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Lab 9: Endocrine System. Review Where does pepsinogen come from? Why doesn’t the stomach digest...
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Transcript of Lab 9: Endocrine System. Review Where does pepsinogen come from? Why doesn’t the stomach digest...
Review
• Where does pepsinogen come from?
• Why doesn’t the stomach digest itself?
• Why can Veggans not eat meat anymore?
Function
• Maintain Homeostasis (Balance)– Communicates and coordinates physiological
responses
• Example of Imbalance?
Hormones
• Chemical messengers– Stimulate physiological responses in other cells– Target Cells
• Tropic (Trophic) Hormones– Hormone whose target is another endocrine
gland.
• How do hormones travel?
Hormone Production and Distribution
• Production– Endocrine Glands– Gland: an organ specialized to produce
secretions
• Distribution– Relies on blood circulatory system
• How does this compare to nervous system?
Hypothalamus• Location- Base of brain
case• Functions- Regulation
of Primitive or Basal activities such as sex drive and water balance
• 9 hormones-– 7 act on anterior lobe of
pituitary gland (Tropic)– 2 stored in posterior
lobe
Hypothalamo-hypophyseal portal system
• What type of vessels comprise a portal system?
• What is unique about a portal system?
Hypothalamo-hypophyseal portal system and tract
• Location-– Pituitary Stalk
(Infundibulum)• Link the hypothalmus
to the pituitary gland• Portal- Capillary beds
connect to anterior lobe
• Tract- Neurons connect to posterior lobe
Pituitary gland• Location- Sphenoid
bone of the skull• Anterior Lobe
– Produces Six hormones that Regulate
• Reproduction• Growth• Activity of the
Thyroid Gland
• Posterior Lobe– No hormone production
only storage of hypothalamic hormones
Thyroid
• Largest endocrine gland
• Location- Wrapped around anterior and lateral sides of Trachea, just below Larynx
• Hormone- Thyroid Hormone• Function- Increases Metabolic
Rate
Parathroid Glands
• Location- Four glands imbedded on posterior surface of Thyroid
• Hormone- Parathyroid Hormone
• Function- Calcium Regulation
Adrenal Glands
• Cortex– Zona Glomerulosa:
Outer layer– Zona Fasciculata:
Middle Layer– Zona Reticularis-
Inner Layer
• Medulla
• Location- 2 glands one
superior to each Kidney.
Adrenal Glands
• Cortex- – Zona Glomerulosa
• Mineralocorticoids- Regulate Kidney Na+ and K+ excretion
– Zona Fasiculata • Glucocorticoids- Stress
and immune supression
– Zona Reticulata-• Sex steroids- androgens
precursor to sex hormones
• Medulla- (Fight or Flight Response) Epinepherine and Norepinephrine
Pancreas• Location- Inferior
and posterior to Stomach
• Pancreatic Islets– Clusters of
endocrine cells
• Function- Glucose Regulation
Gonads
• Male- Testes– Secrete Androgens such as Testosterone
• Female- Ovary– Secrete Estrogen and Progesterone
Homeostatic Control
• Metabolic Rate
• Growth Hormone
• Blood Glucose Levels
• Blood Calcium Levels
• Water Retention
• Stress
Metabolic RateGland Hormones
Hypothalamus Thyrotropin Releasing Hormone (TRH)
Pituitary Gland Thyroid Stimulatory Hormone (TSH)
Thyroid Thyroxine (T4) and Triiodothyronine (T3)
Metabolic Rate
• Hormones released in response to a decrease in T3 blood levels
• Affects: All cells in the body except brain, spleen, testes, uterus and the thyroid gland
• Results: Increase in basal metabolic rate, oxygen consumption and heat production
Disorders
• Hypothyroidism (Creatinism)– Children: mental
retardation, development abnormalities
– Adults: lethargy, obesity
• Goiter
• Hyperthyroidism (Graves’ Disease)– Weight loss, sweating,
nervousness, sleeplessness
• Goiter -----a hypertrophy of the
thyroid gland resulting from iodine deficiency
Growth• Gland- Pituitary Gland• Hormone-
– Growth Hormone: increases mitosis and cellular differentiation.
– Secreted in response to Sleep, Trauma, Exercise, High protein meals, and Low blood sugar
• Effects– Directly: Liver – Indirectly: Bone, Muscle, and Cartilage
Disorders• Pituitary Dwarfism-
Insufficient secretion of Growth Hormone
• Gigantism- Over-secretion of Growth Hormone
Blood Glucose Levels• Gland- Pancreas• Hormones
– Insulin- increases uptake of glucose by cells– Glucagon- increases release of glucose by cells
and increases liver glucose production• Released in response to…
– Insulin: high blood glucose levels– Glucagon: low blood glucose levels
• Effects-– Systemic– Liver
Disorders• Diabetes Mellitus- Disruption of Metabolism due
to lack of insulin or lack of response to insulin.
• Symptoms- Excessive Urine, Intense Thirst, and Ravenous Hunger
• Type I- (Juvenile of Insulin Dependant) Destruction of Insulin Producing Cells
• Type II- (Adult or Noninsulin Dependant) Target cells resistant to Insulin
Blood Calcium Levels
• Gland- Parathyroid
• Hormone- Parathyroid hormone– Released in response to low calcium levels
• Effects – Kidneys- Retain Calcium– Bones- Release Calcium
Disorders
• Hyper- or Hypo-parathyroidism– Hyper-parathyroidism: Over Secretion
• Soft, Fragile Bones • Kidney stones
– Hypo-parathyroidism: Under Secretion• Rapid Decline of Blood Calcium
• Fatal
Water Retention
• Gland- Hypothalamus– Stored and released by posterior pituitary
• Hormone- ADH– Released in response to Dehydration and High
Osmolarity (thickening) of blood
• Effects?
Disorders
• Cushing Syndrome– Cause: Excess
Glucocorticoids– Disrupts Protein and Fat
Metabolism– Symptom is abnormal fat
deposits, fatigue and exhaustion