Metro North Regional Employment Board

12/11/2013

MA Biopharma Industry Employment

2003 2004 2005 2006 2007 2008 2009 2010 2011 2012

40,450 41,128

43,904

46,117

51,518

54,280 54,829 55,342 56,097 56,462

40%

10-yeargrowth rate

While employment growth has eased, the industry has added jobs in every year in the last decade. Employment in the industry has grown 12x faster than state and national growth rates for all employment.*

*3.2% MA 10-year employment growth, all industries

3.3% US 10-year employment growth, all industries

Source: U.S. Bureau of Labor Statistics, Quarterly Census of Employment and Wages (QCEW); MassBio

Biotechnology R&D Employment, 2012

Massachusetts has more employment classified as Biotechnology Research and Development than any other state.*

*NAICS 541711: Research and development in biotechnology

Source: U.S. Bureau of Labor Statistics, Quarterly Census of Employment and Wages (QCEW)

Massachusetts 27,883

California 23,438

Pennsylvania 10,810

New Jersey 8,962

Maryland 8,675

North Carolina 7,007

Texas 4,485

Washington 3,843

New York 3,796

Missouri 3,793

Biopharma Manufacturing Employment, 2012

Source: U.S. Bureau of Labor Statistics, Quarterly Census of Employment and Wages (QCEW)

Massachusetts is also a leading state in biopharma manufacturing, though well behind states with longer traditions in pharmaceutical manufacturing.*

*NAICS 3254:Pharmaceutical manufacturing

California 44,229

New Jersey 26,726

North Carolinia 20,946

New York 19,722

Pennsylvania 19,170

Illinois 17,755

Indiana 14,671

Texas 9,930

Massachusetts 8,960Michigan 7,940

Medical Device Employment, 2003-2012

Source: U.S. Bureau of Labor Statistics, Quarterly Census of Employment and Wages (QCEW)

2003 2012 % Change

California 73,488 74,377 1.2%

Minnesota 24,493 29,087 18.8%

Massachusetts 22,736 23,151 1.8%

Indiana 15,820 20,426 29.1%

New York 20,877 19,152 -8.3%

Pennsylvania 21,172 18,195 -14.1%

Texas 16,920 15,162 -10.4%

New Jersey 15,852 14,412 -9.1%

Illinois 13,808 14,411 -4.4%

Michigan 10,479 12,852 22.6%

Massachusetts remains third among states in employment in the medical device industry.

Massachusetts Pipeline by Therapeutic Area, 2013

Source: EvaluatePharma®, July 2013

All other9%

Blood3%

Endocrine4% Dermatology

2% Gastro-In-testinal

3%

Sensory Organs

4%

Cardio-vascular

4%

Muscu-loskeletal

5%

Central Nervous Sys-

tem 13%

Systemic Anti-infectives 16%

Oncology 37%

Therapeutic Area Candidates

Gastro-Urinary 20

Respiratory 21

Dermatology 26

Blood 35

Gastro-Intestinal 41

Endocrine 44

Cardiovascular 47

Sensory Organs 52

Musculoskeletal 58

Central Nervous System 156

Systemic Anti-infectives 186

Oncology 429

All Other 59

Total (R&D) 1174

Largest Industry Employers in MA, 2013

Genzyme, a Sanofi Company, has long been the largest employer in the industry in Massachusetts.

Since 2010, several companies have significantly increased in employment, including Novartis, PAREXEL, Shire and Millennium.

Sources: MassBio Membership Reports & Surveys; Boston Business Journal Book of Lists, 2013

1 Genzyme, a Sanofi Company 4,6002 Pfizer 2,6003 Biogen Idec 2,3004 Novartis 2,1005 PAREXEL International 2,0006 Covidien 1,8007 Hologic 1,7758 EMD Millipore 1,7569 Shire 1,50010 Thermo Fisher Scientific 1,450

Vertex 1,45012 Millennium: Takeda Oncology 1,20413 AstraZeneca 94814 Charles River Laboratories 93015 Abbott Laboratories 850

16 EMD Serono 70417 Nova Biomedical 70018 Cubist 63819 Sunovion Pharmaceuticals (DSP) 59320 Merck 50021 Bristol-Myers Squibb 40022 Lantheus 37523 Alkermes 32524 New England Biolabs 28025 Organogenesis 27426 Cell Signaling 270

Immunogen 27028 Ironwood 26029 Momenta Pharmaceuticals 24530 Eisai 237

Top occupations in selected counties

Manufacturing Production Technicians

Clinical Data Managers

Biological Technicians

Validation Engineers

Biostatisticians

Regulatory Affairs Specialists

Medical And Clinical Laboratory Technicians

Quality Control Analysts

Quality Control Systems Managers

Regulatory Affairs Managers

Medical And Clinical Laboratory Technologists

Clinical Research Coordinators

Biologists

Chemists

Medical Scientists, Except Epidemiologists

0 500 1,000 1,500 2,000

Suffolk, MAMiddlesex, MANorfolk, MAPlymouth, MA

Aug 01, 2012 –Jul 31, 2013

n=6,737

Employers with the most job openingsSuffolk, MAMiddlesex, MANorfolk, MAPlymouth, MA

Aug 01, 2012 –Jul 31, 2013

Amgen

Broad Institute

Ariad Pharmaceuticals Incorporated

Takeda Pharmaceuticals North America, Inc.

Astrazeneca

Shire Pharmaceuticals Group Plc

Cubist Pharmaceuticals

Millipore Corporation

Vertex Pharmaceuticals

Biogen Idec

Biogen Incorporated

Sterling Life Sciences

Pfizer

Novartis

Genzyme

0 50 100 150 200 250 300 350 400 450 500

n=6,737

Educational requirementsSuffolk, MAMiddlesex, MANorfolk, MAPlymouth, MA

Aug 01, 2012 –Jul 31, 2013

47%

46%

4% 3%

Bachelor's DegreeGraduate Or Professional DegreePost-Secondary Or As-sociate's DegreeHigh School

n=6,737

Technicians – Top detailed occupationsSuffolk, MAMiddlesex, MANorfolk, MAPlymouth, MA

Aug 01, 2012 –Jul 31, 2013

Manufacturing Engineers

Manufacturing Production Technicians

Biological Technicians

Medical And Clinical Laboratory Technicians

Medical And Clinical Laboratory Technologists

0 50 100 150 200 250 300 350 400

n=1,007

Technicians – Educational requirementsSuffolk, MAMiddlesex, MANorfolk, MAPlymouth, MA

Aug 01, 2012 –Jul 31, 2013

53%

17%

16%

15%

Bachelor's DegreeGraduate Or Professional DegreePost-Secondary Or As-sociate's DegreeHigh School

n=1,007

Technicians – Skills in demandSuffolk, MAMiddlesex, MANorfolk, MAPlymouth, MA

Aug 01, 2012 –Jul 31, 2013

Regulatory Affairs

Immunology

Data Management

Laboratory Equipment

Clinical Study

Good Laboratory Practices (GLP)

Manufacturing Processes

Biology

Experiments

Biotechnology

Clinical Trials

Validation

Chemistry

Good Clinical Practices (GPC)

Clinical Research

0 50 100 150 200 250 300

n=1,007

Technicians – Top employersSuffolk, MAMiddlesex, MANorfolk, MAPlymouth, MA

Aug 01, 2012 –Jul 31, 2013

Hallmark Health

Bristol-Myers Squibb

Flir Systems

Commonwealth Sciences, Inc

Charles River Laboratories International, Inc

Novartis

Pfizer

Quintiles

Shire Pharmaceuticals Group Plc

Life Technologies

Quest Diagnostics Incorporated

Parexel

Cubist Pharmaceuticals

Sterling Life Sciences

Genzyme

0 10 20 30 40 50 60 70

n=1,007

Anticipated hires in next 12 months

Source: Massachusetts Life Sciences Industry Entry Level Employment Demand Report 2013

Biotechnology competency worksheet