Human Genetic Mutations. 2 Main Types of Mutations 1.) Chromosomal Mutations 2.) Gene Mutations.
Mutations
Transcript of Mutations
13.3 Mutations
Gene Mutations
• Mutation – change in the genetic material of a cell
• Point mutations–Changes in one or a few nucleotides– Insertions, deletions, substitutions
• Frameshift mutations–Reading frame of the genetic code is shifted– Insertions and deletions are examples
Chromosomal Mutations
• Change in the number or structure of chromosomes
• Can change location of genes on chromosomes, or the number of copies of some genes
• Four types are: deletion, duplication, inversion, and translocation (see page 318)
Effects of Mutations• Chemical or physical agents in the
environment that can alter genetic material
• Can help or harm organisms, although most have little or no effect
• Chemical mutagens can include: pesticides, tobacco smoke, and pollutants
• Physical mutagens can include: x-rays and ultraviolet light
Example
• Sickle cell anemia (see page 318)–Caused by point mutation–Causes red blood cells to change shape–Sickle-shaped cells interfere with blood
flow and can cause severe problems in bloodstream