Maturation of Erythrocytes

HEMATOPOIESIS Subdivisions

stem

cell

Myelopoiesis

PMN

Bas

Lym

Mon

Eos

Pla

RBC

Lymphopoiesis

Granulopoiesis

Monocytopoiesis

Erythropoiesis

Megakaryopoiesis

Thrombopoiesis

{

Erythropoiesis:

is the formation of red blood cells, i.e., the

developmental processes of the red blood cells.

occurs in the red bone marrow from the

descendants of the proerythroblast stem cell by the

processes of proliferation and differentiation

each hemocytoblast stem cell can give rise to as

many as 211 mature cells.

Proerythroblast is:

also called a pronormoblast

the earliest stem cell (derived from the hemocytoblast = pluripotent hemopoietic cell)

found in the red bone marrow which is committed to develop into a red blood cell.

The retculocyte is characterized by a bluish hue due to ribosomes remaining in its cytoplasm.

Reticulocyte Red Blood Cell

Polychromotatophilic Normoblasat Orthochromatophilic Normoblast and Reticulocyte

Hemopoietic Growth Factor is:

any of the various regulatory proteins and

local hormones which:

▪ target the hematopoietic stem cells in the red

bone marrow

▪ promote the growth, organization, and

maintenance of red bone marrow and blood cells.

Erythropoietin is:

also referred to as EPO.

a glycoprotein hormone which stimulates the

production of red blood cells by stem cells in the

red bone marrow.

produced mainly by the kidneys.

released in response to decreased levels of oxygen

detected in the blood in the kidney nephron.