organic solvent H2OH2O lipids everything else lipids everything else = = "nonhydrolyzable lipids"
LIPIDS 2. Where are they found in the cell? · LIPIDS hydrophobic or amphipathic small molecules 1....
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CE TAG LIPIDS hydrophobic or amphipathic small molecules 1. What are the main classes of lipids? 2. Where are they found in the cell? 3. Where did they come from? Lipids Classes Fatty acids • Free (toxic unless esterified) • Esterifed in glycerophospholipids, sphingolipids, glycerol lipids and sterol lipids monolayer PL, C lipid droplet mitochondrion cytoplasm cytosol ribosome Rough endoplasmic reticulum (ER) cell membrane peroxisome Golgi complex free ribosome smooth endoplasmic reticulum lysosome nucleus
Transcript of LIPIDS 2. Where are they found in the cell? · LIPIDS hydrophobic or amphipathic small molecules 1....
CE TAG
LIPIDS hydrophobic or amphipathic small molecules
1. What are the main classes of lipids? 2. Where are they found in the cell? 3. Where did they come from?
Lipids Classes
Fatty acids • Free (toxic unless esterified) • Esterifed in glycerophospholipids,
sphingolipids, glycerol lipids and sterol lipids
monolayer PL, C
lipid droplet
peroxisome
mitochondrion
cytoplasm cytosol
ribosome Rough endoplasmic reticulum (ER)
cell membrane
peroxisome
Golgi complex free ribosome
smooth endoplasmic
reticulum
lysosome
nucleus
CE TAG
LIPIDS hydrophobic or amphipathic small molecules
peroxisome
Lipids Classes
Fatty acids • Free (toxic unless esterified) • Esterifed in glycerophospholipids,
sphingolipids, glycerol lipids and sterol lipids
peroxisome
mitochondrion
cytoplasm cytosol
ribosome Rough endoplasmic reticulum (ER)
cell membrane
peroxisome
Golgi complex free ribosome
smooth endoplasmic
reticulum
lysosome
nucleus
1. What are the main classes of lipids? 2. Where are they found in the cell? 3. Where did they come from?
lipid droplet
In membranes
In cell membrane and lipid droplets
In lipid droplets
LIPIDS
peroxisome
CE GL
import Circulating Lipoprotein
• LDL from liver • Chylomicrons
from intestines
not to scale
Circulating FA (grey spacefill) imported from adipoctyes bound to protein: serum albumin; FA to mitochondria for oxidation/ATP prod.
not to scale
FA
IMPORT/EXPORT
C, GP
peroxisome
mitochondrion
cytoplasm cytosol
ribosome Rough endo. reticulum
cell membrane
peroxisome
Golgi complex free ribosome
smooth endoplasmic
reticulum
lysosome nucleus
1. What are the main classes of lipids ? 2. Where are they found in the cell? 3. Where did they come from? Import /Export and Synthesis/Trafficking
lipoprotein
FA Exported FA from fat cells (adipocyte)
bind to serum albumin for transport to tissue
CE GL
lipoprotein
Circulating Lipoprotein • VLDL exported from liver
(synthesized) lipids • Chylomicrons exported from
intestines (ingested lipids)
not to scale
lipoprotein
FA
lipid droplet
mitochondrion
cytoplasm cytosol
ribosome Rough endo.
reticulum
cell membrane
peroxisome
Golgi complex
smooth endoplasmic
reticulum
lysosome
lipid droplet
LIPIDS
1. What are the main classes of lipids? 2. Where are they found in the cell? 3. Where did they come from? Import and Synthesis/Trafficking
GP
GL
ST C
FA
PM
GP PM SP2
SP
GP1
GP1 Cardiolipin and phosphatidyl glycerol (2 lipids also found in bacteria, are made in the mitochondrion
ER (smooth) main site of lipid synthesis
SP2 Ceramide, a precursor of SP, is made in mitochondria.
C Golgi: sorts lipids
synthesized in cytoplasm Mostly in liver, mammary tissue
FA
elongation
elongation, desaturation
FA
FA
elongation
CE
ST
GP
PM
GL
C
