MANAGEMENT OF OBESITY - Baron, Robert … · SUCCESSFUL WEIGHT LOSS MAINTENANCE 3000 subjects in...
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MANAGEMENT OF OBESITY: A SYSTEMATIC APPROACH
Robert B. Baron MD MS
Professor of Medicine
Associate Dean for GME and CME
Director, UCSF Weight Management Program
Declaration of full disclosure: No conflict of interest
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Flegal JAMA 2010
Prevalence of Obesity (Adults)
Obesity: 33.8%
Men: 32.2% Women: 35.5%
Overweight + obesity: 68%
Men: 72.3% Women: 64.1%
Severe Obesity: 6%
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.
Men and Women Aged 40 to 59 Years in 1999-2000 and 2007-2008
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Flegal JAMA 2010
Prevalence of Obesity (Children)
Severe obesity (97 percentile): 11.9%
Obesity (95 percentile): 16.9%
Overweight (85 percentile): 31%
No increase from 1999 to 2008
(except severe obesity in boys)
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Copyright © 2012 American Medical
Association. All rights reserved.
Prevalence of Obesity and Trends in Body Mass Index
Among US Children and Adolescents, 1999-2010
JAMA. 2012;307(5):483-490
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Flegal JAMA 2010
Obesity Disparities
Women, 40-59
Black: 52%, Hispanic: 47%, Whites: 36%
Teens
Black: 29%, Hispanic: 17.5%, Whites: 14.5%
Mental illness
Overweight + obese: 83%
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Obesity Trends* Among U.S. Adults
BRFSS, 2010 (*BMI ≥30, or ~ 30 lbs. overweight for 5’ 4” person)
No Data <10% 10%–14% 15%–19% 20%–24% 25%–29% ≥30%
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For a 40 yo woman, with normal
BP, lipids, and FBS which BMI is
associated with the lowest all-
cause mortality?
A. 18
B. 24
C. 28
D. 34
E. 38
18 24
28 34 38
0%
50%
0%0%
50%
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CLASSIFICATION OF OVERWEIGHT
AND OBESITY BY BMI
Obesity Class BMI (kg/m2)
Underweight <18.5
Normal 18.5 – 24.9
Overweight 25.0 – 29.9
Obesity I 30.0 – 34.9
II 35.0 – 39.9
Extreme Obesity III >40
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Flegal, JAMA, 2005
BMI AND MORTALITY:
Overall
Combined NHANES I, II, and III data set
BMI 25-59 y 60-69 y ≥70 y
<18.5 1.38 2.30 1.69
18.5-<25 1.00 1.00 1.00
25 to <30 0.83 0.95 0.91
30 to <35 1.20 1.13 1.03
≥35 1.83 1.63 1.17
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Flegal, JAMA, 2013
MORTALITY AND OBESITY
Meta-analysis of 97 studies of 2.8M people, 270,000 deaths
BMI HR
Below 25 (Normal) 1.0
25-30 (Overweight) 0.94
Above 30 (Obese) 1.18
***
30-35 (Grade 1 Obesity) 0.95
Above 35 (Grade 2/3 Obesity) 1.29
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For a 40 yo woman, with normal
BP, lipids, and FBS which BMI is
associated with the lowest all-
cause mortality?
1. 18
2. 24
3. 28
4. 34
5. 38
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Epidemic of Inactivity
60% US adults don’t
exercise regularly
25% are sedentary
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Shaw, Cochrane, 2006
EXERCISE FOR OBESITY Meta-analysis of 43 RCTs: 3476 participants
• Exercise plus diet vs diet alone
– -1.1 kg
• Increased intensity of exercise
– -1.5 kg
• Exercise without weight loss
– Reduced: BP, triglycerides, blood sugar
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Wei, JAMA 1999
FITNESS AND MORTALITY
Aerobics Center Longitudinal Study
CV death (RR) normal overweight obese Fit 1.0 1.5 1.6 Not fit 3.1 4.5 5.0
Total death (RR) normal overweight obese Fit 1.0 1.1 1.1 Not fit 2.2 2.5 3.1
25,714 men, 44 years old, 14 year observational study
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0
0.5
1
1.5
2
2.5
Relative Risk* of Death According to
Body Mass and Physical Activity
Body mass index (BMI)
25 – 29.9 < 25 > 30
> 3.5 hours/week
1 – 3.4 hours/week
< 1 hour/week
Physical activity level
* RR’s adjusted for age, smoking status, family history, menopausal status, hormone use, and other factors
** Reference group = women with 3.5 or > hours/week of physical activity and BMI of 25 or less
Hu FB, et al. N Engl J Med 2004;351:2694
2.42
1.91
1.64
1.33 1.28
1.55
1.18
1.00 **
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Estimating Calorie Needs
To estimate calories for weight maintenance:
If you are moderately active, multiply current
weight (pounds) x 15.
To estimate calories for weight loss:
Subtract 500 calories to lose approximately 1.0
pound per week
A pound of fat is about 3500 kcals
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Dansinger, JAMA 2005
COMPARISON OF ATKINS, ORNISH,
WEIGHT WATCHERS, AND ZONE
Intention to treat at 1 year Atkins Ornish WW Zone Wt Loss (kg) 2.1 3.3 3.0 3.2 Completers (%) 53 50 65 65
Completers at 1 year Atkins Ornish WW Zone Wt Loss (kg) 3.9 6.6 4.6 4.9
160 patients, randomly assigned
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Dansinger, JAMA, 2005
COMPARISON OF ATKINS, ORNISH,
WEIGHT WATCHERS, AND ZONE
Weight loss associated with adherence, but not diet type
Each group: 25% lost 5%, 10% lost 10% of initial weight
Each diet reduced LDL/HDL by 10%
No significant effects on BP or glucose
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Sacks, NEJM, 2009
COMPARISON OF WEIGHT LOSS DIETS
WITH DIFFERENT MACRONUTRIENTS
RCT of 811 patients, 4 diets: fat/protein/carbs
20/15/65; 20/25/55; 40/15/45; 40/25/35
6 months: 6kg, 7% weight; at 2 years: completers lost 4kg; 15% lost 10% of weight
Results similar for:
15% pro v. 25% pro
20% fat v. 40% fat
35% carbs v. 65% carbs
Attendance highly correlated with weight loss; satiety, hunger, lipids, insulin all equal
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Heterogeneity of Response to Weight Loss
Diets: Insulin Resistance
Insulin sensitive: low carb and high carb both effective for weight loss
Insulin resistant: low carb more effective
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Tsai and Wadden, Obesity, 2006
Very Low Calorie Diets (VLCD) vs Low
Calorie Diets (LCD): Meta-analysis of 6 RCTs
• Trials with direct comparisons
• Short-term: mean 12.7 weeks
• Long-term: mean 1.9 years
Weight loss (as % of initial weight):
short-term long-term
LCDs 9.7 5.0
VLCDs 16.1 6.3
(p) (0.001) (0.2)
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WEIGHT LOSS DIET BOTTOM LINE
• The type of diet does not really matter for weight loss.
• Sticking to the diet does matter
• Calories “trump” macronutrients
• But, select healthy, nutrient rich foods
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Weight Loss Diet Tips
• Ready to lose weight?
• Set realistic expectations.
• Choose diet that is easy to follow and
compatible with lifestyle.
• Control portion size (plate method, etc).
• Vegetables, fruit and whole grains
• Maintaining the weight you lose is key.
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BEHAVIORAL ASPECTS OF
WEIGHT LOSS
Goal setting
Self-monitoring
Stimulus control
Cognitive skills
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40 yo woman, BMI 36. Much to
your surprise (and satisfaction),
she has lost 35 pounds. In order to
maintain her new weight, her
lifelong daily calorie intake should
be: A. 2000 kcals
B. 1800 kcals
C. 1600 kcals
D. 1400 kcals
E. 1200 kcals
2000 kcals
1800 kcals
1600 kcals
1400 kcals
1200 kcals
0% 0% 0%0%0%
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Wing, Am J Clin Nutr, 2005
SUCCESSFUL WEIGHT LOSS
MAINTENANCE
3000 subjects in National Weight Control Registry: 30-lb weight loss for 1-year
Average weight loss 33 kg (10 BMI units less), average weight maintenance 5.5 years
45 years old, 80% women, 97% Caucasian
46% overweight as child, 46% one parent obese, 27% both parents
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SUCCESSFUL WEIGHT LOSS
MAINTENANCE
• High levels of physical activity
• Women 2545 kcal/week, men 3293 kcal/week
• (1-hour moderate intensity per day
• Only 9% report no physical activity
• Diet low in calories • 1381 kcal day
• 4.87 meals or snacks/day
• Fast food 0.74/week
• Regular self-monitoring of weight • 44% weigh once per day; 31% once per week
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40 yo woman, BMI 36. Much to
your surprise, she has lost 35
pounds. In order to maintain her
new weight, her lifelong daily
calorie intake should be:
1. 2000 kcals
2 1800 kcals
3 1600 kcals
4. 1400 kcals
5. 1200 kcals
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In the last year, I have prescribed
a medication for weight loss.
A. Yes
B. No
YesNo
0%0%
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The medication I most commonly
prescribe for weight loss is:
A. Phentermine
B. Orlistat (Xenical™, Alli™)
C. 3. Buproprion (Wellbutrin™)
D. 4. Exenatide (Byetta™,
Bydureon™)
E. 5. Phentermine/topiramate
(Qsymia™)
F. 6. Other
Phenterm
ine
Orlista
t (Xenica
l™, A
lli™)
3. Bupro
prion (W
ellbutr.
..
4. Exe
natide (B
yetta
™, B...
5. Phente
rmin
e/topira
ma..
6. Oth
er
0% 0% 0%0%0%0%
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The Neuroendocrinology of Energy Balance
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“LONG TERM” PHARMACOTHERAPY OF
OBESITY Review of all RCT’s more than 36 weeks published since 1960
Weight loss in excess of placebo:
% of initial kg’s
Phen-fen 11.0% 9.6 kg
Phentermine 8.1% 7.9 kg
Sibutramine 5.0% 4.3 kg
Orlistat 3.4% 3.4 kg
Dexfenfluramine 3.0% 2.5 Kg
Fluoxetine -0.4% -0.4 kg
Diethyproprion -1.5% -1.5 kg
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James, NEJM 2010
SIBUTRAMINE AND CARDIOVASCULAR
OUTCOMES (SCOUT)
9804 patients, over 55, with CV disease or diabetes
Sibutramine vs. placebo, 3.4 year f/u
Outcomes MI, stroke, cardiac arrest, CV death
Results Weight: -1.7 kg
BP: 1.2 vs 1.4 mm Hg
Combined outcome: 11.4% vs. 10.0% (HR 1.16, p = 0.02)
Nonfatal MI: 4.1% vs. 3.1% (HR 1.28; p = 0.02)
Nonfatal Stroke: 2.6% vs 1.9% (HR 1.36; p = 0.03)
Death: No differences
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LORCASERIN
Selective serotonin 2C receptor agonist
RCT of 3,182 adults, 52 week study
45% vs. 55% drop-out (lorcaserin vs. placeb)
5.8±0.2 kg vs. 2.2±0.1 kg wt. loss
Frequent adverse events: headache,
dizziness, and nausea
No increase in valvulopathy
Smith, NEJM, 2010
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Weight Loss Medications: October, 2010
• Sibutramine (Meridia™): withdrawn by Abbott • Increased risk of stroke and MI
• Lorcaserin (selective serotonin receptor agonist, more specific than fenfluramine): not approved by FDA • Animals with increased mammary adenocarcinoma
• Phentermine/topiramate (Qnexa™): not approved by FDA • Psychiatric adverse events: sleep, anxiety depression:
21% vs 10% with placebo
• Increased heart rate
• Teratogenicity
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Lorcaserin Update: May-June 2012
• FDA panel approved after new round of studies
• Industry sponsored study: 604 patients with type 2 diabetes
• After 1 year, 3.1% more weight loss (criteria >5%)
• 38% lost >5% weight vs. 16% on placebo
• Lingering uncertainty re breast tumors, valvular heart disease, psychiatric issues
• Approved June 2012. Trade name Belviq™
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Lorcaserin Update (Belviq™):
June 2013
• Classified as Schedule IV controlled substance
• Available as of June 7, 2013
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Phentermine/Topiramate Update:
February-July 2012
• FDA panel approved 20:2
• Industry sponsored study: 4323 subjects
• 9.3% weight loss
• Increased heart rate, increased cleft lip
• Recommend post-market monitoring for CV risk and recommendation against use in pregnancy
• Company plans larger trial (16,000 subjects)
• Approved July 2012. Trade name Qsymia™
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Phentermine/Topiramate (Qsymia™) Side
Effects
• Paraesthesia, dizziness, dysgeusia, insomnia, constipation, dry mouth
• Fetal harm: cleft lip, cleft palate
• Mood disorders: anxiety and depression
• Suicidal thoughts or behavior
• Acute angle glaucoma
• Cognitive dysfunction: concentration memory, language
• Metabolic acidosis and renal failure
• Hypoglycemia (in association with diabeyes meds)
• Interactions with alcohol and sedatives
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Prescribing Phentermine/Topiramate
(Qysmia™)
• Two prescriptions:
• 14 days on 3.75/23 and
• 30 days on 7.5/46
• Need DEA #
• Fax to certified pharmacy
• Pharmacy will call patient
• Drug delivered to patient’s home
• Local pharmacy availability soon
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OTHER INVESTIGATIONAL DRUGS
• Buproprion/naltrexone (Contrave™): Approved by FDA panel 12/10; rejected by FDA 2/11 (concern re heart attacks and CV risk.)
• Buproprion/zonisamide (Empatic™): Phase 3
• Exenatide (Byetta™), Liraglutide (Victoza™: Phase 2/3
• Pramlintide/metreleptin: Phase 2/3
• Cetilistat: Phase 3 in Japan
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PRINCIPLES OF DRUG THERAPY
• NIH: BMI > 30 kg/m2 or 27 kg/m2 with co-morbidity (but in practice almost never)
• Motivated to begin structured exercise and low calorie diet
• Begin medications at completion of one month successful diet and exercise
• Continue medications only if additional weight loss achieved in first month with meds
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Wouldn’t It Be Easier Just To Have
Surgery ?
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Definition BMI
Normal < 25
Overweight 25-29.9
Obese, class 1 30-34.9
Obese, class 2 35-39.9
Obese, class 3 40+
“Superobese” 60+
SURGERY
with co-morbidity
INDICATIONS FOR BARIATRIC SURGERY
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Types of Surgery
Restrictive
• Horizontal Gastroplasties
• Vertical Banded Gastroplasty (VGB)
• Silastic Ring Vertical Gastroplasty (SRVG)
• Adjustable Gastric Banding
• Sleeve Gastrectomy
Malabsorptive
• Jejunoileal Bypass (JIB)
• Biliopancreatic Diversion (BPD)
• Duodenal Switch
• Long Limb Gastric Bypass
Restrictive with Malabsorptive Component
• Roux-en-Y Gastric Bypass (RYGPB)
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Restrictive and Mixed
Procedures
VBG Adjustable Gastric Banding Roux-en-Y GB
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Sleeve
Gastrectomy
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Years
Bariatric Surgery: Weight Change
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LABS Consortium, NEJM, 2009
LONG-TERM OUTCOMES OF LAP BAND
• 151 patients, single center, 12 year f/u; 54.3% included
(82/151)
• Operative mortality: 0
• Mean weight loss: 20.75 kg (BMI decreased from 41.6 to
33.8)
• 60% of patients satisfied; overall quality of life unchanged
• 39% major complications; 60% required re-operation
Conclusion: Lap band results in poor long-term
outcomes
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Sleeve Gastrectomy Indications
Very high risk of co-morbidities
BMI >60
Possible non-compliance with meds (less risk of micronutrient deficiencies)
IBD, IBS, abdominal pain, SBO, adhesions, other GI morbidities
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Sjostrom, NEJM, 2007
Bariatric Surgery and Mortality Swedish Obese Subjects Study
4047 subjects, surgery vs. matched control. 10.9 years f/u
Max weight loss % Final weight loss %
Control 2
Gastric bypass 32 25
Vertical banded
Gastroplasty 25 16
Banding 20 14
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Resolution of Comorbidities
0
10
20
30
40
50
60
70
80
90
100
Diabetes Hyperlipidemia HTN Sleep apnea
Band
VBG
GBP
D Switch
% R
esolu
tion
Co
morb
idity
Bariatric Surgery – A Systematic Review and Meta-analysisBuchwald H. et al.
JAMA. 2004; 292(14):1724-37
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35 yo woman, BMI 42 in good health,
asks about bariatric surgery. Her
surgeon suggests a laporoscopic
roux-n-y. Her risk of mortality, DVT,
reintervention, or prolonged hospital
stay is: A. 1 in 200
B. 1 in 100
C. 1 in 50
D. 1 in 25
E. 1 in 10
1 in 2
00
1 in 1
00
1 in 5
0
1 in 2
5
1 in 1
0
0% 0% 0%0%0%
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LABS Consortium, NEJM, 2009
BARIATRIC SURGERY OUTCOMES
• Ten sites, 4776 patients. 3/4 roux-en-y (87% lap); 1/4 lap band
• 30 Day overall mortality: 0.3%
-lap band 0.0%
-roux-en-y (lap) 0.2%
-roux-en-y (open) 2.1%
• Composite (death, DVT, reintervention, 30 + days in hosp): 4.1%
-lap band 1.0%
-roux-en-y (lap) 4.8%
-roux-en-y (open) 7.8%
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35 yo woman, BMI 42 in good health,
asks about bariatric surgery. Her
surgeon suggests a laporoscopic
roux-n-y. Her risk of mortality, DVT,
reintervention, or prolonged hospital
stay is:
1. 1 in 200
2. 1 in 100
3. 1 in 50
4. 1 in 25
5. 1 in 10
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57 yo woman, BMI 42 with
diabetes, hypertension, and
creatinine 1.4 asks about bariatric
surgery. Her risk of mortality 30
days post-op is
A. 1 in 200
B. 1 in 100
C. 1 in 50
D. 1 in 25
E. 1 in 10
1 in 2
00
1 in 1
00
1 in 5
0
1 in 2
5
1 in 1
0
0% 0% 0%0%0%
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Mortality After Surgery Community Medicare Data: 55-64 year old
30 days 90 days 1 Year
2.0% 2.7% 5.2%
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Sjostrom, NEJM, 2007
Bariatric Surgery and Mortality Swedish Obese Subjects Study
Deaths HR Rate MI deaths Cancer deaths
Control 129 0.063 25 47
Surgery 101 0.76 0.050 13 29
(p = 0.04)
NNT 77 over 11 years (approx 850 per year)
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Benotti, Arch Surg, 2009
Weight Loss Before Bariatric Surgery
881 patients with gastric bypass; 6 month program to achieve
10% weight loss; 2/3 lost 5%; 1/2 lost 10%
Weight Change Complications %
Gain 5% 28.4
Gain 0-5% 27.9
Loss 0-5% 23.5
Loss 6-10% 14.2
Loss 10% 18.0
(p for trend = 0.004)
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Nutrition after Bariatric Surgery
Gastric Bypass Lap Band
Mulitvitamin 2 daily Mulitvitamin 1 daily
(400 mcg folate)
Omeprazole 20 mg daily Omeprazole 20 mg daily
Calcium (500mg TID) Calcium (500mg TID)
Vitamin D (200 IU TID) Vitamin D (500 IU TID)
Iron sulfate 325mg daily
(women)
Vitamin B12 500mcg SL daily
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BARON’S FACTS ABOUT OBESITY
Environmental changes work: YES
Diets work, but not for long in most people: YES, BUT THEY DO FOR SOME
Exercise improves health independent of weight change and aid in weight maintenance: YES
Continuation of conditions that promote weight loss promotes weight maintenance: YES
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BARON’S FACTS ABOUT OBESITY
For children, programs that involve parents and home promote greater weight loss: MAYBE
Provision of meals and meal replacement products promote greater weight loss: IN THE SHORT TERM
Medications can help achieve meaningful weight loss for as long as agents can be used: BUT WHAT ABOUT LONGER TERM CLINICAL OUTCOMES?
Surgery results in long term weight loss and reductions of diabetes and mortality: WITH COMPLICATIONS IN SOME/MANY AND A HIGH NNT Casazza, NEJM 2013
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GOALS OF MANAGEMENT
Be as fit as possible at current weight
Prevent further weight gain
If successful at 1 and 2, begin weight loss
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The Magic Formula