Kuan-Liang Kuo, MD 1, 2 ( Email: [email protected] ) Hsi-Chang Lee, MMS 3
4
The Bioinformatics System for the Research of Interleukin 1 Gene Polymorphisms and Related Factors in Gastric Cancers Kuan-Liang Kuo, MD 1, 2 (Email: [email protected]) Hsi-Chang Lee, MMS 3 Chiou-Shann Fuh, PhD 2 1 Family Medicine Department, Ren-Ai Branch, Taipei City Hospital, Taipei, Taiwan 2 Department of Computer Science and Information Engineering, National Taiwan University, Taipei, Taiwan 3 Gastroenterology Department, Ren-Ai Branch, Taipei City Hospital, Taipei, Taiwan 2008 American Medical Informatics Association Spring Congress
description
The Bioinformatics System for the Research of Interleukin 1 Gene Polymorphisms and Related Factors in Gastric Cancers. Kuan-Liang Kuo, MD 1, 2 ( Email: [email protected] ) Hsi-Chang Lee, MMS 3 Chiou-Shann Fuh, PhD 2 - PowerPoint PPT Presentation
Transcript of Kuan-Liang Kuo, MD 1, 2 ( Email: [email protected] ) Hsi-Chang Lee, MMS 3
The Bioinformatics System for the Research of
Interleukin 1 Gene Polymorphisms and Related Factors in
Gastric Cancers
Kuan-Liang Kuo, MD1, 2 (Email: [email protected])
Hsi-Chang Lee, MMS3 Chiou-Shann Fuh, PhD2
1Family Medicine Department, Ren-Ai Branch, Taipei City Hospital, Taipei, Taiwan
2Department of Computer Science and Information Engineering, National Taiwan University, Taipei, Taiwan
3Gastroenterology Department, Ren-Ai Branch, Taipei City Hospital, Taipei, Taiwan
2008 American Medical Informatics Association Spring Congress
Multiple factors, include Interleukin-1 gene polymorphisms, Helicobacter pylori infection, and endocrines, are thought to be related to gastric disorders.
As the diversity of etiologies, the research in this domain is multidisciplinary. We propose the bioinformatics system to assist the researchers to cooperate in the storing and analyzing of multitudinous genetic and clinical data.
2008 American Medical Informatics Association Spring Congress
Introduction
System Framework
Web Server
Database
Database ToolsIntelligent Components
Clustering
Rule Base
Maintenance
Query
FIS
Clinical Components
CDSS
Alert System
FIS: Fuzzy Inference SystemCDSS: Clinical Decision Support System
2008 American Medical Informatics Association Spring Congress
Clinical Research Model of Gastric Cancer
Intestinal type: chronic gastritis -> chronic atrophic gastritis -> intestinal metaplasia -> dysplasia -> cancer
Diffuse type: chronic gastritis -> cancer
Inflammation is the key to the development of gastric cancer.
Interleukin (IL) 1 β plays an important role in initiating and amplifying the inflammatory response to H. pylori infection.
Materials and Methods
Histological finding from biopsy specimens
Helicobacter pylori
Updated Sydney System (diagnosis)
Expression of IL-1β Receptor (immunoreactive score)
DNA from Peripheral Blood Samples
IL-1 Polymorphisms (IL-1B-31, IL-1B-511, IL-1RN)
Result of Clinical Research
Gender and age differences exist in gastric inflammation after H. pylori infection.
Summary of Conclusion
2008 American Medical Informatics Association Spring Congress
Male FemaleAge < 50 Age > 500.0
0.2
0.4
0.6
0.8
1.0
System and information qualities are confirmed by system accuracy, flexibility, reliability, and informativeness. Use and user satisfaction are evaluated by number of use, number of records, software satisfaction, and decision-making satisfaction. The results revealed mostly positive response.
Further Perspective:
Whether IL-1 receptor expression is different between female and male
Correlate IL-1 receptor expression and gastric inflammation
Whether different IL-1 receptor expressions are related to gene or to gender only.
In vitro studies of estrogen effect on gastric epithelial cells.
H. pylori (+) Number of patients
Mean of inflammation score (antrum)
Male, Age<50 300 0.49
Female, Age<50 314 0.37
Male, Age 50≧ 252 0.93
Female, Age 50≧ 229 0.91
