Moinak's Presentation_Meter Dose Drug Delivery Device.

8/14/2019 Moinak's Presentation_Meter Dose Drug Delivery Device.

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TOPIC OF SEMINARTOPIC OF SEMINAR

METER DOSE DRUG DELIVERY DEVICEMETER DOSE DRUG DELIVERY DEVICE


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INTRODUCTIONINTRODUCTION

DRUG DELIVERY DEVICE(DDD):DRUG DELIVERY DEVICE(DDD):These are the devices which are used to delivery various types of drugsThese are the devices which are used to delivery various types of drugs

into the human body.This devices are used to deliver the drugs in forminto the human body.This devices are used to deliver the drugs in formof injection,injestion,absorption.This devices showed a new path to theof injection,injestion,absorption.This devices showed a new path to the

Bio-Medical field.Bio-Medical field.

METER DOSE DRUG DELIVERY DEVICE(MDD):METER DOSE DRUG DELIVERY DEVICE(MDD):They areThey arepressurized,hand-held devices that use propellents to deliver doses ofpressurized,hand-held devices that use propellents to deliver doses of

medications to the lungs of a patient.These delivey devices are criticallymedications to the lungs of a patient.These delivey devices are criticallyimportant to public health and are used to administer various medications for aimportant to public health and are used to administer various medications for arange of medical conditions.MDDs plays a significant role in the treatment ofrange of medical conditions.MDDs plays a significant role in the treatment ofasthma and chronic obstructive pulmonary disease(COPD).MDDs are primaryasthma and chronic obstructive pulmonary disease(COPD).MDDs are primaryDDDs used world-wide for asthma and COPD.DDDs used world-wide for asthma and COPD.


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TYPES OF METER DOSE DRUGTYPES OF METER DOSE DRUG

DELIVERY DEVICESDELIVERY DEVICES

Different types of devices are used to deliverDifferent types of devices are used to deliverinhaled medications into the lung:-inhaled medications into the lung:-

i)INHALERS:i)INHALERS:

Inhalers are small pocket-sized containers thatInhalers are small pocket-sized containers thatenable us to inhale the madications inform ofenable us to inhale the madications inform of

powder or spray.powder or spray.

There are two types of inhalers:-There are two types of inhalers:-

A)Meter-dose(sometimes used with spacers).A)Meter-dose(sometimes used with spacers).

B)Dry powder.B)Dry powder.


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TYPES OF METER-DOSE DRUGTYPES OF METER-DOSE DRUG

DELIVERY DEVICE(CONTD)DELIVERY DEVICE(CONTD)A)Meter-dose Inhalers:A)Meter-dose Inhalers:

In the recent days doctors areIn the recent days doctors arerecommending mostly meter-doserecommending mostly meter-doseinhalers for asthma patients.inhalers for asthma patients.

This consists of:-This consists of:-A metal canister inside a plasticA metal canister inside a plastic

dispenser.Canister holds the spraydispenser.Canister holds the sprayand when pressed & released itand when pressed & released itdelivers required amount ofdelivers required amount ofmedications.medications.

One should use the device in a properOne should use the device in a propermanner to deliver the drug in amanner to deliver the drug in aproper way into the target.proper way into the target.

Medication is stored under pressure in the canister and released in

fixed volumes from the dosing chamber following actuation.


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DELIVERY DEVICE(CONTD)DELIVERY DEVICE(CONTD)

Spacers:Spacers:

These are useful for makingThese are useful for making

meter-dose inhaler (MDIs) formeter-dose inhaler (MDIs) for

easier & effective.A specier iseasier & effective.A specier is

a hollow chamber that fits intoa hollow chamber that fits intothe mouth-piece of the meterthe mouth-piece of the meter

dose inhaler.dose inhaler.

This device is useful to preventThis device is useful to prevent

any urgency.The drugany urgency.The drug

released stays for sometime inreleased stays for sometime inchamber then can bechamber then can be

breathed.breathed.

To maximize drug delivery, a spacer should be employed by all patients.

Infants and young children should use spacer with a facemask (as shown

above),low dead space, and a low resistance valve.

Courtesy of Richard Scarfone, MD, FAAP.eroChamber, (B) AeroChamber with mask, and (C) InspirEase.

e devices can facilitate the use of metered dose inhalers

decrease the amount of drug deposited on the upper airway.


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DELIVERY DEVICE(CONTD)DELIVERY DEVICE(CONTD)

B)Dry Powder Inhalers:B)Dry Powder Inhalers:This device instead of generatingThis device instead of generating

a pressurized spray,releases aa pressurized spray,releases afine,micronized powder asfine,micronized powder as

inhaled.inhaled.

In Dry powder is easier to useIn Dry powder is easier to usethan MDIs because,co-than MDIs because,co-ordination between breathingordination between breathingand device is not required inand device is not required in

dry powder inhalers(DPIs).dry powder inhalers(DPIs).

Available DPIs includes:-Available DPIs includes:-

Diskus,Flexhaler,Handinhaler,Diskus,Flexhaler,Handinhaler,

Diskhaler and Aerolizer.Diskhaler and Aerolizer.With these devices, the patient inhales the medication in the form of a fine powder

rather than an aerosol. (A) Aerolizer, (B) Flexhaler, (C) Diskus, (D) Diskhaler,

(E) HandiHaler. Courtesy of Dean Hess, RRT, PhD.


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DELIVERY DEVICE(CONTD)DELIVERY DEVICE(CONTD)Nebulizer:Nebulizer:It delivers a steady aerosol mist ofIt delivers a steady aerosol mist of

medicine through a face mask ormedicine through a face mask ormouth-piece,allowing to breathemouth-piece,allowing to breathenormally during an ongoing treatment.normally during an ongoing treatment.

This device consists of a chamberThis device consists of a chambercontaining drug(liquid) and compressorcontaining drug(liquid) and compressorpump.pump.

Traditionally operated nebulizers areTraditionally operated nebulizers arerecently replaced by ultra-sonicrecently replaced by ultra-sonicnebulizers,which are battery operatednebulizers,which are battery operated& expensive.& expensive.

Advantage:-Advantage:-

Plenty of medicines is delivered.Plenty of medicines is delivered.

Disadvantage:-Disadvantage:-

Lack of convenience(i.e. Difficult to carry).Lack of convenience(i.e. Difficult to carry).


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METERED DOSE INHALERMETERED DOSE INHALER

CANISTER AUTO TESTERCANISTER AUTO TESTERThe MDI Autotester system tests MDI aerosol canister forThe MDI Autotester system tests MDI aerosol canister for

drug delivery to the lungs using a shaker more alike withdrug delivery to the lungs using a shaker more alike withthat of human shaking motions than any systemthat of human shaking motions than any systemdeveloped previously.The system picks MDI canistersdeveloped previously.The system picks MDI canisters

from two racks and services two shaking arms usingfrom two racks and services two shaking arms usingpredefined shaking patterns(so keeping all testing thepredefined shaking patterns(so keeping all testing thesame & reducing the error found due to differentsame & reducing the error found due to differentoperators testing the canisters).Each canister isoperators testing the canisters).Each canister isweighed,fired & analysed multiple times to generateweighed,fired & analysed multiple times to generate

accurate data of how each canister performs over itsaccurate data of how each canister performs over itslifetime.Batch testing of the canister indicates thelifetime.Batch testing of the canister indicates theaccuracy of drug dispensing & variations betweenaccuracy of drug dispensing & variations betweenbatches & valves.batches & valves.


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PELLET SYSTEMPELLET SYSTEM

INVENTION:INVENTION:

The present invention resolves the problems previously outlined andThe present invention resolves the problems previously outlined and

provides a greatly improved parasiticidal pellet system which deliversprovides a greatly improved parasiticidal pellet system which deliversseparate doses of both immediate and long term control of parasiteseparate doses of both immediate and long term control of parasite

infestation in an animal as part of a single implant procedure wherein theinfestation in an animal as part of a single implant procedure wherein the

immediate dose is sufficient to kill pests already present in the animalimmediate dose is sufficient to kill pests already present in the animal

and the long term dose is sufficient to prevent reinfestation.and the long term dose is sufficient to prevent reinfestation.


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PELLET SYSTEM(CONTD)PELLET SYSTEM(CONTD)

OBJECTIVES AND ADVANTAGES OF THEOBJECTIVES AND ADVANTAGES OF THESYSTEM:SYSTEM:

i)Providing multicomponent parasiticidal pallet system.i)Providing multicomponent parasiticidal pallet system.

ii)Providing a pellet system for immediate as well as sustained deliveryii)Providing a pellet system for immediate as well as sustained delivery

of a parasiticide in order to kill doth internally and externally presentof a parasiticide in order to kill doth internally and externally presentwithin the animal which may reinfest the animal in future.within the animal which may reinfest the animal in future.

iii)Providing such a system and method which permits injection ofiii)Providing such a system and method which permits injection ofpredetermined doses of each of a parasiticide for immediate releasepredetermined doses of each of a parasiticide for immediate releaseand a parasiticide for extended release in a single injection.and a parasiticide for extended release in a single injection.

iv)Providing such a system and a method which permits subcutaneousiv)Providing such a system and a method which permits subcutaneousinjection of both an immediate release parasiticidal dose and aninjection of both an immediate release parasiticidal dose and anextended release parasiticidal dose.extended release parasiticidal dose.


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PELLET SYSTEM(CONTD)PELLET SYSTEM(CONTD)

v)Providing such a system and a method which permits anv)Providing such a system and a method which permits an

operator to selectively inject an extended releaseoperator to selectively inject an extended release

parasiticical dose into the needle.parasiticical dose into the needle.

vi)Providing such a system and method which permitsvi)Providing such a system and method which permits

serial injection of large no. of animals in single session.serial injection of large no. of animals in single session.

vii)Providing such a system and method which isvii)Providing such a system and method which is

simple,efficient and economical to manufacture,whichsimple,efficient and economical to manufacture,which

prevent reinfestation for a longer period (upto 150 days).prevent reinfestation for a longer period (upto 150 days).


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IMPLANTABLE METERED DOSEIMPLANTABLE METERED DOSE

DRUG DELIVERY DEVICESDRUG DELIVERY DEVICES

An implantable metered dose drug delivery system is disclosed whichAn implantable metered dose drug delivery system is disclosed whichcomprises implantable components including an injectioncomprises implantable components including an injectionsite,reservoir,metering valve and delivery catheter,all of which aresite,reservoir,metering valve and delivery catheter,all of which areinterconnected through suitable tubing.The metering valve has ainterconnected through suitable tubing.The metering valve has a

domed body constructed of a resilient elastomeric material with adomed body constructed of a resilient elastomeric material with afluid-flow passageway extending therethrough and opening into afluid-flow passageway extending therethrough and opening into achamber within the domed body.A valve is positioned within anchamber within the domed body.A valve is positioned within anoutlet leading from the chamber,which valve is opened by exertingoutlet leading from the chamber,which valve is opened by exertingan external pressure on the domed body to first collapse andan external pressure on the domed body to first collapse andocclude the fluid-flow passage way and the open the valve to permitocclude the fluid-flow passage way and the open the valve to permit

medication within the chamber to flow through the outlet.Whenmedication within the chamber to flow through the outlet.Whenexternal pressure is released,the fluid flow passway opens and theexternal pressure is released,the fluid flow passway opens and thereduced pressure in the chamber draws additional fluid through thereduced pressure in the chamber draws additional fluid through thepassageway to the chamber.passageway to the chamber.


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NECESSITY OF METERED DOSENECESSITY OF METERED DOSE

DRUG DELIVERY DEVICEDRUG DELIVERY DEVICE

Transporting drugs to specific and appropriate tissues of the body is not a trivialTransporting drugs to specific and appropriate tissues of the body is not a trivial

issue and can be more important than the benefits of the drug itself.issue and can be more important than the benefits of the drug itself.

Characteristics of the target tissues and of the drug-chemistry must beCharacteristics of the target tissues and of the drug-chemistry must be

considered before a treatment can be effective.considered before a treatment can be effective.

Delivery issues are largely linked with the drugs stability,mechanisms forDelivery issues are largely linked with the drugs stability,mechanisms formetabolism of each drug, the tolerance and reaction of the body to the drugmetabolism of each drug, the tolerance and reaction of the body to the drug

and the permeability of the target tissue.and the permeability of the target tissue.

Currently, drug delivery techniques focus on moving drugs past our bodysCurrently, drug delivery techniques focus on moving drugs past our bodys

barriers and into the blood stream,where it will be supplied to organs andbarriers and into the blood stream,where it will be supplied to organs and

tissues. This is done by ingestion,inhalation,absorption and injection.tissues. This is done by ingestion,inhalation,absorption and injection.

In the year 1990s Applied Physics Laboratory(APL) invented a type Of DDDIn the year 1990s Applied Physics Laboratory(APL) invented a type Of DDD

which can overcome the obstacles and cross the various barriers to supplywhich can overcome the obstacles and cross the various barriers to supply

drugs to various organs and tissues which were used to be obstructeddrugs to various organs and tissues which were used to be obstructed

earlier and thus proved to be an effective device.earlier and thus proved to be an effective device.


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CONCLUSIONCONCLUSION

This metered dose drug delivery devices proved toThis metered dose drug delivery devices proved tobe a boon the mankind and obviously to thebe a boon the mankind and obviously to therecent the medical science treatment.recent the medical science treatment.

The functions which were not done by the normalThe functions which were not done by the normaldug delivery devices the metered dose drugdug delivery devices the metered dose drugdelivery devices made the way,thus fading newdelivery devices made the way,thus fading newhorizon on the Bio-Medical field,and leading tohorizon on the Bio-Medical field,and leading toits development.its development.

The patients could find themselves more and moreThe patients could find themselves more and morerelaxed and less tension with the invention ofrelaxed and less tension with the invention ofthis metered dose drug delivery devices.this metered dose drug delivery devices.


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REFERENCEREFERENCE

www.google.comwww.google.com

www.labman.co.uk/Robot_MDIT.htmlwww.labman.co.uk/Robot_MDIT.html

www.acaai.orgwww.acaai.org/public//public/

www.nlm.nih.gov/medlineplus/healthtopics.htmlwww.nlm.nih.gov/medlineplus/healthtopics.html

http://www.arap.org/docs/MDI907_Final.pdfhttp://www.arap.org/docs/MDI907_Final.pdf..

www.clementclarke.comwww.clementclarke.com/...//.../index.htmlindex.html
http://www.google.com/http://www.google.com/http://www.labman.co.uk/Robot_MDIT.htmlhttp://www.labman.co.uk/Robot_MDIT.htmlhttp://www.acaai.org/public/http://www.acaai.org/public/http://www.acaai.org/public/http://www.acaai.org/public/http://www.nlm.nih.gov/medlineplus/healthtopics.htmlhttp://www.nlm.nih.gov/medlineplus/healthtopics.htmlhttp://www.arap.org/docs/MDI907_Final.pdfhttp://www.arap.org/docs/MDI907_Final.pdfhttp://www.arap.org/docs/MDI907_Final.pdfhttp://www.clementclarke.com/products/inspiratory_flow/in-check_dial/how_inhalers_work/index.htmlhttp://www.clementclarke.com/products/inspiratory_flow/in-check_dial/how_inhalers_work/index.htmlhttp://www.clementclarke.com/products/inspiratory_flow/in-check_dial/how_inhalers_work/index.htmlhttp://www.clementclarke.com/products/inspiratory_flow/in-check_dial/how_inhalers_work/index.htmlhttp://www.clementclarke.com/products/inspiratory_flow/in-check_dial/how_inhalers_work/index.htmlhttp://www.clementclarke.com/products/inspiratory_flow/in-check_dial/how_inhalers_work/index.htmlhttp://www.clementclarke.com/products/inspiratory_flow/in-check_dial/how_inhalers_work/index.htmlhttp://www.clementclarke.com/products/inspiratory_flow/in-check_dial/how_inhalers_work/index.htmlhttp://www.clementclarke.com/products/inspiratory_flow/in-check_dial/how_inhalers_work/index.htmlhttp://www.arap.org/docs/MDI907_Final.pdfhttp://www.nlm.nih.gov/medlineplus/healthtopics.htmlhttp://www.acaai.org/public/http://www.acaai.org/public/http://www.labman.co.uk/Robot_MDIT.htmlhttp://www.google.com/


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Moinak's Presentation_Meter Dose Drug Delivery Device.

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Transcript of Moinak's Presentation_Meter Dose Drug Delivery Device.