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Laser Vibro Cardio GraphNon contact, distance, high resolution displacement measurement for Cardiac, Vascular and Respiratory measurement related to vessel compliance, pulse velocity and vessel impedence changes, heart beat and respiration rithm

Application examples:• Burnt patient monitoring (no electrodes on skin)• Ventricular Synchronization without Echographic

guide; Sudden dead in Children Monitoring• MRI cardiac monitoring, Survey in pharmacy • Vascular disease and Cardiac surgery weaning

Future development: economic device from industrial engineering to put the technology on the health marketCollaboration : Crisel InstrumentOspedale Bambino Gesù - Rome

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International Patent by researchers of ISS - Università Politecnica delle Marche – Politecnico di Torino

Simpato-vagal balance (ARMA spectra and fractal dimensions identification

VCG

ECG

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Cardiovascular bioengineering unit:

Pathologies:Heart failureAtrial fibrillationBradiarrhytmias, tachiarrhythmias

Research areas:

• Biomedical signal processing of ECG, intracardiac signal, body surface potential map, heart rate variability, gene expression data

• Telemedicine solutions: design, realization, prototyping and assessment

• Electromagnetic interference on medical devices: wireless communication technology and/or MRI versus active implantable devices (pacemakers, neurostimulators, etc…) and life-support devices

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Anechoic chamber (with associated instrumentations) MRI RF coil (with associated instrumentations) Luxtron Fluoroptic temperature probes

Cardiovascular bioengineering unit:

Biomedical signal acquisition and processing:

Biosemi (multichannel biopotential acquisition system, for research use only)

Biopack (MRI compliant acquisition system, for research use only) Portapress (non-invasive continous blood pressure

monitoring) Matlab SW Labview SW

Laboratory facilities and instrumentation

Electronic workshop:

Printed circuits design and realization Microcontroller IDE SW Altium SW

Electromagnetic compatibility laboratory:

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CollaborationCollaboration::Prof. Yosi ShachamProf. Yosi Shacham

Faculty of EngineeringFaculty of EngineeringTel AvivTel Aviv

IMM-CNR

ISS

Design and fabrication of large-area, ultra-flexible, active grids for recording and stimulation on the cortical surface.

Moderately invasive, chronically implantable device for improving rehabilitation through stimulation

Planned design

Prototype: Kapton thin grid; piezo motors for concurrent depth electrodes penetration

PI film with polysilicon TFTs

Innovative devices for Neuro-rehabilitation

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CollaborationCollaboration: Prof. Shimon Marom Technion, Haifa: Prof. Shimon Marom Technion, Haifa

Cortical neurons cultured on microarrays and superposed spikes from a single neuron.

Patterned substrate for growing modular networks of cortical neurons in-vitro

Theory: inferring the stimulated remote site from the spectral analysis of local activity

ISS

Marom Marom

Needed: understanding the effect of direct stimulation in complex networks of neurons

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Molecular imaging with radionuclides

• Optimize exploitation of the electronics features

Future development:• Improve coregistration of the heads images

Compact, dual head, scintimammograph• Early detection of breast cancer• Optimized for breast compression and

dual modal• International patent pending

Open, multi-heads SPECT system

Application examples:• Therapeutic effectiveness of stem cell

in stroke induced heart disease• Atherosclerotic plaques identification

Dedicated electronics with independent channel readout and smart real time processing

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Applications:

• Support radiological emergency

• Radiological surveillance on large scale

• Mapping of radioactive contamination on ground

• Atmospheric pollution monitoring

SNIFFER: Aerial platform for nuclear emergency and environmental monitoring

ISTISAN report: 07/33Web: http://www.iss.infn.it/webg3/g3iss/aereo/

SNIFFER Components• Compact aerial platform• Isokinetic sampling system for quantitative particulate radioactivity measurements

• Nuclear detectors for radioactivity contamination measurements on ground and in atmosphere, with gamma-radioisotopes identification

• VOC-PAH sampling unit for measurements of organic pollutants

• Management, control and acquisition system, including environmental sensors and geolocation devices

• Migrate on an unmanned aerial platform

• Improve nuclear detectors

Future development:• Real-time air-ground data communication

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The Department is active, from many years, in this research field. Retina is the focal point, due to the growing incidence and social impact of macular degenerations on a aging population.

VISION and OPHTHALMOLOGY

Innovative methods are developed in our labs and applied in physiological and clinical studies, to improve knowledge of retinal function and assess new therapeutic approaches.

Our focal ERG system is equipped with a special electronics, needed to evaluate extremely low-level responses, as occurs in clinical trials involving patients with advanced AMD

An experimental LDF apparatus (Laser Doppler Flowmetry) is under development. Includes multispectral light stimulation to study retinal neurovascular coupling

In collaboration with:- Benedetto Falsini, Catholic University, Rome- Eyal Banin, Hadassah Hospital, Jerusalem- Charles Riva, Institute of Research in Ophthalmology, Sion- Vittorio Porciatti, Bascom Palmer Eye Institute, Miami

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