Lecture13 Immunity
-
Upload
mbbs-ims-msu -
Category
Education
-
view
2.124 -
download
1
description
Transcript of Lecture13 Immunity
![Page 1: Lecture13 Immunity](https://reader034.fdocuments.in/reader034/viewer/2022052504/54864cd7b4af9f6d018b4a04/html5/thumbnails/1.jpg)
Immunity Overview
![Page 2: Lecture13 Immunity](https://reader034.fdocuments.in/reader034/viewer/2022052504/54864cd7b4af9f6d018b4a04/html5/thumbnails/2.jpg)
Types Of Immunity
1. Innate Immunity2. Acquired Immunity
A. Naturally Acquired Active Immunity
B. Artificially Acquired Active Immunity
C. Naturally Acquired Passive Immunity
D. Artificially Acquired Passive Immunity
![Page 3: Lecture13 Immunity](https://reader034.fdocuments.in/reader034/viewer/2022052504/54864cd7b4af9f6d018b4a04/html5/thumbnails/3.jpg)
Overview of Immunity
![Page 4: Lecture13 Immunity](https://reader034.fdocuments.in/reader034/viewer/2022052504/54864cd7b4af9f6d018b4a04/html5/thumbnails/4.jpg)
Naturally Acquired Active Immunity
Naturally acquired active immunity is obtained when a person is exposed to antigens in the course of daily life, direct exposure.
The immune system then responds by producing antibodies and specialized lymphocytes. Usually, the immunity is for a long term.
Examples, include measles, pox.
![Page 5: Lecture13 Immunity](https://reader034.fdocuments.in/reader034/viewer/2022052504/54864cd7b4af9f6d018b4a04/html5/thumbnails/5.jpg)
Artificially Acquired Active Immunity
Artificially acquired active immunity results from
vaccination or immunizations. Vaccination introduces specially prepared
antigens into the body.These antigens are no longer able to cause
disease, but they are still able to stimulate an immune response.
![Page 6: Lecture13 Immunity](https://reader034.fdocuments.in/reader034/viewer/2022052504/54864cd7b4af9f6d018b4a04/html5/thumbnails/6.jpg)
Naturally Acquired Passive Immunity
Naturally acquired passive immunity involves the natural transfer of antibodies from a mother to a child. An expectant mother is able to pass some of her antibodies to her fetus across the placenta.
In addition, certain antibodies are also passed from the mother to the child during breast feeding. Generally immunity lasts only as long as the
antibodies are active usually a few weeks or 6 months.
![Page 7: Lecture13 Immunity](https://reader034.fdocuments.in/reader034/viewer/2022052504/54864cd7b4af9f6d018b4a04/html5/thumbnails/7.jpg)
Artificially Acquired Passive Immunity
Artificially acquired passive immunity involves an
injection of antibodies into the body.
These antibodies come from an animal or human who is already immune to the disease.
![Page 8: Lecture13 Immunity](https://reader034.fdocuments.in/reader034/viewer/2022052504/54864cd7b4af9f6d018b4a04/html5/thumbnails/8.jpg)
Immunity OverviewImmunity: The body's ability to fight off
harmful micro-organisms –PATHOGENS- that invade it.
The immune system produces antibodies or cells that can deactivate pathogens.
Fungi, protozoans, bacteria, and viruses are all potential pathogens.
Antigen: Molecules from a pathogen or foreign organism that provoke a specific immune response.
![Page 9: Lecture13 Immunity](https://reader034.fdocuments.in/reader034/viewer/2022052504/54864cd7b4af9f6d018b4a04/html5/thumbnails/9.jpg)
The Immune System - includes all parts of the body that help in the recognition and destruction of foreign materials. White blood cells, phagocytes and lymphocytes, bone marrow, lymph nodes, tonsils, thymus, and spleen are all part of the immune system.
![Page 10: Lecture13 Immunity](https://reader034.fdocuments.in/reader034/viewer/2022052504/54864cd7b4af9f6d018b4a04/html5/thumbnails/10.jpg)
Function of the immune systemDestroy pathogensDetect and kill abnormal cellsRemove dead cells and other
debris from the body
![Page 11: Lecture13 Immunity](https://reader034.fdocuments.in/reader034/viewer/2022052504/54864cd7b4af9f6d018b4a04/html5/thumbnails/11.jpg)
The Immune System is the Third Line of Defense Against Infection
![Page 12: Lecture13 Immunity](https://reader034.fdocuments.in/reader034/viewer/2022052504/54864cd7b4af9f6d018b4a04/html5/thumbnails/12.jpg)
Third-Line Defenses - Sometimes the second line of defense is still not enough and the pathogen is then heading for the body's last line of defense, the immune system.
The immune system recognizes, attacks, destroys, and remembers each pathogen that enters the body. It does this by making specialized cells and antibodies that render the pathogens harmless.
Unlike the first line and second line defense the immune system differentiates among pathogens.
For each type of pathogen, the immune system produces cells that are specific for that particular pathogen.
![Page 13: Lecture13 Immunity](https://reader034.fdocuments.in/reader034/viewer/2022052504/54864cd7b4af9f6d018b4a04/html5/thumbnails/13.jpg)
An antibody is a protein produced in response to an antigen.
Antigens are macromolecules that elicit an immune response in the body. The most common antigens are proteins and polysaccharides.
![Page 14: Lecture13 Immunity](https://reader034.fdocuments.in/reader034/viewer/2022052504/54864cd7b4af9f6d018b4a04/html5/thumbnails/14.jpg)
Antigens can enter the body from the environment. These include
inhaled macromolecules (e.g., proteins on cat hairs that can trigger an attack of asthma in susceptible people)
ingested macromolecules (e.g., shellfish proteins that trigger an allergic response in susceptible people)
molecules that are introduced beneath the skin (e.g., on a splinter or in an injected vaccine)
![Page 15: Lecture13 Immunity](https://reader034.fdocuments.in/reader034/viewer/2022052504/54864cd7b4af9f6d018b4a04/html5/thumbnails/15.jpg)
antigens can be generated within the cells of the body. These include
proteins encoded by the genes of viruses that have infected a cell
Proteins that are encoded by mutant genes; such as mutated genes in cancer cells
![Page 16: Lecture13 Immunity](https://reader034.fdocuments.in/reader034/viewer/2022052504/54864cd7b4af9f6d018b4a04/html5/thumbnails/16.jpg)
protect against specifically identified threats (i.e. may defend against one particular bacterial infection but not a different one)
many specific defenses develop after birth upon exposure to an antigen; an antigen can be a pathogen (disease-causing organism), foreign protein (e.g. toxin), abnormal or infected body cell, foreign tissue transplant
specific defenses produce a state of long-term protection known as “Immunity”
Specific defenses
![Page 17: Lecture13 Immunity](https://reader034.fdocuments.in/reader034/viewer/2022052504/54864cd7b4af9f6d018b4a04/html5/thumbnails/17.jpg)
ImmunityImmunity = specific resistance to disease
depends on coordinated activity of T & B lymphocytes
Humoral immunity involves the antibodies and the B cells that they secret them; is directed against extracellular pathogens
Cellular immunity involves T lymphocyte that directly attack other cells; defense against abnormal cells & intracellular pathogens
![Page 18: Lecture13 Immunity](https://reader034.fdocuments.in/reader034/viewer/2022052504/54864cd7b4af9f6d018b4a04/html5/thumbnails/18.jpg)
Humoral and cellular immunity
Humoral Immunity
Cellular Immunity
Type of cells B-Cells T-Cell
Antibody Involvement
Yes No
Location of pathogen
Extracellular Intracellular
![Page 19: Lecture13 Immunity](https://reader034.fdocuments.in/reader034/viewer/2022052504/54864cd7b4af9f6d018b4a04/html5/thumbnails/19.jpg)
Immunity is the result of the action of two types lymphocytes, the B lymphocytes and the T lymphocytes.
B cells produce antibodies that are secreted into the blood and lymph.
T cells attack the cells that have antigens that they
recognize.
![Page 20: Lecture13 Immunity](https://reader034.fdocuments.in/reader034/viewer/2022052504/54864cd7b4af9f6d018b4a04/html5/thumbnails/20.jpg)
Shared feature of B & T lymphocyteSpecificity of receptors: Both B & T
lymphocyte have specific receptor for specific antigen
Diversity of receptors: There are huge numbers of different lymphocyte each with its own unique antigen receptor
Regulation of activation: Activation of B & T cells leads to process clonal expansion
Memory: Respond to subsequent exposure to the same antigen
![Page 21: Lecture13 Immunity](https://reader034.fdocuments.in/reader034/viewer/2022052504/54864cd7b4af9f6d018b4a04/html5/thumbnails/21.jpg)
Antigen: Self AntigenThere are a vast number of
antigen outside the body. There are also internal antigen called self antigen.
Lymphocyte must recognize antigen from pathogen while ignoring self antigen
![Page 22: Lecture13 Immunity](https://reader034.fdocuments.in/reader034/viewer/2022052504/54864cd7b4af9f6d018b4a04/html5/thumbnails/22.jpg)
Antigen receptor- SpecificityThe surface of mature B & T lymphocyte
studded with lymphocyte antigen receptor that allows these cells to identify their particular antigen shape
The antigenic specificity of B & T lymphocyte is determined by the shape of their antigen receptor
B & T cells have a related structure and similar function, there are differences in their shape and the way they interact with antigen
![Page 23: Lecture13 Immunity](https://reader034.fdocuments.in/reader034/viewer/2022052504/54864cd7b4af9f6d018b4a04/html5/thumbnails/23.jpg)
Antigen receptorThe B cell antigen receptor is Y-
shape antibody molecule and directed against antigen in the extracellular fluid
When the antigen occupy the antigen binding site on the B cell receptors, the receptor signals the cell that antigen found
![Page 24: Lecture13 Immunity](https://reader034.fdocuments.in/reader034/viewer/2022052504/54864cd7b4af9f6d018b4a04/html5/thumbnails/24.jpg)
Antigen receptorT lymphocyte receptor is not:1. Membrane bound antibody2. Y-Shaped T cell directed against the
body’s own cells when they are invaded
![Page 25: Lecture13 Immunity](https://reader034.fdocuments.in/reader034/viewer/2022052504/54864cd7b4af9f6d018b4a04/html5/thumbnails/25.jpg)
Antigen receptorWhen antigen bind receptors and
activate the receptors, the cell divides and make clone with identical receptor
This matching mechanism called clonal selection
![Page 26: Lecture13 Immunity](https://reader034.fdocuments.in/reader034/viewer/2022052504/54864cd7b4af9f6d018b4a04/html5/thumbnails/26.jpg)
Humoral (Antibody-Mediated) Immunity◦ Involves production of antibodies against
foreign antigens.◦ Antibodies are produced by a subset of
lymphocytes called B cells.◦ B cells that are stimulated will actively secrete
antibodies and are called plasma cells.◦ Antibodies are found in extracellular fluids
(blood plasma, lymph, mucus, etc.) and the surface of B cells.
◦ Defense against bacteria, bacterial toxins, and viruses that circulate freely in body fluids, before they enter cells.
◦ Also cause certain reactions against transplanted tissue.