LIVER CANCER:Advances in Science and Clinical Management

MOUNT SINAI LIVER CANCER PROGRAM 14TH ANNIVERSARY

https://mssm.cloud-cme.com

FRIDAY, DECEMBER 13, 2019

1st NCI recognized Liver Cancer Program in the U.S.

Program Director

Josep M. Llovet, MD, PhDProfessor of MedicineCo-Director, Mount Sinai Liver Cancer Program

Sponsored byMount Sinai Liver Cancer Program

Hatch Auditorium Icahn School of Medicine at Mount Sinai

1468 Madison AvenueGuggenheim Pavilion 2nd FloorNew York, NY

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LocationIcahn School of Medicine at Mount Sinai Hatch Auditorium, Guggenheim Pavilion, 2nd Floor, 1468 Madison Avenue, New York, NY 10029

Directions and Parking: www.icahn.mssm.edu/about/visiting

Target Audience Hepatologists and Gastroenterologist, Oncologists, Surgeons, Radiologist, Pathologists and Basic Scientists interested in liver cancer from the New York Area and beyond.

Credit DesignationThe Icahn School of Medicine at Mount Sinai designates this live activity for a maximum of 7.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Activity Description This conference will assemble multidisciplinary experts on chronic liver diseases, hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) from the Mount Sinai Liver Cancer Program and two outstanding invited lecturers. The meeting is intended to provide a summary of the state-of the-art knowledge of the novel advancements reported in 2019 on the pathogenesis and clinical management of liver cancer, including the research conducted in Mount Sinai.

Activity Learning Objectives • Understand the epidemiology and disparities of liver cancer in the US.

• Review the current role of surgical and loco-regional treatments for liver cancer.

• Critical review of molecular therapies and SBRT in the management of advanced HCC.

• Understand the molecular rationale for immune therapies in HCC.

Registration FeeInternational Attendees $100 All Others ComplimentaryRegister Online at: https://mssm.cloud-cme.com

AccreditationThe Icahn School of Medicine at Mount Sinai is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Verification of AttendanceVerification of attendance will be provided to all professionals.

Special NeedsThe Icahn School of Medicine at Mount Sinai is in full compliance with provisions of the Americans with Disabilities Act (ADA) and is accessible for individuals with special needs. If you require special accommodations please contact the Page and William Black Post-Graduate School of Medicine at 212-731-7950.

AcknowledgmentThis activity is made possible in part by educational grants from:

BTGCelsion EisaiGlycotest

Conference Information https://mssm.cloud-cme.com

Office of CME at 212-731-7950 e-mail: cme@mssm.edu

LIVER CANCER:Advances in Science and Clinical Managment

PROGRAM

8:30 – 9:00am Registration

9:00 – 9:10am Welcome and Opening Ramon Parsons, MD, PhD

9:10 – 9:40am Achievements of Mount Sinai Liver Cancer Program 2005-19 Josep M. Llovet, MD, PhD

9:40 – 10:20am Hans Popper Lecture Introduction: Josep M. Llovet, MD, PhD

Precision Medicine and Combination Therapies in Advanced HCC R. Kate Kelley, MD

10:20 – 10:40am Coffee Break

10:40 – 11:50am PATHOGENESIS, EPIDEMIOLOGY AND DIAGNOSIS OF LIVER CANCER

Chairman: Scott Friedman, MD

10:40 – 11:10am From Fibrosis to Liver Cancer Scott Friedman, MD

11:10 – 11:30am Disparities in liver cancer in the US Nina Bickell, MD, MPH

11:30 – 11:50am Liquid Biopsy in the Management of Liver Cancer Augusto Villanueva, MD, PhD

11:50 – 12:30pm Lunch

12:30 – 1:50pm MANAGEMENT OF LIVER CANCER (EARLY-INTERMEDIATE STAGE)

Chairman: Myron Schwartz, MD

12:30 – 12:50pm Advances in the Surgical Treatment of HCC and iCCA Myron Schwartz, MD

12:50 – 1:10pm Multi-institutional Results of Liver Transplantation for HCC in the US

Parissa Tabrizian, MD, MSc

1:10 – 1:30pm Chemoembolization and Radioembolization in HCC Management

Edward Kim, MD

1:30 – 1:50pm Assessment of Radiological Response in Liver Cancer Sara Lewis, MD

1:50 – 2:10pm Coffee Break

FRIDAY, DECEMBER 13, 2019

MOUNT SINAI LIVER CANCER PROGRAM 14TH ANNIVERSARY

Complimentary Online Registrationhttps://mssm.cloud-cme.com

International Attendees $100

Conference Information https://mssm.cloud-cme.comOffice of CME at 212-731-7950 • e-mail: cme@mssm.edu

Cancellation Policy: All refund and cancellation requests must be emailed to the CME office at cme@mssm.edu by December 7, 2019.

Cancellations after this date are not eligible for a refund. An administrative fee of $50 will be deducted from your refund. No refunds will be issued for registration fees that are equal to or less than $50.

2:10 – 3:10pm MANAGEMENT OF LIVER CANCER (ADVANCED STAGE) Chairman: Josep M. Llovet, MD, PhD

2:10 – 2:40pm Molecular Targeted Therapies in Advanced HCC Josep M. Llovet, MD, PhD

2:40 – 3:10pm State-of-the-Art LectureRole of SBRT for the Treatment of HCC

Laura Dawson, MD, FRCPC

3:10 – 3:30pm Coffee Break

3:30 – 4:40pm NOVEL TARGETS AND BIOMARKERS FOR LIVER CANCER TREATMENT

Chairman: Samuel Waxman, MD

3:30 – 4:00pm Molecular Rationale for Neo-adjuvant Immunotherapy in HCC Miriam Merad, MD, PhD

4:00 – 4:20pm Biomarkers of Response to Immune Checkpoint Inhibitors in HCC Daniela Sia, PhD

4:20 – 4:40pm Novel Mouse Models of Hepatocellular Carcinoma Marina Ruiz de Galarreta, PhD

4:50pm Closing Remarks

MOUNT SINAI LIVER CANCER PROGRAM 14TH ANNIVERSARY

PROGRAM DIRECTOR JOSEP M. LLOVET, MD, PHD

Professor of Medicine, Division of Liver Diseases; Co-Director, Mount Sinai Liver Cancer Program

PROGRAM CHAIRS SCOTT L. FRIEDMAN, MD

Dean of Therapeutic Discovery, Professor of Medicine, Division of Liver Diseases; Co-Director, Mount Sinai Liver Cancer Program

MYRON E. SCHWARTZ, MD Professor of Surgery, Surgical Oncology; Mount Sinai Liver Cancer Program, Director of Liver Surgery, Recanati/Miller Transplantation Institute

SAMUEL WAXMAN, MD Distinguished Service Professor of Medicine, Hematology & Medical Oncology and Oncological Sciences

GUEST FACULTYLAURA DAWSON, MD, FRCPC

Professor of Radiation Oncology, University of Toronto

R. KATE KELLEY, MD Associate Professor of Clinical Medicine, Department of Medicine (Hematology/Oncology), University of California at San Francisco

HOST FACULTYNINA A. BICKELL, MD, MPH

Professor Population Health Science and Policy; Associate Director, Community Engaged and Equity Research, Cancer Prevention and Control, Tisch Cancer Institute

EDWARD KIM, MD Associate Professor of Radiology and Surgery; Mount Sinai Liver Cancer Program

SARA LEWIS, MD Assistant Professor of Radiology

MIRIAM MERAD, MD, PHD Professor of Oncological Sciences, Medicine, Hematology and Medical Oncology; Director, Precision Immunology Institute

MARINA RUIZ DE GALARRETA, PhD Fellow, Department of Oncological Sciences

DANIELA SIA, PhD Assistant Professor of Medicine, Liver Diseases; Mount Sinai Liver Cancer Program

PARISSA TABRIZIAN, MD, MSC Assistant Professor of Surgery; Recanati/Miller Transplantation Institute

AUGUSTO VILLANUEVA, MD, PhD Assistant Professor of Medicine, Divisions of Liver Diseases, Hematology and Medical Oncology; Mount Sinai Liver Cancer Program

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