Mass Vaccination Using a Microneedle PatchhttpAssets)/573A3F... · 2016-03-08 · Mass Vaccination...
Transcript of Mass Vaccination Using a Microneedle PatchhttpAssets)/573A3F... · 2016-03-08 · Mass Vaccination...
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Mass Vaccination Using
a Microneedle Patch
Sebastien Henry, MS, MBA
Laboratory of Mark Prausnitz, PhD
Georgia Institute of Technology
Atlanta, GA, USA
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Microneedle patch
Microneedle patches are designed to replace syringes/needles and vials
Conventional syringes and needles
Vaccine vial
Microneedles
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Microneedle patch next to standard
hypodermic needle and syringe
100 microneedles
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Intact skin serves as a barrier
Epidermis
Dermis
cross-section of skin
stratum corneum (barrier)
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Vaccines do not get absorbed
through intact skin
Epidermis * barrier (stratum corneum)
Dermis
Vaccine
Skin cross-section
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Skin abrasion
Slow / inefficient delivery
Bifurcated needle
Variable dosing
Vaccines must be delivered
past the skin’s barrier
Injection
Expert administration
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Microneedles deliver vaccine to the skin
using a simple patch
650 um
Green dye represents
location of vaccine
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Microneedles deliver vaccine to the skin
using a simple patch
Epidermis
Dermis
Microneedles penetrate only the upper layers of skin
Standard (hypodermic) needle goes much deeper
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Microneedles target cells of the immune
system present in skin
Epidermis
Dermis
Microneedles dissolve and release their vaccine
Microneedles target cells of the immune system (Langerhans, dendritic cells) present in skin
Vaccine
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Microneedles dissolve rapidly in skin
a
b
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Microneedles dissolve rapidly in skin
a
b c
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Storage Administration Protection
Manufacturing Distribution Disposal
- Fast
- High volume
- Low cost
Step 1: Prepare microneedle mold
Step 2: Cast vaccine formulation into mold cavities
Step 3: Cast matrix formulation onto mold surface
Step 4: Dry and remove microneedle patch
Mass vaccination needs
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Storage Administration Protection
Manufacturing Distribution Disposal
Sharps waste disposal 10 ten-dose vials
100 needles and syringes
Cold-chain storage
- Small patch size - No refrigeration
100 microneedle
patches
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Storage Administration Protection
Manufacturing Distribution Disposal
- Small patch size
- No refrigeration
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Storage Administration Protection
Manufacturing Distribution Disposal
Apply patch Press to skin
and leave on skin
Remove from skin Vaccination is complete
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Storage Administration Protection
Manufacturing Distribution Disposal
- Administration by healthcare workers (HCW)
- Administration by minimally-trained personnel
- Self-administration with HCW supervision
- Self-administration
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Snaplicator data
Storage Administration Protection
Manufacturing Distribution Disposal
- Microneedle insertion
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Storage Administration Protection
Manufacturing Distribution Disposal
Normally
vaccinated
Normally
unvaccinated
Projected increase in vaccination coverage by
19 percentage points
(from 46% to 65%)
Martin Meltzer
CDC
Paula Frew
Emory
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Storage Administration Protection
Manufacturing Distribution Disposal
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Storage Administration Protection
Manufacturing Distribution Disposal
- No sharps waste
- Small disposal volume
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Storage Administration Protection
Manufacturing Distribution Disposal
• Microneedle-based vaccination induces a strong
immune response
• Microneedle-based vaccination is similar or better
than syringe/needle injection
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Microneedle and IM vaccination provide
full protection against virus challenge
Storage Administration Protection
Manufacturing Distribution Disposal
Inf = not vaccinated
IM = syringe/needle vaccination
MN = Microneedle vaccination
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Anthrax Becton Dickinson
BCG Georgia Tech/CDC
Chikungunya virus Queensland
Cholera toxin Leiden
Diptheria toxoid Leiden, Osaka
Hepatitis B Apogee/Georgia Tech, Urumqi Gen. Hospital
Hepatitis C Georgia Tech/Karolinska
HPV Queensland
Influenza Leiden, Georgia Tech/Emory, Novartis, Osaka Nanopass/Antwerp, BD/Sanofi/academics
Japanese encephalitis Becton Dickinson
Malaria Osaka, Cork Measles Georgia Tech/CDC Polio (inactivated) Georgia Tech/CDC/WHO/Gates Rotavirus (inactivated) Georgia Tech/CDC Smallpox Cyto Pulse Sciences
Tetanus Osaka West Nile virus Queensland
Status of vaccination using microneedles
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Thank you