Lectures on respiratory physiology Diffusion. Swim bladder of a fish.
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Lectures on respiratory Lectures on respiratory physiology physiology Diffusion Diffusion
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Transcript of Lectures on respiratory physiology Diffusion. Swim bladder of a fish.
Lectures on respiratory physiologyLectures on respiratory physiology
DiffusionDiffusion
Swim bladder of a fish
Fick’s law of diffusion through a tissue sheet
Very thin blood-gas barrier
Electron micrograph of pulmonary capillary
High power view of blood-gas barrier
Fick’s law of diffusion through a tissue sheet
Kinetic theory of gases
Fick’s law of diffusion through a tissue sheet
Diffusion and perfusion limitations
0 10 20 30 40 50 60 70 80 90 1000
10
20
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50
60
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90
100
110
PARTIAL PRESSURE, mm Hg
CO-Hb DISSOCIATION CURVES
AT
UR
AT
ION
, % CO
O2
Diffusion and perfusion limitations
Very thin blood-gas barrier
Thickened blood-gas barrier
Time courses of Po2 in the capillary
Measurement of Diffusing Capacity
Single breath method for DCO
Electron micrograph of pulmonary capillary
Reduced Hb
O2 solution
Mixing Chamber
t
Spectro Photometer
HBO2 %
100
0 0.1 0.2
time (sec)
Measurement of the rapid reaction of O2 with Hb
The two components of DL
Is the transfer of CO2 ever limited by diffusion?
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