. 255. Murphy JM, Horton NJ, Burke JD, Jr., Monson RR, Laird NM, Lesage A, Sobol

AM. Obesity and weight gain in relation to depression: findings from the Stirling County Study. Int J Obes (Lond), 2009; 33(3): 335-41. PMCID: PMC2656591 256. Sangrajrang S, Sato Y, Sakamoto H, Ohnami S, Laird NM, Khuhaprema T, Brennan P, Boffetta P and Yoshida T. Genetic polymorphisms of estrogen metabolizing enzyme and breast cancer risk in Thai women. Int J Cancer, 2009; 125(4): 837-43. 257. Sato Y, Laird NM, Nagashima K, Kato R, Hamano T, Yafune A, Kaniwa N, Saito Y, Sugiyama E, Kim SR, Furuse J, Ishii H, Ueno H, Okusaka T, Saijo N, Sawada JI and Yoshida T. A new statistical screening approach for finding pharmacokinetics- related genes in genome-wide studies. Pharmacogenomics J, 2009 Apr; 9(2):137- 46. 258. Sato Y, Laird N, Suganami H, Hamada C, Niki N, Yoshimura I, Yoshida T. Statistical screening method for genetic factors influencing susceptibility to common diseases in a two-stage genome-wide association study. Stat Appl Genet Mol Biol. 2009;8(1):Article 46 205. 259. Mansour HA, Talkowski ME, Wood J, Chowdari KV, McClain L, Prasad K, Montrose D, Fagiolini A, Friedman ES, Allen MH, Bowden CL, Calabrese J, El- Mallakh RS, Escamilla M, Faraone SV, Fossey MD, Gyulai L, Loftis JM, Hauser P, Ketter TA, Marangell LB, Miklowitz DJ, Nierenberg AA, Patel J, Sachs GS, Sklar P, Smoller JW, Laird N, Keshavan M, Thase ME, Axelson D, Birmaher B, Lewis D, Monk T, Frank E, Kupfer DJ, Devlin B, Nimgaonkar VL. Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia. Bipolar Disord. 2009 Nov;11(7):701-10. 260. Heid IM, Huth C, Loos RJ, Kronenberg F, Adamkova V, Anand SS, Ardlie K, Biebermann H, Bjerregaard P, Boeing H, Bouchard C, Ciullo M, Cooper JA, Corella D, Dina C, Engert JC, Fisher E, Francès F, Froguel P, Hebebrand J, Hegele RA, Hinney A, Hoehe MR, Hu FB, Hubacek JA, Humphries SE, Hunt SC, Illig T, Järvelin MR, Kaakinen M, Kollerits B, Krude H, Kumar J, Lange LA, Langer B, Li S, Luchner A, Lyon HN, Meyre D, Mohlke KL, Mooser V, Nebel A, Nguyen TT, Paulweber B, Perusse L, Qi L, Rankinen T, Rosskopf D, Schreiber S, Sengupta S, Sorice R, Suk A, Thorleifsson G, Thorsteinsdottir U, Völzke H, Vimaleswaran KS, Wareham NJ, Waterworth D, Yusuf S, Lindgren C, McCarthy MI, Lange C, Hirschhorn JN, Laird N, Wichmann HE. Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design? PLoS Genet. 2009 Oct;5(10):e1000694. Epub 2009 Oct 23.PMCID: PMC2757909 261. Louicharoen C, Patin E, Paul R, Nuchprayoon I, Peerapittayamongkol C, Casademont I, Sura T, Laird NM, Singhasivanon P, Quintana-Murci L, Sakuntabhai Positively selected G6PD-Mahidol mutation reduces plasmodium vivax density in Southeast Asians. Science, 2009; 326(5959):1546-1549. 262. Sangrajrang S, Sato Y, Sakamoto H, Ohnami S, Laird NM, Khuhaprema T,

Brennan P, Boffetta P, Yoshida T. Genetic polymorphisms of estrogen metabolizing enzyme and breast cancer risk in Thai women. Int J Cancer. 2009 Aug 15;125(4):837-43. 263. Javaras KN, Hudson JI, Laird NM. Fitting ACE structural equation models to case- control family data. Genet Epidemiol, 2010 Apr;34(3):238-45. PMCID: PMC2922975. 264. Sato Y, Laird NM, Yoshida T. Biostatistic tools in pharmacogenomics--advances, challenges, potential. Curr Pharm Des. 2010;16(20):2232-40. 265. Fan J, Ionita-Laza I, McQueen MB, Devlin B, Purcell S, Faraone SV, Allen MH, Bowden CL, Calabrese JR, Fossey MD, Friedman ES, Gyulai L, Hauser P, Ketter TB, Marangell LB, Miklowitz DJ, Nierenberg AA, Patel JK, Sachs GS, Thase ME, Molay FB, Escamilla MA, Nimgaonkar VL, Sklar P, Laird NM and Smoller JW. Linkage disequilibrium mapping of the chromosome 6q21-22.31 bipolar I disorder susceptibility locus. Am J Med Genet B Neuropsychiatr Genet, 2010 Jan 5;153B(1):29-37. 205. 266. Hoffmann TJ, Lange C, Bansteelandt S, Raby BA, DeMeo DL, Silverman EK, Weiss ST, Laird NM. Parsing the effects of individual SNP’s in candidate genes with family data. Hum Hered. 2010;69(2):91-103. PMCID: PMC2956011 267. Moreno-Macias H, Romieu I, London SJ, Laird NM. Gene-environment interaction tests for family studies with quantitative phenotypes: A review and extension to longitudinal measures. Hum Genomics. 2010 Jun;4(5):302-26. Review. PMCID: PMC2952941 268. Nan M. Laird. The EM Algorithm in Genetics, Genomics and Public Health. Stat Sci. 2010 25(4):450-457. 269. Sato Y, Laird NM, Yoshida T. Biostatistic tools in pharmacogenomics--advances, challenges, potential. Curr Pharm Des. 2010;16(20):2232-40. Review. PMID: 20459388 270. Vanderweele TJ, Laird NM. Tests for compositional epistasis under single interaction-parameter models. Ann Hum Genet. 2011 Jan;75(1):146-56. PMCID: PMC3413635 271. Sinha SK, Laird NM, Fitzmaurice GM. Multivariate logistic regression with incomplete covariate and auxiliary information. J Multivar Anal. 2010 Nov 1;101(10):2389-2397. PMCID: PMC2952891 272. Cho MHY, Washko GR, Hoffmann TJ, Criner GJ, Hoffman EA, Martinez FJ, Laird N, Reilly JJ, Silverman EK. Cluster analysis in severe emphysema subjects using phenotype and genotype data: en exploratory investigation. Respir Res 2010 Mar;11:30. PMCID: PMC2850331

273. Ionita-Laza I, Laird NM. On the optimal design of genetic variant discovery studies. Stat Appl Genet Mol Biol. 2010;9(1):Article33. Epub 2010 Aug 27. PMCID: PMC 2942028 274. Sato Y, Yamamoto N, Kunitoh H, Ohe Y, Minami H, Laird NM, Katori N, Saito Y, Ohnami S, Sakamoto H, Sawada J, Saijo N, Yoshida T, Tamura T. Genome-wide association study on overall survival of advanced non-small cell lung cancer patients treated with carboplatin and paclitaxel. J Thorac Oncol. 2011 Jan;6(1):132- 8. 275. VanderWeele TJ, Laird NM. Tests for compositional epistasis under single interaction-parameter models. Ann Hum Genet. 2011 Jan;75(1):146-56. PMCID: PMC3413635. 276. Ionita-Laza I, Buxbaum JD, Laird NM, Lange C. A new testing strategy to identify rare variants with either risk or protective effect on disease. PLoS Genet. 2011 Feb 3;7(2):e1001289. PMCID: PMC3033379. 277. Javaras KN, Goldsmith HH, Laird NM. Estimating the effect of a predictor measured by two informants on a continuous outcome: a comparison of methods. Epidemiology. 2011 May;22(3):390-9. PMCID: PMC3073873. 205. 278. Howrigan DP, Laird NM, Smoller JW, Devlin B, McQueen MB. Using linkage information to weight a genome-wide association of bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 2011 Jun;156B(4):462-71. PMCID: PMC3082625. 279. Yoon FB, Fitzmaurice GM, Lipsitz SR, Horton NJ, Laird NM, Normand SL. Alternative methods for testing treatment effects on the basis of multiple outcomes: simulation and case study. Stat Med. 2011 Jul 20;30(16):1917-32. PMCID: PMC3116112. 280. Yip WK, De G, Raby BA, Laird N. Identifying causal rare variants of disease through family-based analysis of Genetics Analysis Workshop 17 data set. BMC Proc. 2011 Nov 29;5 Suppl 9:S21. PMCID: PMC3287856. 281. Ghosh S, Bickeböller H, Bailey J, Bailey-Wilson JE, Cantor R, Culverhouse R, Daw W, Destefano AL, Engelman CD, Hinrichs A, Houwing-Duistermaat J, König IR, Kent J Jr, Laird N, Pankratz N, Paterson A, Pugh E, Suarez B, Sun Y, Thomas A, Tintle N, Zhu X, Ziegler A, Maccluer JW, Almasy L. Identifying rare variants from exome scans: the GAW17 experience. BMC Proc. 2011 Nov 29;5 Suppl 9:S1. PMCID: PMC3287821. 282. Yan A, Laird NM, Li C. Identifying rare variants using a Bayesian regression approach. BMC Proc. 2011 Nov 29;5 Suppl 9:S99. PMCID: PMC3287941. 283. Hoffmann TJ, Vansteelandt S, Lange C, Silverman EK, DeMeo DL, Laird NM.

Combining disease models to test for gene-environment interaction in nuclear families. Biometrics. 2011 Dec;67(4):1260-70. PMCID: PMC3120904 284. Castaldi PJ, Cho MH, Litonjua AA, Bakke P, Gulsvik A, Lomas DA, Anderson W, Beaty TH, Hokanson JE, Crapo JD, Laird N, Silverman EK; COPDGene and Eclipse Investigators. The association of genome-wide significant spirometric loci with chronic obstructive pulmonary disease susceptibility. Am J Respir Cell Mol Biol. 2011 Dec;45(6):1147-53. PMCID: PMC3262664. 285. Sebro R, Lange C, Laird NM, Rogus JJ, Risch NJ. Differentiating population stratification from genotyping error using family data. Ann Hum Genet. 2012 Jan;76(1):42-52. 286. Adhikari K, AlChawa T, Ludwig K, Mangold E, Laird N, Lange C. Is it rare or common? Genet Epidemiol. 2012 Jul;36(5):419-29. PMCID: PMC3641852. 287. Field AE, Sonneville KR, Micali N, Crosby RD, Swanson SA, Laird NM, Treasure J, Solmi F, Horton NJ. Prospective association of common eating disorders and adverse outcomes. Pediatrics. 2012 Aug;130(2):e289-95. PMCID: PMC3408691. 288. Moreno-Macías H, Dockery DW, Schwartz J, Gold DR, Laird NM, Sienra-Monge JJ, Del Río-Navarro BE, Ramírez-Aguilar M, Barraza-Villarreal A, Li H, London SJ, Romieu I. Ozone exposure, vitamin C intake, and genetic susceptibility of asthmatic children in Mexico City: a cohort study. Respir Res. 2013 Feb 4;14:14. PMCID: PMC3579760. 205. 289. Lutz S, Yip WK, Hokanson J, Laird N, Lange C. A general semi-parametric approach to the analysis of genetic association studies in population-based designs. BMC Genet. 2013 Feb 28;14:13. PMCID: PMC3648382. 290. De G, Yip WK, Ionita-Laza I, Laird N. Rare variant analysis for family-based design. PLoS One. 2013;8(1):e48495. PMCID: PMC3546113. 291. Zhou JJ, Cho MH, Castaldi PJ, Hersh CP, Silverman EK, Laird NM. Heritability of chronic obstructive pulmonary disease and related phenotypes in smokers. Am J Respir Crit Care Med. 2013 Oct 15;188(8):941-7. PMCID: PMC3826281. 292. Castaldi PJ, San José Estépar R, Mendoza CS, Hersh CP, Laird N, Crapo JD, Lynch DA, Silverman EK, Washko GR. Distinct quantitative computed tomography emphysema patterns are associated with physiology and function in smokers. Am J Respir Crit Care Med. 2013 Nov 1;188(9):1083-90. PMCID: PMC3863741. 293. Cho MH, McDonald ML, Zhou X, Mattheisen M, Castaldi PJ, Hersh CP, Demeo DL, Sylvia JS, Ziniti J, Laird NM, Lange C, Litonjua AA, Sparrow D, Casaburi R, Barr RG, Regan EA, Make BJ, Hokanson JE, Lutz S, Dudenkov TM, Farzadegan H,

Hetmanski JB, Tal-Singer R, Lomas DA, Bakke P, Gulsvik A, Crapo JD, Silverman EK, Beaty TH; NETT Genetics, ICGN, ECLIPSE and COPDGene Investigators. Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. Lancet Respir Med. 2014 Mar;2(3):214-25. 294. Cho MH, McDonald ML, Zhou X, Mattheisen M, Castaldi PJ, Hersh CP, Demeo DL, Sylvia JS, Ziniti J, Laird NM, Lange C, Litonjua AA, Sparrow D, Casaburi R, Barr RG, Regan EA, Make BJ, Hokanson JE, Lutz S, Dudenkov TM, Farzadegan H, Hetmanski JB, Tal-Singer R, Lomas DA, Bakke P, Gulsvik A, Crapo JD, Silverman EK, Beaty TH. Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. Lancet Respir Med. 2014;2(3):214-25. Epub 2014/03/14. PMCID: PMC4176924. 295. Chu JH, Hersh CP, Castaldi PJ, Cho MH, Raby BA, Laird N, Bowler R, Rennard S, Loscalzo J, Quackenbush J, Silverman EK. Analyzing networks of phenotypes in complex diseases: methodology and applications in COPD. BMC Syst Biol. 2014;8:78. Epub 2014/06/27. PMCID: PMC4105829. 296. Castaldi PJ, Cho MH, San Jose Estepar R, McDonald ML, Laird N, Beaty TH, Washko G, Crapo JD, Silverman EK. Genome-wide association identifies regulatory Loci associated with distinct local histogram emphysema patterns. Am J Respir Crit Care Med. 2014;190(4):399-409. Epub 2014/07/10. PMCID: PMC4214129. 297. Yip WK, Fier H, DeMeo DL, Aryee M, Laird N, Lange C. A novel method for detecting association between DNA methylation and diseases using spatial information. Genet Epidemiol. 2014;38(8):714-21. Epub 2014/09/25. PMCID: PMC4236268. 205. 298. Zhou JJ, Yip WK, Cho MH, Qiao D, McDonald ML, Laird NM. A comparative analysis of family-based and population-based association tests using whole genome sequence data. BMC Proc. 2015;8(Suppl 1 Genetic Analysis Workshop 18Vanessa Olmo):S33. Epub 2014/12/19. PMCID: PMC4143682. 299. Cho MH, Castaldi PJ, Hersh CP, Hobbs BD, Barr RG, Tal-Singer R, Bakke P, Gulsvik A, San Jose Estepar R, Van Beek EJ, Coxson HO, Lynch DA, Washko GR, Laird NM, Crapo JD, Beaty TH, Silverman EK. A Genome-Wide Association Study of Emphysema and Airway Quantitative Imaging Phenotypes. Am J Respir Crit Care Med. 2015;192(5):559-69. Epub 2015/06/02. PMID: 26030696. PMCID: PMC4595690. 300. Zhou JJ, Cho MH, Lange C, Lutz S, Silverman EK, Laird NM. Integrating Multiple Correlated Phenotypes for Genetic Association Analysis by Maximizing Heritability. Hum Hered. 2015;79(2):93-104. Epub 2015/06/27. PMCID: PMC4508328. 301. DerSimonian R, Laird N. Meta-Analysis in Clinical Trials Revisited. Contemp Clin Trials. 2015. Epub 2015/09/08. PMID: 26343745.

302. Qiao D, Lange C, Laird NM, Won S, Hersh CP, Morrow J, Hobbs BD, Lutz SM, Ruczinski I, Beaty TH, Silverman EK, Cho MH. Gene-based segregation method for identifying rare variants in family-based sequencing studies. Genet Epidemiol. 2017 Feb 13. doi: 10.1002/gepi.22037. [Epub ahead of print] PMID: 28191685. 303. Sato Y, Gosho M, Nagashima K, Takahashi S, Ware JH, Laird NM. Statistical Methods in the Journal - An Update. N Engl J Med. 2017 Mar 16;376(11):1086- 1087. doi: 10.1056/NEJMc1616211. No abstract available. PMID: 28296608 304. Gene-based segregation method for identifying rare variants in family-based sequencing studies. Qiao D, Lange C, Laird NM, Won S, Hersh CP, Morrow J, Hobbs BD, Lutz SM, Ruczinski I, Beaty TH, Silverman EK, Cho MH.Genet Epidemiol. 2017 May;41(4):309-319. doi: 10.1002/gepi.2203 305. Genome-Wide Association Study of the Genetic Determinants of Emphysema Distribution. Boueiz A, Lutz SM, Cho MH, Hersh CP, Bowler RP, Washko GR, Halper-Stromberg E, Bakke P, Gulsvik A, Laird NM, Beaty TH, Coxson HO, Crapo JD, Silverman EK, Castaldi PJ, DeMeo DL; COPDGene and ECLIPSE Investigators. Am J Respir Crit Care Med. 2017;195(6):757-771. doi: 10.1164/rccm.201605-0997OC. 306. Sex-based genetic association study identifies CELSR1 as a possible chronic obstructive pulmonary disease risk locus among women. Megan Hardin, Michael H Cho, Sunita Sharma, Kimberly Glass, Peter J Castaldi, Merry-Lynn McDonald, Hugues Aschard, Jody Senter-Sylvia, Kelan Tantisira, Scott T Weiss, Craig P Hersh, Jarrett D Morrow, David Lomas, Alvar Agusti, Per Bakke, Amund Gulsvik, George T O’Connor, Josée Dupuis, John Hokanson, James D Crapo, Terri H Beaty, Nan Laird, Edwin K Silverman, Dawn L DeMeo. American Journal of Respiratory Cell and Molecular Biology 56(3), 2017:332-341. 307. Whole Exome Sequencing Analysis Of Severe COPD. C Lange, TH Beaty, JD Crapo, NM Laird, BD Hobbs, R Busch, D Lomas, Y Liu, M Spitz, A Agusti, BJD Qiao, EK Tal-Singer, MH C. Am J Respir Crit Care Med,195 2017: A4965 308. Damaging Missense De Novo Coding Mutations Contribute To Schizophrenia Risk Daniel Howrigan, Kaitlin Samocha, Jack Kosmicki, Jennifer Moran, Kimberly Chambert, Menachem Fromer, Sharon Chandler, Nan Laird, Hai-Gwo Hwu, Wei J Chen, Stephen Faraone, Stephen Glatt, Ming Tsuang, Steven McCarroll, Benjamin Neale. European Neuropsychopharmacology, 27, 2017: S427-S428. 309. C21 OMICS IN LUNG DISEASE: Whole Exome Sequencing Analysis Of Severe COPD. D Qiao, C Lange, TH Beaty, JD Crapo, NM Laird… - American Journal of Respiratory and Critical Car195, 2017. 310. Laird, Nan M and Lange, Christoph (April 2018) Family-based Association Test

(FBAT). In: eLS. John Wiley & Sons, Ltd: Chichester. DOI: 10.1002/9780470015902.a0022500.pub2 COPDgene Investigator's Group or ECLIPSE Study Group Publications 1. Kim DK, Hersh CP, Washko GR, Hokanson JE, Lynch DA, Newell JD, Murphy JR, Crapo JD, Silverman EK; COPD Gene Investigators. Epidemiology, radiology, and genetics of nicotine dependence in COPD. Respir Res. 2011 Jan 13;12:9. PMCID: PMC3033825 2. Washko GR, Hunninghake GM, Fernandez IE, Nishino M, Okajima Y, Yamashiro T, Ross JC, Estépar RS, Lynch DA, Brehm JM, Andriole KP, Diaz AA, Khorasani R, D'Aco K, Sciurba FC, Silverman EK, Hatabu H, Rosas IO; COPDGene Investigators. Lung volumes and emphysema in smokers with interstitial lung abnormalities. N Engl J Med. 2011 Mar 10;364(10):897-906. PMCID: PMC3074462. 3. Foreman MG, Zhang L, Murphy J, Hansel NN, Make B, Hokanson JE, Washko G, Regan EA, Crapo JD, Silverman EK, DeMeo DL; COPDGene Investigators. Early- onset chronic obstructive pulmonary disease is associated with female sex, maternal factors, and African American race in the COPDGene Study. Am J Respir Crit Care Med. 2011 Aug 15;184(4):414-20. PMCID: PMC3175544. 1. 4. Hardin M, Silverman EK, Barr RG, Hansel NN, Schroeder JD, Make BJ, Crapo JD, Hersh CP; COPDGene Investigators. The clinical features of the overlap between COPD and asthma. Respir Res. 2011 Sep 27;12:127. PMCID: PMC3204243. 5. Siedlinski M, Cho MH, Bakke P, Gulsvik A, Lomas DA, Anderson W, Kong X, Rennard SI, Beaty TH, Hokanson JE, Crapo JD, Silverman EK; COPDGene Investigators; ECLIPSE Investigators. Genome-wide association study of smoking behaviours in patients with COPD. Thorax. 2011 Oct;66(10):894-902. PMCID: PMC3302576. 6. Han MK, Kazerooni EA, Lynch DA, Liu LX, Murray S, Curtis JL, Criner GJ, Kim V, Bowler RP, Hanania NA, Anzueto AR, Make BJ, Hokanson JE, Crapo JD, Silverman EK, Martinez FJ, Washko GR; COPDGene Investigators. Chronic obstructive pulmonary disease exacerbations in the COPDGene study: associated radiologic phenotypes. Radiology. 2011 Oct;261(1):274-82. PMCID: PMC3184233. 7. Cho MH, Castaldi PJ, Wan ES, Siedlinski M, Hersh CP, Demeo DL, Himes BE, Sylvia JS, Klanderman BJ, Ziniti JP, Lange C, Litonjua AA, Sparrow D, Regan EA, Make BJ, Hokanson JE, Murray T, Hetmanski JB, Pillai SG, Kong X, Anderson WH, Tal-Singer R, Lomas DA, Coxson HO, Edwards LD, MacNee W, Vestbo J, Yates JC, Agusti A, Calverley PM, Celli B, Crim C, Rennard S, Wouters E, Bakke P, Gulsvik A, Crapo JD, Beaty TH, Silverman EK; ICGN Investigators; ECLIPSE Investigators;

COPDGene Investigators. A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. Hum Mol Genet. 2012 Feb 15;21(4):947-57. PMCID: PMC3298111. 8. Rambod M, Porszasz J, Make BJ, Crapo JD, Casaburi R; COPDGene Investigators. Six-minute walk distance predictors, including CT scan measures, in the COPDGene cohort. Chest. 2012 Apr;141(4):867-75. PMCID: PMC3318949. 9. Martinez CH, Chen YH, Westgate PM, Liu LX, Murray S, Curtis JL, Make BJ, Kazerooni EA, Lynch DA, Marchetti N, Washko GR, Martinez FJ, Han MK; COPDGene Investigators. Relationship between quantitative CT metrics and health status and BODE in chronic obstructive pulmonary disease. Thorax. 2012 May;67(5):399-406. PMCID: PMC3719874. 10. Wells JM, Washko GR, Han MK, Abbas N, Nath H, Mamary AJ, Regan E, Bailey WC, Martinez FJ, Westfall E, Beaty TH, Curran-Everett D, Curtis JL, Hokanson JE, Lynch DA, Make BJ, Crapo JD, Silverman EK, Bowler RP, Dransfield MT; COPDGene Investigators; ECLIPSE Study Investigators. Pulmonary arterial enlargement and acute exacerbations of COPD. N Engl J Med. 2012 Sep 6;367(10):913-21. PMCID: PMC3690810. 11. Zach JA, Newell JD Jr, Schroeder J, Murphy JR, Curran-Everett D, Hoffman EA, Westgate PM, Han MK, Silverman EK, Crapo JD, Lynch DA; COPDGene Investigators. Quantitative computed tomography of the lungs and airways in healthy nonsmoking adults. Invest Radiol. 2012 Oct;47(10):596-602. PMCID: PMC3703944. 1. 12. Kim DK, Cho MH, Hersh CP, Lomas DA, Miller BE, Kong X, Bakke P, Gulsvik A, Agustí A, Wouters E, Celli B, Coxson H, Vestbo J, MacNee W, Yates JC, Rennard S, Litonjua A, Qiu W, Beaty TH, Crapo JD, Riley JH, Tal-Singer R, Silverman EK; ECLIPSE, ICGN, and COPDGene Investigators. Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2012 Dec 15;186(12):1238-47. PMCID: PMC3622441. 13. Hansel NN, Washko GR, Foreman MG, Han MK, Hoffman EA, DeMeo DL, Barr RG, Van Beek EJ, Kazerooni EA, Wise RA, Brown RH, Black-Shinn J, Hokanson JE, Hanania NA, Make B, Silverman EK, Crapo JD, Dransfield MT; COPDGene Investigators. Racial differences in CT phenotypes in COPD. COPD. 2013 Feb;10(1):20-7. 14. Hersh CP, Washko GR, Estépar RS, Lutz S, Friedman PJ, Han MK, Hokanson JE, Judy PF, Lynch DA, Make BJ, Marchetti N, Newell JD Jr, Sciurba FC, Crapo JD, Silverman EK; COPDGene Investigators. Paired inspiratory-expiratory chest CT scans to assess for small airways disease in COPD. Respir Res. 2013 Apr 8;14:42. PMCID: PMC3627637.

15. Siedlinski M, Tingley D, Lipman PJ, Cho MH, Litonjua AA, Sparrow D, Bakke P, Gulsvik A, Lomas DA, Anderson W, Kong X, Rennard SI, Beaty TH, Hokanson JE, Crapo JD, Lange C, Silverman EK; COPDGene and ECLIPSE Investigators. Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility. Hum Genet. 2013 Apr;132(4):431-41. PMCID: PMC3600068. 16. Bowler RP, Kim V, Regan E, Williams AA, Santorico SA, Make BJ, Lynch DA, Hokanson JE, Washko GR, Bercz P, Soler X, Marchetti N, Criner GJ, Ramsdell J, Han MK, Demeo D, Anzueto A, Comellas A, Crapo JD, Dransfield M, Wells JM, Hersh CP, MacIntyre N, Martinez F, Nath HP, Niewoehner D, Sciurba F, Sharafkhaneh A, Silverman EK, van Beek EJ, Wilson C, Wendt C, Wise RA. Prediction of acute respiratory disease in current and former smokers with and without COPD. Chest. 2014;146(4):941-50. Epub 2014/06/20. PMCID: PMC4188150. 17. Hobbs BD, Foreman MG, Bowler R, Jacobson F, Make BJ, Castaldi PJ, San Jose Estepar R, Silverman EK, Hersh CP. Pneumothorax risk factors in smokers with and without chronic obstructive pulmonary disease. Ann Am Thorac Soc. 2014;11(9):1387-94. Epub 2014/10/09. PMCID: PMC4298989. 18. Hersh CP, Make BJ, Lynch DA, Barr RG, Bowler RP, Calverley PM, Castaldi PJ, Cho MH, Coxson HO, DeMeo DL, Foreman MG, Han MK, Harshfield BJ, Hokanson JE, Lutz S, Ramsdell JW, Regan EA, Rennard SI, Schroeder JD, Sciurba FC, Steiner RM, Tal-Singer R, van Beek E, Jr., Silverman EK, Crapo JD. Non- emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus. BMC Pulm Med. 2014;14:164. Epub 2014/10/25. PMCID: PMC4216374. 1. 19. Kim V, Desai P, Newell JD, Make BJ, Washko GR, Silverman EK, Crapo JD, Bhatt SP, Criner GJ. Airway wall thickness is increased in COPD patients with bronchodilator responsiveness. Respir Res. 2014;15:84. Epub 2014/09/25. PMCID: PMC4198908. 20. Lee JH, Cho MH, McDonald ML, Hersh CP, Castaldi PJ, Crapo JD, Wan ES, Dy JG, Chang Y, Regan EA, Hardin M, DeMeo DL, Silverman EK. Phenotypic and genetic heterogeneity among subjects with mild airflow obstruction in COPDGene. Respir Med. 2014;108(10):1469-80. Epub 2014/08/27. PMCID: PMC4253548. 21. Lee JH, McDonald ML, Cho MH, Wan ES, Castaldi PJ, Hunninghake GM, Marchetti N, Lynch DA, Crapo JD, Lomas DA, Coxson HO, Bakke PS, Silverman EK, Hersh CP. DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease. Respir Res. 2014;15:97. Epub 2014/08/20. PMCID: PMC4169636. 22. McDonald ML, Cho MH, Sorheim IC, Lutz SM, Castaldi PJ, Lomas DA, Coxson HO, Edwards LD, MacNee W, Vestbo J, Yates JC, Agusti A, Calverley PM, Celli B, Crim C, Rennard SI, Wouters EF, Bakke P, Tal-Singer R, Miller BE, Gulsvik A, Casaburi R, Wells JM, Regan EA, Make BJ, Hokanson JE, Lange C, Crapo JD, Beaty TH, Silverman EK, Hersh CP. Common genetic variants associated with resting oxygenation in chronic

obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2014;51(5):678-87. Epub 2014/05/16. PMCID: PMC4224086. 23. Wan ES, Castaldi PJ, Cho MH, Hokanson JE, Regan EA, Make BJ, Beaty TH, Han MK, Curtis JL, Curran-Everett D, Lynch DA, DeMeo DL, Crapo JD, Silverman EK. Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene. Respir Res. 2014;15:89. Epub 2014/08/07. PMCID: PMC4256936. 24. Kim V, Crapo J, Zhao H, Jones PW, Silverman EK, Comellas A, Make BJ, Criner GJ. Comparison between an alternative and the classic definition of chronic bronchitis in COPDGene. Ann Am Thorac Soc. 2015;12(3):332-9. Epub 2015/01/13. PMCID: PMC4418311. 25. Jaramillo JD, Wilson C, Stinson DS, Lynch DA, Bowler RP, Lutz S, Bon JM, Arnold B, McDonald ML, Washko GR, Wan ES, DeMeo DL, Foreman MG, Soler X, Lindsay SE, Lane NE, Genant HK, Silverman EK, Hokanson JE, Make BJ, Crapo JD, Regan EA. Reduced Bone Density and Vertebral Fractures in Smokers. Men and COPD Patients at Increased Risk. Ann Am Thorac Soc. 2015;12(5):648-56. Epub 2015/02/27. PMCID: PMC4418341. 26. Lee JH, Cho MH, Hersh CP, McDonald ML, Wells JM, Dransfield MT, Bowler RP, Lynch DA, Lomas DA, Crapo JD, Silverman EK. IREB2 and GALC are associated with pulmonary artery enlargement in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2015;52(3):365-76. Epub 2014/08/08. PMCID: PMC4370263. 1. 27. Lutz SM, Cho MH, Young K, Hersh CP, Castaldi PJ, McDonald ML, Regan E, Mattheisen M, DeMeo DL, Parker M, Foreman M, Make BJ, Jensen RL, Casaburi R, Lomas DA, Bhatt SP, Bakke P, Gulsvik A, Crapo JD, Beaty TH, Laird NM, Lange C, Hokanson JE, Silverman EK; ECLIPSE Investigators.; COPDGene Investigators. A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. BMC Genet. 2015 Dec 3;16:138. doi: 10.1186/s12863-015-0299-4. PMID: 26634245. PMCID: PMC4668640. 28. Cho MH, Castaldi PJ, Hersh CP, Hobbs BD, Barr RG, Tal-Singer R, Bakke P, Gulsvik A, San José Estépar R, Van Beek EJ, Coxson HO, Lynch DA, Washko GR, Laird NM, Crapo JD, Beaty TH, Silverman EK; NETT Genetics, ECLIPSE, and COPDGene Investigators. A Genome-Wide Association Study of Emphysema and Airway Quantitative Imaging Phenotypes. Am J Respir Crit Care Med. 2015 Sep 1;192(5):559-69. doi: 10.1164/rccm.201501-0148OC. PMID: 26030696. 29. Hobbs BD, Parker MM, Chen H, Lao T, Hardin M, Qiao D, Hawrylkiewicz I, Sliwinski P, Yim JJ, Kim WJ, Kim DK, Castaldi PJ, Hersh CP, Morrow J, Celli BR, Pinto-Plata VM, Criner GJ, Marchetti N, Bueno R, Agustí A, Make BJ, Crapo JD, Calverley PM, Donner CF, Lomas DA, Wouters EF, Vestbo J, Paré PD, Levy RD, Rennard SI, Zhou X, Laird NM, Lin X, Beaty TH, Silverman EK, Cho MH; NETT Genetics

Investigators.; ECLIPSE Investigators.; COPDGene Investigators.; International COPD Genetics Network Investigators. Exome Array Analysis Identifies a Common Variant in IL27 Associated with Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2016 Jul 1;194(1):48-57. doi: 10.1164/rccm.201510-2053OC. PMID: 26771213. PMCID: PMC4960630. 30. Boueiz A, Lutz SM, Cho MH, Hersh CP, Bowler RP, Washko GR, Halper- Stromberg E, Bakke P, Gulsvik A, Laird NM, Beaty TH, Coxson HO, Crapo JD, Silverman EK, Castaldi PJ, DeMeo DL; COPDGene and ECLIPSE Investigators. Genome-Wide Association Study of the Genetic Determinants of Emphysema Distribution. Am J Respir Crit Care Med. 2017 Mar 15;195(6):757-771. doi: 10.1164/rccm.201605-0997OC. PMID: 27669027. Books, Book Chapters and Monographs: 1. Laird NM. Analysis of Longitudinal and Cluster-Correlated Data. NSF- CBMS.Regional Conference Series in Probability and Statistics, Volume 8. Published by the Institute of Mathematical Statistics and the American Statistical Association. 2004. 2. Fitzmaurice GM, Laird NM and Ware JH. Applied Longitudinal Analysis. Wiley- Interscience: Hoboken, N.J. 2004. 3. Laird, NM and Lange, C. Introduction to Modern Methods of Statistical Genetics. Springer, 2011 1. 4. Laird, NM and M Zelen. ‘Harvard University Department of Biostatistics’ In Strength in Numbers: The Rising of Academic Statistics Departments in the U.S.’ A. Agresti and X-L Meng, Eds. Springer, 2012. Letters and Comments: 1. Thurston G and Laird N. “Tracing aerosol pollution.” Science, 1985; 227:1406-8. 2. Laird NM and Maher EH. “Discussion on `A Statistical Model for PET'.” Journal of the American Statistical Association, 1985; 80:29-30. 3. Laird NM and Louis TA. “Discussion on `Statistical Modelling of School Effectiveness Data'.” Journal of the Royal Statistical Society, Series A, 1986; 149:37. 4. Laird NM and Lange N. “Discussion of `Prediction of Future Observations in Growth Curve Models' by C.R. Rao.” Statistical Science, 1987; 2:434-471. 5. Laird NM, Patil GP, and Taillie C. “Discussion of `Selection Models and the file- drawer problem'~” by S. Iyengar and J. Greenhouse. Statistical Science, 1988; 3:126-128.

6. Laird NM and Mosteller F. “Discussion of `Publication Bias: A Problem in Interpreting Medical Data'.” Journal of the Royal Statistical Society, Series A, 1988; 151:456. 7. Laird NM. “Discussion of `The Effects of Rehabilitation Therapy for Aphasia'.” In The Future of Meta-Analysis. Kenneth W. Wachter and Miron L. Straf, eds. Russell Sage Press, 1989. 8. Laird NM. “Discussion of `A smoothed EM approach to indirect estimation problems, with reference to stereology and emission tomography.” Journal of the Royal. Statistical Society, B, 1990; 52:316. 9. Blacker D, Wilcox MA, Laird NM, Rodes L, Horvath SM, Go RCP, Perry R, Watson B Jr., Bassett SS, McInnis MG, Albert MS, Hyman BT, and Tanzi R. “Alpha-2 macroglobulin is genetically associated with Alzheimer Disease.” Nature Genetics, 1998; 19:357-360. 10. Laird NM, Blacker D and Wilcox MA. “The S-TDT is a Mantel Haenszel Test.” American Journal of Human Genetics, 1998; 63:1915. 11. Laird NM and Pauler DK. “Discussion of `Adjusting for Non-ignorable Drop-out Using Semiparametric Non-response Models' by D.O. Scharfstein, A. Rotnitzky, and J.M. Robins.” Journal of the American Statistical Association, 1999; 94:1133- 1135. 1. 12. Comments on 'Empirical vs natural weighting in random effects meta-analysis'. Laird N, Fitzmaurice G, Ding X. Stat Med. 2010 May 30;29(12):1266-7; discussion 1272-81. No abstract available. Invited Talks, Seminars and Short Courses: International Biometrics Society and American Statistical Association, Boston, MA, August 1976. Research Section Meeting, Royal Statistical Society, London, December 1976. Department of Biomathematics, UCLA, Los Angeles, CA, May 1976. Langley Research Center NASA, Hampton, Virginia, January 1977. Biometric Society (ENAR) and American Statistical Association, Chapel Hill, N.C., April 1977. Massachusetts Eye and Ear E.N.T. Staff Associates, March 1977. Department of Statistics, University of Pennsylvania, February 1978. Fifth International Symposium on Multivariate Analysis, Pittsburgh, PA, June 1978. Biomathematics Department Seminar, UCLA, February 1979. Mathematics Department, University of California at Santa Barbara, February 1979. Woman's Center, University of California at Santa Barbara, February 1979.

School of Statistics, University of Minnesota, January 17, 1980. School of Public Health, University of Minnesota, January 18, 1980. Department of Statistics, University of Glasgow, Glasgow, Scotland, February 27, 1980. University of Lancaster, Lancaster, England, Series of Lectures, Spring, 1980. Biometrics Society Annual Meetings, Houston, TX, August 1980. Biometrics Society Annual Meetings, Detroit MI, August 1981. University of North Carolina, Chapel Hill, N.C., March 1982. NHLBI Mathematical Statistics Group, Washington, D.C., March 1982. JASA Applications Talk, Annual Meetings, Cincinnati, Ohio, August 1982. International Biometrics Society Annual Meeting, Toulouse, France, September 1982. Biometrics ENAR Spring Regional Meetings, Nashville, TN, March 1983. Educational Testing Service, Princeton, NJ, April 1983. Biostatistics Public Affairs Seminar, Harvard University, April 1983. Harvard School of Public Health, June 10, 1983. Short course on Longitudinal Data Annual Meeting, American Statistical Association, Toronto, August 1983. Carnegie-Mellon University, Pittsburgh, PA, November 1983. Statistics Seminar, Educational Testing Service, Princeton, NJ, February 1984. Statistics Seminar, State University of New York, Albany, NY, March 1984. Mathematics Department, Mt. Holyoke College, South Hadley, MA, April l984. Seminar on Statistics and the Environment, Mt. Holyoke College, South Hadley, MA, April 1984. NHLBI, Washington, D.C., June 4-5, 1984. American Statistical Association Annual Meetings, Philadelphia, PA, August 1984. Seminar, School of Public Health, Columbia University, November 1984. Regional Spring Meetings, Biometric Society ENAR, Chapel Hill, N.C., March 1985. Annual Meetings, American Statistical Association, Las Vegas, August 1985. Annual Meetings, Biometrics Society (WNAR), Seattle, August 1985. NHLBI, Bethesda, September 1986. Johns Hopkins University, November 1986. 1986 Annual Meeting of the Society for Risk Analysis, Boston, MA, November 1986. International Symposium on Advances in Statistical Methods for the Genetic Improvement of Livestock, Armidale, Australia, February 1987. Sydney University, Australia, February 1987. Iowa State University, Ames, Iowa, October 1987. University of Massachusetts, Amherst, November 1987. ASA and ENAR Spring Meetings, Boston, MA, March 1988. University of Michigan, Department of Biostatistics, Spring, 1988. Boston Chapter of ASA, Boston, MA, May 1988. Cornell University, Ithaca, NY, June 1988. ASA Annual Meetings, Washington, D.C., August 1989. International Conference on Longitudinal Data Analysis, Bressanone, Italy, 1989. Department of Psychiatry, Massachusetts General Hospital, Boston, MA, February 1990. Department of Statistics, Yale University, April 1990.

Department of Statistics, Penn State University, College Park, PA, April 1990. Department of Epidemiology and Biometry, University of Colorado Health Sciences Center, Denver, Colorado, May 1990. Mathematics Department, Lancaster University, Lancaster, England, June 1990. Department of Statistics, University of Chicago, Chicago, IL, December 1990. Department of Statistics, University of Wisconsin, Madison, WI, December 1990. Conference on Statistical Models for Longitudinal Data, Mathematisches Forschungsinstitut, Oberwolfach, Germany, February 1991. New England Statistics Day, Storrs, CT, April 1991. Symposium on Longitudinal Data Analysis, Fort Lauderdale, FL, June 1991. Boston University, October 1991. Columbia University, New York, November 1991. Annual Meetings, Society for Clinical Trials, Philadelphia, PA, May 1992. Short Course, sponsored by the Nordic Research Council, Helsinki, June 1992. Special Invited Paper, IMS Annual Meetings, Boston, MA, August 1992. Special Meeting of the Institute of Mathematical Statistics on Likelihood Inference,University Park, PA, October 1992. Department of Biostatistics, School of Public Health, UNC, Chapel Hill, NC, December 1992. Institute of Statistics and Decision Sciences, Duke University, Durham, NC, December 1992. Australian National University, Canberra, ACT, University of Sydney, Sydney, Australia and University of Newcastle, Center for Clinical Biostatistics and Epidemiology, Newcastle, Australia, March 1993. ASA Delaware Chapter, University of Delaware, April 1993. Canadian Statistical Society, Ottawa, October 1993. NCI, Division of Cancer Prevention and Control Seminar, Bethesda, MD, June 1994. INSERM Workshop on the Analysis of Correlated Binary Data, Le Vèsinet, France, June 1994. Sèminar Europèen de Statistique, Oxford, England,1994. Workshop on Statistical Methods for Incomplete Covariate Data in Clinical and Epidemiological Studies, Freiburg, Germany, February 1995. Workshop, Bristol-Myers Squibb, Wallingford, CT, March 1995. ENAR Spring Meetings, Birmingham, Alabama, March 1995. Seventh Annual Charles Odoroff Memorial Lecture, University of Rochester, April 1995. Workshop, Pfizer Research, Groton, CT, June 1995. Department of Mathematics, University of Memphis, TN, June 1995. National Growth and Health Study Workshop, Bethesda, MD, June 1995. Boston Chapter of the American Statistical Association, December 1995. Department of Statistics, University of Texas, Austin, TX, April 1996. Department of Biomathematics, University of Texas Medical School, Houston, TX, April 1996. Department of Statistics, Limburgs University, Belgium, June 1996. Nuffield College, Oxford University, Oxford, England, June 1996. NSF Workshop on Modeling,

Nantucket, MA, October 1996. NSF, Department of Mental Hygiene, Johns Hopkins University, Baltimore, MD, September 1996. Biostatistics Research, Schering-Plough Pharmaceutical, Kenilworth, NJ, November 1996. FDA, Short Course on Longitudinal Data Analysis, Bethesda, MD, April 1997. Department of Mental Hygiene, Workshop on Prevention Studies, Johns Hopkins School of Public Health, April 1997. Cleveland Clinic and Department of Statistics Colloquium, Case Western University, Cleveland, Ohio, May 1997. CBMS/NSF Longitudinal Data Analysis Conference, Keynote Speaker, University of Missouri, Columbia, MO, June 1997. WNAR Presidential Invited Address, Park City, Utah, July 1997. ASA Annual Meetings, Anaheim, California, August 1997. Workshop on Missing Data, Keynote Speaker, University of Ghent, Belgium, September 1997. Department of Statistics Fiftieth Anniversary Symposium, Iowa State University, Ames, Iowa, October 1997. Pfizer Research Workshop on Molecular Biology, New London, Connecticut, October 1997. ASA New Jersey Chapter, Spring Symposium on Mixed Models, June 1998. Invited Speaker, Department of Biostatistics, Sloan Kettering Research Institute, New York, NY, December 1998. Invited Speaker, Department of Statistics, Carnegie Mellon University, Pittsburgh, Pennsylvania, March 1999. Invited Speaker, INSERM, Paris, France, June 2000. Invited Speaker, Biannual Symposium, Department of Biostatistics, University of Washington, Seattle, Washington, November 2000. Invited Speaker, Department of Community Medicine, Brown University, Providence, Rhode Island, November 2000. Centers for Disease Control (CDC) Special Symposium on Analysis of Large Data Sets, Atlanta, Georgia, January 2001. Invited Speaker, Annual Meeting, Canadian Statistical Society, Vancouver, Canada, June 2001. Seminar, Pfizer Research, Grafton, CT, April 2002. Invited Speaker, Special Conference on Biostatistical Methods in Alzheimer's Disease, Louisville, KY, May 2002. Invited Speaker, 17th Annual European Statistical Modeling Workshop, Hania, Greece, July 2002. Invited Speaker, Special Session on Statistical Genetics, Annual Meeting of the American Statistical Association, New York, NY, August 2002. Invited Speaker, Scandinavian Symposium on Genetics, Stockholm, Sweden, September 2002. Seminar Series, National Institutes of Public Health, Cuernavaca, Mexico, February

2003. Award Presentation, Janet Norwood Prize, Birmingham, AL, October 2003. Invited Speaker, Seminar Series, Departments of Biostatistics and Epidemiology, University of Pennsylvania, PA, November 2003 Invited Speaker, Statistics Department, Perdue Univesity, 2004 Invited Speaker, National Human Genome Research Institute, April, 2006 Invited Speaker, Statistics Department, Yale University, 2006 Invited Speaker, Session on Statistical Genetics, Annual Meetings of American Statistical Association, 2006 Invited Speaker, Department of Human Genetics, UCLA, 2007 Invited Speaker, Amer. Assoc. Cancer Research Annual Conference, Taos, NM 2007 Invited Speaker, Amer. Assoc. Cancer Research Annual Conference, Tuscon AZ, 2008 Invited Speaker, Department of Human Genetics, UCLA, 2009 Invited Speaker, Department of Statistics, Columbia University, 2010 Invited Speaker, Department of Statistics, Yale University, 2010 Invited Speaker, Statistical Modeling Conference, Brisbane U., Queensland Au, 2010 Invited Speaker, Department of Statistics, University of Kyoto, Kyoto, Japan, March 2012 Keynote Speaker, Department of Statistics, Conference on Biostatistics, University of Tokyo, Tokyo, Japan March 2010 Short Courses since 2002 (outside of Harvard) Short Course in Longitudinal Analysis, Kitasato University, Tokyo, Japan, March 2002 Short Course on Genetic Association Analysis, Karolinski Institute, Sweden, March 2004 Short Course on Genetic Association Analysis, Gent University, Belgium, 2006 Short Course in Longitudinal Analysis, Deming Conference, Atlantic City, NJ, Nov 2006 Short Course in Longitudinal Analysis, American Statistical Association, Alexandria, VA, October 2006 Short Course on Genetic Association Analysis, University of Denver at Boulder, October 2007, 2009 Short Course on Genetic Association Analysis, Annual Meeting, Institute for Clinical Biostatistics, Alexandropoulis, Greece, September 2007 Short Course on Genetic Association Analysis, CSIRO, Sydney Australia, 2010 Short Course on Fundamentals of Statistical Genetics, ASA, Miami, 2011 Short Course on Software for Family Based Association Studies, Taipei Taiwan, April 2012 Short Course on Genetic Association Analysis, Tiekyo University, Tokyo, Japan, January 2013 and January 2014.