Memorandum of understanding between the … files/CAJAL/2019/WBI...-Feeding the human brain model....

CAJAL Neuroscience Training Course

Whole Brain Imaging Bordeaux, September 8-28, 2019

The CAJAL Advanced Neuroscience Training Programme www.cajal-training.org

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Keynote speakers

Jan BJAALIE, PhD (University of Oslo - Norway) Jan Bjaalie, M.D., Ph.D., is professor at the Institute of Basic Medical Sciences, University of Oslo, and Infrastructure Operations Director and leader of the Neuroinformatics Platform of the EU Human Brain Project. He was founding Executive Director of the International Neuroinformatics Coordinating Facility (INCF) and is currently head of the INCF Norwegian Node and member of the INCF Council for Training, Science, and Infrastructure. His research group has studied wiring patterns in the brain and developed data systems for organizing and managing heterogeneous neuroscience

research data by use of a new generation of digital brain atlases. The group develops software and workflows for analysis of data integrated in the atlases (“Google maps of the brain”). Jan Bjaalie is Chief editor of Frontiers in Neuroinformatics and Section editor of Brain Structure and Function. Talk : Tuesday 10th September 11:45 - “Sharing and integrating research data through the use of Human Brain Project brain atlasing services” Selected publications:

- Data integration through brain atlasing: Human Brain Project tools and strategies. Bjerke IE, Øvsthus M, Papp EA, Yates SC, Silvestri L, Fiorilli J, Pennartz CMA, Pavone FS, Puchades MA, Leergaard TB, Bjaalie JG. Eur Psychiatry. 2018 Apr;50:70-76.

- Brain-Wide Mapping of Axonal Connections: Workflow for Automated Detection and Spatial Analysis of Labeling in Microscopic Sections. Papp EA, Leergaard TB, Csucs G, Bjaalie JG Front Neuroinform. 2016 Apr 19;10:11.

- Feeding the human brain model. Tiesinga P, Bakker R, Hill S, Bjaalie JG. Curr Opin Neurobiol. 2015 Jun;32:107-14

- Addendum to “Waxholm Space atlas of the Sprague Dawley rat brain” [NeuroImage 97 (2014) 374-386]. Papp EA, Leergaard TB, Calabrese E, Johnson GA, Bjaalie JG. Neuroimage. 2015 Jan 15;105:561-2.

http://www.cajal-training.org/




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Sven CICHON, PhD (University of Basel - Switzerland) Sven Cichon, born 1966 in Frankfurt/Main, Germany, studied Biology at the University of Bonn and graduated in 1995 with a doctorate on the identification of genetic variability in CNS-expressed receptor/transporter genes and their influence on neuropsychiatric disorders. He worked as a postdoctoral fellow at the University of Bonn and at Millennium Pharmaceuticals Inc. (USA), and as a research group leader at the Universities of Antwerp and Bonn. Since 2009, he is Head of the research group “Genomic Imaging” at the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich.

In 2012, he was appointed as Director and Chairman of the Division of Medical Genetics at the University Hospital Basel and Professor of Medical Genetics at the Department of Biomedicine, University of Basel. His research focuses on the identification of genes influencing complex brain disorders and the structural and functional variability of the human brain. Talk : Tuesday 24th September 9:00 - “Neuroimaging and omics” Selected publications:

- Caspers S, Röckner ME, Jockwitz C, Bittner N, Teumer A, Herms S, Hoffmann P, Nöthen MM, Moebus S, Amunts K, Cichon S, Mühleisen TW (2019) Pathway-specific genetic risk for Alzheimer’s disease differentiates regional patterns of cortical atrophy in older adults. Cerebral Cortex, doi: 10.1093/cercor/bhz127 (Epub ahead of print).

- Stahl EA, Breen G, Forstner AJ, McQuillin A, Ripke S, .....Cichon S, et al. (2019) Genome-wide association study identifies 30 loci associated with bipolar disorder. Nature Genetics 51:793-803.

- Bittner N, Jockwitz C, Mühleisen TW, Hoffstaedter F, Eickhoff SB, Moebus S, Bayen UJ, Cichon S, Zilles K, Amunts K, Caspers S. (2019) Combining lifestyle risks to disentangle brain structure and functional connectivity differences in older adults. Nature Communications 10:621.

- Brainstorm Consortium (2018) Analysis of shared heritability in common disorders of the brain. Science 360:6395.

- Sønderby IE, Gústafsson Ó, Doan NT, Hibar DP, Martin-Brevet S, …, Cichon S, et al. (2018) Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia. Molecular Psychiatry, doi: 10.1038 (Epub ahead of print).

- Muhleisen TW, Reinbold CS, Forstner AJ, Abramova LI, Alda M, … , Cichon S . (2017) Gene set enrichment analysis and expression pattern exploration implicate an involvement of neurodevelopmental processes in bipolar disorder. Journal of Affective Disorders 228:20-25.

- Schulz H, Ruppert AK, Herms S, Wolf C, Mirza-Schreiber N, … , Cichon S . (2017) Genome-wide mapping of genetic determinants influencing DNA methylation and gene expression in human hippocampus. Nature Communications 8:1511.

- Hou L, Heilbronner U, Degenhardt F, Adli M, Akiyama K, … , Cichon S , et al. (2016) Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study. Lancet 387:1085-1093.


https://www.ncbi.nlm.nih.gov/pubmed/31043756

https://www.ncbi.nlm.nih.gov/pubmed/31043756




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- Forstner AJ*, Hofmann A*, Maaser A, Sumer S, Khudayberdiev S, … , Cichon S , et al. (2015) Genomewide analysis implicates microRNAs and their target genes in the development of bipolar disorder. Translational Psychiatry 5:e678. *joint first authorship

- Muhleisen TW, Leber M, Schulze TG, Strohmaier J, Degenhardt F, … , Cichon S . (2014) Genome-wide association study reveals two new risk loci for bipolar disorder. Nature Communications 5:3339.

Fabrice CRIVELLO, PhD (University of Bordeaux - France)

Fabrice Crivello is research director at the Atomic Energy Commission (CEA). His works are at the interface between methodology in neuroimaging and research in cognitive neuroimaging and neuroepidemiology. Following university studies in signal and image processing, he joined the GIN in October 1993. Within the Frédéric Joliot hospital department in Orsay, he obtained a PhD in biological and medical engineering on the detection and localization of cerebral activations with PET. At the Cyceron center in Caen, he completed a post-doctoral internship in the context of the

“European Computerized Human Brain Database” program aiming at building a multi-scale and multi-modality cerebral imaging database. In December 1998, he was recruited as a research officer at the CEA and obtained his authorization to conduct research in March 2006. Since July 2011 he has been assigned to Bordeaux, where, he and the GIN, have joined the IMN in January 2016. His research is structured along two complementary axes. The first concerns the development, implementation and distribution of automated procedures dedicated to the extraction of structural cerebral phenotypes. The second concerns the study of these phenotypes in the context of the exploitation of large cerebral imaging cohorts in order to characterize cerebral anatomical asymmetries, their factors of variability and their genetic determinants, and map the maturation and aging of cerebral anatomy. Talk : Monday 16th September 9:00 - “Brain structural MRI” Selected publications:

- Tzourio-Mazoyer N, Maingault S, Panzieri J, Pepe A, Crivello F, Mazoyer B. Intracortical Myelination of Heschl’s Gyrus and the Planum Temporale Varies With Heschl’s Duplication Pattern and Rhyming Performance: An Investigation of 440 Healthy Volunteers. Cerebral Cortex. 2018;287.

- Maingault S, Tzourio-Mazoyer N, Mazoyer B, Crivello F. Regional correlations between cortical thickness and surface area asymmetries: A surface-based morphometry study of 250 adults. Neuropsychologia. 2016;93:350-364.

- Kong XZ, Mathias SR, Guadalupe T et al. Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium. Proc Natl Acad Sci U S A. 2018;115:E5154-E5163.


http://www.gin.cnrs.fr/en/current-research/axis1/




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- Crivello F, Tzourio-Mazoyer N, Tzourio C, Mazoyer B. Longitudinal Assessment of Global and Regional Rate of Grey Matter Atrophy in 1,172 Healthy Older Adults: Modulation by Sex and Age. PLoS ONE. 2014;9:e114478.

Stéphanie DEBETTE, PhD (University of Bordeaux – France)

Stéphanie Debette, MD PhD is Professor of Epidemiology at University of Bordeaux -INSERM Bordeaux Population Health research center where she directs a team on “vascular and neurological diseases: integrative and genetic epidemiology”, and a practicing Neurologist at the Department of Neurology of the University Hospital of Bordeaux. Prof. Debette has been leading multiple large genomic and epidemiological studies on stroke, dementia and magnetic resonance imaging (MRI) markers of brain aging. She is currently the Chair of the International Stroke Genetics Consortium (ISGC) and leads a

European Research Council starting grant on genome-wide predictors of early structural brain changes, also aiming to explore interactions with lifestyle factors in the i-Share cohort, the largest study on student health. She is PI on several large national and European grants (RHU SHIVA [PI] on covert MRI-defined small vessel disease funded by the national investment for the future plan, JPND BRIDGET [PI] on genomics and epigenomics of MRI-markers of brain aging). She has been awarded the Claude Pompidou Foundation prize for research on dementia and the scientific excellence award from the European Stroke Organization. Roundtable : Thursday 26th September 11:00 - “Brain imaging ethics”

Selected publications:

- Mishra A, Chauhan G, Violleau MH, Vojinovic D, Jian X, Bis JC, […], Van Duijn CM, Ikram MA, Schmidt H, Longstreth WT, Fornage M, Seshadri S, Joutel A, Tzourio C, Debette S. Association of variants in HTRA1 and NOTCH3 with MRI-defined extremes of cerebral small vessel disease in older subjects. Brain. 2019; 142:1009-1023.

- Debette S, Schilling S, Duperron MG, Larsson SC, Markus HS. Significance of Magnetic Resonance Imaging Markers of Vascular Brain Injury: A Systematic Review and Meta-analysis. JAMA Neurol. 2019;76:81-94

- Malik R, Chauhan G, Traylor M, Sargurupremraj M, […], Seshadri S, Fornage M, Markus HS, Howson JMM, Kamatani Y, Debette S*, Dichgans M* *co-corresponding authors. Multi-ancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nat Genet. 2018;50:524-537.

- Chauhan G, Arnold CR, […], Debette S. Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies. Lancet Neurol, 2016;15:695-707.

- Debette S, Kamatani Y, […], Lathrop M, Leys D, Amouyel P, and Dallongeville J. New insight into the pathogenesis of cervical artery dissection: A genome-wide association study. Nat Genet. 2015; 47(1):78-83.





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Gwenaëlle DOUAUD, PhD (Oxford University – United Kingdom)

After starting her undergrad studies in maths ("classes prepas" in Paris), and then moving to fundamental physics, Prof. Douaud went on to receive her PhD in Neuroscience from the University of Paris XI-Orsay in 2006. She then moved to the Oxford University FMRIB Centre, where she has been working ever since. Her body of work focuses on translational research from imaging methods to applied human neuroscience, such as brain maturation and ageing, and with a particular emphasis on neurodegenerative disorders (Alzheimer's disease, movement disorders and motor neuron disease). Her group

currently pursues two lines of research, first by investigating the basal ganglia in health and movement disorders using high resolution MRI at 7T, second by working on (very) large imaging datasets to identify - and make sense - of relevant clinical information (e.g., UK Biobank).

Roundtable : Wednesday 25th September 9:00 - “NI databasing, sharing and meta-analyzing” Selected publications:

- "Structural Variability in the Human Brain Reflects Fine-Grained Functional Architecture at the Population Level". Smith S. et al, (2019), Journal of Neuroscience, 39, 6136 - 6149

- "Genome-wide association studies of brain imaging phenotypes in UK Biobank" Elliott LT. et al, (2018), Nature, 562, 210 - 216

- "A common brain network links development, aging, and vulnerability to disease" Douaud G. et al, (2014), Proceedings of the National Academy of Sciences, 111, 17648 - 17653

- "Preventing Alzheimer’s disease-related gray matter atrophy by B-vitamin treatment" Douaud G. et al, (2013), Proceedings of the National Academy of Sciences, 110, 9523 - 9528

- "Brain Microstructure Reveals Early Abnormalities more than Two Years prior to Clinical Progression from Mild Cognitive Impairment to Alzheimer's Disease" Douaud G. et al, (2013), Journal of Neuroscience, 33, 2147 – 2155

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Tim DYRBY, PhD (University of Copenhagen - Denmark)

Tim Dyrby has a PhD from The Technical University of Denmark (DTU) with an engineering background. He is group leader of the Microstructure and Plasticity (MaP) group and also is leading the preclinical research at Danish Research Centre for MRI (DRCMR), Copenhagen University Hospital Hvidovre, Denmark. Since 2015 he has been double affiliated at both DRCMR and as associate professor at DTU compute. His research focus is non-invasively mapping of brain-network and microstructure of the plastic brain using MRI and its relation to brain physiology. He works with diffusion MRI to

optimise and design MRI sequences in combination with biophysical modelling to estimate





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microstructural geometries of brain connections i.e. especially axon diameter mapping. For validation he has established an ex vivo imaging framework to acquire high-quality dMRI using preclinical MRI and that can be combined with various 2D histological and 3D synchrotron imaging techniques. Functional readouts include fMRI and optogenetics. His overarching research is image technologies to improve patient diagnosis and therefore much of his research naturally is translated to human MRI applications. Talk : Friday 13th September 9:00 - “White matter architecture imaging” Selected publications:

- Innocenti, G. M., Caminiti, R., Rouiller, E. M., Knott, G., Dyrby, T. B., Descoteaux, M. & Thiran, J-P. Diversity of Cortico-descending Projections: Histological and Diffusion MRI Characterization in the Monkey. Cerebral Cortex. 2018.

- Alexander, D. C., Dyrby, T. B., Nilsson, M. & Zhang, H. Imaging brain microstructure with diffusion MRI: practicality and applications. N M R in Biomedicine. 2018

- Sickmann, H. M., Skoven, C., Bastlund, J. F., Dyrby, T. B., Plath, N., Kohlmeier, K. A. & Kristensen, M. P. Sleep patterning changes in a prenatal stress model of depression. Journal of Developmental Origins of Health and Disease. 9, 1, p. 102-111, 2018.

- Nielsen, J. S., Dyrby, T. B. & Lundell, H. Magnetic resonance temporal diffusion tensor spectroscopy of disordered anisotropic tissue. Scientific Reports. 8, 2930 2018

Kathinka EVERS, PhD (Uppsala University - Sweden)

Kathinka Evers is Professor of philosophy at the Centre for Research Ethics & Bioethics (CRB) at Uppsala University and Professor ad honoram at the Universidad Central de Chile. She has been Invited Professor on the Chair Condorcet at École Normale Supérieure, Paris (2002); at Collège de France, Paris (2006 -7); and at Centro de Investigaciones Filosoficas, Buenos Aires (2012). Since 2013, she leads the Human Brain Project's Ethics and Society Subproject and the Philosophy and Neuroethics research group. Her research focuses on philosophy of mind, neurophilosophy, bioethics and

neuroethics. She directs the teaching and research on neuroethics at Uppsala University, where she started the first courses in the subject. She is also interested in the social responsibility of science, and was between 1997 and 2002 Executive Director for the Standing Committee for Ethics and Responsibility in Science of ICSU (International Council for Science); and 2008-2014, Expert in Scientific Review Panels for the ERC on ‘The Human Mind and Its Complexity’. Since her first public lectures at the University of Oxford in 1990, she has lectured extensively at universities and research centres in Europe, the U.S., South America, Asia, and Australia.

Roundtable : Thursday 26th September 11:00 - “Brain imaging ethics”





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Selected publications: - Farisco M, Kotaleski JH and Evers K (2018) Large-scale Brain Simulation and Disorders of

Consciousness. Mapping Technical and Conceptual Issues. Front. Psychol (9) doi: 10.3389/fpsyg.2018.00585.

- Evers K. Giordano J (2017) The Utility- and Use–of Neurotechnology to Recover Consciousness: Technical and Neuroethical Considerations in Approaching the “Hard Question” of Neuroscience. Front. Hum. Neurosci. https://doi.org/10.3389/fnhum.2017.00564

- Evers K. (2016) Neurotechnological assessment of consciousness disorders: five ethical imperatives. Dialogues in Clinical Neuroscience;18(2): 155-162.

- Evers K. (2016) The contribution of neuroethics to international brain research initiatives. Nature Reviews Neuroscience. DOI 10.1038/nrn.2016.143

- Evers K. Sigman M. (2013). Possibilities and limits of mind reading: A Neurophilosophical perspective. Consciousness and Cognition (22) 887-897.

Jean-Michel FRANCONI, PhD (University of Bordeaux - France)

Jean-Michel Franconi is full professor (PREX2) of Physics at Bordeaux University,. He led the Centre de Résonance Magnétique des Systèmes Biologiques (UMR5536, CNRS/University of Bordeaux, www.rmsb.u-bordeaux.fr ) for 14 years.(2002-2016) . He has published more than 120 original peer-reviewed papers in NMR methodology and applications. His expertise is in sequence development and and ultra-lowfield NMR. In particular, he has developed innovative approaches for Dynamic Nuclear Prepolarsation. He has also worked 10 years as “ MR application scientist” for

Siemens company.

Talk : Wednesday 11th September 9:00 - “MR image formation” Selected publications:

- Audran G, Bosco L, Brémond P, Franconi JM, Koonjoo N, Marque SR, Massot P, Mellet P, Parzy E, Thiaudière E. Enzymatically Shifting Nitroxides for EPR Spectroscopy and Overhauser-Enhanced Magnetic Resonance Imaging. Angew Chem Int Ed Engl. 2015 Nov 2;54(45):13379-84.

- Massot P, Parzy E, Pourtau L, Mellet P, Madelin G, Marque S, Franconi JM, Thiaudiere E. In vivo high-resolution 3D overhauser-enhanced MRI in mice at 0.2 T. Contrast Media Mol Imaging. 2012 Jan-Feb ;7(1) :45-50.

- Cochet H, Montaudon M, Laurent F, Calmettes G, Franconi JM, Miraux S, Thiaudière E, Parzy E. In vivo MR angiography and velocity measurement in mice coronary arteries at 9.4 T: assessment of coronary flow velocity reserve. Radiology. 2010 Feb;254(2):441-8.

- Rivière L, Moreau P, Allmann S, Hahn M, Biran M, Plazolles N, Franconi JM, Boshart M, Bringaud F. Acetate produced in the mitochondrion is the essential precursor for lipid biosynthesis in procyclic trypanosomes. Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12694-9.


https://doi.org/10.3389/fnhum.2017.00564

http://www.rmsb.u-bordeaux.fr/




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- Berry I, Démonet JF, Warach S, Viallard G, Boulanouar K, Franconi JM, Marc-Vergnes JP, Edelman R, Manelfe C. Activation of association auditory cortex demonstrated with functional MRI. Neuroimage. 1995 Sep;2(3):215-9.

Gitte KNUDSEN, PhD (University of Copenhagen - Denmark)

Gitte Moos Knudsen, Professor of neurobiology, chief consultant, Chairman of the Neurobiology Research Unit at the Copenhagen University Hospital Rigshospitalet and Director of Center for Experimental Medicine Neuropharmacology (NeuroPharm). I am a translational neurobiologist and clinical neurologist with interest in advanced methodological developments that I subsequently apply in my research to address pertinent neurobiological and clinical issues. My scientific interests include blood-brain barrier transport, neurobiology of cerebral blood flow and

metabolism and the neurobiology of cerebral neurotransmission with particular emphasis on molecular brain imaging. The research focus of The Center for Experimental Medicine Neuropharmacology (NeuroPharm) is to answer pertinent and basic questions regarding human brain disease mechanisms and predict brain responses to categories of neuromodulatory interventions as well as treatment efficacy. For this purpose, we use PET brain scanning to image brain receptors and receptor occupancy, and fMRI to evaluate drug effects on the brain hemodynamic response as well as the brains regional interactions, i.e., functional connectivity. Published more than 351 Medline indexed scientific papers and reviews as well as 28 books/book chapters. Citations: >14.000, H-index: 60 (Google Scholar), 49 (ResearcherID). Talk : Monday 23rd September 9:00- “Brain PET” Selected publications:

- Haahr ME, Fisher PM, Jensen CG, Frokjaer VG, Mc Mahon B, Madsen K, Baaré WFC, Lehel S, Norremolle A, Rabiner EA, Knudsen GM. Central 5-HT4 receptor binding as biomarker of serotonergic tonus in humans: a [11C]SB207145 PET study. Mol Psychiatry. 2014 Apr;19(4):427-32

- Fisher PM, Madsen MK, Mc Mahon B, Holst KK, Andersen SB, Laursen HR, Hasholt LF, Siebner HR, Knudsen GM. Three-week bright-light intervention has dose-related effects on threat-related corticolimbic reactivity and functional coupling. Biol Psychiatry. 2014 Aug 15;76(4):332-9

- Mc Mahon B, Andersen SB, Madsen MK, Hjordt LV, Hageman I, Dam H, Svarer C, da Cunha-Bang S, Baaré W, Madsen J, Hasholt L, Holst K, Frokjaer VG, Knudsen GM. Seasonal difference in brain serotonin transporter binding predicts symptom severity in patients with seasonal affective disorder. Brain. 2016 May;139(Pt 5):1605-14

- Beliveau V, Ganz M, Feng L, Ozenne B, Højgaard L, Fisher PM, Svarer C, Greve DN, Knudsen GM. A High-Resolution In Vivo Atlas of the Human Brain's Serotonin System. J Neurosci. 2017 Jan 4;37(1):120-128





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- da Cunha-Bang S, Hjordt LV, Perfalk E, Beliveau V, Bock C, Lehel S, Thomsen C, Sestoft D, Svarer C, Knudsen GM. Serotonin 1B receptor binding is associated with trait anger and level of psychopathy in violent offenders. Biol Psychiatry. 2017 Aug 15;82(4):267-274

Russ POLDRACK, PhD (Stanford University - USA)

Russell Poldrack is the Albert Ray Lang Professor in the Department of Psychology at Stanford. His research uses brain imaging techniques to understand the brain systems that support decision making and self-control, and to investigate the dynamics of brain function over multiple time scales. He is also director of the Stanford Center for Reproducible Neuroscience, which is dedicated to developing tools to help improve the openness, transparency, and reproducibility of neuroscientific research.

Talk : Thursday 12th September 9:00 - “Task-related FMRI” Selected publications:

- Shine JM, Breakspear M, Bell P, Martens KE, Shine R, Koyejo O, Sporns O, Poldrack RA (2019). The low dimensional dynamic and integrative core of cognition in the human brain. Nature Neuroscience.

- Esteban O, Markiewicz C, Blair, RW Moodie C, Isik AI, Aliaga AE, Kent J, Goncalves M, DuPre E, Snyder M, Oya H, Ghosh S, Wright J, Durnez J, Poldrack RA, Gorgolewski KJ. (2018). FMRIPrep: a robust preprocessing pipeline for functional MRI. Nature Methods.

- Poldrack RA (2018). The New Mind Readers: What Neuroimaging Can and Cannot Reveal about our Thoughts. Princeton University Press.

- Shine JM, Auburn MJ, Breakspear M, Poldrack RA (2018). The modulation of neural gain facilitates a transition between functional segregation and integration in the brain.eLife, 2018;7:e31130

Urs RIBARY, PhD (Behavioral and Cognitive Neuroscience Institute - Canada)

Urs Ribary is the Endowed BC LEEF Leadership Chair in Cognitive Neuroscience, the Director of the Behavioral and Cognitive Neuroscience Institute (BCNI), and Professor in Psychology, Pediatrics and Psychiatry at Simon Fraser University and University of British Columbia in Vancouver since 2007. He was originally trained in neuroscience and neuropharmacology at the prestigious Swiss Federal Institute of Technology (ETH) in Zurich, Switzerland. For almost 20 years he was Professor in Neuroscience and Director of the functional Brain Imaging Center at NYU Medical Center in New

York City, USA. He is a world-renowned neuroscientist & pioneer in human brain imaging with expertise in functional brain network connectivity and communication dynamics in the





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healthy human brain, cognitive disabilities and patients with neurological and psychiatric symptoms. His work covers a multidisciplinary range, reflected by over 200 publications, over 100 invited talks and a total awared funding of ~180M$ (consolidated in CAD) as PI, Co-PI or Co-I. His work has been highlighted in Nature Neuroscience, Neuron, the New York Times (twice) and various TV channels including the Discovery Channel, 60-Minutes and resulted in a patent and a 50M US$ mandate from a single donor (as PI). Earlier, 3 of his papers (all published in PNAS) were among the 10 most cited publications in the field. His successful research career is continuously reflected in major discoveries and impacts relating to a better understanding of the underlying neurophysiological mechanisms and brain circuitry in health and disease, the development of neural biomarkers, and was further essential in the translation into interventional strategies, including cognitive training programs for dyslexia and neurosurgical DBS for minimal conscious patients. During his tenure as BC LEEF Chair in particular, he further published on expanded brain imaging dynamics in health and disease, reviews and novel conceptual overviews of current findings and their implications for how dynamic brain imaging technologies can be further used to probe structural, functional and temporal connectivity to better understand, diagnose and treat cognitive disabilities and neuro-psychiatric pathologies including the many forms of traumatic brain injury. In 2017, he also provided first evidence for a neurophysiological framework toward unified principles of cortical processing: "The Neural ATG-Switch". Talk : Wednesday 18th September 9:00 - “EEG-MEG connectivity dynamics” Selected publications:

- Localizing Event-Related Potentials Using Multi-source Minimum Variance Beamformers: A Validation Study. Herdman AT, Moiseev A, Ribary U. Brain Topogr. 2018 Jul;31(4):546-565.

- Minimum variance beamformer weights revisited. Moiseev A, Doesburg SM, Grunau RE, Ribary U. Neuroimage. 2015 Oct 15;120:201-13.

- Fast dynamics of cortical functional and effective connectivity during word reading. Bedo N, Ribary U, Ward LM. PLoS One. 2014 Feb 14;9(2):e88940.

- Spatial-temporal dynamics of cortical activity underlying reaching and grasping. Virji-Babul N, Moiseev A, Cheung T, Weeks D, Cheyne D, Ribary U. Hum Brain Mapp. 2010 Jan;31(1):160-71

Mickael TANTER, PhD (ESPCI - France)

Mickael Tanter is a research professor of the French National Institute for Health and Medical Research (INSERM) and distinguished professor of ESPCI Paris. He is heading the laboratory “Physics for Medicine” at ESPCI Paris, France. He is also the director of the first INSERM Technology Research Accelerator created in 2016 and dedicated to Biomedical Ultrasound. Mickael Tanter is a world-renowned expert in biomedical ultrasound and wave physics. He authored more than 300 peer-reviewed papers and book chapters (hIndex 61 from Isi Web of knowledge) and is the recipient of 50 international patents. He co-invented several major





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innovations in Biomedical Ultrasound: Transient Elastography, Ultrafast Ultrasound and Shear Wave Elastography for cancer and cardiovascular diagnosis, functional Ultrasound imaging of brain activity and Super-Resolution Ultrasound. M. Tanter is also the co-founder of several MedTech companies in Biomedical Ultrasound (Supersonic Imagine, CardiaWave, Iconeus). Talk : Wednesday 18th September 11:00 - “Functional ultrasound”

Selected publications: - - C. Errico, J. Pierre, S. Pezet, Y. Desailly, Z. Lenkei, O. Couture*, M. Tanter*. Ultrafast

ultrasound localization microscopy for deep in vivo super-resolution vascular imaging. Nature, September 2015

- - Demene C, Baranger J, Bernal M, Delanoe C, Auvin S, Biran V, Alison M, Mairesse J, Harribaud E, Pernot M, Tanter M* & Baud O*. Functional ultrasound imaging of brain activity in human newborns. Science Translational Medicine 201

- - M.E. Fernandez-Sanchez et al. Mechanical induction of the tumorigenic beta-catenin pathway by tumour growth pressure. Nature, July 2015

Arthur TOGA, PhD (Keck School of Medicine of USC - USA)

Arthur W. Toga, Ph.D., is Provost Professor of Ophthalmology, Neurology, Psychiatry and the Behavioral Sciences, Radiology and Biomedical Engineering, and Director of the USC Institute of Neuroimaging and Informatics. One of the world’s leading authorities on neuroimaging, informatics, mapping brain structure and function, and brain atlasing, Dr. Toga came to USC September 1, 2013, from UCLA, where he was Distinguished Professor of Neurology, David Geffen Chair in Informatics and University Professor. His interdisciplinary work led to the creation of the Laboratory of Neuro Imaging

(LONI), which is one of the most advanced multidisciplinary neurological research centers in the world serving numerous multisite neuroscience projects from around the world. Funded by National Institutes of Health (NIH) grants as well as industry partners, LONI houses one of the largest computing facilities and largest brain image repository in the world. He is an author or co-author of more than 750 peer-reviewed papers, 1000 abstracts and 80 book chapters or books, among them Brain Mapping: The Methods. He is the founding editor of the journal NeuroImage. Dr. Toga has received numerous awards for his research and teaching, including the Pioneer in Medicine Award, Smithsonian Award for Scientific Innovation and Giovanni DiChiro Award for Outstanding Scientific Research. He holds the Ghada Irani chair in Neuroscience and has been on the Thomson Reuters' Highly Cited Researchers for many years. Roundtable : Wednesday 25th September 9:00 - “NI databasing, sharing and meta-analyzing”





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Selected publications: - Duncan D, Vespa P, Pitkänen A, Braimah A, Lapinlampi N, & Toga AW 2019 Big data sharing

and analysis to advance research in post-traumatic epilepsy. Neurobiology of Disease,

123:127-36. PMID: 29864492 - Ning K, Chen B, Sun F, Hobel Z, Zhao L, Matloff W, Alzheimer's Disease Neuroimaging Initiative,

& Toga AW 2018 Classifying Alzheimer's disease with brain imaging and genetic data using

a neural network framework. Neurobiology of Aging, 68:151-8. PMID: 29784544. - Ashish N, Bhatt P, Toga AW 2016 Global Data Sharing in Alzheimer Disease Research.

Alzheimer Disease and Associated Disorders, 30(2):160-8. PMID: 26523713. - Toga AW, Neu SC, Bhatt P, Crawford KL, Ashish N 2016 The Global Alzheimer’s Association

Interactive Network. Alzheimers & Dementia, 12(1):49-54. PMID: 26318022 - Toga AW & Crawford KL 2015 The Alzheimer’s Disease Neuroimaging Initiative Informatics

Core: A Decade in Review. Alzheimer's & Dementia, 11(7):832-9. PMID: 26194316 PMCID: PMC4510464

Christophe TZOURIO, PhD (University of Bordeaux – France)

Christophe Tzourio, MD, PhD, has a dual training in clinical neurology and epidemiology. He is Professor of epidemiology at the University of Bordeaux and Director of the Bordeaux Population Health (BPH) Research Center, Inserm U1219 which includes 13 teams and more than 450 staff members.In 2005, Prof. Tzourio became director of a new INSERM Research Unit U708 in Paris. In September 2013, he was appointed Director of the Bordeaux Population Health research center (BPH) Inserm U1219 at the Bordeaux University, which includes 13 teams and over 440 staff

members. Prof. Tzourio has worked mainly in the field of epidemiology of brain diseases. He is a leading worldwide researcher in this area, and has been invited to give many keynote lectures in plenary sessions of international meetings and to write editorials in international journals. He has published >360 original papers which have been cited >29,000 times in international peer-reviewed journals such as the British Medical Journal, The Lancet, The New England Journal of Medicine, Nature, Archives of Internal Medicine, Annals of Neurology, and Circulation (Google Scholar H index = 93). Christophe Tzourio has extensive experience in the design, management, and scientific output of large population-based cohort studies. He has been closely involved in several population-based cohorts, including the 3C study (role: PI; 9,293 participants, 15 years follow-up) which aims at evaluating the importance of vascular factors in dementia. He has also participated as a key investigator in large-scale randomized controlled trials. He is the co-PI of the LEOPOLD trial, an ongoing blood pressure lowering trial aiming at reducing the burden of silent cerebral infarcts which has received funding from the French Ministry of Health (1.4 million €) and network member of a Leducq Transatlantic Network of Excellence and of a grant 'Investment for Future' in the theme 'Cloud computing and big data'.


https://www.ncbi.nlm.nih.gov/pubmed/?term=29864492



http://www.ncbi.nlm.nih.gov/pubmed/?term=26318022

http://www.ncbi.nlm.nih.gov/pubmed/?term=The+Alzheimer%E2%80%99s+Disease+Neuroimaging+Initiative+Informatics+Core%3A+A+Decade+in+Review






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Roundtable : Tuesday 24th September 11:45 - “Imaging markers for neuro-epidemiology”

Selected publications: - Tully PJ, Debette S, Tzourio C. The association between systolic blood pressure variability with

depression, cognitive decline and white matter hyperintensities: the 3C Dijon MRI study. Psychological Medicine. 2018;48(9):1444-1453.

- Duperron M-G, Tzourio C, Sargurupremraj M, et al. Burden of Dilated Perivascular Spaces, an Emerging Marker of Cerebral Small Vessel Disease, Is Highly Heritable. Stroke. 2018;49(2):282-287.

- Kaffashian S, Soumare A, Zhu Y-C, Mazoyer B, Debette S, Tzourio C. Long-Term Clinical Impact of Vascular Brain Lesions on Magnetic Resonance Imaging in Older Adults in the Population. Stroke. 2016;47(11):2865-2869.

- Stephan BC, Tzourio C, Auriacombe S, et al. Usefulness of data from magnetic resonance imaging to improve prediction of dementia: population based cohort study. BMJ. 2015;350:h2863.

- Zhu YC, Dufouil C, Soumare A, Mazoyer B, Chabriat H, Tzourio C. High Degree of Dilated Virchow-Robin Spaces on MRI is Associated with Increased Risk of Dementia. J Alzheimers Dis. 2010;22(2):663-672.

- Dufouil C, Chalmers J, Coskun O, et al. Effects of blood pressure lowering on cerebral white matter hyperintensities in patients with stroke: the PROGRESS (Perindopril Protection Against Recurrent Stroke Study) Magnetic Resonance Imaging Substudy. Circulation. 2005;112(11):1644-1650

Arno VILLRINGER, PhD (Max Planck Institute - Germany) Arno Villringer is a neurologist and neuroscientist. He studied medicine at University of Freiburg, trained in Neurology at University of Munich, was consultant neurologist (Charité) and later head of Dept. Neurology at Benjamin Franklin hospital, Charité University Hospital, Berlin. Since 2007 he is director at the Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, the Mindbrainbody Institute at Humboldt University Berlin and director of the Clinic for Cognitive Neurology at University Hospital, Leipzig. His research focuses on the physiology of brain–body interactions

(emotions, stress, touch), their role in the development of obesity and hypertension eventually leading to stroke and dementia. In order to address these issues he combines behavioral, cognitive, and metabolic studies in humans with multimodal functional and structural brain imaging. In order to perform brain imaging in naturalistic settings starting in 1992 and in a series of studies thereafter, his group developed and validated near-infrared spectroscopy (NIRS) as a mobile functional neuroimaging tool. Talk : Thursday 19th September 9:00 - “Infrared imaging”





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Selected publications: - Iemi L, Busch NA, Laudini A, Haegens S, Samaha J, Villringer A, Nikulin VV (2019). Multiple

mechanisms link prestimulus neural oscillations to sensory responses. Elife 12;8. pii: e43620. - Fazli S1, Mehnert J, Steinbrink J, Curio G, Villringer A, Müller KR, Blankertz B (2012). Enhanced

performance by a hybrid NIRS-EEG brain computer interface. Neuroimage 59:519-29 [405 citations].

- Obrig H, Neufang M, Wenzel R, Kohl M, Steinbrink J, Einhäupl K, Villringer A (2000). Spontaneous low frequency oscillations of cerebral hemodynamics and metabolism in human adults. Neuroimage. 12:623-39 [562 citations].

- Villringer A, Chance B (1997). Noninvasive optical spectroscopy and imaging of human brain function. Trends Neurosci. 20:435-42 [1584 citations].

- Villringer A, Planck J, Hock C, Schleinkofer L, Dirnagl U (1993). Near infrared spectroscopy (NIRS): a new tool to study hemodynamic changes during activation of brain function in human adults. Neurosci Lett. 154:101-4 [1017 citations].


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