Masterclass in molecular oncology29-31 January 2015 - Prague, Czech Republic

PRELIMINARY PROGRAMME

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Dear participant,

A warm welcome to all attending the “Masterclass in molecularoncology”.

We would like to inform you that as of 28 April 2014 the name of ourFoundation changed to EXCEMED – Excellence in Medical Education.The name change will not impact your registration status in this or anyother Foundation event.

This transition marks an exciting point in the evolution of the Foundation.We are proud to have provided world-class education to thousands ofhealthcare professionals over the past four decades - as a result, theFoundation has become synonymous with delivery excellence and high-impact CME.

As we further develop our scientific and geographical presence it isimportant to us that our name accurately reflects the independentnature of the education we provide; EXCEMED symbolises our enduringmission to support the best possible outcomes for patients through themedical education we offer. We take pride in our complete dedication tothe provision of CME - it is our sole focus and our passion.

We wish you an inspiring and successful learning experience here inPrague.

Yours sincerely,

EXCEMED

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Aim Precision medicine in oncology is an evolving landscape. In recent yearsnew insights have been gained into driver genomic alterationsresponsible for cancer progression. The identification of a growingnumber of molecular targets and the availability of specific targetedtherapies are fueling the clinical research and rapidly changing clinicalpractice. The aim of this masterclass in molecular oncology is todescribe the basic principles of cancer genomics, techniques inmolecular biology and translational research. This live educationalintensive course will provide insights into the new taxonomy of cancer,the molecular pathways relevant for therapy and the methodology inmolecular diagnosis of cancer.

Educational FormatThis highly interactive course is designed to deliver effective knowledgein molecular oncology. The aim is to make the expertise of recognizedkey opinion leaders available to the learners, providing them with theopportunity to clarify doubts and solve uncertainties in the field ofmolecular oncology. For this purpose, the educational format will bebased on a series of lessons, followed by direct interactions amongexperts and learners, during the curricular activities in the meetingrooms and outside.

Learning objectivesAfter attending this masterclass in molecular oncology learners will beable to:

• Define relevant molecular pathways in oncology

• Distinguish genome analysis methods

• Illustrate personalized treatment options for cancer patients

Target audienceMedical oncologists who want to improve their knowledge in molecularbiology platforms for targeted therapy and drug discovery.

AccreditationAn application has been made to the EACCME® for CME accreditation ofthis EXCEMED live educational course “Masterclass in molecularoncology” to be held on 29-31 January 2015 in Prague, Czech Republic.

An application has been made to the ESMO for CME accreditation.

EXCEMED adheres to the principles of the Good CME Practice Group(gCMEp).

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Register to EXCEMED website:www.oncology.excemed.org

follow us on

http://twitter.com/EXCEMED_Onco

EXCEMED_Onco

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Chairmen and coordinators of the steering committeeEric Van CutsemUniversity Hospitals Gasthuisberg / LeuvenLeuven, Belgium

Yosef YardenWeizmann Institute of ScienceDepartment of Biological RegulationRehovot, Israel

Scientific secretariatEXCEMED - Excellence in Medical EducationSalita di San Nicola da Tolentino, 1/b00187 Rome, ItalyProgramme Manager: Giovanna RossiT +39 06 420 413 252 - F +39 06 420 413 677E-mail: info@excemed.org

Specialist Medical Advisor: Cristina Raimondi

EXCEMED is a Swiss Foundation with headquarters in 14, Rue du Rhône, 1204 Geneva, Switzerland

Organising secretariatMeridiano Congress InternationalVia Sapri, 6 - 00185 Rome, ItalyCongress Coordinator: David H. SlangenT +39 06 88 595 250 - F +39 06 88595 234E-mail: d.slangen@meridiano.it

Share your opinion with usWe are always looking for ways to bring our educational activitiesto the next level and meet your needs as a healthcare practitioner.

You will be asked to answer a post-event online survey to find out ifthe experience met your educational expectations. Your views alsohelp us tailor future initiatives.

Thank you for taking the time to participate.

Faculty membersAhmad AwadaMedical Oncology ClinicJules Bordet InstituteBrussels, Belgium

Alberto BardelliUniveristy of TorinoSchool of MedicineTurin, Italy

Fortunato CiardielloDivision of Medical OncologyDepartment of Experimental and Clinical Medicine andSurgery F. Magrassi and A. LanzaraSecond University of NaplesNaples, Italy

Jordi RodonVall d'Hebron Institute of Oncology (VHIO)Barcelona, Spain

Rolf StahelUniversity Hospital ZürichZürich, Switzerland

Charles SwantonLondon Research InstituteLondon, UK

Josep TaberneroVall d’Hebron University HospitalVall d'Hebron Institute of Oncology (VHIO)Barcelona, Spain

Eric Van CutsemUniversity Hospitals Gasthuisberg/LeuvenLeuven, Belgium

Yosef YardenWeizmann Institute of ScienceDepartment of Biological RegulationRehovot, Israel

Christoph C. ZielinskiComprehensive Cancer Center, ViennaGeneral Hospital and Medical University of Vienna Vienna, AustriaCentral European Cooperative Oncology Group (CECOG)

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Scientificprogramme

Scientific programme

Thursday, 29 January 2015

18.00 Welcome and presentation of the Masterclass courseE. Van Cutsem (Belgium) - Y. Yarden (Israel)

18.15 Opening keynote lecture: Spatial and Temporal Dynamics of Cancer EvolutionC. Swanton (UK)

19.00 Get together dinner

End of the first day

Evening sessionSession I

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Friday, 30 January 2015

07.30 Genome analysis methods (basics)Y. Yarden (Israel)

09.00 Basics of signal transduction (terminology and specific examples)A. Bardelli (Italy)

09.30 Signal transduction pathways I: the HER familyC. Zielinski (Austria)

10.00 Signal transduction pathways II: mTOR-PI3KJ. Rodon (Spain)

10.30 Signal transduction pathways III: RAS-RAF-MEKF. Ciardiello (Italy)

11.00 Coffee break

11.30 Genome analysis methods (advanced)Y. Yarden (Israel)

12.00 Biomarkers based on proteomics and high-resolutiongenomics/transcriptomicsSpeaker to be announced

12.30 Extended lunch break Poster viewing and oral poster presentations

Optional early bird sessionSession II

Session III

Scientific programme

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14.30 Controversies and panel discussion I: Cancer stem cellsModerators:F. Ciardiello (Italy)Y. Yarden (Israel)

15.15 Controversies and panel discussion II: Tumor heterogeneity and relevance to acquiredresistance to targeted therapiesModerators: A. Bardelli (Italy) C. Swanton (UK) J. Tabernero (Spain)

16.00 Coffee break

16.30 Essential of pharmacology of the old and new drugsA. Awada (Belgium)

17.00 The next generation of molecular targeted therapiesR. Stahel (Switzerland)

17.30 End of the second day

19.30 Science-medicine tutorials (breakthough scientific publications will be presentedand discussed)Mentors:E. Van Cutsem (Belgium)Y. Yarden (Israel)

20.30 Dinner

Optional evening session: exercisesSession V

Session IV

Saturday, 31 January 2015

17.30 Liquid biopsy in oncologyJ. Tabernero (Spain)

09.00 Parallel sessions

Breaking news: breast cancerC. Zielinski (Austria)

Breaking news: colorectal cancerE. Van Cutsem (Belgium)

Breaking news: lung cancerR. Stahel (Switzerland)

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10.30 Coffee break

10.50 Key messages from the parallel sessions

11.35 Design of clinical trials in the era of targeted agents: theory and practiceF. Ciardiello (Italy)

12.25 Extended lunch break Poster viewing and oral poster presentations

14.25 Closing keynote lecture: Cancer immunology and immunotherapy: clinicalapplication in melanoma Speaker to be announced

15.10 Closing remarks and end of the Masterclass course

Optional early bird sessionSession VI

Parallel sessionsSession VII

Session VIII

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Call for abstracts

In the spirit of supporting the dissemination of diverse oncologicalresearch, the Steering Committee is pleased to invite the submission ofabstract proposals for oral and poster presentations.

Authors are requested to send their abstract via e-mail by 29 November2014 to the following address: giovanna.rossi@excemed.org

Topic choicesA. Signal transduction pathways in oncology

B. Precision medicine in breast, colorectal and lung cancer

Submission procedureAbstracts must be written in English and should not exceed 300 words.

Abstract format: Title, Authors, Affiliations, Main text includingbackground, aims, materials and methods, results and conclusions.

The abstract should be structured as follows:

Introduction: an informative and short background of the study

Aims: outlining the main hypothesis and objectives of the study

Material and Methods: indicating the number, nature and type of cohortsor material being studied, as well as the main procedures, assays, tests ortreatments performed for it

Results: showing the main results obtained, confirming or refuting theinitial hypothesis, supported by statistics if appropriate

Conclusions: stating the key learning points of the study

• Abbreviations can be used after defining them first. The abstract titleshould reflect the contents and should be no longer than 150 characters.

• List the authors with family name first, followed by initials. The name ofthe first author is also the presenting author. Use font size 12, TimesNew Roman font, and line spacing 1.5.

• Authors are requested to disclose any financial support received and/orany potential conflict of interest at the end of the abstract.

The Scientific Committee will review the submitted abstracts choosing thebest abstracts for oral or poster presentation. The selected abstracts willbe published in the abstract book to be distributed on-site to allparticipants.

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Young (less than 5 years of activity in primary profession) medicaloncologists whose abstract is selected for oral and poster presentationswill receive a grant for their registration fee. Young medical oncologistscoming from Eastern Europe (Albania, Armenia, Azerbaijan, Belarus,Bosnia and Herzegovina, Bulgaria, Croatia, the Czech Republic, Georgia,Hungary, Kosovo, Macedonia, Moldova, Montenegro, Poland, Romania,Russia, Serbia, Slovakia, Slovenia, and Ukraine) who submit an abstractmay also apply for a travel grant of € 500.

EXCEMED will reward the authors of the four abstracts selected for oralpresentation with a grant of € 1,000. The value of this award will be givenas a voucher to be spent on participating in CME (Continuing MedicalEducation) courses and congresses no later than December 2015 asdefined with the winner in agreement with EXCEMED.

Notification of accepted abstracts will be sent by the first week ofDecember 2014.

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General information

VenueThis live educational course will take place at the:Park Inn Hotel Prague Svobodova 1 128 00 Prague, Czech Republic Tel. +420 225 995 225

LanguageThe official language of this live educational course will be English.

Registration fee The registration fee is . . . . . . . . . . . . . . . . . . . . . . . . . . . . € 500.00.

The registration fee for ESMO members is . . . . . . . . . . . € 375.00.

This fee includes:- Scientific sessions- Educational materials- Coffee breaks and luncheons- Dinner on 29 January - Dinner on 30 January - Certificate of attendance

For any information on accommodation and registration fees pleasecontact:David H. Slangen c/o Meridiano Congress InternationalT +39 06 88 595 250 - F +39 06 88595 234E-mail: d.slangen@meridiano.it

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Take a look at the oncology sectionof the EXCEMED website

EXCEMED has made a strong commitment to medical education inoncology and is developing live events such as workshops, expertmeetings and preceptorships, online activities, and otherprogrammes that will focus on key issues in oncology and themultidisciplinary approaches to patient management.

Visit the oncology section:

www.oncology.excemed.organd register to access free e-learning activities and receive updateson new events and resources.

All EXCEMED programmes are organized solely to promote the exchange anddissemination of scientific and medical information. No forms of promotionalactivities are permitted. This programme is made possible thanks to educationalgrants received from: Arseus Medical, Besins Healthcare, Bristol-Myers Squibb,Celgene, Centre d’Esclerosi Multiple de Catalunya (Vall d’Hebron UniversityHospital), Centre Hépato-Biliaire (Hôpital Paul Brousse), Croissance Conseil, Cryo-Save, Datanalysis, Dos33, Esaote, Ferring, Fondazione Humanitas, Fundación IVI,GE Healthcare, GlaxoSmithKline Pharmaceuticals, IPSEN, Italfarmaco, Johnson &Johnson Medical, K.I.T.E., Karl Storz, Lumenis, Merck Serono Group, PregLem,Richard Wolf Endoscopie, Sanofi-Aventis, Stallergenes, Stopler, Teva Pharma,Toshiba Medical Systems, Université Catholique de Louvain (UCL), University ofCatania.

EXCEMED - Excellence in Medical EducationHeadquarters14, Rue du Rhône - 1204 Geneva, SwitzerlandRepresentative OfficeSalita di San Nicola da Tolentino 1/b - 00187 Rome, ItalyT +39 06 420413 1 - F +39 06 420413 677

Copyright © EXCEMED, 2014. All rights reserved.

Improving the patient's life through medical educationwww.excemed.org